Lipids and lipid nanoparticles comprising the same

Abstract

Described are compounds, compositions, and methods for delivery of therapeutic, diagnostic, or prophylactic agents (for example, a nucleic acid).

Description

[0001] LIPIDS AND LIPID NANOPARTICLES COMPRISING THE SAME

[0002] CROSS-REFERENCE TO RELATED APPLICATION

[0003] This application claims priority to, and the benefit of U.S. Provisional Application 63 / 551,031, filed on February 7, 2024, the contents of which is hereby incorporated in its entirety.

[0004] BACKGROUND

[0005] Different types of nucleic acids are currently being developed as therapeutics for the prevention or treatment of a number of diseases. The effective and safe delivery of active agents such as diagnostic agents, small molecule drugs, proteins, and nucleic acids represents a continuing medical challenge. In particular, the delivery of nucleic acids to cells is made difficult by the relative instability and low cell permeability of such species.

[0006] Lipid-containing nanoparticle compositions, liposomes, and lipoplexes have proven effective as transport vehicles for active agents into cells and / or intracellular compartments. Though a variety of such lipid-containing nanoparticle compositions have been demonstrated, improvements in safety, efficacy, and specificity are still lacking.

[0007] Thus, there is a need to develop new lipids, including lipids that exhibit high efficacy and high safety to facilitate the delivery of therapeutic, diagnostics, and / or prophylactics such as nucleic acids to cells.

[0008] The compounds, compositions, and methods disclosed herein address these and other needs.

[0009] SUMMARY

[0010] The present disclosure provides compounds and uses thereof. Also provided are compositions including a compound described herein and an active agent. The present disclosure also provides methods of using the compositions for delivering an active agent to a subject.

[0011] Described herein are lipid compounds defined by Formula I: or a pharmaceutically acceptable salt thereof, wherein: A, M, R1, G, x and y are as defined herein.

[0012] Described herein are also lipid compounds with structure of the Formula II

[0013] Formula II or a pharmaceutically acceptable salt thereof, wherein: A, M, R1, R2, G, m, n, x and y are as defined herein.

[0014] Also, described herein are lipid compounds with the structure of Formula III

[0015] Formula III or a pharmaceutically acceptable salt thereof, wherein: A, M, R1, G, m, x and y are as defined herein.

[0016] Described herein are also lipid compounds with the structure of Formula IV

[0017] Formula IV or a pharmaceutically acceptable salt thereof, wherein: A, M, R1, L, m, x and y are as defined herein.

[0018] Described herein are compounds of Formula V : or a pharmaceutically acceptable salt thereof, wherein A, M, E, G, R1, R3, R4, m, x, y, and z are as defined herein. Described herein are compounds of Formula VI: or a pharmaceutically acceptable salt thereof, wherein A, M, G, R1, R5, m, x, y, and z are as defined herein. In some embodiments, wherein

[0019] In some embodiments, M is H, OH, ORb, CN, -C(=O)ORb, -NC(=O)Rb, -C(=O)NRb,

[0020] In some embodiments, Rbis H, C1-C6alkyl or C1-C6alkenyl. In some embodiments, i, j, k, p, q, and r are independently 0, 1, 2, 3 or 4. In some embodiments, m, n, x, y, and z are independently an integer from 1 to 15.

[0021] R1and R2are independently for each occurrence linear or cyclic alkyl, alkenyl, or alkynyl comprising of 3 to 25 carbons, or a branched alkyl or alkenyl comprising of 6 to 40 carbons.

[0022] R3is H, OH, ORa, CN, -C(=O)ORa, -NC(=O)Ra, -C(=O)NRa,

[0023] In some embodiments, R4is absent or -S-S-. In some embodiments, R5is -S-S-.

[0024] In some embodiments, L is selected from pharmaceutically acceptable salt thereof. In some embodiments, provided herein are compositions comprising a compound of formula I, II, III, IV, V, VI, or any combination thereof.

[0025] Provided herein are also methods for the delivery of agents (e.g., polynucleotides). In some embodiments, provided herein are methods for diagnosing, treating, or preventing diseases. In some embodiments, provided herein are methods for inducing an immune response agent against infection. In some embodiments, provided herein are methods for treating cancer. In some embodiments, provided herein are methods for treating an inflammation disease. In some embodiments, provided herein are methods to regulate the immune system for treating cancers and other immune disorders.

[0026] BRIEF DESCRIPTION OF THE DRAWINGS

[0027] The accompanying figures, which are incorporated in and constitute a part of this specification, illustrate several aspects described below. Fig. 1 illustrates representative synthesis routes for GTX018, GTX187, and GTX188.

[0028] Fig. 2 illustrates representative synthesis route for ionizable lipids GTX215 and GTX216.

[0029] Fig. 3 illustrates representative synthesis route for biodegradable ionizable lipids with S-S bond, GTX025 and GTX225.

[0030] Fig. 4 illustrates representative synthesis route for ionizable lipids GTX046 and GTX047, with anti-oxidant 7-dehydrocholesterol (7-DHC) tail.

[0031] Fig. 5 illustrates representative synthesis route for ionizable lipid GTX019.

[0032] Fig. 6 illustrates representative synthesis route for ionizable lipids GTX325, GTX345, and GTX355.

[0033] Fig. 7 illustrates representative synthesis route for ionizable lipid GTX045.

[0034] Fig. 8A-8H shows1H NMR spectra for ionizable lipids. (8A)1H NMR spectra for GTX187, (8B)1H NMR spectra for GTX087, (8C) NMR spectra for GTX045, (8D)1H NMR spectra for GTX018 (8E) NMR spectra for GTX215, (8F) H NMR spectra for GTX047 (8G) ‘H NMR spectra for GTX046 (8H) ‘ H NMR spectra for GTXO 19.

[0035] Fig. 9 shows fluorescent and bright field images of cells transfected with EGFP mRNA- LNP at 500 ng in 24-well plate for 24 hours. LNPs were formulated using GTX187 or SM-102.

[0036] Fig. 10 shows whole animal IVIS imaging of mice injected with Luciferase mRNA- LNP after 6 hours injection of 1 ug mRNA (I.M. injection). LNPs were formulated using SM- 102, GTX 187 and GTX 188.

[0037] Fig. 11A-1 ID shows evaluation of influenza mRNA-LNP vaccine targeting PR8 virus strain. (11A) illustrates mouse study as scheduled including 2 immunizations on day 0 and day 14, blood draw on day 27, and virus challenge on day 28. (1 IB) shows a graph of neutralizing antibody titer of indicated vaccine groups. (11C) shows a graph of IgG titer of indicated vaccine groups. (1 ID) shows a graph of mouse body weight loss after virus challenge (20% of body weight loss consider death).

[0038] Fig. 12 shows whole animal IVIS imaging of mice injected with Luciferase mRNA- LNP after 6 hours injection of 1 ug mRNA (I.M. injection). LNPs were formulated using GTX 187, GTX 189, and SM-102.

[0039] Fig. 13 shows whole animal IVIS imaging of mice injected with Luciferase mRNA- LNP after 6 hours injection of 1 ug mRNA (I.M. injection). LNPs were formulated using GTX045 and SM-102. Fig. 14 shows animal IVIS imaging of mice injected with Luciferase mRNA-LNP after 6 hours injection of 1 ug mRNA (I.M. injection). LNPs were formulated using C1A5.

[0040] Fig. 15 shows whole animal IVIS imaging of mice injected with Luciferase mRNA- LNP after 6 hours injection of 1 ug mRNA (I.M. injection). LNPs were formulated using F1F5.

[0041] Fig. 16 shows whole animal IVIS imaging of mice injected with Luciferase mRNA- LNP after 6 hours injection of 1 ug mRNA (I.M. injection). LNPs were formulated using GTX355

[0042] DETAILED DESCRIPTION

[0043] The present disclosure provides new compounds, nanomaterials, and uses thereof. Also provided are compositions including a compound of the invention and an agent. The present disclosure also provides methods using the compositions for delivering an agent to a subject. These nanomaterials are used in applications such as gene therapy and drug delivery.

[0044] Reference will now be made in detail to the embodiments of the invention, examples of which are illustrated in the drawings and the examples. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

[0045] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood to one of ordinary skill in the art to which this invention belongs. The following definitions are provided for the full understanding of terms used in this specification.

[0046] Definitions

[0047] General Definitions

[0048] For the sake of clarify and readability, the following scientific background information and definitions are provided. Any technical features disclosed thereby can be part of each and every embodiment of the invention. Additional definitions and explanations can be provided in the context of this disclosure.

[0049] Unless defined otherwise, or unless the specific context requires otherwise, all technical terms used herein have the same meaning as is commonly understood by a person skilled in the relevant technical field.

[0050] As used in this specification and the following claims, the terms “comprise” (as well as forms, derivatives, or variations thereof, such as “comprising” and “comprises”) and “include” (as well as forms, derivatives, or variations thereof, such as “including” and “includes”) are inclusive (i.e., open-ended) and do not exclude additional elements or steps. For example, the terms "comprise" and / or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and / or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and / or groups thereof. Other than where noted, all numbers expressing quantities of ingredients, reaction conditions, geometries, dimensions, and so forth used in the specification and claims are to be understood at the very least, and not as an attempt to limit the application of the doctrine of equivalents to the scope of the claims, to be construed in light of the number of significant digits and ordinary rounding approaches.

[0051] Accordingly, these terms are intended to not only cover the recited element(s) or step(s), but may also include other elements or steps not expressly recited. Furthermore, as used herein, the use of the terms “a”, “an”, and “the” when used in conjunction with an element may mean “one,” but it is also consistent with the meaning of “one or more,” “at least one,” and “one or more than one.” Therefore, an element preceded by “a” or “an” does not, without more constraints, preclude the existence of additional identical elements.

