Preparation process and system for aerosol gas-producing agent

Abstract

A preparation process and system for an aerosol gas-producing agent, the system mainly comprising a raw material preparation system, a material mixing system, a granulation system, a drying system, a screening system, a cartridge loading system, a filling and compressing system, a tableting system, a conveying system, etc. The production line proposed in the present invention can achieve automated production for the processes of raw material crushing, adhesive preparation, feeding, mixing, granulation, drying, screening, weighing and cartridge loading, palletization, tableting, compressing, and logistics transportation. Except for raw material palletization, conveyance of raw materials to designated locations, pallet replacement, cartridge replacement, and chemical agent packing, which are manually performed, all other process operations on the production line are carried out by driving cylinders or explosion-proof motors, and the operations are simple, practical, and reliable.

Description

Aerosol gas-generating agent preparation process and system Technical Field

[0001] The present invention belongs to the technical field of aerosol gas generating medicine preparation, and in particular relates to an aerosol gas generating medicine preparation process and system. Background Art

[0002] Aerosol gas-generating agent is a fire extinguishing agent developed by our company. Currently, there is no fully automated production line. The production process generally includes raw material preparation, raw material mixing, agent granulation, agent drying, agent column pressing, and agent slicing. Each process is a separate workshop, without full online production or automated production. As a result, production efficiency is low and cannot adapt to order demand. After searching, it was found that the technologies disclosed in this field are all preparation processes or equipment for individual processes, without achieving fully automated production, and the degree of automation is not high.

[0003] Summary of the Invention

[0004] In view of the technical problems existing in the background technology, the aerosol gas-generating medicine preparation process and system provided by the present invention can realize the automated production of raw material crushing, adhesive preparation, feeding, mixing, granulation, drying, screening, weighing and barreling, coding and tableting, medicine pressing and logistics transmission. Except for the coding of raw materials and delivering raw materials to designated locations, changing pallets, changing tablets and medicine barrels, and medicine column packing, which are completed manually, the other process actions of the production line are driven by cylinders or explosion-proof motors, and the actions are simple, practical and reliable.

[0005] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0006] A process for preparing an aerosol gas-generating agent comprises the following steps:

[0007] Step 1, raw material preparation: the raw materials include resin, methanol, oxidant and reducing agent;

[0008] The resin is placed in a resin temporary storage weighing device, the methanol is placed in a methanol high-level tank, the oxidant is placed in an oxidant temporary storage weighing device, and the reducing agent is placed in a reducing agent temporary storage weighing device;

[0009] Step 2: Mix the raw materials:

[0010] 1) Mixing resin and methanol to prepare adhesive,

[0011] 2) crushing the oxidant;

[0012] 3) After weighing the oxidant and the reducing agent, dry mix the oxidant and the reducing agent;

[0013] The oxidant is crushed and stored in an oxidant temporary storage and weighing device; the oxidant is potassium nitrate or strontium nitrate, and the reducing agent is melamine or dicyandiamide;

[0014] Step 3, adding a binder to the mixture of the oxidizing agent and the reducing agent and wet mixing them to prepare a wet agent;

[0015] Step 4: Add the wet agent into the granulator for granulation.

[0016] Step 5: The granulated medicine falls onto the lifting conveyor belt after passing through the collection bucket and is transported to the horizontal vibrating fluidized bed by the lifting conveyor belt to start drying;

[0017] Step 6: Cool the dried medicine, and then convey the cooled medicine to the crushing device via the cooling belt. The crushed medicine falls into the screening device for screening. The screened medicine falls onto the barreling belt and is conveyed backward.

[0018] Step 7: The qualified medicines are weighed at the medicine filling station and then packed into barrels;

[0019] Specifically, the medicine barrel is placed on the empty pallet of the conveyor line by a truss robot, and the barrel cover is removed by the lid pick-up and placement device. The medicine barrel is then conveyed to the bottom of the swing granulator discharge port. The weighing device's lifting cylinder drives the weighing sensor and the medicine barrel to rise together to prepare the barrel loading equipment. The barrel is weighed while being loaded. When the weight of the medicine in the barrel reaches the set value, the feeding is stopped, and the conveyor line repositioning device will change the line with the full barrel, and then the next empty barrel can be loaded.

[0020] Step 8: transport the loaded medicine barrels to the medicine pressing room, which is used to compress the loose medicine into medicine columns. The empty barrels are transported back to the medicine filling station in step 7.

[0021] Step 9, delivering the drug column to a tableting machine for tableting;

[0022] Step 10: Pack the tablets and the preparation process is completed.

[0023] The medicine barrels are transported to the compression room and poured into the hopper. The dosing machine automatically weighs the medicine and adds it to the mold. The turntable assembly transfers the molds between stations. The press presses the medicine into pellets, which are then transported out of the room by the finished product conveyor. The tableting machine was modified to include a barrel conveyor and a finished product conveyor, enabling automated loading and the delivery of finished tablets to the barrels.

[0024] Preferably, in step 2, the adhesive preparation needs to be carried out before dry mixing, and the sub-steps are as follows:

[0025] Step 2.1: When preparing the adhesive, manually stack the resin raw material bags on the pallet, then use a forklift to place the pallet on the designated area pallet storage rack according to the type of raw material, ready for the robot to load the material;

[0026] Step 2.2: The methanol required for preparing the adhesive is extracted into the methanol high-level tank by a vacuum pump under negative pressure. When the high-level tank is full, a certain amount of methanol is added to the adhesive preparation tank. A total of two extractions of methanol are required. Methanol measurement is achieved using a flow meter.

[0027] In step 2.3, the feeding robot picks up one bag of resin at a time and opens it above the feed port of the resin temporary storage and weighing device (a bag-opening blade is installed above the feeding hopper). The vibrating feeding mechanism adds the material to the weighing hopper and weighs it simultaneously. When the weight reaches the set value, feeding stops. Then, the vacuum feeder starts to add the resin raw material in the weighing hopper to the corresponding adhesive preparation tank. At this time, the stirring paddle of the adhesive preparation tank starts, and hot water is added to the preparation tank interlayer to circulate for temperature control. The two adhesive preparation tanks share a single vacuum feeder, and a reversing valve is used to switch between the two feeding modes.

