Optical dual brain signal measurement device

Abstract

The present invention relates to optical fiber photometry. An optical brain signal measurement device (100) according to one embodiment may comprise: a light source unit (110); an excitation filter unit (120); a first segmentation / concatenation unit (130); a second segmentation / concatenation unit (140); an emission filter unit (150); and a measurement unit (160). The optical brain signal measurement device (100) can segment or concatenate optical signals through a segmentation / concatenation unit while transmitting the signals to a brain signal measurement target through an optical fiber having directivity, and identify the wavelength range to which each of multiple signals correspond through a spectrometer to obtain multiple brain signals (multiple light sources) by using the light source directivity of the optical fiber and the spectrometer without a dichroic filter.

Description

Optical Dual Brain Signal Meter

[0001] The present invention relates to an optical brain signal measurement device and method, and to an optical fiber photometric measurement technology that acquires multiple brain signals using the light source directionality and light source classification function of an optical fiber and a spectrometer without an interference filter (dichroic filter).

[0002] Fiber optic photometry technology uses a device that emits light to a target sample using an optical fiber and then receives it back through the optical fiber.

[0003] It is being applied to neural activity research because it can measure optical signals generated deep in the brain of living animals.

[0004] Among the methods for measuring brain signals in a non-invasive manner, there is a technology that extracts and amplifies optical brain response signals using a lock-in amplifier.

[0005] A photodetector is used in the method of extracting and amplifying optical brain response signals using a lock-in amplifier.

[0006] There are technologies that use this, such as a method of measuring brain signals by adding a 405 nm light source to remove auto-fluorescence and noise, and a method of transmitting brain signals from multiple regions (multiple subjects) to a CMOS camera instead of a photodetector using a multimode fiber, and measuring this as a local light source value using software.

[0007] Brain signals are defined as optically calculated values ​​of the intensity of fluorescence recorded by a CMOS camera, and since the calculated values ​​are stored as brain signals rather than the values ​​of the actual measured light source, there is a time gap between the measured values ​​and the calculated values.

[0008] Fiber photometry, which optically records brain signals, including methods for measuring brain signals in a non-invasive manner, requires excitation filters, dichroic filters, and emission filters, as filters are required to set the directionality and wavelength range of light.

[0009] According to the prior art, in order to record multiple regions and multiple objects using multiple optical fibers, an additional interference lens is required, and in order to record multiple brain signals due to the addition of a light source, an additional lens, interference filter, and photodetector are required.

[0010] The purpose of the present invention is to obtain multiple brain signals using the light source directionality and light source classification function of an optical fiber and a spectrometer without an interference filter (dichroic filter).

[0011] The purpose of the present invention is to provide an optical fiber photometric technology for obtaining multiple brain signals by utilizing an optical fiber with a specific directionality and filter function without various lenses and filters.

[0012] The purpose of the present invention is to provide an optical brain signal measurement device and method capable of simultaneous recording of multiple brain signal light sources in an intuitive and monotonous manner without various filter configurations.

[0013] An optical brain signal measuring device according to one embodiment of the present invention comprises: a light source unit for inputting an optical signal of a first wavelength and an optical signal of a second wavelength; an excitation filter unit for transmitting the optical signal of the first wavelength in a first wavelength range and transmitting the optical signal of the second wavelength in a second wavelength range; a first splitting and combining unit for receiving the optical signal transmitted in the first wavelength range and the optical signal transmitted in the second wavelength range based on a first directionality of an optical fiber and outputting a combined signal combining the transmitted optical signals or a divided signal dividing the combined signal; a second splitting and combining unit for transmitting one of the combined signal and the divided signal to at least one brain signal measuring target based on the first directionality of the optical fiber and transmitting a measurement signal returning from the at least one brain signal measuring target based on the second directionality of the optical fiber; an emission filter unit for transmitting the transmitted measurement signal in at least one wavelength range among a third wavelength range and a fourth wavelength range; and for measuring at least one brain signal of the at least one brain signal measuring target based on the measurement signal transmitted in the at least one wavelength range. May include a measuring unit.

[0014] The first directionality of the optical fiber may represent a directionality of transmitting an optical signal from the light source unit to the excitation filter unit, from the excitation filter unit to the first split-coupler unit, from the first split-coupler unit to the second split-coupler unit, and from the second split-coupler unit to the at least one brain signal measurement target, and the second directionality of the optical fiber may represent a directionality of transmitting an optical signal returning from the at least one brain signal measurement target to the second split-coupler unit, from the second split-coupler unit to the emission filter unit, and from the emission filter unit to the measurement unit.

[0015] If the at least one brain signal measurement target is a plurality of brain signal measurement targets, the second splitting and combining unit, the emission filter unit, and the measuring unit may be additionally configured as many times as the number of the plurality of brain signal measurement targets.

[0016] The first split-combining unit can output a combined signal by combining the transmitted optical signals when the at least one brain signal measurement target is one brain signal measurement target, and can output a divided signal by dividing the combined signal when the at least one brain signal measurement target is a plurality of brain signal measurement targets.

[0017] The above first splitting unit can adjust the splitting ratio to any one of 1:10 to 10:1 in relation to the splitting signal.

[0018] The above measurement unit may be a spectrometer when the measurement signal transmitted through the at least one wavelength range is a plurality of wavelength ranges, and may be a photodetector when the measurement signal transmitted through the at least one wavelength range is a single wavelength range.

[0019] An optical brain signal measurement device according to one embodiment of the present invention may include a light source unit that transmits an optical signal of a first wavelength in a first wavelength range and transmits an optical signal of a second wavelength in a second wavelength range in a first directionality, a first splitting and combining unit that combines the optical signal transmitted in the first wavelength range and the optical signal transmitted in the second wavelength range and outputs a combined signal or a split signal obtained by splitting the combined signal through the first optical fiber, a second splitting and combining unit that transmits one of the combined signal and the split signal to at least one brain signal measurement target through the first optical fiber and transmits a measurement signal that returns through a second optical fiber that transmits the measurement signal from the at least one brain signal measurement target in at least one wavelength range among a third wavelength range and a fourth wavelength range and transmits the measurement signal in a second directionality, and a measuring unit that measures at least one brain signal of the at least one brain signal measurement target based on the transmitted measurement signal.

