Microtomy inspection system with universal base

Abstract

The system includes a base, a first attachment component, and a second attachment component. The base includes a receiving body and a control unit. The receiving body includes a receiver and a heating element proximate to the receiver. The control unit includes one or more user interface features configured to control the heating element. The first attachment component is configured to process one or more tissue samples after sectioning using a microtome and is further configured to be received by the receiver. The second attachment component is configured to be received within the receiver. The first attachment component is configured for different processing functions of the one or more tissue samples after sectioning using a microtome relative to the second attachment component. The first attachment component and the second attachment component are configured to be interchangeably received within the receiver.

Description

[Background technology]

[0001] A microtome is a device configured to provide sections of material in a controlled manner. Such sections, once produced by a microtome, may be transilluminated for analytical purposes as part of the histological process. Specifically, analysis of such sections may be used in pathology laboratories for analysis of tissue samples. In some circumstances, the thickness of such sections may be between about 0.1 and 100 μm. The use of a microtome may be referred to as "microtomy" in some circumstances.

[0002] In microtomy methods, particularly for the analysis of tissue samples, one or more tissue samples may first be embedded in paraffin wax and then sectioned using a microtome. Such an embedding process may be used to provide structural stability to the tissue sample for subsequent manipulation during sectioning. Embedding may include various accessories such as wax baths, cryogenic plates, etc. A microtome may then be used to section the embedded tissue sample, producing multiple prepared sections, each section containing a combination of tissue and paraffin wax in a single thin film.

[0003] In some circumstances, a microtome may be used with certain accessory devices to aid in the processing of the prepared sections. For example, one example of processing may include transferring each of the prepared sections onto a specimen slide. Several methods may be used for such transfer, one example being the use of a water bath. In such uses, the prepared sections may be suspended on the surface of the water bath, thereby spreading the prepared sections out into a flat arrangement. A technician may then manipulate the specimen slide beneath the prepared sections to "scoop" or otherwise transfer the prepared specimens from the water bath onto the specimen slide. Examples of some such water baths are described in U.S. Patent No. 8,642,930, entitled "Device for Heating an Object by Means of Water Bath," filed February 4, 2014.

[0004] After the prepared sections are transferred to the specimen slide, it may be desirable to dry the specimen slide containing the prepared sections. For example, in the water bath transfer example described above, at least some water may remain, either on the specimen slide itself or between the prepared section and the specimen slide. The presence of such water may lead to artifacts or unwanted shifts in imaging of the prepared sections. Thus, in some situations, it may be desirable to dry the specimen slide containing the prepared sections. In some examples, drying may be facilitated by a heated slide rack or oven.

[0005] While several medical devices, systems, and methods have been made and used, it is believed that no one prior to the inventors made or used the invention as set forth in the appended claims.

[0006] Aspects of the present disclosure are hereinafter described in connection with the accompanying drawings, which are provided to illustrate aspects of the present disclosure and not to limit it, and in which like designations refer to like elements. [Brief description of the drawings]

[0007] [Figure 1] FIG. 1 shows a perspective view of an example of a base for use in microtomy with certain accessory components. [Diagram 2] FIG. 2 shows an exploded perspective view of the base of FIG. 1 used in an example of a slide dryer. [Diagram 3] 3 shows a perspective view of the base of FIG. 1 with the slide dryer of FIG. 2 inserted into the base. [Figure 4] 2 shows a schematic side view of the floor of the base of FIG. 1; [Diagram 5] FIG. 2 shows a side view of an example of another slide dryer for use with the base of FIG. 1. [Figure 6] 2 shows a side view of another example of a slide dryer for use with the base of FIG. 1. [Figure 7] 2 shows an exploded perspective view of the base of FIG. 1 used in an example water bath; [Figure 8] 8 shows a perspective view of the base of FIG. 1 with the water bath of FIG. 7 inserted into the base. [Figure 9] FIG. 2 shows an exploded perspective view of the base of FIG. 1 used in an example slide oven. [Figure 10] 1 with the slide oven of FIG. 9 inserted into the base. [Figure 11] 2 illustrates a schematic top view of an exemplary arrangement of multiple bases of FIG. 1 used to support the use of multiple accessory components. [Figure 12] 2 illustrates a schematic top view of another exemplary arrangement of multiple bases of FIG. 1 used to support the use of multiple accessory components. [Figure 13] 10 illustrates a schematic top view of yet another exemplary arrangement of multiple bases of FIG. 1 used to support the use of multiple accessory components. [Figure 14] FIG. 2 shows a side view of multiple bases of FIG. 1 being used together; [Figure 15] FIG. [Figure 16] 16 shows a bottom view of the water bath base of FIG. 15. [Figure 17] FIG. 16 shows a perspective view of a cable for use with the water bath base of FIG. [Figure 18] FIG. 2 is a top perspective view of the slide dryer base. [Figure 19] FIG. 19 shows a bottom view of the slide dryer base of FIG. 18. [Figure 20] 15 is a bottom view of the water bath base of FIG. 15 used with the slide dryer base of FIG. 18. [Figure 21] 19 shows a schematic top view of an exemplary arrangement of the water bath base of FIG. 15 with the slide dryer base of FIG. 18. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0008] I. Overview of an Exemplary Universal Attachment Base Aspects of the present disclosure may be integrated into specimen preparation and analysis systems capable of performing a variety of biological sample preparation and analysis procedures (e.g., histology). Although aspects of the present disclosure are described herein in the context of microtomy, it should be understood that in some circumstances such aspects may be used in other contexts. For example, other suitable contexts may include tissue sectioning, embedding, staining, etc.

[0009] Various examples are described below in conjunction with the drawings for illustrative purposes. It should be understood that many other implementations of the concepts of the present disclosure are possible, and various advantages can be achieved by the implementations of the present disclosure. Headings are included herein for reference and to aid in identifying the various sections. These headings are not intended to limit the scope of the concepts described with respect thereto. Concepts such as these are applicable throughout the entire specification.

[0010] 1 shows an example of a base 10 configured for use with certain accessories used during microtomy. As described in more detail below, this version of the base 10 is configured to receive various modular components to customize the base 10 for a given function. For example, the base 10 may receive a slide rack module for a slide drying function, a water bath module for a function of transferring prepared sections to specimen slides, and / or an oven module for a slide drying function. Although the base 10 is described herein as being usable with certain specific modules, it should be understood that in other versions the base 10 may be used with other modules adapted for other functions.

[0011] The base (10) is further configured for modular use in connection with another base similar to the base (10). Specifically, in some situations, it may be desirable to use multiple accessories within a limited area or space, such as the space near a microtome. However, the presence of multiple accessories may unnecessarily consume such space due to separate power connections or irregular accessory shapes and / or sizes. Thus, the base (10) is generally configured to communicate with other bases (10) similar to the base (10) to reduce the power connections and the overall footprint of the combination of the base (10) and the other bases (10).

[0012] The base (10) includes a receiving body (20) and a support platform (40) positioned below the receiving body (20). The receiving body (20) includes a receiver (22) and a control (32) adjacent the receiver (22). The receiver (22) extends downwardly within a portion of the receiving body (20) and is configured as a square or rectangular shaped recess that defines a floor (24). As described in more detail below, the floor (24) may be inclined or angled relative to a horizontal axis of the base (10) to aid in fluid management.

[0013] The receiver 22 further includes a heating element 26, a pressure switch 28 (also referred to as an accessory sensor), and a temperature sensor 30. Each of the heating element 26, the pressure switch 28, and the temperature sensor 30 may be positioned below the floor 24, above the floor 24, on top of the floor 24, or integral with a portion of the floor 24. Additionally, as described in more detail below, each of the heating element 26, the pressure switch 28, and the temperature sensor 30 may be in communication with a portion of the control unit 32 to facilitate operation of the base 10.

[0014] The heating element (26) is generally configured to heat a space defined by the receiver (22). As described in more detail below, the receiver (22) may be used to receive various modular ancillary components that may use heat. Thus, the heating element (26) may be used to provide thermal communication from the receiver (22) to the various ancillary components. Thus, in some versions, the heating element (26) itself and / or portions of the floor (24) may include a thermally conductive medium to facilitate the transfer of heat to other components.

[0015] Heating element (26) may include various heat sources or combinations of heat sources. By way of example only, in some versions, heating element (26) may include one or more heat pads, one or more electrical resistance heating elements, etc. In the present version, heating element (26) corresponds to approximately the same area defined by floor (24) such that heat may be radiated upwardly from floor (24) into receiver (22). In some versions, at least a portion of heating element (26) may be incorporated into other portions of receiver (22), such as sidewalls, to radiate heat horizontally or from other directions.

