Two-component medicinal toothpaste set

Abstract

To provide a two-agent type medicated dentifrice set to which active ingredients having pharmacological and cosmetic effects are added, the active ingredients remaining in the oral cavity at high concentrations even after brushing teeth and thereby the pharmacological and cosmetic effects being able to last for a long time, and to provide an oral cleaning method using the two-agent type medicated dentifrice set.SOLUTION: The invention is characterized by containing: a first dentifrice composition that contains green tea extract and dipotassium glycyrrhizinate, a plant extract, a fragrance, a plant-based sweetener, and a dentifrice base and has excellent oral cleaning and sterilizing powers; and a second dentifrice composition that contains dipotassium glycyrrhizinate, a plant extract, a fragrance, a plant-based sweetener, a dentifrice base and an arnica extract, and has excellent antibacterial activity, cosmetic effect, sedative effect, and residual fragrance, after cleaning.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a two-component medicinal dentifrice set, and more specifically, to a two-component medicinal dentifrice set in which active ingredients having pharmacological and cosmetic effects are added to the dentifrice and remain in the oral cavity in high concentrations for a long period of time even after brushing. [Background technology]

[0002] In general, when manufacturing dentifrice, pharmacologically effective ingredients such as antibacterial agents, anti-inflammatory agents, sedatives, and cosmetically effective ingredients such as skin-improving agents, cosmetic agents, fragrances, etc. are blended as active ingredients into base ingredients such as abrasives, foaming agents, moisturizers, surfactants, binders, etc. It is considered desirable to brush your teeth with dentifrice containing such active ingredients before going to bed, sleep, and maintain the active ingredients in a high concentration in the oral cavity until you wake up.

[0003] However, because dental caries and periodontal disease do not involve gram-negative bacteria such as Streptococcus mutans and Porphyromonas gingivalis (see, for example, Patent Document 1), even if one brushes their teeth with a toothpaste containing an antibacterial agent before going to bed to prevent caries, the antibacterial agent is washed out of the mouth when the person rinses their mouth after brushing. Furthermore, the mouth is maintained at a temperature and humidity that favors the proliferation of bacteria while sleeping, causing an increase in the number of bacteria, and therefore the effectiveness of brushing one's teeth with a toothpaste containing an antibacterial agent before going to bed is limited. Therefore, when developing dentifrices with this problem in mind, various techniques for improving the concentration of active ingredients contained in oral preparations such as dentifrices that remain in the oral cavity after oral washing have been studied. For example, Patent Document 1 shows that an oral composition containing mastic and tea tree oil is used in a dentifrice containing licorice extract as an active ingredient, which is effective in preventing and treating periodontal disease.

[0004] However, with the oral composition described in Patent Document 1, the improvement of the oral environment, i.e., the suppression of the number of bacteria, only lasted for a short period of time. As a result, the treatment of periodontal disease took a long period of time, and there were problems such as the need to add further new additives as a remedy.

[0005] Patent Document 2 describes a two-component oral composition having a composition containing a positively charged polymeric compound and a composition containing a negatively charged polymeric compound, and describes an oral composition in which the two compositions are mixed immediately before use to improve the adsorption and retention of the active ingredient in the oral cavity. However, the combination of a composition containing a positively charged polymeric compound and a composition containing a negatively charged polymeric compound requires a complex manufacturing process, and it requires enormous effort and cost to achieve this, making it difficult to manufacture a product that can be expected to have the desired effect.

[0006] Furthermore, even if active ingredients having cosmetic effects such as skin-improving agents, beauty agents, fragrances, etc. are simply added to dentifrice, these active ingredients are washed out of the oral cavity when the mouth is rinsed after brushing the teeth, and the desired effects cannot be obtained for a long period of time. Therefore, there has been a strong demand from consumers, particularly those with periodontal disease and those at risk of developing it, as well as those who are highly conscious of etiquette and who wish to improve their oral environment, keep the oral cavity clean at all times, and suppress bad breath, to provide a dentifrice composition that can maintain a high oral concentration of the active ingredient for a long period of time even after brushing their teeth.

[0007] In some countries, it is customary not to rinse the mouth with water after brushing the teeth with a normal toothpaste containing foaming agents in order to keep the oral cavity healthy, but in Japan, keeping the oral cavity healthy in this way is not common. On the other hand, in Japan, there has long been a custom of drinking green tea, which contains various components, and catechin, a type of polyphenol, is known to have antibacterial properties against oral diseases. Catechin inhibits the growth of bacteria that cause dental caries (tooth decay) and periodontal disease, so it not only has a preventive effect against these diseases, but also helps prevent bad breath by suppressing anaerobic bacteria.