[0052] Ranges can be expressed herein as from “about” one particular value, and / or to “about” another particular value. By “about” is meant within 5% of the value, e.g., within 4, 3, 2, or 1% of the value. When such a range is expressed, another aspect includes from the one particular value and / or to the other particular value. Similarly, when values are expressed as approximations, by use of the antecedent “about,” it will be understood that the particular value forms another aspect. It will be further understood that the endpoints of each of the ranges are significant both in relation to the other endpoint, and independently of the other endpoint. It is also understood that there are a number of values disclosed herein, and that each value is also herein disclosed as “about” that particular value in addition to the value itself. For example, if the value “10” is disclosed, then “about 10” is also disclosed. A range may be construed to include the start and the end of the range. For example, a range of 10% to 20% (i.e., range of 10%-20%) can includes 10% and also includes 20%, and includes percentages in between 10% and 20%, unless explicitly stated otherwise herein.

[0053] The terms “inflammation” and “inflammatory” refer to a biologic response involving an upregulation of the immune system, which may include an increase in protein activity related to inflammation or an immune response (e.g., pro-inflammatory markers such as chemokines and cytokines) and symptoms of inflammation (e.g., pain, heat, redness and / or edema). Inflammation is acute or chronic.

[0054] The term “anti-inflammatory agent” includes agents that elicit a biological or medical response in a subject that reduce inflammation (either acute or chronic) or downregulate the immune response, for example, by reducing or inhibiting enzyme or protein activity related to inflammation or an immune response; by ameliorating one or more symptoms of inflammation or an immune response; or by slowing or delaying of the inflammatory process or the immune response.

[0055] As used herein, the terms "may," "optionally," and "may optionally" are used interchangeably and are meant to include cases in which the condition occurs as well as cases in which the condition does not occur. Thus, for example, the statement that a formulation "may include an excipient" is meant to include cases in which the formulation includes an excipient as well as cases in which the formulation does not include an excipient.

[0056] It is understood that when combinations, subsets, groups, etc. of elements are disclosed (e.g., combinations of components in a composition, or combinations of steps in a method), that while specific reference of each of the various individual and collective combinations and permutations of these elements may not be explicitly disclosed, each is specifically contemplated and described herein.

[0057] “Administration" to a subject includes any route of introducing or delivering to a subject an agent. Administration can be carried out by any suitable route, including oral, topical, transcutaneous, transdermal, intra-joint, intra-arteriole, intradermal, intraventricular, intralesional, intranasal, rectal, vaginal, by inhalation, via an implanted reservoir, parenteral (e.g., subcutaneous, intravenous, intramuscular, intra- articular, intra-synovial, intrasternal, intrathecal, intraperitoneal, intrahepatic, intralesional, and intracranial injections or infusion techniques), and the like. "Concurrent administration", "administration in combination", "simultaneous administration" or "administered simultaneously" as used herein, means that the compounds are administered at the same point in time or essentially immediately following one another. In the latter case, the two compounds are administered at times sufficiently close that the results observed are indistinguishable from those achieved when the compounds are administered at the same point in time. "Systemic administration" refers to the introducing or delivering to a subject an agent via a route which introduces or delivers the agent to extensive areas of the subject's body (e.g. greater than 50% of the body), for example through entrance into the circulatory or lymph systems. By contrast, "local administration" refers to the introducing or delivery to a subject an agent via a route which introduces or delivers the agent to the area or area immediately adjacent to the point of administration and does not introduce the agent systemically in a therapeutically significant amount. For example, locally administered agents are easily detectable in the local vicinity of the point of administration but are undetectable or detectable at negligible amounts in distal parts of the subject's body. Administration includes self-administration and the administration by another.

[0058] As used here, the terms “beneficial agent” and “active agent” are used interchangeably herein to refer to a chemical compound or composition that has a beneficial biological effect. Beneficial biological effects include both therapeutic effects, i.e., treatment of a disorder or other undesirable physiological condition, and prophylactic effects, i.e., prevention of a disorder or other undesirable physiological condition. The terms also encompass pharmaceutically acceptable, pharmacologically active derivatives of beneficial agents specifically mentioned herein, including, but not limited to, salts, esters, amides, prodrugs, active metabolites, isomers, fragments, analogs, and the like. When the terms “beneficial agent” or “active agent” are used, then, or when a particular agent is specifically identified, it is to be understood that the term includes the agent per se as well as pharmaceutically acceptable, pharmacologically active salts, esters, amides, prodrugs, conjugates, active metabolites, isomers, fragments, analogs, etc.

[0059] “Therapeutic agent” refers to any composition that has a beneficial biological effect. Beneficial biological effects include both therapeutic effects, e.g., treatment of a disorder or other undesirable physiological condition, and prophylactic effects, e.g., prevention of a disorder or other undesirable physiological condition. The terms also encompass pharmaceutically acceptable, pharmacologically active derivatives of beneficial agents specifically mentioned herein, including, but not limited to, salts, esters, amides, proagents, active metabolites, isomers, fragments, analogs, and the like. When the term “therapeutic agent” is used, or when a particular agent is specifically identified, it is to be understood that the term includes the agent per se as well as pharmaceutically acceptable, pharmacologically active salts, esters, amides, proagents, conjugates, active metabolites, isomers, fragments, analogs, etc.

[0060] "Inhibit," "inhibiting," and "inhibition" mean to decrease an activity, response, condition, disease, or other biological parameter. This can include but is not limited to the complete ablation of the activity, response, condition, or disease. This may also include, for example, a 10% reduction in the activity, response, condition, or disease as compared to the native or control level. Thus, the reduction can be a 10, 20, 30, 40, 50, 60, 70, 80, 90, 100%, or any amount of reduction in between as compared to native or control levels.

[0061] “Inactivate”, “inactivating” and “inactivation” means to decrease or eliminate an activity, response, condition, disease, or other biological parameter due to a chemical (covalent bond formation) between the ligand and a its biological target.

[0062] By “reduce” or other forms of the word, such as “reducing” or “reduction,” is meant lowering of an event or characteristic (e.g., tumor growth). It is understood that this is typically in relation to some standard or expected value, in other words it is relative, but that it is not always necessary for the standard or relative value to be referred to. For example, “reduces tumor growth” means reducing the rate of growth of a tumor relative to a standard or a control.

[0063] As used herein, the terms “treating” or “treatment” of a subject includes the administration of a drug to a subject with the purpose of preventing, curing, healing, alleviating, relieving, altering, remedying, ameliorating, improving, stabilizing or affecting a disease or disorder, or a symptom of a disease or disorder. The terms “treating” and “treatment” can also refer to reduction in severity and / or frequency of symptoms, elimination of symptoms and / or underlying cause, prevention of the occurrence of symptoms and / or their underlying cause, and improvement or remediation of damage.

[0064] By “prevent” or other forms of the word, such as “preventing” or “prevention,” is meant to stop a particular event or characteristic, to stabilize or delay the development or progression of a particular event or characteristic, or to minimize the chances that a particular event or characteristic will occur. Prevent does not require comparison to a control as it is typically more absolute than, for example, reduce. As used herein, something could be reduced but not prevented, but something that is reduced could also be prevented. Likewise, something could be prevented but not reduced, but something that is prevented could also be reduced. It is understood that where reduce or prevent are used, unless specifically indicated otherwise, the use of the other word is also expressly disclosed. For example, the terms “prevent” or “suppress” can refer to a treatment that forestalls or slows the onset of a disease or condition or reduced the severity of the disease or condition. Thus, if a treatment can treat a disease in a subject having symptoms of the disease, it can also prevent or suppress that disease in a subject who has yet to suffer some or all of the symptoms. As used herein, the term “preventing” a disorder or unwanted physiological event in a subject refers specifically to the prevention of the occurrence of symptoms and / or their underlying cause, wherein the subject may or may not exhibit heightened susceptibility to the disorder or event. By the term “effective amount” of a therapeutic agent is meant a nontoxic but sufficient amount of a beneficial agent to provide the desired effect. The amount of beneficial agent that is “effective” will vary from subject to subject, depending on the age and general condition of the subject, the particular beneficial agent or agents, and the like. Thus, it is not always possible to specify an exact “effective amount”. However, an appropriate “effective’ amount in any subject case may be determined by one of ordinary skill in the art using routine experimentation. Also, as used herein, and unless specifically stated otherwise, an “effective amount” of a beneficial can also refer to an amount covering both therapeutically effective amounts and prophylactically effective amounts.

[0065] An “effective amount” of a drug necessary to achieve a therapeutic effect may vary according to factors such as the age, sex, and weight of the subject. Dosage regimens can be adjusted to provide the optimum therapeutic response. For example, several divided doses may be administered daily or the dose may be proportionally reduced as indicated by the exigencies of the therapeutic situation.

[0066] As used herein, a “therapeutically effective amount” of a therapeutic agent refers to an amount that is effective to achieve a desired therapeutic result, and a “prophylactically effective amount” of a therapeutic agent refers to an amount that is effective to prevent an unwanted physiological condition. Therapeutically effective and prophylactically effective amounts of a given therapeutic agent will typically vary with respect to factors such as the type and severity of the disorder or disease being treated and the age, gender, and weight of the subject. The term “therapeutically effective amount” can also refer to an amount of a therapeutic agent, or a rate of delivery of a therapeutic agent (e.g., amount over time), effective to facilitate a desired therapeutic effect. The precise desired therapeutic effect will vary according to the condition to be treated, the tolerance of the subject, the drug and / or drug formulation to be administered (e.g., the potency of the therapeutic agent (drug), the concentration of drug in the formulation, and the like), and a variety of other factors that are appreciated by those of ordinary skill in the art.

