Extractor

Abstract

Provided is an extractor. The extractor comprises a pipetting unit and a workbench. A pipette placing part and a sample placing part are provided on the workbench. The pipetting unit comprises a fixed support, a first moving support, and a second moving support; a first driving apparatus is provided between the fixed support and the first moving support; a second driving apparatus is provided between the first moving support and the second moving support; the second moving support comprises a first moving assembly, a second moving assembly, and a third moving assembly which are slidably connected in sequence; and the first moving assembly is connected to the first moving support. The pipetting unit further comprises a third driving apparatus; and the third driving apparatus is configured to drive the second moving assembly to move up and down relative to the first moving assembly and drive the third moving assembly to move up and down relative to the second moving assembly. The extractor further comprises a vacuum module. The extractor can be adapted to pipettes of various lengths, and has a wide application.

Description

Extractor

[0001] This application claims priority to Chinese patent applications CN202420265008.X, CN202410153583.5, and CN202420265207.0, filed February 2, 2024. This application incorporates the entirety of the aforementioned Chinese patent applications. Technical Field

[0002] The present invention relates to biochemical equipment, in particular to an extraction instrument. Background Art

[0003] The extraction and purification of biological extracts is a critical technique widely used in biochemical research applications, typically performed using an extractor. During the extraction process, the pipette unit within the extractor moves up and down to draw up the liquid to be processed for further processing. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to overcome the requirement of the internal pipetting unit of the extractor in the prior art for pipetting up and down liquids, and to provide a new extractor.

[0005] The present invention solves the above technical problems through the following technical solutions:

[0006] The present invention provides an extractor, comprising a pipetting unit and a workbench, wherein the workbench is provided with a pipette placement portion and a sample placement portion, wherein the pipette placement portion is used to place unused pipettes, and the sample placement portion is used to place a sample solution to be processed;

[0007] The pipetting unit comprises:

[0008] Fixed bracket;

[0009] a first moving bracket, wherein a first driving device is provided between the fixed bracket and the first moving bracket, and the first driving device is used to drive the first moving bracket to move horizontally along a first direction relative to the fixed bracket;

[0010] a second motion bracket, wherein a second driving device is provided between the first motion bracket and the second motion bracket, and the second driving device is used to drive the second motion bracket to move horizontally relative to the first motion bracket in a second direction, wherein the second direction is perpendicular to the first direction;

[0011] The second motion bracket includes a first motion component, a second motion component and a third motion component that are slidably connected in sequence, and the first motion component is connected to the first motion bracket;

[0012] The pipetting unit further includes a third driving device, the third driving device being used to drive the second motion component to move up and down relative to the first motion component, and to drive the third motion component to move up and down relative to the second motion component;

[0013] The extractor also includes a vacuum module, the third motion component is used to be connected to the pipette, the output end of the vacuum module is connected to the pipette through a pipeline, and the vacuum module is configured to change the pressure in the pipette to enable the pipette to suck and exhale the sample solution.

[0014] In this solution, the above-mentioned structural form is adopted, and the third motion component can drive the pipette to move in three directions, so that the pipette can be flexibly moved to a preset position to absorb the liquid to be processed, with high flexibility. In addition, the up and down movement stroke of the third motion component on which the pipette is installed is the up and down movement stroke of the second motion component relative to the first motion component plus the up and down movement stroke of the third motion component relative to the second motion component, that is, the up and down movement stroke of the third motion component is increased. When the pipette unit is controlled to load and take pipettes of different lengths, even if some pipettes are relatively short, due to the wide up and down displacement range of the third motion component, these shorter pipettes can also be loaded and taken and absorb the liquid to be processed during the downward movement of the third motion component, that is, it can be adapted to pipettes of various lengths and has a wide range of applications.

[0015] Preferably, the workbench is provided with a first accommodating portion, wherein the first accommodating portion is provided with a plurality of first accommodating cavities, and at least one of the first accommodating cavities is used to place an eluent;

[0016] And / or, a pipette recovery portion is provided on the workbench, and the pipette recovery portion is provided with a second accommodating cavity for placing discarded pipettes.

[0017] In this solution, using the aforementioned structure, the sample solution in the pipette is purified by magnetic beads that adsorb biomolecules such as drugs, proteins, enzymes, antibodies, or nucleic acids. After purification, the biomolecules bound to the beads are transferred to an eluent for further purification. This streamlines the purification process and effectively improves purification efficiency. A pipette recovery unit is provided on the workbench to facilitate the recovery of pipettes removed from the pipetting unit.

[0018] Preferably, a refrigeration module is provided below the workbench, and the refrigeration module is placed below the sample placement portion and is used to keep the sample solution in a low temperature environment.

[0019] In this solution, the above-mentioned structural form is adopted, and the refrigeration module is placed below the sample placement portion to refrigerate the sample solution and ensure that the sample solution is processed or stored at an appropriate temperature.

[0020] Preferably, a magnetic mechanism is provided between the refrigeration module and the sample placement portion, the magnetic mechanism being used to attract magnetic beads in the sample solution, and the magnetic mechanism being configured to be able to move up and down relative to the sample placement portion.

[0021] In this solution, the above-mentioned structural form can be used to control the adsorption state of the magnetic beads according to the needs of the experimental process or processing steps, thereby improving the freedom and controllability of the operation.

[0022] Preferably, the magnetic mechanism includes a heat-conducting plate and a magnet, and the magnet is provided on the upper surface of the heat-conducting plate;

[0023] The refrigeration module includes a semiconductor refrigerator, and the refrigeration surface of the semiconductor refrigerator is in contact with the lower surface of the heat conducting plate.

[0024] In this solution, the aforementioned structure is employed. By installing magnets, the magnetic mechanism generates a magnetic field on the heat-conducting plate, thereby attracting and manipulating the magnetic beads in the sample solution. By attaching the cooling surface of the semiconductor refrigerator to the lower surface of the heat-conducting plate, the sample solution can be cooled rapidly and evenly.

[0025] Preferably, the extractor further comprises a radiator, and the radiator is arranged on one side of the heating surface of the semiconductor refrigerator.

[0026] In this solution, the above-mentioned structural form can effectively transfer the heat generated during the heating process to the radiator and accelerate the dissipation of heat.

[0027] Preferably, the extractor further comprises a lifting mechanism, the lifting mechanism comprising a fixing frame and a supporting member, the fixing frame is provided with a guide column, the supporting member is in sliding cooperation with the guide column, and the magnetic mechanism is provided on the supporting member;

[0028] The lifting mechanism further comprises a lifting motor and a screw, wherein the lifting motor is in driving connection with the screw, and the support member is provided with a screw sleeve portion which is threadedly connected with the screw;

[0029] The axes of the screw and the guide pillar are parallel and extend along the moving direction of the magnetic mechanism.

[0030] In this solution, the above-mentioned structural form is adopted, and the support member and the magnetic mechanism are lifted and lowered by transmitting the power of the lifting motor to the screw, thereby improving the reliability of the lifting movement of the magnetic mechanism.

[0031] Preferably, the extractor includes a mounting bracket, which includes a first support platform and a second support platform spaced apart in an upper and lower direction, the first support platform and the second support platform are connected by a support rod, the workbench is installed on the first support platform, and the refrigeration module is placed between the first support platform and the second support platform.

[0032] In this solution, the above-mentioned structural form is adopted, and the mounting bracket provides installation space for the workbench and the refrigeration module, effectively improving the rationality of the space layout.

[0033] Preferably, the extractor further comprises an outer shell, wherein the pipetting unit and the workbench are built into the outer shell;

[0034] A sterilization mechanism is installed on the top inner wall of the outer shell; and / or a lighting mechanism is installed on the top inner wall of the outer shell.

[0035] In this solution, the aforementioned structure prevents the pipetting unit and workbench from being contaminated by dust or other contaminants, thereby preventing them from affecting their operation. A sterilization mechanism is mounted on the top inner wall of the outer shell to disinfect the interior of the outer shell. A lighting mechanism is also mounted on the top inner wall of the outer shell to illuminate the pipetting unit and workbench during extraction operations, facilitating operator operation.

[0036] Preferably, the first driving device includes a first driving motor and a first screw rod passing through the first moving bracket, the first screw rod extends along the first direction, a first guide member extending along the first direction is connected between the fixed bracket and the first moving bracket, the first moving bracket is provided with a sliding portion that slides with the first guide member, and the first driving motor is used to drive the first screw rod to rotate to drive the first moving bracket to move along the first direction.

[0037] In this solution, the above-mentioned structural form is adopted, and the first moving bracket is driven by the first driving motor to move along the first direction. The structure is simple and easy to operate.

[0038] Preferably, the second driving device comprises a sliding rail and a sliding seat that are slidably connected, the sliding rail is fixed on the first motion bracket, the sliding rail extends along the second direction, and the sliding seat is fixed on the first motion component;

[0039] The second driving device further includes a first driving assembly for driving the slide to move along the second direction.

[0040] In this solution, the above-mentioned structural form is adopted to realize the movement of the second moving bracket along the second direction through the sliding cooperation between the slide seat and the slide rail, and the structure is reliable.

[0041] Preferably, the first drive assembly includes a second drive motor, a first drive wheel, a first driven wheel and a first conveyor belt, the first drive wheel and the first driven wheel are mounted on the first motion bracket and spaced apart along the second direction, the first drive wheel and the first driven wheel are connected by the first conveyor belt, the first drive wheel is connected by the second drive motor, and the slide is mounted on the first conveyor belt.

[0042] In this solution, the above-mentioned structural form is adopted. Under the action of the second drive motor, the first drive wheel and the first driven wheel rotate along the second direction, and the first conveyor belt is transmitted along the second direction, driving the slide to move along the second direction, so as to realize the second moving bracket moving relative to the first moving bracket along the second direction, thereby improving the reliability of the movement of the second moving bracket.

[0043] Preferably, the third driving device includes a second driving component, a second screw and a connecting seat, a first guide component is provided between the first moving component and the second moving component, a second guide component is provided between the second moving component and the third moving component, the second screw is passed through the connecting seat and the connecting seat is connected to the third moving component, and the second driving component is used to drive the second screw to rotate to drive the second moving component and the third moving component to move up and down relative to the first moving component.

[0044] In this solution, the above-mentioned structural form is adopted, and the second driving assembly drives the second screw to rotate to realize the up and down movement of the second motion assembly and the third motion assembly. The structure is simple and the rationality of the spatial layout is improved.

[0045] Preferably, the second drive assembly includes a third drive motor, a second drive wheel, a second driven wheel and a second conveyor belt, the second drive wheel is arranged on the output shaft of the third drive motor, the second driven wheel is installed on the second screw, and the second drive wheel and the second driven wheel are connected by the second conveyor belt.

