Hunger reliever

Abstract

To provide a novel appetite reducer.SOLUTION: The appetite reducer contains sea buckthorn juice and / or dried sea buckthorn juice as an active ingredient.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a hunger reliever. [Background technology]

[0002] Hunger is aroused not only by physiological factors, but also by psychological factors such as stress. Overeating due to hunger can have adverse effects on health, such as weight gain and increased risk of lifestyle-related diseases. In order to promote health and prevent disease, it is important to appropriately arouse hunger and establish and maintain a regular dietary lifestyle.

[0003] As for relieving hunger, Patent Document 1 discloses a composition that contains glucomannan and a gum base and relieves hunger by being chewed. Patent Document 2 discloses a hunger relief agent that contains one or more flavors or compounds selected from chamomile oil, lavender oil, patchouli oil, rose blend flavor, vanilla blend flavor, peach blend flavor, raspberry ketone, cyclopentadecanolide, and undecylenic aldehyde. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] JP 2014-075984 A [Patent Document 2] JP 2008-007427 A Summary of the Invention [Problem to be solved by the invention]

[0005] An object of the present invention is to provide a novel agent for alleviating hunger. [Means for solving the problem]

[0006] As a result of intensive research aimed at solving the above problems, the present inventors found that the following invention meets the above object, and thus completed the present invention.

[0007] That is, the present invention relates to the following inventions. <1> A hunger relief agent containing sea buckthorn juice and / or dried sea buckthorn juice as an active ingredient. <2> The composition is for oral administration. <1> A hunger reliever as described in. <3> The intake amount of the sea buckthorn juice and / or dried sea buckthorn juice per adult per day is 1 to 30 g in terms of solid content. <2> A hunger reliever as described in. <4> The aforementioned is used to suppress hunger caused by psychological factors. <1> from <3> 2. The hunger relief agent according to claim 1 . Effect of the Invention

[0008] According to the present invention, a new hunger relief agent is provided. [Brief description of the drawings]

[0009] [Figure 1] FIG. 2 is a diagram for explaining the questionnaire regarding self-evaluation of fatigue used in the subjective evaluation of fatigue (VAS method) in the test of the embodiment. [Diagram 2] 1 is a table summarizing the background of subjects by group in the study of the embodiment. [Diagram 3] 1 is a table summarizing the results of the assessment (VAS) of mental and physical fatigue before and after the intervention of the test of the embodiment. [Figure 4] 1 is a table summarizing the difference in VAS scores for evaluating mental and physical fatigue before and after the intervention in the example test. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] The following is a detailed description of the embodiments of the present invention, but the following description of the constituent elements is one example (representative example) of the embodiment of the present invention, and the present invention is not limited to the following content as long as the gist of the present invention is not changed. Note that in this specification, when the expression "~" is used, it is used as an expression including the numerical values ​​before and after it.

[0011] <Hunger relief agent of the present invention> The present invention relates to a hunger relief agent containing sea buckthorn juice and / or a dried product of sea buckthorn juice as an active ingredient.

[0012] Sea buckthorn (Hippophae rhamnoides L.) is a plant of the Hippophae genus of the Elaeaceae family native to Eurasia. Sea buckthorn fruit contains many physiologically active and antioxidant substances such as malic acid, acetic acid, quinic acid, sitosterol, carotenoids, vitamins, and fatty acids, and is known to have antioxidant effects, an effect of activating natural killer cells, and an effect of increasing the number of helper T cells. However, the hunger-relieving effect of sea buckthorn was not known. The present inventors have newly discovered that sea buckthorn fruit juice can reduce hunger, and the present invention is based on this finding.

[0013] (Sea Buckthorn Juice) Sea buckthorn juice may be the fruit juice itself obtained from sea buckthorn fruits, a concentrated fruit juice obtained by concentrating the fruit juice, a diluted fruit juice obtained by diluting the concentrated fruit juice, etc. Sea buckthorn juice may be a liquid, a semi-liquid such as a puree or a paste, or a mixture thereof.

