Ultrasonic oral cavity cleaning composition and ultrasonic oral cavity cleaning method

Abstract

This invention enhances a biofilm removing effect when an ultrasonic wave is oscillated in an oral cavity to clean a part to be cleaned. An ultrasonic oral cavity cleaning composition containing water-insoluble particles (A) such as silica particles is brought into contact with a part to be cleaned in the oral cavity, and an ultrasonic wave is applied with the ultrasonic oral cavity cleaning composition serving as a propagation medium.

Description

Ultrasonic oral cleaning composition and ultrasonic oral cleaning method

[0001] The present invention relates to an ultrasonic oral cleaning composition and an ultrasonic oral cleaning method using the ultrasonic oral cleaning composition. This application claims priority based on Japanese Patent Application No. 2023-106640, filed on June 29, 2023, the contents of which are incorporated herein by reference.

[0002] In recent years, the incidence of periodontal disease and its prevalence has increased significantly, making the removal of oral biofilms important. However, biofilms are composed of coaggregates of various oral bacteria and exopolysaccharides, making them difficult to remove. One ultrasonic cleaning method involves ultrasonic cavitation, which uses the shock waves generated by bursting microscopic bubbles in a liquid to clean an object without contact. Ultrasonic cavitation is a phenomenon in which ultrasonic waves are applied to water, causing a sudden pressure change in the gas dissolved in the water, resulting in the generation of shock waves through collapse. For example, Patent Document 1 describes a method of cleaning the oral cavity using a compact, easily inserted ultrasonic oral irrigator, which emits ultrasonic waves while spraying cleaning water, thereby utilizing the cavitation effect.

[0003] Japanese Patent Application Publication No. 2009-136648

[0004] However, conventional cleaning methods do not necessarily provide sufficient cleaning effects. An object of the present invention is to provide an ultrasonic mouthwash composition that can enhance the effect of removing oral biofilms.

[0005] The present invention has the following aspects. [1] An ultrasonic oral cleaning composition comprising water-insoluble particles (A). [2] The ultrasonic oral cleaning composition according to [1], wherein the water-insoluble particles (A) comprise plate-like particles. [3] The ultrasonic oral cleaning composition according to [2], wherein the plate-like particles comprise one or more particles selected from the group consisting of talc, sericite, mica, kaolin, synthetic mica, and synthetic talc. [4] The ultrasonic oral cleaning composition according to [2] or [3], wherein the water-insoluble particles (A) comprise composite particles having a core particle that is the plate-like particle and other particles that cover part or all of the surface of the core particle. [5] The ultrasonic oral cleaning composition according to [4], wherein the other particles comprise one or more particles selected from the group consisting of metal oxide particles, borosilicate particles, and silica particles. [6] The ultrasonic oral cleaning composition according to [5], wherein the metal oxide particles comprise one or more particles selected from the group consisting of titanium oxide particles, iron oxide particles, tin oxide particles, aluminum oxide particles, and chromium oxide particles. [7] The ultrasonic oral cleaning composition according to [1], wherein the water-insoluble particles (A) are titanium oxide-coated mica having a mica core particle and titanium oxide particles coating a part or all of the surface of the core particle. [8] The ultrasonic oral cleaning composition according to [1], wherein the water-insoluble particles (A) are silica particles. [9] The ultrasonic oral cleaning composition according to [1], wherein the water-insoluble particles (A) are calcium-containing inorganic compound particles.

[10] The ultrasonic oral cleaning composition according to [1], wherein the water-insoluble particles (A) are metal oxide particles.

[11] The ultrasonic oral cleaning composition according to [1], wherein the water-insoluble particles (A) have an average particle size of 0.1 to 200 μm.

[12] The ultrasonic oral cleaning composition according to [1], wherein the content of the water-insoluble particles (A) is 0.01 to 1% by mass relative to the total mass of the ultrasonic oral cleaning composition.

[13] The ultrasonic oral cleaning composition according to [1], further comprising a sweetener.

[14] An ultrasonic oral cleaning method, comprising contacting an ultrasonic oral cleaning composition containing water-insoluble particles (A) with an area to be cleaned in the oral cavity and applying ultrasonic waves to the ultrasonic oral cleaning composition.

