Skin preparations

Abstract

To provide a topical skin preparation that can effectively protect skin from various types of external stimulation such as air pollutant and acidic liquid.SOLUTION: A topical skin preparation contains hydroxy apatite and a polyamine. The polyamine is preferably at least one selected from the group consisting of spermine, putrescine, and spermidine, their acetylated bodies, and polymers of two or more of them and may be derived from soybean sprout extract. The topical skin preparation can serve as a sunscreen cosmetic.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an external preparation for skin. [Background technology]

[0002] Skin and hair are constantly exposed to external stimuli and are subject to various types of damage from the external environment. In particular, air pollutants such as fine particulate matter, which have recently attracted attention, and acidic liquids such as acid rain are known to have adverse effects on the skin when attached to the skin. In order to protect the skin from these external stimuli, it is possible to prevent substances that may cause damage from being attached to the skin and / or to alleviate the adverse effects of attached irritating substances (by preventing oxidation or neutralizing them).

[0003] Cosmetics that contain oily film-forming agents to tightly coat the skin have been proposed as so-called "anti-pollution cosmetics" that are cosmetics that have the above-mentioned function of protecting the skin. Although these are effective in preventing irritant substances from adhering to the skin, they feel unpleasant when used because they coat the skin with a tight film, and it has been unclear whether they are effective against all irritant substances.

[0004] Patent Document 1 describes a composition (cosmetic) for protecting the skin or hair from heavy metals contained in air pollutants, which is characterized by containing a chelating agent that chelates heavy metals and a sphingolipid. Patent Document 2 describes a skin and hair protective agent containing an extract of a plant of the genus Bletilla in the family Orchidaceae, which aims to mitigate the adverse effects of irritating substances by utilizing the antioxidant effect of the extract. Patent Document 3 describes an anti-pollution cosmetic composition containing magnesium aluminometasilicate as an active ingredient.

[0005] As described above, cosmetics and the like intended to protect the skin by capturing irritating substances such as air pollutants or by suppressing oxidation have been proposed, but their effectiveness has been limited. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] JP 2004-244423 A [Patent Document 2] JP 2004-262894 A [Patent Document 3] International Publication No. WO2014 / 136993 Summary of the Invention [Problem to be solved by the invention]

[0007] Therefore, an object of the present invention is to provide an external skin preparation that can effectively protect the skin from various external stimuli such as air pollutants and acidic liquids. [Means for solving the problem]

[0008] The present inventors have conducted extensive research into the above-mentioned problems and have completed the present invention. (1) A skin topical agent containing hydroxyapatite and polyamine. (2) The skin topical preparation according to (1), wherein the polyamine is one or more selected from the group consisting of spermine, putrescine, spermidine, acetylated forms thereof, and polymers of two or more of these. (3) The topical skin preparation according to (1) or (2), wherein the polyamine is derived from soybean germination extract. (4) The skin external preparation according to any one of (1) to (3), which is a sunscreen cosmetic. (5) The external skin preparation according to any one of (1) to (4), further comprising a spherical powder. (6) The external skin preparation according to any one of (1) to (5), wherein the spherical powder is a borosilicate. Effect of the Invention

[0009] The present invention provides an external skin preparation that can effectively protect the skin from various external stimuli such as air pollutants and acidic liquids. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] Hereinafter, an embodiment of the present invention will be described.

[0011] Hydroxyapatite is a type of apatite that mainly contains hydroxyl groups as monovalent anions, and is a major component of hard tissues such as the teeth and bones of vertebrates. Synthetic materials are often used as cosmetic raw materials, and there are various synthesis methods such as dry synthesis and wet synthesis, but any synthesis method can be used. Hydroxyapatite derived from natural products can also be used. Hydroxyapatite derived from natural products includes hydroxyapatite derived from pearl oyster shells and pearls, hydroxyapatite derived from fossil coral, and hydroxyapatite derived from scallop shells.

[0012] Commercially available examples of such hydroxyapatite include SP-1, spherical hydroxyapatite (all manufactured by Sangi Co., Ltd.), FL-HAP (manufactured by Taihei Chemical Industry Co., Ltd.), DN-HAP(SH) (manufactured by Dainippon Kasei Co., Ltd.), bioapatite (manufactured by Japan Barrier Free Co., Ltd.), and coral apatite (manufactured by Coral International Co., Ltd.).

[0013] In the present invention, from the viewpoint of preventing external stimuli, it is preferable to use one or two types of hydroxyapatite selected from scallop shell-derived hydroxyapatite and fossil coral-derived hydroxyapatite, and it is most preferable to use fossil coral-derived hydroxyapatite.

[0014] The amount of hydroxyapatite blended is 0.0001 to 20% by mass, preferably 0.001 to 10% by mass, of the external skin preparation.

