Efficacy enhancing compositions and uses thereof

Abstract

This efficacy-enhancing composition contains high molecular weight hyaluronic acid or its salt, hydrolyzed hyaluronic acid or its salt, acetylated hyaluronic acid or its salt, tetrahydropyrimidine or its derivative, ergothioneine, yeast-rice fermentation filtrate, and aminobutyric acid. While moisturizing and repairing the skin, the efficacy-enhancing composition improves the stability of high molecular weight active ingredients and increases their contact time with the skin, thereby improving the utilization rate of the high molecular weight active ingredients, reducing the amount of active ingredients used, saving costs, and reducing skin irritation caused by excessive use of certain active ingredients. It also increases the percutaneous absorption of small molecule active ingredients, increasing their utilization rate.

Description

[Technical field]

[0001] The present invention is in the field of biomedicine, and specifically relates to efficacy enhancing compositions and uses thereof. [Background technology]

[0002] The prerequisite for a cosmetic product to achieve maximum efficacy is that the active ingredients have good permeability and activity, and that the utilization rate of the active ingredients is increased.

[0003] Transdermal absorption of cosmetics refers to the process in which functional ingredients in cosmetics act on the skin surface or penetrate into the epidermis or dermis depending on the efficacy of the product, and accumulate and act at that site. The main difference between transdermal absorption of cosmetic active ingredients and drugs is that they do not need to penetrate the skin to enter the systemic circulation. For example, whitening agents in whitening products act on the basal layer of the skin to block melanin production, active ingredients in anti-aging products act on fibroblasts in the dermis layer to give the skin firmness, sunscreen agents in sunscreen products remain on the surface of the skin to absorb and reflect ultraviolet rays, while some moisturizing products act on the epidermis or dermis layer through different action mechanisms to improve the moisture content of the skin.

[0004] There are many factors that affect the percutaneous absorption of cosmetics, mainly including skin factors, the structure of active ingredients, substance concentration, cosmetic formulation, and external environment. Currently, in the market, it is common to enhance the permeability of cosmetics by selecting active ingredients similar to those of the skin or changing the cosmetic formulation, but the effect is monotonous and there is a certain limit to the penetration-promoting effect.

[0005] Therefore, there is an urgent need for an efficacy-promoting composition that can promote the penetration and absorption of active ingredients according to the location where each active ingredient exerts its effect, achieve accurate localization of the active ingredients, and rapidly exert skin care effects, while also improving the stability of the active ingredients, increasing the contact time of the active ingredients with the skin, and improving the utilization rate of the active ingredients. Summary of the Invention [Problem to be solved by the invention]

[0006] The present invention aims to provide an efficacy-promoting composition that can effectively improve the penetration and absorption of active ingredients and the stability of the active ingredients while moisturizing and rehydrating, thereby improving the utilization rate of the active ingredients and improving skin conditions. [Means for solving the problem]