[0016] The pressure switch (28) is generally configured to detect the presence of the accessory component when the accessory component is seated or otherwise disposed within the receiver (22). In this version, the pressure switch (28) communicates with the control unit (32) to turn off or interrupt the circuit of the heating element (26) when a particular condition is encountered. For example, in some versions, the pressure switch (28) itself, or a control circuit associated with the pressure switch (28), may be calibrated to turn off the heating element (26) when it detects limited or no pressure on the bed (24). In other words, the pressure switch (28) may be calibrated to detect the mass of the accessory component when the accessory component is seated or otherwise disposed within the receiver (22) to enable operation of the heating element (26). In the absence of an accessory component, pressure switch (28) may be in an open state, thereby breaking the circuit with heating element (26) and turning off heating element (26) when an accessory component is not seated or otherwise disposed within receiver (22).

[0017] It should be appreciated that pressure switch (28) may include a variety of components having the above functionality. For example, in some versions, pressure switch (28) may include a resilient biasing mechanism in communication with bed (24) to detect a predetermined force applied to bed (24). Such a resilient biasing mechanism may include, for example, a spring-loaded plunger that may be coupled to bed (24) or may protrude from a portion of bed (24). The spring-loaded plunger may then be actuated by the mass of an attached component, either through bed (24) or directly engaging the spring-loaded plunger. In other versions, the spring-loaded plunger may be recessed beneath bed (24) and the attached component may include a protrusion or other member configured to engage the spring-loaded plunger. In other versions, pressure switch (28) may include a variety of other sensors, such as Hall effect sensors, proximity sensors, optical sensors, and the like. Of course, in other versions, pressure switch (28) may have a variety of alternative configurations, as will be apparent to those of ordinary skill in the art in light of the teachings herein.

[0018] The temperature sensor (30) is generally configured to detect a temperature proximate the floor (24). While in this version the temperature sensor (30) is shown as a single point, it should be understood that the temperature sensor (30) may include multiple temperature sensors (30) linked in an array. The temperature sensor (30) may be in communication with a controller (32) to detect and communicate to an operator a temperature associated with the receiver (22) in real time. As described in more detail below, such real-time temperature measurements may be associated with modular accessory components received within the receiver (22).

[0019] The controller 32 includes a display 34, input features 36, and indicators 38. The controller 32 of this example further includes a processor 33 and / or other control circuitry to support the use of the display 34, input features 36, and indicators 38, which are in communication with the heating element 26, pressure switch 28, and temperature sensor 30. For example, the input features 36, pressure switch 28, and temperature sensor 30 may be in communication with the processor 33, such that the processor 33 may receive operational inputs from the input features 36, pressure switch 28, and temperature sensor 30 described above. The processor (33) may also be in communication with the heating element (26), the display (34), and the indicators (38) to drive the heating element (26), the display (34), and the indicators (38) based on inputs received from the input features (36), the pressure switch (28), and the temperature sensor (30). The processor (33) may be used, in some versions, to provide a closed loop feedback control algorithm for maintaining the receiver (22) within a selected temperature range. Similarly, the pressure switch (28) may be in communication with the control circuitry to interrupt or modify such control algorithms. Similarly, the display (34), the input features (36), and the indicators (38) may be in communication with the control circuitry to provide operator control or operator feedback.

[0020] Display (34) is generally configured to provide feedback to an operator. In the present version, display (34) includes an LED display, an OLED display, etc. In any case, display (34) may be configured to present operational information to the operator, such as the temperature detected by temperature sensor (30), menu options or other graphical user interface, timers, etc.

[0021] Input feature 36 is configured to allow for user input. In this version, input feature 36 includes two triangular buttons that may be used to adjust the temperature generated by heating element 26 up or down. Additionally or alternatively, buttons such as these may be used to cycle through different predetermined modes, which may be shown on display 34 as the operator cycles through them.

[0022] Indicator (38) is configured to provide certain operational status information to the operator. For example, in this version, indicator (38) includes a single-color or multi-color LED that may illuminate differently to communicate operational status to the operator. In some versions, indicator (38) may indicate that a certain temperature (e.g., an operator-set value) has been reached by displaying one of a number of colors. Additionally or alternatively, in some versions, indicator (38) may indicate that a certain temperature has been reached by flashing or blinking at a particular frequency. Additionally or alternatively, in some versions, indicator (38) may also indicate other operational statuses, such as that heating element (26) is active but has not yet reached a predetermined temperature (e.g., preheating).

[0023] As described above, the support platform (40) is disposed below the receiving body (20). The support platform (40) is generally configured to support and elevate the receiving body (20) to a predetermined height. Additionally, the support platform (40) is recessed or recessed inwardly relative to the receiving body (20) to define a recess (46) (also referred to as a groove, channel, passageway, or compartment) below a portion of the receiving body (20). As described in more detail below, the recess (46) is generally configured to receive and store or accommodate a power cable (350), multiple power cables (350), or other features associated with the operation of the base (10).

[0024] In this version, the recess (46) extends around all sides of the support platform (40). In other words, each dimension of the support platform (40) is smaller than the corresponding dimension of the receiving body (20), such that the receiving body (20) defines an overhang, and the overhang defines a portion of the recess (46). It should be understood that while the recess (46) extends around all sides of the support platform (40) in this version, in other versions the recess (46) may extend around only one side, two sides, or three sides of the support platform (40).

[0025] As noted above, the recess (46) is configured to receive one or more power cables (350). It should therefore be understood that in some versions, the recess (46) may include one or more cable management features (48) to facilitate storage of such cables (350) within the recess (46). For example, in some versions, such cable management features (48) may include one or more magnets that may be configured to attract a metallic or magnetic collar or other feature associated with each power cable (350). In such versions, the one or more magnets may draw or attach a portion of each power cable (350) to a particular portion of the recess (46). In other versions, such cable management features (48) may include mechanical cable management features, such as mechanical fasteners. Fasteners such as these may be used to secure or couple each power cable (350) to a particular portion of the recess (46).

[0026] The support platform 40 further includes a power interface including a power output 42 and a power input 44. As described in more detail below, the power output 42 and the power input 44 are each generally configured to receive a power cable 350 to transfer power to and from the base 10. By way of example only, the power output 42 and the power input 44 may be configured to facilitate coupling of each base 10 to another base 10 similar to the base 10. As described in more detail below, this configuration may be desirable to couple or tether several bases 10 similar to the base 10 together to power all of such bases 10 using only a single power source.

[0027] While this version is shown as having separate and individual power output (42) and power input (44), it should be understood that in other versions, the power output (42) and power input (44) may be combined into a single port configured to transmit power either to or from the base (10). Additionally or alternatively, in some versions, the power output (42) and / or power input (44) may be duplicated. For example, in some versions, the support platform (40) may include power output (42) and / or power input (44) on all or some of the sides (e.g., right and left sides, front and rear, etc.) of the support platform (40). Additionally or alternatively, in some versions, the power output (42) and / or power input (44) may be duplicated on a single side of the support platform (40). For example, in some versions, one or more sides of the support platform 40 may include a single power input 44, but may include multiple power outputs 42 to support coupling of the base 10 to multiple other bases similar to the base 10. Of course, other suitable configurations of power outputs 42 and power inputs 44 will be apparent to those of ordinary skill in the art in view of the teachings herein.

[0028] II. Examples of Base Attached Components In conventional accessory devices for microtomy, such devices may be dedicated to a given purpose. For example, conventional accessory devices may include a dedicated slide dryer, a dedicated slide oven, or a dedicated water bath. However, such dedicated accessories may be inflexible under some circumstances, since the functionality of each device may be limited to the specific functionality of a given accessory device. Thus, as noted above, in some versions, it may be desirable to use the base (10) with a variety of different types of accessory components to facilitate flexibility. In such versions, the base (10) may function as a universal component configured to receive different accessory components as needed. In other words, the laboratory workspace may be more easily reconfigured by exchanging accessory components in a given base (10) without the need to move the base (10) itself. Some examples of accessory components that may be used interchangeably with the base (10) are described in more detail below.

[0029] A. Examples of components attached to slide dryers As best shown in Figures 2 and 3, the base (10) may, in some circumstances, be used with a slide dryer (110) (also referred to as a slide rack, slide holder, or slide heater). The slide dryer (110) is generally configured to be received within the receiver (22) of the base (10) and receive heat from the heating element (26) to dry specimen slides held on a surface of the slide dryer (110). The slide dryer (110) includes a support body (112) (also referred to as a body, support, or base) and a slide support (120) (also referred to as a shelf, slide shelf, or holder). The support body (112) and slide support (120) are configured together to hold one or more specimen slides proximate the heating element (26) and heat the held specimen slides to a desired temperature for purposes of drying.