[0046] In this solution, the above-mentioned structural form is adopted, and the third drive motor drives the second drive wheel to rotate, thereby driving the second conveyor belt transmission, and further driving the second driven wheel to rotate, so as to realize the rotation of the second screw, and further driving the second motion component to move up and down relative to the first motion component, and the third motion component to move up and down relative to the second motion component. The structure is simple and improves the reliability of the movement of the second motion component and the third motion component.

[0047] Preferably, the first motion component and the second motion component are provided with a first travel switch component, and the first travel switch component is configured to be triggered when the second motion component moves upward and / or downward relative to the first motion component to a preset position, so that the second motion component stops moving;

[0048] And / or, a second travel switch assembly is provided on the second motion component and the third motion component, and the second travel switch assembly is configured to be triggered when the third motion component moves upward and / or downward to a preset position relative to the second motion component, so that the third motion component stops moving.

[0049] In this solution, the above-mentioned structural form is adopted to avoid program setting errors causing the second moving component to move up and down excessively and damage the first moving component, etc., and to avoid program setting errors causing the third moving component to move up and down excessively and damage the second moving component, etc.

[0050] Preferably, a magnetic component mounting plate and a fourth driving device are installed on the third motion assembly, the magnetic component mounting plate is provided with magnetic components, and the fourth driving device is used to drive the magnetic component mounting plate to move along the length direction of the pipette.

[0051] In this solution, the above-mentioned structural form is adopted, and the magnetic component mounting plate moves along the length direction of the pipette, thereby improving the compactness of the pipetting unit.

[0052] Preferably, the fourth driving device includes a fourth driving motor and a third screw, the fourth driving motor is drivingly connected to the third screw, the third screw extends along the length of the pipette and is mounted on the third motion assembly, and the magnetic member mounting plate is provided with a moving portion that is threadably engaged with the third screw;

[0053] The magnetic component mounting plate is provided with a first guide portion, and the third motion assembly is provided with a second guide portion. The first guide portion is configured to be able to slide and cooperate with the second guide portion along the axial direction of the third screw.

[0054] In this solution, the above-mentioned structural form is adopted to realize the axial movement of the magnetic mounting plate along the pipette through the transmission between the fourth drive motor and the third screw. The structure is simple, easy to operate, and effectively improves the reliability of the movement of the magnetic mounting plate.

[0055] Preferably, a third driving wheel is provided on the output shaft of the fourth driving motor, a third driven wheel is provided on the third screw, and the third driving wheel and the third driven wheel are connected via a third conveyor belt.

[0056] In this solution, the above-mentioned structural form is adopted. Under the action of the fourth drive motor, the third drive wheel and the third driven wheel rotate in the same direction, thereby driving the third screw to rotate, so as to realize the linear movement of the magnetic component mounting plate, thereby improving the reliability of the movement of the magnetic component mounting plate.

[0057] Preferably, the pipette has a liquid storage cavity, in which an adsorption member capable of being adsorbed by the magnetic member is provided, and the fourth driving device is used to drive the magnetic member to approach or move away from the liquid storage cavity so that the magnetic member adsorbs the adsorption member or the interaction between the magnetic member and the adsorption member is lost.

[0058] In this solution, the above-mentioned structural form is adopted, and the adsorption element is used as an intermediary to improve the adsorption effect of the magnetic element on the magnetic beads, thereby improving the effect of biological molecule separation; and, compared with the magnetic beads being directly adsorbed by the magnetic element, the magnetic beads are adsorbed on the adsorption element and then adsorbed by the magnetic element, which increases the adsorption surface area of ​​the magnetic beads, enhances the adsorption effect, and improves the purification effect of biological molecules.

[0059] Preferably, the adsorbent is an iron bead with an outer diameter of 0.5 mm to 1.5 mm. The iron bead exhibits strong magnetic properties, enabling efficient magnetic adsorption. By controlling the outer diameter range of the iron bead, liquid processing and separation can be tailored to specific needs, improving the adaptability and flexibility of the adsorbent.

[0060] Preferably, the pipette comprises a first tube body and a second tube body integrally connected, the liquid storage cavity being provided in the second tube body, the first tube body having a liquid suction channel communicating with the liquid storage cavity, and the size of the adsorbent being larger than the maximum inner diameter of the communication port between the liquid suction channel and the liquid storage cavity. The adsorbent being larger than the maximum inner diameter of the communication port between the liquid suction channel and the liquid storage cavity can prevent the adsorbent from falling out of the liquid suction channel, ensuring that only liquid can enter and exit the liquid suction channel. For example, if the communication port between the liquid suction channel and the liquid storage cavity is circular, the maximum inner diameter is the maximum inner diameter of the communication port.

[0061] Preferably, an arc-shaped protrusion is provided in the liquid storage chamber, surrounding the connection between the aspiration channel and the liquid storage chamber. The presence of the arc-shaped protrusion increases the uniformity and stability of liquid flow, reduces liquid turbulence and vortexes, and improves separation efficiency. The arc-shaped protrusion also prevents the adsorbent from falling from the liquid storage chamber into the aspiration channel and then detaching from the pipette. Furthermore, an opening is provided at the top of the arc-shaped protrusion, which is connected to the aspiration channel.

[0062] Preferably, a first limiting member is provided at one end of the liquid storage chamber away from the first tube body, and the first limiting member is used to prevent the adsorption member from leaving the liquid storage chamber. A vent is provided on the first limiting member, and the liquid storage chamber is connected to the outside world through the vent. The provision of the first limiting member ensures the stability of the adsorption member in the liquid storage chamber, and prevents it from being sucked out of the pipette by the pipette. At the same time, the design of the vent realizes ventilation between the liquid storage chamber and the outside world, allowing liquid to pass through and avoiding the generation of a negative pressure effect. The first limiting member can be filter cotton. The first limiting member adopts filter cotton material, which not only realizes the limiting effect on the adsorption member, but also has a filtering function, which can prevent impurities from entering the liquid storage chamber and ensure the purity of the separation.

[0063] Furthermore, the inner diameter of the liquid suction channel gradually increases from the end away from the second tube body to the end close to the second tube body. The gradual increase in the inner diameter of the liquid suction channel, that is, the liquid suction channel is tapered, which helps the smooth flow of liquid, reduces fluid resistance, and improves the efficiency of liquid treatment.

[0064] Furthermore, at the connection between the outer wall of the first tube body and the outer wall of the second tube body, a plurality of support ridges are provided around the circumference of the first tube body. One end of each support ridge is connected to the outer wall of the first tube body, and the other end of each support ridge is connected to the outer bottom surface of the second tube body. As part of the connection between the first and second tube bodies, the support ridges provide additional support for the overall structure of the pipette. This helps to enhance the strength and rigidity of the pipette and reduce the risk of deformation and damage. The design of the support ridges enables the pipette to withstand external pressure and force, improving the durability and reliability of the pipette.

[0065] Preferably, the liquid storage chamber is provided with a second stopper located at the connection between the liquid suction channel and the liquid storage chamber, and the second stopper is provided with a special-shaped through hole that penetrates the liquid suction channel. The special-shaped through hole is used to allow liquid to circulate within the liquid storage chamber and the liquid suction channel, and the through hole is also used to prevent the adsorbent from leaving the liquid storage chamber. Providing the second stopper above the connection between the liquid suction channel and the liquid storage chamber can prevent the adsorbent from leaving the liquid storage chamber, while the special-shaped through hole on the second stopper can ensure that the liquid in the liquid storage chamber can flow into the liquid suction channel.

[0066] Furthermore, the irregularly shaped through hole includes a first through hole and a second through hole circumferentially disposed around the first through hole, the first through hole and the second through hole being connected, and the size of the adsorbent is larger than the inner diameters of the first and second through holes. The size of the adsorbent is larger than the inner diameters of the first and second through holes. Therefore, the irregularly shaped through hole formed by the first and second through holes can prevent the adsorbent from falling into the liquid suction channel while ensuring that liquid can flow between the liquid storage chamber and the liquid suction channel.

[0067] Preferably, the sidewall of the second stopper is concave inwardly toward the central axis of the second stopper to form a groove. The groove and the inner wall of the liquid storage chamber form a third through hole that is connected to the liquid suction channel. The third through holes are distributed along the circumference of the second stopper, and the size of the adsorbent is larger than the inner diameter of the third through holes. The third through holes are arranged circumferentially around the second stopper to prevent the adsorbent from falling into the liquid suction channel while ensuring that liquid can flow between the liquid storage chamber and the liquid suction channel.

[0068] Preferably, a pipette detachment mechanism is also installed on the third motion component, and the pipette detachment mechanism includes a detachment plate. A mounting rod is provided on the third motion component, and the mounting rod is provided with a mounting portion for socketing the pipette. The detachment plate is located above the mounting portion, and the detachment plate is configured to be movable relative to the mounting rod so that the pipette is detached from the mounting rod due to the force of the detachment plate.

[0069] In this solution, the above-mentioned structural form is adopted, and the pipette on the mounting part can be automatically detached by the pipette detaching machine, avoiding the use of manual means to detach the pipette, and can fully realize the automated operation of the pipette unit, thereby increasing the working efficiency of the pipette unit.

[0070] Preferably, the pipette disengagement mechanism also includes a fifth drive motor, a mounting member and a fourth screw, the mounting member is fixed on the third motion assembly, the upper end of the fourth screw is mounted on the mounting member through a bearing and is transmission-connected to the fifth drive motor, the lower end of the fourth screw is penetrated by a connecting member, the connecting member is connected to the disengagement plate, a guide member is provided on the third motion assembly, the connecting member is slidably engaged with the guide member, and the fifth drive motor is used to drive the fourth screw to rotate to drive the connecting member to move along the axial direction of the fourth screw.

[0071] In this solution, the above-mentioned structural form is adopted, and the movement of the disengagement plate is controlled by the transmission between the fifth drive motor and the fourth screw to automatically realize the disengagement of the pipette. The mechanical structure is simplified, safe and reliable, and the linkage effect is correct.

[0072] Preferably, the connecting member includes a connecting plate and a connecting rod, two ends of the connecting rod are fixedly connected to the connecting plate and the detachment plate respectively, and the fourth screw rod is threadedly engaged with the connecting plate.

[0073] In this solution, the above-mentioned structural form is adopted, and the connecting parts are composed of connecting plates and connecting rods that are connected to each other, which facilitates the processing of parts.

