Oral composition

Abstract

To provide a composition for an oral cavity that includes a water-soluble polymer and a wetting agent and gives a sense of mildness during use and has satisfactory lathering properties but is reduced in sticky feeling after use, to exhibit a refreshing feeling of use.SOLUTION: The present invention provides a composition for an oral cavity comprising (A) a wetting agent, such as a sugar alcohol, a di- or tri-hydric alcohol, or polyglycerin, (B) a water-soluble polymer, such as a polysaccharide or an acrylic-acid-based polymer, and (C) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an oral composition. [Background technology]

[0002] By blending a humectant or a water-soluble polymer into an oral composition, it is possible to impart a smooth feeling during use (for example, Patent Documents 1 and 2). In dentifrice, blending a water-soluble polymer also has the advantage of improving foaming properties. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Publication No. 5-194165 [Patent Document 2] JP 2020-83831 A Summary of the Invention [Problem to be solved by the invention]

[0004] However, these components may cause an unpleasant feeling after use, such as stickiness after ejection of a liquid oral composition or after rinsing of a semi-solid or solid oral composition. The present invention aims to provide an oral composition that contains a water-soluble polymer and a humectant, has a smooth feel during use, and exhibits good foaming properties while suppressing stickiness after use, allowing for a refreshing feeling after use. [Means for solving the problem]

[0005] That is, the present invention provides the following [1] to [8]. [1] (A) a wetting agent, (B) a water-soluble polymer, and (C) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide The oral composition is a liquid comprising: [2] The composition according to [1], which satisfies at least one of the following: The content of component (A) is 1 to 50 mass%; The content of component (B) is 0.01 to 1% by mass; and The content of the component (C) is 0.00001 to 0.1 mass %. [3] The oral composition according to [1] or [2], which is a mouthwash or mouth spray. [4] (A) a wetting agent, (B) Water-soluble polymer (C) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide Contains The content of component (A) is 25 to 70 mass %, An oral composition which is non-liquid. [5] The oral composition according to [4], which satisfies at least one of the following: The content of the (B) component is 0.1 to 3 mass%; and The content of the component (C) is 0.00001 to 0.1 mass %. [6] The oral composition according to [4] or [5], which is a toothpaste, a gel toothpaste, a powder toothpaste, a sheet toothpaste, or a solid toothpaste. [7] The oral composition according to any one of [1] to [6], wherein the component (A) is one or more selected from the group consisting of sugar alcohols, dihydric to trihydric polyhydric alcohols, and polyglycerols. [8] The oral composition according to any one of [1] to [7], wherein the component (B) is one or more selected from the group consisting of polysaccharides, polyglutamic acid or a salt thereof, and acrylic acid-based polymers. Effect of the Invention

[0006] According to the present invention, there is provided an oral composition which has a smooth feel during use, good foaming properties, and reduced stickiness after use, providing a refreshing feel when used. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0007] The present invention will be described in detail below.

[0008] [Dosage form of oral composition] The oral composition of the present invention is a liquid oral composition or a non-liquid oral composition. In this specification, the liquid oral composition refers to an oral composition that is liquid at room temperature (20°C), and examples of such compositions include mouthwash, mouth spray (spray), liquid dentifrice, foam dentifrice, and liquid coating agents, with mouthwash and mouth spray being preferred. In this specification, the non-liquid oral composition refers to an oral composition other than a liquid oral composition (non-liquid), and is usually a semi-solid or solid (e.g., paste, gel, granule, tablet) that has shape retention at room temperature. Examples of non-liquid oral compositions include dentifrices other than liquid dentifrice (e.g., toothpaste, lubricant, gel dentifrice, etc.), non-liquid coating agents (ointments, etc.), patches, oral dissolving agents (tablets, films, etc.), and oral disintegrating agents (tablets, etc.).

[0009] The oral cavity composition of the present invention contains the following components (A) to (C).

[0010] [Component (A)] Component (A) is a humectant. By including component (A), it is possible to achieve a smooth feeling during use.

