Hair treatment composition and hair treatment method

Abstract

To provide a hair treatment agent composition containing cystine in which deterioration over time is suppressed.SOLUTION: A hair treatment agent composition in which a second agent is applied to hair after a first agent is applied to hair, in which the first agent has a first composition which contains cystine and substantially does not contain water, and a second composition containing water. In the first agent, the first composition and the second composition are mixed and applied to hair as the first agent when using the first agent, and pH of the first agent is 8.5 to 12.5, and pH of the second agent is 2 to 5.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a hair treatment composition and a hair treatment method. [Background technology]

[0002] Hair is easily damaged by chemical treatments such as oxidative hair dyes and perms, and by heat treatments such as with hair dryers. For this reason, the development of hair treatments aimed at improving the feel of hair (e.g., hair firmness, resilience, etc.) has been studied. Patent Document 1 discloses a hair treatment composition having a first agent containing cystine and an alkaline agent and a second agent containing an organic acid. It has been shown that this hair treatment composition repairs damage to hair by applying the first agent to the hair and then applying the second agent to the hair. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Patent No. 6052863 Summary of the Invention [Problem to be solved by the invention]

[0004] Hair treatment compositions containing cystine have problems in that, over time after dissolving cystine in an alkaline solvent, the amount of cystine in the hair treatment composition decreases, resulting in a decrease in the repair effect, and the hair treatment composition begins to smell or discolor due to deterioration over time.

[0005] An object of the present invention is to provide a hair treatment composition containing cystine, which is inhibited from deteriorating over time. [Means for solving the problem]

[0006] [1] A hair treatment composition comprising a first agent containing cystine applied to hair, and a second agent having a pH of 2 to 5 applied to hair, The first agent comprises a solid cystine-containing composition that contains solid cystine and is substantially free of water, or a hydrous cystine-containing composition that contains cystine and water and has a pH of 8.0 or less, 1. A hair treatment composition, wherein the first agent has a pH of 8.5 to 12.5 when applied to hair. According to this hair treatment composition, the first agent is distributed as a solid cystine-containing composition that contains solid cystine and is substantially free of water, or as a hydrous cystine-containing composition that contains cystine and water and has a pH of 8.0 or less, and dissolves cystine in an alkaline solvent when applied to hair, thereby making it possible to suppress deterioration over time that occurs when cystine is dissolved in an alkaline solvent. [2] The hair treatment composition according to [1], wherein the first agent is the solid cystine-containing composition, and the solid cystine-containing composition contains an inorganic salt that exhibits alkalinity when dissolved in water. Since the solid cystine-containing composition contains an inorganic salt that exhibits alkalinity when dissolved in water, it is possible to incorporate an alkaline agent into the solid cystine-containing composition, which allows raw materials that are weak against alkali to be added to the liquid formulation. [3] The hair treatment composition according to [2], wherein the ratio of the cystine content to the inorganic salt content in the first agent (cystine / inorganic salt) is 0.025 to 5. By adjusting the ratio of the cystine content to the inorganic salt content (cystine / inorganic salt) to 0.025 to 5, a balance between the hair repair effect and elasticity can be achieved, and the effects of the present invention can be further exerted. [4] The hair treatment composition according to any one of [1] to [3], wherein the first agent contains at least one type selected from oligosaccharides. The inclusion of oligosaccharides has the effect of improving the elasticity of hair. [5] A hair treatment method using a hair treatment composition, comprising applying a first agent containing cystine to hair, and then applying a second agent having a pH of 2 to 5 to the hair, A solid cystine-containing composition containing solid cystine and substantially no water, or a hydrous cystine-containing composition containing cystine and water and having a pH of 8.0 or less, A hair treatment method, characterized in that the first agent has a pH of 8.5 to 12.5 when applied to hair. According to this hair treatment method, the first agent is distributed as a solid cystine-containing composition that contains solid cystine and is substantially free of water, or as a hydrous cystine-containing composition that contains cystine and water and has a pH of 8.0 or less, and dissolves cystine in an alkaline solvent when applied to hair, thereby making it possible to suppress deterioration over time that occurs when cystine is dissolved in an alkaline solvent. Effect of the Invention

[0007] Effects of the Invention According to the present invention, it is possible to provide a hair treatment composition containing cystine, in which deterioration over time is suppressed. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0008] The hair treatment composition of the present invention and a hair treatment method using the hair treatment composition are described below. The hair treatment composition of the present invention is a hair treatment composition having a first agent and a second agent. The first agent and the second agent are distributed as separate agents, and the first agent has a solid cystine-containing composition that contains solid cystine and is substantially free of water, or a hydrous cystine-containing composition that contains cystine and water and has a pH of 8.0 or less.

[0009] [About the first drug] The first agent comprises a solid cystine-containing composition that contains solid cystine and is substantially free of water, or a hydrous cystine-containing composition that contains cystine and water and has a pH of 8.0 or less. The solid cystine-containing composition or the hydrous cystine-containing composition does not dissolve cystine in an alkaline solvent, so that deterioration over time that occurs when cystine is dissolved in an alkaline solvent can be suppressed. In addition, when applied to hair, the pH of the first agent is adjusted to 8.5 to 12.5, so that the repair feeling and elasticity of the hair can be improved. Note that application to hair refers to the act of applying the first agent or the second agent to hair.

[0010] The pH of the first agent in the hair treatment composition of the present invention is 8.5 to 12.5. If the pH is less than 8.5, there is a risk that cystine cannot be sufficiently dissolved. On the other hand, if the pH is more than 12.5, there is a risk that the hair may be damaged and breakage may occur. The lower limit of the pH of the first agent is preferably 9.0 or more, more preferably 9.5 or more. The upper limit of the pH of the first agent is preferably 12.0 or less, more preferably 11.5 or less. The pH of the first agent is measured at 25° C. when the first agent is dissolved in water at a concentration of 10% by mass.

[0011] The first agent requires a separate composition for preparing a cystine solution having a pH of 8.5 to 12.5 in addition to a solid cystine-containing composition or a hydrous cystine-containing composition. When a solid cystine-containing composition is used, a separate composition containing water for dissolving solid cystine is required. When a hydrous cystine-containing composition is used, a separate composition containing an alkaline agent is required.

[0012] (Solid cystine-containing composition) The solid cystine-containing composition is a composition that contains solid cystine and is substantially free of water, and constitutes the first agent. In the following, the solid cystine-containing composition will be referred to as the first composition, and the composition that contains water will be referred to as the second composition.

