Microneedle patch structure

Abstract

This invention provides a microneedle patch structure to which astaxanthin has been added. [Solution] The invention comprises a base material 110 and a microneedle layer 120, the base material having a first surface. The microneedle layer is provided on the first surface of the base material and includes a bottom layer 121 and a plurality of microneedle units 122. The bottom layer is fixed to the first surface of the base material. The plurality of microneedle units are integrally connected to the bottom layer, and the microneedle units are provided separately from each other on surfaces different from the first surface of the bottom layer. The microneedle layer further includes a plurality of astaxanthin particles 123 uniformly distributed within the microneedle layer. The astaxanthin particles are injected into the skin tissue layer by layer as the microneedle units puncture the skin surface, allowing the astaxanthin particles to exert their antioxidant and anti-inflammatory effects.

Description

Technical Field

[0001] The present invention relates to a micro needle patch structure, and particularly to a micro needle patch structure added with astaxanthin.

Background Art

[0002] With the progress of medicine and the prevalence of the beauty industry, how to quickly transmit drugs or active ingredients to the human body on the premise of safety and effectiveness to achieve the corresponding medical or beauty effects has become the direction that the related industry, academia and business community are working hard on.

[0003] In order to achieve the above object, manufacturers add drugs or other active ingredients to the micro needle patch, and puncture the skin surface with the needle tip of the micro needle patch, so that the drugs or active ingredients are absorbed from the tiny wounds on the skin and enter the blood circulation, thereby achieving the purpose of administration. Administration using a micro needle patch can not only solve the problem that drugs are destroyed in the gastrointestinal tract during conventional oral administration, but also prevent the pain and infection risk associated with subcutaneous injection. At the same time, it has advantages such as convenient administration and good patient compliance.

Summary of the Invention

Problems to be Solved by the Invention

[0004] Astaxanthin (also called astaxanthin, phycoerythrin, canthaxanthin, alloxanthin or astacin) is a natural carotenoid with excellent antioxidant and anti-inflammatory effects, and is widely applied to skin pharmaceuticals and health foods. Therefore, if astaxanthin is applied to a micro needle patch and administered by sticking it to the skin, it is possible to ensure the absorption of astaxanthin by the human body and greatly expand the application range of astaxanthin.

Means for Solving the Problems

[0005] One embodiment of the present invention provides a microneedle patch structure comprising a substrate and a microneedle layer. The substrate has a first surface. The microneedle layer is provided on the first surface of the substrate and includes a bottom layer and a plurality of microneedle units. The bottom layer is fixed to the first surface of the substrate. The plurality of microneedle units are integrally connected to the bottom layer, and the microneedle units are provided separately from each other on surfaces different from the first surface of the bottom layer. The microneedle layer further comprises a plurality of astaxanthin particles uniformly distributed within the microneedle layer.

[0006] According to the microneedle patch structure of the above embodiment, each of the astaxanthin particles may be free astaxanthin.

[0007] According to the microneedle patch structure of the above embodiment, the microneedle layer may be formed by a microneedle composition, and the microneedle composition may contain the astaxanthin particles and the active material.

[0008] According to the microneedle patch structure of the above embodiment, the active material may include hyaluronic acid, glucosamine, polyglutamic acid, collagen, exosomes, and maca.

[0009] According to the microneedle patch structure of the above embodiment, the weight percentage of the astaxanthin particles in the microneedle composition may be 0.0005% to 0.01%.

[0010] According to the microneedle patch structure of the above embodiment, the thickness of the bottom layer may be 0.01 mm to 0.5 mm.

[0011] According to the microneedle patch structure of the above embodiment, the density on the surface of the bottom layer of the microneedle unit is 10 needles / cm 2 ~10000 stitches / cm 2 That's fine.

[0012] According to the microneedle patch structure of the above embodiment, the shape of each of the microneedle units may be pyramidal, conical, pointed, or a combination thereof.

[0013] According to the microneedle patch structure of the above embodiment, the material of the substrate may be polypropylene, polyethylene terephthalate, polyurethane, silicone, or a combination thereof.