[0006] According to the present invention, the effect of removing biofilms in the oral cavity can be enhanced.

[0007] The ultrasonic oral cleaning composition of the present invention (hereinafter also referred to simply as the "oral composition") is a composition containing water-insoluble particles (A) (hereinafter also referred to as the "component (A)"). In this specification, a numerical range expressed by "to" means a numerical range with the numbers before and after "to" as the lower and upper limits. The upper and lower limits can be combined arbitrarily. In this specification, the average particle size of component (A) is a value measured by dynamic light scattering (DLS). In this specification, the BET specific surface area of ​​component (A) is a value measured by nitrogen adsorption. In this specification, the pH of the oral composition at 25°C is a value measured by a method in accordance with JIS Z 8802:2011, "pH measurement method."

[0008] <Water-insoluble particles (A)> Component (A) is a water-insoluble particle. Component (A) is preferably a particle made of an inorganic compound. The oral composition may contain one type of component (A), or two or more types of component (A).

[0009] The average particle size of component (A) is preferably 0.1 to 200 μm, more preferably 5 to 180 μm, and even more preferably 10 to 150 μm. When the average particle size of component (A) is at least the lower limit of the above range, a good cleansing effect is likely to be obtained, while when it is at most the upper limit, it is less likely to settle in the oral cavity. When the oral composition contains two or more types of component (A), the above average particle size range refers to the average particle size range for each of the types.

[0010] Examples of component (A) include plate-like particles (A1), composite particles (A2) having a plate-like core particle and other particles covering part or all of the surface of the core particle, silica particles (A3), calcium-containing inorganic compound particles (A4), and metal oxide particles (A5). Silica particles (A3) are particularly preferred in terms of stabilizing various medicinal ingredients that can be used in the oral cavity over time.

[0011] Examples of the plate-like particles (A1) include talc, sericite, mica, kaolin, synthetic mica, and synthetic talc. The average particle size of the plate-like particles (A1) is preferably 1 to 200 μm, more preferably 5 to 180 μm, and even more preferably 10 to 150 μm. For example, known particles to be contained in cosmetics can be used as the plate-like particles (A1). The plate-like particles (A1) are commercially available.

[0012] Examples of core particles constituting the composite particles (A2) include the same plate-like particles as those for the plate-like particles (A1). Examples of other particles constituting the composite particles (A2) include metal oxide particles, borosilicate particles, and silica (silicon dioxide) particles. Examples of the metal oxide particles that are the other particles include titanium oxide particles, iron oxide particles, tin oxide particles, aluminum oxide particles, and chromium oxide particles. An example of borosilicate particles is the cosmetic labeling name "borosilicate (Ca / Al)." The other particles constituting the composite particles (A2) may be of one type or two or more types. Specific examples of the composite particles (A2) include titanium oxide-coated mica (titanium mica), tin oxide, and titanium oxide-coated mica. The average particle size of the composite particles (A2) is preferably 1 to 200 μm, more preferably 5 to 180 μm, and even more preferably 10 to 150 μm. The average particle size range of the composite particles (A2) refers to the average particle size range of the entire composite particle. The composite particles (A2) may be, for example, particles known to be contained in cosmetics. The composite particles (A2) are commercially available.

[0013] The average particle size of the silica particles (A3) is preferably 1 to 200 μm, more preferably 5 to 100 μm, and even more preferably 7.5 to 30 μm. The BET specific surface area of ​​the silica particles (A3) is 20 to 250 m. ２ / g is preferred, and 30 to 200m ２ The oil absorption of the silica particles (A3) is preferably 20 to 300 mL / 100 g, more preferably 30 to 200 mL / 100 g. ２ / g is more preferable, and 50 to 150 mL / 100 g is even more preferable. The oil absorption of silica is determined by the amount of linseed oil absorbed. Specifically, linseed oil is added dropwise to the silica to be measured while kneading with a steel spatula, and the end point is the point at which the whole becomes a single mass with the steel spatula, and the amount of linseed oil absorbed is determined to determine the oil absorption. As the silica particles (A3), for example, particles known to be contained in cosmetics (e.g., abrasive silica, etc.) can be used. Silica particles (A3) are commercially available.

