Cosmetic

Abstract

The present invention provides a cosmetic that exhibits an excellent use sensation. The cosmetic according to the present invention comprises (A) an N-acylmethyltaurine salt, (B) a linear higher alcohol, (C) a pyrimidylpyrazole compound represented by formula (1) or a salt thereof, (D) an oil component, and (E) water.

Description

cosmetics

[0001] The present invention relates to a cosmetic preparation. Specifically, the present invention relates to a cosmetic preparation comprising a pyrimidylpyrazole compound or a salt thereof.

[0002] Pigmentation such as age spots and freckles on the skin occurs when hormonal abnormalities or ultraviolet light stimulate the skin, resulting in increased melanin production in epidermal pigment cells and excessive melanin deposition in the epidermis. To prevent or improve such abnormal melanin deposition, whitening agents are incorporated into cosmetics. Various ingredients are known to be incorporated as whitening agents, and in recent years, pyrimidylpyrazole compounds have also been known as useful whitening agents (see, for example, Patent Document 1).

[0003] Oil-in-water emulsion cosmetics are widely used as bases for topical skin preparations, including skin cosmetics, due to their refreshing feel. However, emulsions are inherently unstable, and are known to experience creaming, aggregation, or coalescence when left for extended periods. Conventional lotions and creams have ensured stability over time by incorporating common water-soluble thickeners such as carboxyvinyl polymers. However, incorporating large amounts of water-soluble thickeners makes it difficult to eliminate sliminess, heavy spread, stickiness, and creasing upon application. Therefore, a cosmetic that provides a refreshing, penetrating feel without a slimy feel has been proposed by combining polyoxyethylene fatty acid sorbitan, a specific surfactant, and a higher alcohol (see, for example, Patent Document 2).

[0004] International Publication No. 2009 / 099192, Japanese Patent Application Laid-Open No. 2008-88129

[0005] The present inventors have surprisingly found that an excellent feeling when used can be achieved by using a cosmetic containing a combination of a pyrimidylpyrazole compound or a salt thereof, an N-acylmethyltaurine salt, and a linear higher alcohol. The present invention is based on these findings.

[0006] According to the present invention, the following inventions are provided: [1] A cosmetic comprising (A) an N-acylmethyltaurine salt, (B) a linear higher alcohol, (C) a pyrimidylpyrazole compound represented by formula (1) or a salt thereof, (D) an oil, and (E) water. (In the formula, R １ , R ３ , R ４ and R ６ are each independently C １－３ is an alkyl group, and R ２ and R ５ are each independently a hydrogen atom or C １－３ [2] R is an alkyl group ２ and R ５ [3] The cosmetic preparation according to [1], wherein R is a hydrogen atom. １ , R ３ , R ４ and R ６ is a methyl group. [4] The cosmetic preparation according to any one of [1] to [3], wherein component (A) is sodium stearoyl methyl taurate. [5] The cosmetic preparation according to any one of [1] to [4], wherein the blending amount of component (C) is 0.1 to 1.5 mass% relative to the total amount of the cosmetic preparation. [6] The cosmetic preparation according to any one of [1] to [5], wherein the viscosity measured at 30°C using a Brookfield type rotational viscometer is 6,000 mPa s or more. [7] The cosmetic preparation according to any one of [1] to [6], wherein the cosmetic preparation is an oil-in-water emulsion cosmetic preparation.

[0007] According to the present invention, it is possible to provide a cosmetic preparation that has an excellent feel when used, and in particular, it is possible to give a feeling of good spreadability during application and to impart a moist feeling to the skin after application. Specific Description of the Invention

[0008] The present invention relates to a cosmetic comprising (A) an N-acylmethyltaurine salt, (B) a linear higher alcohol, (C) a pyrimidylpyrazole compound having a specific structure or a salt thereof, (D) an oil, and (E) water.

[0009] (A) N-Acylmethyl Taurine Salt The cosmetic preparation according to the present invention comprises (A) an N-acylmethyl taurine salt. Component (A) includes an N-acyltaurine salt having an acyl group having 14 to 22 carbon atoms. Specific examples include N-stearoylmethyl taurine salt, N-palmitoylmethyl taurine salt, and N-myristoylmethyl taurine salt, with N-stearoylmethyl taurine salt being preferred. Preferred counter ions include sodium, potassium, triethanolamine, and the like. Component (A) is preferably sodium N-stearoylmethyl taurine.