[0067] As used herein, the term “pharmaceutically acceptable” component can refer to a component that is not biologically or otherwise undesirable, i.e., the component may be incorporated into a pharmaceutical formulation of the invention and administered to a subject as described herein without causing any significant undesirable biological effects or interacting in a deleterious manner with any of the other components of the formulation in which it is contained. When the term “pharmaceutically acceptable” is used to refer to an excipient, it is generally implied that the component has met the required standards of toxicological and manufacturing testing or that it is included on the Inactive Ingredient Guide prepared by the U.S. Food and Drug Administration.

[0068] "Pharmaceutically acceptable carrier" (sometimes referred to as a "carrier") means a carrier or excipient that is useful in preparing a pharmaceutical or therapeutic composition that is generally safe and non-toxic and includes a carrier that is acceptable for veterinary and / or human pharmaceutical or therapeutic use. The terms "carrier" or "pharmaceutically acceptable carrier" can include, but are not limited to, phosphate buffered saline solution, water, emulsions (such as an oil / water or water / oil emulsion) and / or various types of wetting agents. As used herein, the term "carrier" encompasses, but is not limited to, any excipient, diluent, filler, salt, buffer, stabilizer, solubilizer, lipid, stabilizer, or other material well known in the art for use in pharmaceutical formulations and as described further herein.

[0069] As used herein, “pharmaceutically acceptable salt” is a derivative of the disclosed compound in which the parent compound is modified by making inorganic and organic, nontoxic, acid or base addition salts thereof. The salts of the present compounds can be synthesized from a parent compound that contains a basic or acidic moiety by conventional chemical methods. Generally, such salts can be prepared by reacting free acid forms of these compounds with a stoichiometric amount of the appropriate base (such as Na, Ca, Mg, or K hydroxide, carbonate, bicarbonate, or the like), or by reacting free base forms of these compounds with a stoichiometric amount of the appropriate acid. Such reactions are typically carried out in water or in an organic solvent, or in a mixture of the two. Generally, non-aqueous media like ether, ethyl acetate, ethanol, isopropanol, or acetonitrile are typical, where practicable. Salts of the present compounds further include solvates of the compounds and of the compound salts.

[0070] Examples of pharmaceutically acceptable salts include, but are not limited to, mineral or organic acid salts of basic residues such as amines; alkali or organic salts of acidic residues such as carboxylic acids; and the like. The pharmaceutically acceptable salts include the conventional non-toxic salts and the quaternary ammonium salts of the parent compound formed, for example, from non-toxic inorganic or organic acids. For example, conventional non-toxic acid salts include those derived from inorganic acids such as hydrochloric, hydrobromic, sulfuric, sulfamic, phosphoric, nitric and the like; and the salts prepared from organic acids such as acetic, propionic, succinic, glycolic, stearic, lactic, malic, tartaric, citric, ascorbic, pamoic, maleic, hydroxy maleic, phenylacetic, glutamic, benzoic, salicylic, mesylic, esylic, besylic, sulfanilic, 2-acetoxybenzoic, fumaric, toluenesulfonic, methanesulfonic, ethane disulfonic, oxalic, isethionic, H00C-(CH2)n- COOH where n is 0-4, and the like, or using a different acid that produces the same counterion. Lists of additional suitable salts may be found, e.g., in Remington's Pharmaceutical Sciences, 17th ed., Mack Publishing Company, Easton, Pa., p. 1418 (1985).

[0071] Also, as used herein, the term “pharmacologically active” (or simply “active”), as in a “pharmacologically active” derivative or analog, can refer to a derivative or analog (e.g., a salt, ester, amide, conjugate, metabolite, isomer, fragment, etc.) having the same type of pharmacological activity as the parent compound and approximately equivalent in degree.

[0072] A “control” is an alternative subject or sample used in an experiment for comparison purposes. A control can be "positive" or "negative."

[0073] As used herein, by a “subject” is meant an individual. Thus, the “subject” can include domesticated animals (e.g., cats, dogs, etc.), livestock (e.g., cattle, horses, pigs, sheep, goats, etc.), laboratory animals (e.g., mouse, rabbit, rat, guinea pig, goats, sheep, pigs, dogs, cats, etc.), and birds (e.g., chickens, turkeys, songbirds, etc.). “Subject” can also include a mammal, such as a primate or a human. Thus, the subject can be a human or veterinary patient. The term “patient” refers to a subject under the treatment of a clinician, e.g., physician. Administration of the therapeutic agents can be carried out at dosages and for periods of time effective for treatment of a subject. In some embodiments, the subject is a human.

[0074] The term “nucleic acid” as used herein means a polymer composed of nucleotides, e.g. deoxyribonucleotides or ribonucleotides.

[0075] The terms “ribonucleic acid” and “RNA” as used herein mean a polymer composed of ribonucleotides.

[0076] The terms “deoxyribonucleic acid” and “DNA” as used herein mean a polymer composed of deoxyribonucleo tides.

[0077] The term “oligonucleotide” denotes single- or double-stranded nucleotide multimers of from about 2 to up to about 100 nucleotides in length. Suitable oligonucleotides may be prepared by the phosphoramidite method described by Beaucage and Carruthers, Tetrahedron Lett., 22:1859-1862 (1981), or by the triester method according to Matteucci, et al., J. Am. Chem. Soc., 103:3185 (1981), both incorporated herein by reference, or by other chemical methods using either a commercial automated oligonucleotide synthesizer or VLSIPS™ technology. When oligonucleotides are referred to as “double-stranded,” it is understood by those of skill in the art that a pair of oligonucleotides exist in a hydrogen-bonded, helical array typically associated with, for example, DNA. In addition to the 100% complementary form of double-stranded oligonucleotides, the term “double- stranded,” as used herein is also meant to refer to those forms which include such structural features as bulges and loops, described more fully in such biochemistry texts as Stryer, Biochemistry, Third Ed., (1988), incorporated herein by reference for all purposes.

[0078] The term “polynucleotide” refers to a single or double stranded polymer composed of nucleotide monomers. In some embodiments, the polynucleotide is composed of nucleotide monomers of generally greater than 100 nucleotides in length and up to about 8,000 or more nucleotides in length.

[0079] The term “polypeptide” refers to a compound made up of a single chain of D- or L- amino acids or a mixture of D- and L-amino acids joined by peptide bonds.

[0080] The term “complementary” refers to the topological compatibility or matching together of interacting surfaces of a probe molecule and its target. Thus, the target and its probe can be described as complementary, and furthermore, the contact surface characteristics are complementary to each other.

[0081] The term “recombinant” refers to a human manipulated nucleic acid (e.g. polynucleotide) or a copy or complement of a human manipulated nucleic acid (e.g. polynucleotide), or if in reference to a protein (i.e, a “recombinant protein”), a protein encoded by a recombinant nucleic acid (e.g. polynucleotide). In embodiments, a recombinant expression cassette comprising a promoter operably linked to a second nucleic acid (e.g. polynucleotide) may include a promoter that is heterologous to the second nucleic acid (e.g. polynucleotide) as the result of human manipulation (e.g., by methods described in Sambrook et al., Molecular Cloning — A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., (1989) or Current Protocols in Molecular Biology Volumes 1-3, John Wiley & Sons, Inc. (1994-1998)). In another example, a recombinant expression cassette may comprise nucleic acids (e.g. polynucleotides) combined in such a way that the nucleic acids (e.g. polynucleotides) are extremely unlikely to be found in nature. For instance, human manipulated restriction sites or plasmid vector sequences may flank or separate the promoter from the second nucleic acid (e.g. polynucleotide). One of skill will recognize that nucleic acids (e.g. polynucleotides) can be manipulated in many ways and are not limited to the examples above. Chemical Definitions

[0082] As used herein, the term “substituted” is contemplated to include all permissible substituents of organic compounds. In a broad aspect, the permissible substituents include acyclic and cyclic, branched and unbranched, carbocyclic and heterocyclic, and aromatic and nonaromatic substituents of organic compounds. Illustrative substituents include, for example, those described below. The permissible substituents can be one or more and the same or different for appropriate organic compounds. For purposes of this disclosure, the heteroatoms, such as nitrogen, can have hydrogen substituents and / or any permissible substituents of organic compounds described herein which satisfy the valences of the heteroatoms. This disclosure is not intended to be limited in any manner by the permissible substituents of organic compounds. Also, the terms “substitution” or “substituted with” include the implicit proviso that such substitution is in accordance with permitted valence of the substituted atom and the substituent, and that the substitution results in a stable compound, e.g., a compound that does not spontaneously undergo transformation such as by rearrangement, cyclization, elimination, etc.

[0083] “Z1,” “Z2,” “Z3,” and “Z4” are used herein as generic symbols to represent various specific substituents. These symbols can be any substituent, not limited to those disclosed herein, and when they are defined to be certain substituents in one instance, they can, in another instance, be defined as some other substituents.

[0084] The term “aliphatic” as used herein refers to a non-aromatic hydrocarbon group and includes branched and unbranched, alkyl, alkenyl, or alkynyl groups.

[0085] The term “alkyl” as used herein is a branched or unbranched saturated hydrocarbon group of 1 to 24 carbon atoms, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, t- butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, dodecyl, tetradecyl, hexadecyl, eicosyl, tetracosyl, and the like. The alkyl group can also be substituted or unsubstituted. The alkyl group can be substituted with one or more groups including, but not limited to, alkyl, halogenated alkyl, alkoxy, alkenyl, alkynyl, aryl, heteroaryl, aldehyde, amino, carboxylic acid, ester, ether, halide, hydroxy, ketone, nitro, silyl, sulfo-oxo, sulfonyl, sulfone, sulfoxide, or thiol, as described below.