[0011] Examples of the humectant include sugar alcohols and polyhydric alcohols other than sugar alcohols, and sugar alcohols, dihydric to trihydric polyhydric alcohols, diglycerin, and polyglycerin are preferred. Examples of the sugar alcohol include sorbitol, xylitol, erythritol, mannitol, reduced starch saccharification products, maltitol, and lactitol. Examples of the dihydric to trihydric polyhydric alcohol include propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, octylene glycol, ethylene glycol, glycerin, and polyethylene glycol. The average degree of polymerization of polyethylene glycol is usually 200 to 1500, preferably 200 to 1000. Examples of the polyethylene glycol include polyethylene glycol 200, polyethylene glycol 300, polyethylene glycol 400, polyethylene glycol 600, and polyethylene glycol 1000. The average degree of polymerization of polyglycerin is usually 3 to 20, preferably 3 to 10. Examples of polyglycerin include polyglycerin-3, polyglycerin-4, polyglycerin-6, and polyglycerin-10. In this specification, the average molecular weight of polyethylene glycol is usually the average molecular weight described in the Quasi-Drug Raw Materials Standards 2006. In addition, the average degree of polymerization of polyglycerin is usually the degree of polymerization calculated from the hydroxyl value according to the following formula (1). [Formula (1)] Average degree of polymerization = (112.2 x 103 - 18 x hydroxyl value) / (74 x hydroxyl value - 56.1 x 103) The hydroxyl value in formula (1) can be measured in accordance with the "Standard Testing Methods for the Analysis of Fats, Oils and Related Compounds" (established by the Japan Oil Chemists' Society). The component (A) may be a single wetting agent or a combination of two or more wetting agents.

[0012] The content of the (A) component is preferably 1% by mass or more in the case of a liquid dosage form, and 25% by mass or more in the case of a non-liquid dosage form, based on the entire oral composition (100% by mass). This allows a smoother feel during use. The upper limit is preferably 50% by mass or less in the case of a liquid dosage form, more preferably 40% by mass or less, and particularly preferably 20% by mass or less. In the case of a non-liquid dosage form, it is preferably 70% by mass or less, and more preferably 60% by mass or less. This allows the reduction in flavor expression due to stickiness to be suppressed. Therefore, the content of the (A) component is preferably 25 to 70% by mass, more preferably 25 to 60% by mass in the case of a non-liquid dosage form, and preferably 1 to 50% by mass, more preferably 1 to 40% by mass, and particularly preferably 1 to 20% by mass in the case of a liquid dosage form.

[0013] [(B) Component] Component (B) is a water-soluble polymer. By including component (B), it is possible to achieve a smooth sensation during use. In addition, in the case of a non-liquid dosage form, the amount of foam can be adjusted to an appropriate level.

[0014] Examples of water-soluble polymers include polysaccharides, polyglutamic acid or its salts, and acrylic acid polymers. Examples of polysaccharides include alginic acid or its esters or salts, carrageenan, guar gum, xanthan gum, tragacanth gum, karaya gum, arabic gum, locust bean gum, gelatin, gellan gum, hyaluronic acid or its salts, water-soluble cellulose derivatives (e.g., carboxymethyl cellulose (CMC), methyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, hydroxymethyl ethyl cellulose, hydroxypropyl cellulose, cationic cellulose), and propylene glycol alginate. Examples of acrylic acid polymers include polyacrylates, carboxyvinyl polymers, and acrylic acid-alkyl methacrylate copolymers. Examples of other water-soluble polymers include polyvinyl alcohol and polyvinylpyrrolidone. Among these, polysaccharides, polyglutamic acid or its salts, and acrylic acid polymers are preferred. Examples of the above salts include alkali metal salts, and preferably sodium salts. An example of the alginate ester is propylene glycol alginate. The component (B) may be a single water-soluble polymer, or a combination of two or more water-soluble polymers.

[0015] The content of the (B) component is usually 0.01% by mass or more, preferably 0.1% by mass or more, based on the entire liquid or non-liquid oral composition (100% by mass). This allows for a more mellow feel during use. Furthermore, in the case of a non-liquid dosage form, it is more preferably 0.5% by mass or more. This allows for a more appropriate amount of foam in the case of a non-liquid dosage form (e.g., a dentifrice dosage form). The upper limit is usually 3% by mass or less, based on the entire oral composition (100% by mass), more preferably 2.5% by mass or less, based on the entire oral composition (100% by mass), and in the case of a non-liquid dosage form, it is preferably 1% by mass or less, more preferably 0.5% by mass or less, based on the entire oral composition (100% by mass). This allows for a reduction in flavor expression due to stickiness. Therefore, the content of component (B) is usually 0.01 to 3 mass% of the entire oral composition (100 mass%), and in the case of a non-liquid dosage form, it is preferably 0.1 to 3 mass%, more preferably 0.5 to 2.5 mass%, and in the case of a liquid dosage form, it is preferably 0.01 to 1 mass%, more preferably 0.1 to 0.5 mass%.