[0030] The support body (112) extends downward from the slide support (120) and is configured to elevate the slide support (120) within the receiver (22) to be approximately flush with the top surface of the base (10). The support body (112) is generally configured as two or more legs extending vertically from each side of the slide support (120). In other versions, the support body (112) may include additional structural features, such as cross members, to provide additional structural rigidity to the slide dryer (110). Although not shown, it should be understood that in some versions, the support body (112) may further include a thermally conductive medium to facilitate the transfer of heat from the heating element (26) to the slide support (120). Additionally, in some versions, the support body (112) may further include features, such as a protrusion configured to engage the pressure switch (28) of the base (10) when the slide dryer (110) is fully seated within the receiver (22) as described above.

[0031] The slide support (120) is generally configured to provide a surface on which specimen slides need to rest for drying purposes. In this version, the slide support (120) is configured to hold a plurality of specimen slides at an angle relative to the horizontal axis of the slide dryer (110). In particular, the slide support (120) includes a plurality of angled slats (122) (also referred to as angled surfaces) configured to receive one or more specimen slides. Each angled slat (122) is connected to another angled slat (122) by a slide rest (124). In particular, each slide rest (124) projects vertically or at an angle from one angled slat (122) to another angled slat. Additionally, each angled slat (122) is oriented at an oblique angle relative to the horizontal axis of the slide dryer (110) such that a specimen slide may be received at an angle onto the surface of each angled slat (122). Each slide rest (124) is thus configured to hold the specimen slide in place to prevent the specimen slide from sliding.

[0032] As mentioned above, the floor (24) of the base (10) may be oriented at an angle relative to the horizontal axis of the base (10). As best shown in FIGS. 3 and 4, this orientation of the floor (24) may be configured to position the slide dryer (110) at the same angle when received within the receiver (22) of the base (10). Thus, in addition to the above-mentioned angle relative to the angled slats (122), the slide dryer (110) itself may be positioned at an angle. Such a configuration may be desirable in some versions to encourage fluid to flow away from the angled slats (122) and away from any specimen slides placed on the slide dryer (110), further facilitating drying of the specimen slides. Although not shown, it should be understood that in some versions, the floor (24) may include a drain and / or fluid receptacle proximate the bottom of the slope of the floor (24) to facilitate management of fluid communication from the slide dryer (110).

[0033] While in this version, each angled slat (122) is shown as oriented at a specific angle, it should be understood that in other versions, various alternative angles may be used. For example, as best shown in Figures 5 and 6, in some versions, two substantially similar slide dryers (160, 180) may be used interchangeably with the base (10). In versions such as these, one slide dryer (160) may include angled slats (172) oriented at a relatively shallow angle (see Figure 5), and another slide dryer (180) may include angled slats (192) oriented at a relatively steep angle (see Figure 6). Additionally or alternatively, in some versions, a single slide dryer (110) may include angled slats (122), with one or more of the angled slats (122) oriented at a different angle relative to another angled slat (122). Regardless of the particular configuration, the angle of each angled slat (122) is generally configured to facilitate drainage of fluid from the specimen slides during the slide drying process. In particular, the angle of each angled slat (122) may be configured to induce drainage of fluid from one or more specimen slides by gravity to facilitate drying, and heat from the heating element (26) may facilitate evaporation of the fluid to further facilitate drying.

[0034] B. Examples of water bath accessories As best shown in Figures 7 and 8, the base (10) may, in some circumstances, be used with a water bath (210) (also referred to as a floating bath, tissue bath, or liquid bath). The water bath (210) is generally configured to be received within the receiver (22) of the base (10), receive heat from the heating element (26), and hold water within a portion of the water bath (210). As noted above, the water bath (210) may be used in conjunction with a microtome to float prepared sections, thereby aiding in the transfer of the prepared sections to specimen slides. This version of the water bath (210) includes a support body (212) that defines a water tank (220) (also referred to as a fluid tank or fluid reservoir).

[0035] The support body (212) includes a floor (214) and a number of sidewalls (216) extending upwardly from the floor (214). The size and shape of the support body (212) generally corresponds to the shape of the receiver (22) of the base (10). Thus, the floor (214) in this version is configured to abut the floor (24) of the receiver (22) when the water bath (210) is received in the base (10). Although not shown, it should be understood that in some versions, the support body (212) may include a thermally conductive medium to facilitate the transfer of heat from the heating element (26) to the water tank (220). Such a thermally conductive medium may be separately attached to the support body (212) or may be integrated into one or more components of the support body (212), such as any one or more of the floor (214) or the sidewalls (216).

[0036] The floor (214) and the sidewalls (216) together define the water tank (220). The water tank (220) is generally configured to hold and contain a fluid therein. Thus, the floor (214) and the sidewalls (216) together are joined by a fluid-tight seal to prevent leakage of the fluid from the water tank (220). The particular size and shape of the water tank (220) in this version generally corresponds to the particular size and shape of the receiver (22). Thus, the water tank (220) is generally made in a rectangular or square shape in this version. However, it should be understood that in other versions, the water tank (220) may be in various alternative shapes, for example, circular, oval, etc. Additionally or alternatively, while the shape of the water tank (220) in this version corresponds to the shape of the receiver (22), such correspondence of shapes need not necessarily be used in other versions. For example, in some versions, the retainer (22) may be rectangular or square in shape and the water tank (220) may be circular.

[0037] As best shown in FIG. 8, the water bath (210) is generally configured to mate with the receiver (22) with the top open area of ​​the water bath (210) being approximately flush with the top surface of the base (10). Additionally, the water bath (210) may be configured to engage the pressure switch (28) when fully seated within the receiver (22). Although not shown, it should be understood that the water bath (210) may include one or more protrusions configured to engage the pressure switch (28). Thus, the sidewall (216) may approximately correspond to the depth of the receiver (22). Additionally, in versions in which the floor (24) of the receiver (22) is angled, the floor (214) of the water tank (220) may be angled as well. Additionally, to allow for such an angled floor (214), the sidewall (216) may be tapered to allow for the above-mentioned flush configuration.

[0038] C. Examples of components included with slide ovens As best shown in FIGS. 9 and 10, the base 10 may, in some circumstances, be used with a slide oven 310 (also referred to as a slide rack oven, enclosed slide heater, or oven). The slide oven 310 is generally configured to be received within the receiver 22 of the base 10 and receive heat from the heating element 26 to dry specimen slides held within the slide oven 310. The slide oven 310 includes a support body 312 (also referred to as a body, support, or base), one or more slide containers 320 (also referred to as a rack container, slide shelf, or holder), and a cap 330 (also referred to as a lid). The support body 312 and cap 330 are configured together to enclose one or more specimen slides held within the slide container 320 for heating using the heating element 26 for drying purposes.

[0039] The support body (312) is configured to be received within the receiver (22) and to house at least a portion of the slide container (320) and the cap (330). The support body (312) includes a floor (314) and a number of side walls (316) extending upwardly from the floor (314). The floor (314) and the side walls (316) together define a generally rectangular or square configuration that is open at the top for receiving at least a portion of the slide container (320) and the cap (330) within the support body. Although not shown, it should be understood that in some versions, the support body (312) may further include a thermally conductive medium to facilitate the transfer of heat from the heating element (26) to each slide container (320). Such a thermally conductive medium may be separately affixed to support body (312) or may be integrated into one or more components of support body (312), such as any one or more of floor (314) or sidewalls (316). Additionally, although not shown, it should be understood that support body (312) may be configured to engage pressure switch (28), either directly with one or more protrusions or indirectly by engaging floor (24).

[0040] Each slide container (320) is configured to receive one or more specimen slides for drying the specimen slides. Each slide container (320) in this version has a generally rectangular configuration and may include multiple slots for receiving one or more specimen slides therein. Although not shown, it is understood that each slide container (320) may receive specimen slides in a variety of orientations, such as horizontal, vertical, or angled. Additionally, while this version is shown as including two slide containers (320), it is understood that in other versions, any suitable number of slide containers (320), such as one, three, or four, may be used.

[0041] The cap (330) is generally configured to nest within the support body (312) to enclose the slide container (320) between the cap (330) and the support body (312). In other words, the cap (330) may be configured to seal the support body (312) to enhance thermal insulation and improve heating / drying efficiency. The cap (330) includes a top portion (332) and a number of side walls (334) that are of a similar but opposite configuration to the floor portion (314) and side walls (316) described above. To facilitate manipulation of the cap (330) by an operator, the top portion (332) includes a grip (336). Although not shown, it should be understood that in some versions, at least a portion of the cap (330) may be transparent to facilitate viewing of the slide container (320) during heating.