[0014] As a result, the microneedle patch structure of this invention has advantages such as rapid administration, minimal contamination, painlessness, and low risk of infection. Furthermore, the antioxidant and anti-inflammatory effects of the astaxanthin particles can be effectively exerted, and it has potential applications in related industries. [Brief explanation of the drawing]

[0015] To make the above and other purposes, features, advantages, and embodiments of this invention clearer and easier to understand, the accompanying drawings are described below. [Figure 1] This is a schematic diagram showing a microneedle patch structure in one embodiment of the present invention. [Figure 2] This is a cross-sectional view of the microneedle patch structure in Figure 1, along the cross-sectional line 2-2. [Figure 3] Figure 1 is a schematic diagram showing the microneedle unit of the microneedle patch structure. [Modes for carrying out the invention]

[0016] The embodiments of this invention will be described in more detail below. However, these embodiments may be applications of various inventive concepts and may be specifically implemented in various different specific scopes. Specific embodiments are for illustrative purposes only and are not limited to the disclosed scope. Also, in order to simplify the drawings, certain conventional structures and elements are shown simply and schematically in the drawings, and overlapping elements may be indicated by the same number.

[0017] Please refer to Figures 1, 2, and 3. Figure 1 is a schematic diagram showing a microneedle patch structure 100 in one embodiment of the present invention, Figure 2 is a cross-sectional view of the microneedle patch structure 100 of Figure 1 along cross-sectional line 2-2, and Figure 3 is a schematic diagram showing a microneedle unit 122 of the microneedle patch structure 100 of Figure 1. The microneedle patch structure 100 includes a substrate 110 and a microneedle layer 120.

[0018] The base material 110 has a first surface 111. More specifically, the base material 110 is the part of the microneedle patch structure 100 that is attached and fixed to the user's skin. When using the microneedle patch structure 100 of the present invention, the base material 110 can be attached to the user's skin with its first surface 111 facing the user's skin. The material of the base material 110 may be polypropylene (PP), polyethylene terephthalate (PET), polyurethane (PU), silicone, or a combination thereof. Alternatively, a skin-friendly material such as a bandage, tape, or patch may be selected, thereby satisfying different requirements such as waterproofing, breathability, antibacterial properties, and deodorizing properties. However, the present invention is not limited to these.

[0019] The microneedle layer 120 is provided on the first surface 111 of the substrate 110 and includes a bottom layer 121 and a plurality of microneedle units 122. The bottom layer 121 is fixed to the first surface 111 of the substrate 110, the plurality of microneedle units 122 are integrally connected to the bottom layer 121, and the plurality of microneedle units 122 are provided separately from each other on a surface (not shown) of the bottom layer 121 that is different from the first surface 111.

[0020] As shown in Figures 1 and 2, the multiple microneedle units 122 are uniformly distributed in the bottom layer 121, and the spacing between the microneedle units 122 is approximately equal. In this way, the multiple microneedle units 122 are uniformly inserted into the user's skin, and the active ingredients within them can be released. Alternatively, the density of microneedle units 122 on the surface of the bottom layer 121 is 10 needles / cm 2 ~10000 stitches / cm 2 The spacing between any two microneedle units 122 may be 0.5 mm to 5 mm. Preferably, the density on the surface of the bottom layer 121 of the microneedle units 122 is 70 needles / cm 2 ~120 stitches / cm 2 This may be the case, but the present invention is not limited thereto.

[0021] In addition to the irregular shape shown in FIG. 1, the shape of the base material 110 can also be adjusted to a circular shape, a square shape, a triangular shape, a fan shape, etc. according to the application site. Moreover, an adhesive material can be applied to the first surface 111 to enhance the stability when the base material 110 is attached to the skin, but the present invention is not limited thereto. Note that the area of the base material 110 can be made larger than the area of the microneedle layer 120. When the microneedle patch structure 100 of the present invention is used, the portion of the first surface 111 of the base material 110 that is not connected to the microneedle layer 120 can directly contact the skin of the user. At this time, due to the adhesiveness of the base material 110, the microneedle patch structure 100 can be fixed to the skin of the user, preventing the displacement or detachment of the microneedle patch structure 100, effectively pressing the microneedle layer 120 to pierce the microneedle unit 122 into the skin, and further effectively releasing the active ingredient therein. Also, the thickness of the base material 110 can be adjusted as needed and can be arranged in the range of 0.1 cm to 1 cm, but the present invention is not limited thereto either.