[0020] The first directionality may refer to a directionality in which an optical signal from the light source unit is transmitted to the first split-coupler, transmitted from the first split-coupler to the second split-coupler, and transmitted from the second split-coupler to the at least one brain signal measurement target, and the second directionality may refer to a directionality in which an optical signal returning from the at least one brain signal measurement target is transmitted to the second split-coupler, and transmitted from the second split-coupler to the measurement unit.

[0021] If the at least one brain signal measurement target is a plurality of brain signal measurement targets, the second splitting unit and the measuring unit may be additionally configured as many times as the number of the plurality of brain signal measurement targets.

[0022] The first split-combining unit can output a combined signal by combining the transmitted optical signals when the at least one brain signal measurement target is one brain signal measurement target, and can output a divided signal by dividing the combined signal when the at least one brain signal measurement target is a plurality of brain signal measurement targets.

[0023] The above first splitting unit can adjust the splitting ratio to any one of 1:10 to 10:1 in relation to the splitting signal.

[0024] The above measuring unit may be at least one of a spectrometer and a photodetector.

[0025] An optical brain signal measurement method according to an embodiment of the present invention comprises the steps of: inputting an optical signal of a first wavelength and an optical signal of a second wavelength in a light source unit; transmitting the optical signal of the first wavelength in a first wavelength range and transmitting the optical signal of the second wavelength in a second wavelength range in an excitation filter unit; receiving the optical signal transmitted in the first wavelength range and the optical signal transmitted in the second wavelength range in a first splitting and combining unit based on the first directionality of an optical fiber, and outputting a combined signal obtained by combining the transmitted optical signals or a divided signal obtained by dividing the combined signal; transmitting, in a second splitting and combining unit, one of the combined signal and the divided signal to at least one brain signal measurement target based on the first directionality of the optical fiber, and transmitting a measurement signal returned from the at least one brain signal measurement target based on the second directionality of the optical fiber; transmitting, in an emission filter unit, the transmitted measurement signal in at least one wavelength range among a third wavelength range and a fourth wavelength range; and transmitting, in a measuring unit, a measurement signal transmitted in the at least one wavelength range. It may include a step of measuring at least one brain signal of at least one brain signal measurement target based on the signal.

[0026] The first directionality of the optical fiber may represent a directionality of transmitting an optical signal from the light source unit to the excitation filter unit, from the excitation filter unit to the first split-coupler unit, from the first split-coupler unit to the second split-coupler unit, and from the second split-coupler unit to the at least one brain signal measurement target, and the second directionality of the optical fiber may represent a directionality of transmitting an optical signal returning from the at least one brain signal measurement target to the second split-coupler unit, from the second split-coupler unit to the emission filter unit, and from the emission filter unit to the measurement unit.

[0027] According to one embodiment of the present invention, an optical brain signal measurement method may include a step of transmitting, in a light source unit, an optical signal of a first wavelength in a first wavelength range and an optical signal of a second wavelength in a first directionality through a first optical fiber, a step of combining, in a first splitting and combining unit, an optical signal transmitted in the first wavelength range and an optical signal transmitted in the second wavelength range to output a combined signal or a divided signal obtained by dividing the combined signal through the first optical fiber, a step of transmitting, in a second splitting and combining unit, one of the combined signal and the divided signal through the first optical fiber to at least one brain signal measurement target, and transmitting a measurement signal that returns through a second optical fiber that transmits the measurement signal from the at least one brain signal measurement target in at least one wavelength range among a third wavelength range and a fourth wavelength range and transmits the measurement signal in a second directionality, and a step of measuring, in a measuring unit, at least one brain signal of the at least one brain signal measurement target based on the transmitted measurement signal. there is.

[0028] The first directionality of the optical fiber may represent a directionality of transmitting an optical signal from the light source unit to the excitation filter unit, from the excitation filter unit to the first split-coupler unit, from the first split-coupler unit to the second split-coupler unit, and from the second split-coupler unit to the at least one brain signal measurement target, and the second directionality of the optical fiber may represent a directionality of transmitting an optical signal returning from the at least one brain signal measurement target to the second split-coupler unit, from the second split-coupler unit to the emission filter unit, and from the emission filter unit to the measurement unit.

[0029] The present invention can obtain multiple brain signals by using the light source directionality and light source classification function of an optical fiber and a spectrometer without an interference filter (dichroic filter).

[0030] The present invention can provide an optical fiber photometric technology for acquiring multiple brain signals by utilizing an optical fiber with a specific directionality and filter function without various lenses and filters.

[0031] The present invention can provide an optical brain signal measurement device and method capable of simultaneous recording of multiple brain signal light sources in an intuitive and monotonous manner without various filter configurations.

[0032] FIGS. 1 to 8 are drawings illustrating an optical brain signal measuring device according to one embodiment of the present invention.

[0033] FIG. 9 and FIG. 10 are drawings explaining an optical brain signal measurement method according to one embodiment of the present invention.

[0034] A light source unit that inputs an optical signal of a first wavelength and an optical signal of a second wavelength;

[0035] An excitation filter unit that transmits an optical signal of the first wavelength into a first wavelength range and transmits an optical signal of the second wavelength into a second wavelength range;

[0036] A first splitting and combining unit that receives an optical signal transmitted in the first wavelength range and an optical signal transmitted in the second wavelength range based on the first directionality of the optical fiber, and outputs a combined signal that combines the transmitted optical signals or a split signal that divides the combined signal;

[0037] A second splitting and combining unit that transmits one of the combined signal and the split signal to at least one brain signal measurement target based on the first directionality of the optical fiber, and transmits a measurement signal that returns from the at least one brain signal measurement target based on the second directionality of the optical fiber;

[0038] An emission filter unit that transmits the above-described transmitted measurement signal to at least one of the third wavelength range and the fourth wavelength range; and

[0039] A measuring unit characterized by including at least one brain signal of the at least one brain signal measurement target based on the measurement signal transmitted through the at least one wavelength range.

[0040] Optical brain signal measurement device.

[0041] Specific structural or functional descriptions of embodiments according to the concept of the present invention disclosed in this specification are merely illustrative for the purpose of explaining embodiments according to the concept of the present invention, and embodiments according to the concept of the present invention may be implemented in various forms and are not limited to the embodiments described in this specification.