[0074] Preferably, a fourth through hole is provided on the separation plate, the lower end of the mounting rod passes through the fourth through hole and is sleeved with the pipette, the mounting rod and the fourth through hole are gap-fitted, the end of the pipette used for connection with the mounting rod is set as the first end, and the inner diameter of the fourth through hole is smaller than the outer diameter of the first end.

[0075] In this solution, the above-mentioned structural form is adopted, and the dimensions of the mounting rod, the fourth through hole and the first end are set in such a way as to ensure that the detachment plate slides smoothly on the mounting rod, and can ensure that the detachment plate drives the pipette to detach from the mounting rod during the movement relative to the mounting rod. The structure is reliable and effectively improves the efficiency of detaching the pipette.

[0076] The positive progress effect of the present invention is:

[0077] The third motion component in the extractor of the present invention can drive the pipette to move in three directions, so that the pipette can be flexibly moved to a preset position to absorb the liquid to be processed, with high flexibility. In addition, the stroke of the third motion component for installing the pipette is the stroke of the second motion component moving up and down relative to the first motion component plus the stroke of the third motion component moving up and down relative to the second motion component, that is, the stroke of the third motion component moving up and down is increased. When the extractor is used to load and take pipettes of different lengths, even if some pipettes are relatively short, due to the wide range of the up and down displacement of the third motion component, these pipettes with relatively short lengths can also be loaded and taken and absorb the liquid to be processed during the downward movement of the third motion component, that is, it can be adapted to pipettes of various lengths and has a wide range of applications. BRIEF DESCRIPTION OF THE DRAWINGS

[0078] Figure 1 is a structural schematic diagram of the extractor of Example 1 of the present invention; Figure 2 is another structural schematic diagram of the extractor of Example 1 of the present invention; Figure 3 is a schematic diagram of the internal structure of the extractor of Example 1 of the present invention; Figure 4 is another schematic diagram of the internal structure of the extractor of Example 1 of the present invention; Figure 5 is a partial schematic diagram of the extractor of Example 1 of the present invention; Figure 6 is a schematic diagram of the installation of the sample placement part of Example 1 of the present invention; Figure 7 is another partial schematic diagram of the extractor of Example 1 of the present invention; Figure 8 is a structural schematic diagram of the pipetting unit of Example 1 of the present invention; Figure 9 is a schematic diagram of the coordination of the fixed bracket and the first moving bracket of Example 1 of the present invention; Figure 10 is a schematic diagram of the coordination of the first moving bracket and the first moving component of Example 1 of the present invention; Figure 11 is a schematic diagram of the coordination of the first moving bracket and the first moving component of Example 1 of the present invention at another angle; Figure 12 is a structural schematic diagram of the second moving bracket of Example 1 of the present invention; Figure 13 is a schematic diagram of the partial structure of the second moving bracket of Example 1 of the present invention; Figure 14 is a schematic diagram of the second moving bracket of Example 1 of the present invention 1 . A schematic diagram of the exploded view of the bracket; Figure 15 is another partial schematic diagram of the second moving bracket of Example 1 of the present invention; Figure 16 is a partial schematic diagram of the pipetting unit of Example 1 of the present invention; Figure 17 is another partial schematic diagram of the pipetting unit of Example 1 of the present invention; Figure 18 is a schematic diagram of the initial state of the second moving bracket of Example 2 of the present invention; Figure 19 is a schematic diagram of the intermediate state of the second moving bracket of Example 2 of the present invention; Figure 20 is a schematic diagram of the final state of the second moving bracket of Example 2 of the present invention; Figure 21 is a structural schematic diagram of the pipetting unit of Example 2 of the present invention; Figure 22 is a partial structural schematic diagram of the pipetting unit of Example 2 of the present invention; Figure 23 is a structural schematic diagram of the pipette in Example 1 of the present invention; Figure 24 is a sectional view of the pipette in Example 1 of the present invention; Figure 25 is an enlarged view of point A in Figure 24 of the present invention; Figure 26 is a structural schematic diagram of the pipette in Example 3 of the present invention; Figure 27 is an internal sectional view of the pipette in Example 3 of the present invention; Figure 28 is another internal sectional view of the pipette in Example 3 of the present invention. DETAILED DESCRIPTION

[0079] Example 1

[0080] Please understand in conjunction with Figures 1 to 17 that an embodiment of the present invention provides an extractor, which includes a pipette unit 1 and a workbench 4. The workbench 4 is provided with a pipette placement portion 41 and a sample placement portion 42. The pipette placement portion 41 is used to place unused pipettes 3, and the sample placement portion 42 is used to place sample solutions to be processed. Among them, the pipetting unit 1 includes a fixed bracket 11, a first moving bracket 12 and a second moving bracket 13. A first driving device 14 is provided between the fixed bracket 11 and the first moving bracket 12. The first driving device 14 is used to drive the first moving bracket 12 to move horizontally in a first direction relative to the fixed bracket 11; a second driving device 16 is provided between the first moving bracket 12 and the second moving bracket 13. The second driving device 16 is used to drive the second moving bracket 13 to move horizontally in a second direction relative to the first moving bracket 12, and the second direction is perpendicular to the first direction; the second moving bracket 13 includes a first moving component 131, a second moving component 132 and a third moving component 133 that are slidably connected in sequence, and the first moving component 131 is connected to the first moving bracket 12; the pipetting unit also includes a third driving device 17. The third driving device 17 is used to drive the second moving component 132 to move up and down relative to the first moving component 131, and to drive the third moving component 133 to move up and down relative to the second moving component 132. The extractor also includes a vacuum module 5. The third motion component 133 is used to connect to the pipette 3. The output end of the vacuum module 5 is connected to the pipette 3 through a pipeline. The vacuum module 5 is configured to change the pressure in the pipette 3 to enable the pipette 3 to suck and discharge the sample solution.

[0081] In this embodiment, the first moving bracket 12 moves horizontally along the first direction through the first driving device 14. During this process, since the second moving bracket 13 is connected to the first moving bracket 12, the third moving component 133 for installing the pipette 3 moves horizontally along the first direction; in the process of the second moving bracket 13 moving horizontally along the second direction through the second driving device 16, the third moving component 133 therein also moves along the second direction. In other words, the third moving component 133 is driven to move horizontally by the first driving device 14 and the second driving device 16 to realize the movement of the third moving component 133 to the top of the pipette placement portion 41; under the action of the third driving device 17, the second moving component 132 can move up and down relative to the first moving component 131, and the third moving component 133 can move up and down relative to the second moving component, so that the third moving component 133 moves downward to socket the pipette 3. After the pipette 3 is installed, the first, second, and third actuators 14, 16, and 17 control the third motion assembly 133 to move above the sample placement portion 42. The third actuator 17 then controls the downward movement of the pipette 3, inserting it into the sample solution. The vacuum module 5 is activated to create a negative pressure within the pipette 3, drawing the sample solution and ultimately extracting the sample solution. This demonstrates that the third motion assembly 133 can drive the pipette 3 in three directions, allowing it to be flexibly moved to a predetermined position to draw the sample solution, providing a high degree of flexibility. On the other hand, the stroke of the third moving component 133 for installing the pipette 3 is the stroke of the second moving component 132 moving up and down relative to the first moving component 131 plus the stroke of the third moving component 133 moving up and down relative to the second moving component 132, that is, the stroke of the third moving component 133 moving up and down is increased. When the pipette unit 1 in this embodiment is used to load and unload pipettes of different lengths, even if some pipettes 3 are relatively short, due to the wide range of the up and down displacement of the third moving component 133, during the downward movement of the third moving component 133, these relatively short pipettes 3 can also be loaded and taken in and the liquid to be processed can be absorbed, that is, it can be adapted to pipettes 3 of various lengths and has a wide range of applications. In addition, due to the wide range of the up and down displacement of the third moving component 133, the pipette unit 1 in this embodiment can be adapted to extractors of various heights, that is, it can adapt to a wide range of types of extractors.

[0082] Specifically, the length direction of the fixed bracket 11 is recorded as the first direction, also recorded as the X-axis direction; the width direction of the fixed bracket 11 is recorded as the second direction, also recorded as the Y-axis direction; the height direction of the fixed bracket 11 is recorded as the up and down direction, also recorded as the Z-axis direction, that is, the third motion component 133 can move to a preset position in three dimensions along the X-axis, Y-axis and Z-axis.

[0083] In this embodiment, the vacuum module 5 extracts gas from the pipette 3 through the pipeline, thereby controlling the pipette 3 to absorb the sample solution; and pressurizes the interior of the pipette 3 through the pipeline, thereby controlling the pipette 3 to discharge liquid.

[0084] In some embodiments, as shown in Figures 1 and 3, a first receiving portion 43 is provided on the workbench 4, and a plurality of first receiving cavities 431 are provided in the first receiving portion 43, and at least one first receiving cavity 431 is used to place an eluent. The sample solution in the pipette 3 is purified by adsorbing biological molecules such as drugs, proteins, enzymes, antibodies or nucleic acids through magnetic beads. After purification, the biological molecules bound to the magnetic beads are transferred to the eluent so that the next step of purification can be performed. The purification process is smooth and the purification efficiency is effectively improved. Among them, the plurality of first receiving cavities 431 may not all be used to fill the eluent. Some of the first receiving cavities 431 are set as cavities, and the vacuum module 5 controls the pipette 3 to spit the waste liquid (without magnetic beads, i.e., without the biological molecules extracted from the magnetic beads) into the first receiving cavity 431 as a cavity. A pipette recovery portion 44 is provided on the workbench 4. The pipette recovery portion 44 is provided with a second receiving cavity 441 for placing discarded pipettes 3, which is convenient for recycling the pipettes 3 replaced on the pipetting unit 1.

[0085] In this embodiment, as shown in Figures 5 to 7 , a refrigeration module 6 is provided below the workbench 4. This refrigeration module 6 is positioned below the sample placement portion 42 and is used to maintain a low-temperature environment for the sample solution. The refrigeration module 6 is positioned below the sample placement portion 42 to cool the sample solution, ensuring that the sample solution is processed or stored at an appropriate temperature.

[0086] 5 and 6 , an insulation box body 421 is provided around the sample placement portion 42 on the workbench 4, and an insulation box cover 422 is provided on the top of the insulation box body 421. The insulation box body 421 and the insulation box cover 422 together constitute an insulation box for keeping the sample solution warm.