[0022] Furthermore, as shown in FIGS. 2 and 3, the shape of the microneedle unit 122 of the microneedle patch structure 100 of the present invention may be a pyramid shape as shown in FIG. 3, may be a conical shape or a spire shape as needed, and the microneedle patch structure 100 may simultaneously include microneedle units 122 in different forms, but the present invention is not limited thereto. Note that the thickness of the bottom layer 121 may be in the range of 0.01 mm to 0.5 mm, the length of each microneedle unit 122 may be in the range of 0.05 mm to 2.0 mm, and the width of the microneedle unit 122 may be in the range of 0.01 mm to 1.0 mm, but the present invention is not limited thereto either. Preferably, the length of each microneedle unit 122 may be less than 300 nm, but the present invention is not limited thereto either.

[0023] In the micro-needle patch structure 100 of the present invention, the micro-needle layer 120 further includes a plurality of astaxanthin particles 123, and the astaxanthin particles 123 are uniformly distributed in the micro-needle layer 120. Specifically, the astaxanthin particles 123 are uniformly distributed in the bottom layer 121 and the micro-needle units 122 of the micro-needle layer 120. When the micro-needle patch structure 100 of the present invention is used, the micro-needle units 122 are pierced into the skin of the user. At this time, the astaxanthin particles 123 are injected into the skin tissue layer by layer simultaneously when the micro-needle units 122 pierce the skin surface. By quickly entering the human body, the astaxanthin particles 123 can achieve antioxidant and anti-inflammatory effects.

[0024] Each of the astaxanthin particles 123 may be free-form astaxanthin. Specifically, most of the astaxanthin extracted from algae is ester-form astaxanthin. However, ester-form astaxanthin has a fatty acid structure in its structure, a large molecular weight, and can be absorbed and utilized only after hydrolysis digestion by enzymes in the living body. Since the micro-needle patch structure 100 of the present invention is administered by subcutaneous injection, if ester-form astaxanthin is directly applied to the micro-needle patch structure 100 of the present invention, the chemical structure of ester-form astaxanthin cannot be effectively converted, and its absorption effect may not be as expected. Therefore, the astaxanthin particles 123 used in the micro-needle patch structure 100 of the present invention are selected as free-form astaxanthin. Free-form astaxanthin is obtained by removing the fatty acid structure from ester-form astaxanthin, has a small molecular weight, and can be absorbed and utilized from the skin without passing through the human digestive tract. Thereby, the micro-needle patch structure 100 of the present invention can more effectively exert the antioxidant and anti-inflammatory effects of the astaxanthin particles 123 and has application potential in related industries.

[0025] In the microneedle patch structure 100 of this invention, the microneedle layer 120 may be formed from a microneedle composition (not shown), and the microneedle composition may contain a plurality of astaxanthin particles 123 and an active material. Specifically, when manufacturing the microneedle patch structure 100 of this invention, the microneedle composition is injected into a microneedle model corresponding to the appearance of the microneedle layer 120, and after processes such as drying, a microneedle layer 120 containing a bottom layer 121 and a plurality of microneedle units 122 is formed. In this way, the astaxanthin particles 123 and the active material can be uniformly mixed in the microneedle composition beforehand, and as a result, the manufactured microneedle layer 120 contains uniformly distributed astaxanthin particles 123 and the active material, allowing the microneedle patch structure 100 of this invention to release its active ingredients more uniformly when used. The active material may include hyaluronic acid, glucosamine, polyglutamic acid, collagen, exosomes, and maca.