[0014] Examples of calcium-containing inorganic compound particles (A4) include calcium carbonate particles, anhydrous dicalcium phosphate (also known as anhydrous calcium hydrogen phosphate) particles, and anhydrous calcium pyrophosphate particles. The average particle size of the calcium-containing inorganic compound particles (A4) is preferably 1 to 200 μm, more preferably 1 to 50 μm, and even more preferably 5 to 30 μm. For example, known particles to be contained in cosmetics can be used as the calcium-containing inorganic compound particles (A4). Calcium-containing inorganic compound particles (A4) are commercially available.

[0015] Examples of the metal oxide particles (A5) include aluminum oxide particles, titanium oxide particles, and zinc oxide particles. The average particle size of the metal oxide particles (A5) is preferably 0.1 to 200 μm, more preferably 0.1 to 30 μm, and even more preferably 0.1 to 10 μm. As the metal oxide particles (A5), for example, particles known to be contained in cosmetics can be used. The metal oxide particles (A5) are commercially available.

[0016] <Solvent> The oral composition is a liquid that may cause cavitation when ultrasonic waves are applied. For example, a non-viscous liquid can be used. The oral composition contains a solvent in addition to component (A). The solvent preferably contains water. A lower monohydric alcohol, such as ethanol, may be blended as a solvent other than water. The content of component (A) relative to the total mass of the oral composition is preferably 0.01 to 1% by mass, more preferably 0.01 to 0.5% by mass, and even more preferably 0.05 to 0.5% by mass. A content equal to or greater than the lower limit of the above range is likely to provide a good cleansing effect, while a content equal to or less than the upper limit is unlikely to cause cavitation due to the viscosity of the oral composition. The content of the solvent relative to the total mass of the oral composition is preferably 75 to 99.99% by mass, more preferably 80 to 99.99% by mass, and even more preferably 85 to 99.99% by mass. The total content of each component in the oral composition does not exceed 100% by mass. The content of the solvent other than water is preferably 10% by mass or less, more preferably 5% by mass or less, relative to the total mass of the oral composition, and may be substantially zero. In this specification, a content of substantially zero means a content of 0.01% by mass or less relative to the total mass of the oral composition.

[0017] <Other Components> The oral composition may optionally contain other components in addition to component (A) and the solvent, provided that the effects of the present invention are not impaired. Examples of other components that may be added include humectants, thickeners, cationic bactericides, surfactants (S) other than cationic bactericides, pH adjusters, preservatives, flavors, active ingredients, sweeteners, and colorants.

[0018] Examples of humectants include glycerin, sorbitol, propylene glycol, ethylene glycol, polyethylene glycol, xylitol, maltitol, lactite, etc. The content of the humectant relative to the total mass of the oral composition is preferably 0 to 20% by mass, more preferably 0 to 10% by mass.

[0019] Examples of thickeners include xanthan gum, carrageenan, hydroxymethylcellulose, sodium alginate, polyvinyl alcohol, etc. The content of the thickener relative to the total mass of the oral composition is preferably 0 to 0.2% by mass, more preferably 0 to 0.1% by mass.

[0020] Examples of cationic antiseptics include cationic surfactants such as quaternary ammonium salts (e.g., cetylpyridinium chloride, benzalkonium chloride, and benzethonium chloride), and chlorhexidine salts (e.g., chlorhexidine hydrochloride and chlorhexidine gluconate). Among these, the quaternary ammonium salts cetylpyridinium chloride and benzalkonium chloride, particularly cetylpyridinium chloride, are preferred because they provide superior antibacterial properties to oral compositions. One or more cationic antiseptics may be used, or two or more may be used in combination. When a cationic antiseptic is added, the content of the cationic antiseptic is preferably 0.001 to 0.1% by mass, more preferably 0.005 to 0.05% by mass, relative to the total mass of the oral composition. While a higher content of cationic antiseptic improves the antibacterial properties of the oral composition, excessively high content may result in a poor usability.