[0028] Step 2.4: Manually stack the bags of oxidant and reductant raw materials required for production on pallets. Then, manually use a forklift to place the pallets on the designated area pallet storage racks according to the type of raw materials, preparing for the robot to load the materials.

[0029] Step 2.5: The oxidant raw material is sucked by the feeding robot one bag at a time and opened above the feeding hopper of the crushing device (equipped with a bag opening blade) and the raw material is added to the hopper. The empty bag is placed in the packaging bag collection tank. After the raw material is pre-crushed, it is fed into the crusher by the explosion-proof spiral feeder and falls into the storage hopper below after being crushed.

[0030] Step 2.6: The crushed material is pumped into the oxidant temporary storage and weighing device via the vacuum feeder. The vibrating feeder is activated to feed the material into the weighing hopper. Feeding stops when the weight reaches the set value. The vacuum feeder of the mixing system is activated to add the raw materials in the weighing hopper into the high-efficiency mixer.

[0031] Step 2.7: The reducing agent does not require a crushing process. The reducing agent is pumped into the reducing agent temporary storage weighing device via a vacuum feeder. The vibrating feeding mechanism is started to feed the material into the measuring hopper. Feeding is stopped when the weight reaches the set value. The vacuum feeder of the mixing system is started to add the raw materials in the measuring hopper into the high-efficiency mixer; the reducing agent and the oxidant are mixed.

[0032] Preferably, in step 2.7, a set of vacuum feeders is used for each of the oxidant and the reducing agent to prevent the raw materials from mixing in the feeding pipe. After the dry mixing is completed, the discharge valve of the No. 1 mixer is opened, and all the materials are placed in the No. 2 mixer. The No. 1 mixer is fed again to carry out the next batch of dry mixing.

[0033] Preferably, in step 3, after dry mixing, the feeding pump is started, and the adhesive is added to the No. 2 mixer through the pipeline, and the material is metered while being added. After the adhesive is added, wet mixing is performed, and after the wet mixing is completed, the discharge valve of the No. 2 mixer is opened to discharge the material.

[0034] Preferably, in step 4, a swing granulator is used for granulation, and the granulation process is as follows: the agent is added into the swing granulator for swing granulation, and the discharge speed is controlled by controlling the size of the discharge valve of the No. 2 mixer to achieve granulation while discharging.

[0035] Preferably, in step 5, the upper and lower boxes of the vibrating fluidized bed are insulated, the air supply duct and exhaust duct of the vibrating fluidized bed are insulated, and a methanol concentration detection sensor is set inside the box to monitor the methanol concentration in the box, and the detection signal is transmitted remotely to the automatic control system. If the set index is exceeded, the system alarms, and the feeding and hot air supply are stopped; the drying temperature is 65-70°C.

[0036] Preferably, the preparation system of the aerosol gas-generating drug preparation process mainly includes a raw material preparation system, a drug mixing system, a granulation system, a drying system, a screening system, a barreling system, a drug loading and pressing system, and a tableting system; in addition, it also includes a conveying system, a vacuum system, a hot water system, a pipeline valve meter system, a dehumidification system, an exhaust and dust removal system, a pneumatic control system, a video monitoring system, an explosion-proof wired intercom system, a compressed air system, a computer management system, an automatic control system, an equipment and device integration system, an information acquisition system, etc.

[0037] The raw material preparation system includes a resin temporary storage and weighing device, a vacuum loader, an adhesive preparation tank, a methanol high-level tank, an oxidant temporary storage and weighing device, a reducing agent temporary storage and weighing device, a crusher, an oxidant crushing device, an explosion-proof screw loader, a loading robot, raw material pallets, a pallet storage rack, an explosion-proof electric forklift, a packaging bag collection tank, a wet dust collector, an isolation window, and a methanol concentration sensor. The raw material preparation system is used to achieve the weighing, temporary storage, and crushing functions of raw materials.

[0038] The mixing system includes a high-efficiency mixer, a vacuum loader and a steel platform; the mixing system is used to achieve dry mixing and wet mixing of raw materials;

[0039] The granulation system includes a swing granulator and an elevator conveyor belt; the granulation system is used to prepare the wet medicine into granular medicine and transport the granular medicine to the screening system;

[0040] The drying system includes a horizontal vibrating fluidized bed, a drying feeding belt, a cooling belt, a cooling exhaust device, an explosion-proof axial flow fan and a methanol concentration detection sensor; the drying system is used to dry the granular medicine in a continuous manner;

[0041] The screening system includes a crushing device, a swing granulator, a vibrating screen and a pneumatic explosion-proof dust collector; the screening system is used to automatically screen the dried and cooled pharmaceuticals;

[0042] The weighing and barreling system includes a barreling belt, a weighing device, a truss manipulator, a tray positioning device, a lid placement device, a medicine barrel, and a finished product tray. The weighing and barreling system is used to automatically weigh and barrel qualified medicines.

[0043] The conveying system includes a medicine barrel transfer device, an elevator, a fireproof window and a belt line. The conveying system is used to transport the loaded medicine barrels to the medicine pressing room and tableting room, and transport the empty barrels back to the medicine filling station. The finished medicine columns are transported from the medicine pressing room and tableting room to the boxing room for manual boxing.

[0044] The drug charging and pressing system includes a drug barrel transmission mechanism, a drug barrel turning mechanism, a drug charging host, a press, a turntable assembly, and a finished product transmission mechanism. The drug charging and pressing system is used to press granular drugs into drug columns.

[0045] The tableting system is a modification based on the tableting machine, including the addition of a medicine barrel conveying mechanism and a finished product conveying mechanism to realize automatic loading and barreling of finished medicine pellets.