[0042] Embodiments according to the concept of the present invention may have various modifications and take various forms, and thus, embodiments are illustrated in the drawings and described in detail in this specification. However, this is not intended to limit embodiments according to the concept of the present invention to specific disclosed forms, but rather includes modifications, equivalents, or alternatives that fall within the spirit and technical scope of the present invention.

[0043] While terms such as "first" or "second" may be used to describe various components, these components should not be limited by these terms. These terms are intended solely to distinguish one component from another. For example, a first component may be referred to as a "second component," and similarly, a second component may also be referred to as a "first component," without departing from the scope of the invention.

[0044] When a component is referred to as being "connected" or "connected" to another component, it should be understood that it may be directly connected or connected to that other component, but that there may be other components in between. Conversely, when a component is referred to as being "directly connected" or "directly connected" to another component, it should be understood that there are no other components in between. Expressions that describe relationships between components, such as "between," "immediately between," or "directly adjacent to," should be interpreted similarly.

[0045] The terminology used herein is for the purpose of describing specific embodiments only and is not intended to limit the present invention. The singular expressions include plural expressions unless the context clearly indicates otherwise. In this specification, it should be understood that the terms "comprises" or "has" are intended to specify the presence of a described feature, number, stage, operation, component, part, or combination thereof, but do not preclude the possibility of the presence or addition of one or more other features, numbers, stages, operations, components, parts, or combinations thereof.

[0046] Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. Terms defined in commonly used dictionaries should be interpreted as having a meaning consistent with their meaning in the context of the relevant technology, and will not be interpreted in an idealized or overly formal sense unless explicitly defined herein.

[0047] Hereinafter, embodiments will be described in detail with reference to the attached drawings. However, the scope of the patent application is not limited or restricted by these embodiments. The same reference numerals in each drawing represent the same components.

[0048]

[0049] FIGS. 1 to 8 are drawings illustrating an optical brain signal measuring device according to one embodiment of the present invention.

[0050] FIG. 1 illustrates components of an optical brain signal measurement device that acquires multiple brain signal (multiple light source) signals using the light source directionality of an optical fiber and a spectrometer without an interference filter according to one embodiment of the present invention.

[0051] Referring to FIG. 1, an optical brain signal measurement device (100) according to one embodiment of the present invention may include a light source unit (110), an excitation filter unit (120), a first split-coupler unit (130), a second split-coupler unit (140), an emission filter unit (150), and a measurement unit (160).

[0052] A light source unit (110) according to one embodiment of the present invention inputs an optical signal of a first wavelength and an optical signal of a second wavelength.

[0053] For example, the first wavelength may be a wavelength of 405 nm or 465 nm, and the second wavelength may be a wavelength of 473 nm or 560 nm.

[0054] For example, the light source unit (110) may include a first light source that inputs a light signal of a first wavelength and a second light source that inputs a light signal of a second wavelength.

[0055] According to one embodiment of the present invention, the filter unit (120) transmits an optical signal of a first wavelength into a first wavelength range, and transmits an optical signal of a second wavelength into a second wavelength range.

[0056] The first wavelength range may be 400 nm to 410 nm or 445 nm to 475 nm, and the second wavelength range may be 465 nm to 495 nm or 555 nm to 565 nm.

[0057] For example, the filter unit (120) here may include an excitation filter that transmits an optical signal of a first wavelength to a first wavelength range and an excitation filter that transmits an optical signal of a second wavelength to a second wavelength range.

[0058] According to one embodiment of the present invention, the first splitting and combining unit (130) can receive an optical signal transmitted in a first wavelength range and an optical signal transmitted in a second wavelength range based on the first directionality of the optical fiber, and output a combined signal obtained by combining the transmitted optical signals or a divided signal obtained by dividing the combined signal.

[0059] For example, the first directionality of the optical fiber may represent a directionality in which an optical signal from a light source is transmitted to the excitation filter unit (120), transmitted from the excitation filter unit (120) to the first split-coupling unit (130), transmitted from the first split-coupling unit (130) to the second split-coupling unit (140), and transmitted from the second split-coupling unit (140) to at least one brain signal measurement target.

[0060] According to one embodiment of the present invention, the first split-combining unit (130) can output a combined signal by combining transmitted optical signals when at least one brain signal measurement target is one brain signal measurement target, and can output a divided signal by dividing the combined signal when at least one brain signal measurement target is a plurality of brain signal measurement targets.

[0061] For example, the first splitting unit (130) can adjust the splitting ratio with respect to the split signal to any one of 1:10 to 10:1.

[0062] For example, when there are two lines that output the split signal by splitting the combined signal, the first split-combination unit (130) adjusts the output ratio of the optical signal transmitted to each line to a split ratio of one of 1:10 to 10:1.

[0063] That is, the first split-coupling unit (130) can increase the maximum output signal by adjusting the output ratio of the optical signal to 25:75, 10:90, 50:50, etc.

[0064] The numerical range related to the output ratio of the optical signal is not limited to the above-described range and can be adjusted in various ways within a range that can increase the maximum output signal.

[0065] According to one embodiment of the present invention, the second split-coupling unit (140) can transmit one of the combined signal and the split signal to at least one brain signal measurement target based on the first directionality of the optical fiber, and transmit a measurement signal returning from at least one brain signal measurement target based on the second directionality of the optical fiber.

[0066] For example, the second split-combining unit (140) can output a combined signal by combining the transmitted optical signals in the same manner as the first split-combining unit (130) or output a split signal by dividing the combined signal.

[0067] For example, the second directionality of the optical fiber may represent a directionality in which an optical signal returning from at least one brain signal measurement target is transmitted to the second split-coupling unit (140), transmitted from the second split-coupling unit (140) to the emission filter unit (150), and transmitted from the emission filter unit (150) to the measurement unit (160).

[0068] For example, if at least one brain signal measurement target is a plurality of brain signal measurement targets, the second splitting and combining unit (140), the emission filter unit (150), and the measuring unit (160) may be additionally configured as many times as the number of brain signal measurement targets.

[0069] According to one embodiment of the present invention, the emission filter unit (150) can transmit the transmitted measurement signal to at least one of the third wavelength range and the fourth wavelength range.

[0070] For example, the third wavelength range may be 505 nm to 545 nm, and the fourth wavelength range may be 575 nm to 710 nm.

[0071] According to one embodiment of the present invention, the measuring unit (160) can measure at least one brain signal of at least one brain signal measurement target based on a measurement signal transmitted through at least one wavelength range.