[0087] In this embodiment, as shown in Figures 5 to 7, a magnetic mechanism 7 is provided between the refrigeration module 6 and the sample placement portion 42. The magnetic mechanism 7 is used to attract the magnetic beads in the sample solution, and the magnetic mechanism 7 is configured to be able to move up and down relative to the sample placement portion 42. When it is necessary to adsorb the magnetic beads in the sample solution, the magnetic mechanism 7 can move up and down relative to the sample placement portion 42, that is, move to the bottom of the sample placement portion 42 and fit with the bottom surface of the sample placement portion 42. This adsorption operation can conveniently achieve the separation, aggregation or other processing requirements of the magnetic beads. When it is not necessary to adsorb the magnetic beads, the magnetic mechanism 7 can move to a position away from the sample placement portion 42, that is, move downward, so that the magnetic beads are no longer affected by the magnetic force, thereby stopping adsorption. Such operational flexibility makes it possible to control the adsorption state of the magnetic beads according to the needs of the experimental process or processing steps, thereby improving the freedom and controllability of the operation. Among them, the magnetic beads in the sample solution are nanomagnetic beads or micron magnetic beads.

[0088] In this embodiment, as shown in Figure 7, the magnetic mechanism 7 includes a heat-conducting plate 71 and a magnet 72, with the magnet 72 positioned on the upper surface of the heat-conducting plate 71. The cooling module 6 includes a semiconductor refrigerator, the cooling surface of which is bonded to the lower surface of the heat-conducting plate 71. By providing magnet 72, the magnetic mechanism 7 generates a magnetic field on the heat-conducting plate 71, thereby attracting and manipulating the magnetic beads in the sample solution. By bonding the cooling surface of the semiconductor refrigerator to the lower surface of the heat-conducting plate 71, the sample solution can be cooled rapidly and evenly.

[0089] The heat conducting plate 71 of this embodiment is a copper plate. The thermal conductivity of the copper plate helps maintain a stable temperature of the magnetic mechanism 7 and the sample solution, improving the thermal balance of the device. In other embodiments, the heat conducting plate 71 can be made of other materials with good thermal conductivity, such as aluminum.

[0090] Specifically, there are two semiconductor refrigerators, which are placed in parallel and adjacent to each other.

[0091] In this embodiment, as shown in FIG7 , the extractor further includes a radiator 81 , which is disposed on one side of the heating surface of the semiconductor refrigerator. The heat generated during the heating process can be effectively transferred to the radiator 81 and the heat dissipation can be accelerated.

[0092] In this embodiment, the radiator 81 is a fin structure. In other embodiments, the radiator 81 can also be other structures, such as a liquid cooling radiator, a pipe radiator, etc.

[0093] The extractor also includes a fan 82, which is located on the side of the radiator 81 away from the semiconductor refrigerator. The air outlet of fan 82 faces the fins of radiator 81. By providing fan 82 and installing it on the side of the radiator 81 away from the semiconductor refrigerator, the heat dissipation effect can be further improved. The airflow generated by fan 82 accelerates the exchange of heat with the surrounding air, helping to quickly remove heat and provide new cold air to the radiator 81, improving overall heat dissipation efficiency.

[0094] In this embodiment, as shown in FIG7 , the extractor further includes a lifting mechanism 9 , which includes a fixed frame 91 and a support member 92 . The fixed frame 91 is provided with a guide post 93 , and the support member 92 slides in cooperation with the guide post 93 . The magnetic mechanism 7 is disposed on the support member 92 . The lifting mechanism 9 also includes a lifting motor 94 and a screw 95 , which are in transmission connection with the lifting motor 94 . The support member 92 is provided with a screw sleeve portion 921 threadedly connected to the screw 95 . The axes of the screw 95 and the guide post 93 are parallel and extend along the direction of movement of the magnetic mechanism 7 . The lifting motor 94 drives the screw 95 to rotate. Under the guidance of the guide post 93 , the screw sleeve portion 921 drives the support member 92 along the axial direction of the guide post 93 , thereby achieving the lifting and lowering movement of the magnetic mechanism 7 . By transmitting the power of the lifting motor 94 to the screw 95 , the support member 92 and the magnetic mechanism 7 are lifted and lowered, thereby improving the reliability of the lifting and lowering movement of the magnetic mechanism 7 . Specifically, the screw 95 and the guide post 93 extend up and down.

[0095] Specifically, the fixed frame 91 includes an upper frame and a lower frame, which are fixedly connected by a plurality of guide posts 93. A fifth drive wheel 96 is provided on the output shaft of the lifting motor 94, and a fifth driven wheel 97 is provided on the screw 95. The lifting motor 94 drives the fifth drive wheel 96, which is driven by the fifth conveyor belt to rotate the fifth driven wheel 97, thereby driving the screw 95 to rotate, thereby achieving the lifting and lowering of the support member 92.

[0096] In this embodiment, as shown in Figures 3 to 6, the extractor includes a mounting bracket 10, which includes a first support platform 101 and a second support platform 102 spaced apart from each other. The first support platform 101 and the second support platform 102 are connected by a support rod 103. The workbench 4 is mounted on the first support platform 101, and the refrigeration module 6 is placed between the first support platform 101 and the second support platform 102. The mounting bracket 10 provides installation space for the workbench 4 and the refrigeration module 6, effectively improving the rationality of the spatial layout.

[0097] In this embodiment, a side bracket 104 is further provided on the first supporting platform 101 , and the pipetting unit 1 is mounted on the side bracket 104 .

[0098] In some embodiments, as shown in Figures 1 and 2, the extractor further includes an outer shell 105, and the pipetting unit 1 and the workbench 4 are built into the outer shell 105 to prevent the pipetting unit 1 and the workbench 4 from being contaminated with dust or other pollutants, thereby avoiding affecting the operation of the pipetting unit 1 and the workbench 4. A sterilization mechanism 106 is installed on the top inner wall of the outer shell 105 for disinfecting the internal environment of the outer shell 105. Specifically, the sterilization mechanism 106 can adopt an ultraviolet sterilization lamp. A lighting mechanism 107 is installed on the top inner wall of the outer shell 105 for lighting when the pipetting unit 1 and the workbench 4 cooperate to perform the extraction operation, so as to facilitate the operation of the staff.

[0099] In this embodiment, as shown in Figures 8 and 9, the first drive device 14 includes a first drive motor 141 and a first screw 142 that passes through the first motion bracket 12. The first screw 142 extends along the first direction. A first guide member 15 that extends along the first direction is connected between the fixed bracket 11 and the first motion bracket 12. The first motion bracket 12 is provided with a sliding portion 121 that slidably cooperates with the first guide member 15. The first drive motor 141 is used to drive the first screw 142 to rotate to drive the first motion bracket 12 to move along the first direction. The first drive motor 141 drives the first screw 142 to rotate. When the first guide member 15 and the sliding portion 15 are limited in the sliding cooperation along the first direction, the first motion bracket 12 mounted on the first screw 142 moves along the first direction. The first motion bracket 12 is driven by the first drive motor 141 to move along the first direction. The structure is simple and easy to operate.

[0100] Specifically, as shown in Figure 9, the fixed bracket 11 is provided with a guide rail as the first guide member 15. The first screw 142 is disposed through the sliding portion 121 and is threadedly engaged with the sliding portion 121. During rotation of the first screw 142, the sliding portion 121 slides along the guide rail in a first direction. The first drive motor 141 is preferably a stepper motor. Of course, in other examples, as an alternative, the first movable bracket 12 can output motion in the first direction via other linear motion mechanisms, such as those based on pneumatic cylinders, hydraulic cylinders, electric cylinders, or cam mechanisms.

[0101] In this embodiment, the fixed bracket 11 includes two columns 111 spaced apart along a first direction. A second guide member 112 extending along the first direction is disposed between the two columns 111. The upper end of the first movable bracket 12 is sleeved within the second guide member 112, and the lower end of the first movable bracket 12 is sleeved within the first screw 142. The second guide member 112 further guides the movement of the first movable bracket 12, thereby improving the reliability of the movement of the pipetting unit 1. Furthermore, the upper and lower ends of the first movable bracket 12 are connected to the fixed bracket 11, enhancing the stability of the first movable bracket 12 during movement.

[0102] Specifically, as shown in FIG9 , the fixed bracket 11 includes a first bracket and a second bracket spaced apart from each other. The first bracket is located at the top and includes a first fixed plate. The first fixed plate has downwardly extending columns 111 at both ends. A second guide member 112 is connected to the two columns 111 at both ends. A guide track is provided on the bottom surface of the first fixed plate. The upper end of the first movable bracket 12 is slidably connected to the guide track. The second guide member 112 can be a flat bar that passes through the upper end of the first movable bracket 12. Alternatively, the second guide member 112 can be a lead screw. A motor is mounted on the column 111. The motor drives the second guide member 112 to rotate, thereby driving the upper end of the first movable bracket 12 to move in the first direction. The second bracket is located at the bottom and includes a second fixed plate. The second fixed plate has upwardly extending end plates at both ends. A first screw rod 142 is connected to the two end plates at both ends. A guide track is provided on the top surface of the second fixed plate. The lower end of the first movable bracket 12 is slidably connected to the guide track.

[0103] More specifically, the first moving bracket 12 includes a first moving part 122 and a second moving part 123 connected to each other, the first moving part 122 extends in the up and down directions, the upper end of the first moving part 122 is sleeved on the second guide member 112, the lower end of the first moving part 123 is sleeved on the first screw 142, the second moving part 123 extends along the second direction, and the end of the second moving part 123 is connected to the side of the first moving part 123.

[0104] In this embodiment, as shown in Figures 10 and 11, the second drive device 16 includes a sliding rail 161 and a sliding seat 162 that are slidably connected. The slide rail 161 is fixed to the first motion bracket 12 and extends in the second direction. The slide seat 162 is fixed to the first motion assembly 131. The second drive device 16 also includes a first drive assembly 163 that drives the slide seat 162 in the second direction. The first drive assembly 163 drives the slide seat 162 to move relative to the slide rail 161 in the second direction, thereby achieving movement of the second motion bracket 13 in the second direction relative to the first motion bracket 12. The movement of the second motion bracket 13 in the second direction is achieved through the sliding cooperation between the slide seat 162 and the slide rail 161, resulting in a reliable structure.

