Fluorescent silica nanoparticles and method for producing the same

Fluorescent silica nanoparticles with a core-shell structure, comprising silica-encapsulated gold nanoparticles and silica-encapsulated rare-earth complexes, address the issue of shortened fluorescence lifetime at high concentrations by enhancing the fluorescence lifetime by 1.5 times.

JP2026086262APending Publication Date: 2026-05-26TOSOH CORP +1

Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
TOSOH CORP
Filing Date
2024-11-14
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing fluorescent nanoparticles, particularly those encapsulating rare earth fluorescent complexes, suffer from significantly shortened fluorescence lifetime when used at high concentrations.

Method used

The development of fluorescent silica nanoparticles with a core-shell structure, where the core is composed of silica-encapsulated gold nanoparticles and the shell is composed of silica-encapsulated rare-earth fluorescent complexes, effectively prolongs the fluorescence lifetime even at high concentrations of rare-earth fluorescent complexes.

Benefits of technology

The core-shell structure enables a fluorescence lifetime that is 1.5 times longer than comparative nanoparticles without gold nanoparticles, maintaining fluorescence intensity despite high concentrations of rare-earth complexes.

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Abstract

The present invention provides fluorescent nanoparticles with a long fluorescence lifetime and a method for producing the same. [Solution] The fluorescent silica nanoparticles of the present invention comprise silica, and rare earth fluorescent complexes and gold nanoparticles encapsulated within the silica. Furthermore, the method of the present invention for producing fluorescent silica nanoparticles includes providing gold nanoparticle-encapsulated silica nanoparticles containing gold nanoparticles, and coating the gold nanoparticle-encapsulated silica nanoparticles with silica containing a rare earth fluorescent complex.
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