[0016] [(C) component] The component (C) is N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide. By including the component (C), the stickiness after use can be improved and a refreshing feeling can be obtained.

[0017] The content of the (C) component is preferably 0.00001% by mass or more, more preferably 0.00005% by mass or more, based on the entire oral composition (100% by mass). This provides a better effect of improving stickiness. The upper limit is preferably 0.1% by mass or less, more preferably 0.005% by mass or less. This can prevent the aftertaste from becoming too strong due to excessive irritation. Therefore, the content of the (C) component is preferably 0.00001 to 0.1% by mass, more preferably 0.00005 to 0.005% by mass.

[0018] [Optional ingredients] The oral cavity composition may contain optional components other than the components (A) to (C) already explained, so long as the effects of the present invention are not impaired.

[0019] Examples of optional components include abrasives, surfactants, sweeteners, flavorings, medicinal components, oily components, abrasives, preservatives, wetting agents, binders, pH adjusters, colorants (pigments), and solvents. These will be described in detail below.

[0020] -Abrasives- The abrasive may be either an inorganic abrasive or an organic abrasive. Examples of inorganic abrasives include silica-based abrasives such as anhydrous silicic acid, crystalline silica, amorphous silica, silica gel, aluminosilicate, zirconosilicate, zeolite, precipitated silica, and titanium-bonded silica; calcium phosphates such as calcium hydrogen phosphate anhydrate, calcium hydrogen phosphate dihydrate, calcium monophosphate, calcium triphosphate, calcium pyrophosphate, insoluble calcium metaphosphate, calcium triphosphate, calcium tetraphosphate, and calcium octylphosphate; calcium carbonate (light and heavy), calcium hydroxide, and calcium sulfate; sodium bicarbonate; aluminum-based abrasives such as aluminum hydroxide, aluminum oxide, and alumina; magnesium carbonate, magnesium salt of magnesium triphosphate; apatites such as hydroxyapatite, fluoroapatite, and calcium-deficient apatite; bentonite; and titanium dioxide. Examples of organic abrasives include synthetic resin-based abrasives and polymethyl methacrylate. Among these, inorganic abrasives are preferred, silica-based abrasives and aluminum-based abrasives are more preferred, and silicic anhydride and aluminum oxide are even more preferred. The content of the abrasive is generally 70% by mass or less, preferably 50% by mass or less, and more preferably 8 to 50% by mass, based on the entire dentifrice oral composition (100% by mass).

[0021] -Surfactants- Examples of the surfactant include anionic surfactants, nonionic surfactants, and amphoteric surfactants.

[0022] Examples of anionic surfactants include alkyl sulfates, acyl amino acid salts, acyltaurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, and lauryl sulfoacetates. The alkyl group and acyl group may be either linear or branched, and may be either saturated or unsaturated, and the number of carbon atoms is usually 10 to 20, preferably 12 to 18, and more preferably 12 to 14. The salt may be selected from pharmacologically acceptable salts. Examples of pharmacologically acceptable salts include base addition salts and amino acid salts. Specific examples of such salts include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and basic amino acid salts such as arginine salts. Among them, inorganic base salts are preferred, alkali metal salts (e.g., sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

[0023] Examples of alkyl sulfates include lauryl sulfate (sodium lauryl sulfate) and myristoyl sulfate. Examples of acylamino acid salts include acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; acyl glutamate salts such as lauroyl glutamate, myristoyl glutamate, palmitoyl glutamate; acyl glycine salts such as N-lauroyl-N-methyl glycine salt and cocoyl glycine salt; acyl alanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt, N-methyl-N-acylalanine salt; and acyl aspartate salts such as lauroyl aspartate. Examples of acyltaurate salts include lauroyl methyl taurate, N-methyl-N-acyltaurate salt, and N-cocoyl methyl taurate salt. Examples of α-olefin sulfonate salts include α-olefin sulfonate salts having 12 to 18 carbon atoms, such as tetradecene sulfonate salt. Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride sodium monosulfate and sodium lauryl sulfoacetate.

