Pesticide composition and method for controlling pests

Abstract

Provided are a harmful organism control agent composition and a harmful organism control method that are excellent in ability of killing adults, larvae, or eggs, particularly eggs, of harmful organisms such as insects and mites that are harmful to plants.　The present invention pertains to: a harmful organism control agent composition containing a calcium-activated potassium channel modulator such as acynonapyr, and an active ingredient of a silicone-based spreader or a spiracle-blocking agent such as a sorbitan fatty acid ester, a glycerol citric acid fatty acid ester, and a polyoxyethylene methyl polysiloxane; and a harmful organism control method including applying simultaneously or in any order, to a target, a calcium-activated potassium channel modulator, and an active ingredient of a silicone-based spreader or a spiracle-blocking agent, or applying, to a target, a harmful organism control agent composition containing a calcium-activated potassium channel modulator, and an active ingredient of a silicone-based spreader or a spiracle-blocking agent.

Description

[Technical Field]

[0001] The present invention relates to a pesticide composition and a method for controlling pests. More particularly, the present invention relates to a pesticide composition and a method for controlling pests that are excellent in killing adults, larvae, or eggs of pests such as insects or mites that are harmful to plants, particularly in killing eggs. This application claims priority to Japanese Patent Application No. 2023-193041, filed November 13, 2023, the contents of which are incorporated herein by reference. [Background technology]

[0002] A pest control agent has been proposed that contains, as an active ingredient, a chemical substance capable of altering the activity of an insect-derived voltage-gated potassium channel or an agriculturally acceptable salt thereof (Patent Document 1).

[0003] Also known is 3-endo-[2-propoxy-4-(trifluoromethyl)phenoxy]-9-[5-(trifluoromethyl)-2-pyridyloxy]-9-azacyclo[3.3.1]nonane (formula (A): acinonapyr) or its salts, which are thought to exhibit acaricidal activity by acting on inhibitory glutamate receptors and disrupting neurotransmission in spider mites, causing behavioral abnormalities (Patent Document 2, Patent Document 3). Acinonapyr is a compound belonging to Group 33: calcium-activated potassium channel (KCa2) modulators according to the Insecticide Mechanism of Action Classification (IRAC classification). [ka]

[0004] Another known insecticide is N-(cyanomethyl)-4(trifluoromethyl)nicotinamide (flonicamid), which belongs to Group 29: chordotonal organ modulators in the Insecticide Mechanism of Action Classification (IRAC Classification). Subsequent research into the mechanism of action of flonicamid has revealed that it acts on calcium-activated delayed rectifier voltage-gated potassium channels (Slowpoke) and voltage-gated delayed rectifier potassium channels (Shab, Shaw) located at the junction between muscles and motor neurons. This has been considered to inhibit sap-sucking in aphids and other insects, and to inhibit mating by preventing males from emitting normal mating sounds due to abnormal physical behavior, which prevents the smooth mating behavior associated with the generation of female response signals (Non-Patent Document 1).

[0005] On the other hand, Patent Document 4 discloses an active compound combination comprising a fatty acid, a fatty acid salt or a fatty acid ester and an insecticide active ingredient. Patent Document 5 discloses an insecticide characterized by containing a fatty acid glyceride having 8 to 22 carbon atoms and a macrolide insecticide. Examples of the macrolide insecticides disclosed include spinosad, emamectin benzoate, milbemectin, and nemadectin. Macrolide insecticides are compounds that belong to Group 6: glutamate-gated chloride channel (GluCl) allosteric modulators according to the Insecticide Mechanism of Action Classification (IRAC classification). [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Japanese Patent Application Laid-Open No. 2010-75057 [Patent Document 2] WO 2019 / 176676 A1 [Patent Document 3] WO 2017 / 195734 A1 [Patent Document 4] WO 2021 / 099271 A1 [Patent Document 5] WO 2005 / 036965 A1 [Non-patent literature]

[0007] [Non-Patent Document 1] Development of the insecticide flonicamid and research into its mechanism of action - Lecture given at the 2nd regular meeting of the 189th Committee on New Developments in Chemical Biology in Japan - Yoshida Kiyoshi, Ishihara Sangyo Kaisha, Ltd. (http: / / www.npd.riken.jp / jsps / slides.html) Summary of the Invention [Problem to be solved by the invention]

[0008] An object of the present invention is to provide a pest control composition and a method for controlling pests, which have excellent biocidal properties against adults, larvae, or eggs of pests such as insects or mites that are harmful to plants, and in particular, have excellent biocidal properties against eggs. [Means for solving the problem]

[0009] The present invention includes the following aspects.

[0010] [1] Calcium-activated potassium channel modulators The active ingredient of a stigma-blocking agent or a silicone-based spreading agent A pesticide composition comprising:

[0011] [2] The calcium-activated potassium channel modulator is acinonapir; The pest control composition according to [1], wherein the active ingredient of the stigma-blocking agent or silicone-based spreading agent is at least one selected from the group consisting of fatty acid glycerides, blended oils, sorbitan fatty acid esters, glycerin citrate fatty acid esters, polyglycerin fatty acid esters, and polyoxyethylene methylpolysiloxanes.

[0012] [3] The pest control composition according to [1] or [2], wherein the active ingredient of the stigma-blocking agent or silicone-based spreading agent is at least one selected from the group consisting of sorbitan fatty acid esters, glycerin citrate fatty acid esters, and polyoxyethylene methylpolysiloxanes.

[0013] [4] The amount of the active ingredient of the stigma-blocking agent or silicone-based spreading agent relative to 1 part by weight of the calcium-activated potassium channel modulator is 1 to 2000 parts by weight, and The pest control composition according to any one of [1] to [3], which, when diluted, can achieve a concentration of the calcium-activated potassium channel modulator of 1 ppm or more and 1000 ppm or less, and a concentration of the active ingredient of the stigma-blocking agent or the silicone-based spreading agent of 100 ppm or more and 5000 ppm or less.

[0014] [5] The pest control composition according to any one of [1] to [4], wherein the pest is an insect or a mite harmful to plants.

[0015] [6] Applying the calcium-activated potassium channel modulator and the active ingredients of the stigma-blocking agent or silicone-based spreading agent to the target object simultaneously or in any order; or A method for controlling pests comprising applying to an object a pest control composition containing a calcium-activated potassium channel modulator and an active ingredient of a stigma-blocking agent or a silicone-based spreading agent. Pest control methods.

[0016] [7] The calcium-activated potassium channel modulator is acinonapir; The method for controlling pests according to [6], wherein the active ingredient of the stigma-blocking agent or silicone-based spreading agent is at least one selected from the group consisting of fatty acid glycerides, blended oils, sorbitan fatty acid esters, glycerin citrate fatty acid esters, polyglycerin fatty acid esters, and polyoxyethylene methylpolysiloxanes.

[0017] [8] The method for controlling pests according to [6] or [7], wherein the active ingredient of the stigma-blocking agent or silicone-based spreading agent is at least one selected from the group consisting of sorbitan fatty acid esters, glycerin citrate fatty acid esters, and polyoxyethylene methylpolysiloxanes.

[0018] [9] The amount of the active ingredient of the stigma-blocking agent or silicone-based spreading agent relative to 1 part by weight of the calcium-activated potassium channel modulator is 1 to 2000 parts by weight; The concentration of the calcium-activated potassium channel modulator at the time of application is 1 ppm or more and 1000 ppm or less, and The method for controlling pests according to any one of [6] to [8], wherein the concentration of the active ingredient of the stigma-blocking agent or silicone-based spreading agent at the time of application is 100 ppm or more and 5000 ppm or less.

[0019]

[10] The method for controlling pests according to any one of [6] to [9], wherein the pests are insects or mites that are harmful to plants. [Effects of the Invention]

[0020] The pesticide composition and method for controlling pests of the present invention have excellent killing properties against adults, larvae, or eggs of pests such as insects or mites that are harmful to plants, particularly against eggs. In the pesticide composition and method for controlling pests of the present invention, the active ingredient of the stigma-blocking agent or silicone-based spreading agent kills pests by physical control, making it difficult for pests to acquire drug resistance. DETAILED DESCRIPTION OF THE INVENTION

[0021] The pesticide composition of the present invention contains a calcium-activated potassium channel modulator and an active ingredient of a stigma-blocking agent or a silicone-based spreading agent.

[0022] Potassium channels are proteins that allow selective membrane permeation of potassium ions. Calcium-activated potassium channels (KCa channels) are a type of potassium channel that allow selective membrane permeation of potassium ions. 2+ It is said that activity increases with increasing concentration. Potassium permeation causes fluctuations in membrane potential. These fluctuations are said to induce abnormal behavior in harmful organisms. Calcium-activated potassium channel modulators have the function of regulating the activity of calcium-activated potassium channels. Examples of calcium-activated potassium channel modulators include acinonapir. Examples of commercially available products containing calcium-activated potassium channel modulators as active ingredients include DANYOTE (registered trademark).

[0023] Stomata blockers suffocate and kill pests by adhering to them. Stomata blockers can be broadly divided into three types: sugar-based, oil-based, and surfactant-based.

[0024] The active ingredients of sugar-based stigma-blocking agents are sugars such as hydroxyalkyl starch and starch saccharification products. Examples of starch saccharification products include reduced starch saccharification products, starch syrup, oligosaccharides, D-sorbitol, and the like. Commercially available sugar-based stigma-blocking agents include Nenkinkun (registered trademark, active ingredient: hydroxypropyl starch, manufactured by Sumitomo Chemical Co., Ltd.) and Ecopita Liquid (registered trademark, active ingredient: reduced starch saccharified product, manufactured by Kyoyu Agri Co., Ltd.) The active ingredients of sugar-based stigma-blocking agents tend to be more effective when diluted 100 to 200 times.

[0025] The active ingredients of oil-based spiracles sealants are oils and fats such as fatty acid glycerides, compound oils, and machine oils.

[0026] Fatty acid glycerides are esters of fatty acids and glycerides, and the fatty acids are not particularly limited. The fatty acids may be linear, branched, or cyclic, and may be saturated or unsaturated. The number of carbon atoms in the fatty acids is usually 4 to 22. Examples of fatty acids include caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, and linoleic acid. The esters may be mono-, di-, or triesters, and the fatty acids may be the same or different.

[0027] The blended oil is a mixture of two or more oils selected from olive oil, sesame oil, rice bran oil, safflower oil, soybean oil, corn oil, rapeseed oil, palm oil, palm kernel oil, sunflower oil, cottonseed oil, coconut oil, peanut oil, camellia oil, almond seed oil, avocado oil, tea oil, etc. Machine oil is a paraffinic hydrocarbon, i.e., a mineral oil.