[0072] For example, the measuring unit (160) may use a spectrometer when the measurement signal transmitted through at least one wavelength range is a plurality of wavelength ranges, and may use a photodetector when the measurement signal transmitted through at least one wavelength range is a single wavelength range.

[0073] According to one embodiment of the present invention, an optical brain signal measurement device (100) transmits an optical signal to a brain signal measurement target through a directional optical fiber, divides or combines the signal through a splitting and combining unit, and identifies the wavelength range corresponding to each of the multiple signals through a spectrometer, thereby obtaining multiple brain signal (multiple light source) signals using the light source directionality of the optical fiber and the spectrometer without an interference filter.

[0074] FIG. 2 illustrates a connection circuit of an optical brain signal measurement device that obtains multiple brain signal (multiple light source) signals using the light source directionality of an optical fiber and a spectrometer without an interference filter according to one embodiment of the present invention.

[0075] Referring to FIG. 2, according to one embodiment of the present invention, an optical brain signal measurement device (200) may be composed of a first light source (210), a second light source (211), a first excitation filter (220), a second excitation filter (221), a first split-coupling unit (230), a second split-coupling unit (240), an emission filter (260), and a measurement unit (270).

[0076] The light source input from the first light source (210) and the second light source (211) transmits an optical signal based on the first directionality of the optical fiber connecting each component to the first split coupling unit (230) through the first excitation filter (220) and the second excitation filter (221).

[0077] The first wavelength of the light source input by the first light source (210) may be 405 nm or 465 nm, and the second wavelength of the light source input by the second light source (211) may be 473 nm or 560 nm.

[0078] The first excitation filter (220) transmits a first wavelength range, and the first wavelength range may be 400 nm to 410 nm or 445 nm to 475 nm.

[0079] The second excitation filter (221) transmits a second wavelength range, and the second wavelength range may be 465 nm to 495 nm or 555 nm to 565 nm.

[0080] The first split-coupler (230) transmits the coupling signal to the second split-coupler (240) based on the first directionality.

[0081] The second split coupling unit (240) transmits an optical signal to the brain signal measurement target (250) based on the first directionality, receives a measurement signal returning from the brain signal measurement target (250) based on the second directionality, and transmits the received measurement signal to the emission filter (260).

[0082] The emission filter (260) transmits the transmitted measurement signal to at least one of the third wavelength range and the fourth wavelength range.

[0083] For example, the third wavelength range may be 505 nm to 545 nm, and the fourth wavelength range may be 575 nm to 710 nm.

[0084] The measuring unit (270) may use a spectrometer when the measurement signal transmitted through at least one wavelength range is a plurality of wavelength ranges, and may use a photodetector when the measurement signal transmitted through at least one wavelength range is a single wavelength range.

[0085] The measuring unit (270) detects with a photo detector if the measurement signal is one brain signal in one wavelength range, and detects with a spectrometer if the measurement signal is two or more brain signals in multiple wavelength ranges.

[0086] FIG. 3 illustrates a connection circuit of an optical brain signal measurement device that obtains multiple brain signal (multiple light source) signals using a spectrometer and the light source directionality of an optical fiber without an interference filter in multiple parts of a brain signal measurement target according to one embodiment of the present invention.

[0087] Referring to FIG. 3, according to one embodiment of the present invention, an optical brain signal measuring device (300) may be composed of a first light source (310), a second light source (311), a first excitation filter (320), a second excitation filter (321), a first split coupling unit (330), a second split coupling unit (340), a second split coupling unit (341), an emission filter (360), an emission filter (361), a measuring unit (370), and a measuring unit (371).

[0088] The light source input from the first light source (310) and the second light source (311) transmits an optical signal based on the first directionality of the optical fiber connecting each component to the first split coupling unit (330) through the first excitation filter (320) and the second excitation filter (321).

[0089] The first wavelength of the light source input by the first light source (310) may be 405 nm or 465 nm, and the second wavelength of the light source input by the second light source (311) may be 473 nm or 560 nm.

[0090] The first excitation filter (320) transmits a first wavelength range, and the first wavelength range may be 400 nm to 410 nm or 445 nm to 475 nm.

[0091] The second excitation filter (321) transmits a second wavelength range, and the second wavelength range may be 465 nm to 495 nm or 555 nm to 565 nm.

[0092] The first split-coupler (330) transmits the split signal to the second split-coupler (340) and the second split-coupler (341) based on the first directionality. For example, the split signal may be a signal that is split at the same ratio, and the split ratio may be determined based on a user's settings.

[0093] For example, the first splitting unit (330) can adjust the splitting ratio with respect to the split signal to any one of 1:10 to 10:1.

[0094] For example, when there are two lines that output the split signal by splitting the combined signal, the first split-combination unit (330) adjusts the output ratio of the optical signal transmitted to each line to a split ratio of one of 1:10 to 10:1.

[0095] That is, the first split-coupling unit (330) can increase the maximum output signal by adjusting the output ratio of the optical signal to 25:75, 10:90, 50:50, etc.

[0096] The second split-coupling unit (340) and the second split-coupling unit (341) transmit optical signals to multiple parts of a brain signal measurement target (350) based on a first directionality, receive measurement signals returning from the brain signal measurement target (350) based on a second directionality, and transmit the received measurement signals to the emission filter (360) and the emission filter (361).

[0097] The emission filter (360) and the emission filter (361) transmit the transmitted measurement signal to at least one of the third wavelength range and the fourth wavelength range.

[0098] For example, the third wavelength range may be 505 nm to 545 nm, and the fourth wavelength range may be 575 nm to 710 nm.

[0099] The measuring unit (370) and the measuring unit (371) may use a spectrometer when the measuring signal transmitted through at least one wavelength range is a plurality of wavelength ranges, and may use a photodetector when the measuring signal transmitted through at least one wavelength range is a single wavelength range.

[0100] The measuring unit (370) and the measuring unit (371) can detect with a photo detector if the measurement signal is one brain signal in one wavelength range, and can detect with a spectrometer if the measurement signal is two or more brain signals in multiple wavelength ranges.

[0101] FIG. 4 illustrates a connection circuit of an optical brain signal measurement device that obtains multiple brain signal (multiple light source) signals using the light source directionality of an optical fiber and a spectrometer without an interference filter from a plurality of brain signal measurement targets according to one embodiment of the present invention.