[0024] From the viewpoint of foaming ability and foam quality, the anionic surfactant preferably contains a sulfonic acid group, and more preferably is an alkyl sulfate or an α-olefin sulfonate.

[0025] Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, glycerin fatty acid esters, sucrose fatty acid esters (e.g., maltose fatty acid esters), sugar alcohol fatty acid esters (e.g., maltitol fatty acid esters, lactitol fatty acid esters), fatty acid diethanolamides (e.g., lauric acid mono- or diethanolamide), polyoxyethylene polyoxypropylene copolymers, and polyoxyethylene polyoxypropylene fatty acid esters. The number of carbon atoms in the alkyl chain of the polyoxyethylene alkyl ether is usually 14 to 18, and the average number of moles of ethylene oxide added is usually 5 to 30 moles. The average number of moles of ethylene oxide added in the polyoxyethylene hydrogenated castor oil is usually 20 to 100 moles, preferably 20 to 60 moles. The number of carbon atoms in the fatty acid of the sorbitan fatty acid ester is usually 12 to 18. The number of carbon atoms in the fatty acid of the polyoxyethylene sorbitan fatty acid ester is usually 16 to 18, and the average number of moles of ethylene oxide added is usually 10 to 40. The number of carbon atoms in the alkyl chain of the alkylolamide is usually 12 to 14. As the nonionic surfactant, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, and polyoxyethylene alkyl ether are preferred.

[0026] Examples of amphoteric surfactants include betaine-type amphoteric surfactants such as alkyl dimethylaminoacetate betaine (e.g., lauryl dimethylaminoacetate betaine) and fatty acid amidopropyl dimethylaminoacetate betaine (e.g., cocamidopropyl betaine); imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salts (e.g., N-coconut fatty acid acyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine), coconut fatty acid imidazolinium betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine; and alkyl betaines such as lauryl dimethylaminoacetate betaine.

[0027] The content of the surfactant is preferably 0.1 to 5 mass %, more preferably 0.5 to 3 mass %, based on the entire oral cavity composition (100 mass %).

[0028] -Medicinal ingredients- Examples of medicinal ingredients include bactericidal or antibacterial agents such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, isopropylmethylphenol, zinc gluconate, zinc citrate, triclosan, thymol, hinokitiol, and lysozyme chloride; enzymes such as dextranase, mutanase, amylase, protease, and Liteque Enzyme; fluorides such as sodium fluoride, sodium monofluorophosphate, and tin fluoride; ε-aminocaproic acid, allantoin, tranexamic acid, allantoin chlorohydroxyaluminum, azulene, dihydrocholesterol glycyrrhizinate (e.g., dipotassium glycyrrhizinate), glycyrrhetinic acid, and glycyrrhetinic acid derivatives (e.g., glycyrrhetinic acid derivatives, glycyrrhetinic acid derivatives, and glycyrrhetinic acid derivatives). Examples of the medicinal ingredients include anti-inflammatory agents such as stearyl tinate; metal salts such as zinc salts, copper salts, and tin salts; condensed phosphates, ethanehydroxydiphosphonate, and other dental calculus prevention agents; blood flow promoters such as vitamin E (e.g., tocopherol acetate); hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; coating agents such as hydroxyethylcellulose dimethyl diallyl ammonium chloride; astringents such as vitamin C (e.g., ascorbic acid or its salts), and lysozyme chloride; water-soluble copper compounds such as copper chlorophyll and copper gluconate; dental calculus prevention agents; amino acids such as alanine, glycine, and proline; plant extracts such as thyme, Scutellaria baicalensis, clove, and witch hazel; callopeptide, and polyvinylpyrrolidone. The medicinal ingredients may be used alone or in combination of two or more. The content of the medicinal ingredients can be appropriately set to an effective amount according to a conventional method.