[0028] Examples of commercially available oil-based stigma sealants include Sun Crystal Emulsion (registered trademark, manufactured by Sankei Chemical Co., Ltd.) and Saf Oil Emulsion (registered trademark, manufactured by OAT Agrio Co., Ltd.) The active ingredients of oil-based stigma sealants tend to be more effective when diluted 100 to 600 times.

[0029] The active ingredient of the surfactant-based stigma-blocking agent is a surfactant such as glycerin citrate fatty acid ester, sorbitan fatty acid ester, polyoxyethylenemethylpolysiloxane, polyglycerin fatty acid ester, propylene glycol mono-fatty acid ester, or fatty acid sodium salt.

[0030] Glycerin citrate fatty acid esters are ester compounds of glycerin with one or two citric acids and one or two mono- or di-fatty acids, and the fatty acids include those exemplified above for the fatty acid glycerides. When multiple fatty acids are present, the fatty acids may be the same or different.

[0031] Sorbitan fatty acid esters are mono-, di-, tri-, or tetraesters of sorbitan with fatty acids. Examples of the fatty acids include those exemplified above for the fatty acid glycerides.

[0032] Polyoxyethylenemethylpolysiloxane is a copolymer represented by the following formula: [ka]

[0033] Polyglycerol fatty acid esters are ester compounds of glycerol polymers and fatty acids, and the number of ester bonds is 1 to n+2 (n is the polymerization number of glycerol). Examples of the polyglycerin in the polyglycerin fatty acid ester include diglycerin, triglycerin, tetraglycerin, hexaglycerin, and decaglycerin. Examples of the fatty acid in the polyglycerin fatty acid ester include the same as those exemplified for the fatty acid glycerides above. The number of ester bonds may be di-, tri-, penta-, hexa-, deca-, and the like.

[0034] Examples of the fatty acids of the propylene glycol mono-fatty acid esters and fatty acid sodium salts include the same as those exemplified above for the fatty acid glycerides.

[0035] Commercially available surfactant-based stigma sealants include Mushirap Emulsion (registered trademark: manufactured by Maruwa Biochemical Co., Ltd.), Akaritouch Emulsion (registered trademark: manufactured by OAT Agrio Co., Ltd.), Olate Liquid (registered trademark: manufactured by OAT Agrio Co., Ltd.), Fumon (registered trademark: manufactured by Nippon Kayaku Co., Ltd.), Dualside Wettable Powder (registered trademark: manufactured by Kaken Pharmaceutical Co., Ltd.), and Pitaichi Emulsion (registered trademark: manufactured by Kyoyu Agri Co., Ltd.). The active ingredients of surfactant-based stigma sealants tend to be more effective when diluted 500 to 1000 times.

[0036] The active ingredient of a silicone-based spreading agent is a silicone-based surfactant such as polyoxyethylenemethylpolysiloxane. Commercially available silicone-based spreading agents include Makupika (registered trademark, manufactured by Ishihara Biosciences Co., Ltd.). The active ingredient of a silicone-based spreading agent tends to be more effective when diluted 500 to 1000 times.

[0037] Of these, the active ingredient of the stigma-blocking agent or silicone-based spreading agent is preferably at least one selected from the group consisting of polyglycerin fatty acid esters, fatty acid glycerides, blended oils, sorbitan fatty acid esters, glycerin citrate fatty acid esters, and polyoxyethylene methylpolysiloxanes, and more preferably at least one selected from the group consisting of sorbitan fatty acid esters, glycerin citrate fatty acid esters, and polyoxyethylene methylpolysiloxanes.

[0038] In the pesticide composition of the present invention, the lower limit of the amount of the active ingredient of the stigma sealant or silicone-based spreader relative to 1 part by weight of the calcium-activated potassium channel modulator is preferably 1 part by weight, more preferably 2 parts by weight, even more preferably 3 parts by weight, and even more preferably 5 parts by weight, and the upper limit is preferably 2,000 parts by weight, more preferably 100 parts by weight, even more preferably 50 parts by weight, even more preferably 40 parts by weight, even more preferably 33 parts by weight, and most preferably 29 parts by weight relative to 1 part by weight of the calcium-activated potassium channel modulator. The upper limit of the amount of the active ingredient of the stigma sealant or silicone-based spreader contained in the pesticide composition of the present invention is not particularly limited from the viewpoint of pest control, but the higher the amount of the active ingredient of an oil-based stigma sealant, the more likely it is that oil spots (oil stains) or darkening will occur when sprayed in a high-temperature environment, and the higher the amount of the active ingredient of a sugar-based stigma sealant or the active ingredient of a surfactant-based stigma sealant, the more likely it is that irritation to the crop epidermis will occur.

[0039] The total amount of the calcium-activated potassium channel modulator and the active ingredients of the stigma-sealing agent or silicone-based spreading agent contained in the pesticide composition of the present invention is not particularly limited, as long as it exhibits pest control effects. When applied, the pesticide composition of the present invention has a calcium-activated potassium channel modulator concentration limit of preferably 1 ppm, more preferably 5 ppm, and even more preferably 10 ppm, and an upper limit of 1000 ppm and more preferably 500 ppm. The active ingredients of the stigma-sealing agent or silicone-based spreading agent concentration limit of preferably 100 ppm, more preferably 150 ppm, and even more preferably 200 ppm, and an upper limit of preferably 5000 ppm, more preferably 2500 ppm, and even more preferably 2000 ppm. The concentration can be adjusted by dilution with water or the like.

[0040] The pesticide composition of the present invention can be prepared, for example, by mixing a calcium-activated potassium channel modulator with the active ingredients of a stigma blocker or a silicone-based spreader. A solvent can be used for the preparation. Examples of the solvent include organic solvents such as methanol, ethanol, isopropanol, propylene glycol, glycerin, and sorbitol, as well as mixtures of these solvents. Heating may be performed as appropriate to facilitate dissolution or suspension of the calcium-activated potassium channel modulator and the active ingredients of the stigma blocker or silicone-based spreader in the solvent. During the preparation, emulsifiers, dispersants, adjuvants, and the like known in the art can be added as appropriate.

[0041] The target to which the pest control composition of the present invention is applied is preferably plants such as grains, vegetables, root vegetables, potatoes, flowers, fruit trees, ornamental plants, trees such as tea, coffee, and cacao, pasture grasses, turf grasses, and cotton. When applied to plants, the pesticide composition of the present invention may be applied to any part of the plant, such as leaves, stems, stalks, flowers, buds, fruits, seeds, sprouts, roots, tubers, tuberous roots, shoots, and cuttings. Furthermore, the pesticide composition of the present invention is not particularly limited by the species of plant to which it is applied, and examples of plant species include original species, varieties, improved varieties, cultivated varieties, mutants, hybrids, genetically modified organisms (GMOs), etc.

[0042] The pesticide composition of the present invention can be used for seed treatment, foliage application, soil application, water surface application, etc. to control various agricultural pests and mites.

[0043] Specific examples of various agricultural pests and mites that can be controlled by the pesticide composition of the present invention are shown below.

[0044] (1) a butterfly or moth of the order Lepidoptera (a) Arctiidae moths, such as Hyphantria cunea and Lemyra imparilis; (b) Moths of the Bucculatricidae family, e.g., Bucculatrix pyrivorella; (c) Carposinidae, e.g., Carposina sasakii; (d) Crambidae moths, for example, Diaphania spp., such as Diaphania indica and Diaphania nitidalis; for example, Ostrinia spp., such as Ostrinia furnacalis, Ostrinia nubilalis, and Ostrinia scapulalis; and others, such as Chilo suppressalis, Cnaphalocrocis medinalis, Conogethes punctiferalis, Diatraea grandiosella, Glyphodes pyloalis, and Hellula undalis), Parapediasia teterrella; (e) Moths of the family Gelechiidae, such as the potato leaf moth (Helcystogramma triannulella), the red bollworm (Pectinophora gossypiella), the potato leaf moth (Phthorimaea operculella), and the potato moth (Sitotroga cerealella); (f) Moths of the Geometridae family, for example, Ascotis selenaria; (g) Moths of the Gracilariidae family, such as Caloptilia theivora, Phyllocnistis citrella, and Phyllonorycter ringoniella; (h) butterflies of the Hesperiidae family, e.g., Parnara guttata; (i) Lasiocampidae moths, e.g., Malacosoma neustria; (j) Lymantriidae moths, for example, Lymantria spp., Lymantria dispar, Lymantria monacha; others, Euproctis pseudoconspersa, Orgyia thyellina;

[0045] (k) Lyonetiidae moths, for example, Lyonetia spp., such as the peach leafminer (Lyonetia clerkella) and the silver leafminer (Lyonetia prunifoliella malinella); (l) Noctuidae moths, for example, Spodoptera spp., such as Spodoptera depravata, Spodoptera eridania, Spodoptera exigua, Spodoptera frugiperda, Spodoptera littoralis, and Spodoptera litura; for example, Autographa spp., such as Autographa gamma and Autographa nigrisigna; for example, Agrotis spp., such as Agrotis ipsilon and Agrotis nigrisigna. segetum; for example, Helicoverpa spp., such as Helicoverpa armigera, Helicoverpa assulta, and Helicoverpa zea; for example, Heliothis spp., such as Heliothis armigera and Heliothis virescens; and others, such as Aedialeucomelas, Ctenoplusia agnata, Eudocima tyrannus, Mamestra brassicae, Mythimna separata, Naranga aenescens, Panolis japonica, and Peridroma saucia), soybean looper (Pseudoplusia includens), nettle looper (Trichoplusia ni); (m) Moths of the Nolidae family, e.g., Earias insulana; (n) Butterflies of the family Pieridae, such as Pieris spp., Pieris brassicae, Pieris rapae crucivora; (o) Moths of the Plutellidae family, for example, Acrolepiopsis spp., such as Acrolepiopsis sapporensis and Acrolepiopsis suzukiella; and others, such as Plutella xylostella. (p) Moths of the Pyralidae family, such as Cadra cautella, Elasmopalpus lignosellus, Etiella zinckenella, and Galleria mellonella; (q) Moths of the family Sphingidae, e.g., Manduca spp., tomato hornworm (Manduca quinquemaculata), tobacco hornworm (Manduca sexta);

[0046] (r) Moths of the Stathmopodidae family, for example, the persimmon pulp moth ( Stathmopoda masinissa ); (s) Moths of the Tineidae family, e.g., Tinea translucens; (t) Tortricidae moths, for example, Adoxophyes spp., such as the smaller tea tortrix moth (Adoxophyes honmai) and the smaller apple tortrix moth (Adoxophyes orana); Archips spp., such as the apple tortrix moth (Archips breviplicanus) and the green leaf tortrix moth (Archips fuscocupreanus); and other moths, such as the spruce budworm moth (Choristoneura fumiferana), the codling moth (Cydia pomonella), the grapevine moth (Eupoecilia ambiguella), the pear fruit moth (Grapholitha molesta), the tea tortrix moth (Homona magnanima), the bean fruit moth (Leguminivora glycinivorella), and the bean leaf moth (Lobesia botrana), bean pea moth (Matsumuraeses phaseoli), springtail moth (Pandemis heparana), Japanese bush moth (Sparganothis pilleriana); (u) Moths of the Yponomeutidae family, such as the apple fruit moth (Argyresthia conjugella).