[0086] Throughout the specification “alkyl” is generally used to refer to both unsubstituted alkyl groups and substituted alkyl groups; however, substituted alkyl groups are also specifically referred to herein by identifying the specific substituent(s) on the alkyl group. For example, the term “halogenated alkyl” specifically refers to an alkyl group that is substituted with one or more halide, e.g., fluorine, chlorine, bromine, or iodine. The term “alkoxyalkyl” specifically refers to an alkyl group that is substituted with one or more alkoxy groups, as described below. The term “alkylamino” specifically refers to an alkyl group that is substituted with one or more amino groups, as described below, and the like. When “alkyl” is used in one instance and a specific term such as “alkylalcohol” is used in another, it is not meant to imply that the term “alkyl” does not also refer to specific terms such as “alkylalcohol” and the like.

[0087] This practice is also used for other groups described herein. That is, while a term such as “cycloalkyl” refers to both unsubstituted and substituted cycloalkyl moieties, the substituted moieties can, in addition, be specifically identified herein; for example, a particular substituted cycloalkyl can be referred to as, e.g., an “alkylcycloalkyl.” Similarly, a substituted alkoxy can be specifically referred to as, e.g., a “halogenated alkoxy,” a particular substituted alkenyl can be, e.g., an “alkenylalcohol,” and the like. Again, the practice of using a general term, such as “cycloalkyl,” and a specific term, such as “alkylcycloalkyl,” is not meant to imply that the general term does not also include the specific term.

[0088] The term “alkoxy” as used herein is an alkyl group bound through a single, terminal ether linkage; that is, an “alkoxy” group can be defined as — OZ1where Z1is alkyl as defined above.

[0089] The term “alkenyl” as used herein is a hydrocarbon group of from 2 to 24 carbon atoms with a structural formula containing at least one carbon-carbon double bond. Asymmetric structures such as (Z'Z2)C=C(Z3Z4) are intended to include both the E and Z isomers. This can be presumed in structural formulae herein wherein an asymmetric alkene is present, or it can be explicitly indicated by the bond symbol C=C. The alkenyl group can be substituted with one or more groups including, but not limited to, alkyl, halogenated alkyl, alkoxy, alkenyl, alkynyl, aryl, heteroaryl, aldehyde, amino, carboxylic acid, ester, ether, halide, hydroxy, ketone, nitro, silyl, sulfo-oxo, sulfonyl, sulfone, sulfoxide, or thiol, as described below.

[0090] The term “alkynyl” as used herein is a hydrocarbon group of 2 to 24 carbon atoms with a structural formula containing at least one carbon-carbon triple bond. The alkynyl group can be substituted with one or more groups including, but not limited to, alkyl, halogenated alkyl, alkoxy, alkenyl, alkynyl, aryl, heteroaryl, aldehyde, amino, carboxylic acid, ester, ether, halide, hydroxy, ketone, nitro, silyl, sulfo-oxo, sulfonyl, sulfone, sulfoxide, or thiol, as described below.

[0091] The term “aryl” as used herein is a group that contains any carbon-based aromatic group including, but not limited to, benzene, naphthalene, phenyl, biphenyl, phenoxybenzene, and the like. The term “heteroaryl” is defined as a group that contains an aromatic group that has at least one heteroatom incorporated within the ring of the aromatic group. Examples of heteroatoms include, but are not limited to, nitrogen, oxygen, sulfur, and phosphorus. The term “non-heteroaryl,” which is included in the term “aryl,” defines a group that contains an aromatic group that does not contain a heteroatom. The aryl or heteroaryl group can be substituted or unsubstituted. The aryl or heteroaryl group can be substituted with one or more groups including, but not limited to, alkyl, halogenated alkyl, alkoxy, alkenyl, alkynyl, aryl, heteroaryl, aldehyde, amino, carboxylic acid, ester, ether, halide, hydroxy, ketone, nitro, silyl, sulfo-oxo, sulfonyl, sulfone, sulfoxide, or thiol as described herein. The term “biaryl” is a specific type of aryl group and is included in the definition of aryl. Biaryl refers to two aryl groups that are bound together via a fused ring structure, as in naphthalene, or are attached via one or more carbon-carbon bonds, as in biphenyl.

[0092] The term “cycloalkyl” as used herein is a non-aromatic carbon-based ring composed of at least three carbon atoms. Examples of cycloalkyl groups include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, etc. The term “heterocycloalkyl” is a cycloalkyl group as defined above where at least one of the carbon atoms of the ring is substituted with a heteroatom such as, but not limited to, nitrogen, oxygen, sulfur, or phosphorus. The cycloalkyl group and heterocycloalkyl group can be substituted or unsubstituted. The cycloalkyl group and heterocycloalkyl group can be substituted with one or more groups including, but not limited to, alkyl, alkoxy, alkenyl, alkynyl, aryl, heteroaryl, aldehyde, amino, carboxylic acid, ester, ether, halide, hydroxy, ketone, nitro, silyl, sulfo-oxo, sulfonyl, sulfone, sulfoxide, or thiol as described herein.

[0093] The term “cycloalkenyl” as used herein is a non-aromatic carbon-based ring composed of at least three carbon atoms and containing at least one double bound, i.e., C=C. Examples of cycloalkenyl groups include, but are not limited to, cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclopentadienyl, cyclohexenyl, cyclohexadienyl, and the like. The term “heterocycloalkenyl” is a type of cycloalkenyl group as defined above, and is included within the meaning of the term “cycloalkenyl,” where at least one of the carbon atoms of the ring is substituted with a heteroatom such as, but not limited to, nitrogen, oxygen, sulfur, or phosphorus. The cycloalkenyl group and heterocycloalkenyl group can be substituted or unsubstituted. The cycloalkenyl group and heterocycloalkenyl group can be substituted with one or more groups including, but not limited to, alkyl, alkoxy, alkenyl, alkynyl, aryl, heteroaryl, aldehyde, amino, carboxylic acid, ester, ether, halide, hydroxy, ketone, nitro, silyl, sulfo-oxo, sulfonyl, sulfone, sulfoxide, or thiol as described herein.

[0094] The term “cyclic group” is used herein to refer to either aryl groups, non-aryl groups i.e., cycloalkyl, heterocycloalkyl, cycloalkenyl, and heterocycloalkenyl groups), or both. Cyclic groups have one or more ring systems that can be substituted or unsubstituted. A cyclic group can contain one or more aryl groups, one or more non-aryl groups, or one or more aryl groups and one or more non-aryl groups.

[0095] The term “aldehyde” as used herein is represented by the formula — C(O)H. Throughout this specification “C(O)” or “CO” is a short hand notation for C~O.

[0096] The terms “amine” or “amino” as used herein are represented by the formula — NZ’Z2. where Z1and Z2can each be substitution group as described herein, such as hydrogen, an alkyl, halogenated alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group described above.

[0097] The term “carboxylic acid” as used herein is represented by the formula — C(O)OH. A “carboxylate” or “carboxyl” group as used herein is represented by the formula — C(O)O’-

[0098] The term “ester” as used herein is represented by the formula — OC(O)Z1or — C(O)OZ1, where Z1can be an alkyl, halogenated alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group described above.

[0099] The term “ether” as used herein is represented by the formula Z'OZ2, where Z1and Z2can be, independently, an alkyl, halogenated alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group described above.

[0100] The term “ketone” as used herein is represented by the formula Z1C(O)Z2, where Z1and Z2can be, independently, an alkyl, halogenated alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group described above.

[0101] The term “halide” or “halogen” as used herein refers to the fluorine, chlorine, bromine, and iodine.

[0102] The term “hydroxyl” as used herein is represented by the formula — OH.

[0103] The term “nitro” as used herein is represented by the formula — NO2.

[0104] The term “silyl” as used herein is represented by the formula — SiZ^Z3, where Z1, Z2, andZ3can be, independently, hydrogen, alkyl, halogenated alkyl, alkoxy, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group described above.

[0105] The term “sulfonyl” is used herein to refer to the sulfo-oxo group represented by the formula — S(O)2Z1, where Z1can be hydrogen, an alkyl, halogenated alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group described above. The term “sulfonylamino” or “sulfonamide” as used herein is represented by the formula — S(O)2NH — .

[0106] The term “phosphonyl” is used herein to refer to the phospho-oxo group represented by the formula — P(O)(OZ1)2, where Z1can be hydrogen, an alkyl, halogenated alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group described above.

[0107] The term “thiol” as used herein is represented by the formula — SH.

[0108] The term “thio” as used herein is represented by the formula — S — .

[0109] “R1,” “R2,” “R3,” “Rn,” etc., where n is some integer, as used herein can, independently, possess one or more of the groups listed above. For example, if R1is a straight chain alkyl group, one of the hydrogen atoms of the alkyl group can optionally be substituted with a hydroxyl group, an alkoxyl group, an amine group, an alkyl group, a halide, and the like. Depending upon the groups that are selected, a first group can be incorporated within second group or, alternatively, the first group can be pendant (i.e.. attached) to the second group. For example, with the phrase “an alkyl group comprising an amino group,” the amino group can be incorporated within the backbone of the alkyl group. Alternatively, the amino group can be attached to the backbone of the alkyl group. The nature of the group(s) that is (are) selected will determine if the first group is embedded or attached to the second group.

[0110] As used herein, “ionizable lipid” refers to a lipid with a group or atom that can be charged (ionized) dependent upon the pH of the environment. Typically, the charge of a primary, secondary and tertiary amines is dependent upon the pH of the system. At low pH levels, these amines tend to be strongly cationic. At high pH levels these amines do not ionize.