[0021] Examples of surfactants (S) include nonionic surfactants (S1), anionic surfactants (S2), and amphoteric surfactants (S3). Examples of nonionic surfactants (S1) include polyoxyethylene hydrogenated castor oil having an average number of moles of ethylene oxide added (E.O.) of 40 to 100, and polyoxyethylene alkyl ether having a carbon chain length of 16 to 18 and an average number of moles of ethylene oxide added of 10 to 50. Examples of anionic surfactants (S2) include sodium myristyl sulfate, N-lauroyl sarcosinate, lauroyl methyl taurine, acylamino acid salts, sodium dodecylbenzenesulfonate, α-sulfofatty acid alkyl ester sodium, and alkyl phosphate ester salts. Examples of the amphoteric surfactant (S3) include acetic acid betaine-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine and fatty acid amidopropyldimethylaminoacetic acid betaine; imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salts; and amino acid-type surfactants such as N-fatty acid acyl-L-alginate salts. These surfactants may be used alone or in combination of two or more. The total content of the surfactants (S) relative to the total mass of the oral composition is preferably 0 to 0.1% by mass, more preferably 0 to 0.05% by mass.

[0022] Examples of pH adjusters include phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, carbonic acid, or potassium, sodium, or ammonium salts of these acids; ribonucleic acid or a salt thereof; and sodium hydroxide. One or more pH adjusters may be used. A combination of two or more selected from phosphoric acid, citric acid, sodium salts of phosphoric acid, and sodium salts of citric acid is particularly preferred. The oral composition preferably has a pH of 5.5 to 10.0 at 25°C, and a combination of sodium dihydrogen phosphate and sodium monohydrogen phosphate, or a combination of citric acid and sodium citrate, can be used as a pH adjuster in this range.

[0023] Examples of preservatives include sodium benzoate, alkyldiaminoethylglycine hydrochloride, potassium sorbate, etc. The content of the preservative relative to the total mass of the oral composition is preferably 0 to 1.0% by mass, more preferably 0.1 to 0.5% by mass.

[0024] Examples of fragrances include natural fragrances such as spearmint, eucalyptus, wintergreen, clove, thyme, sage, cardamom, rosemary, marjoram, lemon, nutmeg, lavender, and paraclese; fragrance components contained in the above-mentioned natural essential oils, such as menthol, eugenol, methyl salicylate, l-carvone, 1,8-cineole, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, and spilanthol; Examples of flavoring ingredients include ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methylphenylglycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, maltol, ethyl maltol, gamma / delta decalactone, gamma / delta decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, and ethylene glycol-1-menthyl carbonate; and blended flavors that combine several flavoring ingredients and natural flavors. Examples of blended flavors include apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, and yogurt. These flavoring ingredients may be used alone or in combination. The flavoring ingredient used in the present invention is preferably a water-soluble flavoring (essence). The total content of the flavoring agent is preferably 0.00001 to 3% by mass relative to the total mass of the oral composition.

[0025] Active ingredients that can be added include anti-inflammatory agents such as tranexamic acid and epsilon-aminocaproic acid; enzymes such as dextranase, amylase, protease, mutanase, lysozyme and Liteque enzyme; fluorides such as sodium fluoride, sodium monofluorophosphate and stannous fluoride; vitamins such as aluminum chlorohydroxyallantoin, allantoin, azulene, lysozyme chloride and ascorbic acid; plant extracts such as dihydrocholesterol, glycyrrhetin salts, glycyrrhetinic acids, hydrocholesterol, chlorophyll, copper chlorophyllin sodium, thyme, Scutellaria Root, clove and witch hazel; copper gluconate, callopeptide, sodium polyphosphate, water-soluble inorganic phosphate compounds (inorganic phosphate compounds that dissolve 30 g or more in 1 L of water at 25° C.), polyethylene glycol, polyvinylpyrrolidone, sodium lauroyl sarcosinate, anti-tartar agents, anti-plaque agents, potassium nitrate, aluminum lactate, etc. The amount of these active ingredients to be added can be an effective amount within a range that does not impair the effects of the present invention.

[0026] Examples of sweeteners include saccharin sodium, steviosite, etc. The content of the sweetener relative to the total mass of the oral composition is preferably 0 to 0.5% by mass, more preferably 0.001 to 0.3% by mass.

[0027] As the coloring agent, a highly safe water-soluble pigment such as Blue No. 1, Green No. 3, Yellow No. 4, or Red No. 105 is preferred. The content of the coloring agent relative to the total mass of the oral composition is preferably 0 to 1% by mass, more preferably 0 to 0.5% by mass.