[0047] (2) Thysanoptera pests (a) Phlaeothripidae, e.g., Ponticulothrips diospyrosi; (b) From the family Thripidae, for example, from the genus Frankliniella, such as Frankliniella intonsa and Frankliniella occidentalis; from the genus Thrips, for example, Thrips palmi and Thrips tabaci; and others, such as Heliothrips haemorrhoidalis and Scirtothrips dorsalis.

[0048] (3) Hemiptera pests (A)Archaeorrhyncha (a) Delphacidae, for example, Laodelphax striatella, Nilaparvata lugens, Perkinsiella saccharicida, and Sogatella furcifera.

[0049] (B) Clypeorrhyncha (a) Cicadellidae, for example, Empoasca spp., such as potato leafhopper (Empoasca fabae), persimmon leafhopper (Empoasca nipponica), tea green leafhopper (Empoasca onukii), bean green leafhopper (Empoasca sakaii); and others, such as Arboridia apicalis, green long leafhopper (Balclutha saltuella), giant leafhopper (Epiacanthus stramineus), small leafhopper (Macrosteles striifrons), green rice leafhopper (Nephotettix cinctinceps).

[0050] (C) Heteroptera (a) Alydidae, e.g., Riptortus clavatus; (b) Coreidae, e.g., Cletus punctiger, Leptocorisa chinensis; (c) Lygaeidae, such as Blissus leucopterus, Cavelerius saccharivorus, and Togo hemipterus; (d) Miridae, such as the black-spotted rice bug (Halticus insularis), the rusty rice bug (Lygus lineolaris), the cotton freehopper (Psuedatomoscelis seriatus), the long-gray rice bug (Stenodema sibiricum), the red-striped rice bug (Stenotus rubrovittatus), and the rice beetle (Trigonotylus caelestialium);

[0051] (e) Pentatomidae, for example, Nezara spp., such as Nezara antennata and Nezara viridula; Eysarcoris spp., such as Eysarcoris aeneus, Eysarcoris lewisi, Eysarcoris ventralis, and other species of the genus Dolycoris, including Dolycoris baccarum, Eurydema rugosum, Glaucias subpunctatus, and Halyomorpha halys), striped stink bug (Piezodorus hybneri), brown-winged green bug (Plautia crossota), black rice bug (Scotinophora lurida); (f) Pyrrhocoridae, e.g., Dysdercus cingulatus; (g) Rhopalidae, e.g., Rhopalus msculatus; (h) Scutelleridae, e.g., Eurygaster integriceps; (i) Tingidae, for example, Stephanitis nashi.

[0052] (D) Sternorrhyncha (a) Adelgidae, e.g., Adelges laricis; (b) Aleyrodidae, such as Bemisia spp., including the silverleaf whitefly (Bemisia argentifolii) and the tobacco whitefly (Bemisia tabaci); and others, including the citrus spiny whitefly (Aleurocanthus spiniferus), the citrus whitefly (Dialeurodes citri), and the greenhouse whitefly (Trialeurodes vaporariorum). (c) Aphididae, for example, Aphis spp., such as the bean aphid Aphis craccivora, the black bean aphid Aphis fabae, the strawberry aphid Aphis forbesi, the cotton aphid Aphis gossypii, the European apple aphid Aphis pomi, the elderberry aphid Aphis sambuci, and the willow aphid Aphis spiraecola; for example, Rhopalosiphum spp., such as the corn aphid Rhopalosiphum maidis and the wheat aphid Rhopalosiphum padi; for example, Dysaphis spp., such as the plantain aphid Dysaphis plantaginea, Dysaphis radicola; for example, Macrosiphum spp., wheat aphids (Macrosiphum avenae), tulip aphids (Macrosiphum euphorbiae); for example, Myzus spp.) of the Japanese plum aphid (Myzus cerasi), green peach aphid (Myzus persicae), and Japanese burdock aphid (Myzus varians); and other insects such as the pea aphid (Acyrthosiphon pisum), potato aphid (Aulacorthum solani), strawberry aphid (Brachycaudus helichrysi), radish aphid (Brevicoryne brassicae), strawberry woolly aphid (Chaetosiphon fragaefolii), peach butterbur aphid (Hyalopterus pruni), lettuce aphid (Hyperomyzus lactucae), false radish aphid (Lipaphis erysimi), and broad bean aphid (Megoura viciae), wheat aphid (Metopolophium dirhodum), lettuce aphid (Nasonovia ribis-nigri), hop wart aphid (Phorodon humuli), wheat green aphid (Schizaphis graminum), wheat long-horn aphid (Sitobion avenae), and phyllocanth aphid (Toxoptera aurantii);.

[0053] (d) from the family Coccidae, for example, Ceroplastes spp., Ceroplastes ceriferus, Ceroplastes rubens; (e) Diaspididae, Pseudaulacaspis spp., such as Pseudaulacaspis pentagona and Pseudaulacaspis prunicola; Unaspis spp., such as Unaspis euonymi and Unaspis yanonensis; and others, such as Aonidiella aurantii, Comstockaspis perniciosa, Fiorinia theae, and Pseudaonidia paeoniae. (f) Margarodidae, e.g., Drosicha corpulenta, Icerya purchasi; (g) Phylloxeridae, e.g., the grape aphid (Viteus vitifolii); (h) Pseudococcidae, for example, Planococcus spp., such as Planococcus citri, Planococcus kuraunhiae; and others, such as Phenacoccus solani, Pseudococcus comstocki; (i) From the family Psyllidae, for example, from the genus Psylla, such as the apple psylla (Psylla mali) and the pear psylla (Psylla pyrisuga); and others, such as the citrus psylla (Diaphorina citri).

[0054] (4) Pests of the Polyphaga beetle suborder (a) Anobiidae, e.g., the cigarette beetle (Lasioderma serricorne); (b) Attelabidae, e.g., Byctiscus betulae, Rhynchites heros; (c) Bostrichidae, e.g., Lyctus brunneus; (d) Brentidae, e.g., sweet potato weevil (Cylas formicarius); (e) Buprestidae, e.g., the red-spotted jewel beetle (Agrilus sinuatus); (f) Cerambycidae, for example, Anoplophora malasiaca, Monochamus alternatus, Psacothea hilaris, and Xylotrechus pyrrhoderus; (g) from the family Chrysomelidae, for example, from the genus Bruchus, the pea weevil (Bruchus pisorum) and the broad bean weevil (Bruchus rufimanus); from the genus Diabrotica, for example, the northern corn rootworm (Diabrotica barberi), the southern corn rootworm (Diabrotica undecimpunctata), and the western corn rootworm (Diabrotica virgifera); from the genus Phyllotreta, for example, the flea beetle (Phyllotreta nemorum) and the striped flea beetle (Phyllotreta striolata); and others, such as the cucumber beetle (Aulacophora femoralis), the adzuki bean weevil (Callosobruchus chinensis), and the turtle beetle (Cassida nebulosa), Tensite leaf beetle (Chaetocnema concinna), Colorado potato beetle (Leptinotarsa ​​decemlineata), Rice leaf beetle (Oulema oryzae), Eggplant long-striped leaf beetle (Psylliodes angusticollis);

[0055] (h) Coccinellidae, for example, Epilachna spp., Epilachna varivestis, Epilachna vigintioctopunctata; (i) From the family Curculionidae, for example, from the genus Anthonomus, the boll weevil (Anthonomus grandis) and the pear weevil (Anthonomus pomorum); from the genus Sitophilus, for example, the granary weevil (Sitophilus granarius) and the maize weevil (Sitophilus zeamais); and other insects, such as the rice weevil (Echinocnemus squameus), the potato weevil (Euscepes postfasciatus), the pine weevil (Hylobius abietis), the alfalfa weevil (Hypera postica), the rice water weevil (Lissohoptrus oryzophilus), and the vine weevil (Otiorhynchus sulcatus), red-legged weevil (Sitona lineatus), grass weevil (Sphenophorus venatus); (j) Elateridae, for example, Melanotus spp., such as the yellow-striped click beetle (Melanotus fortnumi) and the yellow-striped click beetle (Melanotus tamsuyensis); (k) Nitidulidae, e.g., Epuraea domina; (l) Scarabaeidae, for example, Anomala spp., such as Anomala cuprea and Anomala rufocuprea; other beetles such as Cetonia aurata, Gametis jucunda, Heptophylla picea, Melolontha melolontha, and Popillia japonica; (m) of the Scolytidae family, e.g., Ips typographus; (n) Staphylinidae, e.g., Paederus fuscipes; (o) Tenebrionidae, e.g., Tenebrio molitor, Tribolium castaneum; (p) Of the Trogossitidae family, for example, the red widow (Tenebroides mauritanicus).

[0056] (5) Diptera pests (A) Flies (Brachycera) (a) Agromyzidae, for example, Liriomyza spp., such as Liriomyza bryoniae, Liriomyza chinensis, Liriomyza sativae, and Liriomyza trifolii; and others, such as Chromatomyia horticola and Agromyza oryzae. (b) Anthomyiidae, e.g., Delia spp., seed flies (Delia platura), cabbage flies (Delia radicum); and others, such as the beet root fly (Pegomya cunicularia). (c) Drosophilidae, e.g., Drosophila spp., Drosophila melanogaster, Drosophila suzukii; (d) Ephydridae, e.g., Hydrellia griseola; (e) of the family Psilidae, e.g., the carrot rust fly (Psila rosae); (f) From the family Tephritidae, for example, from the genus Bactrocera, for example, the melon fly (Bactrocera cucurbitae) and the oriental fruit fly (Bactrocera dorsalis); from the genus Rhagoletis, for example, the European cherry fruit fly (Rhagoletis cerasi) and the apple fruit fly (Rhagoletis pomonella); and others, for example, the Mediterranean fruit fly (Ceratitis capitata) and the olive fruit fly (Dacus oleae).

[0057] (B) Nematocera (a) Cecidomyiidae, for example, soybean pod gall midge (Asphondylia yushimai), sorghum gall midge (Contarinia sorghicola), Hessian fly (Mayetiola destructor), and wheat gall midge (Sitodiplosis mosellana).