[0013] In the present invention, "substantially free of water" means "water is not separately contained" and does not exclude the incorporation of a small amount of water contained in each compounded component. More specifically, for example, the loss on drying test method (1 g, 105°C, 4 hours) of the Japanese Pharmacopoeia is preferably 5% or less, more preferably 3% or less.

[0014] The dosage form of the first composition is not particularly limited as long as it is a dosage form that does not substantially contain water. For example, powder, granule, tablet, tablet, etc. are mentioned. From the viewpoint of excellent solubility, powder and granule are preferable. From the viewpoint of excellent handling during mixing with the second composition, tablet and tablet are preferable.

[0015] The dosage form of the second composition is not particularly limited as long as it is a dosage form containing water. For example, liquid, gel, cream, foam, etc. are included. From the viewpoint of easy dissolution of the first composition, liquid and gel are particularly preferable.

[0016] In the hair treatment composition of the present invention, unless cystine is dissolved in the alkaline solvent, deterioration of the first agent over time does not occur, and therefore the alkaline agent may be blended as a solid into the first composition, may be dissolved in the second composition, or may be a separate agent from the first and second compositions. For example, the first composition containing cystine, the second composition containing water, and the third composition containing the alkaline agent may be distributed separately, and the first composition, the second composition, and the third composition may be mixed together to prepare the first agent when the first agent is used.

[0017] From the viewpoint of simplifying the mixing operation, the alkaline agent is preferably blended into the first composition or the second composition. When blending the alkaline agent into the first composition, the alkaline agent may be added as a solid. When blending the alkaline agent into the second composition, the state of the alkaline agent is not particularly limited, and may be a solid or liquid. From the viewpoint of excellent handling, it is more preferable to blend a solid alkaline agent into the first composition.

[0018] In addition, the second composition containing water in the present invention is not limited to that distributed by the manufacturer of the first composition, but also includes cases where a person using the first agent prepares water from a tap and uses it.

[0019] (Hydrated cystine-containing composition) The hydrous cystine-containing composition contains cystine and water, has a pH of 8.0 or less, and constitutes the first agent. When using the hydrous cystine-containing composition, a separate composition containing an alkaline agent for adjusting the pH of the first agent to 8.5 to 12.5 is required.

[0020] The dosage form of the hydrous cystine-containing composition is not particularly limited as long as it contains water, and examples thereof include liquids, gels, creams, and foams.

[0021] In addition, in the composition containing an alkaline agent, the state of the alkaline agent is not particularly limited, and examples thereof include liquid preparations such as solutions, gels, creams, and foams, and solid preparations such as powders, granules, tablets, and tablets.

[0022] [Ingredients to be mixed into the first agent] (Cystine) The first agent contains cystine. The content of cystine in the first agent is not particularly limited, but is, for example, 0.001 to 30% by mass. The lower limit of the content of cystine is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, even more preferably 0.1% by mass or more, and particularly preferably 0.3% by mass or more. The upper limit of the content of cystine is preferably 20% by mass or less, more preferably 10% by mass or less, even more preferably 5% by mass or less, and particularly preferably 3% by mass or less. By setting the content of cystine to 0.001 to 30% by mass, the effect of the present invention can be further exhibited.

[0023] (Alkaline agent) The first agent contains an alkaline agent. The alkaline agent is not particularly limited as long as it dissolves in water and exhibits alkalinity. For example, examples of the alkaline agent include inorganic alkaline agents such as carbonates, hydrogen carbonates, inorganic ammonium salts, silicates, metasilicates, phosphates, hydroxides, and their salts, and organic alkaline agents such as ammonia, alkanolamines, basic amino acids, and organic ammonium salts. The alkaline agents may be blended alone or in combination of two or more.

[0024] Specific examples of carbonates include sodium carbonate, potassium carbonate, ammonium carbonate, calcium carbonate, magnesium carbonate, and guanidine carbonate. Specific examples of hydrogen carbonates include sodium hydrogen carbonate, potassium hydrogen carbonate, and ammonium hydrogen carbonate. Specific examples of inorganic ammonium salts include ammonium carbonate, ammonium hydrogen carbonate, ammonium phosphate, and ammonium hydrogen phosphate. Specific examples of silicates include sodium silicate and potassium silicate. Specific examples of metasilicates include sodium metasilicate and potassium metasilicate. Specific examples of phosphates include diammonium phosphate, disodium phosphate, and trisodium phosphate. Specific examples of hydroxides include calcium hydroxide, magnesium hydroxide, sodium hydroxide, and potassium hydroxide.

[0025] Specific examples of alkanolamines include monoethanolamine, diethanolamine, triethanolamine, monopropanolamine, isopropanolamine, dipropanolamine, tripropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol, and 2-amino-2-hydroxymethyl-1,3-propanediol. Specific examples of basic amino acids include arginine, lysine, and salts thereof. Specific examples of organic ammonium salts include organic ammonium salts such as ammonium lactate, ammonium citrate, and ammonium glycolate.

[0026] The content of the alkaline agent in the first agent is not particularly limited as long as it can exert the intended function of the alkaline agent. For example, the content of the alkaline agent in the first agent is preferably 0.01% by mass or more and 40.0% by mass or less. The lower limit of the content of the alkaline agent is more preferably 0.05% by mass or more, even more preferably 0.1% by mass or more, and particularly preferably 0.2% by mass or more. On the other hand, the upper limit of the content of the alkaline agent is more preferably 30.0% by mass or less, even more preferably 20.0% by mass or less, and particularly preferably 10.0% by mass or less.

[0027] As the alkaline agent, an inorganic salt that exhibits alkalinity when dissolved in water (a salt of an inorganic alkaline agent that is solid at 25°C and dissolves in water. Hereinafter, it may be simply referred to as "inorganic salt") is suitable. When an inorganic salt that exhibits alkalinity when dissolved in water is used, the alkaline agent can be blended as a solid, and therefore can be blended in the first composition. From the viewpoints of solubility in water, strong alkalinity, handling, etc., the inorganic salt is preferably a carbonate or a phosphate, more preferably an alkali metal salt of a carbonate or a phosphate, and further preferably trisodium phosphate, sodium carbonate, or potassium carbonate. These inorganic salts may be used alone or in combination of two or more.