[0028] <Production Method> The oral composition can be produced by mixing component (A), a solvent, and other components as required, and dispersing component (A).

[0029] <Method of Use> The oral composition is used in an ultrasonic oral cleaning method in which ultrasonic waves are generated in the oral cavity to clean the area to be cleaned. Specifically, when the oral composition is brought into contact with the area to be cleaned and ultrasonic waves are applied to the oral composition, the ultrasonic waves propagate through the oral composition. In this process, the ultrasonic waves cause a pressure change in the dissolved gas in the oral composition, which generates shock waves due to collapse (cavitation). These shock waves can peel off, pulverize, and remove biofilms and other materials attached to the area to be cleaned.

[0030] The ultrasonic oral irrigator that emits ultrasonic waves in the oral cavity is not particularly limited. Examples include toothbrush-type ultrasonic oral irrigators that include a head and a handle with a built-in ultrasonic oscillator, and mouthpiece-type ultrasonic oral irrigators that include a built-in ultrasonic oscillator. Toothbrush-type ultrasonic oral irrigators preferably include a reflector in the head that reflects ultrasonic waves and restricts their propagation direction to a specific direction. The oral composition preferably fills the gap between the ultrasonic wave-emitting portion of the ultrasonic oral irrigator and the area to be cleaned. For example, the oral composition is applied to the oral cavity, and the ultrasonic oral irrigator is inserted into the oral cavity to generate ultrasonic waves. The oral composition may be applied to the oral cavity before starting oral cleaning, or a supply means for the oral composition may be inserted into the oral cavity together with the ultrasonic oral irrigator. Examples of the supply means for the oral composition include a tube connected to a reservoir of the oral composition via a pump. The operating frequency during oral cleaning is preferably within a range that efficiently generates cavitation. For example, 20 kHz to 1 MHz is preferred, and 30 kHz to 200 kHz is more preferred.

[0031] The present invention will be described in detail below with reference to examples, but the present invention is not limited to the following description.

[0032] <Measurement Method> (Average Particle Diameter) The average particle diameter of component (A) was measured by dynamic light scattering using a measuring device manufactured by Nikkiso Co., Ltd., product name "Microtrac Particle Size Distribution Meter Model MT3000II," and water as the dispersion medium.

[0033] (pH of Oral Composition) The temperature of the oral composition was adjusted to 25°C, and the pH value was measured using a pH meter (manufactured by Toa Denpa Kogyo Co., Ltd., product name "Hm-30S").

[0034] <Method for evaluating biofilm removal effect> (Bacterial strains used) The following five types of oral bacteria were used: Streptococcus mutans, ATCC25175 strain; Actinomyces viscosus, ATCC43146 strain; Fusobacterium nucleatum, ATCC23146 strain; Veillonella parvula, ATCC17445 strain; and Streptococcus gordonii, ATCC10558 strain.

[0035] (Biofilm formation) The five oral bacterial species were suspended in liquid medium and cultured aerobically at 37°C for 1 day in a 12-well microplate (AGC Technoglass Co., Ltd., product name "IWAKI Tissue Culture Microplate for Adherent Cell Culture 12 Well", well capacity: 6.5 mL) to form a biofilm on the inner wall of the well. Each strain was inoculated into THB (Todd Hewitt Broth) medium (manufactured by Becton Dickinson) containing hemin and menadione and cultured anaerobically (pre-cultured) at 37°C for 24 hours.

[0036] (Ultrasonic Cleaning) After biofilm formation, the sample was washed once with phosphate-buffered saline (PBS) to remove the settled bacteria, yielding an adherent biofilm. After gently adding 3 mL of test solution, an ultrasonic oscillator (a horn connected to an ultrasonic element) was placed 1 cm above the bottom, and ultrasonic waves were applied for 30 seconds at an input voltage of 10 V (approximately 2.5 W). The operating frequency of the ultrasonic waves was 78.4 kHz. To measure the amount of biofilm remaining after ultrasonic cleaning, crystal violet staining was performed and absorbance was measured. Measurements were performed on N samples, and the average absorbance value L was calculated. The absorbance of the biofilm before the addition of the test solution was measured in the same manner as the initial value before cleaning, and the average value L0 of the N samples was calculated. Using the calculated average values ​​L and L0, the biofilm removal rate (unit: %) was calculated according to the following formula (1). Biofilm removal rate = (L0 - L) / L0 × 100 (1)