[0111] Unless stated to the contrary, a formula with chemical bonds shown only as solid lines and not as wedges or dashed lines contemplates each possible isomer, e.g., each enantiomer, diastereomer, and meso compound, and a mixture of isomers, such as a racemic or scalemic mixture.

[0112] Reference will now be made in detail to specific aspects of the disclosed materials, compounds, compositions, articles, and methods, examples of which are illustrated in the accompanying Examples and Figures.

[0113] Compounds

[0114] Described herein are compounds of lipids. In some embodiments, described herein are compounds of Formula I:

[0115] Formula I or a pharmaceutically acceptable salt thereof, wherein: Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independently 0, 1, 2, 3 or 4; x and y are independently an integer from 1 to 15;

[0116] R1is independently for each occurrence linear or cyclic alkyl, alkenyl , or alkynyl comprising of 3 to 25 carbons, or a branched alkyl or alkenyl comprising of 6 to 40 carbons; and

[0117] In some embodiments, the compound of Formula I is defined by one of formulae la-

[0118] Ig:

[0119] Ig or a pharmaceutically acceptable salt thereof, wherein:

[0120] Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independently 0, 1, 2, 3 or 4; x and y are independently an integer from 1 to 15; R1is independently for each occurrence linear or cyclic alkyl, alkenyl , or alkynyl comprising of 3 to 25 carbons, or a branched alkyl or alkenyl comprising of 6 to 40 carbons; and In some embodiments, the compound of Formula I is a compound of formula la. In some embodiments, the lipid compound is a compound of formula lb. In some embodiments, the lipid compound is a compound of formula Ic. In some embodiments, the lipid compound is a compound of formula Id. In some embodiments, the lipid compound is a compound of formula le. In some embodiments, the lipid compound is a compound of formula If. In some embodiments, the lipid compound is a compound of formula Ig.

[0121] In some embodiments, R1is a linear C3-C25 alkyl or cycloalkyl. In some embodiments, R1is a linear C3-C25 alkynyl or cycloalkynyl. In some embodiments, R1is a linear C3-C25 alkenyl or cycloalkenyl. In some embodiments, R1is a branched C6-C40 alkyl. In some embodiments, R1is a branchedC6-C40 alkenyl. For example, in some embodiments, R1has the following structures: In some embodiments, the lipid compound of Formula I is selected from:

[0122]

[0123] Described herein are compounds of Formula II:

[0124] Formula II or a pharmaceutically acceptable salt thereof, wherein: Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independently 0, 1, 2, 3 or 4; m, n, x, and y are independently an integer from 1 to 15;

[0125] R1and R2are independently for each occurrence linear or cyclic alkyl, alkenyl, or alkynyl comprising of 3 to 25 carbons, or branched alkyl or alkenyl comprising of 6 to 40 carbons; and

[0126]

[0127] Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independently 0, 1, 2, 3 or 4; m, n, x, and y are independently an integer from 1 to 15;

[0128] R1and R2are independently for each occurrence linear or cyclic alkyl, alkenyl, or alkynyl consisting of 3 to 25 carbons, or a branched alkyl or alkenyl consisting of 6 to 40 carbons; and In some embodiments, the lipid compound is a compound of formula Ila. In some embodiments, the lipid compound is a compound of formula lib. In some embodiments, the lipid compound is a compound of formula lie. In some embodiments, the lipid compound is a compound of formula lid. In some embodiments, the lipid compound is a compound of formula lie.

[0129] In some embodiments, R1is a linear C3-C25 alkyl or C3-C25 cycloalkyl. In some embodiments, R1is a linear C3-C25 alkynyl or C3-C25 cycloalkynyl. In some embodiments, R1is a linear C3-C25 alkenyl or C3-C25 cycloalkenyl. In some embodiments of Formula II, R1is a branched -CC640 alkyl. In some embodiments, R1is a branched -C40 alkenyl. For exCa6mple, in some embodiments of Formula II, R1has the following structures:

[0130] In some embodiments of Formula I, II, III, and IV, R1is -CRbRc. In some embodiments, when R1is -CRbRc, then Rband Rcare C3 alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare C4 alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare Ci, alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare Cx alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare C10 alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare C12 alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare C14 alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare Cis alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare C20 alkyl.

[0131] In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C5 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C6alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis Cx alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, Rbis Ci alkyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C38 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C39 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C4 alkyl. In some embodiments, when R1is - CRbRc, then Rbis C2 alkyl and Rcis C6alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis Cs alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C14 alkyl. In some embodiments, Rbis C2 alkyl and Rcis Ci6 alkyl. In some embodiments, when R1is - CRbRc, then Rbis C2 alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C38 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C3 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C4 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis Ce alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis Cs alkyl. In some embodiments, when R1is - CRbRc, then Rbis C3 alkyl and Rcis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C37 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis Cs alkyl. In some embodiments, when R1is - CRbRc, then RbC6alkyl and Rcis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C24 alkyl. In some embodiments, when R1is - CRbRc, then Rbis C6alkyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C34 alkyl. In some embodiments, when R1is -CRbRc, then RbCx alkyl and Rcis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C14 alkyl. In some embodiments, when R1is - CRbRc, then Rbis Cs alkyl and Rcis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C30 alkyl. In some embodiments, when R1is - CRbRc, then Rbis Cs alkyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkyl and Rcis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkyl and Rcis C20 alkyl. In some embodiments, vhen R1is -CRbRc, then Rbis Cio alkyl and Icis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkyl and Rcis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cu alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cu alkyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cu alkyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cis alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cis alkyl and Rcis C22 alkyl.

[0132] In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C5 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C6alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis Cx alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis Cio alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis Ci6 alkyl, when R1is -CRbRc, then In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C38 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C39 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C4 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C6alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis Cx alkyl. In some embodiments, when R1is - CRbRc, then Rcis C2 alkyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C38 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C3 alkyl. In some embodiments, when R1is - CRbRc, then Rcis C3 alkyl and Rbis C4 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis G, alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis Cs alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C37 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis Cg alkyl. In some embodiments, when R1is -CRbRc, then RcC6alkyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis Ci8 alkyl. In some embodiments, when R1is - CRbRc, then Rcis C6alkyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C34 alkyl. In some embodiments, when R1is - CRbRc, then RcCg alkyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cg alkyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cg alkyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cg alkyl and Rbis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cg alkyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cg alkyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cg alkyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cg alkyl and Rbis C24 alkyl. In some embodiments, when R1is - CRbRc, then Rcis Cg alkyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis Ci6 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis Cis alkyl, In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C20 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C22 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C24 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C26 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C28 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C30 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Rbis C14 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Rbis Ci6 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Rbis Cis alkyl, In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Rbis C20 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Rbis C22 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Rbis C24 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Rbis C26 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Rbis C28 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and Rbis Ci6 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and Rbis Cis alkyl, In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and Rbis C20 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and Rbis C22 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and Rbis C24 alkyl, In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and Rbis C26 alkyl, In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkyl and Rbis Cis alkyl, In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkyl and Rbis C20 alkyl, In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkyl and Rbis C22 alkyl, In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkyl and Rbis C24 alkyl, In some embodiments, when R1is -CRbRc, then Rcis Cis alkyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cis alkyl and Rbis C22 alkyl.

[0133] In some embodiments, when R1is -CRbRc, then Rband Rcare C3 alkenyl. In some embodiments, when R1is -CRbRc, then Rband Rcare C4 alkenyl. In some embodiments, when R1is -CRbRc, then Rband Rcare C6alkenyl. In some embodiments, when R1is -CRbRc, then

[0134] Rband Rcare Cx alkenyl. In some embodiments, when R1is -CRbRc, then R1is -CRbRcand Rband Rcare C10 alkenyl. In some embodiments, when R1is -CRbRc, then R1is -CRbRcand Rband Rcare C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rband Rcare C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rband Rcare Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rband Rcare Cis alkenyl. In some embodiments, when

[0135] R1is -CRbRc, then Rband Rcare C20 alkenyl.

[0136] In some embodiments, when R1is -CRbRc, then Rbis Ci alkenyl and Rcis C5 alkenyl.

[0137] In some embodiments, when R1is -CRbRc, then Rbis Ci alkenyl and Rcis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C38 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C39 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C4 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis Cs alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis Cie alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C38 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C3 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C4 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis Cx alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C37 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis CY, alkenyl and Rcis Cx alkenyl. In some embodiments, when R1is -CRbRc, then RbC6alkenyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis Cie alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C34 alkenyl. In some embodiments, when R1is -CRbRc, then RbCx alkenyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cx alkenyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis Cie alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cis alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cis alkenyl and Rcis C22 alkenyl.

[0138] In some embodiments, when R1is -CRbRc, then Rcis Ci alkenyl and Rbis C5 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkenyl and Rbis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis Cs alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C38 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C39 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C4 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis Cx alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C38 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C3 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C4 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis Cx alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C37 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis Cs alkenyl. In some embodiments, when R1is -CRbRc, then RcC6alkenyl and Rbis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C34 alkenyl. In some embodiments, when R1is -CRbRc, then RcCs alkenyl and Rbis C 10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cx alkenyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis Cie alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C16 alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cis alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cis alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C5 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis Cs alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C38 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C39 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C4 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis Cs alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis Cis alkenyl, In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C20 alkenyl, In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkyl and Rcis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkyl and Rcis C36alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkyl and Rcis C38 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and RcIS C3alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and RcIS C4alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and Rcis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and RcIS C8alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then RbC6alkyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Ce alkyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6 alkyl and R is Cis alkenyl. In some embodiments, when R is -CRbRc, then Rbis C6alkyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C?x alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Ce alkyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Ce alkyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Q> alkyl and Rcis C34 alkenyl. In some embodiments, when R1is -CRbRc, then RbCx alkyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cx alkyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C24 alkenyl.