[0007] Specifically, the present invention relates to the following aspects. 1. High molecular weight hyaluronic acid or its salt, hydrolyzed hyaluronic acid or its salt, acetylated hyaluronic acid or its salt, tetrahydropyrimidine or its derivative, ergothioneine, Saccharomyces / Rice Fermentation Liquid , and an efficacy enhancing composition comprising aminobutyric acid. 2. The polymeric hyaluronic acid or a salt thereof is 1 to 30% by mass, preferably 1 to 10% by mass, the hydrolyzed hyaluronic acid or a salt thereof is 2% by mass to 50% by mass, preferably 2 to 10% by mass, the acetylated hyaluronic acid or a salt thereof is 1 to 10% by mass, preferably 1 to 1.5% by mass, the tetrahydropyrimidine or a derivative thereof is 0.1% by mass to 10% by mass, preferably 0.3 to 5%, the ergothioneine is 2 to 20% by mass, preferably 3 to 10% by mass, the Saccharomyces / Rice Fermentation Liquid Item 2. The composition according to item 1, wherein the amount of the aqueous solution is 10 to 50% by mass, preferably 15 to 40% by mass, and the amount of the aminobutyric acid is 0.1 to 5% by mass, preferably 0.3 to 3% by mass. 3. On a weight part basis, the polymeric hyaluronic acid or its salt is 1 part by weight, the hydrolyzed hyaluronic acid or its salt is 0.2 to 2 parts by weight, preferably 0.5 to 1 part by weight, the acetylated 3. The composition according to item 1 or 2, wherein the amount of hyaluronic acid or a salt thereof is 0.05 to 1.5 parts by weight, preferably 0.1 to 0.5 parts by weight. 4. The composition according to any one of Items 1 to 3, wherein the molecular weight of the high molecular weight hyaluronic acid or a salt thereof is 1000 to 1800 kDa, preferably 1000 to 1500 kDa. 5. The composition according to any one of claims 1 to 4, wherein the molecular weight of the hydrolyzed hyaluronic acid is 1 kDa to 10 kDa, preferably 5 kDa to 10 kDa. 6. The composition according to any one of claims 1 to 5, wherein the molecular weight of the acetylated hyaluronic acid or a salt thereof is 20 kDa to 100 kDa, and the acetyl content is 20 to 40% by mass. 7. The tetrahydropyrimidine or a derivative thereof is Ectoine and hydroxy Ectoine selected from one or two kinds, preferably Ectoine The composition according to any one of claims 1 to 6, characterized in that it is 8. The composition further contains a preservative. In the composition, the preservative is 0.1 to 5% by mass, and is one or more selected from pentylene glycol, hexylene glycol, butylene glycol, and ethylhexylglycerin. The composition according to any one of claims 1 to 7, characterized in that it is 9. Use of the composition according to any one of claims 1 to 8 in skin care products or cosmetics. 10. Skin care products or cosmetics containing the composition according to any one of claims 1 to 8.

Advantages of the Invention

[0008] The present invention has the following beneficial effects. 1. Acetylated hyaluronic acid links high-molecular-weight hyaluronic acid and hydrolyzed hyaluronic acid with specific molecular weights at a specific blending ratio to construct a stable "I"-shaped channel in three-dimensional space, forming a long-term water supply channel from the moisturizing and water-retaining layer on the skin surface to the water replenishing layer deep in the skin, thereby effectively replenishing water and increasing the water content of the skin. 2. Due to the synergistic effect of tetrahydropyrimidine, ergothioneine, Saccharomyces / Rice Fermentation Liquid , and aminobutyric acid, the efficient operation of the "I"-shaped structure formed by sodium hyaluronate and its derivatives is ensured, thereby achieving more efficient repair of the skin barrier, repair of damage, and improvement of the skin surface condition. 3. The "I"-shaped efficacy promotion system constructed by seven components can replenish and repair moisture to the skin, enhance the stability of high-molecular efficacy components, increase the contact time between the efficacy components and the skin, thereby improving the utilization rate of the high-molecular efficacy components, reducing the usage amount of the efficacy components, saving costs, reducing skin irritation caused by excessive usage of some efficacy components, while increasing the transdermal absorption effect of small-molecular efficacy components and increasing the utilization rate of small-molecular efficacy components through the "I"-shaped channel.

Embodiments for Carrying Out the Invention

[0009] Hereinafter, the present invention will be further described with reference to examples. It should be understood that the examples are only used for further explaining the present invention and are not used for limiting the present invention.

[0010] Unless otherwise defined, the technical and scientific terms in this specification have the same meaning as commonly understood by those skilled in the art. In this specification, methods and materials similar or identical to those described herein can be applied in experiments or actual applications. However, the materials and methods will be described below. In case of contradiction, the definitions included in this specification shall prevail. Also, the materials, methods, and examples are for illustrative purposes only and are not limiting. Hereinafter, the present invention will be further described with reference to specific examples, but it does not limit the scope of the present invention.

[0011] The present invention provides an efficacy promotion composition containing high-molecular hyaluronic acid or its salt, hydrolyzed hyaluronic acid or its salt, acetylated hyaluronic acid or its salt, tetrahydropyrimidine or its derivative, ergothioneine, Saccharomyces / Rice Fermentation Liquid , and aminobutyric acid.