[0105] In this embodiment, the first drive assembly 163 includes a second drive motor 1631, a first drive wheel 1632, a first driven wheel 1633 and a first conveyor belt 1634. The first drive wheel 1632 and the first driven wheel 1633 are installed on the first moving bracket 12 and are spaced apart along the second direction. The first drive wheel 1632 and the first driven wheel 1633 are connected by the first conveyor belt 1634. The first drive wheel 1632 is connected by the second drive motor 1631, and the slide 162 is installed on the first conveyor belt 1634. The second drive motor 1631 drives the first drive wheel 1632 to rotate, thereby driving the first conveyor belt 1634 to transmit, and further driving the first driven wheel 1633 to rotate. That is, under the action of the second drive motor 1631, the first drive wheel 1632 and the first driven wheel 1633 rotate in the second direction, and the first conveyor belt 1634 transmits in the second direction, driving the slide 162 to move in the second direction, so as to achieve the second motion bracket 13 to move in the second direction relative to the first motion bracket 12, thereby improving the reliability of the movement of the second motion bracket 13. Among them, the second drive motor 1631 is preferably a stepper motor. Of course, in other examples, as an alternative means, the first motion component 131 can output motion in the second direction through other linear motion mechanisms, such as a linear motion mechanism based on a pneumatic cylinder, a hydraulic cylinder, an electric cylinder or a cam mechanism.

[0106] Specifically, the slide 162 is mounted on the slide rail 161 and is slidably connected to the upper and lower ends of the slide rail 161. Preferably, the first driving wheel 1632 is engaged with the first conveyor belt 1634, and the first driven wheel 1633 is engaged with the first conveyor belt 1634.

[0107] In this embodiment, as shown in Figures 12 and 13, the third drive device 17 includes a second drive component 171, a second screw 172 and a connecting seat 173. A first guide component 18 is provided between the first motion component 131 and the second motion component 132, and a second guide component 19 is provided between the second motion component 132 and the third motion component 133. The second screw 172 is passed through the connecting seat 173 and the connecting seat 173 is connected to the third drive component 133. The second drive component 171 is used to drive the second screw 172 to rotate to drive the second motion component 132 and the third motion component 133 to move up and down relative to the first motion component 131. Second drive assembly 171 drives second screw 172 to rotate, and second screw 172 engages with connecting base 173 to achieve the lifting and lowering of connecting base 173. First guide assembly 18 and second guide assembly 19 extend vertically. Under the limit of first guide assembly 18, second motion assembly 132, which is mounted on second screw 172, moves up and down; under the limit of second guide assembly 19, third motion assembly 133, which is mounted on second screw 172, moves up and down. The vertical movement of second and third motion assemblies 132, 133 is achieved by second drive assembly 171 driving the rotation of second screw 172, resulting in a simple structure and improved spatial layout rationality.

[0108] In other embodiments, the third driving device 17 includes a first driving mechanism and a second driving mechanism, the first driving mechanism is used to drive the second motion component 132 to move up and down relative to the first motion component 131, and the second driving mechanism is used to drive the third motion component 133 to move up and down relative to the second motion component 132.

[0109] As shown in Figure 12, the second drive assembly 171 includes a third drive motor 1711, a second drive wheel 1712, a second driven wheel 1713, and a second conveyor belt (not shown in the figure). The second drive wheel 1712 is arranged on the output shaft of the third drive motor 1711, and the second driven wheel 1713 is mounted on the second screw 172. The second drive wheel 1712 and the second driven wheel 1713 are connected by the second conveyor belt transmission. The third drive motor 1711 drives the second drive wheel 1712 to rotate, thereby driving the second conveyor belt transmission, further driving the second driven wheel 1713 to rotate, thereby rotating the second screw 172, and further driving the second motion assembly 132 to move up and down relative to the first motion assembly 131, and the third motion assembly 133 to move up and down relative to the second motion assembly 132. The structure is simple and improves the reliability of the movement of the second motion assembly 132 and the third motion assembly 133. Among them, the third drive motor 1711 is preferably a stepper motor. Of course, in other examples, as an alternative, the second motion assembly 132 and the third motion assembly 133 may output up and down motions through other linear motion mechanisms, such as linear motion mechanisms based on air cylinders, hydraulic cylinders, electric cylinders, or cam mechanisms.

[0110] Specifically, a protruding plate 174 is installed on the side wall of the first motion component 131 , and the third driving motor 1711 and the second driving wheel 1712 are respectively installed above and below the protruding plate 174 .

[0111] In some embodiments, a first travel switch assembly 20 is provided on the first and second movement assemblies 131 and 132. The first travel switch assembly 20 is configured to be triggered when the second movement assembly 132 moves upward and / or downward relative to the first movement assembly 131 to a preset position, thereby stopping the movement of the second movement assembly 132. The first travel switch assembly 20 limits the maximum upward movement range of the second movement assembly 132 relative to the first movement assembly 131; or limits the maximum downward movement range of the second movement assembly 132 relative to the first movement assembly 131; or limits both the maximum upward movement range and the maximum downward movement range of the second movement assembly 132 relative to the first movement assembly 131. This prevents programming errors from causing the second movement assembly 132 to move excessively upward or downward, thereby damaging the first movement assembly 131. The first travel switch assembly 20 can utilize an existing travel switch, which is well known in the art and will not be described in detail here.

[0112] In some embodiments, a second travel switch assembly (not shown) is provided on the second motion assembly 132 and the third motion assembly 133. The second travel switch assembly is configured to be triggered when the third motion assembly 133 moves upward and / or downward relative to the second motion assembly 132 to a preset position, thereby stopping the movement of the third motion assembly 133. The second travel switch assembly limits the maximum upward movement of the third motion assembly 133 relative to the second motion assembly 132; or limits the maximum downward movement of the third motion assembly 133 relative to the second motion assembly 132; or limits both the maximum upward movement and the maximum downward movement of the third motion assembly 133 relative to the second motion assembly 132. This prevents programming errors from causing the third motion assembly 133 to move excessively up or down, thereby damaging the second motion assembly 132. The second travel switch assembly can employ an existing travel switch, which is well known in the art and will not be described in detail here.

[0113] In other embodiments, limit blocks are provided in the first guide assembly 18 and the second guide assembly 19, and the maximum downward movement stroke of the second motion assembly 132 relative to the first motion assembly 131 depends on the position of the limit block in the first guide assembly 18; the maximum downward movement stroke of the third motion assembly 133 relative to the second motion assembly 132 depends on the position of the limit block in the second guide assembly 19.

[0114] Specifically, when the third motion component 133 needs to move downward to load and remove the pipette 3, the third drive motor 1711 drives the second screw 172 to rotate, and the second motion component 132 and the third motion component 133 move downward synchronously, so that the third motion component 133 approaches the pipette 3 and loads and removes the pipette 3; when the mounting rod 22 for mounting the pipette 3 in the third motion component 133 has not yet been able to be sleeved onto the pipette 3, the third motion component 133 continues to move downward under the action of the rotation of the second screw 172.

[0115] In some embodiments, as shown in Figure 14, the first guide assembly 18 adopts a cross ball guide rail, and the first guide assembly 18 includes a first guide rail 181, a second guide rail 182, a cylindrical roller and a roller retainer. The first guide rail 181 is arranged on the first motion assembly 131, and the second guide rail 182 is arranged on the second motion assembly 132. The roller retainer equipped with cylindrical rollers is arranged between the first guide rail 181 and the second guide rail 182. During the up and down movement of the second motion assembly 132 relative to the first motion assembly 131, the cylindrical rollers arranged crosswise with each other reciprocate on the second guide rail 182, which can withstand loads in all directions and achieve high-precision and smooth linear motion.

[0116] As shown in FIG. 15 , the second guide assembly 19 adopts a cross ball guide rail and may have the same structure as the first guide assembly 18 .

[0117] In this embodiment, as shown in Figure 16 , a magnetic mounting plate 24 and a fourth drive device 25 are mounted on the third motion assembly 133. The magnetic mounting plate 24 is provided with a magnetic member 241, and the fourth drive device 25 is used to drive the magnetic mounting plate 24 to move along the length of the pipette 3. The magnetic mounting plate 24 moves along the length of the pipette 3, improving the compactness of the pipetting unit. Specifically, the pipette 3 extends vertically, and thus the magnetic mounting plate 24 is driven up and down by the fourth drive device 25.

[0118] Among them, the pipette 3 adapted to the extractor in this embodiment is provided with an adsorption component (not shown in the figure) that can be adsorbed by the magnetic component 241, and the pipette 3 is provided with a liquid storage cavity for placing the adsorption component. When purification operation is required, the fourth driving device 25 can drive the magnetic component 241 to move in a direction close to the liquid storage cavity so that the magnetic component 241 adsorbs the adsorption component; after purification is completed, the fourth driving device 25 can also drive the magnetic component 241 to move in a direction away from the liquid storage cavity so that the interaction between the magnetic component 241 and the adsorption component is lost. During the biomolecule purification process, the pipette 3 draws a sample solution containing nano- or micro-magnetic beads that bind to drugs, proteins, enzymes, antibodies, or nucleic acids for purification. The sample solution retains specific substances adsorbed on the magnetic beads, thereby achieving separation and purification of various types of biomolecules. The fourth driving device 25 drives the magnetic member 241 toward the liquid reservoir. The magnetic member 241 adsorbs the adsorbent within the liquid reservoir, generating magnetism. Biomolecules such as proteins and nucleic acids in the sample solution adhere to the magnetic beads within the liquid reservoir. Inside the pipette 3, the adsorbent adsorbs and gathers the magnetic beads, which are then adsorbed by the magnetic member 241. This prevents magnetic beads from not being adsorbed by the magnetic member 241 outside the pipette 3 and reducing the separation effect. In other words, the adsorbent acts as an intermediary to enhance the adsorption effect of the magnetic member 241 on the magnetic beads, thereby improving the biomolecule separation effect. Furthermore, compared to magnetic beads being directly adsorbed by the magnetic member 241, the adsorption of the magnetic beads by the adsorbent and then by the magnetic member 241 increases the adsorption surface area of ​​the magnetic beads, enhancing the adsorption effect and improving the biomolecule purification effect. Specifically, the magnetic member 241 is a permanent magnet. Alternatively, the extractor in this embodiment can also be adapted to a pipette 3 without an adsorption member.

[0119] As shown in Figure 23, in this embodiment, the pipette 3 includes a first tube body 310 and a second tube body 320 that are integrally connected. The pipette 3 includes a liquid storage cavity 321, which is arranged in the second tube body 320. The first tube body 310 has a liquid suction channel 311 connected to the liquid storage cavity 321, and the liquid storage cavity 321 is provided with an adsorption component 330 that can be adsorbed by a magnet, and the size of the adsorption component 330 is larger than the inner diameter of the connecting port between the liquid suction channel 311 and the liquid storage cavity 321.