[0010] The component (A) may be blended in one type or two or more types. The blending amount of the component (A) is preferably 0.01 to 3 mass %, more preferably 0.05 to 2 mass %, and even more preferably 0.3 to 1.5 mass %, relative to the total amount of the cosmetic.

[0011] (B) Straight-Chain Higher Alcohol The cosmetic preparation according to the present invention comprises (B) a straight-chain higher alcohol. Component (B) is preferably a higher alcohol having 14 to 22 carbon atoms and a straight-chain saturated alkyl group. Examples of component (B) include myristyl alcohol, cetyl alcohol, stearyl alcohol, and behenyl alcohol. Component (B) is preferably cetyl alcohol, stearyl alcohol, or behenyl alcohol.

[0012] The component (B) may be blended in one or more types. The blending amount of the component (B) is preferably 0.1 to 10% by mass, more preferably 0.5 to 8% by mass, and even more preferably 1 to 5% by mass, relative to the total amount of the cosmetic.

[0013] (C) Pyrimidylpyrazole Compound or Salt Thereof The cosmetic composition according to the present invention comprises (C) a pyrimidylpyrazole compound represented by formula (1) or a salt thereof. In the formula, R １ , R ３ , R ４ and R ６ are each independently C １－３R is an alkyl group, specifically a methyl group, an ethyl group, an n-propyl group, an isopropyl group, or a cyclopropyl group, preferably a methyl group or an ethyl group, and more preferably a methyl group. ２ and R ５ are each independently a hydrogen atom or C １－３ It is an alkyl group, specifically a hydrogen atom, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, or a cyclopropyl group, preferably a hydrogen atom, a methyl group, or an ethyl group, more preferably a hydrogen atom.

[0014] Component (C) may be a salt of the pyrimidylpyrazole compound represented by formula (1). The type of salt is not particularly limited as long as it is pharmaceutically acceptable, and may be an inorganic salt or an organic salt. Examples of salts include hydrochloride, hydrobromide, sulfate, phosphate, acetate, propionate, citrate, lactate, oxalate, maleate, fumarate, tartrate, and methanesulfonate. Component (C) is preferably dimethylpyrazolyldimethylpyrimidine hydrochloride.

[0015] The component (C) may be blended in one or more types. The blending amount of the component (C) is preferably 0.1 to 1.5 mass%, more preferably 0.3 to 1.3 mass%, and even more preferably 0.4 to 1.2 mass%, relative to the total amount of the cosmetic.

[0016] (D) Oil The cosmetic composition according to the present invention comprises an oil (D). Examples of the component (D) include silicone oil, hydrocarbon oil, and ester oil, with ester oil being preferred. Note that in the present invention, the component (D) does not include the component (B).

[0017] Examples of silicone oils include linear polysiloxanes (e.g., dimethicone, diphenylsiloxyphenyltrimethicone, diphenylpolysiloxane, etc.), cyclic polysiloxanes (e.g., octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, etc.), silicone resins that form a three-dimensional network structure, silicone rubber, various modified polysiloxanes (amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc.), and acrylic silicones, with linear polysiloxanes being preferred.

[0018] Examples of hydrocarbon oils include isododecane, isohexadecane, isoparaffin, mineral oil (liquid paraffin), ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, and hydrogenated polydecene.

[0019] Examples of ester oils include octyl octanoate, nonyl nonanoate, cetyl octanoate, isopropyl myristate (isopropyl myristate), octyldodecyl myristate, isopropyl palmitate, ethylhexyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, and isocetyl isostearate. Cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, tripropylene glycol pivalate, diisostearyl malate, glycerin di-2-heptylundecanoate, glycerin diisostearate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate Ingredients: propane, pentaerythrityl tetraethylhexanoate, glycerin tri-2-ethylhexanoate, glycerin trioctanoate, glycerin triisopalmitate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate-2-ethylhexyl palmitate, glycerin trimyristate, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleyl oleate, acetoglyceride, 2-heptylundecanoic acid palmitate Examples of suitable oils include hydroxypropyl acrylate, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, triethyl citrate, cetyl ethylhexanoate, and macadamia nut fatty acid phytosteryl.