[0008] Furthermore, it was hoped that a toothpaste like this could be developed that would provide oral care by retaining high concentrations of active ingredients with cosmetic effects in the oral cavity, allowing minute amounts of these ingredients to be absorbed into the body, thereby resulting in anti-aging and relaxing effects for the user. [Prior art documents] [Patent documents]

[0009] [Patent Document 1] JP 2004-182649 A [Patent Document 2] JP 2011-46633 A [Patent Document 3] Japanese Patent Application Publication No. 9-87189 [Non-patent literature]

[0010] [Non-Patent Document 1] "Refresh your skin", Technical information, Maruzen Pharmaceutical Co., Ltd., February 3, 2020, p.1-2 Summary of the Invention [Problem to be solved by the invention]

[0011] The object of the present invention is to provide a two-component medicinal toothpaste set which contains active ingredients having pharmacological and cosmetic effects, and which allows the active ingredients to remain in the oral cavity in high concentrations even after brushing, thereby enabling the pharmacological and cosmetic effects to be sustained for a long period of time. [Means for solving the problem]

[0012] As a result of intensive research aimed at solving the above problems, the inventors focused on the pharmacological and cosmetic effects of tea extract (in this invention, tea extract is Ryokucha extract, a component of green tea, and is referred to as "Ryokucha extract") and discovered that the antibacterial effect and collagen regeneration promoting effect of Ryokucha extract could be shared between two toothpaste agents, thereby completing the present invention. In order to solve such problems, the two-component medicinal dentifrice set of the present invention is characterized by comprising: (A1) a first dentifrice composition which contains as active ingredients a yokucha extract and dipotassium glycyrrhizinate, (B1) a plant extract, (C1) a flavoring, (D1) a plant-derived sweetener, and (E1) a dentifrice base and has excellent oral cleaning power; and (A2) a second dentifrice composition which contains as active ingredients a yokucha extract and dipotassium glycyrrhizinate, (B2) a plant extract, (C2) a flavoring, (D2) a plant-derived sweetener, (E2) a dentifrice base, and (F) arnica flower extract and has excellent pharmacological effects, cosmetic effects, and lingering fragrance after cleaning.

[0013] It is also preferred that the second dentifrice composition is a gel. Furthermore, the method is characterized in that a second dentifrice composition is used after the first dentifrice composition is used.

[0014] In addition, the plant extract (B1) of the first dentifrice composition and the plant extract (B2) of the second dentifrice composition may contain at least one selected from aloe juice powder, peony extract, saxifrage extract, aloe extract, hawthorn extract, yarrow extract, sage extract, wild rose extract, rosemary extract, neem leaf extract, and fennel extract. Effect of the Invention

[0015] The two-component medicinal dentifrice set of the present invention contains active ingredients having pharmacological and cosmetic effects, which effectively reduce bacteria when brushing the teeth, and the second dentifrice composition is applied to the teeth and gums after brushing, so that the active ingredients remain in the oral cavity at high concentrations, and the pharmacological effect of antibacterial action and the cosmetic effect of promoting collagen production can be maintained for a long time. Note that the pharmacological effect in this invention mainly means the antibacterial effect, and the cosmetic effect mainly means the effect of promoting collagen production. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0016] Hereinafter, the embodiments of the present invention will be described in detail. This description is for the purpose of explaining the present invention, and is not intended to limit the technical scope of the present invention. The present invention can be implemented in various modifications without departing from the technical scope of the present invention.

[0017] The two-component medicinal dentifrice set of the present invention is characterized by comprising: (A1) a first dentifrice composition which contains as active ingredients a yokucha extract and dipotassium glycyrrhizinate, (B1) a plant extract, (C1) a flavoring, (D1) a plant-derived sweetener, and (E1) a dentifrice base and has excellent oral cleaning power; and (A2) a second dentifrice composition which contains as active ingredients a yokucha extract and dipotassium glycyrrhizinate, (B2) a plant extract, (C2) a flavoring, (D2) a plant-derived sweetener, (E2) a dentifrice base, and (F) an arnica flower extract and has excellent pharmacological effects, cosmetic effects, and lingering fragrance.

[0018] Dipotassium glycyrrhizinate, used in the first dentifrice composition of the two-component medicinal dentifrice set of the present invention, is a plant-derived active ingredient extracted from licorice root. It has excellent anti-inflammatory properties and is used to treat inflammation caused by dental caries and periodontal disease. The content of dipotassium glycyrrhizinate in the first dentifrice composition is 0.01% to 0.1% by mass, and preferably 0.02% to 0.05% by mass, based on the total mass of the first dentifrice composition.

[0019] In addition, the (B1) plant extract of the first dentifrice composition may contain, in addition to the active ingredient, lycium bark extract, at least one selected from aloe juice powder, peony extract, saxifrage extract, aloe extract, hawthorn extract, yarrow extract, sage extract, wild rose extract, rosemary extract, neem leaf extract, and fennel extract.

[0020] The active ingredient of the first dentifrice composition, tea extract, is a plant-derived extract obtained by extracting from the leaves of the Camellia sinensis plant, and has antibacterial and antioxidant effects by inhibiting hydrogen peroxide, nitric oxide production, and lipid peroxide, as well as pigmentation inhibition and deodorizing effects. In addition, it has astringency, umami, and the bitterness of caffeine, so you can feel refreshed through your taste and smell when using it. The content of the Ryokucha extract, which is one of the active ingredients, is 0.001% to 1% by mass, preferably 0.005% to 0.1%, and more preferably 0.01% to 0.08%, based on the total mass of the first dentifrice composition.