[0028] The content of the inorganic salt in the first agent is not particularly limited, but is preferably 0.01 to 40.0% by mass or less. The lower limit of the content of the inorganic salt is more preferably 0.05% by mass or more, even more preferably 0.1% by mass or more, and particularly preferably 0.2% by mass or more. On the other hand, the upper limit of the content of the inorganic salt is more preferably 20.0% by mass or less, even more preferably 10.0% by mass or less, and particularly preferably 5.0% by mass or less. By setting the content of the inorganic salt to 0.01 to 40.0% by mass, the effects of the present invention can be further exhibited.

[0029] The ratio of the cystine content to the inorganic salt content (cystine / inorganic salt) is not particularly limited, but is preferably 0.01 to 10. The lower limit is more preferably 0.03 or more, even more preferably 0.05 or more, and particularly preferably 0.1 or more. The upper limit is more preferably 5 or less, even more preferably 3 or less, and particularly preferably 2 or less. By adjusting the ratio of the cystine content to the inorganic salt content (cystine / inorganic salt) to 0.01 to 10, the effect of the present invention can be further exerted. More specifically, by adjusting the cystine / inorganic salt to 0.01 to 10, the repair feeling and elasticity of the hair are improved.

[0030] The second composition, the hydrous cystine-containing composition, contains water. It may contain a polyhydric alcohol. Examples of the polyhydric alcohol include glycols and glycerins. Examples of the glycols include ethylene glycol, polyethylene glycol, highly polymerized polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, isoprene glycol, and 1,3-butylene glycol. Examples of the glycerins include glycerin, diglycerin, and polyglycerin. Of these polyhydric alcohols, only one may be contained alone, or two or more may be contained in combination. By containing a polyhydric alcohol, the feel of the hair can be improved.

[0031] (Oligosaccharides) The first composition, the second composition, and the hydrous cystine-containing composition preferably contain an oligosaccharide. When an oligosaccharide is used, the effect of the present invention can be further enhanced. More specifically, by containing an oligosaccharide, the elasticity and repair feeling of hair are improved.

[0032] In the present specification, an oligosaccharide is a compound having a sugar chain structure in which 2 to 20 monosaccharides are bonded. Specifically, disaccharides include trehalose, sucrose, maltose, lactose, sucralose, melibiose, etc., trisaccharides include raffinose, maltotriose, sialyllactose, etc., and other oligosaccharides include glucosyltrehalose, etc. In view of improving the elasticity of hair, it is particularly preferable to contain trehalose.

[0033] The content of oligosaccharide in the first agent is not particularly limited, but is, for example, 0.01 to 50% by mass. The lower limit of the content of oligosaccharide is preferably 0.1% by mass or more, more preferably 1% by mass or more, and even more preferably 2% by mass or more. The upper limit of the content of oligosaccharide is preferably 40% by mass or less, more preferably 30% by mass or less, even more preferably 20% by mass or less, and particularly preferably 10% by mass or less.

[0034] [Ingredients to be mixed into the second agent] The second agent contains an organic acid or an inorganic acid. Examples of the organic acid include tartaric acid, levulinic acid, lactic acid, glycolic acid, acetic acid, citric acid, malic acid, succinic acid, fumaric acid, maleic acid, oxalic acid, ascorbic acid, etc. Examples of the inorganic acid include hydrochloric acid, sulfuric acid, nitric acid, etc. Note that these organic acids and inorganic acids may be used alone or in combination of two or more. From the viewpoint of ease of handling, organic acids are preferred.

[0035] The pH of the second agent in the hair treatment composition of the present invention is 2 to 5. A pH of 2 or higher can prevent squeaks caused by excessive tightening of the hair. A pH of 5 or lower causes precipitation (insolubilization) of cystine that has penetrated into the hair in the first agent, providing a hair repair effect. The pH of the second agent is measured at 25° C. when the second agent is dissolved in water at a concentration of 10% by mass.

[0036] [Other ingredients] In addition to the above-mentioned components, other components may be blended, if necessary, in the first or second agent in the hair treatment composition of the present invention. Examples of the other components include oily components, solvents, surfactants, polymeric compounds, excipients, preservatives, chelating agents, plant extracts, herbal extracts, vitamins, fragrances, antioxidants, and ultraviolet absorbers. These other components may be used alone or in combination of two or more.

[0037] Examples of the oily component include fats and oils, waxes, hydrocarbons, higher fatty acids, alkyl glyceryl ethers, esters, and silicones.

[0038] Examples of fats and oils include olive oil, camellia oil, shea butter, almond oil, safflower oil, sunflower oil, soybean oil, cottonseed oil, sesame oil, corn oil, rapeseed oil, rice bran oil, rice germ oil, grape seed oil, avocado oil, macadamia nut oil, castor oil, coconut oil, and evening primrose oil, etc. These may be used alone or in combination of two or more. Examples of waxes include candelilla wax, carnauba wax, jojoba oil, lanolin, etc. These may be used alone or in combination of two or more. The blending ratio of the oil or wax is not particularly limited, but is preferably from 0.1 to 10% by mass, and more preferably from 0.2 to 5% by mass, based on the hair treatment composition.

[0039] Examples of the hydrocarbon include paraffin, olefin oligomer, polyisobutene, hydrogenated polyisobutene, mineral oil, squalane, polybutene, polyethylene, microcrystalline wax, and petrolatum, etc. These may be used alone or in combination of two or more. The blending ratio of the hydrocarbon is not particularly limited, but is preferably from 0.1 to 10 mass %, and more preferably from 0.5 to 5 mass %, based on the hair treatment composition.

[0040] Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, isostearic acid, 12-hydroxystearic acid, oleic acid, lanolin fatty acid, etc. These may be used alone or in combination of two or more. The blending ratio of the higher fatty acid is not particularly limited, but is preferably from 0.1 to 10 mass %, and more preferably from 0.5 to 5 mass %, based on the hair treatment composition.

[0041] Examples of alkyl glyceryl ethers include batyl alcohol, chimyl alcohol, selachyl alcohol, isostearyl glyceryl ether, etc. These may be used alone or in combination of two or more. The blending ratio of the alkyl glyceryl ether is not particularly limited, but is preferably from 0.1 to 10% by mass, and more preferably from 0.5 to 5% by mass, based on the hair treatment composition.