[0046] Preferably, the lid picking and placing device in the barrel filling system includes a gantry frame, and a translation cylinder and a slide rail are provided on the top of the gantry frame. The translation cylinder is used to drive the lifting cylinder to move, and the lifting cylinder slides with the slide rail. The lifting cylinder is used to drive the gripper to move up and down, and the gripper is used to clamp the medicine barrel cover.

[0047] Preferably, the medicine barrel transfer device includes a speed chain, on which a pallet is placed, and the pallet is used to place the medicine barrel; a barrel cover picking and placing device is provided above the speed chain, and a medicine barrel lifting and translating device is provided at the bottom of the speed chain, and the medicine barrel lifting and translating device is located below the pallet.

[0048] Preferably, the medicine barrel flipping mechanism includes a clamping device and a flipping drive device, the clamping device includes two symmetrically arranged arc-shaped clamping plates, the arc-shaped clamping plates are connected to the rotating rod, the outer wall of the rotating rod is provided with a convex strip, the rotating rod is connected to the telescopic rod of the clamping drive cylinder through a connecting tube, and the rotating rod rotates in coordination with the telescopic rod of the clamping drive cylinder; the flipping drive device is used to drive the rotating rod to rotate; the flipping drive device includes a sliding sleeve sleeved on the rotating rod, the sliding sleeve is provided with a through hole and a sliding groove, the sliding groove is adapted to the convex strip, the sliding sleeve is connected to the steering rod, and the steering rod is hinged to the telescopic rod of the flipping drive cylinder.

[0049] The present invention can achieve the following beneficial effects:

[0050] The present invention can realize the automated production of raw material crushing, adhesive preparation, feeding, mixing, granulation, drying, screening, weighing and barreling, coding and tableting, medicine pressing and logistics transmission. Except for coding of raw materials and delivering raw materials to designated locations, changing trays, changing tablets and medicine barrels, and medicine column packing, which are completed manually, other process actions of the production line are driven by cylinders or explosion-proof motors, and the actions are simple, practical and reliable. BRIEF DESCRIPTION OF THE DRAWINGS

[0051] The present invention will be further described below with reference to the accompanying drawings and examples:

[0052] FIG1 is a flow chart of a process for preparing an aerosol gas generating agent according to the present invention;

[0053] FIG2 is a planar layout diagram of the preparation system of the aerosol gas generating agent preparation process of the present invention;

[0054] FIG3 is a structural diagram of a raw material preparation system of the present invention;

[0055] FIG4 is a structural diagram of a temporary weighing device according to the present invention;

[0056] FIG5 is a diagram showing the weighing principle of the temporary weighing device of the present invention;

[0057] FIG6 is a diagram showing the connection structure of plates 1 and 2 of the temporary weighing device of the present invention;

[0058] FIG7 is a three-dimensional structural diagram of the medicine barrel transfer device of the present invention;

[0059] FIG8 is a three-dimensional structural diagram of the medicine barrel lifting and translation device of the present invention;

[0060] FIG9 is a schematic diagram of the structure of the medicine barrel turning mechanism of the present invention;

[0061] FIG10 is a driving principle diagram of the flip driving device of the present invention; FIG1

[0062] FIG11 is a second driving principle diagram of the flip driving device of the present invention.

[0063] In the figure: double-speed chain 1, pallet 2, gantry frame 301, translation cylinder 302, lifting cylinder 303, gripper 304, base 401, lifting cylinder 402, belt transmission mechanism 403, reduction motor 403.1, guide rod 404, arc-shaped clamping plate 501, rotating rod 502, ridge 503, connecting tube 504, clamping drive cylinder 505, sliding sleeve 506, slide 507, steering rod 508, flip drive cylinder 509, medicine barrel 6, resin temporary storage weighing device 7 , temporary storage bucket 701, vibrating feeding mechanism 702, electromagnetic vibrator 702.1, temporary storage bucket frame 703, weighing sensor 704, metering bucket 705, discharge valve 706, interface docking mechanism 707, weighing mechanism frame 708, side plate 709, positioning rod 710, plate 1 711, plate 2 712, rotation drive device 713, oxidant temporary storage weighing device 8, reducing agent temporary storage weighing device 9, loading robot 10, raw material tray 11, raw material bag 12;

[0064] Raw material preparation system A, mixing system B, granulation system C, drying system D, screening system E, barrel filling system F, charging and pressing system G and tableting system H. DETAILED DESCRIPTION

[0065] Example 1:

[0066] The preferred solution is shown in Figures 1 to 11, which is a process for preparing an aerosol gas-generating agent. The preparation process is as follows:

[0067] Step 1, raw material preparation: the raw materials include resin, methanol, oxidant and reducing agent;

[0068] Resin, methanol, oxidant and reducing agent are temporarily stored and accurately weighed using the resin temporary storage weighing device, methanol high-level tank, oxidant temporary storage weighing device and reducing agent temporary storage weighing device respectively.

[0069] The resin temporary storage and weighing device consists of a temporary storage hopper, a metering hopper, a weighing sensor, a vibrating feeding mechanism, a discharge valve, an interface docking mechanism, and a frame. The vibrating feeding mechanism's feed port is flexibly connected to the temporary storage hopper's lower outlet, and its discharge port is flexibly connected to the metering hopper's feed port. The vibrating feeding mechanism's own closed material channel is driven by an electromagnetic vibrator, enabling both rapid and slow, precise feeding. The metering hopper is mounted on an explosion-proof weighing sensor, enabling simultaneous feeding and weighing. Specifically, the device comprises a temporary storage hopper frame, with the temporary storage hopper mounted on top and a vibrating feeding mechanism mounted at its bottom. The vibrating feeding mechanism is connected to the metering hopper and used to feed material into it. The weighing sensor is mounted on top of the metering hopper, and a discharge valve is mounted at its bottom. The interface docking mechanism is located at the bottom of the discharge valve. The metering hopper is supported by the weighing mechanism frame. The vibrating feeding mechanism includes a delivery pipeline equipped with an electromagnetic vibrator, which uses frequency modulation to achieve both rapid and slow, precise feeding.