[0021] Aloe juice powder is a dried powder of aloe vera leaf juice, and has a therapeutic effect on skin damage and an effect of suppressing melanin production. Furthermore, it also has an anti-inflammatory effect, so bacteria are significantly suppressed. The content of aloe juice powder in the first dentifrice composition is 0.01% to 1% by mass, and preferably 0.05% to 0.5% by mass, based on the total mass of the first dentifrice composition.

[0022] Peony extract is a solution obtained by extracting the roots of the peony plant with water and 1,3-butylene glycol, and has anti-pigmentation effects by inhibiting tyrosinase activity, anti-aging effects by inhibiting neutrophil elastase activity, as well as anti-inflammatory and blood circulation promoting effects. The content of the peony extract in the first dentifrice composition is 0.01% to 0.1% by mass, and preferably 0.02% to 0.08% by mass, based on the total mass of the first dentifrice composition.

[0023] Saxifrage extract is a plant-derived extract obtained from the whole plant of the Saxifragaceae plant, Saxifrage, and has the effect of inhibiting pigmentation by suppressing the release of histamine and melanin production. It also has anti-inflammatory and antibacterial effects, and since it eliminates active enzymes, it is expected to have a synergistic effect with other ingredients that have anti-inflammatory effects. The content of the Saxifrage extract in the first dentifrice composition is 0.01% to 0.1% by mass, and preferably 0.02% to 0.08% by mass, based on the total mass of the first dentifrice composition.

[0024] Aloe extract is made by drying the juice from the leaves of aloe, a perennial plant of the lily family native to Africa. The bitter component of aloe extract, aloin, stimulates peristalsis in the large intestine, facilitating smooth bowel movements. It is used as a laxative in over-the-counter medicines and is also used to treat rough skin, pimples, and loss of appetite (loss of appetite) that accompany constipation. When this component is absorbed through the mouth and taken into the body in small amounts, it stimulates the user's desire to defecate. When bowel movements become smoother, internal inflammation caused by constipation is reduced, and inflammation in the mouth (periodontal disease and stomatitis) can also be prevented and reduced. The content of the aloe extract in the first dentifrice composition is 0.01% to 0.1% by mass, and preferably 0.02% to 0.08% by mass, based on the total mass of the first dentifrice composition.

[0025] Hawthorn extract is an extract from a deciduous tree of the Rosaceae family native to Europe and North Africa, and its leaves and flowers are used in folk and traditional medicine to treat heart failure. The content of the European hawthorn extract in the first dentifrice composition is 0.01% to 0.1% by mass, and preferably 0.02% to 0.08% by mass, based on the total mass of the first dentifrice composition.

[0026] Achillea millefolium extract is an extract extracted from the flowers and leaves of Achillea millefolium, which belongs to the Asteraceae family, and has a tonic effect, promotes appetite, induces sweating, and reduces fever. It is often drunk as herbal tea and is good for promoting human health. By using this ingredient and taking it into the body through the skin in small amounts, it is expected that the user will be energized, stimulate the stomach and intestines, and detoxify from the oral cavity, which will reduce the user's lethargy and listless mood. The content of yarrow in the first dentifrice composition is 0.01% to 0.1% by mass, and preferably 0.02% to 0.08% by mass, based on the total mass of the first dentifrice composition.

[0027] Sage extract is an extract obtained by extracting the leaves of the mint family plant Salvia sage, and contains a lot of flavonoids and tannins as essential oil components, and has various functions such as promoting blood circulation and anti-inflammatory effects, and protects against various skin troubles. By using this ingredient and absorbing it into the body through the skin in small amounts, it is expected that the user's oral mucosa will be improved and wound healing will be promoted. The content of the sage extract in the first dentifrice composition is 0.01% to 0.1% by mass, and preferably 0.02% to 0.08% by mass, based on the total mass of the first dentifrice composition.

[0028] Wild rose extract is an extract made from the fruit of wild rose, a plant of the Rosaceae family. Its ingredients include flavonoids, tannins, vitamins, organic acids, and sugars. Wild rose extract has moisturizing and astringent effects, so it protects the skin from dryness and maintains fine, firm skin. It also has a glamorous side, and since it affects the hormone balance of women in particular, it calms the mind and leads to parasympathetic dominance. By using this ingredient and absorbing it through the skin from the mouth and taking in a small amount into the body, it is expected that the user's oral mucosa will be conditioned and they will feel calm and relaxed. The content of the wild rose extract in the first dentifrice composition is 0.01% to 0.1% by mass, and preferably 0.02% to 0.08% by mass, based on the total mass of the first dentifrice composition.

[0029] Rosemary extract is an extract from the leaves and has antioxidant and anti-aging properties. It also has anti-inflammatory, antibacterial and deodorizing effects, and is refreshing, so it is expected to suppress bacteria in the mouth and provide a refreshing feeling when used. The content of the rosemary extract in the first dentifrice composition is 0.01% to 0.1% by mass, and preferably 0.02% to 0.08% by mass, based on the total mass of the first dentifrice composition.