[0012] In one specific embodiment, the polymeric hyaluronic acid or its salt may be 1 to 30% by mass, for example, 1% by mass, 5% by mass, 10% by mass, 15% by mass, 20% by mass, 25% by mass, 30% by mass, preferably 1 to 10% by mass. The hydrolyzed hyaluronic acid or its salt may be 2% by mass to 50% by mass, for example, 2% by mass, 5% by mass, 10% by mass, 15% by mass, 20% by mass, 25% by mass, 30% by mass, 35% by mass, 40% by mass, 45% by mass, 50% by mass, preferably 2 to 10% by mass, and the acetylated hyaluronic acid or its salt may be 1 to 10% by mass, for example, 1% by mass, 1.2% by mass, 1.5% by mass, 2% by mass, 3% by mass, 4% by mass, 5% by mass, 6% by mass, 7% by mass, 8% by mass, 9% by mass, 10% by mass, preferably 1 to 1.5% by mass. The tetrahydropyrimidine or derivative thereof may be 0.1% by mass to 10% by mass, for example, 0.1%, 0.3%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10% by mass, and preferably 0.3 to 5% by mass. The ergothioneine may be 2% to 20% by mass, 2%, 3%, 5%, 10%, 15%, 20% by mass, and preferably 3 to 10% by mass. Saccharomyces / Rice Fermentation Liquid The content of the aminobutyric acid may be 0.1 to 5% by mass, for example, 0.1, 0.3, 0.5, 1, 2, 3, 4, 5, or 6% by mass, and preferably 0.3 to 3% by mass.

[0013] Hyaluronic acid (HA) is a polymeric polysaccharide naturally found in the interstitium of human tissue cells. It is widely used in the fields of medicine, skin care products, food, etc. It has various molecular weights, and HA of each molecular weight has different efficacy and expression. High molecular weight HA has excellent film-forming and moisture-retaining properties, low molecular weight hydrolyzed HA can penetrate the skin and deeply hydrate the skin, and acetylated HA can act as a bridge between the skin surface and hydrolyzed HA, and is a natural effective moisturizing and moisture-retaining factor.

[0014] By combining three different types of HA, a skin surface moisturizing and water retention layer mainly composed of polymerized HA formed into a film, a deep - layer water replenishing layer mainly composed of hydrolyzed HA, and a water transport layer of acetylated HA connecting the two parts are formed in the space to construct a long - term water replenishing and moisturizing channel in the shape of "工" in the three - dimensional space.

[0015] In one specific embodiment, the molecular weight of the high - molecular - weight hyaluronic acid or its salt is 1000 - 1800 kDa, for example, 1000 kDa, 1100 kDa, 1200 kDa, 1300 kDa, 1400 kDa, 1500 kDa, 1600 kDa, 1700 kDa, 1800 kDa, and preferably may be 1000 - 1500 kDa. The molecular weight of the hydrolyzed hyaluronic acid or its salt is 1 kDa - 10 kDa, for example, 1 kDa, 2 kDa, 3 kDa, 4 kDa, 5 kDa, 6 kDa, 7 kDa, 8 kDa, 9 kDa, 10 kDa, and preferably may be 5 kDa - 10 kDa. The molecular weight of the acetylated hyaluronic acid or its salt is 20 kDa - 100 kDa, for example, 20 kDa, 30 kDa, 40 kDa, 50 kDa, 60 kDa, 70 kDa, 80 kDa, 90 kDa, 100 kDa. The acetyl group in the acetylated hyaluronic acid or its salt may be 20 - 40% by mass, for example, 20% by mass, 25% by mass, 30% by mass, 35% by mass, 40% by mass.

[0016] In one specific embodiment, the polymeric hyaluronic acid or a salt thereof is 1 part by weight, and the hydrolyzed hyaluronic acid or a salt thereof is 0.2 to 2 parts by weight, for example, 0.2 parts by weight, 0.3 parts by weight, 0.4 parts by weight, 0.5 parts by weight, 0.6 parts by weight, 0.7 parts by weight, 0.8 parts by weight, 0.9 parts by weight, 1 parts by weight, 1.1 parts by weight, 1.2 parts by weight, 1.3 parts by weight, 1.4 parts by weight, 1.5 parts by weight, 1.6 parts by weight, 1.7 parts by weight, The amount of the acetylated hyaluronic acid or a salt thereof may be 0.05 to 1.5 parts by weight, for example, 0.05 parts by weight, 0.1 parts by weight, 0.2 parts by weight, 0.3 parts by weight, 0.4 parts by weight, 0.5 parts by weight, 1 part by weight, 1.1 parts by weight, 1.2 parts by weight, 1.3 parts by weight, 1.4 parts by weight, 1.5 parts by weight, preferably 0.1 to 0.5 parts by weight.