[0102] Referring to FIG. 4, according to one embodiment of the present invention, an optical brain signal measuring device (400) may be composed of a first light source (410), a second light source (411), a first excitation filter (420), a second excitation filter (421), a first split coupling unit (430), a second split coupling unit (440), a second split coupling unit (441), an emission filter (460), an emission filter (461), a measuring unit (470), and a measuring unit (471).

[0103] According to one embodiment of the present invention, the optical brain signal measurement device (400) operates in the same manner as the optical brain signal measurement device (300) described in FIG. 3, and can measure brain signals from a brain signal measurement target (450) and a brain signal measurement target (451).

[0104] FIG. 5 illustrates components of an optical brain signal measurement device that acquires multiple brain signals using an optical fiber having a light source classification function without an interference filter, an excitation filter, or an emission filter according to one embodiment of the present invention.

[0105] Referring to FIG. 5, an optical brain signal measurement device (500) according to an embodiment of the present invention includes a light source unit (510), a first split-coupler unit (520), a second split-coupler unit (530), and a measurement unit (540). The light source unit (510), the first split-coupler unit (520), and the second split-coupler unit (530) may be connected by a first optical fiber (550), and the second split-coupler unit (530) and the measurement unit (540) may be connected by a second optical fiber (551).

[0106] According to one embodiment of the present invention, the light source unit (510) can transmit the light signal of the first wavelength and the light signal of the second wavelength through the first optical fiber (550) that transmits the light signal of the first wavelength in the first wavelength range and transmits the light signal of the second wavelength transmitted in the second wavelength range in the first direction.

[0107] For example, the first splitting unit (520) combines an optical signal transmitted in a first wavelength range and an optical signal transmitted in a second wavelength range and outputs a combined signal or a split signal obtained by splitting the combined signal through the first optical fiber (550).

[0108] For example, the first splitting unit (520) can adjust the splitting ratio with respect to the split signal to any one of 1:10 to 10:1.

[0109] For example, when there are two lines that output the split signal by splitting the combined signal, the first split-combination unit (520) adjusts the output ratio of the optical signal transmitted to each line to a split ratio of one of 1:10 to 10:1.

[0110] That is, the first split-coupling unit (520) can increase the maximum output signal by adjusting the output ratio of the optical signal to 25:75, 10:90, 50:50, etc.

[0111] The numerical range related to the output ratio of the optical signal is not limited to the above-described range and can be adjusted in various ways within a range that can increase the maximum output signal.

[0112] According to one embodiment of the present invention, the second split-coupling unit (530) transmits one of the combined signal and the split signal to at least one brain signal measurement target through the first optical fiber (550).

[0113] For example, the second split-combining unit (140) can output a combined signal by combining the transmitted optical signals in the same manner as the first split-combining unit (130) or output a split signal by dividing the combined signal.

[0114] In addition, the second split-coupling unit (530) can transmit a measurement signal that returns through a second optical fiber (551) that transmits the measurement signal from at least one brain signal measurement target in at least one wavelength range of the third wavelength range and the fourth wavelength range in the second direction.

[0115] According to one embodiment of the present invention, the measuring unit (540) can measure at least one brain signal of at least one brain signal measurement target based on the transmitted measurement signal.

[0116] According to one embodiment of the present invention, the first optical fiber (550) classifies and transmits the wavelength of the light source so that the wavelength range of the combined signal combined in the first splitting and combining unit (520) is 473 nm to 561 nm when the wavelength input from the first light source is 465 nm and the wavelength input from the second light source is 560 nm.

[0117] According to one embodiment of the present invention, the second optical fiber (551) classifies and transmits the wavelength of the light source so that the wavelength range of the measurement signal transmitted to the measurement unit (540) is 532 nm to 670 nm.

[0118] According to one embodiment of the present invention, an optical brain signal measurement device (500) transmits an optical signal to a brain signal measurement target through an optical fiber having directionality and wavelength transmission (classification) functions, divides or combines the signal through a splitting and combining unit, and identifies the wavelength range corresponding to each of the multiple signals through a spectrometer, thereby obtaining multiple brain signal (multiple light source) signals without an interference filter, an excitation filter, and an emission filter.

[0119] FIG. 6 illustrates a connection circuit of an optical brain signal measurement device that acquires multiple brain signals using an optical fiber having a light source classification function without an interference filter, an excitation filter, or an emission filter according to one embodiment of the present invention.

[0120] Referring to FIG. 6, according to one embodiment of the present invention, an optical brain signal measurement device (600) may be composed of a first light source (610), a second light source (611), a first split coupling unit (630), a second split coupling unit (640), and a measurement unit (670).

[0121] The first light source (610) transmits an optical signal (620) of a wavelength range through the first optical fiber and the second light source (611) transmits an optical signal (621) of a wavelength range through the first optical fiber to the first split-coupler (630), and the optical signal (620) and optical signal (621) combined in the first split-coupler (630) are transmitted to the second split-coupler (640).

[0122] The second split-coupling unit (640) transmits an optical signal (620) and an optical signal (621) to a brain signal measurement target (650), and transmits an optical signal (660) and an optical signal (661) whose wavelength range has been transmitted through the second optical fiber to the measurement unit (670).

[0123] According to one embodiment of the present invention, an optical brain signal measurement device (600) is an optical fiber photometric measurement technology without interference filters and excitation and emission filters, using a multi-functional optical fiber that transmits only light sources of a specific wavelength and a directionality of a light source, and can record multiple brain signal light sources.

[0124] According to one embodiment of the present invention, the first optical fiber related to the optical signal (620) and the optical signal (621) classifies and transmits the wavelength of the light source so that the wavelength range of the combined signal combined in the first splitting and combining unit (630) is 473 nm to 561 nm when the wavelength input from the first light source is 465 nm and the wavelength input from the second light source is 560 nm.

[0125] According to one embodiment of the present invention, the second optical fiber associated with the optical signal (660) and the optical signal (661) classifies and transmits the wavelength of the light source so that the wavelength range of the measurement signal transmitted to the measurement unit (670) is 532 nm to 670 nm.

[0126] FIG. 7 illustrates a connection circuit of an optical brain signal measurement device that acquires multiple brain signals using an optical fiber having a light source classification function without an interference filter, an excitation filter, or an emission filter for multiple parts of a brain signal measurement target according to one embodiment of the present invention.