[0015] Polyamine is a general term for aliphatic hydrocarbons having two or more primary amino groups, and is a natural product that is ubiquitously present in living organisms, and more than 20 types of polyamines have been found. Representative polyamines include putrescine, spermidine, and spermine. In the present invention, the polyamine is preferably one or more selected from the group consisting of spermine, putrescine, spermidine, and acetylated forms thereof, and polymers of two or more of these. These may be chemically synthesized or derived from natural products. It is particularly preferable to use polyamines derived from soybean germination extract.

[0016] The amount of polyamine to be blended is not particularly limited, but is usually 0.00005 to 1% by mass, and preferably 0.00005 to 0.1% by mass, based on the total amount of the external skin preparation.

[0017] In the skin external preparation of the present invention, a composite powder in which hydroxyapatite is coated with polyamine can be used. Such a composite powder is prepared by coating 1 part by mass of hydroxyapatite with 0.001 to 1 part by mass, preferably 0.001 to 0.5 part by mass of polyamine.

[0018] As the coating method, various methods known so far can be selected and carried out, such as physicochemical mixing and grinding methods (dry and wet) and chemical deposition methods, but from the viewpoint of stable blending of polyamine, the dry mixing and grinding method is advantageously used.

[0019] The use of the external skin preparation of the present invention is not particularly limited, but it is preferably used as a finishing lotion for finishing makeup or as a sunscreen cosmetic.

[0020] In particular, by using it as a sunscreen cosmetic, it is possible to achieve both ultraviolet protection and protection from external stimuli, which is preferable.

[0021] When used as a sunscreen cosmetic, an ultraviolet scattering agent or an ultraviolet absorbing agent is blended.

[0022] As the ultraviolet scattering agent, it is preferable to use a fine particle metal oxide. In the present invention, fine particles refer to particles having an average particle diameter in the range of about 10 nm to 200 nm. The average particle diameter is a volume-based average particle diameter and can be measured by a laser diffraction / scattering type particle size distribution measuring device. Examples of fine particle metal oxides to be blended in the cosmetic of the present invention include fine particle titanium oxide, fine particle zinc oxide, fine particle zirconium oxide, fine particle cerium oxide, etc. One or two types selected from fine particle titanium oxide and fine particle zinc oxide are preferred because of their excellent ultraviolet scattering effect, and fine particle zinc oxide is particularly preferred because of their excellent UVA blocking effect. The shape of the fine particle metal oxide is not particularly limited, and it may be hydrophilized or hydrophobized.

[0023] The fine titanium oxide particles can be used without any particular limitation as long as they are used in ordinary cosmetics. The shape of the fine titanium oxide particles is not particularly limited. In addition, the particle diameter of the fine titanium oxide particles is preferably, for example, an average particle diameter of the primary particles of 100 nm or less, further 80 nm or less. The lower limit of the average particle diameter of the fine titanium oxide particles is not particularly limited, but is usually about 30 nm. The fine titanium oxide particles can be produced by ordinary methods such as the sulfuric acid method and the chlorine method, and commercially available products can also be used. Examples of commercially available fine titanium oxide particles include SIV series, TTO-55 series, TTO-S series (all manufactured by Ishihara Sangyo Kaisha), MT-100TV, MT-500V, MT-01 (all manufactured by Teika Corporation), etc.

[0024] Titanium oxide microparticles can be used after surface is hydrophilized or hydrophobized as required.Hydrophilic treatment means can be exemplified by surface treatment such as polyhydric alcohol treatment such as glycerin, hyaluronic acid treatment, etc.Furthermore, hydrophobic treatment means can be exemplified by surface treatment such as fluorine compound treatment, silicone treatment, alkyl treatment, alkylsilane treatment, metal soap treatment, water-soluble polymer treatment, amino acid treatment, N-acylamino acid treatment, lecithin treatment, organic titanate treatment, polyol treatment, acrylic resin treatment, methacrylic resin treatment, urethane resin treatment, etc.

[0025] Although the fine particle titanium dioxide and / or its surface-treated fine particle titanium dioxide can be blended directly into cosmetics, it can be used as necessary after coating the surface of other powders such as plate-like powders such as talc, mica, and sericite, silica, and spherical powders. By coating plate-like powders or spherical powders with fine particle titanium dioxide, the aggregation of fine particle titanium dioxide is reduced, and a high ultraviolet protection effect is obtained. In addition, by coating plate-like powders or spherical powders with fine particle titanium dioxide, the rough feeling in use that is peculiar to fine particle titanium dioxide is reduced, and a cosmetic with a good feel in use can be obtained.

[0026] The fine particle titanium dioxide and / or its surface-treated fine particle titanium dioxide can be blended directly in the powder-containing cosmetic composition, but it can also be used after being dispersed in advance in an oil such as silicone oil or hydrocarbon oil, or in an aqueous component.