[0029] -Fragrance- The composition contains a fragrance, which can improve the feeling of use. Examples of the fragrance include peppermint oil, spearmint oil, Japanese peppermint oil, anise oil, cassia oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange flower oil), lemongrass oil, jasmine oil, rose oil, iris oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, laurel oil, chamomile oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, lime oil, grapefruit oil, mandarin oil, yuzu oil, nutmeg oil, lavender oil, parakress oil, vanilla oil, Natural essential oils such as cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, wintergreen oil, and coriander oil; menthol, carvone, cinnamic aldehyde, p-methoxycinnamic aldehyde, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, spilanthol, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineole, ethyl linalool, wa Fragrance components contained in the above natural essential oils such as ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, cis-3-hexenol, trans-2-hexenal, methyl anthranilate, ethyl methylphenylglycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, menthofuran, undecalactone, decalactone, linalool oxide, vanillyl butyl ether, hexyl acetate, ethyl-2-methylbutyrate, benzyl alcohol, linalyl Fragrance ingredients such as acetate, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, octanol, methyl cinnamate, methyl heptine carbonate, ionone, ethyl-β-methylthiopropionate, cis-6-nonenol, carone, methyl jasmonate, maltol, ethyl maltol, furaneol, ethyl cyclopentenolone, 3-hydroxy-4,5-dimethylfuran-2-one, cyclotene, 2-methylbutyric acid, acetic acid, and propionic acid;Examples of the flavors include various blended flavors such as mint, fruit, and herb flavors that are made by combining plant extracts such as chili pepper extract, ginger extract, and pepper extract, and several flavor components and natural essential oils. As the flavor, the above-exemplified flavors may be used alone or in combination of two or more.

[0030] -Sweetener- The composition contains a sweetener, which can improve the feeling of use. Examples of sweeteners include saccharin, saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine, glycyrrhizin, thaumatin, aspartyl phenylalanine methyl ester, etc. As the sweetener, the above-mentioned sweeteners may be used alone or in combination of two or more.

[0031] -Oily ingredients- Examples of oily components include hydrocarbons such as squalane, liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols having 8 to 22 carbon atoms such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids having 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, and isostearic acid), vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate.

[0032] -Preservatives- The composition contains a preservative, thereby ensuring the preservative power of the preparation. Examples of the preservative include paraoxybenzoic acid esters (e.g., methyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate), sodium benzoate, etc. The preservative may be used alone or in combination of two or more.

[0033] -Binding agent- By including an optional binder in the composition, the viscosity can be optimized, and the shape retention and usability can be further improved. The optional binder includes binders other than water-soluble polymers, for example, inorganic binders such as thickening silica, aluminum silicate, and montmorillonite. The content of the optional binder is preferably 0 to 10% by mass, more preferably 1 to 8% by mass, based on the entire oral composition (100% by mass).

[0034] -pH adjuster- The composition contains a pH adjuster, which can ensure the pH stability of the formulation. Examples of the pH adjuster include organic acids such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, and lactic acid, or their salts (sodium citrate), inorganic acids such as phosphoric acid (orthophosphoric acid), or their salts (e.g., potassium salts, sodium salts, and ammonium salts), and hydroxides such as sodium hydroxide and potassium hydroxide.

[0035] The content of the pH adjuster can usually be an amount such that the pH of the oral composition after addition is 5 to 9, preferably 6 to 8.5.

[0036] In this specification, the pH value generally refers to the value 3 minutes after the start of measurement at 25° C. The pH value can be measured, for example, using a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd.

[0037] -Coloring agent- Examples of colorants include natural colorants such as safflower red colorant, gardenia yellow colorant, gardenia blue colorant, perilla colorant, red koji colorant, red cabbage colorant, carrot colorant, hibiscus colorant, cacao colorant, spirulina blue colorant, and tamarind colorant, legal colorants such as Red No. 2, Red No. 3, Red No. 104, Red No. 105, Red No. 106, Red No. 227, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1, riboflavin, sodium copper chlorophyte, and titanium dioxide. When the oral composition contains a colorant, the content thereof is preferably 0.00001 to 3% by mass of the entire oral composition.