[0037] Example 1 Titanium oxide-coated mica (manufactured by Merck Performance Materials Merck, product name "Timiron Diamond Cluster MP-149", average particle size 71 μm) was used as component (A). An oral composition was produced by dispersing the titanium oxide-coated mica in pure water. The content of titanium oxide-coated mica relative to the total mass of the oral composition was 0.05 mass%. The pH of the oral composition at 25°C was 5.8. The obtained oral composition was used as a test liquid, and the biofilm removal effect of ultrasonic cleaning was evaluated using the method described above. The number of samples (N) was 12. The results are shown in Table 1.

[0038] Comparative Example 1 The biofilm removal effect by ultrasonic cleaning was evaluated in the same manner as in Example 1, except that pure water (distilled water) was used instead of the oral composition. The results are shown in Table 1.

[0039]

[0040] As shown in the results in Table 1, Example 1, which used an oral composition, had a higher biofilm removal rate and a superior biofilm removal effect than Comparative Example 1, which used pure water.

[0041] Example 2 Silica (manufactured by Taki Chemical Co., Ltd., product name "Silica Anhydrous", average particle size 18.8 μm, oil absorption 95 mL / 100 g) was used as component (A). An oral composition was produced by dispersing silica in pure water. The silica content was 0.1 mass% relative to the total mass of the oral composition. The pH of the oral composition at 25°C was 9.6. The obtained oral composition was used as a test liquid, and the biofilm removal effect by ultrasonic cleaning was evaluated using the method described above. The number of samples (N) was 3. The results are shown in Table 2.

[0042] Comparative Example 2 The biofilm removal effect by ultrasonic cleaning was evaluated in the same manner as in Example 2, except that pure water (distilled water) was used instead of the oral composition. The results are shown in Table 2.

[0043]

[0044] As shown in the results in Table 2, Example 2, which used an oral composition, had a higher biofilm removal rate and a superior biofilm removal effect than Comparative Example 2, which used pure water.

[0045] Examples 3 to 8 The component (A) in Table 3 is as follows. As in Example 2, the component (A) was dispersed in pure water to produce an oral composition, and the biofilm removal rate (N=3) was determined. As in Comparative Example 2, the biofilm removal rate (N=3) was determined using pure water (distilled water) instead of the oral composition. The results are shown in Table 3. In each example, the content of component (A) relative to the total mass of the oral composition and the pH of the oral composition at 25°C are as follows.

[0046] Example 3: Calcium carbonate (manufactured by Mitsuiwahosha, product name "Calcium Carbonate", average particle size 11 μm), content in oral composition 1.0 mass%, oral composition pH 9.0. Example 4: Anhydrous dicalcium phosphate (manufactured by Taihei Chemical Industry Co., Ltd., product name "Dicalcium Phosphate", average particle size 21.2 μm), content in oral composition 0.1 mass%, oral composition pH 7.8. Example 5: Anhydrous calcium pyrophosphate: (manufactured by Taihei Chemical Industry Co., Ltd., product name "Calcium Pyrophosphate", average particle size 7.0 μm), content in oral composition 0.1 mass%, oral composition pH 5.8. Example 6: Aluminum oxide: (manufactured by Nippon Light Metal Co., Ltd., product name "Aluminum Oxide", average particle size 1.4 μm), content in oral composition 0.05 mass%, oral composition pH 9.9. Example 7: Titanium oxide: (manufactured by Ishihara Sangyo Kaisha, Ltd., product name "TIPAQUE CR-50", average particle size 0.3 μm), content in the oral composition 1.0% by mass, oral composition pH 6.2. Example 8: Zinc oxide: (manufactured by PT. INDO LYSIGHT, product name "Zinc Oxide", average particle size 63 μm), content in the oral composition 1.0% by mass, oral composition pH 7.4.

[0047]

[0048] As shown in the results in Table 3, when the oral compositions of Examples 3 to 8 were used, the biofilm removal rate was higher and the biofilm removal effect was improved compared to when pure water was used.