[0070] Step 2: Mix the raw materials:

[0071] 1) Mixing resin and methanol to prepare adhesive,

[0072] 2) crushing the oxidant;

[0073] 3) After weighing the oxidant and the reducing agent, dry mix the oxidant and the reducing agent;

[0074] The adhesive is prepared in an adhesive preparation tank, which includes a manhole and a feed port. The lower tank body is an interlayer and is equipped with a hot water inlet and outlet, a temperature sensor, and a pressure level gauge. The stirring paddle of the adhesive preparation tank adopts an anchor type stirring paddle.

[0075] Step 3, adding a binder to the mixture of the oxidizing agent and the reducing agent and wet mixing them to prepare a wet agent;

[0076] A high-efficiency mixer evenly mixes the added oxidizing agent, reducing agent, and adhesive to meet the requirements of the granulation process. The mixer's main components, including the tank, agitator, and cutter, are polished to prevent material from sticking to the surface. The rounded transitions throughout the surface make it easy to clean, with no dead zones. A pneumatic seal is used between the agitator shaft and the tank, effectively preventing dust ingress and cross contamination. An exhaust port is located on the tank lid, allowing for water or solvent cleaning after production.

[0077] Step 4, adding the wet agent into a granulator for granulation;

[0078] The reagent is added to the guide hopper of the swing granulator, and the swing granulator starts to swing granulate. The granulated reagent falls onto the lifting conveyor belt after passing through the collection hopper. The lifting conveyor belt is transported to the horizontal vibrating fluidized bed to begin drying. The swing granulator includes a hopper, a collection hopper, a screen, a drum, an explosion-proof motor reducer, a frame and a protective cover. The explosion-proof motor reducer drives the crank-connecting rod mechanism to make the horizontal rotor swing back and forth. A screen is installed under the rotor. The screen tensioning device has an automatic pre-tightening function, which makes the screen close to the rotor to achieve granulation. The screen is easy to disassemble, and the number of drum rotations can be set and adjusted, which can control the particle size and density of the particles to a certain extent. The swing granulation discharge port and the material belt connection are equipped with transparent protection, and a camera is installed to monitor the discharge of the swing granulator.

[0079] Step 5: The granulated medicine falls onto the lifting conveyor belt after passing through the collection bucket and is transported to the horizontal vibrating fluidized bed by the lifting conveyor belt to start drying;

[0080] The upper and lower boxes of the vibrating fluidized bed are insulated, and the air supply and exhaust ducts are insulated. A methanol concentration detection sensor is set at an appropriate position inside the box, which can be easily replaced to monitor the methanol concentration in the box and transmit the detection signal to the automatic control system. If the set index is exceeded, the system will alarm, and the feeding and hot air supply will be stopped.

[0081] Step 6: Cool the dried medicine, and then convey the cooled medicine to the crushing device via the cooling belt. The crushed medicine falls into the screening device for screening. The screened medicine falls onto the barreling belt and is conveyed backward.

[0082] Step 7: The qualified medicines are weighed at the medicine filling station and then packed into barrels;

[0083] Step 8: transport the loaded medicine barrels to the medicine pressing room, which is used to compress the loose medicine into medicine columns. The empty barrels are transported back to the medicine filling station in step 7.

[0084] Step 9, delivering the drug column to a tableting machine for tableting;

[0085] Step 10: Pack the tablets and the preparation process is completed.

[0086] Preferably, in step 2, the adhesive preparation needs to be carried out before dry mixing, and the sub-steps are as follows:

[0087] Step 2.1: When preparing the adhesive, manually stack the resin raw material bags on the pallet, then use a forklift to place the pallet on the designated area pallet storage rack according to the type of raw material, ready for the robot to load the material;

[0088] Step 2.2: The methanol required for preparing the adhesive is extracted into the methanol high-level tank by a vacuum pump under negative pressure. When the high-level tank is full, a certain amount of methanol is added to the adhesive preparation tank. A total of two extractions of methanol are required. Methanol measurement is achieved using a flow meter.

[0089] Step 2.3: The resin is sucked up one bag at a time by the feeding robot and opened above the feed port of the resin temporary storage and weighing device. The material is added to the measuring hopper by the vibration feeding mechanism and weighed while adding. When the weight reaches the set value, the feeding is stopped. Then the vacuum feeder is started to add the resin raw material in the measuring hopper to the corresponding adhesive preparation tank. At this time, the stirring paddle of the adhesive preparation tank is started, and hot water is added to the interlayer of the preparation tank to start circulation for temperature control.

[0090] Step 2.4: Manually stack the bags of oxidant and reductant raw materials required for production on pallets. Then, manually use a forklift to place the pallets on the designated area pallet storage racks according to the type of raw materials, preparing for the robot to load the materials.

[0091] Step 2.5: The oxidant raw material is sucked by the feeding robot one bag at a time, opened above the crushing device feeding hopper and the raw material is added to the hopper. The empty bag is placed in the packaging bag collection tank. After the raw material is pre-crushed, it is fed into the crusher by the explosion-proof screw feeder and falls into the storage hopper below after being crushed.

[0092] Step 2.6: The crushed material is pumped into the oxidant temporary storage and weighing device via the vacuum feeder. The vibrating feeder is activated to feed the material into the weighing hopper. Feeding stops when the weight reaches the set value. The vacuum feeder of the mixing system is activated to add the raw materials in the weighing hopper into the high-efficiency mixer.

[0093] Step 2.7: The reducing agent does not require a crushing process. The reducing agent is pumped into the reducing agent temporary storage weighing device via a vacuum feeder. The vibrating feeding mechanism is started to feed the material into the measuring hopper. Feeding is stopped when the weight reaches the set value. The vacuum feeder of the mixing system is started to add the raw materials in the measuring hopper into the high-efficiency mixer; the reducing agent and the oxidant are mixed.