[0042] Examples of the ester include diisopropyl adipate, isopropyl myristate, cetyl octanoate, isononyl isononanoate, octyldodecyl myristate, isopropyl palmitate, stearyl stearate, myristyl myristate, isotridecyl myristate, 2-ethylhexyl palmitate, octyldodecyl ricinoleate, cholesteryl / lanosteryl of fatty acid having 10 to 30 carbon atoms, cetyl lactate, lanolin acetate, ethylene glycol di-2-ethylhexanoate, pentaerythritol fatty acid ester, dipentaerythritol fatty acid ester, cetyl caprate, glyceryl tricaprylate, diisostearyl malate, dioctyl succinate, diethoxyethyl succinate, and cetyl 2-ethylhexanoate. These may be used alone or in combination of two or more. The blending ratio of the ester is not particularly limited, but is preferably from 0.2 to 10% by mass, and more preferably from 0.5 to 5% by mass, based on the hair treatment composition.

[0043] Examples of silicones include dimethylpolysiloxane (dimethicone), decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, terminal hydroxyl group-modified dimethylpolysiloxane (dimethiconol), highly polymerized silicone having an average degree of polymerization of 650 to 10,000, amino-modified silicone, polyether-modified silicone [e.g., (PEG / PPG / butylene / dimethicone) copolymer], betaine-modified silicone, alkyl-modified silicone, alkoxy-modified silicone, mercapto-modified silicone, carboxy-modified silicone, and fluorine-modified silicone. These may be used alone or in combination of two or more.

[0044] Examples of the amino-modified silicones include aminopropylmethylsiloxane-dimethylsiloxane copolymer (INCI name: aminopropyl dimethicone), aminoethylaminopropylsiloxane-dimethylsiloxane copolymer (INCI name: amodimethicone), aminoethylaminopropylmethylsiloxane-dimethylsiloxane copolymer (INCI name: trimethylsilylamodimethicone), and the like.

[0045] The blending ratio of the silicone is not particularly limited, but is preferably from 0.1 to 10 mass %, and more preferably from 0.5 to 7 mass %, based on the hair treatment composition.

[0046] Examples of the solvent include organic solvents. Examples of the organic solvent include ethanol, isopropanol, benzyl alcohol, benzyloxyethanol, etc. These solvents may be used alone or in combination of two or more. The blending ratio of the solvent is not particularly limited, but is preferably from 0.1 to 10% by mass, and more preferably from 0.5 to 7% by mass, based on the hair treatment composition.

[0047] The surfactants can be used as cleaning components, as solubilizers for solubilizing the various components, and to adjust the viscosity of the composition or improve the viscosity stability. The surfactant may be a nonionic surfactant, a cationic surfactant, an anionic surfactant, or an amphoteric surfactant.

[0048] Examples of nonionic surfactants include alkylene polyoxypropylene alkyl ethers, alkylene sorbitan fatty acid esters, alkylene alkyl glycol fatty acid esters, polyoxyalkylene fatty acid amides, aliphatic alkanolamides, and alkyl glucosides. Examples of alkylene-polyoxypropylene alkyl ethers include polyoxyethylene (hereinafter also referred to as "POE") cetyl ether, POE stearyl ether, POE behenyl ether, POE oleyl ether, POE lauryl ether, POE octyldodecyl ether, POE hexyldecyl ether, POE isostearyl ether, POE nonylphenyl ether, and POE octylphenyl ether.

[0049] Examples of alkylene sorbitan fatty acid esters or alkylene alkyl glycol fatty acid esters include POE sorbitan monooleate, POE sorbitan monostearate, POE sorbitan monopalmitate, POE sorbitan monolaurate, POE sorbitan trioleate, POE glycerin monostearate, POE glycerin monomyristate, POE sorbit tetraoleate, POE sorbit hexastearate, POE sorbit monolaurate, POE sorbit beeswax, polyethylene glycol monooleate, monostearate, POE sorbitan monolaurate, POE sorbitan ... Examples of such fatty acids include polyethylene glycol tearate, polyethylene glycol monolaurate, lipophilic glyceryl monooleate, lipophilic glyceryl monostearate, self-emulsifying glyceryl monostearate, sorbitan monooleate, sorbitan sesquioleate, sorbitan trioleate, sorbitan monostearate, sorbitan monopalmitate, sorbitan monolaurate, sucrose fatty acid esters, decaglyceryl monolaurate, decaglyceryl monostearate, decaglyceryl monooleate, and decaglyceryl monomyristate.

[0050] Examples of polyoxyalkylene fatty acid amides or aliphatic alkanolamides include polyoxyethylene (2EO) monoethanolamide laurate, polyoxyethylene (3EO) monoethanolamide laurate, polyoxyethylene (5EO) monoethanolamide laurate, polyoxyethylene (10EO) monoethanolamide laurate, polyoxyethylene (15EO) monoethanolamide laurate, polyoxyethylene (2EO) monoethanolamide coconut oil fatty acid, polyoxyethylene (5EO) monoethanolamide coconut oil fatty acid, polyoxyethylene (10EO) monoethanolamide coconut oil fatty acid, and polyoxypropylene (12EO) monoethanolamide myristic acid. Among them, polyoxyethylene (2EO) monoethanolamide laurate, polyoxyethylene (3EO) monoethanolamide laurate, polyoxyethylene (5EO) monoethanolamide laurate, polyoxyethylene (10EO) monoethanolamide laurate, and polyoxyethylene (15EO) monoethanolamide laurate are preferred. Examples of the alkyl glucoside include alkyl (C8-16) glucoside, polyoxyethylene methyl glucoside, and polyoxyethylene dioleate methyl glucoside. These nonionic surfactants may be used alone or in combination of two or more kinds.

[0051] The blending ratio of the nonionic surfactant is not particularly limited, but is preferably 0.1 to 10 mass % and more preferably 0.1 to 5 mass % relative to the first or second agent.

[0052] Examples of cationic surfactants include lauryl trimethyl ammonium chloride, cetyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, alkyl trimethyl ammonium chloride, distearyl dimethyl ammonium chloride, cetyl trimethyl ammonium bromide, stearyl trimethyl ammonium bromide, lanolin fatty acid aminopropyl ethyl dimethyl ammonium ethyl sulfate, stearyl trimethyl ammonium saccharin, cetyl trimethyl ammonium saccharin, methacryloyloxyethyl trimethyl ammonium chloride, and behenyl trimethyl ammonium methyl sulfate. These may be used alone or in combination of two or more. The content of the cationic surfactant is not particularly limited, but is preferably 0.1 to 10% by mass, and more preferably 0.1 to 7% by mass, relative to the first or second agent.