[0058] (6) Orthoptera pests (a) From the grasshopper family (Acrididae), for example, from the genus Schistocerca, the American locust (Schistocerca americana) and the desert locust (Schistocerca gregaria); and others, such as the Australian bush locust (Chortoicetes terminifera), the Moroccan locust (Dociostaurus maroccanus), the migratory locust (Locusta migratoria), the brown locust (Locustana pardalina), the red bush locust (Nomadacris septemfasciata), and the oriental grasshopper (Oxya yezoensis); (b) Gryllidae, e.g., the European house cricket (Acheta domestica), the field cricket (Teleogryllus emma); (c) of the family Gryllotalpidae, e.g., the mole cricket (Gryllotalpa orientalis); (d) From the family Tettigoniidae, for example, the grasshopper (Tachycines asynamorus).

[0059] (7) Mites (Acari) (A) Acaridida mites of the order Astigmata (a) Mites of the family Acaridae, for example, Rhizoglyphus spp., such as Rhizoglyphus echinopus and Rhizoglyphus robini; for example, Tyrophagus spp., such as Tyrophagus neiswanderi, Tyrophagus perniciosus, Tyrophagus putrescentiae, and Tyrophagus similis; and others, such as Acarus siro, Aleuroglyphus ovatus, and Mycetoglyphus fungivorus.

[0060] (B) Prostigmata (Actinedida) (a) Mites of the family Tetranychidae, for example, Bryobia spp., such as clover spider mites (Bryobia praetiosa) and false clover spider mites (Bryobia rubrioculus); for example, Eotetranychus spp., such as Eotetranychus asiaticus, Eotetranychus boreus, Eotetranychus celtis, Eotetranychus geniculatus, Eotetranychus kankitus, Eotetranychus pruni, Eotetranychus shii, Eotetranychus smithi, Eotetranychus spp. suginamensis, Eotetranychus uncatus; for example, of the genus Oligonychus, such as Oligonychus hondoensis, Oligonychus ilicis, Oligonychus karamatus, Oligonychus mangiferus, Oligonychus orthius, Oligonychus perseae, Oligonychus pustulosus, Oligonychus shinkajii, Oligonychus ununguis; for example, of the genus Panonychus, such as Panonychus citri), Panonychus mori, Panonychus ulmi; e.g., Tetranychus spp.) such as Tetranychus cinnabarinus, Tetranychus evansi, Tetranychus kanzawai, Tetranychus ludeni, Tetranychus quercivorus, Tetranychus phaselus, Tetranychus urticae, Tetranychus viennensis; Aponychus spp., for example, Aponychus corpuzae, Aponychus firmianae; Sasanychus spp., for example, Sasanychus akitanus, Sasanychus pusillus; for example, Shizotetranychus spp., such as Shizotetranychus celarius, Shizotetranychus longus, Shizotetranychus miscanthi, Shizotetranychus recki, and Shizotetranychus schizopus; and others, such as Tetranychina harti, Tuckerella pavoniformis, and Yezonychus sapporensis.

[0061] (b) Mites of the Tenuipalpidae family, for example, Brevipalpus spp., such as the grape spider mite (Brevipalpus lewisi), the tea spider mite (Brevipalpus obovatus), the southern spider mite (Brevipalpus phoenicis), the cactus spider mite (Brevipalpus russulus), and the greenhouse spider mite (Brevipalpus californicus); for example, Tenuipalpus spp., such as the orchid spider mite (Tenuipalpus pacificus) and the oyster spider mite (Tenuipalpus zhizhilashviliae); and others, such as the pineapple spider mite (Dolichotetranychus floridanus). (c) Mites of the family Eriophyidae, for example, Aceria spp., such as Aceria diospyri, Aceria ficus, Aceria japonica, Aceria kuko, Aceria paradianthi, Aceria tiyingi, Aceria tulipae, and Aceria zoysiea; for example, Eriophyes spp., such as Eriophyes chibaensis and Eriophyes emarginatae; for example, Aculops spp., such as Aculops tomato. lycopersici, citrus rust mite (Aculops pelekassi); for example, Aculus spp., peach rust mite (Aculus fockeui), apple rust mite (Aculus schlechtendali); others, such as the tea long rust mite (Acaphylla theavagrans), tea rust mite (Calacarus carinatus), grape leafminer mite (Colomerus vitis), grape rust mite (Calepitrimerus vitis), pear rust mite (Epitrimerus pyri), sweetmeat rust mite (Paraphytoptus kikus), peach rust mite (Paracalacarus podocarpi), and Ryukyu citrus rust mite (Phyllocotruta citri); (d) Mites of the family Transonemidae, for example, Tarsonemus spp., such as Tarsonemus bilobatus and Tarsonemus waitei; others, such as Phytonemus pallidus and Polyphagotarsonemus latus; (e) Mites of the family Penthaleidae, for example, Penthaleus spp., such as Penthaleus erythrocephalus and Penthaleus major.

[0062] The pesticide composition of the present invention may be mixed or used in combination with other active ingredients, such as those contained in fungicides, insecticides / acaricides, nematicides, soil pesticides, etc.; and those contained in plant regulators, synergists, fertilizers, soil conditioners, animal feed, etc. The combination of the pesticide composition of the present invention with other active ingredients is expected to produce a synergistic effect in terms of insecticidal, acaricidal, and nematicidal activities. The synergistic effect can be confirmed by Colby's formula (Colby, SR; Calculating Synergistic and Antagonistic Responses of Herbicide Combinations; Weeds, 15, pp. 20-22, 1967) in accordance with a standard method.

[0063] Specific examples of active ingredients contained in insecticides, miticides, nematicides, soil pesticides, anthelmintics and the like that can be mixed or used in combination with the pest control composition of the present invention are shown below.

[0064] (1B) Acetylcholinesterase (AChE) inhibitors (organophosphates) Acephate, Azamethiphos, Azinphos-ethyl, Azinphos-methyl, Cadusafos, Chlorethoxyfos, Chlorfenvinphos, Chlormephos, Chlorpyrifos, Chlorpyrifos-methyl, Coumaphos, Cyanophos, Demeton-S-methyl, Diazinon, Dichlorvos DDVP), Dicrotophos, Dimethoate, Dimethylvinphos, Disulfoton, EPN, Ethion, Ethoprophos, Famphur, Fenamiphos, Fenitrothion, Fenthion, Fosthiazate, Heptenophos, Imicyafos, Isofenphos, Isopropyl O-(methoxyaminothio-phosphoryl) salicylatesalicylate, Isoxathion, Malathion, Mecarbam, Methamidophos, Methidathion, Mevinphos, Monocrotophos, Naled, Omethoate, Oxydemeton-methyl, Parathion, Parathion-methyl, Phenthoate, Phorate, Phosalone, Phosmet, Phosphamidon, Phoxim, Pirimiphos-methyl methyl), profenofos, propetamphos, prothiofos, pyraclofos, pyridaphenthion, quinalphos, sulfotep, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, trichlorfon, vamidothion. Bromophos-ethyl, Cyanofenphos, Demeton-S-methylsulfone, Dialifos, Dichlofenthion, Dioxabenzofos, Etrimfos, Fensulfothion, Fonofos, Formothion, Iodofenphos, Isazofos, Isocarbofos, Methacrifos, Phosphocarb, Pirimiphos-ethyl, Propaphos, Prothoate, Sulprofos.

[0065] (2) GABAergic chloride channel blockers Chlordane, Endosulfan; Ethiprole, Fipronil. Acetoprole, Camphechlor, Dienochlor, Heptachlor, Pyrafluprole, Pyriprole; Flufiprole.

[0066] (3A) Sodium channel modulators (pyrethroids) Acrinathrin, Allethrin, d-cis-trans-Allethrin, d-trans-Allethrin, Bifenthrin, Bioallethrin, Bioallethrin-S-cyclopentenyl-isomer S-cyclopentenyl-isomer, Bioresmethrin, Cycloprothrin, Cyfluthrin, β-Cyfluthrin, Cyhalothrin, λ-Cyhalothrin, γ-Cyhalothrin, Cypermethrin, α-Cypermethrin, β-Cypermethrin, theta-Cypermethrin, ζ-Cypermethrin, Cyphenothrin [(1R)-trans-isomers] ), Deltamethrin, Empenthrin [(EZ)-(1R)-isomers], Esfenvalerate, Etofenprox, Fenpropathrin, Fenvalerate, Flucythrinate, Flumethrin, tau-Fluvalinate, Halfenprox, Imiprothrin, Kadethrin, Permethrin, Phenothrin [(1R)-trans-isomer]), Prallethrin, Pyrethrins, Resmethrin, Silafluofen, Tefluthrin, Tetramethrin, Tetramethrin [(1R)-isomers], Tralomethrin, Transfluthrin. κ-Bifenthrin, Biopermethrin, Chloroprallethrin, Dimefluthrin, Fenfluthrin, Fenpirithrin, Flufenprox, Heptafluthrin, Meperfluthrin, ε-Metofluthrin ), Momfluorothrin, epsilon-Momfluorothrin, trans-Permethrin, Profluthrin, Protrifenbute, kappa-Tefluthrin, Terallethrin, Tetramethylfluthrin; Bioethanomethrin. (3B) Sodium channel modulators (DDTs) DDT, Methoxychlor.

[0067] (4) Nicotinic acetylcholine receptor (nAChR) competitive modulators Acetamiprid, Clothianidin, Dinotefuran, Imidacloprid, Nitenpyram, Thiacloprid, Thiamethoxam; Nicotine; Sulfoxaflor; Flupyradifurone; Triflumezopyrim. Nithiazine; Dichloromezotiaz, Flupyrimin. (5) Nicotinic acetylcholine receptor (nAChR) allosteric modulators Spinetoram, Spinosad. (6) Glutamate-gated chloride channel (GluCl) allosteric modulators Abamectin, Emamectin, Emamectin-benzoate, Lepimectin, Milbemectin. Doramectin, Eprinomectin, Ivermectin, Moxidectin, Selamectin.

[0068] (7) Juvenile hormone analogues Hydroprene, Kinoprene, Methoprene ;Fenoxycarb;Pyriproxifen. Diofenolan, Epophenonane, Triprene. (8) Other nonspecific (multi-site) inhibitors Methyl bromide, alkyl halides; chloropicrin; sodium aluminum fluoride, sulfuryl fluoride; borax, boric acid, disodium octaborate, sodium borate, sodium metaborate; tartar emetic; dazomet, metam, metam sodium, metam potassium. (9) Chordotonal organ TRPV channel modulators Pymetrozine, Pyrifluquinazon; Afidopyropen. (10) Mite growth inhibitor Clofentezine, Diflovidazin, Hexythiazox; Etoxazole.