[0094] Furthermore, in step 2.7, a set of vacuum feeders is used for each of the oxidant and the reducing agent to prevent the raw materials from mixing in the feeding pipe. After the dry mixing is completed, the discharge valve of the No. 1 mixer is opened, and all the materials are placed in the No. 2 mixer. The No. 1 mixer is fed again for the next batch of dry mixing.

[0095] Furthermore, in step 3, after dry mixing, the feeding pump is started, and the adhesive is added to the No. 2 mixer through the pipeline, and the material is metered while being added. After the adhesive is added, wet mixing is performed, and after the wet mixing is completed, the discharge valve of the No. 2 mixer is opened to discharge the material.

[0096] Furthermore, in step 4, a swing granulator is used for granulation, and the granulation process is as follows: the medicine is added into the swing granulator for swing granulation, and the discharge speed is controlled by controlling the size of the discharge valve of the No. 2 mixer to achieve granulation while discharging.

[0097] Furthermore, in step 5, the upper and lower boxes of the vibrating fluidized bed are insulated, the air supply duct and exhaust duct of the vibrating fluidized bed are insulated, and a methanol concentration detection sensor is set inside the box to monitor the methanol concentration in the box, and the detection signal is transmitted remotely to the automatic control system. If the set index is exceeded, the system alarms, and the feeding and hot air supply are stopped; the drying temperature is 65-70℃.

[0098] An aerosol gas-generating drug preparation system mainly includes a raw material preparation system, a drug mixing system, a granulation system, a drying system, a screening system, a barreling system, a drug charging and pressing system, and a tableting system;

[0099] 1. The raw material preparation system includes a resin temporary storage and weighing device, a vacuum loader, an adhesive preparation tank, a methanol high-level tank, an oxidizer temporary storage and weighing device, a reducing agent temporary storage and weighing device, a crusher, an oxidizer crushing device, an explosion-proof screw loader, a loading robot, a raw material pallet, a pallet storage rack, an explosion-proof electric forklift, a packaging bag collection tank, a wet dust collector, an isolation window and a methanol concentration sensor; the raw material preparation system is used to realize the weighing, temporary storage and crushing functions of the raw materials; the oxidizer temporary storage and weighing device, the reducing agent temporary storage and weighing device and the resin temporary storage and weighing device have the same structure and can be collectively referred to as "temporary storage and weighing devices." The temporary storage and weighing device includes a temporary storage bucket frame 703, with a temporary storage bucket 701 mounted on top of the frame 703. A vibrating feeding mechanism 702 is mounted at the bottom of the temporary storage bucket 701. The vibrating feeding mechanism 702 is connected to a metering bucket 705 and is used to feed material into the metering bucket. A weighing sensor 704 is mounted on the top of the metering bucket, a discharge valve 706 is mounted at the bottom of the metering bucket 705, and an interface docking mechanism 707 is mounted at the bottom of the discharge valve. The metering bucket is supported by a weighing mechanism frame 708. The temporary storage bucket 701 is used to store resin, reducing agent, or oxidizing agent. The vibrating feeding mechanism 702 is used to transfer the material from the temporary storage bucket 701 to the metering bucket 705. The metering bucket 705 is equipped with a weighing mechanism for weighing the material.

[0100] Specifically, the vibrating feeding mechanism includes a conveying pipe equipped with an electromagnetic vibrator 702.1, which uses frequency modulation to achieve both rapid and slow, precise feeding. A weighing sensor is mounted on a side plate 709, which is mounted on top of the weighing hopper. A positioning rod 710 is provided on the side plate, which slidably engages with plate 1 711. Plate 1 711 is connected to plate 2 712 via a rotating shaft, and plate 2 is driven to rotate by a rotation drive 713. Rotation drive 713 can be a pneumatic cylinder, which drives plate 2 712 and is integrally mounted to the cylinder. Rotation drive 713 can be a motor, which drives plate 2 via a rotating shaft and is integrally mounted to plate 2 712. As shown in Figure 3, plates 1 711 and 712 are connected as a single unit, with the entire weight bearing on the weighing sensor 704. Positioning rod 710 extends through plate 1 711 to prevent movement. After each weighing, the driving device 713 is rotated to put the raw materials into the bottom of the measuring hopper 705. The raw materials are then discharged through the discharge valve 706. There are multiple positioning rods 710, and the weighing sensors are installed in the middle of several positioning rods 710.

[0101] 2. The mixing system includes a high-efficiency mixer, a vacuum loader and a steel platform; the mixing system is used to achieve dry mixing and wet mixing of raw materials;

[0102] 3. The granulation system includes a swing granulator and an elevator conveyor belt; the granulation system is used to prepare the wet agent into granular agents and transport the granular agents to the screening system;

[0103] The drying system includes a horizontal vibrating fluidized bed, a drying feed conveyor, a cooling conveyor, a cooling exhaust system, an explosion-proof axial flow fan, and a methanol concentration sensor. The drying system is used to dry granular pharmaceuticals inline. The drying system consists of a horizontal vibrating fluidized bed, a drying feed conveyor, a cooling conveyor, an explosion-proof axial flow fan, and a methanol concentration sensor. The horizontal vibrating fluidized bed comprises a main unit, a hot air unit, and a cyclone separator. The upper and lower chambers of the vibrating fluidized bed are insulated, as are the supply and exhaust ducts. A methanol concentration sensor is conveniently located within the chamber, allowing for easy replacement. It monitors the methanol concentration within the chamber and transmits a signal to the automatic control system. If the concentration exceeds the set limit, the system alarms, halting feeding and hot air supply. The drying feed conveyor is constructed of corrosion-resistant and antistatic material with side ribs. The frame is constructed of spliced ​​aluminum profiles or welded carbon steel. The belt width is 0.5m and the length is 1m. The belt length and lifting height can be adjusted to match the connecting equipment. The drive is an explosion-proof motor. The cooling belt conveyor is constructed from corrosion-resistant and antistatic material with side ribs. The frame is constructed from spliced ​​aluminum profiles or welded carbon steel. The belt width is 0.5m and the length is 8m. The belt length and lifting height are adjusted to match the connecting equipment. The conveyor is driven by an explosion-proof motor. A transition channel is installed at the initial feed end of the belt, which is softly connected to the vibrating fluidized bed to prevent material spillage during the discharge process.