[0042] III. Examples of using multiple bases As mentioned above, it may be desirable to use multiple bases (10) to utilize space more efficiently and to increase flexibility. For example, multiple bases (10) may be positioned close to one another such that all bases (10) are powered by only a single power source. This configuration may reduce the total space required by reducing the space between each base (10) and also reducing the space that may be required for additional cabling extending from each base (10) to an independent power source. In addition, flexibility may be improved by allowing the functionality of a given base (10) to be changed without moving the base itself (10) by substituting one accessory component (110, 210, 310) for another accessory component (310, 210, 110). Several exemplary configurations are described below, but it should be understood that various alternative configurations may be used without departing from the principles of operation described herein.

[0043] Figure 11 shows an example of a configuration using multiple bases (10). As can be seen, the configuration includes four bases (10) that are coupled together and powered by a single power source. Specifically, the bases (10) are arranged in a square grid pattern with little or no space between each base (10). This spacing maximizes the use of space by utilizing each recess (46) for the termination of each power cable (350).

[0044] Each power cable (350) connects to a given base (10) so that it provides power to all four bases (10) using only a single power source. In other words, the power cables (350) may be used to daisy-chain the bases (10) together. For example, one power cable (350) extends from the power source to the power input (44) of the first base (10). Then another power cable (350) extends from the power output (42) of the first base (10) to the power input (44) of the second base (10). Another power cable (350) extends from the power output (42) of the second base (10) to the power input (44) of the third base (10). Finally, another power cable (350) extends from the power output (42) of the second base (10) to the power input (44) of the fourth base (10). In this configuration, only four bases (10) are connected using power cables (350), however, it should be understood that the same pattern may be repeated to use as many bases (10) as desired.

[0045] The functionality of each base (10) is facilitated by the various accessory components (110, 210, 310) used with each base (10) in the configuration shown in FIG. 11. Specifically, in this configuration, one base (10) accepts a water bath (210) as an accessory component, and the other three bases (10) accept separate slide dryers (110) as accessory components. With this configuration, the slide dryers (110) are in an L-shaped pattern, with the water bath (210) in one corner (e.g., the left corner). In use, this configuration may be desirable for a right-handed operator, since when the configuration shown in FIG. 11 is positioned to the left of the microtome, the water bath (210) may be positioned closer to the operator's dominant hand. As shown in FIG. 12, this same configuration may be reversed or mirrored for use by a left-handed operator.

[0046] Also, the configurations shown in Figs. 11 and 12 include various power cable (350) arrangements. It should be understood, therefore, that the use of multiple bases (10) together can facilitate flexible power cable (350) arrangements. For example, as shown in Fig. 11, in some configurations, one power cable (350) for communicating with a power source may extend from one side (e.g., the left side) of the configuration. In other configurations, as shown in Fig. 12, the power cable (350) for communicating with a power source may extend from another side (e.g., the rear side) of the configuration. It should be understood, therefore, that each base (10) provides flexibility such that a particular power cable (350) used to communicate with a power source may extend from any suitable side of the base (10) arrangement. Such a feature may be desirable to suit a particular power cable (350) arrangement for a given laboratory environment.

[0047] 11 and 12 show the use of a single water bath (210) and three slide dryers (110), it should be understood that in other configurations, different combinations of ancillary components (110, 210, 310) may be used. For example, one or more of the slide dryers (110) may be used in place of the slide oven (310). Additionally or alternatively, one or more slide dryers (110) may be used in place of the water bath (210) to provide a configuration with more than one water bath (210).

[0048] Figure 13 shows another configuration for use with multiple bases (10) coupled together. As can be seen, this configuration includes three bases (10) coupled together and powered by a single power source. Specifically, the bases (10) are arranged in a linear or line-based pattern with little or no space between each base (10). As mentioned above, this spacing maximizes space usage by utilizing each recess (46) for the termination of each power cable (350).

[0049] Similar to the configurations described above with respect to Figures 11 and 12, the configuration shown in Figure 13 includes a power cable (350) coupled to a single power source, and multiple power cables (350) coupling each base (10) to another base (10). Specifically, one power cable (350) extends from the power source to the power input (44) of the first base (10). Another power cable (350) then extends from the power output (42) of the first base (10) to the power input (44) of the second base (10). Another power cable (350) extends from the power output (42) of the second base (10) to the power input (44) of the third base (10). It should be understood that although in this configuration only three bases (10) are connected using power cables (350), the same pattern may be repeated to use as many bases (10) as desired.

[0050] As discussed above, the functionality of each base (10) is facilitated by the various accessory components (110, 210, 310) used with each base (10) in the configuration shown in FIG. 13. Specifically, in this configuration, one base (10) receives a water bath (210) as an accessory component, and the other two bases (10) receive separate slide dryers (110) as accessory components. With this configuration, the slide dryer (110) is offset along an axis to one side of the configuration, and the water bath (210) is on another side (e.g., the left side) of the configuration. In use, this configuration may be desirable for a right-handed operator, since when the configuration shown in FIG. 13 is positioned to the left of the microtome, the water bath (210) may be positioned closer to the operator's dominant hand. This same configuration may be reversed or mirrored for use by a left-handed operator by positioning the water bath (210) on the opposite side to the configuration shown in FIG. 13.

[0051] 13 illustrates the use of a single water bath (210) and two slide dryers (110), it should be understood that in other configurations, different combinations of ancillary components (110, 210, 310) may be used. For example, one or more of the slide dryers (110) may be used in place of the slide oven (310). Additionally or alternatively, one or more slide dryers (110) may be used in place of the water bath (210) to provide a configuration with more than one water bath (210).

[0052] Regardless of the particular configuration used for the multiple bases (10), it should be understood that the functionality of each base (10) may be changed without the need to reposition each individual base (10). Instead, functionality may be changed by replacing one accessory component (110, 210, 310) with another accessory component (310, 210, 110). Thus, during use, the bases (10) may be initially positioned in a generally desired configuration, such as the square configuration described above with respect to Figures 11 and 12 or the linear configuration described above with respect to Figure 13. Once the generally desired configuration is established, the specific functionality of each of the individual bases (10) may be adjusted as necessary to meet user preferences or operational needs. Additionally or alternatively, different styles of accessory components (110, 210, 310) may be changed without substantially changing functionality. For example, as noted above, some versions of the slide dryer (110) may include different slide support (120) configurations. Thus, one slide dryer (110) may be used in place of another, different slide dryer, such as slide dryers (160, 180) described above.

[0053] Regardless of the specific configuration or function of the bases (10), the bases (10) may generally be positioned close to one another to maximize the use of space. FIG. 14 illustrates the placement of one base (10) relative to another base (10). As can be seen, each receiving body (20) may be positioned adjacent to or near the other receiving body (20) to provide a generally continuous working surface between each base (10). Under each receiving body (20), the recess (46) of each base (10) provides a space through which the power cable (350) may be terminated or run. Thus, the recess (46) of each base (10) allows any power cable (350) to be housed or accommodated without requiring additional space between each base (10).

[0054] IV. Alternative Attachment-Based Examples As mentioned above, the base (10) may generally be configured to be used with specific accessories to facilitate various functional uses of the base (10). In the context of a system, multiple bases (10) may be used with different accessories to provide flexible system configurations. However, in other versions, it may be desirable to dedicate the functionality of each base (10) to a specific function. In other words, a system including separate bases with dedicated functions may be desirable. Dedicated bases such as these may function as one or more of a water bath, a slide dryer, and / or a slide oven. Dedicated bases such as these may be desirable in some situations to reduce product costs, improve ease of manufacturability, and / or provide more integrated control features. Below are described some examples of bases that may be used as bases dedicated to performing specific corresponding functions. However, in some variations, more than one corresponding function may be provided for each base described below. Thus, although bases are described below in the context of being "dedicated," it is contemplated that there may be some scenarios in which the bases described below are not necessarily "dedicated."

[0055] A. Example of a dedicated water bath base FIG. 15 shows a version of a dedicated water bath base (510). This version of the water bath base (510) is generally similar to the combination of the base (10) and the water bath (210) described above. However, unlike the combination of the base (10) and the water bath (210), the water bath base (510) in this example is permanently configured to function as a water bath. Thus, the water bath base (510) is configured with a single function that is not changeable, similar to the base (10) described above. Although water is used to provide the bath in this example, any other suitable type(s) of fluid(s) may be used to provide the bath in addition to or instead of using water.