[0017] Ectoine (ECTOI N) is the most widely distributed compatible solute in the bacterial kingdom currently found, and is an important osmotic compensation solute that is compatible with intracellular metabolism and does not affect the function of biopolymers or physiological functions of cells. Due to the dense charge distribution on the surface, ectoine can further strengthen the hydrogen bonding between water molecules through electrostatic interaction with water molecules, reduce water activity, complex water molecules, and have a long-term moisturizing effect. Through its own high-density charge, it can strengthen the hydrogen bonding between water molecules and provide long-term moisturizing, and ectoine has excellent hydrophilicity, so that the above-mentioned C-shaped structure can more efficiently repair the skin barrier and repair damage.

[0018] In one specific embodiment, the tetrahydropyrimidine or derivative thereof is Ectoine and hydroxy Ectoine One or two selected from the following, preferably Ectoine It is.

[0019] Ergothioneine is a natural antioxidant that is distributed in certain tissues and organs of mammals and can be produced by fermentation. It can play a protective role on cells in the human body and has UV protection properties, making it an important active substance in the body. In synergy with ectoin, it can effectively protect the skin barrier and ensure the function of the "U"-shaped structure formed by sodium hyaluronate and its derivatives.

[0020] Saccharomyces / Rice Fermentation Liquid (Saccharomyces / Rice Ferment Filterate) is a natural ingredient produced by fermentation, which has the effect of increasing cell vitality and promoting cell renewal. It can effectively penetrate the thin film formed on the skin surface by high molecular weight HA, and remain on the skin surface for a long time, promoting the regeneration of surface damaged cells, and through synergistic action with ergothioneine and ectoin, it can improve the condition of the skin surface more efficiently and increase its moisturizing ability.

[0021] Aminobutyric acid can promote the proliferation of epidermal cells and the production of involucrin in keratinocytes, repair the barrier of the stratum corneum, reduce skin damage caused by ultraviolet rays, and enhance cell activity.

[0022] Tetrahydropyrimidine or its derivatives, ergothioneine, Saccharomyces / Rice Fermentation Liquid Aminobutyric acid effectively protects the skin barrier and ensures the stability and durability of the film formed on the skin surface by high molecular weight HA, thereby ensuring the efficient operation of the "U"-shaped structure formed by sodium hyaluronate and its derivatives.

[0023] The composition further contains a preservative, which is one or more preservatives selected from pentylene glycol, hexylene glycol, butylene glycol, and ethylhexylglycerin, and the preservative is present in an amount of 0.1 to 5% by mass in the composition.

[0024] The present invention also provides an efficacy-promoting composition comprising a polymer hyaluronic acid or its salt, a hydrolyzed hyaluronic acid or its salt, an acetylated hyaluronic acid or its salt, a tetrahydropyrimidine or its derivative, ergothioneine, Saccharomyces / Rice Fermentation Liquid , aminobutyric acid, a preservative and water. The mass ratio of each component and properties such as the molecular weight are as described above.

[0025] The present invention also provides the use of the above composition in skin care products or cosmetics.

[0026] The efficacy-promoting composition of the present invention contains a polymer hyaluronic acid, a hydrolyzed hyaluronic acid, an acetylated hyaluronic acid, a tetrahydropyrimidine, ergothioneine, Saccharomyces / Rice Fermentation Liquid and aminobutyric acid in a specific blending ratio, and thus has an effective efficacy-promoting function. For example, it can significantly promote moisture replenishment, improve the stability of active ingredients, and improve the absorption of anti-aging ingredients. This is because acetylated hyaluronic acid links a polymer hyaluronic acid of a specific molecular weight and a hydrolyzed hyaluronic acid in a specific blending ratio to construct a stable "I"-shaped channel in three-dimensional space, while tetrahydropyrimidine, ergothioneine, Saccharomyces / Rice Fermentation Liquid , and the four synergistic effects of aminobutyric acid ensure the efficient operation of the "I"-shaped structure formed by sodium hyaluronate and its derivatives. Examples

[0027] Hereinafter, the present invention will be further described with reference to examples, but it should be understood that the examples are only used to further illustrate the present invention and are not used to limit the present invention.

