Antiviral composition and its use

Abstract

The present invention discloses a composition containing acetic acid, phosphoric acid, and citric acid, which exhibits high antiviral activity. In some embodiments, the composition contains 1 to 30% by weight of acetic acid, 0.2 to 10% by weight of citric acid, and 0.01 to 1.0% by weight of phosphoric acid. The composition can be used to produce several edible products such as confectionery and chewing gum, and non-edible products, for example, toothpaste, shampoo, etc., or products for sterilizing cloth, tools, air, etc. More specifically, the invention discloses a composition containing acetic acid, citric acid, and phosphoric acid in chewing gum for its use as a drug and for its use in the treatment of viral and / or bacterial infections, and the virus is an enveloped virus such as a coronavirus.

Description

Technical Field

[0001] The present invention relates to a virucidal chewing gum incorporating a combination of acids suitable for consumption and also having optimized sensory properties.

Background Art

[0002] Viral infectious diseases typically develop from the emergence of new variants of known infectious viruses. Viral transmission can occur at an unprecedented rate through human-to-human contact or contact with contaminated surfaces, and it is essential to find effective therapies as well as bactericidal or disinfectant agents.

[0003] Depending on the type of contaminated surface and environmental conditions, it is known that viruses can survive on surfaces for at least 5 minutes and up to 28 days. As shown by Kampf et al. (J. Hosp. Infect. 2020, 104(3), 246 - 251), human coronaviruses, such as SARS (severe acute respiratory syndrome) coronavirus, Middle East respiratory syndrome (MERS) coronavirus or human endemic coronavirus (HCoV), survive on inert surfaces such as metal, glass or plastic for up to 9 days. In these cases, a significant amount of virus can be transmitted with a 5 - second contact between the hand and the surface, and the virus can be transmitted by touching the oral mucosa, nasal mucosa or conjunctiva of the eye.

[0004] Regarding the treatment of viral infections, most of them contain antiviral drugs targeted at parenteral administration routes, especially in the form of capsules or tablets. In the most severe cases, the parenteral administration route provides an effective alternative for easily administering higher doses of antiviral pharmaceuticals. Furthermore, the combined administration of different antiviral drugs in tablet form is another typically preferred option, especially for patients who do not respond to typical antiviral monotherapies.

[0005] However, these treatment options usually cause serious side effects, especially when the drugs are administered at high doses. For example, oral administration of antiviral drugs in tablet form can lead to short-term or long-term side effects and may affect the digestive system when administered at high doses. This can potentially lead to reduced patient compliance, especially when long-term treatment is required.

[0006] Furthermore, the combined administration of antiviral drugs, whether oral, especially in tablet form, or parenteral, can result in drug interactions and can cause more serious long-term side effects in patients.

[0007] Unlike antiviral drugs, which typically disrupt the virus's replication ability, different types of compounds known as virucidal agents directly inactivate the virus, so that due to modification of the virus's surface structure or destruction of the virus, the virus cannot infect host cells. However, virucidal agents such as bleach, hydrochloric anhydride, or even soap water are not suitable for use in the human body due to the potential for health risks. Thus, their use is restricted to surface disinfection. However, considering the potential effectiveness of virucidal agents against viral infections in humans, it is desirable to find a new class of agents with a similar mode of action but without the drawbacks associated with conventional virucidal agents.

[0008] In this scenario, there is clearly a need for a new and effective virucidal agent that can be used in therapeutic applications, especially for the treatment of infected patients, which significantly reduces the risk of viruses that can spread by contact with infected surfaces or aerosols and reach the oral / nasal environment. Furthermore, it is desirable to obtain a new virucidal formulation in which the side effects typically associated with the classical routes of administration of antiviral drugs are dramatically reduced.

[0009] Moreover, the gum is known from document US20070237805A1 regarding chewing gum and confectionery compositions for improving dental hygiene, particularly of mammals, especially humans. In particular, the compositions described in said document may include a gum base or carrier, a sweetener, casein phosphopeptide-calcium phosphate (CPP-ACP) and a food-grade acid. The addition of flavors, many of which are inherently acidic, is routine in gum manufacture, but this poses a risk of tooth decay or aversion. For this reason, according to this document, a compound targeting the remineralization of mammalian tooth surfaces is added.

Prior Art Documents

Patent Documents

[0010]

Patent Document 1

Summary of the Invention

Means for Solving the Problems

[0011] To overcome the drawbacks of the state of the art, the present invention proposes a chewing gum containing 1 to 30% w / v of acetic acid, 0.2 to 10% w / v of citric acid, 0.01 to 1.0% w / v of phosphoric acid and, % w / v relates to the weight per total volume of the composition.