[0053] Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate and triethanolamine lauryl sulfate, alkyl ether sulfates such as sodium POE lauryl ether sulfate, sodium stearoyl methyl taurate, triethanolamine dodecylbenzenesulfonate, and sodium tetradecenesulfonate. Other examples include (C6-C24) alkyl ether carboxylic acids, hydroxy(C6-C24) alkyl ether carboxylic acids, polyoxyalkylenated (C6-C24) alkyl ether carboxylic acids, polyoxyalkylenated (C6-C24) alkylaryl ether carboxylic acids, polyoxyalkylenated (C6-C24) alkylamide ether carboxylic acids, and alkali metal salts thereof (e.g., sodium salts, potassium salts, etc.), and organic amine salts thereof (e.g., monoethanolamine salts, diethanolamine salts, triethanolamine salts, and monoisopropanolamine salts, etc.). Further examples include POE lauryl ether phosphate and its salts, N-lauroyl glutamic acid salts, and N-lauroylmethyl-β-alanine salts, etc. These may be used alone or in combination of two or more. The blending ratio of the anionic surfactant is not particularly limited, but is preferably 0.1 to 10% by mass, and more preferably 0.1 to 5% by mass, relative to the first or second agent.

[0054] Examples of amphoteric surfactants include lauryl dimethylaminoacetate betaine, coconut oil fatty acid amidopropyl betaine solution, lauric acid amidopropyl betaine solution, sodium lauroamphoacetate, and sodium cocoamphoacetate, etc. These may be used alone or in combination of two or more. The blending ratio of the amphoteric surfactant is not particularly limited, but is preferably 0.1 to 10% by mass, and more preferably 0.1 to 5% by mass, relative to the first or second agent.

[0055] The polymer compound may be a nonionic polymer, an anionic polymer, a cationic polymer, or an amphoteric polymer, and the weight-average molecular weight of the polymer compound may be 100,000 or more.

[0056] Examples of nonionic polymers include hydroxyethyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, methyl cellulose, dextrin, galactan, pullulan, highly polymerized polyethylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, vinylpyrrolidone / vinyl acetate copolymer, vinylpyrrolidone / vinyl acetate / vinyl propionate copolymer (e.g., BASF, trade name "Ruviscol"), dimethylhydantoin formaldehyde resin, and poly(meth)acrylic. Examples of the copolymer include poly(meth)acrylic acid, (meth)acrylic acid copolymers, poly(meth)acrylic acid esters, (meth)acrylic acid ester copolymers, poly(meth)acrylamides, (meth)acrylic acid amide copolymers, etc. These may be used alone or in combination of two or more. The blending ratio of the nonionic polymer is not particularly limited, but is preferably 0.01 to 3 mass % and more preferably 0.1 to 1 mass % relative to the first or second agent.

[0057] Examples of anionic polymers include xanthan gum, carrageenan, sodium alginate, gum arabic, pectin, and carboxyvinyl polymers, etc. These may be used alone or in combination of two or more. The blending ratio of the anionic polymer is not particularly limited, but is preferably 0.01 to 1 mass % relative to the first or second agent, and more preferably 0.01 to 0.5 mass %.

[0058] Examples of cationic polymers include cationic celluloses such as O-[2-hydroxy-3-(trimethylammonio)propyl]hydroxyethylcellulose chloride, O-[2-hydroxy-3-(lauryldimethylammonio)propyl]hydroxyethylcellulose chloride, and hydroxyethylcellulose dimethyl diallyl ammonium chloride; cationic guar gums such as O-[2-hydroxy-3-(trimethylammonio)propyl]guar gum chloride; and cationic dextrans such as dextran hydroxypropyltrimethylammonium ether chloride. Cationized polysaccharides obtained by cationizing polysaccharides such as cellulose derivatives, natural gums, starches, and dextran; N-[2-hydroxy-3-(trimethylammonio)propyl] chloride hydrolyzed casein, N-[2-hydroxy-3-(trimethylammonio)propyl] chloride hydrolyzed collagen, N-[2-hydroxy-3-(trimethylammonio)propyl] chloride hydrolyzed silk, N-[2-hydroxy-3-(trimethylammonio)propyl] chloride hydrolyzed keratin, N-[2-hydroxy-3-(trimethylammonio)propyl] chloride hydrolyzed Dehydrated wheat protein, hydrolyzed conchiolin with N-[2-hydroxy-3-(trimethylammonio)propyl] chloride, hydrolyzed keratin with N-[2-hydroxy-3-(stearyldimethylammonio)propyl] chloride, hydrolyzed collagen with N-[2-hydroxy-3-(stearyldimethylammonio)propyl] chloride, hydrolyzed silk with N-[2-hydroxy-3-(stearyldimethylammonio)propyl] chloride, hydrolyzed casein with N-[2-hydroxy-3-(stearyldimethylammonio)propyl] chloride, Hydrolyzed wheat protein, N-[2-hydroxy-3-(stearyldimethylammonio)propyl] chloride hydrolyzed conchiolin protein, N-[2-hydroxy-3-(lauryldimethylammonio)propyl] chloride hydrolyzed keratin, N-[2-hydroxy-3-(lauryldimethylammonio)propyl] chloride hydrolyzed collagen, N-[2-hydroxy-3-(lauryldimethylammonio)propyl] chloride hydrolyzed silk, N-[2-hydroxy-3-(lauryldimethylammonio)propyl] chloride hydrolyzed casein,Hydrolyzed proteins are obtained by cationizing hydrolyzed proteins such as N-[2-hydroxy-3-(lauryldimethylammonio)propyl] hydrolyzed wheat protein chloride, N-[2-hydroxy-3-(lauryldimethylammonio)propyl] hydrolyzed conchiolin chloride, N-[2-hydroxy-3-(cocoalkyldimethylammonio)propyl] hydrolyzed soy protein chloride, N-[2-hydroxy-3-(cocoalkyldimethylammonio)propyl] hydrolyzed casein chloride, N-[2-hydroxy-3-(cocoalkyldimethylammonio)propyl] hydrolyzed collagen chloride, N-[2-hydroxy-3-(cocoalkyldimethylammonio)propyl] hydrolyzed silk chloride, N-[2-hydroxy-3-(cocoalkyldimethylammonio)propyl] hydrolyzed keratin chloride, and N-[2-hydroxy-3-(cocoalkyldimethylammonio)propyl] hydrolyzed conchiolin chloride, Cationic hydrolyzed proteins that can be used include cationized vinyl or acrylic polymers such as dimethyldiallylammonium chloride-acrylamide copolymer, β-methacryloxyethyltrimethylammonium-acrylamide copolymer, vinylpyrrolidone-N,N-dimethylaminoethyl methacrylic acid copolymer diethyl sulfate, and polydimethylmethylene piperidinium chloride; polyglycol polyamine condensates such as N,N-dimethylaminoethyl diethyl methacrylate sulfate-N,N-dimethylacrylamide-polyethylene glycol dimethacrylate; dimethyl adipionate-aminohydroxypropyl diethyl triamine copolymer; and aminoethylaminopropyl-methyl polysiloxane copolymer. Among these, dimethyldiallylammonium chloride-acrylamide copolymer is preferred. These cationic polymers may be used alone or in combination of two or more kinds.