[0120] In this embodiment, the connection between the liquid suction channel 311 and the liquid storage chamber 321 is circular; the adsorbent 330 is an iron bead, and the outer diameter of the iron bead is any size between 0.5mm-1.5mm, and the specific size can be determined according to actual needs. Of course, the size of the iron bead can also be other suitable sizes. There are multiple numbers of iron beads. By setting the iron beads, when a magnet is placed outside the pipette, the iron beads are given magnetic force to attract the biological magnetic beads in the sample solution, which can enhance the suction force of the magnet and adsorb the nanomagnetic beads as much as possible. In other embodiments, the adsorbent can be made of other materials that can be attracted by magnets; or, the connection between the liquid suction channel 311 and the liquid storage chamber 321 is a non-circular structure. It should be noted that the number of iron beads can be selected as needed. The volume of the liquid storage chamber 321 of the pipette 3 is preferably selected between 20uL-2mL, and pipettes of other volumes can also be selected as needed.

[0121] A first stopper 322 is provided at one end of the liquid storage chamber 321 away from the first tube body 310. The first stopper 322 is used to prevent the iron beads from leaving the liquid storage chamber 321. The first stopper 322 is provided with an air vent, and the liquid storage chamber 321 is connected to the outside world through the air vent. In this embodiment, the first stopper 322 is a filter cotton. By providing the filter cotton, the iron beads can be prevented from being sucked out of the pipette 3 along with the sample solution. At the same time, since the filter cotton has a through hole, liquid can be allowed to flow through, which has the effect of separating the iron beads from the liquid and limiting the position. In other embodiments, the first stopper 322 can be a filter screen, wherein the pore size of the filter screen is smaller than the outer diameter of the iron beads.

[0122] As shown in FIG. 24 and FIG. 25 , in this embodiment, the liquid suction channel 311 is arranged to have equal diameters, and the inner diameter of the liquid suction channel 311 is equal to the diameter of the communication port between the liquid suction channel 311 and the liquid storage chamber 321 .

[0123] The communication port between the liquid suction channel 311 and the liquid storage cavity 321 is located at the axis of the inner bottom surface of the second tube 320. In this embodiment, the minimum inner diameter of the liquid storage cavity 321 is larger than the inner diameter of the liquid suction channel 11.

[0124] An arc-shaped protrusion 323 is provided within the liquid storage chamber 321, surrounding the connection between the aspiration channel 311 and the liquid storage chamber 321. The arc-shaped protrusion 323 increases the uniformity and stability of liquid flow, reduces turbulence and vortices, and improves separation efficiency. It also prevents the adsorbent 330 from falling from the liquid storage chamber 321 into the aspiration channel 311 and then detaching from the pipette 3. The top of the arc-shaped protrusion 323 is provided with an opening that communicates with the aspiration channel 11.

[0125] In this embodiment, at the connection between the outer wall of the first tube body 310 and the outer bottom surface of the second tube body 320, several support ridges 312 are provided around the circumference of the first tube body 310. One end of the support ridge 312 is connected to the outer wall of the first tube body 310, and the other end of the support ridge 312 is connected to the outer bottom surface of the second tube body 320.

[0126] In this embodiment, the support ridge 312, as part of the connection between the first tube 310 and the second tube 320, provides additional support for the overall structure of the pipette 3. This helps to enhance the strength and rigidity of the pipette 3, reducing the risk of deformation and damage. The design of the support ridge 312 enables the pipette to withstand external pressure and forces, thereby improving the durability and reliability of the pipette 3.

[0127] The pipette 3 of this embodiment is manufactured by injection molding, which has the advantages of low production cost and high production efficiency, and is suitable for large-scale production and wide application.

[0128] The pipette 3 provided in this embodiment is provided with an adsorption member 330 that can be adsorbed by a magnet. When the magnet approaches the pipette 3, the adsorption member 330 is endowed with magnetic force and can indirectly adsorb magnetic beads. Compared with the traditional method of adsorbing magnetic beads on the side wall of the pipette 3, the indirect absorption of magnetic beads by the adsorption member 330 increases the adsorption area, can adsorb more magnetic beads, and enables the magnetic beads in the pipette 3 to be adsorbed as much as possible, thereby enhancing the adsorption effect of the magnet. This allows the nanomagnetic beads in the liquid sample to be fully adsorbed and adsorbed onto the magnet more quickly, achieving the effect of rapid separation and purification. Magnetic adsorption technology makes the separation and purification of liquid samples faster, reducing the centrifugation and other operational steps required in traditional methods. This improves the efficiency of liquid processing, and because the adsorption member can more effectively adsorb magnetic beads, the separation effect is also improved. In this embodiment, the fourth drive device 25 includes a fourth drive motor 251 and a third screw 252. The fourth drive motor 251 is in driving connection with the third screw 252. The third screw 252 extends along the length of the pipette 3 and is mounted on the third motion assembly 133. The magnetic mounting plate 24 is provided with a moving portion 242 that is threadedly engaged with the third screw 252. The magnetic mounting plate 24 is provided with a first guide portion 243, and the third motion assembly 133 is provided with a second guide portion 21. The first guide portion 243 is configured to slideably engage with the second guide portion 21 along the axial direction of the third screw 252. The fourth drive device 25 drives the third screw 252 to rotate. With the first guide portion 243 and the second guide portion 21 slidingly engaged along the axial direction of the third screw 252, the moving portion 32 mounted on the third screw 252 moves along the axial direction of the third screw 252 (i.e., the axial direction of the pipette 3), thereby causing the magnetic mounting plate 24 to move along the axial direction of the pipette 3. The magnetic component mounting plate 24 is driven by the fourth drive motor 251 and the third screw 252 to move axially along the pipette 3 . This has a simple structure, is easy to operate, and effectively improves the reliability of the movement of the magnetic component mounting plate 24 .

[0129] Specifically, as shown in FIG3 , the magnetic mounting plate 24 includes a first plate-shaped member 244 and a second plate-shaped member 245 connected to each other, wherein the second plate-shaped member 245 is connected to both ends of the first plate-shaped member 244 and extends upward from the end of the first plate-shaped member 244 . The first plate-shaped member 244 extends horizontally, and the first plate-shaped member 244 and the second plate-shaped member 245 are arranged at a 90-degree angle, thereby reducing the height dimension of the magnetic mounting plate 24 and improving the structural compactness. The two second plate-shaped members 245 are respectively located on either side of the third motion component 133 . A protruding block is fixedly provided on one side of the second plate-shaped member 245 near the third motion component 133 as a moving portion 242 . The third screws 252 at both ends of the third motion component 133 are respectively inserted into the two moving portions 242 . The rotation of the two third screws 252 drives the magnetic mounting plate 24 to move, thereby improving the smoothness of the movement of the magnetic mounting plate 24 . A groove is provided on the side of the second plate-like member 245 near the third motion assembly 133 as the first guide portion 243. A protruding block matching the groove is provided on the side of the third motion assembly 133 near the second plate-like member 245 as the second guide portion 21 for ease of processing. A through hole is provided in the first plate-like member 244, through which the pipette 3 is inserted. A magnetic member 241 is provided on the side of the first plate-like member 244, located on the side of the pipette 3.

[0130] In this embodiment, a third drive wheel 253 is provided on the output shaft of the fourth drive motor 251, and a third driven wheel 254 is provided on the third screw 252. The third drive wheel 253 and the third driven wheel 254 are connected by a third conveyor belt (not shown in the figure). The fourth drive motor 251 drives the third drive wheel 253 to rotate, thereby driving the third conveyor belt to transmit, and further driving the third driven wheel 254 to rotate. That is, under the action of the fourth drive motor 251, the third drive wheel 253 and the third driven wheel 254 rotate in the same direction, thereby driving the third screw 252 to rotate, thereby achieving linear movement of the magnetic component mounting plate 24, thereby improving the reliability of the movement of the magnetic component mounting plate 24. Preferably, the third drive wheel 253 is engaged with the first conveyor belt, and the third driven wheel 254 is engaged with the third conveyor belt, thereby achieving a good transmission effect.

[0131] Specifically, the third motion assembly 133 is provided with a first motor mounting plate, located in the middle of the third motion assembly 133, for mounting the fourth drive motor 251. Mounting seats are provided at both ends of the third motion assembly 133, through which a third screw 252 is inserted, and a third screw 252 is mounted at the upper end of the third screw 252. More specifically, with the third screw 252 provided at both ends of the third motion assembly 133, the third conveyor belt is mounted over the third drive wheel 253 and the two third driven wheels 254, so that the third drive wheel 253 and the two third driven wheels 254 rotate in the same direction.

[0132] Preferably, the third driving wheel 253 and the third driven wheel 254 are arranged at the same horizontal height to improve the installation stability of the third conveyor belt and prevent the first conveyor belt from being separated from the third driving wheel 253 and the third driven wheel 254.

[0133] In this embodiment, as shown in Figures 2 and 3 , there are multiple pipettes 3 , spaced horizontally apart. The pipette movement mechanism 1 simultaneously drives the loading and unloading of multiple pipettes 3 or simultaneously causes multiple pipettes 3 to aspirate sample solution, thereby improving the efficiency of the pipetting unit. Specifically, a group of pipettes 3 contains eight pipettes 3 .

[0134] Preferably, the magnetic member 241 extends along the arrangement direction of the pipettes 3, so that the adsorbents in multiple pipettes 3 are adsorbed to the same degree by the magnetic member 241, and the purification operations in a row of pipettes 3 can be performed simultaneously, thereby improving the extraction efficiency of biomolecules.

[0135] As shown in FIG17 , the third motion assembly 133 is also equipped with a pipette detachment mechanism 26. The pipette detachment mechanism 26 includes a detachment plate 261. The third motion assembly 133 is provided with a mounting rod 22, which is provided with a mounting portion 221 for receiving the pipette 3. The detachment plate 261 is located above the mounting portion 221 and is configured to move relative to the mounting rod 22, so that the pipette 3 is detached from the mounting rod 22 by the force of the detachment plate 261. The pipette 3 has a corresponding socket hole corresponding to the mounting portion 221. The pipette 3 and the mounting portion 221 can be connected and fixed by external force, and can be separated from each other by the force of the detachment plate 261 during movement. The pipette detachment mechanism 26 can automatically detach the pipette 3 from the mounting portion 221 by the pipette detachment mechanism 26, eliminating the need for manual detachment of the pipette 3. This fully automates the operation of the pipette unit and increases the efficiency of the pipette unit.