[0028] The experimental methods used in the following examples are conventional methods unless otherwise specified. The materials, reagents, etc. used in the following examples can be commercially obtained unless otherwise specified. Among them, sodium hyaluronate with high molecular weight, sodium hydrolyzed hyaluronate, sodium acetylated hyaluronate, Ectoine , ergothioneine, Saccharomyces / Rice Fermentation Liquid and aminobutyric acid are both sourced from Bloomage Biotechnology Corporation Limited.

[0029] Example 1 2.5g of high molecular weight sodium hyaluronate (1200kDa) was added to an appropriate amount of water and stirred until completely dissolved. Then, 2.5g of hydrolyzed sodium hyaluronate (5kDa) and 1g of acetylated sodium hyaluronate (molecular weight 4kDa, acetyl content 24%) were added and stirred uniformly until completely dissolved. Ectoine 3g, ergothioneine 7g, Saccharomyces / Rice Fermentation Liquid 20 g, 1.5 g of aminobutyric acid, and 5 g of preservatives (2.5 g of pentanediol, 2.5 g of hexanediol) were added in that order, water was added up to 100 g, and the mixture was stirred uniformly until completely dissolved to obtain an efficacy-enhancing composition.

[0030] In comparison with Example 1, in Examples 2 to 13 and Comparative Examples 1 to 8, as shown in Table 1, the molecular weight or content of high molecular weight sodium hyaluronate, hydrolyzed sodium hyaluronate, and acetylated sodium hyaluronate, Ectoine , ergothioneine, Saccharomyces / Rice Fermentation Liquid , and aminobutyric acid content are different. Among them, the difference between Example 9 and Example 1 is only the difference in molecular weight of high molecular weight sodium hyaluronate, the difference between Example 10 and Example 1 is only the difference in the content of high molecular weight sodium hyaluronate, the difference between Example 11 and Example 1 is only the difference in the content of hydrolyzed sodium hyaluronate, the difference between Example 12 and Example 1 is only the difference in molecular weight of hydrolyzed sodium hyaluronate, and the difference between Example 13 and Example 1 is the difference in the content of acetylated sodium hyaluronate.

[0031] [Table 1]

[0032] Test Example 1: Hydration effect 1. The skin moisture content was measured in 22 different areas of the forearm (area numbers 1 to 22) and the initial value data was recorded. 2. 1% by mass of ceramide-3 was added to each of the efficacy-promoting compositions produced in Examples 1 to 13 and Comparative Examples 1 to 8 to obtain hydration compositions corresponding to Examples 1 to 13 and Comparative Examples 1 to 8. 3. The same amount of hydrating compositions corresponding to Examples 1-13 and Comparative Examples 1-8 was applied to 21 different regions (region numbers 1-21) of the forearm, and after 30 minutes, the skin moisture content was measured and recorded using a skin moisture loss measuring device Tewameter TM300 (Courage+Khazaka, Germany). Among these, the hydrating composition of Example 1 corresponds to region 1, the hydrating composition of Example 2 corresponds to region 2, and thus the hydrating composition of Example 8 corresponds to region 8, the hydrating composition of Comparative Example 1 corresponds to region 14, the hydrating composition of Comparative Example 2 corresponds to region 15, and the hydrating composition of Comparative Example 8 corresponds to region 21. 4. The same amount of hydrating ingredient solution (1% by weight of ceramide-3) was applied to area 22 as a control, and after 30 minutes, the skin moisture content was measured and recorded. 5. The number of subjects was 10, and the moisture content was the average value.

[0033] The hydrating effect of each of the above hydrating compositions is shown in Table 2.