[0012] The inventive antiviral chewing gum object solves the drawbacks of the state of the art. On the one hand, it shows significant antiviral capacity by the combination of GRAS acids.

[0013] In some embodiments, acetic acid is included in an amount of 2 to 3% w / v, preferably 2.5%, citric acid is included in an amount of 1.5 to 2% w / v, preferably 1.75%, and phosphoric acid is included in an amount of 0.05 to 0.07% w / v, preferably 0.06%.

[0014] In particular, this combination of an acid and chewing gum at a specific concentration has been shown to lead to an effective antiviral release rate upon chewing of the gum. However, in combination with this ability, the concentration has been shown to be acceptable to most users from a sensory perspective, which is an essential condition for the user to continuously maintain the gum in his / her mouth and lead to the desired effect.

[0015] This special selection corresponds to a composition containing the least added acids, i.e., the total of acetic acid, citric acid and phosphoric acid is lower, which has been proven to be acceptable by all people who have tried the composition, and this has maintained the antiviral ability at about 99% throughout.

[0016] Furthermore, the claimed set has been shown to be very stable under storage conditions.

[0017] The chewing gum may comprise: - an elastomeric polymer, preferably a specially purified elastomeric polymer, - a resin, - a purified wax, - a plant fatty acid glycerol ester, - a fully hydrogenated vegetable oil, - talc, a maximum amount of 0.1% antioxidant, preferably TCPHN.

[0018] These components are known and those skilled in the art will know how to select the concentration ranges of each of them.

[0019] The composition may further optionally incorporate one or more chewing gum components such as sweeteners, sugars, flavorings, taste-masking agents and vitamins.

[0020] The base gum is held in the mouth during the chewing period and generally contains elastomers, resins, fats, oils, waxes, softeners and inorganic fillers. Examples of suitable elastomers include, for example, polyisobutylene, isobutylene-isoprene copolymer, styrene-butadiene rubber, and also natural latex types, but are not limited thereto. Examples of suitable resins include, but are not limited to, the following: terpenes and polyvinyl acetate resins. Exemplary fats and oils include, but are not limited to, animal fats, hydrogenated or partially hydrogenated vegetable oils, or coconut butter. Typically used waxes include paraffin, natural and microcrystalline waxes, such as beeswax or carnauba. A typical inorganic filler can be talc. The base gum can optionally additionally contain at least one softener, such as glycerol monostearate or glycerol triacetate. The base gum can also contain additional material components, such as antioxidants, colorants and / or emulsifiers. All commercially available base gums recognized as safe for human consumption can be contemplated for the purposes of the compositions of the present invention.

[0021] Conveniently, chewing gum incorporates one or more ingredients such as sweeteners, sugars, flavorings, taste-masking agents and vitamins.

[0022] Sweeteners can be added to chewing gum to increase the perception of sweetness. Examples of suitable sweeteners include, but are not limited to, sorbitol, xylitol, mannitol or maltitol.

[0023] As described above, the chewing gum composition can further contain at least one sugar, such as glucose, sucrose, fructose, invert sugar, maltose, lactose or any mixture thereof.

[0024] The flavoring agents that can be added to the chewing gum composition can have various flavors. Particularly preferred flavoring agents are liquids or powders, or encapsulated flavors. Suitable flavoring agents include, but are not limited to, mint, vanilla, strawberry, orange or citrus flavors. Further, they can provide the advantage of masking the taste of the composition, even the gelatin taste.

[0025] Suitable vitamins in the chewing gum composition include, according to some embodiments, vitamin C, vitamin B2, vitamin B6, vitamin B12, vitamin E, vitamin D, vitamin A, biotin, niacin, thiamine, pantothenic acid, folic acid or any mixture thereof.

[0026] The taste-masking agent can hide a particular aspect of the taste of the chewing gum composition, such as sour taste. In some embodiments, the taste-masking agent includes at least one of the flavoring agents and / or sweeteners shown above. Some suitable high-intensity taste-masking agents include polyol sweeteners, which can be selected from the list consisting of dextrose, sucrose, maltose and lactose. In some embodiments, suitable high-intensity taste-masking agents can be selected from the group consisting of sucralose, neotame, aspartame, acesulfame salt, alitame, saccharin and its salts, cyclamic acid and its salts, glycyrrhizin, dihydrochalcone, such as NHDC, thaumatin, monellin, stevioside, aspartame-acesulfame salt and any mixture thereof. In certain embodiments, the taste-masking agent was selected from the group consisting of dextrose, sucrose, fructose, lactose, sucralose, neotame, aspartame, acesulfame salt, alitame, saccharin and its salts, cyclamic acid and its salts, glycyrrhizin, dihydrochalcone (e.g., NHDC), thaumatin, monellin, stevioside, aspartame-acesulfame salt and any combination thereof.