[0136] In this embodiment, the pipette disengagement mechanism 26 also includes a fifth drive motor 262, a mounting member 263 and a fourth screw 264. The mounting member 263 is fixed on the third motion component 133. The upper end of the fourth screw 264 is mounted on the mounting member 263 through a bearing and is transmission-connected to the fifth drive motor 262. The lower end of the fourth screw 264 is penetrated by a connecting member 265, which is connected to the disengagement plate 261. The third motion component 133 is provided with a guide member 23, and the connecting member 265 is slidably fitted with the guide member 23. The fifth drive motor 262 is used to drive the fourth screw 264 to rotate to drive the connecting member 265 to move along the axial direction of the fourth screw 264. The fourth screw 264 is fixed to the third motion assembly 133 via a mounting member 263. The fifth drive motor 262 drives the fourth screw 264 to rotate. Under the limited position of the sliding fit between the connecting member 265 and the guide member 23, the connecting member 265, which is sleeved on the fourth screw 264, moves axially along the fourth screw 264. This in turn drives the detachment plate 261 connected to the connecting member 265 to move axially along the fourth screw 264, so that the pipette 3 is detached from the mounting rod 22 due to the force of the detachment plate 261. The transmission between the fifth drive motor 262 and the fourth screw 264 controls the movement of the detachment plate 261 to automatically detach the pipette 3, simplifying the mechanical structure, ensuring safety and reliability, and ensuring accurate linkage. The fifth drive motor 262 is preferably a stepper motor.

[0137] In this embodiment, the connector 265 includes a connecting plate 2651 and a connecting rod 2652. The ends of the connecting rod 2652 are fixedly connected to the connecting plate 2651 and the release plate 261, respectively. The fourth screw 264 is threadedly engaged with the connecting plate 2651. In other words, the fifth drive motor 262 drives the fourth screw 264 to rotate, thereby driving the connecting plate 2651, which is mounted on the fourth screw 264, to move axially along the fourth screw 264, thereby sequentially moving the connecting rod 2652 and the release plate 261. The connector 265 is composed of the interconnected connecting plate 2651 and connecting rod 2652, which facilitates the processing of the components.

[0138] Specifically, as shown in FIG17 , the pipette detaching machine 26 further includes a fourth drive wheel 266, a fourth driven wheel 267, and a fourth conveyor belt (not shown). The fourth drive wheel 266 is disposed on the output shaft of the fifth drive motor 262, and the fourth driven wheel 267 is mounted on the fourth screw 264. The fourth drive wheel 266 and the fourth driven wheel 267 are in transmission connection. The fifth drive motor 262 drives the fourth drive wheel 266 to rotate, thereby driving the fourth conveyor belt to further rotate the fourth driven wheel 267, thereby driving the fourth screw 264 to rotate, thereby enabling the connecting member 265 to move axially along the fourth screw 264.

[0139] More specifically, a guide seat is fixedly provided on the third motion component 133 to serve as a guide member 23, and a mounting hole is provided in the middle of the guide member 23 for installing the mounting rod 22. Please refer to Figures 1 and 4 for understanding. The mounting rod 22 and the pipette 3 mounted thereon extend up and down, and the axial direction of the mounting hole is vertically set; guide holes are provided at both end portions of the guide member 23, and the axial direction of the guide hole extends along the up and down direction. The connecting rod 2652 extending up and down is passed through the guide member 23 and slides in the guide hole, so that the connecting rod 2652 is limited by the guide hole during movement and moves along the extension direction of the fourth screw 264. The mounting piece 263 is a strip-shaped piece, and the fourth screw 264 is installed in the middle of the mounting piece 263 through a bearing. A connecting rod 2652 is respectively passed through both sides of the mounting piece 263, further providing guidance for the movement direction of the connecting rod 2652; accordingly, a fourth screw 264 is passed through the middle of the connecting plate 2651, and a connecting rod 2652 is respectively passed through and fixed at both ends of the connecting plate 2651. The two ends of the detachment plate 261 are respectively connected to the lower end of the connecting rod 2652. The movement of the detachment plate 261 is driven by the two connecting rods 2652, thereby improving the smoothness of the movement of the detachment plate 261.

[0140] In this embodiment, the detachment plate 261 is provided with a fourth through-hole. The lower end of the mounting rod 22 passes through the fourth through-hole and is sleeved onto the pipette 3. The mounting rod 22 and the fourth through-hole are loosely fitted. The end of the pipette 3 intended for connection to the mounting rod 22 is the first end, and the inner diameter of the fourth through-hole is smaller than the outer diameter of the first end. The dimensions of the mounting rod 22, the fourth through-hole, and the first end are configured to ensure smooth sliding of the detachment plate 261 on the mounting rod 22 and to drive the pipette 3 off the mounting rod 22 as the detachment plate 261 moves relative to the mounting rod 22. This provides a reliable structure and effectively improves the efficiency of detaching the pipette 3.

[0141] Example 2

[0142] Please refer to Figures 18 to 22 at the same time. Example 2 also provides an extraction device, which differs from the solution in Example 1 in that:

[0143] The third drive motor 1711 and the second drive wheel 1712 are directly mounted on the upper plate of the first motion assembly 131. In the initial state, as shown in FIG18 , the second motion assembly 132 and the third motion assembly 133 are located at the initial positions; as shown in FIG19 , the third drive motor 1711 drives the second screw 172 to rotate, thereby driving the third motion assembly 133 to move downward, so that the second motion assembly 132 and the third motion assembly 133 descend simultaneously, the second motion assembly 132 descends relative to the first motion assembly 131, and the third motion assembly 133 can also descend relative to the second motion assembly 132; as shown in FIG20 , the third drive motor 1711 continues to drive the second screw 172 to rotate, and the second motion assembly 132 continues to descend relative to the first motion assembly 131 until the second motion assembly 132 reaches its maximum travel, and the third motion assembly 133 continues to descend relative to the second motion assembly 132 until the third motion assembly 133 reaches its maximum travel.

[0144] As shown in FIG21 , the fifth drive motor 262 is directly mounted on the mounting member 263. The output end of the fifth drive motor 262 is directly connected to the fourth screw 264 to drive the fourth screw 264 to rotate. Under the limited position of the sliding fit between the connecting member 265 and the guide member 23, the connecting member 265, which is sleeved on the fourth screw 2644, moves axially along the fourth screw 2644, thereby driving the detachment plate 261 connected to the connecting member 265 to move axially along the fourth screw 2644, so that the pipette 3 is detached from the mounting rod 22 due to the force of the detachment plate 261. Specifically, the connecting member 265 includes a connecting plate 2651 and a connecting rod 2652. The fifth drive motor 262 drives the fourth screw 2644 to rotate, thereby driving the connecting plate 2651, which is sleeved on the fourth screw 2644, to move axially along the fourth screw 2644, thereby sequentially achieving the movement of the connecting rod 2652 and the detachment plate 261.

[0145] As shown in FIG22 , there are two fourth drive motors 251 , and the output ends of the two fourth drive motors 251 are directly connected to the third screws 252 to respectively drive the two third screws 252 to rotate, so that the magnetic component mounting plate 244 moves along the axial direction of the pipette 3 .

[0146] Example 3

[0147] Most of the structures of the pipette of this embodiment are the same as those in Example 1, except that, in this embodiment, the inner diameter of the liquid suction channel 311 gradually increases from the end away from the second tube body 320 to the end closer to the second tube body 320. The gradual increase in the inner diameter of the liquid suction channel 311, that is, the tapered shape of the liquid suction channel 311, facilitates the smooth flow of liquid, reduces fluid resistance, and improves the efficiency of liquid suction. Specifically, the minimum inner diameter of the liquid storage chamber 321 of this embodiment is greater than the maximum inner diameter of the liquid suction channel 311. In other embodiments, the minimum inner diameter of the liquid storage chamber 321 may be equal to the maximum inner diameter of the liquid suction channel 311.

[0148] As shown in Figure 26, the first tube body 310 and the second tube body 320 of the pipette of this embodiment are directly connected, and a second limiting member 340 is provided in the liquid storage cavity 321 at the connecting port between the suction channel 311 and the liquid storage cavity 321. The second limiting member 340 is provided with a through hole that passes through the suction channel 311. The through hole is used to allow liquid to circulate in the liquid storage cavity 321 and the suction channel 311. The through hole is also used to prevent the adsorption member 330 from leaving the liquid storage cavity 321.

[0149] The surface of the second stopper 340 away from the communication port between the liquid suction channel 311 and the liquid storage chamber 321 is recessed toward the liquid suction channel 311 to form a concave surface. In other embodiments, it may also be a flat surface or a convex surface.

[0150] Figure 27 shows a case where an adsorption member 330 is provided in the liquid storage chamber 321. The through hole is a special-shaped through hole, which includes a first through hole 341 and a second through hole 342. The first through hole 341 is provided at the axis of the second stopper 340, and the second through holes 342 are provided circumferentially of the first through hole 341. In this embodiment, four second through holes 342 are provided. The first through holes 341 and the second through holes 342 are connected to form a "plum blossom" special-shaped through hole. In this embodiment, there is only one special-shaped through hole, but in other embodiments, multiple special-shaped through holes can be provided. The size of the adsorption member 330 is larger than the inner diameter of the first through hole 341 and the second through hole 342. Therefore, when the pipette is placed vertically, due to the presence of the concave surface, the adsorption component 330 will fall above the first through hole 341 under the action of gravity. The first through hole 341 prevents the adsorption component 330 from falling into the suction channel 311. Due to the presence of the second through hole 342, the adsorption component 330 will not completely block the special-shaped through hole. The liquid can enter and exit the liquid storage chamber 321 and the suction channel 311 through the second through hole 342 circumferentially of the first through hole 341.

[0151] Furthermore, the through hole of the second stopper 340 also includes a third through hole 343, which is provided on its side wall. That is, the side wall of the second stopper 340 is concave inwardly toward its central axis, forming a groove. This groove and the inner wall of the liquid storage chamber 321 form a third through hole 343 that is connected to the liquid suction channel 311. The third through holes 343 are distributed along the circumference of the second stopper 340. The function of the third through hole 343 is the same as that of the above-mentioned special-shaped through hole, wherein the size of the adsorbent 330 is larger than the inner diameter of the third through hole 343. Figure 28 shows a case where multiple adsorbents 330 are provided in the liquid storage chamber 321. With the cooperation of the first through hole 341, the second through hole 342 (shown in Figure 27), and the third through hole 343, the adsorbent 330 will not fall into the liquid suction channel 311, while ensuring that the liquid can circulate within the liquid storage chamber 321 and the liquid suction channel 311. In other embodiments, either the special-shaped through hole or the third through hole 343 can be provided.

[0152] Although the above describes specific embodiments of the present invention, it should be understood by those skilled in the art that these are merely illustrative and that various changes or modifications may be made to these embodiments without departing from the principles and essence of the present invention. Therefore, the scope of protection of the present invention is defined by the appended claims.