[0104] The screening system includes a crushing unit, a swing granulator, a vibrating screen, and a pneumatic explosion-proof dust collector. The screening system automatically screens the dried and cooled reagents. The dried and cooled reagents are conveyed via a cooling belt to the crushing unit, where they fall into the swing granulator for screening. The vibrating screen is located below the swing granulator's discharge port. After passing through the vibrating screen, the screened reagents fall onto the barrel loading belt and are then transported back. The crushing unit is a high-efficiency roller-type crushing structure, consisting of a crushing mechanism and a frame, and is driven by an explosion-proof motor. Guards are installed at the upper feed port and the cooling belt outlet, and the bottom discharge port is hermetically connected to the swing granulator to prevent dust from flying.

[0105] The weighing and barreling system includes a barreling conveyor, weighing device, truss manipulator, pallet positioning device, lid pick-and-place device, medicine barrels, and finished product pallets. This system automatically weighs and barrels qualified pharmaceuticals. The truss manipulator places the medicine barrel on an empty pallet on the conveyor line. The lid pick-and-place device removes the barrel lid, and the barrel is conveyed to the bottom of the swing granulator's discharge port. The weighing device's lifting cylinder drives the load cell and the medicine barrel upward, completing the barreling process. The system weighs the medicine as it is loaded. When the weight of the medicine in the barrel reaches the set value, feeding stops. The conveyor line's position change device switches the full barrel to the next empty barrel, and the next empty barrel is loaded. After the full barrel is capped, it is conveyed back to the tableting or tableting process. When backhauling is no longer necessary, the truss manipulator removes the medicine barrel from the off-line and places it on a pallet. The truss manipulator then grabs another empty barrel and brings it back online for loading. This cycle completes the loading of all medicine barrels. When all the medicine barrels on the pallet are full, the system alarm prompts the operator to drive a forklift to replace the pallet and deliver the medicine to the warehouse.

[0106] The barrel lid removal and placement device includes a gantry frame 301, topped with a translation cylinder 302 and a slide rail. The translation cylinder 302 drives the lift cylinder 303, which slides in conjunction with the slide rail. The lift cylinder 303 drives the gripper 304 up and down, which grips the barrel lid. The gantry frame 301 is mounted on the periphery of the double-speed chain 1. The gripper 304, which can be a pneumatic clamp, grips the barrel lid. The lift cylinder 303 drives the gripper 304 up and down, while the translation cylinder 302 drives the gripper 304 laterally. This process completes the removal of the barrel lid. The process for closing the barrel lid is the reverse.

[0107] The truss manipulator has a gantry-style structure, comes in one set, and is made of carbon steel. It consists of columns, a crossbeam, grippers, guide rails, rack and pinion gears, rollers, cylinders, servo motors, and reducers. The servo motor and reducer drive gears, used in conjunction with the rack, enable multi-position stops on the X and Y axes. The Z axis is pneumatically driven for lifting and lowering, and the grippers are pneumatically driven for clamping. The X-axis grasping span is 3.5 meters, and the Y-axis grasping span is 5.5 meters. The X- and Y-axis guide rail terminals are equipped with in-situ detection switches, overtravel detection switches, and overtravel limit buffer columns to ensure safe truss operation.

[0108] 7. The conveying system includes a medicine barrel transfer device, an elevator, a fireproof window and a belt line; the conveying system is used to transport the loaded medicine barrels to the medicine pressing room and tableting room, and transport the empty barrels back to the medicine filling station. The finished medicine columns are transported from the medicine pressing room and tableting room to the boxing room for manual boxing;

[0109] The medicine barrel transfer device includes a speed chain 1, on which a tray 2 is placed, and on which the medicine barrel is placed; a device for taking and placing the barrel cover is provided above the speed chain 1, and a medicine barrel lifting and translation device is provided at the bottom of the speed chain 1. In conjunction with Figure 1, the medicine barrel lifting and translation device is located below the tray 2. The bottom of the tray 2 can be provided with convex teeth, which are used to engage with the chain of the speed chain 1 to prevent the tray 2 from sliding.

[0110] The medicine barrel lifting and translation device includes a base 401, with a lifting cylinder 402 located at its base. This cylinder drives a belt drive mechanism 403, which includes a frame, a drive belt, and a pulley. The belt is driven by a reduction motor 403.1. The medicine barrel lifting and translation device is used to transfer medicine barrels to the pressing room. Lifting cylinder 402 lifts tray 2 and the medicine barrel, activating belt drive mechanism 403 to translate the medicine barrel.

[0111] The bottom of the frame of the belt transmission mechanism 403 is provided with a guide rod 404, which is slidably matched with the base 401. The base 401 is provided with a guide hole, which is slidably matched with the guide rod 404 to improve the stability of the belt transmission mechanism 403 moving up and down.

[0112] 8. The drug loading and pressing system includes a drug barrel transmission mechanism, a drug barrel turning mechanism, a drug loading host, a press, a turntable assembly, and a finished product transmission mechanism. The drug loading and pressing system is used to press granular drugs into drug columns;

[0113] Specifically, the medicine barrel tilting mechanism includes a clamping device and a tilting drive mechanism. The clamping device comprises two symmetrically arranged curved clamping plates 501, which are connected to a rotating rod 502. The rotating rod 502 has a ridge 503 on its outer wall. The rotating rod 502 is connected to the telescopic rod of the clamping drive cylinder 505 via a connecting tube 504, and the rotating rod 502 and the telescopic rod of the clamping drive cylinder 505 rotate in unison. The tilting drive mechanism is used to rotate the rotating rod 502. The two curved clamping plates 501 are used to clamp the medicine barrel. Preferably, the inner walls of the curved clamping plates 501 may be coated with friction-enhancing glue. The connecting tube 504 connects the rotating rod 502 to the telescopic rod of the clamping drive cylinder 505, while also ensuring that the rotating rod 502 can rotate. The connecting tube 504 is fixed to the equipment frame via a base, and the clamping drive cylinder 505 is also fixed to the equipment frame.