[0069] (11) Microbial-derived insect midgut membrane disrupting agents Bt subsp. israelensis, Bt subsp. aizawai, Bt subsp. kurstaki, Bt subsp. tenebrionis; Bt crop proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry1A.105, Cry2Ab, Vip3A, mCry3A, Cry3Ab, Cry3Bb, Cry34Ab1 / Cry35Ab1; Bacillus sphaericus. (12) Mitochondrial ATP synthase inhibitors Diafenthiuron; Azocyclotin, Cyhexatin, Fenbutatin-oxide; Propargite; Tetradifon. (13) Oxidative phosphorylation uncouplers that disrupt proton gradients Chlorfenapyr, DNOC (4,6-dinitro-o-cresol), sulfluramid. Binapacryl, Dinobuton, Dinocap. (14) Nicotinic acetylcholine receptor (nAChR) channel blockers Bensultap, Cartap hydrochloride, Thiocyclam, Thiosultap-sodium.

[0070] (15) Chitin biosynthesis inhibitor, type 0 Bistrifluron, Chlorfluazuron, Diflubenzuron, Flucycloxuron, Flufenoxuron, Hexaflumuron, Lufenuron, Novaluron, Noviflumuron, Teflubenzuron, Triflumuron. Fluazuron. (16) Chitin biosynthesis inhibitor, type 1 Buprofezin. (17) Molting inhibitor Cyromazine. (18) Ecdysone receptor agonist Chromafenozide, Halofenozide, Methoxyfenozide, Tebufenozide.

[0071] (19) Octopamine receptor agonists Amitraz. Chlordimeform. (20) Mitochondrial electron transport chain complex III inhibitor Hydramethylnon; Acequinocyl; Fluacrypyrim; Bifenazate. (21) Mitochondrial electron transport complex I inhibitor (METI) Fenazaquin, Fenpyroximate, Pyridaben, Pyrimidifen, Tebufenpyrad, Tolfenpyrad; Rotenone. (22) Voltage-dependent sodium channel blockers Indoxacarb; Metaflumizone. (23) Acetyl-CoA carboxylase inhibitors Spirodiclofen, Spiromesifen, Spirotetramat. Spiropidione. (24) Mitochondrial electron transport chain complex IV inhibitor Aluminum phosphide (Al-phosphide), calcium phosphide (Ca-phosphide), zinc phosphide (Zn-phosphide), phosphine; calcium cyanide (Ca-cyanide), sodium cyanide (Na-cyanide), potassium cyanide (K-cyanide). (25) Mitochondrial electron transport chain complex II inhibitor Cyenopyrafen, Cyflumetofen; Pyflubumide.

[0072] (28) Ryanodine receptor modulators Chlorantraniliprole, Cyantraniliprole, Cyclaniliprole, Flubendiamide. Cyhalodiamide, Tetrachlorantraniliprole, Tetraniliprole. (29) Chord tone organ modulator target region unspecified Flonicamid. (30) GABA-gated chloride channel allosteric modulators Broflanilide, Fluxametamide. Isocycloseram; Afoxolaner, Fluralaner, Lotilaner, Sarolaner.

[0073] (31) Other insecticides and acaricides Azadirachtin, Benzoximate, Bromopropylate, Chinomethionate, Dicofol, Lime sulfur, Mancozeb, Pyridalyl, Sulfur. Amidoflumet, Benzomate, Benzpyrimoxan, Chlorobenzilate, Dicyclanil, Fenoxacrim, Fentrifanil, Flometoquin, Flubenzimine, Flufenzine, Fluhexafon, Fluopyram, Metaflumizone, Metoxadiazone, Oxazosulfyl, Tetrasul, Triarathene, Tyclopyrazoflor.

[0074] Specific examples of active ingredients contained in anthelmintics that can be mixed or used in combination with the pesticide composition of the present invention are shown below. (a) Benzimidazoles: fenbendazole, albendazole, triclabendazole, oxibendazole, mebendazole, oxfendazole, perbendazole, flubendazole; febantel, netobimin, thiophanate; thiabendazole, cambindazole; (b) Salicylanilides: closantel, oxyclozanide, rafoxanide, niclosamide; (c) Substituted phenols: nitroxynil, nitroscate; (d) Pyrimidines: pyrantel, morantel; (e) Imidazothiazoles: levamisole, tetramisole; (f) Tetrahydropyrimidines: praziquantel, epsiprantel; (g) Other anthelmintics: cyclodiene, ryania, clorsulon, metronidazole, demiditraz; piperazine, diethylcarbamazine, dichlorophen, monepantel, tribendimidine, amidantel; thiacetarsamide, melarsamine, arsenamide.

[0075] Specific examples of active ingredients contained in fungicides that can be mixed or used in combination with the pesticide composition of the present invention are shown below. (A) Inhibitors of nucleic acid synthesis metabolism A1) RNA polymerase I inhibitors Benalaxyl, benalaxyl-M, furalaxyl, metalaxyl, metalaxyl-M; oxadixyl; ofurace. A2) Adenosine deaminase inhibitors Bupirimate, dimethirimol, ethirimol. A3) DNA / RNA biosynthesis inhibitors Hymexazole, octhilinone. A4) DNA topoisomerase type II inhibitors Oxolinic acid.

[0076] (B) Agents acting on the cytoskeleton and motor proteins B1)~B3) Inhibition of β-tubulin polymerization Benomyl, carbendazim, fuberidazole, thiabendazole, thiophanate, thiophanate-methyl, diethofencarb, zoxamide, Ethaboxam. Chlorfenazole, debacarb, trichlamide, zarilamid. B4) Cell division (point of action unknown) Pencycuron. B5) Delocalization of spectrin-like proteins Fluopicolide, fluopimomide. B6) Actin / myosin / fimbrin functions Phenamacril, metrafenone, pyriophenone.

[0077] (C) Respiratory inhibitors C1) Complex I: NADH oxidoreductase Diflumetorim, tolfenpyrad, fenazaquin. C2) Complex II: succinate dehydrogenase benodanil, flutolanil, mepronil; Isofetamide; fluopyram; cyclobutrifluram; fenfuram; carboxin, oxycarboxin; thifluzamide; benzovindiflupyr, bixafen, fluindapyr, fluxapyroxad, furametpyr, inpyrfluxam, isopyrazam, penflufen, penthiopyrad, sedaxane; isofleucipram; pydiflumetofen; boscalid; pyraziflumid. Furmecyclox. C3) Complex III: cytochrome bc1 (ubiquinol oxidase) Qo site (cyt b gene) Azoxystrobin, coumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin; mandestrobin (mandestrobin); pyraclostrobin, pyrametostrobin, triclopyricarb; kresoxim-methyl, trifloxystrobin; dimoxystrobin, fenaminstrobin, metominostrobin, orysastrobin; famoxadone; fluoxastrobin; fenamidone; pyribencarb; methyltetraprole. C4) Complex III: Ubiquinone reductase Qi site Cyazofamid; amisulbrom; fenpicoxamid, florylpicoxamid. C5) Uncoupling of oxidative phosphorylation Binapacryl, dinocap, meptyldinocap; fluazinam. C6) Inhibition of oxidative phosphorylation and ATP synthase Triphenyltin acetate, triphenyltin chloride, fentin hydroxide. C7) ATP transport Silthiofam. C8) Complex III: ubiquinone reductase (Qo site, stigmatellin-binding subsite) Ametoctradin.

[0078] (D) Inhibitors of amino acid and protein synthesis D1) Methionine biosynthesis (cgs gene) Cyprodinil, mepanipyrim, pyrimethanil. D2) Protein synthesis (ribosome translation termination stage) Blasticidin S D3), ​​D4) Protein synthesis (ribosome translation initiation stage) Kasugamycin, kasugamycin hydrochloride, streptomycin. D5) Protein synthesis (ribosomal polypeptide elongation step) Oxytetracycline.

[0079] (E) Signal transduction inhibitors E1) Signal transduction (mechanism of action unknown) Quinoxyfen, proquinazid. E2) MAP / histidine kinase (os-2, HOG1) in osmotic signaling Fenpiclonil, fludioxonil. E3) MAP / histidine kinase (os-1, Daf1) in osmotic signaling Chlozolinate, dimethachlone, iprodione, procymidone, vinclozolin.

[0080] (F) Agents that inhibit lipid biosynthesis or transport / cell membrane structure or function F2) Phospholipid biosynthesis, methyltransferase Edifenphos, iprobenfos, pyrazophos; isoprothiolane. F3) Cellular peroxidation Biphenyl, chloroneb, dicloran, quintozene, tecnazene, tolclofos-methyl; etridiazole. F4) Cell membrane permeability, fatty acids Iodocarb, propamocarb, propamocarb hydrochloride, prothiocarb. F8) Ergosterol bond Natamycin. F9) Lipid homeostasis and transport / storage Oxathiapiprolin, fluoxapiprolin.

[0081] (G) Inhibitors of sterol biosynthesis in the plasma membrane G1) C14 demethylase of sterol biosynthesis (erg11 / cyp51) Triforine, pyrifenox, pyrisoxazole, fenarimol, nuarimol, imazalil, oxpoconazole, pefurazoate, prochloraz, triflumizole, azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole Fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, mefentrifluconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, and prothioconazole. Fluconazole, furconazole-cis, diniconazole-M. G2) Δ14 reductase and Δ8→Δ7-isomerase (erg24, erg2) in sterol biosynthesis Aldimorph, dodemorph, dodemorph acetate, fenpropimorph, tridemorph; fenpropidin, piperalin; spiroxamine. Buthiobate. G3) 3-ketoreductase (erg27) in the C4 demethylation of sterol biosynthesis Fenhexamid; fenpyrazamine. G4) Squalene epoxidase (erg1) of the sterol biosynthesis pathway Pyributicarb; naftifine, terbinafine.

[0082] (H) Inhibitors of cell wall biosynthesis H4) Chitin synthase Polyoxin. Polyoxorim. H5) Cellulose synthase Dimethomorph, flumorph, pyrimorph ; Benthiavalicarb, iprovalicarb, valifenalate; mandipropamid.

[0083] (I) Inhibitor of cell wall melanin synthesis I1) Reductases of melanin biosynthesis Fthalide; pyroquilon; tricyclazole. I2) Dehydratase of melanin biosynthesis Carpropamid; diclocymet; fenoxanil. I3) Polyketide synthase in melanin biosynthesis Tolprocarb.