[0027] The fine zinc oxide particles can be used without any particular limitation as long as they are used in ordinary cosmetics. The shape of the fine zinc oxide particles is not particularly limited. In addition, examples of commercially available fine zinc oxide particles include FINEX-25, FINEX-30, FINEX-50 (all manufactured by Sakai Chemical Industry Co., Ltd.), MZ-300, MZ-500 (all manufactured by Teika Co., Ltd.), etc.

[0028] The zinc oxide microparticles can be used after the surface is hydrophilized or hydrophobized as required.Hydrophilic treatment means can be exemplified by surface treatment such as polyhydric alcohol treatment such as glycerin, hyaluronic acid treatment, etc.Furthermore, hydrophobic treatment means can be exemplified by surface treatment such as fluorine compound treatment, silicone treatment, alkyl treatment, alkylsilane treatment, metal soap treatment, water-soluble polymer treatment, amino acid treatment, N-acylamino acid treatment, lecithin treatment, organic titanate treatment, polyol treatment, acrylic resin treatment, methacrylic resin treatment, urethane resin treatment, etc.

[0029] The fine particle zinc oxide and / or its surface-treated fine particle zinc oxide can be blended directly into cosmetics, but if necessary, it can be used in the form of a coating on the surface of other powders such as talc, mica, sericite, etc., plate-like powders, silica, spherical powders, etc.

[0030] The fine particle zinc oxide and / or its surface-treated fine particle zinc oxide powder can be blended directly into cosmetics, but it can also be used after being dispersed in advance in an oil such as silicone oil or hydrocarbon oil, or in an aqueous component.

[0031] The above-mentioned fine particle metal oxides may be used alone or in combination of two or more kinds.

[0032] The ultraviolet absorbing agent is not particularly limited as long as it can be incorporated into a skin topical agent. For example, cinnamic acid derivatives such as ethyloxyl paramethoxycinnamate, isopropyl methoxycinnamate, isoamyl methoxycinnamate, and ethylhexyl methoxycinnamate; PABA derivatives such as paraaminobenzoic acid (hereinafter abbreviated as "PABA"), ethyl PABA, ethyl-dihydroxypropyl PABA, ethylhexyl-dimethyl PABA, and glyceryl PABA; salicylic acid derivatives such as homosalate, ethylhexyl salicylate, dipropylene glycol salicylate, and TEA salicylate; benzophenone-1, benzyl salicylate, and benzoic acid derivatives such as benzoic acid, ... Benzophenone derivatives such as benzophenone-2, benzophenone-3 or oxybenzone, benzophenone-4, benzophenone-5, benzophenone-6, benzophenone-8, benzophenone-9, and benzophenone-12; benzylidene camphor derivatives such as 3-benzylidene camphor, 4-methylbenzylidene camphor, benzylidene camphorsulfonic acid, benzalkonium camphor methosulfate, terephthalide discamphorsulfonic acid, and polyacrylamidomethyl benzylidene camphor; anisotriazine, Triazine derivatives such as diethylhexylbutamidotriazone, 2,4,6-tris(diisobutyl-4'-aminobenzalmalonate)-s-triazine, 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, and 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine; phenylbenzimidazole derivatives such as phenyldibenzimidazole tetrasulfonic acid disodium salt; Phenylbenzotriazole derivatives such as Trizoletrisiloxane and methylenebis(benzotriazolyltetramethylbutylphenol); anthranil derivatives such as menthyl anthranilate; imidazoline derivatives such as 2-ethylhexyl dimethoxybenzylideneoxoimidazolidinepropionate; benzalmalonate derivatives such as polyorganosiloxanes having benzalmalonate functional groups; 4,4-diarylbutadiene derivatives such as 1,1-dicarboxy(2,2'-dimethylpropyl)-4,4-diphenylbutadiene;Examples of the organic ultraviolet absorbents include octocrylene, diethylaminohydroxybenzoylhexyl benzoate, 4-tert-butyl-4'-methoxydibenzoylmethane, and bisethylhexyloxyphenol methoxyphenyl triazine. These organic ultraviolet absorbents can be used alone or in combination of two or more.

[0033] It is preferable that the skin external preparation of the present invention contains spherical powder, which makes it easier to remove makeup.

[0034] The spherical powder can be used without any particular limitation as long as it is used in ordinary skin external preparations, and may be either inorganic or organic powder.Specifically, examples of inorganic spherical powder include borosilicate (Ca / Na), borosilicate (Ca / Al), silica, titanium oxide, zinc oxide, aluminum oxide, calcium carbonate, zirconium oxide, and cerium oxide, while examples of organic spherical powder include nylon, polymethylmethacrylate, organopolysiloxane elastomer, methylsiloxane network polymer, crosslinked methylpolysiloxane, urethane resin, polystyrene, acrylonitrile-methacrylic acid copolymer, vinylidene chloride-methacrylic acid copolymer, polyethylene, silk, and cellulose.In the present invention, it is preferable to use borosilicate (Ca / Na) from the viewpoint of its makeup removing effect.