[0059] The content of the cationic polymer is not particularly limited, but is preferably 0.01 to 3 mass % and more preferably 0.1 to 1 mass % relative to the first or second agent.

[0060] Examples of amphoteric polymers include N-methacryloylethyl N,N-dimethylammonium α-N-methylcarboxybetaine-butyl methacrylate copolymer (trade name: Yukaformer AM-75; manufactured by Mitsubishi Chemical Corporation), hydroxypropyl acrylate-butylaminoethyl methacrylate-octylamide acrylate copolymer (trade name: Amphomer 28-4910; manufactured by National Starch Co.), dimethyldiallylammonium chloride-acrylic acid copolymer (trade name: Merquat 280, 295; manufactured by Ondeo Nalco Co.), dimethyldiallylammonium chloride-acrylamide-acrylic acid terpolymer (trade name: Merquat Plus 3330, 3331; manufactured by Ondeo Nalco Co.), and acrylic acid-methyl acrylate-methacrylamidopropyltrimethylammonium chloride copolymer (trade name: Merquat 2001; manufactured by Ondeo Nalco Co.). These may be used alone or in combination of two or more kinds. The mixing ratio of the amphoteric polymer is not particularly limited, but is preferably 0.01 to 1 mass % and more preferably 0.1 to 1 mass % relative to the first or second agent.

[0061] Excipients are raw materials used to adjust the volume of solid preparations such as powders, granules, tablets, and tablets, and examples thereof include sodium sulfate, starch, and maltitol.

[0062] Examples of the preservative include phenoxyethanol, paraben, methylparaben, sodium benzoate, etc. These may be used alone or in combination of two or more.

[0063] Examples of the chelating agent include edetic acid (ethylenediaminetetraacetic acid (EDTA)) and its salts, diethylenetriaminepentaacetic acid and its salts, and hydroxyethanediphosphonic acid (etidronic acid, HEDP) and its salts, etc. These may be used alone or in combination of two or more.

[0064] Examples of the antioxidant include ascorbic acid, sulfite, tocopherol, tocopherol acetate, etc. These may be used alone or in combination of two or more.

[0065] Examples of the plant extracts include aloe extract, scutellaria extract, hypericum extract, licorice extract, perilla extract, hawthorn extract, rosemary extract, turmeric extract, kasou extract, burdock extract, ginger extract, mallow extract, tea extract, saxifrage extract, yuzu extract, capillus capillifern leaf extract, peach leaf extract, sugar maple sap, soapberry extract, mandarin orange peel extract, hamamelis leaf extract, etc. These may be used alone or in combination of two or more. In addition, the plant extract is preferably one containing polyphenol, specifically, ferns capillus-veneris leaf extract, peach leaf extract, sugar maple sap, soapberry extract, mandarin orange peel extract, hamamelis leaf extract, etc. are listed. Ferns capillus-veneris leaf extract and peach leaf extract are preferred because they have the effect of generating cystine (disulfide bond) from cysteine ​​(thiol group) in hair. In addition, from the viewpoint of enhancing this effect, it is particularly preferred that the agent containing the plant extract has a pH of 7.0 or more.

[0066] [Form of hair treatment composition] The formulation of the hair treatment composition of the present invention is not particularly limited. Specifically, for example, the first and second agents may each be used in an appropriate formulation such as an aqueous solution, cream, or emulsion. They may also be in the form of an aerosol or non-aerosol.

[0067] [Method of using the hair treatment composition] In a hair treatment method using the hair treatment composition of the present invention, a first agent containing cystine is applied to the hair, and then a second agent having a pH of 2 to 5 is applied to the hair. The composition is characterized in that it comprises a solid cystine-containing composition that contains solid cystine and is substantially free of water, or a hydrous cystine-containing composition that contains cystine and water and has a pH of 8.0 or less, and the pH of the first agent when applied to hair is 8.5 to 12.5.

[0068] Furthermore, a hair treatment method using the hair treatment composition of the present invention specifically comprises the step of preparing a first agent having a pH of 8.5 to 12.5 using a solid cystine-containing composition that contains solid cystine and is substantially free of water, or a hydrous cystine-containing composition that contains cystine and water and has a pH of 8.0 or less.

[0069] When a solid cystine-containing composition is used, the step of preparing the first agent includes, for example, a step of mixing a first composition containing cystine and substantially free of water with a second composition containing water to prepare the first agent.

[0070] When a hydrous cystine-containing composition is used, the step of preparing the first agent includes, for example, a step of mixing the hydrous cystine-containing composition with an alkali-containing composition that contains an alkaline agent to prepare the first agent.

[0071] Through the above steps, the solid cystine-containing composition or the hydrous cystine-containing composition is distributed, and is mixed with another composition before application to hair to prepare the first agent. When mixing the solid cystine-containing composition or the hydrous cystine-containing composition with another composition in the step of preparing the first agent, the first agent may be prepared by mixing the respective compositions before application to hair, or the first agent may be prepared by applying the respective compositions to hair and then mixing the respective compositions on the hair.

[0072] The timing of application of the second agent is not particularly limited as long as it is after the first agent has sufficiently penetrated into the hair. Specifically, for example, it can be within 30 minutes (particularly within 20 minutes, and even more preferably within 10 minutes) after the first agent is applied to the hair.

[0073] In the hair treatment composition of the present invention, the amount of the second agent used relative to the first agent is not particularly limited and may be appropriately adjusted depending on the application. Specifically, for example, the amount of the second agent used is, for example, 50 to 300 parts by mass, and preferably 100 to 200 parts by mass, relative to 100 parts by mass of the first agent. EXAMPLES

[0074] The present invention will be described in detail below with reference to examples, but the technical scope of the present invention is not limited to these examples.