[0049] <Formulation examples of oral compositions> In the following formulation examples, the unit of the amount of each component is "% by mass." The "balance" of water means the amount added so that the total amount (% by mass) of all components contained in the oral composition becomes 100% by mass. The pH value of the oral composition at 25°C is also shown. In all of the following formulation examples, when the oral composition was used as an ultrasonic propagation medium, the biofilm removal rate was higher and the biofilm removal effect was improved compared to when pure water was used.

[0050] Formulation Example 1 (A) Titanium mica 0.05% Citric acid 0.03% Sodium citrate 0.5% Sodium saccharin 0.005% Sodium benzoate 0.5% Water-soluble flavor 0.2% Sodium fluoride 0.044% Water Rest pH: 6.2

[0051] Formulation Example 2 (A) Abrasive silica 0.1% Citric acid 0.03% Sodium citrate 0.5% Sodium saccharin 0.005% Sodium benzoate 0.5% Water-soluble flavor 0.2% Sodium fluoride 0.044% Water Remainder pH: 6.9

[0052] Formulation Example 3 (A) Abrasive silica 1.0% Citric acid 0.03% Sodium citrate 0.5% Sodium saccharin 0.005% Sodium benzoate 0.5% Water-soluble flavor 0.2% Sodium fluoride 0.044% Cetylpyridinium chloride 0.005% Water Remainder pH: 7.2

[0053] Formulation Example 4 (A) Abrasive silica 0.01% Citric acid 0.03% Sodium citrate 0.5% Sodium saccharin 0.005% Sodium benzoate 0.5% Water-soluble flavor 0.2% Sodium fluoride 0.044% Benzethonium chloride 0.001% Water Remainder pH: 6.4

[0054] Formulation Example 5 (A) Aluminum oxide 0.01% Citric acid 0.03% Sodium citrate 0.5% Sodium saccharin 0.005% Sodium benzoate 0.5% Water-soluble flavor 0.2% Sodium fluoride 0.044% Benzethonium chloride 0.01% Water Remainder pH: 6.2

Claims

1. An ultrasonic mouthwash composition comprising water-insoluble particles (A).

2. The ultrasonic mouthwash composition of claim 1, wherein the water-insoluble particles (A) include plate-shaped particles.

3. The ultrasonic mouthwash composition according to claim 2, wherein the plate-like particles comprise one or more selected from the group consisting of talc, sericite, mica, kaolin, synthetic mica and synthetic talc.

4. An ultrasonic oral cleaning composition as described in claim 2 or 3, wherein the water-insoluble particles (A) include composite particles having a core particle which is the plate-like particle and another particle covering part or all of the surface of the core particle.

5. The ultrasonic oral cleaning composition according to claim 4, wherein the other particles include one or more selected from the group consisting of metal oxide particles, borosilicate particles and silica particles.

6. The ultrasonic oral cleaning composition according to claim 5, wherein the metal oxide particles include one or more selected from the group consisting of titanium oxide particles, iron oxide particles, tin oxide particles, aluminum oxide particles and chromium oxide particles.

7. The ultrasonic oral cleaning composition described in claim 1, wherein the water-insoluble particles (A) are titanium oxide-coated mica having a core particle which is mica and titanium oxide particles which cover part or all of the surface of the core particle.

8. The ultrasonic oral cleaning composition according to claim 1, wherein the water-insoluble particles (A) are silica particles.

9. The ultrasonic oral cleaning composition according to claim 1, wherein the water-insoluble particles (A) are calcium-containing inorganic compound particles.

10. The ultrasonic oral cleaning composition according to claim 1, wherein the water-insoluble particles (A) are metal oxide particles.

11. The ultrasonic mouth cleaning composition according to claim 1, wherein the water-insoluble particles (A) have an average particle size of 0.1 to 200 μm.

12. The ultrasonic oral cleaning composition described in claim 1, wherein the content of the water-insoluble particles (A) is 0.01 to 1 mass % relative to the total mass of the ultrasonic oral cleaning composition.

13. The ultrasonic mouthwash composition of claim 1, further comprising a sweetening agent.

14. An ultrasonic oral cleaning method comprising contacting an ultrasonic oral cleaning composition containing water-insoluble particles (A) with an area to be cleaned in the oral cavity and applying ultrasonic waves to the ultrasonic oral cleaning composition.