[0027] The chewing gum can be manufactured according to all conventional methods. As an example, it can be produced by directly mixing the base gum with acetic acid, citric acid, and phosphoric acid as well as any other components defined above.

[0028] In other embodiments, the chewing gum can be manufactured by the continuous or simultaneous addition of various material components in a commercially available mixer known in the art. After the material components are mixed, the gum mass is taken out of the mixer, molded into the desired shape, for example, a sheet is produced using a roller, which is cut into slices, extruded into pieces, or molded into shaped objects or tablets. The base gum can be melted and the material components can be mixed after being added to the operating mixer. The flavoring agent can be melted inside the same mixer. Additional material components can also be added at this time. For example, an additional portion of the sweetener can be added to the mixer. High-intensity flavoring agents are typically added in the final portion. High-intensity sweeteners can preferably be added in subsequent manufacturing steps after the flavor has been added.

[0029] Throughout the description and claims, the word "comprising" or both of its variants "consisting of" do not exclude other technical terms, material components, or processes. Additional advantages and features of the invention will become apparent to those skilled in the art from an examination of those in the description, or may be learned by practicing the invention without undue burden.

Embodiments for Carrying Out the Invention

[0030] The following experimental examples and results are provided as non-limiting illustrations and are not considered to limit the invention.

[0031] Example 1 Study on the antiviral properties of the chewing gum according to the present invention The antiviral activity in the context of the present invention should be understood as the inactivation properties of the composition. The composition of the first aspect of the invention contains acetic acid, citric acid, and phosphoric acid.

[0032] The antiviral activity was measured under clean conditions and on Modified Vaccinia Virus Ankara (MVVA) in accordance with the EN 14476:2013+A2:2019 standard, whereby the results of the antiviral activity against viruses with envelopes such as HBV, HCV, HIV, and viruses from other families, such as Orthomyxoviruses (including all human influenza viruses), Coronaviridae (including MERS-CoV, SARS-CoV-1, and SARS-CoV-2), and Filoviruses including Ebola virus were evaluated (Eggers M et al. Povidone-iodine hand washes and hand rub products showed excellent in vitro antiviral efficacy against the new European test viruses Ebola virus and Modified Vaccinia Virus Ankara, viruses with envelopes. BMC Infect Dis. 2015; 15:375).

[0033] This test demonstrated that after 1 minute of exposure to the following compositions (undiluted, 50% dilution, 20% dilution, and 10% dilution), 99.99% of all virus particles were destroyed and were unable to infect BHK-21 cells cultured at 37°C: VS1 (Viral Inactivation Solution 1) composed of the following: - Acetic acid at a concentration of 525 mg / ml (or 52.5% or 52.5 g / 100 ml), - Citric acid at a concentration of 20 mg / ml (or 2% or 2 g / 100 ml), - Phosphoric acid at a concentration of 6 mg / ml (or 0.6% or 0.6 g / 100 ml), - water. VS2 (Viral Inactivation Solution 2): 50% dilution composed of the following: - Acetic acid at a concentration of 262 mg / ml (or 26.25% or 26.25 g / 100 ml), - Citric acid at a concentration of 10 mg / ml (or 1% or 1 g / 100 ml), - Phosphoric acid at a concentration of 3 mg / ml (or 0.3% or 0.3 g / 100 ml). VS3 (Viral Inactivation Solution 3): 20% dilution composed of the following: - Acetic acid at a concentration of 105 mg / ml (or 10% or 10 g / 100 ml), - Citric acid at a concentration of 4 mg / ml (or 4% or 4 g / 100 ml), - Phosphoric acid at a concentration of 1.2 mg / ml (or 0.12% or 0.12 g / 100 ml), - water. VS4 (Virus - killing solution 4) composed of the following: 10% dilution: - Acetic acid at a concentration of 52.5 mg / ml (or 5.25% or 5.25 g / 100 ml), - Citric acid at a concentration of 2 mg / ml (or 2% or 2 g / 100 ml), - Phosphoric acid at a concentration of 0.6 mg / ml (or 0.06% or 0.06 g / 100 ml), - water. VS5 (Virus - killing solution 5) composed of the following: 0.05% dilution: - Acetic acid at a concentration of 0.26 mg / ml (or 0.02% or 0.02 g / 100 ml), - Citric acid at a concentration of 0.01 mg / ml (or 0.001% or 0.001 g / 100 ml), - Phosphoric acid at a concentration of 0.003 mg / ml (or 0.0003% or 0.0003 g / 100 ml), - water.