[0139] In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis Cu alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis Cu alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkyl and Rcis C16 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis CM alkyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cis alkyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cis alkyl and Rcis C22 alkenyl.

[0140] In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C5 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C8alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C16 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C18 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C38 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C39 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C4 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis Ci> alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis Cs alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2alkyl and Rbis Cio alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2alkyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2alkyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2alkyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2alkyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2alkyl and Rbis C2o alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2alkyl and Rbis C22alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2alkyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2alkyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2alkyl and Rbis C2s alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2alkyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2alkyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2alkyl and Rbis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2alkyl and Rbis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2alkyl and Rbis C38 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C3 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C4 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis Cs alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis Cio alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C2o alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3alkyl and Rbis C22alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3alkyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C--2alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3alkyl and Rbis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3alkyl and Rbis C37 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis Cs alkenyl. In some embodiments, when R1is -CRbRc, then RcC6alkyl and Rbis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis Cie alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C is alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis

[0141] C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C24 alkenyl.

[0142] In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C34 alkenyl. In some embodiments, when R1is -CRbRc, then RcCs alkyl and Rbis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis Cie alkenyl. In some embodiments, when R1is -CRbRc, then Rcis

[0143] Cs alkyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis

[0144] C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C24 alkenyl.

[0145] In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis Cie alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C26 alkenyl. In some embodiments, when R1-CRbRc, then Rcis Cio alkyl and RbC28 alkenyl. In some embodiments, when R1-CRbRc, then Rcis Cio alkyl and RbC30 alkenyl. In some embodiments, when R1-CRbRc, then Rcis C12 alkyl and C14 alkenyl. In some embodiments, when R1-CRbRc, then Rcis C12 alkyl and Ci6 alkenyl. In some embodiments, when R1-CRbRc, then Rcis C12 alkyl and Cis alkenyl. In some embodiments, when R1-CRbRc, then Rcis C12 alkyl and C20 alkenyl. In some embodiments, when R1-CRbRc, then Rcis C12 alkyl and C22 alkenyl. In some embodiments, when R1-CRbRc, then Rcis C12 alkyl and C24 alkenyl. In some embodiments, when R1-CRbRc, then Rcis C12 alkyl and C26 alkenyl. In some embodiments, when R1-CRbRc, then Rcis C12 alkyl and C28 alkenyl. In some embodiments, when R1-CRbRc, then Rcis C14 alkyl and Ci6 alkenyl. In some embodiments, when R1-CRbRc, then Rcis C14 alkyl and Cis alkenyl. In some embodiments, when R1-CRbRc, then Rcis C14 alkyl and C20 alkenyl. In some embodiments, when R1-CRbRc, then Rcis C14 alkyl and C22 alkenyl. In some embodiments, when R1-CRbRc, then Rcis C14 alkyl and Rbis C24 alkenyl. In some embodiments, when R1-CRbRc, then Rcis C14 alkyl and Rbis C26 alkenyl. In some embodiments, when R1-CRbRc, then Rcis Ci6 alkyl and Rbis Cis alkenyl. In some embodiments, when R1-CRbRc, then Rcis Ci6 alkyl and Rbis C20 alkenyl. In some embodiments, when R1-CRbRc, then Rcis Ci6 alkyl and Rbis C22 alkenyl. In some embodiments, when R1-CRbRc, then Rcis Ci6 alkyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cis alkyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cis alkyl and Rbis C22 alkenyl.

[0146] In some embodiments, when R1is -CRbRc, then Rbis Ci alkenyland Rcis C5 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C6alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis Cs alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis Cio alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then RbC1alkenyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis alkenyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then RbC1alkenyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then RbC1alkenyl and Rcis C32alkyl. In some embodiments, when R1is -CRbRc, then Rbis alkenyl and Rcis C34 alkyl. In some embodiments, when R1is -CRbRc, then RbIS C1alkenyl and Rcis C36 alkyl. In some embodiments, when R1is -CRbRc, then RbC1alkenyl and Rcis C38 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C39 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C4alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C6alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and R‘ is C8alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis Ci2alkyl. In some embodiments, when R1is -CRbRc, then RbIS C2alkenyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C18 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C22alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C24alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C38 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C3alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C4alkyl. In some embodiments, when R1is -CRbRc, then Rbis alkenyl and Rcis C6alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C8 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C36alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C37 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis Cs alkyl. In some embodiments, when R1is -CRbRc, then RbC6alkenyl and Rcis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rbis alkenyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C24 alkyl.

[0147] In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C34 alkyl. In some embodiments, when R1is -CRbRc, then RbCs alkenyl and Rcis C 10 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkenyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkenyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkenyl and Rcis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkenyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkenyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkenyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkenyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkenyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cio alkenyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis Ci8 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkenyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkenyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkenyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cis alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cis alkenyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkenyl and Rbis C5 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C6alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis Cs alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and RbC10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and RbC12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and RbC14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and RbCi6 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and RbCis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and RbC20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and RbC22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and RbC24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and RbC26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and RbC28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and RbC30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and RbC32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and RbC34 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and RbC36 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and RbC38 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C39 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C4 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C6alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis Cs alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C38 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C3 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C4 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C6alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis Cs alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C37 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis Cs alkyl. In some embodiments, when R1is -CRbRc, then RcC6alkenyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then R is C6alkenyl and R is Cie alkyl. In some embodiments, when R is -CRbRc, then Rcis C6alkenyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ce alkenyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ce alkenyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Q> alkenyl and Rbis C34 alkyl. In some embodiments, when R1is -CRbRc, then RcCs alkenyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then R is Cs alkenyl and R is Ci6 alkyl. In some embodiments, when R is -CRbRc, then Rcis Cs alkenyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C24 alkyl.

[0148] In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C12 alkyl. In some embodiments, Rcis C10 alkenyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then R is C10 alkenyl and R is Ci6 alkyl. In some embodiments, when R is -CRbRc, then Rcis C10 alkenyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis

[0149] C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C26 alkyl.

[0150] In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis CM alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkenyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkenyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cis alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cis alkenyl and Rbis C22 alkyl.

[0151] In some embodiments, R1is -C3H7, -C4H9, -C5H11, -C6Hn, -C7H15, -CsHu, -C10H21, -

[0152] C11H23, -C12H25, -C13H27, -C14H29, -C15H31, -C16H33, -C17H35, -C18H36, -C19H39, -C20H41, -

[0153] C21H43, -C22H45, -C23H47, -C24H49, -C25H50, -C3H6, -C4H8, -C5H10, -C6Hi2, -C7H14, -CgHie, - C10H20, -C11H21, -C12H24, -C13H26, -C14H28, -C15H30, -C16H32, -C17H34, -C18H35, -C19H38, - C20H40, -C21H42, -C22H44, -C23H46, -C24H48, or C25H50. In some embodiments, R2is a linear C3-C25 alkyl or C3-C25 cycloalkyl. In some embodiments, R2is a linear C3-C25 alkynyl or C3- C25 cycloalkynyl. In some embodiments, R2is a linear C3-C25 alkenyl or C3-C25 cycloalkenyl. In some embodiments, R2is a branched -C40 alkyl. C In6some embodiments, R2is a branched C6-C40 alkenyl. For example, in some embodiments of Formula n, R2has the following structures:

[0154] In some embodiments of Formula II, R1and R2are the same, in some embodiments, R1and R2are different.

[0155] In some embodiments of Formula II, R1is a linear or cyclic alkyl, alkenyl, or alkynyl consisting of 3 to 25 carbons, or a branched alkyl or alkenyl consisting of 6 to 40 carbons and R2is -CRbRc. In some embodiments of Formula II, R1is a linear or cyclic alkyl, alkenyl, or alkynyl consisting of 3 to 25 carbons and R2is -CRbRc. In some embodiments of Formula II, R1is a branched alkyl or alkenyl consisting of 6 to 40 carbons and R2is -CRbRc. In some embodiments of Formula II, R1is a linear or cyclic alkyl, alkenyl, or alkynyl consisting of 3 to 25 carbons, or a branched alkyl or alkenyl consisting of 6 to 40 carbons and R2is -CRbRc. In some embodiments of Formula II, R2is a linear or cyclic alkyl, alkenyl, or alkynyl consisting of 3 to 25 carbons, or a branched alkyl or alkenyl consisting of 6 to 40 carbons and R1is - CRbRc. In some embodiments of Formula II, R2is a linear or cyclic alkyl, alkenyl, or alkynyl consisting of 3 to 25 carbons and R1is -CRbRc. In some embodiments of Formula II, R2is a branched alkyl or alkenyl consisting of 6 to 40 carbons and R1is -CRbRc. In some embodiments of Formula II, R2is a linear or cyclic alkyl, alkenyl, or alkynyl consisting of 3 to 25 carbons, or a branched alkyl or alkenyl consisting of 6 to 40 carbons and R1is -CRbRc.

[0156] In some embodiments of Formula II, R1and R2are each independently -CRbRc. In some embodiments of Formula II, R1and R2are the same -CRbRc. In some embodiments of Formula II, R1and R2are the different -CRbRc.

[0157] In some embodiments of Formula II, R2is -CRbRc. In some embodiments, when R2is -CRbRc, then Rband Rcare C3 alkyl. In some embodiments, when R2is -CRbRc, then Rband Rcare C4 alkyl. In some embodiments, when R2is -CRbRc, then Rband Rcare C6alkyl. In some embodiments, when R2is -CRbRc, then Rband Rcare Cs alkyl. In some embodiments, when R2is -CRbRc, then Rband Rcare C10 alkyl. In some embodiments, when R2is -CRbRc, then Rband Rcare C12 alkyl. In some embodiments, when R2is -CRbRc, then Rband Rcare C14 alkyl. In some embodiments, when R2is -CRbRc, then Rband Rcare Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rband Rcare Cis alkyl. In some embodiments, when R2is -CRbRc, then Rband Rcare C20 alkyl.