[0030] Neem is an evergreen tree that grows in tropical regions such as India, South India, Africa, and Central and South America. Neem leaf extract is obtained by extracting neem leaves with 1,3-butylene glycol after heat treatment. It has the effect of eliminating active oxygen, so it is expected to have an anti-aging effect in the oral cavity. In addition, by using this ingredient, it is absorbed through the skin from the oral cavity and taken into the body in small amounts, and as a result, it is expected to have an anti-aging effect in the user's body. The content of neem in the first dentifrice composition is 0.01% to 0.1% by mass, and preferably 0.02% to 0.08% by mass, based on the total mass of the first dentifrice composition.

[0031] Fennel extract is an extract from the seeds of the parsley family, and has the effect of eliminating active oxygen, suppressing bacteria in the oral cavity, and providing a refreshing feeling when used. In addition, since it has the effect of preventing skin aging caused by ultraviolet rays, etc., when used with this ingredient, it is absorbed through the skin from the oral cavity and taken into the body in small amounts, and as a result, it is expected to have a whitening effect on the user. The content of the fennel extract in the first dentifrice composition is 0.01% to 0.1% by mass, and preferably 0.02% to 0.08% by mass, based on the total mass of the first dentifrice composition.

[0032] The flavoring of (C1) of the first dentifrice composition is not particularly limited, but is preferably a menthol-type flavoring having a refreshing feeling. The flavoring may be a synthetic product or a natural organic product. As the menthol-type flavoring, natural organic peppermint is more preferable. The content of the flavoring agent is, in terms of mass %, 0.1% to 2%, and preferably 0.5% to 1.5%, based on the total mass of the first dentifrice composition.

[0033] In addition, the sweetener (D1) may be any one selected from stevia extract and xylitol. Stevia extract has long been used as a sweetener in its country of origin, Paraguay. It contains terpenoid glycosides called stevioside and rebaudioside A as sweetening ingredients. Stevioside is 300 times sweeter than sucrose, so users can feel a sufficient sweetness even with a very small amount, and even if it is ingested, there is little risk of it causing weight gain. The content of the stevia extract in the first dentifrice composition is 0.1% to 1% by mass, and preferably 0.3% to 0.8% by mass, based on the total mass of the first dentifrice composition.

[0034] Xylitol is a sugar alcohol sweetener synthesized from xylose. It does not produce acid by oral bacteria, has the same sweetness as sucrose, is difficult to digest, and has 40% fewer calories than sucrose when eaten. Even if it is ingested, there is little risk that it will lead to weight gain in the user. (D1) As a sweetener, xylitol can be used in place of stevia extract. In that case, the content of xylitol is preferably about 10 times the content of stevia extract. For example, the content of xylitol is 1% to 10% by mass, and preferably 3% to 8% by mass, based on the entire first dentifrice composition.

[0035] The dentifrice base (E1) of the first dentifrice composition may contain an abrasive, a surfactant, a humectant, a binder, etc., as necessary. Of these, the abrasive is a powder component that scrapes off the surface of the teeth without damaging them, and calcium carbonate, hydroxyapatite, calcium hydrogen phosphate, aluminum hydroxide, alumina, silica, etc. can be used.

[0036] As the surfactant, sodium lauryl sulfate, sodium lauroyl sarcosine, sucrose fatty acid ester, polyglyceryl monolaurate, etc. can be used. These surfactants are formulated for various purposes, such as solubilization or emulsification, or as foaming agents, depending on the degree of compatibility with water and oil. For example, polyglyceryl monolaurate has a solubilizing effect as a hydrophilic emulsifier and is generally used for the purpose of dissolving perfumes and oily ingredients transparently and uniformly in a transparent water-soluble base. The content of polyglyceryl monolaurate is 0.5% to 5% by mass, and preferably 1% to 4%, based on the total mass of the first dentifrice composition.

[0037] The humectant is an ingredient that imparts moisture to the dentifrice, and may be glycerin, sorbitol, propylene glycol, 1,2-pentanediol, or the like. The content of the humectant in the first dentifrice composition is 0.5% to 5% by mass, and preferably 1% to 4% by mass, based on the total mass of the first dentifrice composition.

[0038] The binder is a component that binds the powder component and the liquid component to make the dentifrice viscous, and examples of the binder that can be used include xanthan gum, sodium alginate, carboxymethylcellulose, and carrageenan. The content of the binder is 0.1% to 3% by mass, and preferably 0.3% to 1.8%, based on the total mass of the first dentifrice composition.

[0039] The dentifrice base of the first dentifrice composition preferably has a strong cleaning power, and there are no particular limitations on the dentifrice base as long as it is one that can be preferably used in the present invention. For example, concentrated glycerin can be used, and the content of the first dentifrice base is 40% to 70% by mass, and preferably 45% to 60%, based on the total mass of the dentifrice composition.

[0040] The second dentifrice composition of the present invention is characterized by comprising (A2) a second dentifrice composition containing, as active ingredients, ryokucha extract and dipotassium glycyrrhizinate, (B2) a plant extract, (C2) a flavoring, (D2) a plant-derived sweetener, (E2) a dentifrice base, and (F) arnica flower extract, and having excellent pharmacological effects, cosmetic effects, and residual fragrance after rinsing.