[0056] Similar to the base (10) described above, the water bath base (510) includes a body (520). However, unlike the body (20) described above, the body (520) in this example omits elements such as the receiver (22) and floor (24). As described in more detail below, certain water bath functional features may be integrated into the body (520) such that elements such as the receiver (22) and floor (24) are not strictly required. However, it should be understood that in other versions, the water bath base (510) may include one or more removable components associated with such water bath functional features. Thus, in some versions, the body (520) may include elements similar to the receiver (22) and floor (24) described above.

[0057] Although body (520) omits elements similar to receiver (22) in this version, body (520) includes a heating element (526), ​​temperature sensor (530), and controller (532) that are similar to heating element (26), controller (32), and sensor (30) described above. Like heating element (26) described above, heating element (526) in this example is generally configured to heat a space defined by body (520). As described in more detail below, body (520) may include certain water bath functional features that may be used in conjunction with heating element (526) to heat a fluid, such as water or other solution.

[0058] Similar to heating element (26) above, heating element (526) may include various heat sources or combinations of heat sources. By way of example only, in some versions, heating element (526) may include one or more heat pads, one or more electrical resistance heating elements, etc. In this version, heating element (526) corresponds to approximately the same area as the space defined by body (520) such that heat may be radiated upwardly into the space defined by body (520). In some versions, at least a portion of heating element (526) may be incorporated into other portions of body (520), such as sidewalls, to radiate heat horizontally or from other directions.

[0059] The temperature sensor (530) is substantially similar to the temperature sensor (30) described above. For example, the temperature sensor (530) is generally configured to detect a temperature within the body (520). As described in more detail below, this temperature detection feature of the temperature sensor (530) may be used to detect a temperature associated with a functional feature of a particular water bath that may be used in conjunction with the heating element (526). While the temperature sensor (530) is shown as a single point in this version, it should be understood that the temperature sensor (530) may include multiple temperature sensors (530) linked in an array. The temperature sensor (530) may be in communication with the controller (532) to detect and communicate to an operator a temperature associated with the interior of the body (520) in real time. As described in more detail below, such real time temperature measurements may be associated with a functional feature of a particular water bath disposed within the body (520).

[0060] The controller 532 includes a display 534, input features 536, and indicators 538. This version of the controller 532 further includes a processor 533 and / or other control circuitry to support use of the display 534, input features 536, and indicators 538, which are in communication with the heating element 526 and the temperature sensor 530. For example, the input features 536 and the temperature sensor 530 may be in communication with the processor 533, such that the processor 533 may receive operational input from the input features 536 and the temperature sensor 530 described above. The processor 533 may also be in communication with the heating element 526, display 534, and indicators 538 to drive the heating element 526, display 534, and indicators 538 based on input received from the input features 536 and the temperature sensor 530. The processor (533) may, in some versions, be used to provide a closed-loop feedback control algorithm for maintaining a portion of the body (520) within a selected temperature range. Similarly, the display (534), input features (536), and indicators (538) may be in communication with the control circuitry to provide operator control or operator feedback.

[0061] Display (534) in this version is substantially similar to display (34) described above. For example, display (534) is generally configured to provide feedback to an operator. In this version, display (534) includes an LED display, an OLED display, or the like. In either case, display (534) may be configured to present operational information to an operator, such as the temperature detected by temperature sensor (530), menu options or other graphical user interface, a timer, etc.

[0062] The input feature (536) in this example may also be substantially similar to the input feature (36) described above. For example, the input feature (536) in this version is configured to allow for user input. In this version, the input feature (536) includes two triangular buttons that may be used to adjust the temperature generated by the heating element (526) up or down. Additionally or alternatively, buttons such as these may be used to cycle through different predetermined modes, which may be shown on the display (534) as the operator cycles through the predetermined modes.

[0063] Similar to indicator (38) described above, this version of indicator (538) is configured to provide certain operational status information to the operator. For example, in this version, indicator (538) includes a single or multi-color LED that may be illuminated differently to communicate operational status to the operator. In some versions, indicator (538) may indicate that a certain temperature (e.g., an operator-set value) has been reached by displaying one of a number of colors. Additionally or alternatively, in some versions, indicator (538) may indicate that a certain temperature has been reached by flashing or blinking at a particular frequency. Additionally or alternatively, in some versions, indicator (538) may also indicate other operational statuses, such as that heating element (526) is active but has not yet reached a predetermined temperature (e.g., preheating).

[0064] The interior of the body (520) defines a functional area (561) configured to support a given function associated with the base (510). In this version, the functional area (561) includes a water bath (560). The water bath (560) is configured similarly to the water bath (210) described above. However, unlike the water bath (210) described above, the water bath (560) in this version is integral with the body (520) and is therefore not removable from the body (520). The water bath (560) is generally configured to function as a fluid reservoir for holding water or other fluid suitable for suspending prepared sections and assisting in the transfer of such prepared sections onto one or more specimen slides.

[0065] The water bath (560) includes a water tank (562) defined by a body (520). The water tank (562) includes a floor (564) and a number of side walls (566) extending upwardly from the floor (564). The floor (564) in this version is disposed above and / or proximate to the heating element (526) such that heat can radiate upwardly from the heating element (526) and into the space defined by the water tank (562). Similarly, the floor (564) in this version is disposed above and / or proximate to the temperature sensor (530) such that the temperature of the fluid in the water tank (562) can be measured using the temperature sensor (530). Although not shown, it should be understood that in some versions, the body (520) may include a thermally conductive medium to facilitate the transfer of heat from the heating element (526) to the water tank (562).

[0066] The floor (564) and sidewalls (566) together define a water tank (562). The water tank (562) is generally configured to hold and contain a fluid therein. Thus, the floor (564) and sidewalls (566) together are joined by a fluid-tight seal to prevent leakage of fluid from the water tank (562). In this version, the particular shape of the water tank (562) is generally made in a rectangular or square shape. However, it should be understood that in other versions, the water tank (562) may be in a variety of alternative shapes, such as a circular, oval shape, etc.

[0067] The top of the water tank (562) is generally flush with the top of the body (520). Thus, the level of the fluid disposed within the water tank (562) may be aligned with the top of the body (520) in some configurations. To facilitate visualization of the surface of the fluid disposed within the water tank (562), an illumination source (570) is included within the body (520). In this version, the illumination source (570) comprises an elongated light bar that extends approximately the length of one or more of the side walls (566). In this version, the illumination source (570) is associated with the control unit (532). However, in other versions, the illumination source (570) may be associated with any one or more sides of the body (520).

[0068] The illumination source (570) is generally configured to direct light onto a surface of the fluid disposed within the water tank (562). The illumination source (570) is configured to emit a generally flat beam at an angle into the interior of the water tank (562). Such a beam may be provided from a variety of sources. For example, in some versions, the illumination source (570) may include an LED light strip, one or more incandescent light bulbs, one or more laser light sources, one or more neon light sources, etc. Additionally, the particular light emitted may be of various colors, such as white light, red, green, blue, and / or other suitable colors. Besides illumination, colors such as these may be varied to provide an operator with an indicator related to the status of the water tank (562).

[0069] As best shown in FIG. 16, the body (520) further defines a recess (546) associated with the bottom and / or sides of the body (520). This version of the recess (546) is similar to the recess (46) described above in that the recess (546) is generally configured to be used in connection with cable management. To facilitate such cable management, the recess (546) may include one or more fastening features similar to the cable management feature (48) described above. However, this version of the recess (546) differs from the recess (46) described above in that it is disposed primarily on the bottom of the body (520) rather than being a depression, notch, or groove in the side of the body (520) similar to the recess (46) described above.

[0070] This version of the recess (546) defines two side legs (548) and one rear leg (550) that intersect approximately in the center of the body (520). Specifically, the legs (548, 550) extend in different directions across the bottom of the body (520) to provide a channel between the center of the body (520) and one or more sides of the body (520). As described in more detail below, this configuration may be used to allow selective association of a cable (580) with a given side of the body (520).

[0071] At the end of each leg (548, 550) opposite the center of the body (520), each leg (548, 550) includes a respective aperture (549, 551) that communicates with a given side of the body (520). Each aperture (549, 551) is oversized relative to the size of each leg (548, 550) to improve access to the respective leg (548, 550) on each side of the body (520). As will be explained in more detail below, the presence of each aperture (549, 551) may be used to facilitate use of the cable (580) for coupling to other features associated with the cable (580).

[0072] In this version, the cable (580) is approximately equal in length to each leg (548, 550). In this version, this length may be desirable to prevent excess length of the cable (580) from tangling under the body (520). It should be appreciated that the cable (580) may be tethered to the body (520) approximately at the center of the body (520) where the legs (548, 550) intersect. Thus, the cable (580) may be easily repositioned from one leg (548, 550) to another leg while still being tethered to the center of the body (520).