[0127] Referring to FIG. 7, according to one embodiment of the present invention, an optical brain signal measurement device (700) may be composed of a first light source (710), a second light source (711), a first split coupling unit (730), a second split coupling unit (740), a second split coupling unit (741), and a measuring unit (770) and a measuring unit (771).

[0128] The first light source (710) transmits an optical signal (720) of a wavelength range through the first optical fiber and the second light source (711) transmits an optical signal (721) of a wavelength range through the first optical fiber to the first split-coupling unit (730), and the optical signal (720) and optical signal (721) split in the first split-coupling unit (730) are transmitted to the second split-coupling unit (740) and the second split-coupling unit (741).

[0129] For example, the first splitting unit (730) can adjust the splitting ratio with respect to the split signal to any one of 1:10 to 10:1.

[0130] For example, when there are two lines that output the split signal by splitting the combined signal, the first split-combination unit (730) adjusts the output ratio of the optical signal transmitted to each line to a split ratio of one of 1:10 to 10:1.

[0131] That is, the first split-coupling unit (730) can increase the maximum output signal by adjusting the output ratio of the optical signal to 25:75, 10:90, 50:50, etc.

[0132] The numerical range related to the output ratio of the optical signal is not limited to the above-described range and can be adjusted in various ways within a range that can increase the maximum output signal.

[0133] The second split-coupling unit (740) transmits an optical signal (720) and an optical signal (721) to a brain signal measurement target (750), and transmits an optical signal (760) and an optical signal (761) whose wavelength range has been transmitted through the second optical fiber to a measuring unit (770) and a measuring unit (771).

[0134] For example, the second split-combiner (740) can output a combined signal by combining the transmitted optical signals in the same manner as the first split-combiner (730) or output a split signal by dividing the combined signal.

[0135] FIG. 8 illustrates a connection circuit of an optical brain signal measurement device that acquires multiple brain signals using an optical fiber having a light source classification function without an interference filter, an excitation filter, or an emission filter for a plurality of brain signal measurement targets according to one embodiment of the present invention.

[0136] Referring to FIG. 8, according to one embodiment of the present invention, an optical brain signal measurement device (800) may be composed of a first light source (810), a second light source (811), a first split coupling unit (830), a second split coupling unit (840), a second split coupling unit (841), and a measuring unit (870) and a measuring unit (871).

[0137] The first light source (810) transmits an optical signal (820) of a wavelength range through the first optical fiber and the second light source (811) transmits an optical signal (821) of a wavelength range through the first optical fiber to the first split-coupling unit (830), and the optical signal (820) and optical signal (821) split in the first split-coupling unit (830) are transmitted to the second split-coupling unit (840) and the second split-coupling unit (841).

[0138] The second split coupling unit (840) transmits optical signals (820) and (821) to the brain signal measurement target (850) and the brain signal measurement target (851), and transmits optical signals (860) and (861) whose wavelength range has been transmitted through the second optical fiber to the measurement unit (870) and the measurement unit (871).

[0139] According to one embodiment of the present invention, a brain signal measuring device can measure brain signals by measuring the optical fiber luminosity of multiple brain signal recordings using an optical fiber having a light source classification function without an interference filter, an excitation filter, or an emission filter.

[0140] Accordingly, the present invention can provide an optical brain signal measurement device and method capable of simultaneous recording of multiple brain signal light sources in an intuitive and monotonous manner without various filter configurations.

[0141]

[0142] FIG. 9 and FIG. 10 are drawings explaining an optical brain signal measurement method according to one embodiment of the present invention.

[0143] FIG. 9 illustrates an optical brain signal measurement method for obtaining multiple brain signal (multiple light source) signals using the light source directionality of an optical fiber and a spectrometer without an interference filter according to one embodiment of the present invention.

[0144] Referring to FIG. 9, in step (901), an optical brain signal measurement method according to one embodiment of the present invention inputs an optical signal.

[0145] That is, in one embodiment of the present invention, the optical brain signal measurement method can input an optical signal of a first wavelength and an optical signal of a second wavelength.

[0146] In step (902), in one embodiment of the present invention, the optical brain signal measurement method transmits in a specific wavelength range.

[0147] That is, in one embodiment of the present invention, the optical brain signal measurement method can transmit an optical signal of a first wavelength into a first wavelength range and transmit an optical signal of a second wavelength into a second wavelength range.

[0148] In step (903), the optical brain signal measurement method of one embodiment of the present invention outputs a combined signal or a split signal.

[0149] That is, in one embodiment of the present invention, the optical brain signal measurement method can receive an optical signal transmitted in a first wavelength range and an optical signal transmitted in a second wavelength range based on the first directionality of the optical fiber, and output a combined signal by combining the transmitted optical signals or a divided signal by dividing the combined signal.

[0150] In step (904), an optical brain signal measurement method according to one embodiment of the present invention receives and transmits a measurement signal from a brain signal measurement target.

[0151] That is, in one embodiment of the present invention, an optical brain signal measurement method can transmit one of a combined signal and a split signal to at least one brain signal measurement target based on a first directionality of an optical fiber, and transmit a measurement signal returning from at least one brain signal measurement target based on a second directionality of the optical fiber.

[0152] In step (905), in one embodiment of the present invention, the optical brain signal measurement method transmits in a specific wavelength range.

[0153] That is, in one embodiment of the present invention, the optical brain signal measurement method can transmit the transmitted measurement signal into at least one wavelength range among the third wavelength range and the fourth wavelength range.

[0154] In step (906), an optical brain signal measurement method according to one embodiment of the present invention measures a brain signal.

[0155] That is, in one embodiment of the present invention, the optical brain signal measurement method can measure at least one brain signal of at least one brain signal measurement target based on a measurement signal transmitted through at least one wavelength range.

[0156] FIG. 10 illustrates an optical brain signal measurement method for obtaining multiple brain signals using an optical fiber having a light source classification function without an interference filter, an excitation filter, or an emission filter according to one embodiment of the present invention.

[0157] Referring to FIG. 10, in step (1001), an optical brain signal measurement method according to one embodiment of the present invention inputs an optical signal.