[0075] [Preparation of hair treatment composition] <Preparation of the first agent> The first composition and the second composition were mixed in a ratio of 1:9 to prepare a first agent having the composition shown in Tables 1 and 2. The values ​​of the first composition and the second composition shown in Tables 1 and 2 are the mass % values ​​in the first agent. The pH was adjusted using tartaric acid and arginine.

[0076] <Preparation of the second agent> A second agent having the composition shown below was prepared. Cetearyl alcohol 4% by weight Myristyl alcohol 1.5% by mass Behentrimonium chloride 2.5% by mass Triethylhexanoin 2% by mass Dimethicone 2% by weight Tartaric acid 0.5% by mass Lactic acid 1.5% by mass Purified water remainder Total 100% by mass

[0077] [Preparing the hair bundle] Hair bundle samples (same human hair, hair diameter: 75 to 95 micrometers) were treated with "Promaster EX LT" (Hoyu Corporation, bleach) at 30°C for 30 minutes, then rinsed with water, shampooed, and dried with a hair dryer (bleaching treatment). In this manner, the above-mentioned bleaching treatment was carried out to prepare damaged hair bundles.

[0078] [Evaluation method] 5 g of the first agent of Examples 1 to 14 and Comparative Examples 1 to 3 was evenly applied to the entire damaged hair bundle of 10 g prepared as described above, and the damaged hair bundle was treated at 30°C for 3 minutes. Then, 7.5 g of the second agent was evenly applied to the entire damaged hair bundle treated in Examples 1 to 12 and Comparative Examples 1 to 3, and the damaged hair bundle was treated at 30°C for 5 minutes, and then washed with water. Note that, in Example 4, washing with water was performed before applying the second agent, and the first agent was washed away. After washing away the second agent, the hair bundle was towel-dried, and then dried with a hair dryer to obtain a treated hair bundle. The treated hair bundle treated with each hair treatment composition was evaluated for the repair feeling of the hair and the elasticity of the hair. In addition, the first agent was also evaluated for the generation of odor and the change in color. The evaluation method is as follows.

[0079] <Hair repair feeling> The repair feel of hair was evaluated as follows in a sensory test by 10 panelists who are experts in hair feel. The 10 panelists compared the feel of the treated hair bundle when running their fingers through the hair bundle, and when 9 or more panelists rated the treated hair bundle as smoother and easier to run their fingers through than the damaged hair bundle, they gave a rating of "5", when 7 to 8 panelists rated it as "4", when 5 to 6 panelists rated it as "3", when 3 to 4 panelists rated it as "2", and when 2 or less panelists rated it as "1". The evaluation results are shown in Tables 1 and 2 under the heading "Hair repair feeling."

[0080] <Hair elasticity> The elasticity of the hair was evaluated as follows in a sensory test by 10 panelists who are experts in hair feel. The 10 panelists compared the feel of the treated hair strand with that of the damaged hair strand when they touched it. If 9 or more panelists rated the treated hair strand as having improved elasticity and strength compared to the damaged hair strand, they gave a rating of "5", if 7-8 panelists rated it as "4", if 5-6 panelists rated it as "3", if 3-4 panelists rated it as "2", and if 2 or less panelists rated it as "1". The evaluation results are shown in Tables 1 and 2 under "Hair elasticity."

[0081] <Odor suppression> "Odor suppression" was evaluated by sensory evaluation of whether or not an odor different from the odors generated by the first and second compositions (hereinafter referred to as "off-odor") was detected after leaving the first agent mixed at the time of use for 20 minutes. However, for Comparative Example 3, the evaluation was performed after 2 weeks had passed since mixing. For this evaluation item, 10 panelists evaluated the smell of the first agent, choosing between "no unpleasant odor is detected" or "an unpleasant odor is detected." If 9 or more panelists out of 10 answered "no unpleasant odor is detected," the rating was given as "5," if 7 to 8 panelists answered "4," if 5 to 6 panelists answered "3," if 3 to 4 panelists answered "2," and if 2 or less panelists answered "1." The evaluation results are shown in the "Odor Suppression" section of Tables 1 and 2.

[0082] <Prevents discoloration> "Discoloration inhibition" was evaluated by visually checking whether the color of the first agent had changed from the color at the time of mixing after leaving the first agent mixed for 20 minutes. However, in the case of Comparative Example 3, the evaluation was performed after 2 weeks had passed since mixing. For this evaluation item, 10 panelists compared the first formulation that had been mixed for 20 minutes with the first formulation that had been mixed immediately before the evaluation, and scored it according to the following criteria: An average score of 2.8 or more was assigned a "5," 2.5 or more but less than 2.8 a "4," 2.0 or more but less than 2.5 a "3," 1.5 or more but less than 2.0 a "2," and less than 1.5 a "1." The evaluation results are shown in the "Discoloration Inhibition" section of Tables 1 and 2. (Evaluation Criteria) 3: Almost no discoloration. 2: Slightly discolored. 1: Significant discoloration.

[0083] [Table 1]

[0084] With reference to Table 1, the effect of the passage of time after preparation of the first agent will be examined. Comparing Example 1 and Comparative Example 3, Example 1, which was mixed at the time of use, showed excellent results in all evaluation items including hair repair feeling, hair elasticity, odor suppression, and discoloration suppression. On the other hand, Comparative Example 3, which was prepared two weeks ago, did not show good results in any evaluation items.

[0085] The pH value of the first agent will be examined. Comparing Example 1, Comparative Example 1, and Comparative Example 2, Example 1, which has a pH of 10, showed excellent results in all of the evaluation items of hair repair feeling, hair elasticity, odor suppression, and discoloration suppression. On the other hand, Comparative Example 1, which has a pH of less than 8.5, showed good results in odor suppression and discoloration suppression, but did not show good results in hair repair feeling and hair elasticity. Moreover, Comparative Example 2, which has a pH of more than 12.5, did not show good results in any of the evaluation items.

[0086] The inorganic salt of the alkaline agent, component (B), will be examined. When Examples 1 to 3 were examined, all evaluation items were good, and it was found that these inorganic salts of component (B) are applicable.

[0087] In Example 4, the first agent was washed off before the treatment with the second agent. As a result, the hair repair feeling and hair elasticity feeling were slightly inferior to those of Example 1, but the effect was still recognized.