[0035] The topical skin preparation of the present invention may further contain, as necessary, oils, surfactants, thickeners, preservatives, fragrances, colorants, moisturizers, antioxidants other than polyamines, anti-inflammatory agents, antibacterial agents, deodorants, adhesives, and the like, within qualitative and quantitative ranges that do not impair the effects of the present invention. EXAMPLES

[0036] The present invention will be described in detail below with reference to examples, but the scope of the present invention is not limited thereto. The blend amounts are expressed in mass % unless otherwise specified.

[0037] [Adsorption effect of air pollutants by hydroxyapatite] An air pollutant dispersion was prepared with the composition shown in Table 1. The dispersion was dispensed into 30 mL glass storage bottles with lids and left to stand, and the settling speed of the pollutants and the transparency of the supernatant after settling were compared. In the following tests, the air pollutant used was Urban Aerosol (ID No.: NIES CRM No. 28, the same applies below), provided by the National Institute for Environmental Studies, a national research and development organization.

[0038] Test Examples 1 to 6 were each dispensed in 40 mL portions into 50 mL glass bottles with lids, and the bottles were simultaneously shaken, after which the settling speed and the transparency of the supernatant after settling were compared and evaluated. [Settling speed] Very fast: ◎ Fast: Yes Moderate:△ Slow: × [Transparency of the supernatant after sedimentation] Very high transparency: High transparency: 〇 Transparency: Medium Low transparency: ×

[0039] [Table 1]

[0040] As shown in Table 1, hydroxyapatite produced a clearer supernatant after sedimentation and had a faster sedimentation speed than borosilicate (Ca / Na) and silica.

[0041] [Inhibitory effect on lipid peroxide (POV) production] A sample was prepared with the composition shown in Table 2. The sample was irradiated with ultraviolet light, and the POV amount before and after irradiation was compared with the standard color and quantified to confirm the lipid peroxide production inhibitory effect. A higher POV value indicates a greater amount of POV produced. The results are also shown in Table 2.

[0042] [Soybean sprout extract coated hydroxyapatite] Hydroxyapatite [Coral Apatite (Coral International)] and soybean sprout extract [Phytopolyamine-S (Toyobo)] were mixed for 2 hours using a blender to obtain soybean sprout extract-coated hydroxyapatite.

[0043] [Table 2]

[0044] [Table 3]

[0045] As shown in Table 2, it was shown that soybean germ extract containing polyamines has the effect of suppressing the production of lipid peroxides caused by artificial sebum. In addition, it was also shown that hydroxyapatite with the surface coated with soybean germ extract has the effect of suppressing the production of lipid peroxides caused by artificial sebum.

[0046] Water-in-oil emulsion foundations were prepared according to the formulations shown in Table 4, and their cleansing properties using cleansing agents were compared.

[0047] [Table 4]

[0048] Note 7: The bead mill dispersion was prepared by adding 9 parts by weight of fine titanium dioxide particles with an average particle size of 0.02 μm coated with 5% by weight of aluminum stearate to 2 parts by weight of dimethicone copolyol and 12 parts by weight of dimethicone, and mixing them using a bead mill. Note 8: Hydrophobized silica-coated zinc oxide microparticles were prepared by coating the surface of 100 parts by mass of zinc oxide microparticles having an average particle size of 0.02 μm with 3 parts by mass of silica, and then treating them with 5 parts by mass of hydrogen dimethicone to make them hydrophobic.

[0049] As shown in Table 4, it was shown that the addition of spherical powder borosilicate (Ca / Na) to cosmetics containing polyamine and hydroxyapatite improved the ease of washing.

[0050] Example 1 Mist spray Soybean sprout extract coated hydroxyapatite 1.0 Ethanol 10.0 PEG-50 hydrogenated castor oil 0.8 Purified water remainder

[0051] Example 2 Lotion Soybean sprout extract 0.01 Marine apatite (made by Japan Barrier Free Co., Ltd.) 2.0 Ethanol 20.0 Purified water remainder

[0052] [Table 5]

[0053] [Table 6]

Claims

1. A topical skin preparation containing hydroxyapatite coated with polyamine-containing soybean sprout extract.

2. 2. The external skin preparation according to claim 1, wherein the polyamine is one or more selected from the group consisting of spermine, putrescine, spermidine, acetylated forms thereof, and polymers of two or more of these.

3. 3. The external skin preparation according to claim 1, which is a sunscreen cosmetic.

4. The external skin preparation according to any one of claims 1 to 3, further comprising spherical powder.

5. The external skin preparation according to any one of claims 1 to 4, wherein the spherical powder is a borosilicate.

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