[0041] The second dentifrice composition further contains (F) arnica flower extract in addition to the first dentifrice composition, and is characterized by having excellent pharmacological effects, cosmetic effects, and lingering fragrance after rinsing.

[0042] The (A2) active ingredient of the second dentifrice composition, namely, ryokucha extract and dipotassium glycyrrhizinate, (B2) plant extract, (C2) flavoring, and (D2) plant-derived sweetener, may be the same ingredients as the (A1) active ingredient of the first dentifrice composition, namely, ryokucha extract and dipotassium glycyrrhizinate, (B1) plant extract, (C1) flavoring, and (D1) plant-derived sweetener, but the contents thereof may be different.

[0043] The dipotassium glycyrrhizinate used in the second dentifrice composition is a plant-derived active ingredient extracted from licorice root, has excellent anti-inflammatory properties, and is used to treat inflammation caused by dental caries and periodontal disease. The content of dipotassium glycyrrhizinate in the second dentifrice composition is 0.01% to 0.1% by mass, and preferably 0.02% to 0.05%, based on the total mass of the second dentifrice composition.

[0044] In the second dentifrice composition, the active ingredient, tea extract, is a plant-derived extract obtained by extracting from the leaves of the Camellia sinensis plant, and has antibacterial and antioxidant effects by inhibiting hydrogen peroxide, nitric oxide production, and lipid peroxide, as well as pigmentation inhibition and deodorizing effects.In addition, it has astringency, umami, and the bitterness of caffeine, so you can feel refreshed through your taste and smell when using it. Furthermore, in the second dentifrice composition in gel form, the Ryokucha extract is expected to exert the collagen production promoting effect confirmed in Ryokucha extract (Non-Patent Document 1) by being continuously applied to the gum surface in the mouth. This is because, while the formulation of the first dentifrice composition focuses on the antibacterial effect of Ryokucha extract, the formulation of the second dentifrice composition focuses on the collagen production promoting effect of Ryokucha extract. In addition, the ryokucha extract may contain green collagen (plant fiber). The second dentifrice composition is specifically in a gel form to bring out the collagen-producing effect of the ryokucha extract. The second dentifrice composition may further comprise a tea extract, including green tea collagen (a plant fiber). The content of the Ryokucha extract, which is one of the active ingredients, is 0.01% to 1% by mass, preferably 0.05% to 0.5%, and more preferably 0.08% to 0.4%, based on the total mass of the second dentifrice composition.

[0045] The (F) arnica flower extract of the second dentifrice composition is a functional ingredient derived from a plant, and the raw material plant arnica (Japanese name: Seiyo Usagiku) grows naturally in the mountains and pastures of Europe and Central Asia. The arnica flower extract is an extract (plant extract) obtained by extracting the flowers or roots of arnica with water, ethanol, 1,3-butylene glycol, or a mixture of these, and contains ingredients such as flavones, tannins, saponins, tritenoids, and triterpenes.

[0046] In addition, Arnica flower extract has anti-inflammatory, irritation-relieving, and blood circulation-promoting effects, and is expected to reduce inflammation in the oral cavity and promote early wound healing. In addition, since it has moisturizing and astringent effects, it is expected that the ingredient can be absorbed through the oral cavity and taken into the body in small amounts, thereby preventing skin problems such as rough skin and acne. Furthermore, it contributes to maintaining the amount of hyaluronic acid in the body through its activity inhibitory effect on hyaluronidase, a hydrolytic enzyme of hyaluronic acid (e.g., Patent Document 3), and is expected to have a cosmetic effect of reducing wrinkles and nasolabial folds when absorbed through the skin by users who perform oral care. The content of the arnica flower extract in the second dentifrice composition is 0.1% to 3% by mass, preferably 0.5% to 1.5%, and more preferably 0.8% to 1.5%.

[0047] The plant extract (B2) of the second dentifrice composition may include at least one selected from aloe juice powder, peony extract, saxifrage extract, aloe extract, hawthorn extract, yarrow extract, sage extract, wild rose extract, rosemary extract, neem leaf extract, and fennel extract. The content of each of the plant extracts is, in mass %, 0.01% to 0.1%, and preferably 0.02% to 0.08%, based on the total mass of the second dentifrice composition.

[0048] The flavoring of (C2) of the second dentifrice composition is not particularly limited, but is preferably a menthol-type flavoring having a refreshing feeling. The flavoring may be a synthetic product or a natural organic product. As the menthol-type flavoring, natural organic peppermint is more preferable. The content of the flavoring agent is, in terms of mass %, 0.1% to 2%, and preferably 0.5% to 1.5%, based on the total mass of the second dentifrice composition.

[0049] Furthermore, the sweetener (D2) of the second dentifrice composition can be any one selected from stevia extract and xylitol. The content of xylitol in the second dentifrice composition is 0.5% to 10% by mass, and preferably 3% to 8%, based on the total mass of the second dentifrice composition. The content of stevia extract in the second dentifrice composition is 0.1% to 1% by mass, and preferably 0.3% to 0.8%, based on the total mass of the second dentifrice composition.

[0050] The dentifrice base (E2) of the second dentifrice composition may contain an abrasive, a surfactant, a humectant, a binder, and the like, as necessary.