Claims

1. An extraction instrument, characterized in that: The extractor comprises a pipetting unit and a workbench, wherein the workbench is provided with a pipette placement portion and a sample placement portion, wherein the pipette placement portion is used to place unused pipettes, and the sample placement portion is used to place sample solutions to be processed; The pipetting unit comprises: Fixed bracket; a first moving bracket, wherein a first driving device is provided between the fixed bracket and the first moving bracket, and the first driving device is used to drive the first moving bracket to move horizontally along a first direction relative to the fixed bracket; a second motion bracket, wherein a second driving device is provided between the first motion bracket and the second motion bracket, and the second driving device is used to drive the second motion bracket to move horizontally relative to the first motion bracket along a second direction, wherein the second direction is perpendicular to the first direction; The second motion bracket includes a first motion component, a second motion component and a third motion component that are slidably connected in sequence, and the first motion component is connected to the first motion bracket; The pipetting unit further includes a third driving device, the third driving device being used to drive the second motion component to move up and down relative to the first motion component, and to drive the third motion component to move up and down relative to the second motion component; The extractor also includes a vacuum module, the third motion component is used to be connected to the pipette, the output end of the vacuum module is connected to the pipette through a pipeline, and the vacuum module is configured to change the pressure in the pipette to enable the pipette to suck and exhale the sample solution.

2. The extractor according to claim 1, wherein The workbench is provided with a first accommodating portion, wherein a plurality of first accommodating cavities are provided in the first accommodating portion, and at least one of the first accommodating cavities is used to place an eluent; And / or, a pipette recovery portion is provided on the workbench, and the pipette recovery portion is provided with a second accommodating cavity for placing discarded pipettes.

3. The extractor according to claim 1 or 2, wherein A refrigeration module is provided below the workbench. The refrigeration module is placed below the sample placement portion and is used to keep the sample solution in a low-temperature environment.

4. The extractor according to claim 3, wherein A magnetic mechanism is provided between the refrigeration module and the sample placement portion, the magnetic mechanism being used to attract magnetic beads in the sample solution, and the magnetic mechanism being configured to be able to move up and down relative to the sample placement portion; And / or, the extractor includes a mounting bracket, the mounting bracket includes a first support platform and a second support platform spaced apart in an upper and lower direction, the first support platform and the second support platform are connected by a support rod, the workbench is installed on the first support platform, and the refrigeration module is placed between the first support platform and the second support platform.

5. The extractor according to claim 4, characterized in that The magnetic mechanism includes a heat-conducting plate and a magnet, wherein the magnet is provided on the upper surface of the heat-conducting plate; the refrigeration module includes a semiconductor refrigerator, wherein the cooling surface of the semiconductor refrigerator is in contact with the lower surface of the heat-conducting plate; And / or, the extractor also includes a lifting mechanism, the lifting mechanism includes a fixed frame and a support member, the fixed frame is provided with a guide column, the support member is slidably matched with the guide column, and the magnetic mechanism is arranged on the support member; the lifting mechanism also includes a lifting motor and a screw, the lifting motor is transmission-connected to the screw, and the support member is provided with a screw sliding sleeve portion threadedly connected to the screw; the axes of the screw and the guide column are parallel and extend along the moving direction of the magnetic mechanism.

6. The extractor according to claim 5, characterized in that The extractor further comprises a radiator, which is arranged on one side of the heating surface of the semiconductor refrigerator.

7. The extractor according to any one of claims 1 to 6, wherein The extractor further comprises an outer shell, wherein the pipetting unit and the workbench are built into the outer shell; a sterilization mechanism is installed on the top inner wall of the outer shell; and / or a lighting mechanism is installed on the top inner wall of the outer shell; And / or, the first driving device includes a first driving motor and a first screw rod passing through the first moving bracket, the first screw rod extends along the first direction, a first guide member extending along the first direction is connected between the fixed bracket and the first moving bracket, the first moving bracket is provided with a sliding portion that slides with the first guide member, and the first driving motor is used to drive the first screw rod to rotate to drive the first moving bracket to move along the first direction.

8. The extractor according to any one of claims 1 to 7, wherein The second driving device includes a sliding rail and a sliding seat that are slidably connected, the sliding rail is fixed to the first motion bracket, the sliding rail extends along the second direction, and the sliding seat is fixed to the first motion component; The second driving device further includes a first driving assembly for driving the slide to move along the second direction.

9. The extractor according to claim 8, wherein The first driving assembly includes a second driving motor, a first driving wheel, a first driven wheel and a first conveyor belt. The first driving wheel and the first driven wheel are mounted on the first moving bracket and spaced apart along the second direction. The first driving wheel and the first driven wheel are connected by the first conveyor belt. The first driving wheel is connected by the second driving motor. The slide is mounted on the first conveyor belt.

10. The extractor according to any one of claims 1 to 9, characterized in that The third driving device includes a second driving assembly, a second screw and a connecting seat, a first guide assembly is provided between the first moving assembly and the second moving assembly, a second guide assembly is provided between the second moving assembly and the third moving assembly, the second screw is passed through the connecting seat and the connecting seat is connected to the third moving assembly, and the second driving assembly is used to drive the second screw to rotate so as to drive the second moving assembly and the third moving assembly to move up and down relative to the first moving assembly; 11. The extractor according to claim 13, wherein The second drive assembly includes a third drive motor, a second drive wheel, a second driven wheel, and a second conveyor belt, wherein the second drive wheel is provided on the output shaft of the third drive motor, the second driven wheel is mounted on the second screw, and the second drive wheel and the second driven wheel are connected by the second conveyor belt; And / or, a first travel switch assembly is provided on the first motion assembly and the second motion assembly, and the first travel switch assembly is configured to be triggered when the second motion assembly moves upward and / or downward relative to the first motion assembly to a preset position, so as to stop the movement of the second motion assembly; And / or, a second travel switch assembly is provided on the second motion component and the third motion component, and the second travel switch assembly is configured to be triggered when the third motion component moves upward and / or downward to a preset position relative to the second motion component, so that the third motion component stops moving.

12. The extractor according to any one of claims 1 to 11, characterized in that The third motion assembly is provided with a magnetic mounting plate and a fourth driving device, wherein the magnetic mounting plate is provided with a magnetic member, and the fourth driving device is used to drive the magnetic mounting plate to move along the length direction of the pipette; Preferably, the fourth driving device includes a fourth driving motor and a third screw, the fourth driving motor is drivingly connected to the third screw, the third screw extends along the length of the pipette and is mounted on the third motion assembly, and the magnetic member mounting plate is provided with a moving portion that is threadably engaged with the third screw; The magnetic component mounting plate is provided with a first guide portion, and the third motion assembly is provided with a second guide portion, wherein the first guide portion is configured to be able to slide with the second guide portion along the axial direction of the third screw; Preferably, a third driving wheel is provided on the output shaft of the fourth driving motor, a third driven wheel is provided on the third screw, and the third driving wheel and the third driven wheel are connected via a third conveyor belt.

13. The extractor according to claim 12, wherein The pipette has a liquid storage cavity, in which an adsorption member capable of being adsorbed by the magnetic member is disposed, and the fourth driving device is used to drive the magnetic member toward or away from the liquid storage cavity so that the magnetic member adsorbs the adsorption member or the magnetic member and the adsorption member lose interaction; Preferably, the adsorbent is an iron bead, and the outer diameter of the iron bead is 0.5 mm-1.5 mm; Preferably, the pipette includes a first tube body and a second tube body that are integrally connected, the liquid storage cavity is provided in the second tube body, the first tube body has a liquid suction channel connected to the liquid storage cavity, the size of the adsorbent is larger than the maximum inner diameter of the connecting port between the liquid suction channel and the liquid storage cavity, and the liquid storage cavity is preferably provided with an arc-shaped protrusion surrounding the connecting port between the liquid suction channel and the liquid storage cavity.

14. The extractor according to claim 13, wherein A first stopper is provided at one end of the liquid storage cavity away from the first tube body, the first stopper being used to prevent the adsorption member from leaving the liquid storage cavity, and a vent is provided on the first stopper, through which the liquid storage cavity is connected to the outside world; And / or, the inner diameter of the liquid suction channel gradually increases from an end away from the second tube body to an end close to the second tube body; And / or, a second limiting member is provided in the liquid storage chamber at the connecting port between the liquid suction channel and the liquid storage chamber, and the second limiting member is provided with a special-shaped through hole that passes through the liquid suction channel, and the special-shaped through hole is used for allowing liquid to circulate in the liquid storage chamber and the liquid suction channel, and the through hole is also used to prevent the adsorption member from leaving the liquid storage chamber.

15. The extractor according to claim 14, wherein The special-shaped through hole includes a first through hole and a second through hole circumferentially arranged around the first through hole, the first through hole and the second through hole are connected, and the size of the adsorption member is larger than the inner diameter of the first through hole and the second through hole; And / or, the side wall of the second limiting member is concave inward toward the central axis of the second limiting member to form a groove, and the groove and the inner wall of the liquid storage cavity form a third through hole that is connected to the liquid suction channel, and the third through hole is distributed along the circumference of the second limiting member, and the size of the adsorption member is larger than the inner diameter of the third through hole.

16. The extractor according to any one of claims 1 to 15, characterized in that The third moving component is also equipped with a pipette detachment mechanism, which includes a detachment plate. The third moving component is provided with a mounting rod, and the mounting rod is provided with a mounting portion for socketing the pipette. The detachment plate is located above the mounting portion, and the detachment plate is configured to be movable relative to the mounting rod so that the pipette is detached from the mounting rod due to the force of the detachment plate.

17. The extractor according to claim 16, wherein The pipette disengagement mechanism further includes a fifth drive motor, a mounting member, and a fourth screw, wherein the mounting member is fixed to the third motion assembly, the upper end of the fourth screw is mounted on the mounting member via a bearing and is transmission-connected to the fifth drive motor, the lower end of the fourth screw is penetrated by a connecting member, the connecting member is connected to the disengagement plate, the third motion assembly is provided with a guide member, the connecting member is slidably engaged with the guide member, and the fifth drive motor is used to drive the fourth screw to rotate so as to drive the connecting member to move along the axial direction of the fourth screw; Preferably, the connecting member includes a connecting plate and a connecting rod, two ends of the connecting rod are fixedly connected to the connecting plate and the detachment plate respectively, and the fourth screw is threadedly engaged with the connecting plate.

18. The extractor according to claim 16, wherein A fourth through hole is provided on the separation plate, the lower end of the mounting rod passes through the fourth through hole and is sleeved on the pipette, the mounting rod and the fourth through hole are loosely matched, the end of the pipette used for connection with the mounting rod is set as the first end, and the inner diameter of the fourth through hole is smaller than the outer diameter of the first end.

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