[0038] -solvent- Examples of the solvent include water (purified water) and ethanol. The solvent may be used alone or in combination of two or more. The content of the solvent is usually 1 to 90% by mass, preferably 15 to 80% by mass, more preferably 20 to 60% by mass, based on the total amount of the composition, and can be appropriately determined depending on whether the composition is liquid or non-liquid. In the case of a mixed solvent, the amount of ethanol added is usually 1 to 30% by mass, preferably 1 to 20% by mass, based on the total amount of the composition.

[0039] -Other optional ingredients- Examples of optional components other than those mentioned above include polyisobutylene, polybutadiene, urethane, silicone, and natural rubber. The content of these optional components can be appropriately set within a range that does not impair the effects of the present invention.

[0040] [Method of producing the composition] The method for producing the oral composition is not particularly limited, and the composition can be prepared by any conventional method depending on the dosage form. The method for producing the liquid oral composition includes a method of sequentially adding raw material components to a solvent such as purified water, stirring, and dissolving uniformly. After preparation, it can be stored in a container such as PET (polyethylene terephthalate), glass, polypropylene, or polyethylene. From the viewpoint of suppressing the adsorption of fragrance, the container is preferably a PET or glass container. As a method for producing a non-liquid oral composition such as toothpaste, a method is available in which the components that dissolve in a solvent are prepared, and then the other insoluble components are mixed, and degassing (e.g., reduced pressure, etc.) is performed as necessary. The obtained toothpaste can be placed in a container to make a product. The shape and material of the container are not particularly limited, and containers used for ordinary toothpaste compositions can be used, for example, containers such as laminated tubes made of plastics such as polyethylene, polypropylene, polyethylene terephthalate, and nylon. EXAMPLES

[0041] The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In each example, % is mass percentage.

[0042] Examples 1-1 to 1-26 and Comparative Examples 1-1 to 1-4 (Mouthwash), and Examples 2-1 to 2-25 and Comparative Examples 2-1 to 2-4 (Toothpaste) Oral compositions having the compositions shown in Tables 1 to 9 (Tables 1 to 5: mouthwashes; Tables 6 to 9: toothpastes) were prepared by conventional methods. The toothpastes were contained in ordinary oral preparation containers (laminated tubes). These were used as samples and evaluated by the methods shown below. The results are shown in Tables 1 to 9.

[0043] [Ingredients used] -(A) Component- Sorbitol solution (70%): (Mitsubishi Corporation Life Sciences Co., Ltd.) Propylene glycol: (ADEKA Corporation) Glycerin: (manufactured by Sakamoto Pharmaceutical Co., Ltd.) Polyethylene glycol: (Sanyo Chemical Industries, Ltd., Polyethylene glycol 400) 1,3-Butylene glycol: (Kyukyu Alcohol Kogyo Co., Ltd.)

[0044] -(B) Component- Xanthan gum: (DSP Gokyo Food & Chemical Co., Ltd.) Sodium polyacrylate: (manufactured by Toagosei Co., Ltd., Rheogic (registered trademark) 250H) Sodium carboxymethylcellulose: (Daicel FineChem Co., Ltd., CMC1260) Carrageenan: (CP Kelco Japan Co., Ltd.) Sodium alginate: (Kimika Co., Ltd.) Sodium hyaluronate: (Hyaluronic acid HA-LQ, Hyaluronic acid HA-LQH, manufactured by Kewpie Corporation)

[0045] -(C) Ingredients and their substitutes- N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide: (manufactured by Takasago International Corporation, Coolact (registered trademark) 370) N-Ethyl-p-menthane-3-carboxamide: (WS-3, manufactured by Symrise Japan Co., Ltd.)

[0046] -Components other than components (A) to (C)- Citric acid: (Fuso Chemical Co., Ltd.) Sodium citrate: (Fuso Chemical Co., Ltd.) Sodium saccharin: (Aisan Chemical Industry Co., Ltd.) Viscosifying silica: (Carplex (registered trademark) #67, manufactured by DSL Japan Co., Ltd.) Abrasive Silica: (Tixosil® 73, Solvay) Sodium fluoride: (Stella Chemifa Co., Ltd.) Sodium lauryl sulfate: (BASF Japan Ltd.) Fragrance A: See below For ingredients other than those mentioned above, raw materials that comply with the 2006 Standards for Quasi-Drug Raw Materials were used.