[0051] As the surfactant, sodium lauryl sulfate, sodium lauroyl sarcosine, sucrose fatty acid ester, polyglyceryl monolaurate, etc. can be used. These surfactants are formulated for the purpose of solubilization, emulsification, or foaming, depending on the degree of compatibility with water and oil. For example, polyglyceryl monolaurate is a hydrophilic emulsifier that has a solubilizing effect and is generally used for the purpose of dissolving fragrances and oily ingredients uniformly and transparently in a transparent water-soluble base. The content of polyglyceryl monolaurate in the second dentifrice composition is 0.5% to 5% by mass, and preferably 1% to 4% by mass, based on the entire second dentifrice composition.

[0052] The humectant is an ingredient that imparts moisture to the dentifrice, and may be glycerin, sorbitol, propylene glycol, 1,2-pentanediol, or the like. The content of the humectant in the second dentifrice composition is 0.5% to 5% by mass, and preferably 1% to 4% by mass, based on the entire second dentifrice composition.

[0053] The binder is a component that gives viscosity to the dentifrice, and examples of the binder that can be used include xanthan gum, sodium alginate, carboxymethylcellulose, and carrageenan. In order for the active ingredient of the second dentifrice composition to remain in the oral cavity at a high concentration and for the pharmacological effect of antibacterial activity and the cosmetic effect of promoting collagen production to last for a long time, it is preferable that the dentifrice base (E2) is in a gel form. For this purpose, a binder is blended to give a suitable gel-like viscosity. In addition, the second dentifrice composition (E2) is preferably a gel in which the dentifrice base does not contain a powdered abrasive. The content of the binder is 0.1% to 3% by mass, and preferably 0.3% to 1.8% by mass, based on the entire second dentifrice composition. In the second dentifrice composition of the present invention, the above-mentioned components dissolve in water to form a transparent gel, and the viscosity at 25°C measured at 30 rpm using a Brookfield viscometer equipped with a rotor No. 3 is 5,000 mPa·s to 40,000 mPa·s, preferably 10,000 mPa·s to 35,000 mPa·s, and more preferably 15,000 mPa·s to 30,000 mPa·s. The dentifrice base of the second dentifrice composition preferably has pharmacological and cosmetic effects, and the dentifrice base is not particularly limited as long as it can be preferably used in the present invention. For example, concentrated glycerin can be used, and the content of the second dentifrice base is 40% to 70% by mass, preferably 45% to 60%, based on the total mass of the dentifrice composition.

[0054] The first and second dentifrice compositions each comprising the above-mentioned components can be produced in accordance with a conventional method, and are not particularly limited. The first and second dentifrice compositions thus prepared can be filled into common toothpaste containers such as aluminum tubes, laminate tubes, plastic tubes, plastic bottles, aerosol containers, etc. for use.

[0055] A preferred embodiment of the two-component medicinal dentifrice set of the present invention is to brush the teeth and rinse the mouth with a first dentifrice composition which has strong oral cleansing power and excellent pharmacological effects before going to bed, and then rinse the mouth with a second dentifrice composition in gel form, thereby maintaining a high concentration of active ingredients in the oral cavity for a long period of time.

[0056] [How to use the two-component medicated toothpaste set] The two-component medicinal dentifrice set of the present invention can be used by brushing the teeth with a regular toothbrush, an electric toothbrush, a finger toothbrush or the like with a prescribed amount of the first dentifrice composition, rinsing the mouth with water after brushing the teeth, and then holding the second dentifrice composition in the mouth and rinsing the mouth before spitting it out. The second dentifrice composition can be used by applying it to the entire oral cavity, focusing on the teeth and gums, with a finger, rather than by brushing the teeth as with the first dentifrice composition. The second dentifrice composition can be applied to the teeth and gums using a finger, and then spat out without rinsing the mouth with water, allowing the second dentifrice composition to remain in the mouth at a high concentration. In the two-component medicinal dentifrice set of the present invention, the plant-derived active ingredients effectively reduce bacteria when brushing teeth with the first dentifrice composition, and after brushing, the second dentifrice composition is applied to the teeth and gums, so that the active ingredients remain in the oral cavity in high concentrations, allowing the pharmacological effect of antibacterial action and the cosmetic effect of promoting collagen production to be maintained for a long period of time. Furthermore, by combining a two-component toothpaste that shares the functions of the antibacterial and collagen-producing effects of Ryokucha extract, not only is the active ingredient effective in providing both pharmacological and cosmetic benefits, but the unified refreshing flavor means there is no need to rinse the mouth after use, the effects of the active ingredient last, and the taste of food and drink is not affected even if the food or drink is eaten after use.

[0057] As another method of using the second dentifrice composition, the gel-like second dentifrice composition can be used instead of the first dentifrice composition by brushing the teeth with a finger and then applying it to the entire oral cavity, mainly to the teeth and gums. After applying it to the entire oral cavity, mainly to the teeth and gums, with a finger, the composition can be left in the mouth at a high concentration by spitting it out without rinsing the mouth with water. EXAMPLES

[0058] The present invention will be described in more detail below by way of examples, but the present invention is not limited to these examples.