[0158] That is, in one embodiment of the present invention, the optical brain signal measurement method can transmit the optical signal of the first wavelength and the optical signal of the second wavelength through a first optical fiber that transmits the optical signal of the first wavelength in a first wavelength range and transmits the optical signal of the second wavelength transmitted in the second wavelength range in a first direction.

[0159] In step (1002), an optical brain signal measurement method according to one embodiment of the present invention outputs a combined signal or a split signal.

[0160] That is, in one embodiment of the present invention, the optical brain signal measurement method can combine an optical signal transmitted in a first wavelength range and an optical signal transmitted in a second wavelength range and output a combined signal or a split signal obtained by splitting the combined signal through a first optical fiber.

[0161] In step (1003), an optical brain signal measurement method according to one embodiment of the present invention receives and transmits a measurement signal from a brain signal measurement target.

[0162] That is, in one embodiment of the present invention, the optical brain signal measurement method can transmit one of the combined signal and the split signal to at least one brain signal measurement target through a first optical fiber, and transmit the measurement signal returning from the at least one brain signal measurement target through a second optical fiber that transmits the measurement signal in a second direction by transmitting it in at least one wavelength range among a third wavelength range and a fourth wavelength range.

[0163] In step (1004), an optical brain signal measurement method according to one embodiment of the present invention measures a brain signal.

[0164] That is, in one embodiment of the present invention, the optical brain signal measurement method can measure at least one brain signal of at least one brain signal measurement target based on a measurement signal transmitted through at least one wavelength range.

[0165] Accordingly, the present invention can provide an optical brain signal measurement device and method capable of simultaneous recording of multiple brain signal light sources in an intuitive and monotonous manner without various filter configurations.

[0166]

[0167] The devices described above may be implemented as hardware components, software components, and / or a combination of hardware components and software components. For example, the devices and components described in the embodiments may be implemented using one or more general-purpose computers or special-purpose computers, such as, for example, a processor, a controller, an arithmetic logic unit (ALU), a digital signal processor, a microcomputer, a field programmable array (FPA), a programmable logic unit (PLU), a microprocessor, or any other device capable of executing instructions and responding to them. The processing device may execute an operating system (OS) and one or more software applications running on the operating system. The processing device may also access, store, manipulate, process, and generate data in response to the execution of the software. For ease of understanding, the processing device is sometimes described as being used alone; however, one of ordinary skill in the art will recognize that the processing device may include multiple processing elements and / or multiple types of processing elements. For example, a processing unit may include multiple processors, or a processor and a controller. Other processing configurations, such as parallel processors, are also possible.

[0168] The method according to the embodiment may be implemented in the form of program commands that can be executed through various computer means and recorded on a computer-readable medium. The computer-readable medium may include program commands, data files, data structures, etc., alone or in combination. The program commands recorded on the medium may be those specially designed and configured for the embodiment or may be those known and available to those skilled in the art of computer software. Examples of the computer-readable recording medium include magnetic media such as hard disks, floppy disks, and magnetic tapes, optical media such as CD-ROMs and DVDs, magneto-optical media such as floptical disks, and hardware devices specially configured to store and execute program commands, such as ROMs, RAMs, and flash memories. Examples of the program commands include not only machine language codes generated by a compiler, but also high-level language codes that can be executed by a computer using an interpreter, etc. The hardware devices described above may be configured to operate as one or more software modules to perform the operations of the embodiment, and vice versa.

[0169] Software may include a computer program, code, instructions, or a combination of one or more of these, which may configure a processing device to perform a desired operation or may, independently or collectively, command the processing device. The software and / or data may be permanently or temporarily embodied in any type of machine, component, physical device, virtual equipment, computer storage medium or device, or transmitted signal wave, for interpretation by the processing device or for providing instructions or data to the processing device. The software may also be distributed over networked computer systems and stored or executed in a distributed manner. The software and data may be stored on one or more computer-readable recording media.

[0170] Although the embodiments described above have been described with limited drawings, those skilled in the art will recognize that various modifications and variations can be made based on the above description. For example, appropriate results can still be achieved even if the described techniques are performed in a different order than described, and / or components of the described systems, structures, devices, circuits, etc. are combined or combined in a different manner than described, or are replaced or substituted with other components or equivalents.

[0171] Therefore, other implementations, other embodiments, and equivalents to the claims also fall within the scope of the claims described below.

[0172] The present invention relates to an optical brain signal measurement device and method, and to an optical fiber photometric measurement technology that acquires multiple brain signals using the light source directionality and light source classification function of an optical fiber and a spectrometer without an interference filter (dichroic filter).

Claims

1. A light source unit that inputs a light signal of a first wavelength and a light signal of a second wavelength; An excitation filter unit that transmits an optical signal of the first wavelength into a first wavelength range and transmits an optical signal of the second wavelength into a second wavelength range; A first splitting and combining unit that receives an optical signal transmitted in the first wavelength range and an optical signal transmitted in the second wavelength range based on the first directionality of the optical fiber, and outputs a combined signal that combines the transmitted optical signals or a split signal that divides the combined signal; A second splitting and combining unit that transmits one of the combined signal and the split signal to at least one brain signal measurement target based on the first directionality of the optical fiber, and transmits a measurement signal that returns from the at least one brain signal measurement target based on the second directionality of the optical fiber; An emission filter unit that transmits the above-described transmitted measurement signal to at least one of the third wavelength range and the fourth wavelength range; and A measuring unit characterized by including at least one brain signal of the at least one brain signal measurement target based on the measurement signal transmitted through the at least one wavelength range. Optical brain signal measurement device.

2. In paragraph 1, The first directionality of the optical fiber represents a directionality of transmitting an optical signal from the light source unit to the excitation filter unit, transmitting it from the excitation filter unit to the first split-coupler unit, transmitting it from the first split-coupler unit to the second split-coupler unit, and transmitting it from the second split-coupler unit to the at least one brain signal measurement target. The second directionality of the optical fiber is characterized in that it transmits the optical signal returning from the at least one brain signal measurement target to the second splitting and combining unit, transmits it from the second splitting and combining unit to the emission filter unit, and transmits it from the emission filter unit to the measurement unit. Optical brain signal measurement device.

3. In paragraph 1, In the case where the at least one brain signal measurement target is a plurality of brain signal measurement targets, the second splitting and combining unit, the emission filter unit, and the measuring unit are additionally configured as many times as the number of the plurality of brain signal measurement targets. Optical brain signal measurement device.