[0014] Sea buckthorn juice can be obtained by crushing the sea buckthorn fruit by applying pressure using one or more devices such as a mixer, grinder, crusher, crusher, and squeezer, and then subjecting the fruit to centrifugation, filtration, straining, concentration, dilution, and the like as appropriate. In this case, the sea buckthorn fruit may be used in a state including the skin and seeds, or may be used after removing the skin, or only the flesh portion from which the skin and seeds have been removed may be used. A pureed sea buckthorn juice obtained by straining the sea buckthorn fruit is one of the preferred forms. Straining can be performed by passing the fruit through a mesh (for example, 40 to 60 mesh). Straining can remove at least a part of the skin, seeds, and fibrous flesh of the fruit.

[0015] Sea buckthorn juice is preferably obtained from a fruit including the skin, pulp and seeds. For example, a liquid, semi-liquid or mixture thereof obtained by crushing sea buckthorn fruit including the skin, pulp and seeds under pressure and then subjecting the fruit to centrifugation, filtration, straining, concentration, dilution or the like can be used.

[0016] (Dried sea buckthorn juice) The dried sea buckthorn juice is obtained by drying sea buckthorn juice. Drying can be carried out by known drying methods such as sun drying, heat drying, vacuum drying, lyophilization (freeze drying), spray drying, etc. The dried product is preferably made into a dry powder by pulverizing or powdering during drying using spray drying, etc.

[0017] The hunger relief agent of the present invention is preferably an oral composition. Sea buckthorn juice and / or dried sea buckthorn juice can be used as a product as is or mixed with other materials to make a product. Sea buckthorn juice and / or dried sea buckthorn juice are derived from natural products, so they are safe, have good taste, and can be easily processed into a form that is easy to take on a daily basis. There are no particular limitations on the use of the oral composition, and it can be used as a food composition, a pharmaceutical composition for oral administration, etc.

[0018] (Food composition) The hunger relief agent of the present invention is preferably in the form of a food composition. By making it into a food composition that is easy to take orally on a daily basis, it is also easy to take it for a long time. This food composition includes not only general foods, but also foods and beverages taken for the purpose of maintaining and improving health, such as special purpose foods, foods for specified health uses, foods with functional claims, foods with nutrient functions, nutritional supplements, health supplements, and supplements, and can be provided with the relief, reduction, and suppression of hunger displayed on the package based on the display method approved for each type of food. Among these, foods with health functions, such as foods for specified health uses, foods with functional claims, and foods with nutrient functions, are preferred forms.

[0019] When commercializing as a food composition, it may be a product consisting of sea buckthorn juice and / or a dried product of sea buckthorn juice, or may be blended into food or beverage. When commercializing as a food composition, in addition to the sea buckthorn juice and / or a dried product of sea buckthorn juice, various additives used in food and beverage may be added. Specifically, coloring agents, preservatives, thickening stabilizers, antioxidants, bleaching agents, antibacterial and antifungal agents, acidulants, seasonings, emulsifiers, strengthening agents, manufacturing agents, flavorings, sweeteners, etc. may be added.

[0020] The shape of the food composition is not particularly limited, and may be any of solid, liquid, semi-solid, gel, sol, etc. Foods and beverages that are the subject of the food composition are not particularly limited. For example, foods include confectioneries such as jelly, candy, and chewing gum, and foods such as sausage, ham, and seafood products. In addition, beverages include sea buckthorn juice drinks, other fruit juice drinks, teas, soft drinks, alcoholic beverages, and nutritional drinks. From the viewpoint of being able to use sea buckthorn juice as it is and being able to increase its content, it is preferable to have it in the form of a beverage (such as a liquid beverage or puree).

[0021] It may also be made into an animal food composition, and sea buckthorn juice and / or a dried product of sea buckthorn juice may be added to an animal food composition such as pet food.

[0022] Pharmaceutical Compositions The hunger relief agent of the present invention can be prepared as a pharmaceutical composition for oral administration by blending sea buckthorn juice and / or a dried product of sea buckthorn juice with a pharma- ceutical acceptable carrier. In the present invention, the pharmaceutical composition includes not only pharmaceuticals but also quasi-drugs. The dosage form of the pharmaceutical composition is not particularly limited, and may be a solid preparation or a liquid preparation. Specific examples include powders, granules, tablets, capsules, lozenges, suspensions, emulsions, syrups, and elixirs. Pharmaceutically acceptable carriers include, for example, binders, stabilizers, excipients, diluents, pH buffers, thickeners, colorants, dispersants, emulsifiers, suspending agents, preservatives, disintegrants, solubilizers, and dissolution aids.