[0059] [Preparation of the first and second dentifrice compositions] A first dentifrice composition (Production Examples 1 to 3) and a second dentifrice composition (Production Examples 4 to 6) were produced by conventional methods with the compositions (mass%) of each component shown in Tables 1 and 2 so that the base concentrated glycerin accounted for 50 mass% of the total dentifrice composition, and were subjected to the following evaluation tests.

[0060] [Table 1]

[0061] [Table 2]

[0062] [Evaluation test 1] The pharmacological effects of the two-component medicinal dentifrice set of the present invention on bad breath and tongue coating were tested. Evaluation test 1 was conducted using a two-component medicinal dentifrice set consisting of Example 1 (Production Example 1 + Production Example 5), Example 2 (Production Example 2 + Production Example 5), and Example 3 (Production Example 3 + Production Example 5), which is a combination of Production Examples 1 to 3 of a first dentifrice composition and Production Example 5 of a second dentifrice composition. Fifteen subjects with strong bad breath and tongue coating were divided into Example 1 to 3 groups, Comparison Example 1 group described below, and Comparison Example 2 group described below. Five subjects from each group were instructed to carry out the following procedures before going to bed and then to sleep, and were evaluated the following morning.

[0063] Before going to bed, the subject brushed his / her teeth with the first dentifrice composition of the present invention, rinsed his / her mouth once with water, and then used his / her finger to apply the gel-like second dentifrice composition of the present invention to the entire oral cavity, focusing on the teeth and gums, and then spat it out and went to bed. [Comparative Example 1] Before going to bed, the subject brushed his / her teeth with the first dentifrice composition of the present invention, rinsed his / her mouth twice with water, and then went to bed. [Comparative Example 2] Went to bed without brushing his teeth.

[0064] [Evaluation Criteria] (1) Bad breath 1 point: No more bad breath. 2 points: Bad breath has almost disappeared. 3 points: Bad breath was clearly reduced. 4 points: Bad breath was slightly reduced. 5 points: Bad breath has remained the same or worsened slightly (2) tongue coating 1 point: The tongue coating has disappeared. 2 points: The tongue coating has almost disappeared. 3 points: Tongue coating was clearly reduced. 4 points: Tongue coating was slightly reduced. 5 points: Tongue coating has remained unchanged or has worsened slightly.

[0065] [Evaluation results] The following Tables 3 and 4 show the evaluation results for the above-mentioned evaluation criteria of (1) bad breath and (2) tongue coating for the groups of Examples 1 to 3 and the groups of Comparative Examples 1 and 2. The following tables show the number of people who participated in each evaluation.

[0066] [Table 3]

[0067] [Table 4]

[0068] As is clear from Tables 3 and 4, it was confirmed that all 15 people in the groups of Examples 1 to 3 who used the present invention had a dramatic reduction in bad breath and a significant inhibition of tongue coating. In particular, the color of the tongue due to tongue coating did not change much from the state immediately after oral cleaning, and the proliferation of white tongue coating was significantly inhibited. As a result, the bacteria on the enamel of the users' teeth was inhibited, and the surfaces of the teeth remained shiny even after waking up. As shown in Tables 3 and 4, the comparison of the effects of the second dentifrice composition was Example 1<Example 2<Example 3, and the effect of the gel was confirmed. Furthermore, the effect was more pronounced with the increase in the component concentrations of the Ryokucha extract and the Arnica flower extract.

[0069] [Evaluation test 2] Evaluation test 2 was conducted using two-component medicinal dentifrice sets consisting of Example 4 (Production Example 2 + Production Example 4), Example 5 (Production Example 2 + Production Example 5), and Example 6 (Production Example 3 + Production Example 5), which are combinations of Production Example 2 of the first dentifrice composition and Production Examples 4 to 6 of the second dentifrice composition. 25 subjects with swollen and bleeding gums were divided into Example 4 to 6 groups, Comparative Example 3 group, and Comparative Example 4 group, and 5 subjects from each group were instructed to perform the following procedures before going to bed. Before going to bed, the subject brushed their teeth with the first dentifrice composition of the present invention, rinsed their mouth once with water, and then took the gel-like second dentifrice composition of the present invention into their mouth and used their fingers to apply it to the entire oral cavity, focusing on the teeth and gums, then spat it out and went to bed. [Comparative Example 3] Before going to bed, the subject brushed his / her teeth with the first dentifrice composition of the present invention, rinsed his / her mouth twice with water, and then went to bed. [Comparative Example 4] Went to bed without brushing his teeth. The above procedure was repeated for 7 days, after which the state of gum swelling and bleeding was evaluated.

[0070] [Evaluation Criteria] (4) Swollen gums 1 point: The swelling in my gums has gone away. 2 points: The swelling in my gums has almost disappeared. 3 points: Gum swelling was clearly reduced. 4 points: Gum swelling was slightly reduced. 5 points: Gum swelling has remained unchanged or has worsened slightly. (5) Bleeding from the gums 1 point: No more bleeding from the gums. 2 points: Bleeding from gums has almost stopped. 3 points: Gum bleeding was clearly reduced. 4 points: Gum bleeding was slightly reduced. 5 points: Gum bleeding has remained unchanged or has worsened slightly.