[0020] The component (D) may be blended in one or more types. The blending amount of the component (D) is preferably 10 to 40 mass %, more preferably 15 to 30 mass %, based on the total amount of the cosmetic.

[0021] (E) Water The cosmetic according to the present invention comprises (E) water. As the water, water used in cosmetics, quasi-drugs, etc. can be used, such as purified water, ion-exchanged water, tap water, etc. The blending amount of water is preferably 40 to 90% by mass, more preferably 50 to 80% by mass, based on the total amount of the cosmetic according to the present invention.

[0022] In addition to the above-mentioned components, the cosmetic of the present invention can contain optional components typically used in cosmetics and pharmaceuticals, such as moisturizers, lower alcohols, sequestering agents, neutralizing agents, pH adjusters, antioxidants, preservatives, drugs, ultraviolet absorbers, powder components, fragrances, etc. One or more of these can be contained as long as the effects of the present invention are achieved.

[0023] The formulation of the cosmetic according to the present invention is not particularly limited, but it is preferably in the form of an oil-in-water emulsion cosmetic. In an oil-in-water emulsion cosmetic, the external phase that first comes into contact with the skin is the aqueous phase, which gives the skin a fresh feeling and makes it possible to more effectively experience the effects of the present invention.

[0024] Examples of cosmetics according to the present invention include skin care cosmetics (e.g., lotions, emulsions, creams, serums, packs, masks, etc.), makeup cosmetics (e.g., foundations, makeup bases, etc.), skin cleansers (e.g., facial cleansers, makeup removers, etc.), sunscreen cosmetics, ointments, etc. In a preferred embodiment, the cosmetic according to the present invention is a cream, which allows the effects of the present invention to be more clearly felt. Note that these forms are merely examples, and the cosmetic according to the present invention is not limited to these forms.

[0025] The viscosity of the cosmetic used in the present invention, measured at 30°C using a B-type rotational viscometer, is preferably 6,000 mPa·s or more, and more preferably 6,000 to 14,000 mPa·s. The cosmetic of the present invention is not particularly limited by the emulsification method, and can be produced according to a conventional method.

[0026] The present invention will be described in detail based on the following examples, but the present invention is not limited to these examples. Unless otherwise specified, the contents are expressed in mass % relative to the total amount.

[0027] [Examples 1 and 2 and Comparative Example 1] Oil-in-water emulsion cosmetics of Examples 1 and 2 and Comparative Example 1 were prepared according to the formulations shown in Table 1.

[0028] [Viscosity] The viscosity of the cosmetic material prepared above was measured using a Brookfield viscometer (No. 4 rotor, rotation speed 12 rpm) at 30° C. The results obtained are shown in Table 1.

[0029] [Evaluation of Usability] Five expert panelists applied the cosmetics of Examples 1 and 2 prepared above to their skin and evaluated the "moisturizing" of the skin after application and the "ease of spreading" during application, using the cosmetic of Comparative Example 1 as a standard. The number of people who rated the cosmetics as feeling "moisturizing" / "ease of spreading" better than the standard is shown in Table 1.

Claims

1. A cosmetic comprising: (A) an N-acylmethyltaurine salt; (B) a linear higher alcohol; (C) a pyrimidylpyrazole compound represented by formula (1) or a salt thereof; (D) an oil; and (E) water. (In the formula, R １ , R ３ , R ４ and R ６ are each independently １－３ R is an alkyl group; ２ and R ５ Each independently represents a hydrogen atom or C １－３ is an alkyl group) 2. R ２ and R ５ The cosmetic preparation according to claim 1 , wherein is a hydrogen atom.

3. R １ , R ３ , R ４ and R ６ The cosmetic preparation according to claim 1 or 2, wherein is a methyl group.

4. A cosmetic preparation according to claim 1 or 2, wherein component (A) is sodium stearoyl methyl taurate.

5. The cosmetic according to claim 1 or 2, wherein the blending amount of component (C) is 0.1 to 1.5 mass% based on the total amount of the cosmetic.

6. The cosmetic preparation according to claim 1 or 2, which has a viscosity of 6,000 mPa·s or more as measured at 30° C. using a B-type rotational viscometer.

7. The cosmetic according to claim 1 or 2, which is an oil-in-water emulsion cosmetic.

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