[0158] In some embodiments, when R2is -CRbRc, then Rbis Ci alkyl and Rcis C5 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C6alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci alkyl and Rcis Cs alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci alkyl and Rcis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci alkyl and Rcis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci alkyl and Rcis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci alkyl and Rcis Cie alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci alkyl and Rcis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci alkyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci alkyl and Rcis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci alkyl and Rcis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci alkyl and Rcis C28 alkyl. In some embodiments, Rbis Ci alkyl and Rcis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci alkyl and Rcis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C34 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci alkyl and Rcis C36 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci alkyl and Rcis C38 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci alkyl and Rcis C39 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C4 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C6alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis Cx alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C14 alkyl. In some embodiments, Rbis C2 alkyl and Rcis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C34 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C36 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C38 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C3 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C4 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C6alkyl. In some embodiments, when R2is - CRbRc, then Rbis C3 alkyl and Rcis Cs alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis Cie alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ca alkyl and Rcis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C34 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C36 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C37 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis Cx alkyl. In some embodiments, when R2is - CRbRc, then RbC6alkyl and Rcis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis Cie alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C24 alkyl. In some embodiments, when R2is - CRbRc, then Rbis C6alkyl and Rcis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C34 alkyl. In some embodiments, when R2is -CRbRc, then RbCs alkyl and Rcis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkyl and Rcis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkyl and Rcis C14 alkyl. In some embodiments, when R2is - CRbRc, then Rbis Cs alkyl and Rcis Cie alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkyl and Rcis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkyl and Rcis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkyl and Rcis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkyl and Rcis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkyl and Rcis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkyl and Rcis C30 alkyl. In some embodiments, when R2is - CRbRc, then Rbis Cs alkyl and Rcis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkyl and Rcis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkyl and Rcis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkyl and Rcis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkyl and Rcis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkyl and Rcis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cio alkyl and Rcis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cio alkyl and Rcis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cio alkyl and Rcis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cio alkyl and Rcis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkyl and Rcis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkyl and Rcis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkyl and Rcis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkyl and Rcis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkyl and Rcis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkyl and Rcis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkyl and Rcis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkyl and Rcis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkyl and Rcis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cu alkyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cu alkyl and Rcis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkyl and Rcis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkyl and Rcis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci6 alkyl and Rcis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci6 alkyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci6 alkyl and Rcis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci6 alkyl and Rcis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cis alkyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cis alkyl and Rcis C22 alkyl.

[0159] In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis C5 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C6alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis Cx alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis Cio alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis C34 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis C36 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C38 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis C39 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C4 alkyl. In some embodiments, when R1is - CRbRc, then Rcis C2 alkyl and Rbis C6alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis Cs alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C34 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C36 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C38 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C3 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C4 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis G, alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis Cs alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C34 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C36 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C37 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis Cs alkyl. In some embodiments, when R2is -CRbRc, then RcC6alkyl and Rbis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis Cie alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis C28 alkyl. In some embodiments, when R2is - CRbRc, then Rcis C6alkyl and Rbis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis C34 alkyl. In some embodiments, when R2is -CRbRc, then RcCs alkyl and Rbis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis Cie alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis Cis alkyl. In some embodiments, when R2is - CRbRc, then Rcis Cs alkyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkyl and Rbis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkyl and Rbis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkyl and Rbis C16 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cio alkyl and Rbis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cio alkyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cio alkyl and Rbis

[0160] C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cio alkyl and Rbis C24 alkyl.

[0161] In some embodiments, when R2is -CRbRc, then Rcis Cio alkyl and Rbis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cio alkyl and Rbis C28alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cio alkyl and Rbis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkyl and Rbis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkyl and Rbis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkyl and Rbis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkyl and Rbis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkyl and Rbis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkyl and Rbis C26alkyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkyl and Rbis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkyl and Rbis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkyl and Rbis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkyl and Rbis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkyl and Rbis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkyl and Rbis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci6 alkyl and Rbis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci6 alkyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci6 alkyl and Rbis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci6 alkyl and Rbis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cis alkyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cis alkyl and Rbis C22 alkyl.

[0162] In some embodiments, when R2is -CRbRc, then Rband Rcare C3 alkenyl. In some embodiments, when R2is -CRbRc, then Rband Rcare C4 alkenyl. In some embodiments, when R2is -CRbRc, then Rband Rcare C6alkenyl. In some embodiments, when R2is -CRbRc, then

[0163] Rband Rcare Cx alkenyl. In some embodiments, when R2is -CRbRc, then R1is -CRbRcand Rband Rcare Cio alkenyl. In some embodiments, when R2is -CRbRc, then R1is -CRbRcand Rband Rcare C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rband Rcare C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rband Rcare C16 alkenyl. In some embodiments, when R2is -CRbRc, then Rband Rcare Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rband Rcare C20 alkenyl.

[0164] In some embodiments, when R2is -CRbRc, then Rbis Ci alkenyl and Rcis C5 alkenyl.

[0165] In some embodiments, when R2is -CRbRc, then Rbis Ci alkenyl and Rcis C6alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis Cx alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C34 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C36 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C38 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C39 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis C4 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis C6alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis Cx alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis C34 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis C36 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis C38 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C3 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C4 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C<> alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis Cx alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis Cie alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C34 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C36 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C37 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis Cs alkenyl. In some embodiments, when R2is -CRbRc, then RbC6alkenyl and Rcis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis Cie alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C34 alkenyl. In some embodiments, when R2is -CRbRc, then RbCx alkenyl and Rcis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkenyl and Rcis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cx alkenyl and Rcis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cx alkenyl and Rcis Cie alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkenyl and Rcis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkenyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkenyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkenyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkenyl and Rcis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkenyl and Rcis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkenyl and Rcis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkenyl and Rcis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkenyl and Rcis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkenyl and Rcis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkenyl and Rcis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkenyl and Rcis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkenyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkenyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkenyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkenyl and Rcis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkenyl and Rcis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkenyl and Rcis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkenyl and Rcis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkenyl and Rcis C16 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkenyl and Rcis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkenyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkenyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkenyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkenyl and Rcis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkenyl and Rcis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkenyl and Rcis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkenyl and Rcis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkenyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkenyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkenyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkenyl and Rcis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Ci6 alkenyl and Rcis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Ci6 alkenyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Ci6 alkenyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Ci6 alkenyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cis alkenyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cis alkenyl and Rcis C22 alkenyl.

[0166] In some embodiments, when R2is -CRbRc, then Rcis Ci alkenyl and Rbis C5 alkenyl.

[0167] In some embodiments, when R2is -CRbRc, then Rcis Ci alkenyl and Rbis C6alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis Cs alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C34 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C36 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C38 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C39 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C4 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C6alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis Cs alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C34 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C36 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C38 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C3 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C4 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis CV, alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis Cs alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C34 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C36 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C37 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis Cs alkenyl. In some embodiments, when R2is -CRbRc, then RcC6alkenyl and Rbis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C34 alkenyl. In some embodiments, when R2is -CRbRc, then RcCs alkenyl and Rbis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cx alkenyl and Rbis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cx alkenyl and Rbis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkenyl and Rbis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkenyl and Rbis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cio alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cio alkenyl and Rbis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cio alkenyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cio alkenyl and Rbis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cio alkenyl and Rbis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cio alkenyl and Rbis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cio alkenyl and Rbis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cio alkenyl and Rbis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkenyl and Rbis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkenyl and Rbis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkenyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkenyl and Rbis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkenyl and Rbis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkenyl and Rbis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkenyl and Rbis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkenyl and Rbis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkenyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkenyl and Rbis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkenyl and Rbis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkenyl and Rbis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Ci6 alkenyl and Rbis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Ci6 alkenyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Ci6 alkenyl and Rbis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Ci6 alkenyl and Rbis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cis alkenyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cis alkenyl and Rbis C22 alkenyl.

[0168] In some embodiments, when R2is -CRbRc, then Rbis Ci alkyl and Rcis C5 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C6alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis Cs alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis Cio alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C34 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C36 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C38 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkyl and Rcis C39 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C4 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis Ce alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis Cs alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis Ci8 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C34 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C36 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkyl and Rcis C38 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C3 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C4 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C6alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis Cs alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C34 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C36 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkyl and Rcis C37 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis Cs alkenyl. In some embodiments, when R2is -CRbRc, then RbC6alkyl and Rcis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C14 alkenyl. In some embodiments, when R2is -CRbRc, then R is C6alkyl and R is Ci6 alkenyl. In some embodiments, when R is -CRbRc, then Rbis C6alkyl and Rcis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C24 alkenyl.

[0169] In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkyl and Rcis C34 alkenyl. In some embodiments, when R2is -CRbRc, then RbCs alkyl and Rcis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkyl and Rcis C12 alkenyl. In some embodiments, when R2 is -CRbRc, then Rbis Cs alkyl and Rcis C14 alkenyl. In some embodiments, when R2is -CRbRc, then R is Cs alkyl and R is Ci6 alkenyl. In some embodiments, when R is -CRbRc, then Rbis Cx alkyl and Rcis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cx alkyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkyl and Rcis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkyl and Rcis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkyl and Rcis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cs alkyl and Rcis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkyl and Rcis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkyl and Rcis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkyl and Rcis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkyl and Rcis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkyl and Rcis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkyl and Rcis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkyl and Rcis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkyl and Rcis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkyl and Rcis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkyl and Rcis Ci8 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkyl and Rcis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkyl and Rcis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkyl and Rcis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkyl and Rcis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis C 14 alkyl and Rcis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Ci6 alkyl and Rcis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Ci6 alkyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Ci6 alkyl and Rcis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Ci6 alkyl and Rcis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cis alkyl and Rcis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rbis Cis alkyl and Rcis C22 alkenyl.