[0026] Hyaluronic acid (HA), also known as clear acid, is widely present in the cartilage tissue, bodily fluids, and epidermal tissue of the human body and has excellent water-retaining properties. Therefore, it is often used as a moisturizing product in pharmaceuticals to achieve effects such as skin hydration and wrinkle reduction. Accordingly, when the microneedle layer 120 of the microneedle patch structure 100 of this invention is manufactured by a microneedle composition containing astaxanthin particles 123 and hyaluronic acid, the microneedle patch structure 100 can be further applied to the user's face, neck, or other more delicate areas. In this case, the hyaluronic acid dissolves and is released rapidly after the microneedle unit 122 penetrates the user's skin, entering the user's skin tissue together with the astaxanthin particles 123. This not only provides a rapid moisturizing effect on the skin, but also, combined with the anti-inflammatory and antioxidant effects of the astaxanthin particles 123, can achieve the goal of smoothing and reducing wrinkles.

[0027] Glucosamine is an amino acid monosaccharide found in human tissues, and is one of the main components of cartilage matrix and synovial fluid, having the effect of lubricating joints and reducing friction between bones. Therefore, when the microneedle layer 120 of the microneedle patch structure 100 of this invention is manufactured using a microneedle composition containing astaxanthin particles 123 and glucosamine, the microneedle patch structure 100 can be further applied to areas corresponding to joints such as the user's legs and waist. At this time, the glucosamine is rapidly released after the microneedle unit 122 penetrates the user's skin and enters the joint, and together with the anti-inflammatory and antioxidant effects of astaxanthin particles 123, it can alleviate the symptoms of osteoarthritis.

[0028] Polyglutamic acid (γ-PGA) is a polymer of amino acids and a biodegradable natural polymer. Polyglutamic acid has extremely excellent moisturizing properties and can increase skin elasticity and the content of natural moisturizing factors in the skin with continuous use. Therefore, when the microneedle layer 120 of the microneedle patch structure 100 of this invention is manufactured by a microneedle composition containing astaxanthin particles 123 and polyglutamic acid, the microneedle patch structure 100 can be further applied to the user's face, neck, or other more delicate areas. In this case, the polyglutamic acid dissolves and is released rapidly after the microneedle unit 122 penetrates the user's skin, entering the user's skin tissue together with the astaxanthin particles 123. This not only provides a rapid moisturizing effect on the skin, but also, combined with the anti-inflammatory and antioxidant effects of the astaxanthin particles 123, can achieve the goal of smoothing and reducing wrinkles.

[0029] Collagen is a major structural protein component of the extracellular matrix and connective tissue of animals and can maintain skin elasticity. Therefore, if the microneedle layer 120 of the microneedle patch structure 100 of this invention is manufactured by a microneedle composition containing astaxanthin particles 123 and collagen, the microneedle patch structure 100 can be further applied to the user's face, neck, or other more delicate areas. In this case, the collagen enters the user's skin tissue together with the astaxanthin particles 123 after the microneedle unit 122 has penetrated the user's skin, thereby not only providing sufficient elasticity and moisture to the skin, but also achieving the purpose of smoothing and reducing wrinkles by combining with the anti-inflammatory and antioxidant effects of the astaxanthin particles 123.

[0030] Exosomes are membranous vesicles released into the extracellular matrix after the fusion of the polyendoplasmic reticulum and plasma membrane within a cell, or directly through the plasma membrane. They contain substances such as DNA, mRNA, and proteins, and play an important role in cellular signal transduction. In the field of cosmetic medicine, the substances within exosomes can help repair damaged tissue, restore skin elasticity, promote fibroblast activation, and aid in collagen production. Therefore, if the microneedle layer 120 of the microneedle patch structure 100 of this invention is manufactured by a microneedle composition containing astaxanthin particles 123 and exosomes, the microneedle patch structure 100 can be further applied to the user's face, neck, or other more delicate areas. In this case, the exosomes release their active substances when the microneedle units 122 penetrate the user's skin, and combined with the anti-inflammatory and antioxidant effects of the astaxanthin particles 123, the goal of smoothing and reducing wrinkles can be achieved.