[0084] (P) Agents that induce resistance in host plants P1-P3) Salicylic Acid Signaling Acibenzolar-S-methyl; probenazole; tiadinil, isotianil. P4) Polysaccharide elicitor Laminarin. P5) Anthraquinone elicitor Giant knotweed extract (extract from Reynoutria sachalinensis). P6) Microbial elicitors Bacillus mycoides isolate J; cell walls of Saccharomyces cerevisiae strain LAS117. P7) Phosphonate Fosetyl (fosetyl-Al); phosphorous acid and salts; fosetyl calcium (fosetyl-K), fosetyl sodium (fosetyl-Na). P8) Salicylic acid-related Dichlobentiazox

[0085] (U) Agents with unknown mechanism of action Cymoxanil; tecloftalam; triazoxide; flusulfamide; diclomezine; cyflufenamid; dodine, dodine free base; flutianil; ferimzone; tebufloquin; picarbutrazox; validamycin. bethoxazin, cyprofuram, flumetover, Nitrothal-isopropyl, propamidine. Ipflufenoquin, pyridaclomethyl, pyrapropoyne, aminopyrifen, ipfentrifluconazole, quinofumelin, dipymetitrone.

[0086] (M) Agents exhibiting multisite contact activity Copper (different salts), basic copper sulfate, Bordeaux mixture, copper hydroxide, copper naphthenate, copper oxychloride, copper sulfate, cuprous oxide, oxine-copper; sulfur, lime sulfur; amobam, ferbam, mancozeb, maneb, metiram, propineb, thiuram, zinc thiazole Thiazole, zineb, ziram; captan, captafol, folpet; chlorothalonil; dichlofluanid, tolylfluanid; guazatine, guazatine acetates, iminoctadine, iminoctadine acetate, iminoctadine triacetate, iminoctadine tribesilate; anilazine; dithianon; chinomethionate; fluoroimide; methasulfocarb. Dazomet, cufraneb, mancopper, polycarbamate.

[0087] (BM01) Biological pesticides with multiple modes of action / biologically derived pesticides Extract from the cotyledons of lupine plantlets; extract from Swinglea glutinosa; extract from Melaleuca alternifolia (tea tree oil); plant oils (mixtures): eugenol, geraniol, thymol.

[0088] (BM02) Multi-mode biopesticides / biological pesticides Trichoderma atroviride strain I-1237, Trichoderma atroviride strain LU132, Trichoderma atroviride strain SC1, Trichoderma atroviride strain SKT-1, Trichoderma atroviride strain 77B; Trichoderma asperellum strain T34, Trichoderma asperellum strain kd; Trichoderma harzianum strain T-22; Trichoderma virens strain G-41; Gliocladium catenulatum strain J1446; Clonostachys rosea strain CR-7; Coniothyrium minitans strain CON / M / 91-08; Talaromyces flavus strain SAY-Y-94-01; Saccharomyces cerevisiae strain LAS02; Bacillus amyloliquefaciens strain QST713, Bacillus amyloliquefaciens strain FZB24, Bacillus amyloliquefaciens strain MBI600, Bacillus amyloliquefaciens strain D747, Bacillus amyloliquefaciens strain F727, Bacillus amyloliquefaciens strain AT-332; Bacillus subtilis strain AFS032321, Bacillus subtilis strain Y1336, Bacillus subtilis strain HAI-0404; Pseudomonas chlororaphis strain AFS009; Streptomyces griseovirides strain K61; Streptomyces lydicus strain WYEC108. (NC) Unclassified ingredients Mineral oils, organic oils, inorganic salts, material of biological origin.

[0089] Specific examples of active ingredients contained in plant regulators that can be mixed or used in combination with the pesticide composition of the present invention are shown below. Abscisic acid, kinetin, benzylaminopurine, 1,3-diphenylurea, forchlorfenuron, thidiazuron, chlorfenuron, dihydrozeatin, gibberellin A, gibberellin A4, gibberellin A7, gibberellin A3, 1-methylcyclopropane, N-acetylaminoethoxyvinylglycine (also known as abiglycine), aminooxyacetic acid, silver nitrate, cobalt chloride, IAA, 4-CPA, cloprop, 2,4-D, MCPB, indole-3-butyric acid, dichlorprop, fu Thiol, 1-naphthylacetamide, ethychlozate, cloxifonac, maleic hydrazide, 2,3,5-triiodobenzoic acid, salicylic acid, methyl salicylate, (-)-jasmonic acid, methyl jasmonate, (+)-strigol, (+)-deoxystrigol, (+)-orobanchol, (+)-sorgolactone, 4-oxo-4-(2-phenylethyl)aminobutyric acid; ethephon, chlormequat, mepiquat chloride, benzyladenine, 5-aminolevulinic acid.

[0090] The pesticide composition of the present invention can be used to control ectoparasites.The host animals that are the targets of the pesticide composition of the present invention for the control of ectoparasites include warm-blooded animals such as humans, domestic mammals (e.g., cattle, horses, pigs, sheep, goats, etc.), laboratory animals (e.g., mice, rats, gerbils, etc.), pet animals (e.g., hamsters, guinea pigs, dogs, cats, horses, squirrels, rabbits, ferrets, etc.), wild and zoo mammals (monkeys, foxes, deer, buffalo, etc.), poultry (turkeys, ducks, chickens, quails, geese, etc.), pet birds (pigeons, parrots, mynah birds, Java sparrows, parakeets, Bengalese finches, canaries, etc.); or fish such as salmon, trout, and koi carp.Other examples include honeybees, stag beetles, and rhinoceros beetles.

[0091] The pesticide composition of the present invention can be applied to animals for the control of ectoparasites by known veterinary methods (topical, oral, parenteral, or subcutaneous administration). Examples of such methods include oral administration to animals via tablets, capsules, or incorporation into feed; administration to animals via immersion, suppository, or injection (intramuscular, subcutaneous, intravenous, intraperitoneal, etc.); topical administration of an oily or aqueous liquid formulation via spraying, pour-on, or spot-on; kneading the pesticide composition of the present invention into a resin, molding the kneaded product into a suitable shape such as a collar or ear tag, and then attaching the kneaded product to an animal for topical administration; Examples include:

[0092] Ectoparasites parasitize in and on host animals, particularly warm-blooded animals. Specifically, they infest the back, armpits, lower abdomen, inner thighs, etc. of the host animal and survive by obtaining nutrients such as blood and dander from the animal. Examples of ectoparasites include mites, lice, fleas, mosquitoes, stable flies, and flesh flies. Specific examples of ectoparasites that can be controlled by the ectoparasite control agent of the present invention are shown below.

[0093] (1) Mites (Acari) Mites that parasitize insects, such as mites of the Dermanyssidae family, Macronyssidae family, Laelapidae family, Varroidae family, Argasidae family, Ixodidae family, Psoroptidae family, Sarcoptidae family, Knemidokoptidae family, Demodixidae family, Trombiculidae family, and stag beetle species. (2) Phthiraptera: Lice of the family Haematopinidae, lice of the family Linognathidae, lice of the family Menoponidae, lice of the family Philopteridae, and lice of the family Trichodectidae. (3) Siphonaptera Fleas of the family Pulicidae, for example, Ctenocephalides spp., dog flea (Ctenocephalides canis), cat flea (Ctenocephalides felis); Fleas of the Tungidae family, fleas of the Ceratophyllidae family, and fleas of the Leptopsyllidae family. (4) Hemiptera. (5) Diptera pests Mosquitoes of the Culicidae family, black flies of the Simuliidae family, midges of the Ceratopogonidae family, horseflies of the Tabanidae family, flies of the Muscidae family, sheathe flies of the Glossinidae family, flesh flies of the Sarcophagidae family, flies of the Hippoboscidae family, flies of the Calliphoridae family, and flies of the Oestridae family.

[0094] The pesticide composition of the present invention can be used to control or exterminate endoparasites. Parasites that are the target of the control or extermination treatment of endoparasites using the pesticide composition of the present invention are parasitic inside host animals, particularly warm-blooded animals and fish (endoparasites). The host animals for which the pesticide composition of the present invention is effective include warm-blooded animals such as humans, domestic mammals (e.g., cattle, horses, pigs, sheep, goats, etc.), laboratory animals (e.g., mice, rats, gerbils, etc.), pet animals (e.g., hamsters, guinea pigs, dogs, cats, horses, squirrels, rabbits, ferrets, etc.), wild and zoo mammals (monkeys, foxes, deer, buffalo, etc.), poultry (turkeys, ducks, chickens, quails, geese, etc.), pet birds (pigeons, parrots, mynah birds, Java sparrows, parakeets, Bengalese finches, canaries, etc.); or fish such as salmon, trout, and koi carp. Controlling and eliminating parasites can prevent or treat parasitic diseases transmitted by parasites.

[0095] Parasites to be controlled or eradicated include the following: (1) Dioctophymatida nematodes (a) Kidney worms of the family Dioctophymatidae, e.g., Dioctophyma spp., Dioctophyma renale; (b) Kidneyworms of the family Soboliphymatidae, for example, Soboliphyme spp., Soboliphyme abei, Soboliphyme baturini.

[0096] (2) Nematodes of the order Trichocephalidae (a) Trichinella of the family Trichinellidae, such as Trichinella spiralis of the genus Trichinella spp.; (b) whipworms of the Trichuridae family, for example, Capillaria spp., such as Capillaria annulata, Capillaria contorta, Capillaria hepatica, Capillaria perforans, Capillaria plica, and Capillaria suis; Trichuris spp., such as Trichuris vulpis, Trichuris discolor, Trichuris ovis, Trichuris skrjabini, and Trichuris suis.

[0097] (3) Rhabditida nematodes Strongyloides of the family Strongyloididae, for example, Strongyloides spp., Strongyloides papillosus, Strongyloides planiceps, Strongyloides ransomi, Strongyloides suis, Strongyloides stercoralis, Strongyloides tumefaciens, and Strongyloides ratti.

[0098] (4) Strongylida nematodes Hookworms of the family Ancylostomatidae, for example, from the genus Ancylostoma (Ancylostoma spp.), Ancylostoma braziliense, Ancylostoma caninum, Ancylostoma duodenale, Ancylostoma tubaeforme; from the genus Uncinaria (Uncinaria stenocephala), Uncinaria stenocephala; from the genus Bunostomum (Bunostomum phlebotomum), Bunostomum trigonocephalum.