4. In paragraph 1, The first split-combining unit is characterized in that, when the at least one brain signal measurement target is one brain signal measurement target, it outputs a combined signal by combining the transmitted optical signals, and when the at least one brain signal measurement target is a plurality of brain signal measurement targets, it outputs a divided signal by dividing the combined signal. Optical brain signal measurement device.

5. In paragraph 4, The above first splitting unit is characterized in that it adjusts the splitting ratio to any one of 1:10 to 10:1 in relation to the splitting signal. Optical brain signal measurement device.

6. In paragraph 1, The above measurement unit is characterized in that, if the measurement signal transmitted through the at least one wavelength range is a plurality of wavelength ranges, it is a spectrometer, and if the measurement signal transmitted through the at least one wavelength range is a single wavelength range, it is a photodetector. Optical brain signal measurement device.

7. A light source unit that transmits an optical signal of a first wavelength and an optical signal of a second wavelength through a first optical fiber that transmits an optical signal of a first wavelength in a first wavelength range and transmits an optical signal of a second wavelength in a second wavelength range in a first direction; A first splitting and combining unit that combines an optical signal transmitted in the first wavelength range and an optical signal transmitted in the second wavelength range and outputs a combined signal or a split signal obtained by splitting the combined signal through the first optical fiber; A second split-coupler that transmits one of the combined signal and the split signal to at least one brain signal measurement target through the first optical fiber, and transmits a measurement signal that returns from the at least one brain signal measurement target through a second optical fiber that transmits the measurement signal in a second direction by transmitting the measurement signal in at least one of the third wavelength range and the fourth wavelength range; and It is characterized by including a measuring unit that measures at least one brain signal of the at least one brain signal measurement target based on the transmitted measurement signal. Optical brain signal measurement device.

8. In paragraph 7, The first directionality refers to a directionality in which an optical signal from the light source is transmitted to the first split-coupler, transmitted from the first split-coupler to the second split-coupler, and transmitted from the second split-coupler to the at least one brain signal measurement target. The second directionality is characterized in that it represents a directionality in which an optical signal returning from the at least one brain signal measurement target is transmitted to the second split-coupling unit and transmitted from the second split-coupling unit to the measurement unit. Optical brain signal measurement device.

9. In paragraph 7, In the case where the at least one brain signal measurement target is a plurality of brain signal measurement targets, the second splitting and combining unit and the measuring unit are additionally configured as many as the number of the plurality of brain signal measurement targets. Optical brain signal measurement device.

10. In paragraph 7, The first split-combining unit is characterized in that, when the at least one brain signal measurement target is one brain signal measurement target, it outputs a combined signal by combining the transmitted optical signals, and when the at least one brain signal measurement target is a plurality of brain signal measurement targets, it outputs a divided signal by dividing the combined signal. Optical brain signal measurement device.

11. In paragraph 10, The above first splitting unit is characterized in that it adjusts the splitting ratio to any one of 1:10 to 10:1 in relation to the splitting signal. Optical brain signal measurement device.

12. In paragraph 7, The above measuring unit is characterized by being at least one of a spectrometer and a photodetector. Optical brain signal measurement device.

13. A step of inputting a light signal of a first wavelength and a light signal of a second wavelength in a light source unit; Here, in the filter section, a step of transmitting the optical signal of the first wavelength into a first wavelength range and transmitting the optical signal of the second wavelength into a second wavelength range; A step of receiving, in a first splitting and combining unit, an optical signal transmitted in the first wavelength range and an optical signal transmitted in the second wavelength range based on the first directionality of the optical fiber, and outputting a combined signal obtained by combining the transmitted optical signals or a divided signal obtained by dividing the combined signal; In a second split-coupling unit, a step of transmitting one of the combined signal and the split signal to at least one brain signal measurement target based on the first directionality of the optical fiber, and transmitting a measurement signal returning from the at least one brain signal measurement target based on the second directionality of the optical fiber; In the emission filter section, a step of transmitting the transmitted measurement signal to at least one of the third wavelength range and the fourth wavelength range; and In the measuring unit, it is characterized by including a step of measuring at least one brain signal of the at least one brain signal measurement target based on the measurement signal transmitted through the at least one wavelength range. Optical brain signal measurement method.

14. In paragraph 12, The first directionality of the optical fiber represents a directionality of transmitting an optical signal from the light source unit to the excitation filter unit, transmitting it from the excitation filter unit to the first split-coupler unit, transmitting it from the first split-coupler unit to the second split-coupler unit, and transmitting it from the second split-coupler unit to the at least one brain signal measurement target. The second directionality of the optical fiber is characterized in that it transmits the optical signal returning from the at least one brain signal measurement target to the second splitting and combining unit, transmits it from the second splitting and combining unit to the emission filter unit, and transmits it from the emission filter unit to the measurement unit. Optical brain signal measurement method.

15. A step of transmitting an optical signal of a first wavelength and an optical signal of a second wavelength through a first optical fiber that transmits an optical signal of a first wavelength in a first wavelength range and transmits an optical signal of a second wavelength transmitted in a second wavelength range in a first direction in a light source unit; In a first splitting and combining unit, a step of combining an optical signal transmitted in the first wavelength range and an optical signal transmitted in the second wavelength range and outputting a combined signal or a split signal obtained by splitting the combined signal through the first optical fiber; In a second split-coupling unit, a step of transmitting one of the combined signal and the split signal to at least one brain signal measurement target through the first optical fiber, and transmitting a measurement signal returning from the at least one brain signal measurement target through a second optical fiber that transmits the measurement signal in at least one wavelength range among the third wavelength range and the fourth wavelength range in a second direction; and In the measuring unit, it is characterized by including a step of measuring at least one brain signal of the at least one brain signal measurement target based on the transmitted measurement signal. Optical brain signal measurement method.

16. In paragraph 15, The first directionality refers to a directionality in which an optical signal from the light source is transmitted to the first split-coupler, transmitted from the first split-coupler to the second split-coupler, and transmitted from the second split-coupler to the at least one brain signal measurement target. The second directionality is characterized in that it represents a directionality in which an optical signal returning from the at least one brain signal measurement target is transmitted to the second split-coupling unit and transmitted from the second split-coupling unit to the measurement unit. Optical brain signal measurement method.

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