[0088] Comparing Example 1, Example 5, and Example 6, it can be seen that the inclusion of oligosaccharides improves the elasticity of hair. Also, the addition of trehalose was found to have a particularly excellent effect.

[0089] [Table 2]

[0090] The cystine content and the inorganic salt content are examined with reference to Table 2. Examination of Examples 1 and 7 to 9 reveals that a particularly excellent effect is observed when the inorganic salt content exceeds 0.2% by mass. Examination of Examples 1 and 10 to 12 reveals that a particularly excellent effect is observed when the cystine content exceeds 0.1% by mass.

[0091] In addition, Example 13 contained 0.1% by mass of cystine and 0.2% by mass of inorganic salt, and showed an effect equivalent to that of Example 9 (1% by mass of cystine, 0.2% by mass of inorganic salt) and a better effect than Example 11 (0.1% by mass of cystine, 2% by mass of inorganic salt). It is believed that the elasticity of the hair was improved in Example 13 by containing 9% by mass or more of trehalose.

[0092] In addition, Example 14 contains 2% by mass of cystine and 4% by mass of inorganic salt, but Example 1 (1% by mass of cystine, 2% by mass of inorganic salt) showed better results in terms of hair elasticity. In Example 1, the content of inorganic salt is not too high, and the content of trehalose is also high, which is thought to be the reason for the improved hair elasticity.

[0093] Next, the ratio of the cystine content to the inorganic salt content (cystine / inorganic salt) will be considered. Looking at Example 1 and Examples 7 to 11, good evaluation results were observed in all Examples. Therefore, it can be said that the effect of the present invention is further enhanced when the ratio of the cystine content to the inorganic salt content (cystine / inorganic salt) is 0.05 to 5.

[0094] [Prescription example] The following compositions were prepared: first composition Ai-1 (powder) shown in Table 3, first composition Ai-2 (powder) shown in Table 4, and hydrous cystine-containing composition Ai-3 (cream) shown in Table 5. In addition, the following compositions Aii-1 (liquid) shown in Table 6, second composition Aii-2 (gel) shown in Table 7, second composition Aii-3 (emulsion) shown in Table 8, and composition Aii-4 (liquid) containing an alkaline agent shown in Table 9 were prepared. In addition, a second agent B-1 (cream) shown in Table 10 was prepared.

[0095] [Table 3]

[0096] [Table 4]

[0097] [Table 5]

[0098] [Table 6]

[0099] [Table 7]

[0100] [Table 8]

[0101] [Table 9]

[0102] [Table 10]

[0103] As shown in Table 11, the first agents of Formulation Examples 1 to 6 were prepared by combining the first compositions shown in Tables 3 and 4 and the second compositions shown in Tables 6 to 8. The first agent of Formulation Example 7 was prepared by combining the hydrous cystine-containing composition shown in Table 5 and the composition containing an alkaline agent shown in Table 9. Then, the first agents of Formulation Examples 1 to 7 and the second agent shown in Table 10 were used to perform evaluation in the same manner as in Example 1 using damaged hair bundles.

[0104] [Table 11]

[0105] The damaged hair strands treated with the hair treatment compositions of Formulation Examples 1 to 7 achieved excellent results in all of the evaluation items of hair repair feeling, hair elasticity, odor suppression, and discoloration suppression. [Industrial Applicability]

[0106] The hair treatment composition of the present invention can be used on human body hair such as head hair, beard, eyebrows, leg hair, etc. In addition, it may also be used on the body hair of animals such as pets.

[0107] The hair treatment composition of the present invention can be used in a beauty salon or a barber shop, and can also be used for self-treatment at home.

[0108] The hair treatment method of the present invention can be used for human body hair such as head hair, beard, eyebrows, leg hair, etc. In addition, it may be used for body hair of animals such as pets.

[0109] The hair treatment method of the present invention can be used in a beauty salon or a barber shop, and can also be used for self-treatment at home.

Claims

1. A method for treating a cystine-containing disease comprising the steps of: A hair treatment composition comprising a first agent applied to hair and then a second agent applied to hair, the first agent comprises a solid cystine-containing composition which contains solid cystine and has a loss on drying of 5% or less according to the loss on drying test method (1 g, 105° C., 4 hours) in the Japanese Pharmacopoeia, and a composition which contains water; The pH of the first agent when applied to hair is 8.5 to 12.5; A hair treatment composition, comprising the solid cystine-containing composition and the water-containing composition, which are mixed before use.

2. The hair treatment composition described in claim 1, characterized in that the solid cystine-containing composition contains an inorganic salt that exhibits alkaline properties when dissolved in water.

3. 3. The hair treatment composition according to claim 2, wherein the ratio of the cystine content to the inorganic salt content in the first agent (cystine / inorganic salt) is 0.025 to 5.

4. A method for treating a cystine-containing infection comprising the steps of: A hair treatment composition comprising a first agent applied to hair and then a second agent applied to hair, The first agent comprises a hydrous cystine-containing composition containing cystine and water and having a pH of 8.0 or less, and a composition containing an alkaline agent; The pH of the first agent when applied to hair is 8.5 to 12.5; A hair treatment composition, comprising the hydrous cystine-containing composition and the alkaline agent-containing composition mixed before use.

5. The hair treatment composition according to any one of claims 1 to 4, wherein the first agent contains an oligosaccharide.

6. A method for treating a cystine-containing infection comprising the steps of: A hair treatment method using a hair treatment composition, comprising applying the first agent to hair and then applying the second agent to hair, The present invention comprises a solid cystine-containing composition which contains solid cystine and has a loss on drying of 5% or less according to the loss on drying test method (1 g, 105° C., 4 hours) in the Japanese Pharmacopoeia, and a composition which contains water; The pH of the first agent when applied to hair is 8.5 to 12.5; A hair treatment method comprising mixing the solid cystine-containing composition and the water-containing composition before use.

7. A method for treating a cystine-induced inflammatory bowel disease comprising the steps of: A hair treatment method using a hair treatment composition, comprising applying the first agent to hair and then applying the second agent to hair, The present invention comprises a hydrous cystine-containing composition containing cystine and water and having a pH of 8.0 or less, and a composition containing an alkaline agent, The pH of the first agent when applied to hair is 8.5 to 12.5; A hair treatment method comprising mixing the hydrous cystine-containing composition and the composition containing an alkaline agent before use.

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