[0099] (5) Strongylida nematodes (a) Nematodes of the family Angiostrongylidae, for example, Aelurostrongylus spp., cat lungworm (Aelurostrongylus abstrusus); Angiostrongylus spp., Angiostrongylus vasorum, Angiostrongylus cantonesis; (b) Nematodes of the Crenosomatidae family, e.g., Crenosoma spp., Crenosoma aerophila, Crenosoma vulpis; (c) nematodes of the family Filaroididae, e.g., Filaroides spp., dog lungworm (Filaroides hirthi), Filaroides osleri; (d) lungworms of the family Metastrongylidae, for example, Metastrongylus spp., Metastrongylus apri, Metastrongylus asymmetricus, Metastrongylus pudendotectus, and Metastrongylus salmi; (e) Open-beaked worms of the Syngamidae family, for example, Cyathostoma spp., such as the waterfowl lungworm (Cyathostoma bronchialis); Syngamus spp., such as the scrijabinomorpha and the chicken open-beaked worm (Syngamus trachea).

[0100] (6) Strongylida nematodes (a) Nematodes of the family Molineidae, e.g., Nematodirus spp., Nematodirus filicollis, Nematodirus spathiger; (b) Nematodes of the family Dictyocaulidae, e.g., Dictyocaulus spp., Dictyocaulus filaria, Dictyocaulus viviparus; (c) Nematodes of the family Haemonchidae, for example, Haemonchus spp., Haemonchus contortus; Mecistocirrus spp., Mecistocirrus digitatus; (d) Nematodes of the family Haemonchidae, for example, Ostertagia spp., Ostertagia ostertagi; (e) Nematodes of the family Heligmonellidae, for example, Nippostrongylus spp., rat strongyle (Nippostrongylus braziliensis); (f) Nematodes of the Trichostrongylidae family, for example, Trichostrongylus spp., such as Trichostrongylus axei, Trichostrongylus colubriformis, and Trichostrongylus tenuis; Hyostrongylus spp., such as Hyostrongylus rubidus; and Obeliscoides spp., such as Obeliscoides cuniculi.

[0101] (7) Strongylida nematodes (a) Nematodes of the Chabertiidae family, for example, Chabertia spp., such as the sheep nematode Chabertia ovina; Oesophagostomum spp., such as Oesophagostomum brevicaudatum, Oesophagostomum columbianum, Oesophagostomum dentatum, Oesophagostomum georgianum, Oesophagostomum maplestonei, Oesophagostomum quadrispinulatum, Oesophagostomum radiatum, Oesophagostomum venulosum, and Oesophagostomum scrofa. watanabei); (b) Nematodes of the family Stephanuridae, e.g., Stephanurus spp., pig kidney worm (Stephanurus dentatus); (c) Nematodes of the Strongylidae family, for example, Strongylus spp., such as the donkey strongyle (Strongylus asini), the toothless strongyle (Strongylus edentatus), the horse strongyle (Strongylus equinus), and the common strongyle (Strongylus vulgaris).

[0102] (8) Nematodes of the order Oxyurida Nematodes of the family Oxyuridae, for example, Enterobius spp., chimpanzee pinworm (Enterobius anthropopitheci), pinworm (Enterobius vermicularis); Oxyuris spp., horse pinworms (Oxyuris equi); Passalurus spp., rabbit pinworms (Passalurus ambiguus).

[0103] (9) Nematodes of the order Ascaridida (a) Nematodes of the family Ascaridiidae, for example, Ascaridia spp., Ascaridia galli; (b) Nematodes of the family Heterakidae, such as Heterakis spp., Heterakis beramporia, Heterakis brevispiculum, Heterakis gallinarum, Heterakis pusilla, and Heterakis putaustralis; (c) Nematodes of the family Anisakidae, e.g., Anisakis spp., Anisakis simplex; (d) Nematodes of the family Ascarididae, for example, Ascaris spp., human roundworm (Ascaris lumbricoides), pig roundworm (Ascaris suum); Parascaris spp., horse roundworm (Parascaris equorum); (e) Nematodes of the family Toxocaridae, for example, Toxocara spp., such as Toxocara canis, Toxocara leonina, Toxocarasuum, Toxocara vitulorum, and Toxocara cati.

[0104] (10) Nematodes of the order Spirurida (a) Nematodes of the family Onchocercidae, for example, Brugia spp., such as Brugia malayi, Brugia pahangi, and Brugia patei; Dipetalonema spp., such as Dipetalonema reconditum; Dirofilaria spp., such as Dirofilaria immitis; Filaria spp., such as Filaria oculi; Onchocerca spp., such as Onchocerca cervicalis and Onchocerca gibsoni), pharyngeal heartworm (Onchocerca gutturosa); (b) Nematodes of the Setariidae family, for example, Setaria spp., such as Setaria digitata, Setaria equina, Setaria labiatopapillosa, and Setaria marshalli; Wuchereria spp., such as Wuchereria bancrofti; (c) Nematodes of the family Filariidae, for example, Parafilaria spp., such as Parafilaria multipapillosa; Stephanofilaria spp., such as Stephanofilaria assamensis, Stephanofilaria dedoesi, Stephanofilaria kaeli, Stephanofilaria okinawaensis, and Stephanofilaria stilesi.

[0105] (11) Nematodes of the order Spirurida (a) Nematodes of the family Gnathostomatidae, e.g., Gnathostoma spp., Gnathostoma doloresi, Gnathostoma spinigerum; (b) Nematodes of the family Habronematidae, for example, Habronema spp., such as Habronema majus, Habronema microstoma, and Habronema muscae; Draschia spp., such as Draschia megastoma; (c) Nematodes of the family Physalopteridae, for example, Physaloptera spp., such as Physaloptera canis, Physaloptera cesticillata, Physaloptera erdocyona, Physaloptera felidis, Physaloptera gemina, Physaloptera papilloradiata, Physaloptera praeputialis, Physaloptera pseudopraerutialis, Physaloptera rara, and Physaloptera sibirica. sibirica), Physaloptera vulpineus; (d) Nematodes of the family Gongylonematidae, e.g., Gongylonema spp., Gongylonema pulchrum; (e) Nematodes of the family Spirocercidae, e.g., Ascarops spp., Ascarops strongylina; (f) Nematodes of the family Thelaziidae, for example, Thelazia spp., such as Thelazia callipaeda, Thelazia gulosa, Thelazia lacrymalis, Thelazia rhodesi, and Thelazia skrjabini.

[0106] The pest control composition of the present invention can also be used to control pests that have poisonous stingers or venom and cause harm to humans and animals, pests that transmit various pathogens and pathogenic bacteria, and pests that cause discomfort to humans (poisonous pests, sanitary pests, nuisance pests, etc.).

[0107] A specific example is given below. (1) Hymenoptera pests Wasps of the Argidae family, Cynipidae family, Diprionidae family, Formicidae family, Mutillidae family, and Vespidae family.

[0108] (2) Other pests Cockroaches (Blattodea), termites (termite), spiders (Araneae), centipedes (cetipede), millipedes (millipede), crustaceans (crustacea), bedbugs (Cimex lectularius).

[0109] The pesticide composition of the present invention can be formulated. The pesticide composition of the present invention is not particularly limited by the formulation type. For example, the formulation types include dusts (DP, dustable powder), wettable powders (WP, wattable powder), emulsifiable concentrates (EC, emulsifiable concentrates), flowables (FL, flowable), suspension concentrates (SC, suspension concentrates), water-soluble powders (SP, water-soluble powders), water-dispersible granules (WG, water-dispersible granules), tablets, granules (GR, granules), SE (suspension emulsions), OD (oil dispersions), and EW (emulsion oil in water) formulations. The formulation method is not particularly limited, and known methods can be used depending on the formulation type.

[0110] Some formulation examples of the pesticide composition of the present invention are shown below, but the additives and their addition ratios should not be limited to the formulations of these formulation examples and can be varied over a wide range. The parts in the formulations indicate parts by weight. The number of parts in the pesticide composition of the present invention refers to the total amount of the active ingredients of the calcium-activated potassium channel modulator and the stigma-blocking agent or silicone-based spreading agent.

[0111] The formulations for agricultural and horticultural use and for paddy rice are shown below. (Formulation 1: Wettable powder) 40 parts of the pesticide composition of the present invention, 53 parts of diatomaceous earth, 4 parts of higher alcohol sulfate, and 3 parts of alkylnaphthalene sulfonate are uniformly mixed and finely pulverized to obtain a wettable powder containing 40% of the active ingredient. (Formulation 2: emulsion) 30 parts of the pesticide composition of the present invention, 33 parts of xylene, 30 parts of dimethylformamide, and 7 parts of polyoxyethylene alkyl allyl ether are mixed and dissolved to obtain an emulsifiable concentrate containing 30% of the active ingredient. (Formulation 3: Granules) Five parts of the pesticide composition of the present invention, 40 parts of talc, 38 parts of clay, 10 parts of bentonite, and 7 parts of sodium alkyl sulfate are uniformly mixed and finely ground, and then granulated into granules with a diameter of 0.5 to 1.0 mm to obtain a granule containing 5% of the active ingredient. (Formulation 4: Granules) Five parts of the pesticide composition of the present invention, 73 parts of clay, 20 parts of bentonite, 1 part of dioctyl sulfosuccinate sodium salt, and 1 part of potassium phosphate are thoroughly ground and mixed, water is added, the mixture is thoroughly kneaded, and the mixture is granulated and dried to obtain granules containing 5% of the active ingredient. (Formulation 5: Suspension) 10 parts of the pesticide composition of the present invention, 4 parts of polyoxyethylene alkyl allyl ether, 2 parts of sodium polycarboxylate, 10 parts of glycerin, 0.2 parts of xanthan gum, and 73.8 parts of water are mixed and wet-pulverized until the particle size is 3 microns or less, to obtain a suspension containing 10% of the active ingredient.

[0112] (Formulation 6: Granules) 5 parts of the pesticide composition of the present invention is dissolved in an organic solvent to obtain a solution, and the solution is sprayed onto 94 parts of kaolin and 1 part of white carbon, and then the solvent is evaporated under reduced pressure. This type of granule can be mixed with animal feed. (Formulation 7: Injection) 0.1 to 1 part of the pesticide composition of the present invention and 99 to 99.9 parts of peanut oil are uniformly mixed, and then sterilized by filtration using a sterilizing filter. (Formulation 8: pour-on) Five parts of the pesticide composition of the present invention, 10 parts of myristate ester, and 85 parts of isopropanol are mixed uniformly to obtain a pour-on agent. (Formulation 9: Spot-on) A spot-on agent is obtained by uniformly mixing 10 to 15 parts of the pesticide composition of the present invention, 10 parts of a palmitic acid ester, and 75 to 80 parts of isopropanol. (Formulation 10: Spray) A spray formulation is obtained by uniformly mixing 1 part of the pesticide composition of the present invention, 10 parts of propylene glycol, and 89 parts of isopropanol.