[0031] Maca is an extract of Peruvian ginseng (Lepidium peruvianum) and contains abundant nutrients that improve the vitality of the human body and help regulate hormones, so it is widely used in the health food field for the purpose of enhancing male virility. Therefore, if the microneedle layer 120 of the microneedle patch structure 100 of this invention is manufactured by a microneedle composition containing astaxanthin particles 123 and maca, the microneedle patch structure 100 can be further applied to the user's lower abdomen. At this time, the maca and astaxanthin particles 123 are rapidly released after the microneedle unit 122 penetrates the user's skin, thereby allowing the human body to quickly absorb the nutrients of maca and achieve effects such as improved vitality and hormone regulation.

[0032] The microneedle composition may further contain whitening ingredients, moisturizing ingredients, antioxidants, anti-wrinkle ingredients, or combinations thereof. For example, the whitening ingredients may be kojic acid, arbutin, sodium ascorbyl phosphate, magnesium ascorbyl phosphate, ascorbyl glycoside, ellagic acid, chamomile extract, cetyltranexamate HCl, potassium 4-methoxysalicylate, 3-O-ethyl ascorbic acid, or nonapeptide. The moisturizing ingredients may be ceramide, lecithin, glycerol, polysaccharides, protein, elastin, peptide, amino acid, citrate, uric acid, urea, glucose, sucrose, fructose, glycogen, glucosamine, mucopolysaccharides, lactate, phosphate, or ethyl-dl-2-pyrrolidone-5-carboxylate.The antioxidants may be grape extract, green tea extract, ginkgo extract, soy extract, pomegranate extract, ginger extract, yeast extract, coix extract, R-alpha-lipoic acid, glucan, coenzyme Q10, superoxide dismutase (SOD), vitamin C and its derivatives, or vitamin E and its derivatives. The anti-wrinkle components may be vitamin A (retinol) and its derivatives, copper peptide (GHK-Cu), pentapeptide, or hexapeptide.

[0033] In addition, the microneedle composition may further contain other types of polymer materials, and the selection of polymer materials can be adjusted according to the needs of cosmetic medicine, the site of use, and the target of use. For example, the polymer material may be polylactic acid (PLA), which promotes skin regeneration and repair, improves skin texture, and has a scar-fading effect. The polymer material may be polyvinyl alcohol (PVA), which improves the adhesion between the microneedle layer 120 and the skin. The polymer material may be polylactic acid-glycolic acid (PLGA), which promotes drug release from the microneedle layer 120. The polymer material may be polyvinyl alcohol-sodium polyacrylate copolymer (PVP / PA), which improves the adhesion between the microneedle layer 120 and the skin. Alternatively, the polymer material may be polycaprolactone (PCL), which promotes skin tissue regeneration and repair, and has a skin-filling and tightening effect. However, the present invention is not limited to the above components.

[0034] The microneedle composition may further contain an antibacterial agent, which may be p-hydroxyacetophenone, pentylene glycol, hexanediol, caprylyl glycol, phenoxyethanol, benzyl alcohol, salicylic acid, benzoic acid, sorbic acid, potassium sorbate, propionic acid, dehydroacetic acid, chlorophenesin, behentrimonium chloride, benzalkonium chloride, benzethonium chloride, butyl benzoate, or dimethyloxazolidine. oxazolidine), bromochlorophene, dichlorobenzyl alcohol, ethyl lauroyl arginate HCl, 7-ethylbicyclooxazolidine, formic acid, glutaral, hexamidine, sodium sulfite, iodopropynyl butylcarbamate, methylisothiazolinone, butylparaben, methylparaben, phenoxyisopropanol, phenylmercury acetateAcetate, triclocarban, undecylenic acid, zinc pyrithione, 5-bromo-5-nitro-1,3-dioxane, benzylhemiformal, DMDM ​​Hydantoin, diazolidinyl urea, imidazolidinyl urea, methenamine, quaternium-15, sodium hydroxymethylglycinate, Leuconostoc sp., Lactobacillus ferment, Populus Tremuloides Bark Extract The present invention may include, but is not limited to, extracts, blackcurrant fruit extract, or a combination thereof.