[0073] FIG. 17 shows this version of the cable (580) in more detail. As can be seen, the cable (580) includes a multi-function connector (582) having a diameter that corresponds approximately to the size of each of the holes (548, 551). This version of the multi-function connector (582) is configured to facilitate multiple communication functions with the cable (580). For example, the cable (580) may be configured to provide power to the base (510), to transmit power from the base (510), and to transmit electrical inputs and / or outputs to and from the base (510). The multi-function connector (582) may therefore include multiple pins, pin receivers, or other electrical coupling features to facilitate coupling of the cable (580) to other similar cables. As will be described in more detail below, this feature of the multi-function connector (582) may be used to provide power to the base (510) itself, to provide power to other components, and even to control the other components using the controller (532) as a dedicated controller (532) for all components.

[0074] B. Example of dedicated slide dryer base FIG. 18 shows a slide dryer base (610) that may be used in conjunction with the water bath base (510) described above to provide an integrated system for preparing slides. The slide dryer base (610) includes a body (620) and a functional area (661) disposed within a portion of the body (620). Like the body (520) described above, this version of the body (620) includes a heating element (626) and a temperature sensor (630). However, unlike the body (520) described above, this version of the body (620) omits elements similar to the controller (532) and related features. As described in more detail below, the heating element (626) and the temperature sensor (630) are configured to be controlled by the water bath base (510) via the controller (532). Thus, elements similar to the controller (532) are not required in this version of the body (620). However, it should be understood that in some versions, the body (620) may include elements similar to the control (532) to provide additional control of the heating element (626) and temperature sensor (630).

[0075] A functional area (661) is defined by the body (620) and facilitates a given functional feature associated with the base (610). While the functional area (661) can take a variety of forms (e.g., oven, water bath, etc.), in this version, the functional area (661) includes a slide dryer (660). The slide dryer (660) of the slide dryer base (610) is similar to the slide dryer (110) described above. However, unlike the slide dryer (110), the slide dryer (660) in this version may be permanently affixed to the slide dryer base (610). Thus, the function of the slide dryer base (610) is dedicated to slide drying, rather than the other functions described above.

[0076] Similar to the slide dryer (110) described above, this version of the slide dryer (660) includes a slide support (662) that is generally flush with the top of the body (620) and configured to support one or more slides on a surface of the slide support (662). The slide support (662) includes a plurality of angled slats (664) configured to receive one or more specimen slides. Each angled slat (664) is connected to another angled slat (664) by a slide rest (666). Specifically, each slide rest (666) projects vertically or at an angle from one angled slat (664) to another. Additionally, each angled slat (664) is oriented at an oblique angle relative to the horizontal axis of the slide dryer (660) such that a specimen slide may be received at an angle on the surface of each angled slat (664). Each slide rest (666) is thus configured to hold the specimen slide in place to prevent the specimen slide from sliding.

[0077] As discussed above with respect to slide dryer (110), in some instances, slide dryer (660) itself may be oriented at an angle relative to the plane of the top surface of body (620). Such an angled orientation may be in addition to the angles discussed above with respect to angled slats (664). In some versions, this angled configuration may be desirable to encourage fluid to flow away from the angled slats (664) and away from specimen slides disposed on slide dryer (660), further facilitating drying of the specimen slides.

[0078] While in this version, each angled slat (664) is shown as oriented at a specific angle, it should be understood that in other versions, various alternative angles may be used. For example, any one or more of the angles discussed above for the slide dryers (160, 180) may be used in place of the angles shown in FIG.

[0079] As described above, the slide dryer base (610) includes a heating element (626) and a temperature sensor (630). The heating element (626) may be positioned below and / or adjacent to the slide dryer (660) to radiate heat upward into the angled slats (664) to heat one or more specimen slides and promote drying of the one or more specimen slides. Similarly, the temperature sensor (630) may also be positioned below and / or adjacent to the slide dryer (660) to facilitate control of the heating element (626). In this version, this configuration of the temperature sensor (630) may be used to control the temperature of the slide dryer (660) within a predetermined range determined by the control (532) of the water bath base (510).

[0080] As best shown in FIG. 19, the body (620) further defines a recess (646) associated with the bottom and / or sides of the body (620). This version of the recess (646) is similar to the recess (46) described above in that the recess (646) is generally configured to be used in connection with cable management. To facilitate such cable management, the recess (646) may include one or more fastening features similar to the cable management feature (48) described above. However, this version of the recess (646) differs from the recess (46) described above in that it is disposed primarily within the bottom of the body (620) rather than being a depression, notch, or groove in the side of the body (620) similar to the recess (46) described above.

[0081] This version of the recess (646) defines two side legs (648) and one rear leg (650) that intersect approximately at the center of the body (620). Specifically, the legs (648, 650) extend in different directions across the bottom of the body (620) to provide a channel between the center of the body (620) and one or more sides of the body (620). As described in more detail below, this configuration may be used to allow selective association of a cable (680) with a given side of the body (620).

[0082] At the end of each leg (648, 650) opposite the center of the body (620), each leg (648, 650) includes a respective aperture (649, 651) that communicates with a given side of the body (620). Each aperture (649, 651) is oversized relative to the size of each leg (648, 650) to improve access to the respective leg (648, 650) on each side of the body (620). As described in more detail below, the presence of each aperture (649, 651) may be used to facilitate use of cable (680) for coupling to cable (580) of water bath base (510) described above.

[0083] The cable (680) is substantially similar to the cable (580) described above. For example, the present version of the cable (680) defines a length approximately equal to the length of each leg (648, 650). This length may be desirable to prevent excess length of the cable (680) from tangling under the body (620). It should be appreciated that the cable (680) may be tethered to the body (620) approximately at the center of the body (620) where the legs (648, 650) intersect. Thus, the cable (680) may be easily repositioned from one leg (648, 650) to another leg while still being tethered to the center of the body (620).

[0084] Similar to cable 580 described above, this version of cable 680 also includes a multi-function connector 682. Multi-function connector 682 of cable 680 is generally configured to mate with multi-function connector 582 of cable 580 to enable communication of power and / or data between water bath base 510 and slide dryer base 610. The size of multi-function connector 682 corresponds to the size of each of apertures 648, 651. Thus, multi-function connector 682 can be received in each of apertures 648, 651.

[0085] This version of the multi-function connector (682) is configured to facilitate multiple communication functions with the cable (680). For example, the cable (680) may be configured to provide power to the base (610), transmit power from the base (610), and transmit electrical inputs and / or outputs to and from the base (610). The multi-function connector (682) may therefore include multiple pins, pin receivers, or other electrical coupling features to facilitate coupling of the cable (680) to other similar cables, such as the cable (580). As described in more detail below, this feature of the multi-function connector (682) may be used to provide power to the base (610) itself, to provide power to and receive power from other components, and also to facilitate control of the base (610) via other components, such as the water bath base (510).

[0086] C. Example of use in dedicated water bath-based and slide dryer-based systems 20 and 21 show an example of the water bath base (510) and slide dryer base (610) used together in a system. As best shown in FIG. 20, the water bath base (510) and slide dryer base (610) may be coupled together via multi-function connectors (582, 682) on the respective cables (580, 680). In this version, the water bath base (510) may be configured to operate as a leader unit, allowing the control unit (532) to control the operation of both the water bath base (510) and the slide dryer base (610). The slide dryer base (610) may therefore operate as a follower unit, relying on the water bath base (510) for functional control.

[0087] In this version, the water bath base (510) is configured to receive and distribute power to the slide dryer base (610). Power may be provided to the water bath base (510) through a variety of mechanisms. For example, in some versions, the water bath base (510) may include a separate power cable configured to couple to a wall outlet. In versions such as these, the separate power cable may be configured for use in the recess (546) along with the cable (580). Alternatively, the separate power cable may be separate from the recess (546) and may protrude from either side of the body (520), such as the rear or either side. In yet other versions, the cable (580) of the water bath base (510) may include a split section that may be used to couple the water bath base (510) to a power source, such as a wall outlet. In still other versions, the power source may be integrated into the water bath base (510) as a battery.

[0088] As can be seen in FIG. 21, the water bath base (510) and the sliding dryer base (610) can be positioned in various positions relative to each other by routing the respective cables (580, 680) through each recess (546, 646). For example, in one configuration, the sliding dryer base (610) can be positioned on either the left or right side of the water bath base (510) by routing the cables (580, 680) through a given side leg (548, 648). In another configuration, the sliding dryer base (610) can be positioned on the back side of the water bath base (510) by routing the cables (580) through the back leg (550) and routing the cables (680) through a given side leg (648) or back leg (660), depending on the orientation of the sliding dryer base (610).