[0034] The 0.05% dilution showed some virus - killing activity after 1 - minute exposure to BHK - 21 cells, and thus was considered non - virus - killing at this dilution factor.

[0035] Another test on the virus - killing activity of the composition composed of the following: VS6 (Virus - killing solution 6) composed of the following: - Acetic acid at a concentration of 250 mg / ml (or 25% or 25 g / 100 ml), - Citric acid at a concentration of 10 mg / ml (or 1% or 1 g / 100 ml), - Phosphoric acid at a concentration of 30 mg / ml (or 3% or 3 g / 100 ml), - water.

[0036] This test was performed directly on the SARS-CoV-2 GT4 CNS virus, which was exposed to the composition for 5 minutes and incubated with Vero E6 cells, and a 97 to 99% (99.9%?) reduction in the infectivity of the Vero E6 cells by the SARS-CoV-2 virus was obtained.

[0037] Another test on the antiviral activity of a composition consisting of the following: VS7 (Viral Inactivation Solution 7) consisting of the following: - Acetic acid at a concentration of 52.5 mg / ml (or 5.25% or 5.25 g / 100 ml), - Citric acid at a concentration of 2 mg / ml (or 0.2% or 0.2 g / 100 ml), - Phosphoric acid at a concentration of 0.6 mg / ml (or 0.6% or 0.6 g / 100 ml) - water.

[0038] This test was performed directly on the SARS-CoV-2 GT4 CNS virus, which was exposed to the composition for 5 minutes and incubated with Vero E6 cells, and a 97 to 99% reduction in the infectivity of the Vero E6 cells by the SARS-CoV-2 virus was obtained.

[0039] Another test on the antiviral activity of a composition consisting of the following: VS8 (Viral Inactivation Solution 8) consisting of the following: - Acetic acid at a concentration of 25 mg / ml (or 2.5% or 2.5 g / 100 ml), - Citric acid at a concentration of 17.5 mg / ml (or 1.75% or 1.75 g / 100 ml), - Phosphoric acid at a concentration of 0.6 mg / ml (or 0.06% or 0.06 g / 100 ml) - water.

[0040] This test was performed directly on the SARS-CoV-2 GT4 CNS virus, which was exposed to the composition for 5 minutes and incubated with Vero E6 cells, and a 97 to 99% reduction in the infectivity of the Vero E6 cells by the SARS-CoV-2 virus was obtained.

[0041] Another test on the antiviral activity of the composition composed of the following: VS9 (Viral-killing Solution 9) composed of the following: - Sodium acetate at a concentration of 71.7 mg / ml (or 7.17% or 7.17 g / 100 ml), - Citric acid at a concentration of 2 mg / ml (or 0.2% or 0.2 g / 100 ml), - Phosphoric acid at a concentration of 0.6 mg / ml (or 0.06% or 0.06 g / 100 ml), - water.

[0042] This test was carried out directly on the SARS-CoV-2 GT4 CNS virus, which was exposed to the composition for 5 minutes and incubated with Vero E6 cells, and a 40% reduction in the infectivity of Vero E6 cells by the SARS-CoV-2 virus was obtained.

[0043] Another test on the antiviral activity of the composition composed of the following: VS10 (Viral-killing Solution 10) composed of the following: - Acetic acid at a concentration of 25 mg / ml (or 2.5% or 2.5 g / 100 ml), - Citric acid at a concentration of 2 mg / ml (or 0.2% or 0.2 g / 100 ml), - Phosphoric acid at a concentration of 0.6 mg / ml (or 0.06% or 0.06 g / 100 ml), - water.

[0044] This test was carried out directly on the SARS-CoV-2 GT4 CNS virus, which was exposed to the composition for 5 minutes and incubated with Vero E6 cells, and a 75 - 80% reduction in the infectivity of Vero E6 cells by the SARS-CoV-2 virus was obtained.

[0045] These results are summarized in the following table:

Table 1

[0046] Most of the chewing gum compositions based on combinations of three acids gave good results in relation to their antiviral ability, but it was proven that VS8 chewing gum had the best sensory results, mainly because it contained the least amount of acid.