[0114] The tilt drive mechanism includes a sleeve 506 that fits over the rotating rod 502. The sleeve 506 is equipped with a through-hole and a slot 507 that mates with a ridge 503. The sleeve 506 is connected to a steering rod 508, which is hingedly connected to the telescopic rod of the tilt drive cylinder 509. Two ridges 503 are welded to the outer wall of the rotating rod 502, and two slots 507 are defined within the inner wall of the sleeve 506. The sleeve 506 can slide along the rotating rod 502 while also cooperating with the steering rod 508 and the tilt drive cylinder 509 to rotate the rotating rod 502. The rear end of the tilt drive cylinder 509 is connected to the equipment frame via a rotating shaft.

[0115] One end of the connecting tube 504 is connected to the telescopic rod of the clamping drive cylinder 505 through a tapered bearing, and the other end of the connecting tube 504 is fixedly connected to the rotating rod 502. The tapered bearing can bear a large axial thrust.

[0116] 9. The tableting system is a modification based on the tableting machine, including the addition of a medicine barrel transmission mechanism and a finished product transmission mechanism to achieve automatic loading and the loading and unloading of finished medicine pellets into barrels.

[0117] The above embodiments are merely preferred technical solutions of the present invention and should not be construed as limiting the present invention. The scope of protection of the present invention shall be the technical solutions set forth in the claims, including equivalent alternatives to the technical features of the technical solutions set forth in the claims. In other words, equivalent alternatives and improvements within this scope are also within the scope of protection of the present invention.

Claims

1. A process for preparing an aerosol gas generating agent, characterized in that: Step 1, raw material preparation: the raw materials include resin, methanol, oxidant and reducing agent; Step 2, mix the raw materials: 1) Mixing the resin with methanol to prepare an adhesive, 2) crushing the oxidant; 3) After weighing the oxidant and the reductant, dry mix the oxidant and the reductant; Step 3, adding a binder to the mixture of the oxidant and the reductant and wet mixing them to prepare a wet agent; Step 4, adding the wet agent into the granulator for granulation, Step 5, the granulated medicine falls onto the lifting conveyor belt after passing through the collecting bucket, and is transported by the lifting conveyor belt to the horizontal vibrating fluidized bed for drying; Step 6, cooling the dried medicine, conveying the cooled medicine to the crushing device via the cooling belt, and the crushed medicine falls into the screening device for screening; the screened medicine falls onto the barreling belt and is conveyed backward; Step 7, weigh the qualified medicines at the medicine filling station, and then fill them into barrels after weighing; Step 8, transport the loaded medicine barrels to the medicine pressing room, which is used to compress the loose medicine into medicine columns, and transport the empty barrels back to the medicine loading station in step 7; Step 9, sending the drug column to a tableting machine to tablet the drug column; Step 10, the tablets are packaged and the preparation process is completed.

2. The process for preparing aerosol gas generating agent according to claim 1, characterized in that: In step 2, the adhesive preparation needs to be carried out before dry mixing, and the sub-steps are as follows: Step 2.1: When preparing the adhesive, manually stack the resin raw material bags on the pallet, and then use a forklift to place the pallet on the designated area pallet storage rack according to the type of raw material, ready for the robot to load the material; Step 2.2, the methanol required for preparing the adhesive is extracted into the methanol high-level tank by the vacuum pump under negative pressure. After the high-level tank is full, a certain amount of methanol is added into the adhesive preparation tank. A total of two extractions of methanol are required, and the methanol metering is achieved by using a flow meter; Step 2.3, the feeding robot takes one bag of resin each time and opens the bag above the feeding port of the resin temporary storage weighing device. The vibrating feeding mechanism adds the material into the measuring bucket and weighs while adding. When the weight reaches the set value, the feeding is stopped. Then the vacuum feeder is started to add the resin raw material in the measuring bucket into the corresponding adhesive preparation tank. At this time, the stirring paddle of the adhesive preparation tank is started, and the hot water in the interlayer of the preparation tank starts to circulate for temperature control; Step 2.4: Manually stack the oxidant raw material bags and reductant raw material bags required for production on pallets, and then manually drive a forklift to place the pallets on the pallet storage racks in the designated area according to the types of raw materials, preparing for the robot to load the materials; Step 2.5: The feeding robot takes one bag of oxidant raw material at a time, opens the bag above the crushing device hopper and places the raw material Add the bags into the hopper, and put the empty bags into the packaging bag collection tank. After the raw materials are pre-crushed, they are sent to the crusher by the explosion-proof screw feeder, and then fall into the storage hopper below after being crushed. Step 2.6, the crushed material is pumped into the oxidant temporary storage weighing device through the vacuum feeder, the vibration feeder mechanism is started to feed the material into the measuring bucket, and the feeding is stopped when the weight reaches the set value, and the vacuum feeder of the mixing system is started to add the raw materials in the measuring bucket into the high-efficiency mixer; Step 2.7, the reducing agent does not require a crushing process. The reducing agent is pumped into the reducing agent temporary storage weighing device through a vacuum feeder, and the vibrating feeding mechanism is started to feed the material into the measuring bucket. When the weight reaches the set value, the feeding is stopped. The vacuum feeder of the mixing system is started to add the raw materials in the measuring bucket into the high-efficiency mixer; the reducing agent and the oxidant are mixed.