[0034] [Table 2]

[0035] Conclusion: From Table 2, it can be seen that the addition of the compositions prepared in the examples of the present invention significantly increases the hydrating ability of the hydrating ingredients, and in particular, the hydrating effect of the compositions obtained in Examples 1 to 4 is the highest, indicating that the efficacy-promoting composition of the present invention can effectively promote hydration. In Comparative Examples 1 to 3, since only two of the three hyaluronic acids are contained, the moisturizing effect is low. This is because the three hyaluronic acids of the present invention construct a stable "H" - shaped channel in three - dimensional space, forming a continuous moisturizing and water - replenishing channel from the moisturizing and water - retaining layer on the skin surface to the deep - layer water - replenishing layer of the skin, effectively replenishing water, increasing the water content of the skin. At the same time, the "H" - shaped channel increases the transdermal absorption effect of ceramide - 3, increases the utilization rate of ceramide - 3, and can enhance the moisturizing effect.

[0036] Comparative Examples 4 to 8 also have a low moisturizing effect. Among them, the moisturizing effect of Comparative Example 8 is the lowest, and the difference in skin water content before and after use is only 0.21. This is considered to be because the synergistic effect of tetrahydropyrimidine, ergothioneine, Saccharomyces / Rice Fermentation Liquid , and aminobutyric acid can maintain the stability and persistence of the film formed by high - molecular hyaluronic acid on the skin surface, ensuring the efficient operation of the "H" - shaped structure formed by sodium hyaluronate and its derivatives.

[0037] Test Example 2 Protective effect on active ingredients Astaxanthin was added to the efficacy - promoting compositions produced in Examples 1 to 13 and Comparative Examples 1 to 8 so that the mass percentage of astaxanthin in the composition was 0.01%, and astaxanthin - containing compositions corresponding to Application Examples 1 to 16 were obtained respectively. Here, the astaxanthin composition obtained in Example 1 corresponds to Application Example 1, the astaxanthin composition obtained in Example 2 corresponds to Application Example 2, and so on. The astaxanthin composition obtained in Example 8 corresponds to Application Example 8, the astaxanthin composition obtained in Example 13 corresponds to Application Example 13, the astaxanthin composition obtained in Comparative Example 1 corresponds to Application Example 14, the astaxanthin composition obtained in Comparative Example 2 corresponds to Application Example 15, and the astaxanthin composition obtained in Comparative Example 8 corresponds to Application Example 21.

[0038] The astaxanthin compositions of Application Examples 1 to 21 were placed in a transparent container and left at room temperature for 2 hours, during which time they were constantly stirred to expose them to oxygen, and the color change of the composition was observed. An appropriate amount of the composition was taken and diluted with trichloromethane solvent to a solution with a concentration of 1 μg / mL, and the absorbance at 489 nm was measured using a UV8500 ultraviolet spectrophotometer. Astaxanthin stored in a light-shielded sealed container at the same concentration was used as a control, and the absorbance at 489 nm was measured under the same conditions. The results are shown in Table 3.

[0039] [Table 3]

[0040] Conclusion: Astaxanthin is easily oxidized and becomes lighter in color, and the lighter the color, the more easily astaxanthin is oxidized, which indicates poor efficacy of astaxanthin. When the composition prepared in the examples of the present invention is added, the fading of the color of astaxanthin becomes less noticeable, and in particular, in Examples 1 to 4, the color change is the smallest, and the absorbance decreases by only 0.0391 to 0.0969 compared to the control stored in a sealed, light-shielded condition. However, in the comparative example, the color change of the astaxanthin composition was large, and the absorbance decreased by 0.3 or more. This shows that the efficacy promotion system constructed by the seven kinds of components of the present invention can increase the stability of macromolecular efficacy ingredients such as astaxanthin, increase the contact time of astaxanthin with the skin, and thereby increase the utilization rate of astaxanthin.

[0041] Test Example 3: Promoting effect of anti-aging ingredients 1. The wrinkles around the eyes and face were photographed with a Visia and skin age data was recorded. 2. By adding 1% of an anti-wrinkle component (anti-wrinkle complex peptide) to Example 1, Comparative Example 1, and Comparative Example 8, compositions having anti-aging effects corresponding to Application Examples 22, 23, and 24, respectively, were obtained. 3. Application examples 22, 23, and 24 were applied twice daily for 12 weeks on each area, and photos were taken with Visia every two weeks to record the skin age data. 4. The number of subjects was 10 for each group, and the skin age was the average value.