[0047] Study on the release profile of chewing gum according to the present invention Chewing gum having a VS8 composition composed of the following: - Acetic acid at a concentration of 25 mg / ml (or 2.5% or 2.5 g / 100 ml), - Citric acid at a concentration of 17.5 mg / ml (or 1.75% or 1.75 g / 100 ml), - Phosphoric acid at a concentration of 0.6 mg / ml (or 0.06% or 0.06 g / 100 ml).

[0048] Furthermore, it exhibits 97 to 99% antiviral activity in a saliva secretion environment of 4 ml / min at the chewing gum compatible acid concentration, and provides an experimentally determined release from the following base gum: - 25% acetic acid / min, - 35% citric acid / min, - 50% phosphoric acid / min.

[0049] As described above, the concentration of the chewing gum components was adjusted to the release values for each of the three acids so that the concentration represented by VS8 was reached in the oral cavity during the first minute of chewing. Therefore, the concentration of the acids added to the chewing gum was as follows: - Acetic acid at a concentration of 100 mg / ml (or 10% or 10 g / 100 ml), - Citric acid at a concentration of 50 mg / ml (or 5% or 5 g / 100 ml), - Phosphoric acid at a concentration of 1.2 mg / ml (or 0.12% or 0.12 g / 100 ml).

[0050] Toxicity study on human cells The cytotoxicity of the components against human cells was analyzed as follows: THP-1: A human monocytic leukemia cell line obtained from the American Type Culture Collection (ATCC, TIB-202) and cryopreserved in liquid nitrogen. The cells were grown in suspension and maintained in RPMI-1640 medium supplemented with 0.05 mM 2-mercaptoethanol and 10% v / v heat-inactivated fetal bovine serum (Invitrogen). HL60: A human promyelocytic cell line cultured in RPMI medium in suspension supplemented with 10% heat-inactivated FBS. A459: An epithelial cell line derived from human basal alveolar adenocarcinoma in RPMI with 10% heat-inactivated FBS. HepG2: An adherent hepatocytic liver cell line cultured in RPMI supplemented with 10% heat-inactivated FBS.

[0051] In the natural release of cells incubated with LDH (cells incubated with medium) and any composition at the analyzed concentration, no difference was observed up to 120 minutes maximum after exposure, and the composition did not induce toxicity in any of the four cell lines. Here, the composition was composed of the following solution: 10× concentrate - Acetic acid at a concentration of 600 mg / ml (or 60% or 60 g / 100 ml), - Citric acid at a concentration of 2 mg / ml (or 0.2% or 0.2 g / 100 ml), - Phosphoric acid at a concentration of 0.6 mg / ml (or 0.06% or 0.06 g / 100 ml), - RPMI medium (Lonza, BE120-702F). 5× concentrate - Acetic acid at a concentration of 300 mg / ml (or 30% or 30 g / 100 ml), - Citric acid at a concentration of 1 mg / ml (or 0.1% or 0.1 g / 100 ml), - Phosphoric acid at a concentration of 0.3 mg / ml (or 0.03% or 0.03 g / 100 ml), - RPMI medium (Lonza, BE120-702F). 2× concentrate - Acetic acid at a concentration of 120 mg / ml (or 12% or 12 g / 100 ml), - Citric acid at a concentration of 0.4 mg / ml (or 0.04% or 0.04 g / 100 ml), - Phosphoric acid at a concentration of 0.12 mg / ml (or 0.12% or 0.12 g / 100 ml), - RPMI medium (Lonza, BE120 - 702F). 1× concentrated - Acetic acid at a concentration of 60 mg / ml (or 6% or 6 g / 100 ml), - Citric acid at a concentration of 0.2 mg / ml (or 0.02% or 0.02 g / 100 ml), - Phosphoric acid at a concentration of 0.06 mg / ml (or 0.006% or 0.006 g / 100 ml), - RPMI medium (Lonza, BE120 - 702F).

[0052] An acidic solution composed of three of the following acids: acetic acid, citric acid, and phosphoric acid. The compound to be analyzed was prepared by 10 - fold concentration (10×) (2 mg / mL citric acid, 0.6 mg / mL phosphoric acid, and 600 mg / mL acetic acid). The effect of the compound on cell viability was analyzed at four concentrations: 10×, 5×, 2×, and 1×. No cytotoxic effect was observed on the cells analyzed.