[0047] [Method of evaluating mouthwash] After rinsing for 30 seconds, subjects were asked to evaluate the smoothness during use, stickiness after use, irritation after use, and flavor development on a 5-point scale according to the following criteria. The average score of the four subjects was calculated and expressed as ◎, ○, or × (smoothness during use was ◎, ○, △, or ×) according to the following criteria.

[0048] <Smoothness during use> Scoring criteria 5: Very sensitive 4: Feel 3: Somewhat 2: I don't feel much 1: Very little Evaluation criteria ◎: 4 points or more ○: 3 points or more and less than 4 points △: 2 points or more but less than 3 points ×: 1 point or more and less than 2 points

[0049] <Sticky after use> Scoring criteria 5: No feeling at all 4: Barely felt 3: Not much 2: Somewhat 1: Very sensitive Evaluation criteria ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points

[0050] <Good flavor expression> Scoring criteria 5: Very good 4: Good 3: Fairly good 2: Not very good 1: Not good Evaluation criteria ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points

[0051] <Irritation after use> Scoring criteria 5: No feeling at all 4: Barely felt 3: Not much 2: Somewhat 1: Very sensitive Evaluation criteria ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points

[0052] [Method of evaluating dentifrice compositions] One gram of the dentifrice composition was placed on a toothbrush (Clinica Advantage Toothbrush, 4-row compact normal type, manufactured by Lion Corporation), brushed in the usual manner, and rinsed once with water. The amount of foam during brushing, smoothness, stimulation, flavor expression, and the presence or absence of stickiness after rinsing were evaluated on a 5-point scale according to the following rating scale. The average scores of the four testers were calculated and shown in the table as ◎, ○, and × according to the following rating scale.

[0053] <Bubble amount> Scoring criteria 5: Very good 4: Good 3: Fairly good 2: Not very good 1: Not good Evaluation criteria ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points

[0054] <Smoothness during use> Scoring criteria 5: Very sensitive 4: Feel 3: Somewhat 2: I don't feel much 1: Very little Evaluation criteria ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points

[0055] <Sticky after use> Scoring criteria 5: No feeling at all 4: Barely felt 3: Not much 2: Somewhat 1: Very sensitive Evaluation criteria ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points

[0056] <Good flavor expression> Scoring criteria 5: Very good 4: Good 3: Fairly good 2: Not very good 1: Not good Evaluation criteria ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points

[0057] <Irritation after use> Scoring criteria 5: No feeling at all 4: Barely felt 3: Not much 2: Somewhat 1: Very sensitive Evaluation criteria ◎: 4 points or more ○: 3 points or more and less than 4 points ×: Less than 3 points

[0058] [Table 1]

[0059] [Table 2]

[0060] [Table 3]

[0061] [Table 4]

[0062] [Table 5]

[0063] [Table 6]

[0064] [Table 7]

[0065] [Table 8]

[0066] [Table 9]

[0067] [Table Footnotes] *The composition of fragrance A is as shown in the table below. Note that in the above examples, when any of fragrances B to H in the table was used instead of fragrance A below, the same results as above were obtained.

[0068] [Table 10]

[0069] [Table 11]

[0070] The compositions of Flavors 1 to 7 and the solvents in Tables 10 and 11 are shown below.

[0071] -Flavor 1- Mass part Linalool 1 Menthofuran 1 Anethole 1 Mentone 1 Menthyl Acetate 1 Total 5

[0072] -Flavor 2- Mass part Orange oil 1 Orange refined oil (80% front stream cut) 1 Lemon oil 1 pc Lemon refined oil (front stream 95% cut) 1 1 Lime Oil Grapefruit oil 1 Mandarin Oil 1 Yuzu oil 1 Citral 1 Decal 1 Total 10

[0073] -Flavor 3- Mass part Anise oil 1 Eucalyptus Oil 1 Cassia Oil 1 Clove oil 1 Thyme oil 1 1 sage oil Cardamom oil 1 Coriander oil 1 Rosemary oil 1 Laurel Oil 1 Chamomile oil 1 Caraway oil 1 Basil oil 1 Total 13

[0074] -Flavor 4- Mass part Wintergreen Oil 1 Mastic oil 1 Lavender oil 1 Neroli oil (orange flower oil) 1 Lemongrass Oil 1 Jasmine Oil 1 Rose oil 1 Iris oil 1 1 cup vanilla oil Total 9