[0042] [Table 4]

[0043] Conclusion: The efficacy-promoting compositions prepared in the examples of the present invention can effectively promote the efficacy of anti-aging ingredients. As can be seen from the above table, in Application Example 22, the efficacy of the anti-aging ingredients increased significantly, and after a certain period of use, the skin age decreased by 6 years, while in Application Examples 23 and 24, the change in skin age after a certain period of use was relatively small or almost unchanged.

Claims

1. An efficacy enhancing composition comprising polymeric hyaluronic acid or a salt thereof, hydrolyzed hyaluronic acid or a salt thereof, acetylated hyaluronic acid or a salt thereof, tetrahydropyrimidine or a derivative thereof, ergothioneine, Saccharomyces / Rice Ferment Filtrate, and aminobutyric acid; the polymeric hyaluronic acid or a salt thereof is 1 to 30% by mass, the hydrolyzed hyaluronic acid or a salt thereof is 2 to 50% by mass, the acetylated hyaluronic acid or a salt thereof is 1 to 10% by mass, the tetrahydropyrimidine or a derivative thereof is 0.1 to 10% by mass, the ergothioneine is 2 to 20% by mass, the Saccharomyces / rice fermentation broth is 10 to 50% by mass, and the aminobutyric acid is 0.1 to 5% by mass; The molecular weight of the high molecular weight hyaluronic acid or its salt is 1000 to 1800 kDa; and The molecular weight of the hydrolyzed hyaluronic acid or its salt is 1 to 10 kDa; composition.

2. The composition according to claim 1, wherein the polymeric hyaluronic acid or a salt thereof is 1 to 10% by mass, the hydrolyzed hyaluronic acid or a salt thereof is 2 to 10% by mass, the acetylated hyaluronic acid or a salt thereof is 1 to 1.5% by mass, the tetrahydropyrimidine or a derivative thereof is 0.3 to 5% by mass, the ergothioneine is 3 to 10% by mass, the Saccharomyces / rice fermentation liquor is 15 to 40% by mass, and the aminobutyric acid is 0.3 to 3% by mass.

3. The composition according to claim 1 or 2, characterized in that, on a weight part basis, the polymeric hyaluronic acid or its salt is 1 part by weight, the hydrolyzed hyaluronic acid or its salt is 0.2 to 2 parts by weight, and the acetylated hyaluronic acid or its salt is 0.05 to 1.5 parts by weight.

4. The composition described in claim 3, characterized in that, on a part by weight basis, the polymeric hyaluronic acid or salt thereof is 1 part by weight, the hydrolyzed hyaluronic acid or salt thereof is 0.5 to 1 part by weight, and the acetylated hyaluronic acid or salt thereof is 0.1 to 0.5 parts by weight.

5. The composition according to any one of claims 1 to 4, characterized in that the molecular weight of the high molecular weight hyaluronic acid or its salt is 1000 to 1500 kDa.

6. The composition according to any one of claims 1 to 5, characterized in that the molecular weight of the hydrolyzed hyaluronic acid or its salt is between 5 kDa and 10 kDa.

7. The composition according to any one of claims 1 to 6, characterized in that the molecular weight of the acetylated hyaluronic acid or its salt is 20 kDa to 100 kDa and the acetyl group is 20 to 40 mass %.

8. The composition according to any one of claims 1 to 7, wherein the tetrahydropyrimidine or a derivative thereof is one or two selected from ectoine and hydroxyectoine.

9. The composition according to claim 8, wherein the tetrahydropyrimidine or derivative thereof is ectoine.

10. The composition according to any one of claims 1 to 9, further comprising a preservative, wherein the preservative in the composition is 0.1 to 5% by mass and is one or more preservatives selected from pentylene glycol, hexylene glycol, butylene glycol, and ethylhexylglycerin.

11. Use of the composition according to any one of claims 1 to 10 in skin care or cosmetic products.

12. A skin care product or cosmetic comprising the composition according to any one of claims 1 to 10.

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