3. The process for preparing aerosol gas generating agent according to claim 2, characterized in that: In step 2.7, a set of vacuum feeders is used for each of the oxidant and the reductant to prevent the raw materials from mixing in the feeding pipe. After the dry mixing is completed, the discharge valve of the No. 1 mixer is opened, and all the materials are placed in the No. 2 mixer. The No. 1 mixer is fed again for the next batch of dry mixing.

4. The process for preparing aerosol gas generating agent according to claim 3, characterized in that: In step 3, after dry mixing, the feed pump is started, and the adhesive is added to the No. 2 mixer through the pipeline, and the material is metered while being added. After the adhesive is added, wet mixing is performed. After the wet mixing is completed, the discharge valve of the No. 2 mixer is opened to discharge the material.

5. The process for preparing aerosol gas generating agent according to claim 4, characterized in that: In step 4, a swing granulator is used for granulation, and the granulation process is as follows: the agent is added into the swing granulator for swing granulation, and the discharge speed is controlled by controlling the size of the discharge valve of the No. 2 mixer to achieve granulation while discharging.

6. The process for preparing aerosol gas generating agent according to claim 1, characterized in that: In step 5, the upper and lower boxes of the vibrating fluidized bed are insulated, the air supply duct and exhaust duct of the vibrating fluidized bed are insulated, and a methanol concentration detection sensor is set inside the box to monitor the methanol concentration in the box, and the detection signal is transmitted remotely to the automatic control system. If the set index is exceeded, the system alarms, and the feeding and hot air supply are stopped; the drying temperature is 65-70℃.

7. The preparation system of the aerosol gas generating agent preparation process according to claim 1, characterized in that: It mainly includes raw material preparation system, drug mixing system, granulation system, drying system, screening system, barrel filling system, drug loading and pressing system and tableting system; The raw material preparation system includes a resin temporary storage weighing device, a vacuum feeder, an adhesive preparation tank, a methanol high-level tank, an oxidant temporary storage weighing device, a reducing agent temporary storage weighing device, a crusher, an oxidant crushing device, an explosion-proof spiral feeder, a feeding robot, a raw material tray, a tray storage rack, an explosion-proof electric forklift, a packaging bag collection tank, a wet dust collector, an isolation window and a methanol concentration sensor; the raw material preparation system is used to realize the weighing, temporary storage and crushing functions of the raw materials; The mixing system includes a high-efficiency mixer, a vacuum feeder and a steel platform; the mixing system is used to achieve dry mixing and wet mixing of raw materials; The granulation system includes a swing granulator and a lifting conveyor belt; the granulation system is used to prepare the wet medicine into granular medicine and The granular medicine is delivered to the screening system; The drying system includes a horizontal vibrating fluidized bed, a drying feeding belt, a cooling belt, a cooling exhaust device, an explosion-proof axial flow fan and a methanol concentration detection sensor; the drying system is used to dry the granular medicine inline; The screening system includes a crushing device, a swing granulator, a vibrating screen and a pneumatic explosion-proof dust collector; the screening system is used to automatically screen the dried and cooled medicines; The weighing and barreling system includes a barreling belt, a weighing device, a truss manipulator, a pallet positioning device, a cover pick-up and placement device, a medicine barrel and a finished product pallet. The weighing and barreling system is used to automatically weigh and barrel the qualified medicines. The conveying system includes a medicine barrel transfer device, a hoist, a fireproof window and a belt line; the conveying system is used to transport the loaded medicine barrels to the medicine pressing room and the tableting room, transport the empty barrels back to the medicine loading station, and transport the finished medicine columns from the medicine pressing room and the tableting room to the boxing room for manual boxing; The medicine loading and pressing system includes a medicine barrel transmission mechanism, a medicine barrel turning mechanism, a medicine loading host, a press, a turntable assembly, and a finished product transmission mechanism. The medicine loading and pressing system is used to press granular medicine into medicine columns; The tableting system is a modification based on the tableting machine, including the addition of a medicine barrel transmission mechanism and a finished product transmission mechanism to achieve automatic loading and barreling of finished medicine pellets.

8. The preparation system of the aerosol gas generating agent preparation process according to claim 7, characterized in that: The cover taking and placing device in the barrel filling system comprises a gantry frame (301), and a translation cylinder (302) and a slide rail are arranged on the top of the gantry frame (301). The translation cylinder (302) is used to drive a lifting cylinder (303) to move, and the lifting cylinder (303) and the slide rail are slidably matched. The lifting cylinder (303) is used to drive a gripper (304) to move up and down, and the gripper (304) is used to clamp the medicine barrel cover.

9. The preparation system of the aerosol gas generating agent preparation process according to claim 8, characterized in that: The medicine barrel transfer device comprises a double-speed chain (1), on which a tray (2) is placed, and the tray (2) is used to place the medicine barrel; a barrel cover taking and placing device is provided above the double-speed chain (1), and a medicine barrel lifting and translation device is provided at the bottom of the double-speed chain (1), and the medicine barrel lifting and translation device is located below the tray (2).

10. The preparation system of the aerosol gas generating agent preparation process according to claim 8, characterized in that: The medicine barrel flipping mechanism comprises a clamping device and a flipping driving device, wherein the clamping device comprises two symmetrically arranged arc-shaped clamping plates (501), the arc-shaped clamping plates (501) are connected to a rotating rod (502), a convex strip (503) is provided on the outer wall of the rotating rod (502), the rotating rod (502) is connected to the telescopic rod of the clamping driving cylinder (505) through a connecting tube (504), and the rotating rod (502) and the telescopic rod of the clamping driving cylinder (505) are rotationally matched; The flip driving device is used to drive the rotating rod (502) to rotate; the flip driving device comprises a sliding sleeve (506) sleeved on the rotating rod (502), the sliding sleeve (506) is provided with a through hole and a sliding groove (507), the sliding groove (507) is adapted to the convex strip (503), the sliding sleeve (506) is connected to the steering rod (508), and the steering rod (508) is hinged to the telescopic rod of the flip driving cylinder (509).

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