[0023] The hunger relief agent of the present invention (including embodiments such as food compositions and pharmaceutical compositions) may contain components other than sea buckthorn juice and / or dried sea buckthorn juice, as described above. The amount of sea buckthorn juice and / or dried sea buckthorn juice in the hunger relief agent of the present invention (including embodiments such as food compositions and pharmaceutical compositions) varies depending on the embodiment and the method of ingestion, and is appropriately adjusted. For example, when sea buckthorn juice is contained, the content of sea buckthorn juice in the hunger relief agent of the present invention (mass of sea buckthorn juice / mass of the hunger relief agent of the present invention x 100 (%)) can be 30% by mass or more, 50% by mass or more, 60% by mass or more, 70% by mass or more, 80% by mass or more, 90% by mass or more, etc. In addition, the content of sea buckthorn juice in the hunger relief agent of the present invention may be appropriately set to an upper limit such as 100% by mass or less, 99.99% by mass or less, 99.98% by mass, etc.

[0024] The content of sea buckthorn juice and / or dried sea buckthorn juice in the hunger relief agent of the present invention is preferably 1% by mass or more, 2% by mass or more, 3% by mass or more, 4% by mass or more, 5% by mass or more, etc., calculated as solid content. There is no particular limitation on the upper limit, but the upper limit may be appropriately set, such as 20% by mass or less or 15% by mass, calculated as solid content. The solid content of sea buckthorn juice is the mass of sea buckthorn juice excluding water. For example, unconcentrated sea buckthorn juice or puree contains about 80 to 90% by mass of water, so the solid content is about 10 to 20% by mass, and the solid content in 100 mL is about 10 to 25 g. The mass of dried sea buckthorn juice is used as the solid content.

[0025] The intake amount of the hunger relief agent of the present invention (including the embodiment of a food composition or a pharmaceutical composition) is appropriately selected depending on the embodiment of the agent, the intake method, etc., but the intake amount of sea buckthorn juice and / or dried sea buckthorn juice per adult is preferably 1 g or more in solid content, more preferably 2 g or more, and even more preferably 3 g or more, per day. The upper limit is not particularly limited, but from the viewpoint of ease of intake, etc., it is preferable to take 30 g or less in solid content, more preferably 25 g or less, 20 g or less, 15 g or less, 10 g or less, 9 g or less, 8 g or less, 7 g or less, and even more preferably 6 g or less. In addition, the intake can be performed once or in multiple divided doses per day, and may be continuously taken for several days to several weeks or months. The intake amount of seabuckthorn juice and / or dried seabuckthorn juice is calculated from the solid content of the seabuckthorn juice if only seabuckthorn juice is included, calculated from the mass of the dried seabuckthorn juice if only dried seabuckthorn juice is included, and calculated from the sum of the solid content of the seabuckthorn juice and the mass of the dried seabuckthorn juice if seabuckthorn juice and its dried product are included.

[0026] The hunger relief agent of the present invention can be used for animals including humans, and non-human animals such as dogs and cats.

[0027] The hunger relief agent of the present invention can be used to relieve hunger, and in particular, can be used to relieve hunger caused by psychological factors. Hunger caused by psychological factors such as psychological fatigue can arouse appetite outside of normal meal times such as breakfast, lunch, and dinner, which can lead to overeating. Arousal of hunger limited to three meal times a day due to physiological needs is important for building and maintaining regular lifestyle habits, and leads to health promotion and disease prevention. Preventing overeating due to psychological fatigue is important for maintaining health. By taking the hunger relief agent of the present invention, excessive snacking can be suppressed, and overeating caused by psychological factors can be prevented. Hunger may be evaluated by VAS, and the hunger relief agent of the present invention can reduce the score of hunger evaluated by VAS. EXAMPLES

[0028] The present invention will be described in more detail below with reference to examples. However, the present invention is not limited to the following examples unless the gist of the present invention is changed.