[0089] Although not shown, it should be understood that in some versions, multiple slide dryer bases (610) may be used in conjunction with one water bath base (510). In such instances, the water bath base (510) may include one or more additional cables (580) to support multiple coupling arrangements. In versions with multiple cables (580), one or more of such multiple cables (580) may be selectively detachable from the water bath base (510) to support various operating modes. Additionally or alternatively, each slide dryer base (610) may include one or more additional cables (680) to enable coupling arrangements between the slide dryer bases (610) and the slide dryer bases (610). Such additional cables (680) may likewise be selectively detachable to support various operating modes.

[0090] Similar to the configuration described above with respect to Figure 21, the arrangement with multiple sliding dryer bases (610) can take a variety of configurations. For example, in some configurations, the water bath base (510) may be centrally located with separate sliding dryer bases (610) on either side and / or rear. In other configurations, the water bath base (510) may be located on one side with multiple sliding dryer bases (610) located from a single side or rear of the water bath base (510).

[0091] V. Combination Examples The following examples relate to various non-exhaustive ways in which the teachings herein may be combined or applied. The following examples are not intended to limit the scope of any "claims" that may be presented at any time in this application or in any subsequent application following this application. No disclaimers are intended. The following examples are provided for illustrative purposes only. It is contemplated that the various teachings herein may be arranged and applied in many other ways. It is also contemplated that some variations may omit certain features referred to in the examples below. Thus, unless expressly indicated otherwise later by the inventor or by the intended inventor's successors, etc., none of the aspects or features referred to below should be considered critical. If any "claims" are presented in this application or in any subsequent application related to this application that include additional features beyond those referred to below, those additional features should not be presumed to have been added for any reason related to patentability.

[0092] Example 1 1. A system comprising: a base including a receiving body having a receiver and a heating element proximate to the receiver, and a control unit having one or more user interface features configured to control the heating element; a first accessory component configured to process one or more tissue samples after sectioning using a microtome, the first accessory component further configured to be received within the receiver of the base; and a second accessory component configured to be received within the receiver of the base, the first accessory component configured for different processing functions of one or more tissue samples after sectioning using the microtome relative to the second accessory component, the first accessory component and the second accessory component configured to be interchangeably received within the receiver of the base.

[0093] Example 2 The system of example 1, wherein the first accessory component is configured to dry one or more specimen slides.

[0094] Example 3 The system of example 2, wherein the first attachment component has a plurality of angled slats configured to receive the one or more specimen slides on a surface of each angled slat.

[0095] Example 4 The system of example 2, wherein the first accessory component has a cap configured to enclose the one or more specimen slides within the first accessory component.

[0096] Example 5 The system of Example 4, wherein the first accessory component further comprises one or more slide containers, the one or more slide containers configured to hold the one or more specimen slides.

[0097] Example 6 The system of any one or more of Examples 1-5, wherein the second accessory component includes a fluid tank configured to hold a fluid.

[0098] Example 7 The system of any one or more of Examples 1 to 6, wherein the heating element is configured to be in thermal communication with both the first accessory component or the second accessory component when either the first accessory component or the second accessory component is received within the receiver of the base.

[0099] Example 8 The system of any one or more of Examples 1-7, further comprising a third accessory component, wherein the first accessory component, the second accessory component, and the third accessory component each have a different configuration relative to one another.

[0100] Example 9 The system of Example 8, wherein both the third accessory component and the first accessory component are configured to dry one or more specimen slides.

[0101] Example 10 A system described in any one or more of Examples 1 to 9, wherein the base is a first base, the system further includes a second base, the second base includes a receiving body having a receiver, and the receiver of the second base is configured to interchangeably receive the first accessory component and the second accessory component.

[0102] Example 11 The system of Example 10, wherein the first base is in communication with the second base, and the control unit of the first base is configured to control one or more functions of the second base.

[0103] Example 12 A system described in any one or more of Examples 1 to 11, wherein the receiver of the base is configured to receive the first accessory component or the second accessory component flush with the top surface of the base.

[0104] Example 13 The system of any one or more of Examples 1-12, wherein the base further includes a support platform extending downwardly from a lower portion of the receiving body, a portion of the support platform being recessed relative to the receiving body to define a recess.

[0105] Example 14 The system of Example 13, wherein the support platform includes a power input and a power output, both of which are positioned within the recess.

[0106] Example 15 The system of any one or more of Examples 1-14, wherein the first accessory component and the second accessory component are selected from the group consisting of a slide dryer, a water bath, and a slide oven.

[0107] Example 16 11. A kit comprising: a base having a receiving body including a floor and a receiver having a heating element proximate to the floor, a controller having one or more user interface features configured to control the heating element, a support extending from the receiving body, and a power interface configured to provide power to the heating element; and a plurality of accessory components, each configured to be replaceably received within the receiver of the receiving body, the plurality of accessory components including a first accessory component configured to hold fluid for processing of the one or more sectioned tissue samples, and a second accessory component configured to hold one or more specimen slides for heating by the heating element.

[0108] Example 17 The kit of example 16, wherein the receiver is recessed within a portion of the receiving body.

[0109] Example 18 The kit of example 16, wherein the heating element is disposed beneath the floor.

[0110] Example 19 The kit of example 16, wherein the heating element is configured to radiate heat into a space defined by the receiver.

[0111] Example 20 11. A system comprising: a first base including a first receiving body having a first receiver and a first heating element proximate to the first receiver, and a controller having one or more user interface features configured to control the first heating element; a second base including a second receiving body having a second receiver and a second heating element proximate to the second receiver, the controller of the first base configured to control the second heating element while controlling the first heating element; a first accessory component configured to process one or more tissue samples after sectioning using a microtome, the first accessory component further configured to be received within the first receiver or the second receiver; and a second accessory component configured to be received within the first receiver or the second receiver, the first accessory component configured for a different processing function of one or more tissue samples after sectioning using the microtome relative to the second accessory component.

[0112] V.Miscellaneous rules It should be noted that as used herein, "couple," "coupled," "coupled," or other variations of the word coupling may refer to either an indirect or direct coupling. For example, when a first component is "coupled" to a second component, the first component may be either indirectly coupled to the second component through another component, or directly coupled to the second component.

[0113] The methods disclosed herein include one or more steps or actions for achieving the described method. The method steps and / or actions may be interchanged with one another without departing from the scope of the claims. In other words, unless a specific order of steps or actions is required for the proper operation of the described method, the order and / or use of specific steps and / or actions may be changed without departing from the scope of the claims.

[0114] As used herein, the term "plurality" means two or more. For example, a plurality of components refers to two or more components. The term "determining" encompasses a wide variety of actions, such that "determining" can include calculating, computing, processing, deriving, considering, examining (e.g., looking in a table, database, or another data structure), ascertaining, and the like. "Determining" can also include receiving (e.g., receiving information), accessing (e.g., accessing data in a memory), and the like. "Determining" can also include resolving, selecting, electing, establishing, and the like.

[0115] The phrase "based on" does not mean "based only on," unless expressly stated otherwise. In other words, the phrase "based on" describes both "based only on" and "based at least on."

[0116] It should be understood that any of the variations of the devices or components described herein may include various other features in addition to or in place of those described above. Also, by way of example only, any of the devices herein may include one or more of the various features disclosed in any of the various references incorporated by reference herein. Various suitable ways in which such teachings may be combined will be apparent to those skilled in the art.

[0117] It should be understood that any one or more of the teachings, expressions, embodiments, examples, etc. described herein may be combined with any one or more of the other teachings, expressions, embodiments, examples, etc. described herein. Thus, the above teachings, expressions, embodiments, examples, etc. should not be considered in isolation from one another. Various suitable ways in which the teachings herein may be combined will be readily apparent to those of skill in the art in view of the teachings herein. Such modifications and variations are intended to be included within the scope of the claims.

[0118] It should be recognized that any patent, publication, or other disclosure material referred to as being incorporated herein by reference in whole or in part is incorporated herein only to the extent that the incorporated material does not conflict with existing definitions or other disclosure material set forth in this disclosure. Thus, and to the extent necessary, the disclosure expressly set forth herein takes precedence over any conflicting material incorporated herein by reference. Any material, or portion thereof, referred to as being incorporated herein by reference but which conflicts with existing definitions or other disclosure material set forth herein, is incorporated only to the extent that no conflict arises between the incorporated material and the existing disclosure material.

[0119] Although various embodiments of the present invention have been shown and described, further adaptations of the methods and systems described herein may be achieved by appropriate modifications by those skilled in the art without departing from the scope of the present invention. Although some of such potential modifications have been mentioned, others will be apparent to those skilled in the art. For example, the examples, embodiments, geometries, materials, dimensions, ratios, steps, etc. described above are illustrative and not required. Thus, it is understood that the scope of the present invention should be considered in conjunction with the following "claims" and is not limited to the details of structure and operation shown and described in the specification and drawings.