[0053] Study related to the risk of acid erosion To select VS8 as an integrated chewing gum composition, three parameters related to the risk of acid erosion and the transient decrease in saliva pH were further measured.

[0054] The transient decrease in the pH of saliva contained in the oral cavity during chewing of the gum was preliminarily established for six volunteers by having them chew chewing gum with a virucidal composition (three volunteers) and a commercially available acid - free chewing gum control (three volunteers), and measuring the pH of the saliva of each volunteer at 0, 2, 4, 8, and 20 minutes after chewing. As shown in the following table, the VS8 solution contained in the chewing gum provides an optimal transient decrease in pH, with a minimum value of about pH 4 at 2 - 4 minutes and complete neutral recovery at 20 minutes. This situation is compatible with the proposed virucidal purpose and dental safety and integrity for the composition.

[0055] [Table 2]

[0056] To select VS8 as a one-piece chewing gum composition, three parameters related to the risk of acid erosion were further measured, and two commonly consumed substances (Pepsi Cola as an example of a carbonated beverage and commercially available lemon juice) were used as a comparison. The parameters were studied at exposure times of 5, 10, and 20 minutes. The enamel layer was mechanically homogenized to a uniform thickness of 0.04 microns on the bovine tooth section for testing. The enamel surface changes caused by the VS8 solution and the solutions used for comparison, commercially available lemon juice (Jif Lemon Juice code: L120302M8) and Pepsi Cola (Pepsi Original Jan 2022 Y06L, 1204), were quantified, and the results were recorded as set below for each of the parameters. (All tests were carried out at Intertek CRS, Unit A4, Elm House, Oaklands Office Park, Hooton, Cheshire CH66 7NZ, Great Britain).

[0057] In the case of the VS8 composition contained in the chewing gum, a 50:50 dilution with artificial saliva was established at 5 and 10 minutes of exposure, and chewing of the chewing gum increased the saliva flow by an average of 4 ml / min, creating conditions similar to the dilution occurring in the mouth.

[0058] The three parameters studied were as follows: 1. Surface microhardness: This parameter indicates the loss of enamel surface hardness as a result of exposure to the compound. The change in this parameter is reversible, and the affected enamel surface can be restored by normal saliva flow. [Table 3]

[0059] 2. Enamel roughness level: This parameter indicates the changes caused by the compound on the surface structure of the tooth surface and measures the smoothness of the tooth surface as a measurement for predicting the potential damage from exposure to the compound.

Table 4

[0060] 3. Enamel erosion: This parameter indicates the actual loss of enamel and is carried out on teeth where the outermost protective layer of dentin has been mechanically removed. The purpose is to directly measure the corrosive ability of the compound on the enamel. A positive result in this test does not imply corrosion in healthy teeth. This is because teeth have a protective layer and the exposed, thus accessible enamel is only an indicator of the potential of the compound to attack the enamel.

Table 5

[0061] The results obtained by measuring these parameters for VS8 with an exposure time of up to 20 minutes in accordance with the dilution guidelines corresponding to chewing chewing gum in the mouth are as follows: The softening of the surface microhardness of the tooth, the change in enamel roughness, and enamel erosion are within the safety margin, and statistical verification approached the effects caused by commonly consumed carbonated beverages (Pepsi Cola) and was significantly lower than the effects caused by commercially available lemon juice.

Claims

1. 1 to 30% w / v acetic acid, 0.2 to 10% w / v citric acid, 0.01 to 1.0% w / v phosphoric acid A chewing gum containing, wherein said % w / v relates to the weight of the total volume of said composition, chewing gum.

2. acetic acid is contained in an amount of 2 to 3% w / v, preferably 2.5%, citric acid is contained in an amount of 1.5 to 2% w / v, preferably 1.75%, and phosphoric acid is contained in an amount of 0.05 to 0.07% w / v, preferably 0.06%, the chewing gum according to claim 1.

3. The chewing gum base is - an elastomeric polymer, preferably a specially purified elastomeric polymer, - a resin, - a purified wax, - a plant fatty acid glycerol ester, - a fully hardened vegetable oil, - talc, - a maximum amount of 0.1% antioxidant, preferably TCPHN The chewing gum according to claim 2, comprising.

4. The chewing gum according to any one of the preceding claims, comprising a base gum and at least one or more components selected from the group of sweeteners, flavoring agents, taste-masking agents and vitamins.

5. A set of chewing gum and wrapping paper, wherein the chewing gum is described in any one of the preceding claims and the wrapping paper is a filter paper that comes into direct contact with the chewing gum.

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