[0029] [Example] I. Preparation of Sea Buckthorn Juice The fruits of H. rhamnoides (with flesh, skin and seeds, from Manhan Mountain, Inner Mongolia) with the leaves and branches attached were frozen at -18℃, and the leaves and branches were removed while still frozen, and washed with drinking water. Damaged fruits were removed. The fruits with the skin attached were then put into a blender and made into a puree, which was then strained through a mesh (60 mesh) to remove the skin residue and seeds, and then flash sterilized at high temperature to obtain sea buckthorn juice (puree).

[0030] II. Preparation of Sea Buckthorn Juice Drink Stevia was added to the sea buckthorn juice obtained in I, and the mixture was mixed while removing foreign matter through a mesh (40 mesh), and then heat sterilized to obtain a sea buckthorn juice drink containing 99.95% by mass of sea buckthorn juice.

[0031] III. Testing A four-week, placebo-controlled, double-blind, randomized, parallel-group comparative study was conducted in healthy middle-aged women to examine the effectiveness of consuming sea buckthorn juice drink in improving physical and mental fatigue.

[0032] (i) Study design 1. Subjects and Methods The randomized, placebo-controlled, double-blind, parallel-group comparative study was conducted over a four-week period from late August to late September 2021. The study plan was approved by the Kindai University Ethics Committee (approval number 2021002). The study was conducted in compliance with the Declaration of Helsinki (Fortaleza Amendment, 2013) and the Ethical Guidelines for Medical Research Involving Human Subjects (Notification No. 1 of the Ministry of Education, Culture, Sports, Science and Technology, Ministry of Health, Labor and Welfare, and Ministry of Economy, Trade and Industry, 2021). The study personnel provided a thorough explanation of the purpose and content of the study to the subjects in advance, and after confirming that the subjects fully understood and agreed with the content, they obtained written, voluntary consent to participate in the study.

[0033] 2. Target Audience The subjects were selected as follows: 1) those who understood the contents of the study and provided written consent, 2) those who could take the test supplement every day during the study period, 3) those who could undergo all necessary measurements, and 4) healthy adult women who were healthy and met the inclusion criteria listed below and did not violate the exclusion criteria.

[0034] Selection Criteria 1) Women aged 30 to 55 2) People who are generally healthy but feel fatigued ·Exclusion criteria 1) Subjects who are continuously taking health foods, quasi-drugs, or medicines that claim or emphasize similar or related effects or efficacy to those examined in this study 2) Those who have changed or started using a new health food within the past two weeks 3) Those who work night shifts or day / night shifts 4) Those who are receiving treatment (hormone replacement therapy, drug therapy, exercise therapy, diet therapy) at a medical institution for the treatment or prevention of a disease, or who are judged to be in need of treatment 5) Subjects with a history of serious diseases of glucose metabolism, lipid metabolism, liver function, kidney function, heart, circulatory system, respiratory system, endocrine system, immune system, nervous system, or mental illness. 6) Those with a history of alcohol or drug dependence 7) People who are at risk of developing food allergies 8) Pregnant, breastfeeding, or those hoping to become pregnant during the study period 9) Subjects who have participated in other human trials (human trials using food, pharmaceuticals, quasi-drugs, medical devices, etc.) within the past 2 weeks, or who are scheduled to participate in other human trials during the planned period. 10) Any other person who is deemed inappropriate for the study by the study director or study participants

[0035] 3. Allocation During the contracted study period, after entering and checking the data from the screening test, the person in charge of allocation, who was not directly involved in the study, used this data to randomly allocate the subjects into two groups so that age and BMI did not differ significantly between the groups. The allocation list was provided only to the contracted study organization, and the test supplements were mailed to the subjects according to this allocation list. The allocation list was kept secure until the statistical analysis method was finalized.

[0036] 4. Test Food The intervention group used the sea buckthorn juice drink obtained in II as the test food. The placebo group was made so that the subjects could not distinguish between the two based on appearance, taste, or smell. The placebo was a drink made by mixing 0.5 mL of Casamas Yellow dye, 0.02 mL of Kiriyas Red dye, 0.38 g of 85% phosphoric acid, 5 g of granulated sugar, and 1.2 g of Crepe in 100 mL of water. Subjects consumed 30 mL of the test food or placebo daily for four weeks.