[0120] [Embodiment] (1) A system comprising: (a) a base, (i) a receiving body including a receiver and a heating element proximate to the receiver; and (ii) a control unit, the control unit including one or more user interface features configured to control the heating element; The base comprising: (b) a first accessory component configured to process one or more tissue samples after sectioning using a microtome, the first accessory component being further configured to be received within the receiver of the base; and (c) a second accessory component configured to be received within the receiver of the base, the first accessory component configured for different processing functions of one or more tissue samples after sectioning using the microtome on the second accessory component, the first accessory component and the second accessory component configured to be interchangeably received within the receiver of the base; The system comprising: (2) The system of embodiment 1, wherein the first accessory component is configured to dry one or more specimen slides. (3) The system of embodiment 2, wherein the first attachment component has a plurality of angled slats, the plurality of angled slats configured to receive the one or more specimen slides on a surface of each angled slat. (4) The system of embodiment 2, wherein the first accessory component has a cap configured to enclose the one or more specimen slides inside the first accessory component. (5) The system of embodiment 4, wherein the first accessory component further comprises one or more slide containers, the one or more slide containers configured to hold the one or more specimen slides.

[0121] (6) The system of any one or more of embodiments 1 to 5, wherein the second accessory component includes a fluid tank configured to hold a fluid. (7) The system of any one or more of embodiments 1 to 6, wherein the heating element is configured to be in thermal communication with both the first accessory component or the second accessory component when either the first accessory component or the second accessory component is received within the receiver of the base. (8) The system described in any one or more of embodiments 1 to 7, further comprising a third accessory component, wherein the first accessory component, the second accessory component, and the third accessory component each have a different configuration relative to one another. (9) The system of embodiment 8, wherein both the third accessory component and the first accessory component are configured to dry one or more specimen slides. (10) The system described in any one or more of embodiments 1 to 9, wherein the base is a first base, the system further includes a second base, the second base includes a receiving body having a receiver, and the receiver of the second base is configured to interchangeably receive the first accessory component and the second accessory component.

[0122] (11) The system of embodiment 10, wherein the first base communicates with the second base, and the control unit of the first base is configured to control one or more functions of the second base. (12) A system described in any one or more of embodiments 1 to 11, wherein the receiver of the base is configured to receive the first accessory component or the second accessory component flush with an upper surface of the base. (13) The system of any one or more of embodiments 1 to 12, wherein the base further includes a support platform extending downwardly from a lower portion of the receiving body, a portion of the support platform being recessed relative to the receiving body to define a recess. (14) The system of embodiment 13, wherein the support platform includes a power input and a power output, both of the power input and the power output being positioned within the recess. (15) The system of any one or more of embodiments 1 to 14, wherein the first and second auxiliary components are selected from the group consisting of a slide dryer, a water bath, and a slide oven.

[0123] (16) (a) A base, (i) a receiving body, the receiving body including a receiver having a floor and a heating element proximate to the floor; (ii) a control having one or more user interface features configured to control the heating element; (iii) a support extending from the receiving body; and (iv) a power interface configured to provide power to the heating element; The base comprising: (b) a plurality of accessory components, each accessory component configured to be interchangeably received within the receiver of the receiving body; The plurality of accessory components include: (i) a first accessory component configured to hold a fluid for processing of the one or more sectioned tissue samples; and (ii) a second attachment component configured to hold one or more specimen slides for heating by said heating element; the plurality of accessory components including: Including the kit. (17) The kit of embodiment 16, wherein the receiver is recessed within a portion of the receiving body. (18) The kit of claim 16, wherein the heating element is disposed beneath the floor. (19) The kit of claim 16, wherein the heating element is configured to radiate heat into a space defined by the receiver. (20) A system comprising: (a) A first base, (i) a first receiving body, the first receiving body including a first receiver and a first heating element proximate to the first receiver; and (ii) a control unit, the control unit including one or more user interface features configured to control the first heating element; The first base comprising: (b) a second base, the second base including a second receiving body having a second receiver and a second heating element proximate to the second receiver, the controller of the first base configured to control the second heating element while controlling the first heating element; (c) a first accessory component configured to process one or more tissue samples after sectioning using a microtome, the first accessory component being further configured to be received within the first receiver or the second receiver; (d) a second accessory component configured to be received within the first receiver or the second receiver, the first accessory component configured for a different processing function of one or more tissue samples after sectioning using the microtome on the second accessory component; and The system comprising:

Claims

1. 1. A system comprising: (a) a base, (i) a receiving body, the receiving body including a receiver and a heating element proximate to the receiver; and (ii) a control unit including one or more user interface features configured to control the heating element; The base comprising: (b) a first accessory component configured to process one or more tissue samples after sectioning using a microtome, the first accessory component being further configured to be received within the receiver of the base; and (c) a second attachment component configured to be received within the receiver of the base, the first attachment component configured for different processing functions of one or more tissue samples after sectioning using the microtome on the second attachment component, the first attachment component and the second attachment component configured to be interchangeably received within the receiver of the base; The system comprising:

2. The system of claim 1 , wherein the first accessory component is configured to dry one or more specimen slides.

3. The system of claim 2 , wherein the first attachment component has a plurality of angled slats configured to receive the one or more specimen slides on a surface of each angled slat.

4. The system of claim 2 , wherein the first attachment component comprises a cap configured to enclose the one or more specimen slides within the first attachment component.

5. The system of claim 4 , wherein the first accessory component further comprises one or more slide containers, the one or more slide containers configured to hold the one or more specimen slides.

6. The system of any one or more of the preceding claims, wherein the second annular component comprises a fluid reservoir configured to hold a fluid.

7. The system of claim 1 , wherein the heating element is configured to be in thermal communication with both the first accessory component or the second accessory component when either the first accessory component or the second accessory component is received within the receiver of the base.

8. The system of claim 1 , further comprising a third accessory component, wherein the first accessory component, the second accessory component, and the third accessory component each have a different configuration relative to one another.

9. The system of claim 8 , wherein both the third accessory component and the first accessory component are configured to dry one or more specimen slides.

10. 2. The system of claim 1, wherein the base is a first base, and the system further includes a second base, the second base including a receiving body having a receiver, the receiver of the second base configured to interchangeably receive the first accessory component and the second accessory component.

11. The system of claim 10 , wherein the first base is in communication with the second base, and the control unit of the first base is configured to control one or more functions of the second base.

12. The system of claim 1 , wherein the receiver of the base is configured to receive the first attachment component or the second attachment component flush with a top surface of the base.

13. The system of claim 1 , wherein the base further includes a support platform extending downwardly from a lower portion of the receiving body, a portion of the support platform being recessed relative to the receiving body to define a recess.

14. The system of claim 13 , wherein the support platform includes a power input and a power output, both of the power input and the power output being positioned within the recess.

15. 2. The system of claim 1, wherein the first and second ancillary components are selected from the group consisting of a slide dryer, a water bath, and a slide oven.

16. (a) a base, (i) a receiving body including a receiver having a floor and a heating element proximate to the floor; (ii) a control having one or more user interface features configured to control the heating element; (iii) a support extending from the receiving body; and (iv) a power interface configured to provide power to the heating element; The base comprising: (b) a plurality of accessory components, each accessory component configured to be interchangeably received within the receiver of the receiving body; The plurality of accessory components include: (i) a first accessory component configured to hold a fluid for processing of the one or more sectioned tissue samples; and (ii) a second attachment component configured to hold one or more specimen slides for heating by the heating element; the plurality of accessory components including: Including the kit.

17. The kit of claim 16 , wherein the receiver is recessed within a portion of the receiving body.

18. 17. The kit of claim 16, wherein the heating element is disposed beneath the floor.

19. The kit of claim 16 , wherein the heating element is configured to radiate heat into a space defined by the receiver.

20. 1. A system comprising: (a) a first base, (i) a first receiving body including a first receiver and a first heating element proximate to the first receiver; and (ii) a control unit, the control unit including one or more user interface features configured to control the first heating element; The first base comprising: (b) a second base, the second base including a second receiving body having a second receiver and a second heating element proximate to the second receiver, the controller of the first base configured to control the second heating element while controlling the first heating element; (c) a first accessory component configured to process one or more tissue samples after sectioning using a microtome, the first accessory component being further configured to be received within the first receiver or the second receiver; (d) a second accessory component configured to be received within the first receiver or the second receiver, the first accessory component configured for a different processing function of one or more tissue samples after sectioning using the microtome on the second accessory component; and The system comprising:

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