[0071] [Evaluation results] The following Tables 5 and 6 show the evaluation results of the above-mentioned evaluation criteria (3) swelling of the gums and (4) bleeding from the gums for the groups of Examples 4 to 6 and the groups of Comparative Examples 3 and 4. The following tables show the number of people for each evaluation.

[0072] [Table 5]

[0073] [Table 6]

[0074] As shown in Tables 5 and 6, it was confirmed that all 15 subjects in the groups of Examples 4 to 6 who used the present invention experienced a reduction in gum swelling and bleeding from the gums. This is because the gums are composed of gingival fibroblasts (gum cells) and extracellular matrices containing various collagens and proteoglycans, and in the case of periodontitis or gingivitis, the balance between the production and decomposition of such matrix proteins is disturbed. It is believed that the collagen production promoting effect confirmed by Ryokucha extract (Non-Patent Document 1) contributes to the balance between the production and decomposition of matrix proteins. Although the preferred embodiments of the present invention have been described above, the present invention is not limited to the above embodiments, and all modifications within the scope of the technical scope of the present invention are included.

[0075] This invention uses plant-derived active ingredients that effectively reduce bacteria while brushing your teeth, and after brushing, Since the second dentifrice composition is applied to the teeth and gums, the active ingredient remains in the oral cavity at a high concentration, allowing the pharmacological effect of antibacterial action and the cosmetic effect of promoting collagen production to be maintained for a long period of time. Furthermore, by combining a two-component toothpaste that shares the functions of the antibacterial and collagen-producing effects of Ryokucha extract, not only is the active ingredient effective in providing both pharmacological and cosmetic benefits, but the unified refreshing flavor means that there is no need to rinse the mouth after use, the effects of the active ingredient last, and the taste of food and drink is not affected even if the food or drink is eaten after use.

Claims

1. (A1) a first dentifrice composition containing, as active ingredients, a ryokucha extract and dipotassium glycyrrhizinate, (B1) a plant extract, (C1) a flavoring, (D1) a plant-derived sweetener, and (E1) a dentifrice base, and having excellent oral cleaning power; and (A2) a second dentifrice composition which contains, as active ingredients, a ryokucha extract and dipotassium glycyrrhizinate, (B2) a plant extract, (C2) a flavoring, (D2) a plant-derived sweetener, (E2) a dentifrice base, and (F) an arnica flower extract, and which has excellent pharmacological effects, cosmetic effects, and residual fragrance after rinsing and application. the second dentifrice composition is in the form of a gel; The ryokucha extract is contained in an amount of 0.001% to 0.08% by mass based on the total amount of the first dentifrice composition, and is contained in an amount of 0.01% to 0.5% by mass based on the total amount of the second dentifrice composition; The dipotassium glycyrrhizinate is contained in the first dentifrice composition in an amount of 0.01% to 0.1% by mass, based on the total mass of the first dentifrice composition, and is contained in the second dentifrice composition in an amount of 0.01% to 0.1% by mass, based on the total mass of the second dentifrice composition; The arnica flower extract is contained in an amount of 0.5% to 1.5% by mass based on the total mass of the second dentifrice composition; The plant extract (B1) of the first dentifrice composition and the plant extract (B2) of the second dentifrice composition each contain at least one selected from aloe vera juice powder, peony extract, saxifrage extract, aloe extract, hawthorn extract, yarrow extract, sage extract, wild rose extract, rosemary extract, neem leaf extract, and fennel extract; Each of the plant extracts is contained in an amount of 0.01% to 0.5% by mass based on the total amount of the first dentifrice composition or the second dentifrice composition; The plant-derived sweetener (D1) of the first dentifrice composition and the plant-derived sweetener (D2) of the second dentifrice composition are either one selected from stevia extract or xylitol; The content of the stevia extract is 0.05% to 1% by mass based on the total mass of the first dentifrice composition; The content of the stevia extract is 0.1% to 1% by mass based on the total mass of the second dentifrice composition; The content of the xylitol is 1% to 10% by mass based on the entire first dentifrice composition or the second dentifrice composition; This two-component medicinal dentifrice set is characterized in that after brushing the teeth with the first dentifrice composition, the second dentifrice composition is used by rinsing the mouth and applying it, so that it remains in a high concentration on the teeth and gums.

2. 2. The two-component medicinal dentifrice set according to claim 1, wherein the viscosity of the second dentifrice composition is within the range of 10,000 mPa·s to 35,000 mPa·s.

3. 3. The two-component medicinal dentifrice set according to claim 2, wherein the second dentifrice composition is used after the first dentifrice composition is used.

4. The yokucha extract of the first dentifrice composition has an antibacterial effect; The two-component medicinal toothpaste set according to claim 1, characterized in that the Ryokucha extract of the second toothpaste composition further has a collagen production effect and has a cosmetic effect when absorbed transdermally from the oral cavity and taken into the body.

5. The two-component medicinal dentifrice set according to claim 1, characterized in that the arnica flower extract of the second dentifrice composition is absorbed transdermally from the oral cavity and taken into the body, thereby providing a cosmetic effect.

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