[0037] 5. Evaluation items and measurements 1) Evaluation items and measurements All items were measured twice, before and after the intervention, at the Kyushu University Hospital campus. Evaluation of mental and physical fatigue (visual analogue scale method) was performed using a self-assessment questionnaire on mental and physical fatigue. The VAS method was used to assess 12 symptoms that appear during mental and physical fatigue (see Figure 1).

[0038] 2) Visual Analogue Scale (VAS) for assessment of mental and physical fatigue The subjective assessment of fatigue (VAS method) is a questionnaire regarding self-evaluation of fatigue. When using the VAS method, the lower the number, the better the condition. The VAS method involves drawing a 100mm line on a blank sheet of paper, with the left side of the line representing "the best feeling of not feeling tired at all" and the right side representing "the worst feeling of being so tired that you cannot do anything," and the subject is asked to draw a line to indicate their current state of fatigue (see Figure 1). After having the subject draw the line, the person measuring uses a ruler to record how many millimeters from the left the line is drawn.

[0039] 6. Assessment of adverse events During the pre-measurement, the subjects' medical history and subjective symptoms were confirmed using a questionnaire, and they were also interviewed by a doctor. A system was established to quickly obtain information if there were any changes in their physical condition after the intervention.

[0040] 7.Statistical methods For each item, the average value and standard error for the intervention group and placebo group were calculated, and a paired t-test was used to compare each item before and after intake. In addition, an independent sample t-test was performed to compare the difference before and after the intervention to see if there was a difference between the intervention group and the placebo group in terms of the change in values. The significance level was set at 5%, and a difference of less than 5% was considered significant. SPSS statistic 26 (IBM) was used for statistical analysis.

[0041] (ii) Results 1. Background of the subjects Thirty-nine subjects were randomly assigned to the intervention group, with 20 in the intervention group and 19 in the placebo group. However, nine subjects were excluded: five in the intervention group who did not meet the eligibility criteria, three in the placebo group, and one in the intervention group whose drinking rate was less than 80% after the trial ended. The final number of subjects was 14 in the intervention group and 16 in the placebo group. Figure 2 shows the background of the 30 subjects by group (average age and BMI). As shown in Figure 2, there was no significant difference in age or BMI between the two groups.

[0042] 2. Efficacy Analysis Figures 3 and 4 show the results of the VAS evaluation of mental and physical fatigue. As shown in Figure 3, in the change before and after the intervention in "hunger," only the intervention group showed a significant decrease (P = 0.036), while the placebo group showed an increase in the average value, although it was not significant. As shown in Figure 4, in the difference before and after the intervention, a significant difference was seen between the intervention group and the placebo group only in "hunger" (P = 0.045).

[0043] 3. Safety Evaluation No adverse events were observed during the study period.

[0044] (iii) Discussion The results of this study showed that ingesting the test food has the effect of suppressing hunger. Hunger is aroused not only by physiological factors, but also by psychological factors such as stress. It is believed that these results were due to the fact that ingesting the test food reduced mental and physical fatigue and enabled people to spend each day in an active mood, thereby suppressing hunger caused by psychological fatigue. The various physical symptoms caused by this psychological fatigue may lead to reduced physical activity and increased time spent sitting, which may increase the opportunities for snacking, but this is merely speculation.

[0045] The results of this study demonstrated that the sea buckthorn juice drink suppressed hunger, and no adverse events were reported, confirming the safety of ingesting the test food.

[0046] (iv) Conclusion The effect of ingestion of sea buckthorn juice drink in reducing hunger was confirmed. The safety of the test food was also confirmed. [Industrial Applicability]

[0047] The hunger alleviating agent of the present invention can be used in foods, medicines, etc. and is industrially useful.

Claims

1. An agent for reducing hunger caused by psychological factors, characterized by containing sea buckthorn juice and / or dried sea buckthorn juice as an active ingredient (excluding cases containing chia seeds).

2. The agent according to claim 1, which is an oral composition.

3. The agent according to claim 2, wherein the intake amount of the sea buckthorn juice and / or the dried product of the sea buckthorn juice per adult per day is 1 to 30 g in terms of solid content.

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