[0113] As described above, the pest control method (1) of the present invention includes applying the pesticide composition of the present invention to a target object. In the control method (1), depending on the dosage form of the pesticide composition, the pesticide composition of the present invention or a formulation containing it may be applied as is, or the pesticide composition of the present invention or a formulation containing it may be diluted with water or the like and then applied. Furthermore, in the control method (1), as described above, the pesticide composition of the present invention or a formulation containing it may be mixed or used in combination with other active ingredients.

[0114] The method for controlling pests (2) of the present invention comprises applying to a target plant the active ingredients of a calcium-activated potassium channel modulator and a stigma-blocking agent or a silicone-based spreading agent simultaneously or in any order.

[0115] The calcium-activated potassium channel modulator used in control method (2) may be formulated. The formulation type is not particularly limited, and examples thereof include dustable powder (DP), wattable powder (WP), emulsifiable concentrate (EC), flowable (FL), suspension concentrate (SC), water-soluble powder (SP), water-dispersible granule (WG), tablet, granule (GR), suspension emulsion (SE), oil dispersion (OD), and emulsion oil in water (EW). The formulation method is not particularly limited, and known methods can be used depending on the formulation type.

[0116] The active ingredient of the stigma-blocking agent or silicone-based spreader used in control method (2) may be formulated. The formulation form is not particularly limited, and examples thereof include dusts (DP, dustable powder), wettable powders (WP, wattable powder), emulsifiable concentrates (EC, emulsifiable concentrates), flowables (FL, flowables), suspension concentrates (SC, suspension concentrates), water-soluble powders (SP, water-soluble powders), water-dispersible granules (WG, water-dispersible granules), tablets, granules (GR, granules), SE (suspension emulsions), OD (oil dispersions), and EW (oil-in-water emulsion) formulations. The formulation method is not particularly limited, and known methods can be used depending on the formulation.

[0117] In control method (2), depending on the dosage form of the calcium-activated potassium channel modulator and the dosage form of the active ingredient of the stigma blocking agent or silicone-based spreader, the calcium-activated potassium channel modulator or a formulation containing it and / or the active ingredient of the stigma blocking agent or silicone-based spreader or a formulation containing it may be applied as is, or the calcium-activated potassium channel modulator or a formulation containing it and / or the active ingredient of the stigma blocking agent or silicone-based spreader or a formulation containing it may be diluted with water, etc. and applied. Furthermore, in control method (2), the calcium-activated potassium channel modulator or a formulation containing it and the active ingredient of the stigma blocking agent or silicone-based spreader or a formulation containing it may be mixed or used in combination with the other active ingredients described above.

[0118] [Biological Testing] The excellent pesticidal properties of the pesticide composition of the present invention will be demonstrated in the following test examples. "%" and "parts" are by weight.

[0119] The following chemical solutions were prepared: Solution A1: Acinonapir wettable powder (active ingredient A: Acinonapir 20.0%, Daniote (registered trademark) Flowable, manufactured by Nippon Soda Co., Ltd.) Solution B1: Fatty acid glyceride emulsion (active ingredient B: 90.0% fatty acid glyceride, Sun Crystal (registered trademark) emulsion, manufactured by Sankei Chemical Co., Ltd.) Solution B2: Blended oil emulsion (active ingredient B: blended oil 97.0% consisting of safflower oil and cottonseed oil, SafOil (registered trademark) emulsion, manufactured by OAT Agrio) Solution B3: Sorbitan fatty acid ester emulsion (active ingredient B: sorbitan fatty acid ester 70.0%, MusiRap (registered trademark) emulsion, manufactured by Maruwa Biochemical Co., Ltd.) Solution B4: Glycerin citrate fatty acid ester emulsion (active ingredient B: glycerin citrate fatty acid ester 50.0%, Pitaichi (registered trademark) emulsion, manufactured by Kyoyu Agri Co., Ltd.) Solution B5: Polyglycerin fatty acid ester emulsion (active ingredient B: polyglycerin fatty acid ester 82.5%, Fumon (registered trademark) emulsion, manufactured by Nippon Kayaku Co., Ltd.) Drug solution B6: Polyoxyethylene methylpolysiloxane (active ingredient B: Polyoxyethylene methylpolysiloxane 93.0%, Makupika (registered trademark), manufactured by Ishihara Biosciences)

[0120] Colby's formula: E(%)=X+YX×Y / 100 X: Actual measured value of effect when treating with component A alone Y: Actual measured value of effect when treating with component B alone E: Expected effect when using ingredient A and ingredient B in combination or in parallel If the actual measured value when components A and B are used in combination or in parallel is greater than the expected value E, a synergistic effect can be inferred from the combined use or parallel use of components A and B.

[0121] Test Example 1 [Efficacy test against two-spotted spider mites (Tetranychus urticae)] Chemical solution A1 and chemical solutions B1 to B4 were mixed appropriately and diluted with water to obtain spray solutions a1 to a10, b1 to b10 and ab1 to ab10 having the active ingredient concentrations shown in Tables 1 and 2, respectively. Ten adult females of the two-spotted spider mite were inoculated onto kidney bean leaves placed in a petri dish. The spray solution was applied to the inoculated kidney bean leaves by 1 cm. 2 Each was sprayed using a rotary spray tower at 2 mg per leaf. The kidney bean leaves were placed in a thermostatic chamber at a temperature of 25°C and a humidity of 65%. Three days after spraying, the number of live and dead adults was counted, and the adult mortality rate was calculated. Ten days after spraying, the number of eggs laid, the number of dead eggs, and the number of surviving offspring were counted, and the egg mortality rate and efficacy were calculated. The adult killing rate, egg killing rate and efficacy are values ​​defined by the following formulas. Kill rate [%] = (number of dead adults / number of test subjects) x 100 Egg killing rate [%] = (number of dead eggs / number of eggs laid) x 100 Effectiveness [%] = 100 - (number of surviving offspring in treated area / number of surviving offspring in untreated area) x 100

[0122] To indicate the degree of synergistic effect, the "expected adult mortality rate," "expected egg mortality rate," and "expected efficacy rate" were calculated based on Colby's formula. The results are shown in Tables 1 and 2.

[0123] [Table 1]

[0124] [Table 2]

[0125] Sprays a1 to a8, which contain acinonapyr alone, did not have a particularly high ovicidal rate. Sprays b1 to b8 also had low adult mortality, ovicidal rates, and efficacy. In contrast, sprays ab1 to ab8 all had ovicidal rates higher than expected, calculated based on Colby's formula. Sprays A9-A10, which used acinonapyr alone at low concentrations of less than 10 ppm, did not have particularly high adult mortality or efficacy. Sprays B9-B10 also had low adult mortality and efficacy. In contrast, sprays AB9-AB10 all had adult mortality or efficacy that was higher than expected based on Colby's formula.

[0126] Test Example 2 [Efficacy test against two-spotted spider mites (Tetranychus urticae)] Chemical solution A1 and chemical solutions B5 to B6 were mixed appropriately and diluted with water to obtain spray solutions a11 to a12, b11 to b12, and ab11 to ab12 having the active ingredient concentrations shown in Table 3, respectively. Ten adult females of the two-spotted spider mite were inoculated onto kidney bean leaves placed in a petri dish. The spray solution was applied to the inoculated kidney bean leaves by 1 cm. 2 The green bean leaves were sprayed at 1.2 mg per leaf using a rotating spray tower. The leaves were placed in a thermostatic chamber at a temperature of 25°C and a humidity of 65%. Ten days after spraying, the number of eggs laid, the number of dead eggs, and the number of surviving offspring were counted, and the egg-killing rate and efficacy were calculated. The ovicidal rate and efficacy are values ​​defined by the following formulas: Egg killing rate [%] = (number of dead eggs / number of eggs laid) x 100 Effectiveness [%] = 100 - (number of surviving offspring in treated area / number of surviving offspring in untreated area) x 100

[0127] To show the degree of synergistic effect, the "expected egg killing rate" and "expected efficacy" were calculated based on Colby's formula. The results are shown in Table 3.

[0128] [Table 3]

[0129] Sprays A11 to A12, which contain only acinonapyr, did not have a particularly high ovicidal rate. Sprays B11 to B12 also had low ovicidal rates and efficacy. In contrast, sprays Ab11 to Ab12 all had ovicidal rates higher than expected, calculated based on Colby's formula.

Claims

1. Acinonapir and and at least one selected from the group consisting of fatty acid glycerides, sorbitan fatty acid esters, glycerin citrate fatty acid esters, polyglycerin fatty acid esters, and polyoxyethylene methylpolysiloxanes; A pest control composition comprising 1 to 100 parts by weight of at least one selected from the group consisting of fatty acid glycerides, sorbitan fatty acid esters, glycerin citrate fatty acid esters, polyglycerin fatty acid esters, and polyoxyethylenemethylpolysiloxanes per part by weight of acinonapyr.

2. A pest control composition as described in claim 1, which when diluted can achieve a concentration of acinonapyr of 1 ppm or more and 1000 ppm or less, and can achieve a concentration of at least one selected from the group consisting of fatty acid glycerides, sorbitan fatty acid esters, glycerin citrate fatty acid esters, polyglycerin fatty acid esters, and polyoxyethylene methylpolysiloxanes of 100 ppm or more and 5000 ppm or less.

3. 3. The pesticide composition according to claim 1, wherein the pest is an insect or a mite harmful to plants.

4. applying acinonapyr and at least one selected from the group consisting of fatty acid glycerides, sorbitan fatty acid esters, glycerin citrate fatty acid esters, polyglycerin fatty acid esters, and polyoxyethylenemethylpolysiloxanes to an object simultaneously or in any order; or The method comprises applying to an object a pest control composition containing acinonapyr and at least one selected from the group consisting of a fatty acid glyceride, a sorbitan fatty acid ester, a glycerin citrate fatty acid ester, a polyglycerin fatty acid ester, and a polyoxyethylene methylpolysiloxane; the amount of at least one selected from the group consisting of fatty acid glycerides, sorbitan fatty acid esters, glycerin citrate fatty acid esters, polyglycerin fatty acid esters, and polyoxyethylenemethylpolysiloxanes is 1 to 100 parts by weight per part by weight of acinonapir; Pest control methods.

5. The concentration of acinonapyr at the time of application is 1 ppm or more and 1000 ppm or less, and the concentration of at least one selected from the group consisting of fatty acid glycerides, sorbitan fatty acid esters, glycerin citrate fatty acid esters, polyglycerin fatty acid esters, and polyoxyethylene methylpolysiloxanes at the time of application is 100 ppm or more and 5000 ppm or less; The method for controlling pests according to claim 4.

6. 6. The method for controlling pests according to claim 4 or 5, wherein the pests are insects or mites harmful to plants.

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