[0075] -Flavor 5- Mass part Spilanthol 1 Linalool oxide 1 Vanillyl butyl ether 1 Capsicum extract 1 Ginger Extract 1 Pepper Extract 1 Total 6

[0076] -Flavor 6- Mass part Maltol 1 Ethyl Maltol 1 Vanillin 1 Ethyl vanillin 1 Furaneol 1 Ethylcyclopentenolone 1 3-Hydroxy-4,5-dimethylfuran-2-one 1 Cyclotene 1 2-Methylbutyric acid 1 Acetic Acid 1 Propionic Acid 1 Total 11

[0077] -Flavor 7- Mass part p-Methoxycinnamic aldehyde 1 cis-3-hexenol 1 Trans-2-Hexenal 1 Undecalactone 1 Decalactone 1 Ethyl Butyrate 1 Isoamyl acetate 1 Benzaldehyde 1 Hexyl Acetate 1 Ethyl 2-methylbutyrate 1 Benzyl alcohol 1 α-Terpineol 1 Linalyl Acetate 1 Phenylethyl glycidate 1 Phenylethyl alcohol 1 Allyl hexanoate 1 Octanol 1 Methyl cinnamate 1 Methylheptine carbonate 1 Yonon 1 Ethyl-β-methylthiopropionate 1 Cis-6-nonenol 1 Caron 1 Methyl jasmonate 1 Total 24

[0078] -solvent- Mass part Propylene glycol 1 Glycerol fatty acid ester 1 Triacetin 1 Ethanol 1 Total 4

[0079] The following can be seen from Tables 1 to 5 of the mouthwashes. Comparative Example 1-1, which does not contain the (A) component, was rated low in mellowness, and Comparative Example 1-2, which does not contain the (B) component, also had insufficient mellowness. On the other hand, Comparative Example 1-3, which does not contain the (C) component, and Comparative Example 1-4, which contains another cooling agent instead of the (C) component, were felt to be sticky after use. In contrast, Examples 1-1 to 1-26, which contain the (A) to (C) components, were well-balanced and rated good in terms of foam volume, mellowness, and stickiness, had good flavor expression, and suppressed irritation after use.

[0080] The following can be seen from Tables 6 to 9 of the dentifrices. Comparative Example 2-1, which does not contain component (A), was rated low in mellowness, Comparative Example 2-2, which does not contain component (B), had a small amount of foam, and Comparative Example 2-3, which does not contain component (C), and Comparative Example 2-4, which contains another cooling agent instead of component (C), were felt to be sticky after use. In contrast, Examples 2-1 to 2-25, which contain components (A) to (C), were rated well-balanced in terms of foam volume, mellowness, and stickiness, had a good flavor, and suppressed irritation after use.

[0081] These results show that the oral composition of the present invention can exhibit a mellow taste while suppressing a sticky feeling, and that in non-liquid oral compositions, it also has good foaming properties.

Claims

1. (A) a wetting agent, (B) a water-soluble polymer, and (C) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide; The component (A) is at least one selected from the group consisting of sugar alcohols, dihydric to trihydric polyhydric alcohols, and polyglycerols, The component (B) is at least one member selected from the group consisting of polyglutamic acid or a salt thereof, and an acrylic acid-based polymer; The content of the (A) component is 1 to 50 mass %, The content of the (B) component is 0.01 to 1 mass %, The content of the (C) component is 0.00001 to 0.1 mass %. An oral composition which is a liquid.

2. The oral composition according to claim 1 , which is a mouthwash or a mouth spray.

3. (A) a wetting agent, (B) Water-soluble polymer (C) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide Contains The component (A) is at least one selected from the group consisting of sugar alcohols, dihydric to trihydric polyhydric alcohols, and polyglycerols, The component (B) is at least one member selected from the group consisting of polyglutamic acid or a salt thereof, and an acrylic acid-based polymer; The content of the (A) component is 25 to 70 mass %, The content of the (B) component is 0.1 to 3 mass %, The content of the (C) component is 0.00001 to 0.1 mass %, An oral composition that is non-liquid.

4. 4. The oral composition according to claim 3, which is a toothpaste, a gel toothpaste, a powder toothpaste, a sheet toothpaste, or a solid toothpaste.

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