[0035] Furthermore, the weight percentage of astaxanthin particles 123 in the microneedle composition may be 0.0005% to 0.01%. Specifically, when the weight percentage of astaxanthin particles 123 in the microneedle composition is 0.0005% to 0.01%, the concentration of astaxanthin particles 123 is appropriate, thereby enabling the manufactured microneedle layer 120 to effectively release the astaxanthin particles 123, preventing the release from being inhibited due to an excessively high concentration of astaxanthin particles 123, or failing to achieve the corresponding effect due to an excessively low concentration of astaxanthin particles 123.

[0036] In summary, the advantages of the microneedle patch structure of this invention are as follows: Firstly, the microneedle patch structure of this invention contains astaxanthin particles, a natural ingredient, in the microneedle layer, and the astaxanthin particles are uniformly distributed within the microneedle layer. Therefore, when using the microneedle patch structure of this invention, the astaxanthin particles are injected into the skin tissue layer by layer as the microneedle units puncture the skin surface. As a result, the microneedle patch structure of this invention has advantages such as rapid administration, less contamination, no pain, and low risk of infection, as well as the ability to effectively exert the antioxidant and anti-inflammatory effects of astaxanthin particles, and has potential for application in related industries. Secondly, by selecting free astaxanthin as the astaxanthin particles, the astaxanthin particles are directly absorbed and utilized by the skin. Therefore, the microneedle patch structure of this invention can more effectively exert the antioxidant and anti-inflammatory effects of astaxanthin particles. Thirdly, since the microneedle layer is formed by the microneedle composition, the astaxanthin particles and active materials can be uniformly mixed in the microneedle composition beforehand. As a result, the manufactured microneedle layer contains uniformly distributed astaxanthin particles and active materials, allowing for more uniform release of the active ingredients during use and achieving the corresponding effect.

[0037] Although the present invention has been disclosed in the embodiments described above, these embodiments are not intended to limit the present invention. Those skilled in the art can make various changes and modifications without departing from the spirit and scope of the present invention; therefore, the scope of protection of the present invention should be based on the scope defined by the attached utility model claims. [Explanation of Symbols]

[0038] 100: Microneedle patch structure 110: Base material 111: 1st surface 120: Microneedle layer 121: Bottom layer 122: Microneedle Unit 123: Astaxanthin particles 2-2: Section line

Claims

1. It has a microneedle patch structure, A substrate having a first surface, The substrate includes a bottom layer fixed to the first surface of the substrate, and a plurality of microneedle units integrally connected to the bottom layer and provided on a surface different from the first surface of the bottom layer, separated from each other. Includes, The microneedle layer is a microneedle patch structure further comprising a plurality of astaxanthin particles uniformly distributed in the microneedle layer.

2. The microneedle patch structure according to claim 1, wherein each of the plurality of astaxanthin particles is free astaxanthin.

3. The microneedle patch structure according to claim 1, wherein the microneedle layer is formed by a microneedle composition comprising the plurality of astaxanthin particles and an active material.

4. The microneedle patch structure according to claim 3, wherein the active material comprises hyaluronic acid, glucosamine, polyglutamic acid, collagen, exosomes, and maca.

5. The microneedle patch structure according to claim 3, wherein the weight percentage of the plurality of astaxanthin particles in the microneedle composition is 0.0005% to 0.01%.

6. The microneedle patch structure according to claim 1, wherein the thickness of the bottom layer is 0.01 mm to 0.5 mm.

7. The density on the surface of the bottom layer of the plurality of microneedle units is 10 needles / cm ２ ~10000 stitches / cm ２ The microneedle patch structure according to claim 1.

8. The microneedle patch structure according to claim 1, wherein the shape of each of the plurality of microneedle units is pyramidal, conical, pointed, or a combination thereof.

9. The microneedle patch structure according to claim 1, wherein the material of the substrate is polypropylene, polyethylene terephthalate, polyurethane, silicone, or a combination thereof.

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