[0170] In some embodiments, when R2is -CRbRc, then Rcis Ci alkyl and Rbis C5 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C6alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis Cs alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C34 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C36 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C38 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkyl and Rbis C39 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C4 alkenyl, In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C6alkenyl, In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis Cs alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C34 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C36 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkyl and Rbis C38 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C3 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C4 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis Ce alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis Cs alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C34 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C36 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkyl and Rbis C37 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis Cs alkenyl. In some embodiments, when R2is -CRbRc, then RcC6alkyl and Rbis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis Cu alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Ce alkyl and Rbis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Ce alkyl and Rbis

[0171] C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis C24 alkenyl.

[0172] In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Ce alkyl and Rbis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkyl and Rbis C34 alkenyl. In some embodiments, when R2is -CRbRc, then RcCs alkyl and Rbis C10 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and R is Cis alkenyl. In some embodiments, when R is -CRbRc, then Rcis Cs alkyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis

[0173] C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis C24 alkenyl.

[0174] In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkyl and Rbis C32 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkyl and Rbis C12 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkyl and Rbis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkyl and Rbis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkyl and Rbis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkyl and Rbis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkyl and Rbis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkyl and Rbis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkyl and Rbis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkyl and Rbis C30 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkyl and Rbis C14 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkyl and Rbis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkyl and Rbis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkyl and Rbis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkyl and Rbis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkyl and Rbis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkyl and Rbis C28 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkyl and Rbis Ci6 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkyl and Rbis Cis alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkyl and Rbis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkyl and Rbis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis C 14 alkyl and Rbis C26 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Ci6 alkyl and Rbis Ci8 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Ci6 alkyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Ci6 alkyl and Rbis C22 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Ci6 alkyl and Rbis C24 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cis alkyl and Rbis C20 alkenyl. In some embodiments, when R2is -CRbRc, then Rcis Cis alkyl and Rbis C22 alkenyl.

[0175] In some embodiments, when R2is -CRbRc, then Rbis Ci alkenyland Rcis C5 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis G, alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis Cs alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C34 alkyl. In some embodiments, when R2-CRbRc, then Rbis alkenyl and Rcis C36 alkyl. In some embodiments, when R2is -CRbRc, then Rbis alkenyl and Rcis C38 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C1alkenyl and Rcis C39 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2alkenyl and Rcis C4alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2alkenyl and Rcis C6alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2alkenyl and R‘ is C8alkyl. In some embodiments, when R2-CRbRc, then Rbis C2alkenyl and Rcis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2alkenyl and Rcis C12 alkyl. In some embodiments, when R2-CRbRc, then Rbis C2alkenyl and Rcis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2alkenyl and Rcis Ci6 alkyl. In some embodiments, when R2-CRbRc, then Rbis C2alkenyl and Rcis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2alkenyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2alkenyl and Rcis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2 alkenyl and Rcis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2alkenyl and Rcis C26alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2alkenyl and Rcis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rbis alkenyl and Rcis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2alkenyl and Rcis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2alkenyl and Rcis C34 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2alkenyl and Rcis C36 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C2alkenyl and Rcis C38alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C3alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3alkenyl and is alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3alkenyl and Rcis C6alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3alkenyl and Rcis C8alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3alkenyl and Rcis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rbis alkenyl and Rcis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3alkenyl and Rcis C18 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3alkenyl and Rcis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C34 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C36 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C3 alkenyl and Rcis C37 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C8alkyl. In some embodiments, when R2is -CRbRc, then RbC6alkenyl and Rcis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C14 alkyl. In some embodiments, when R2is -CRbRc, then R is C6alkenyl and R is Cie alkyl. In some embodiments, when R is -CRbRc, then Rbis C6alkenyl and Rcis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis

[0176] C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C24 alkyl.

[0177] In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C6alkenyl and Rcis C34 alkyl. In some embodiments, when R2is -CRbRc, then RbCs alkenyl and Rcis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C8alkenyl and Rcis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C8alkenyl and Rcis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C8alkenyl and Rcis Cie alkyl. In some embodiments, when R2is -CRbRc, then Rbis C8alkenyl and Rcis Ci8alkyl. In some embodiments, when R2is -CRbRc, then Rbis C8alkenyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C8alkenyl and Rcis

[0178] C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cx alkenyl and Rcis C24 alkyl.

[0179] In some embodiments, when R2is -CRbRc, then Rbis C8alkenyl and Rcis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C8alkenyl and Rcis C28alkyl. In some embodiments, when R2is -CRbRc, then Rbis C8alkenyl and Rcis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C8alkenyl and Rcis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkenyl and Rcis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C10 alkenyl and Rcis Cu alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cio alkenyl and Rcis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cio alkenyl and Rcis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cio alkenyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cio alkenyl and Rcis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cio alkenyl and Rcis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cio alkenyl and Rcis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cio alkenyl and Rcis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cio alkenyl and Rcis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkenyl and Rcis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkenyl and Rcis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkenyl and Rcis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkenyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkenyl and Rcis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkenyl and Rcis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkenyl and Rcis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C12 alkenyl and Rcis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rbis CM alkenyl and Rcis Cie alkyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkenyl and Rcis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkenyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkenyl and Rcis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C14 alkenyl and Rcis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rbis C 1 alkenyl and Rcis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci6 alkenyl and Rcis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci6 alkenyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci6 alkenyl and Rcis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Ci6 alkenyl and Rcis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cis alkenyl and Rcis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rbis Cis alkenyl and Rcis C22 alkyl.

[0180] In some embodiments, when R2is -CRbRc, then Rcis Ci alkenyl and Rbis C5 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C6alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis Cs alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis Cio alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis CM alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C34 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C36 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C38 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C1alkenyl and Rbis C39 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C4 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C6alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis Cs alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C34 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C36 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C2 alkenyl and Rbis C38 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C3 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C4 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C6alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis Cs alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C 14 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C34 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C36 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C3 alkenyl and Rbis C37 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis Cs alkyl. In some embodiments, when R2is -CRbRc, then RcC6alkenyl and Rbis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C12 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis Cie alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C24 alkyl.

[0181] In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C6alkenyl and Rbis C34 alkyl. In some embodiments, when R2is -CRbRc, then RcCs alkenyl and Rbis C10 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis C12 alkyl. In some embodiments, when R2 is -CRbRc, then Rcis Cs alkenyl and Rbis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rcis

[0182] Cs alkenyl and Rbis C18 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cs alkenyl and Rbis C32 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkenyl and Rbis C12 alkyl. In some embodiments, Rcis C10 alkenyl and Rbis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkenyl and Rbis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkenyl and Rbis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkenyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkenyl and Rbis

[0183] C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkenyl and Rbis C24 alkyl.

[0184] In some embodiments, when R2is -CRbRc, then Rcis C10 alkenyl and Rbis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkenyl and Rbis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C10 alkenyl and Rbis C30 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkenyl and Rbis C14 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkenyl and Rbis Cie alkyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkenyl and Rbis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkenyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkenyl and Rbis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkenyl and Rbis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkenyl and Rbis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C12 alkenyl and Rbis C28 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkenyl and Rbis Ci6 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkenyl and Rbis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkenyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkenyl and Rbis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkenyl and Rbis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C14 alkenyl and Rbis C26 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C16 alkenyl and Rbis Cis alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci6 alkenyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Ci6 alkenyl and Rbis C22 alkyl. In some embodiments, when R2is -CRbRc, then Rcis C16 alkenyl and Rbis C24 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cis alkenyl and Rbis C20 alkyl. In some embodiments, when R2is -CRbRc, then Rcis Cis alkenyl and Rbis C22 alkyl.

[0185] In some embodiments, R2is -C6Hn, -C7H15, -CsHn, -C10H21, -C11H23, -C12H25, -C13H27,

[0186] -C14H29, -C15H31, -C16H33, -C17H35, -C18H36, -C19H39, -C20H41, -C21H43, -C22H45, -C23H47, - C24H49, -C6H12, -C7H14, -C8H16, -C10H20, -C11H21, -C12H24, -C13H26, -C14H28, -C15H30, -C16H32, -C17H34, -C18H35, -C19H38, -C20H40, -C21H42, -C22H44, -C23H46, or -C24H48. In some embodiments, the lipid compound of Formula II is selected from: or any combination thereof.

[0187] Described herein are compounds of Formula III: Formula III or a pharmaceutically acceptable salt thereof, wherein:

[0188] Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independently 0, 1, 2, 3 or 4; x and y are independently an integer from 1 to 15;

[0189] R1is independently for each occurrence a linear or cyclic alkyl, alkenyl , or alkynyl comprising of 3 to 25 carbons, or a branched alkyl or alkenyl comprising of 6 to 40 carbons; and

[0190] In some embodiments, the compound of Formula III is defined by one of formulae Illa-IIIf: or a pharmaceutically acceptable salt thereof, wherein:

[0191] Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independently 0, 1, 2, 3 or 4; m, x, and, y are independently an integer from 1 to 15; R1is independently for each occurrence linear or cyclic alkyl, alkenyl, or alkynyl comprising of 3 to 25 carbons, or a branched alkyl or alkenyl comprising of 6 to 40 carbons; and In some embodiments, the compound of Formula III, the lipid compound has structure Illa. In some embodiments, the lipid compound is a compound of formula Illb. In some embodiments, the lipid compound is a compound of formula IIIc. In some embodiments, the lipid compound is a compound of Hid. In some embodiments, the lipid compound is a compound of formula Hie. In some embodiments, the lipid compound is a compound of formula Illf.

[0192] In some embodiments, R1is a linear C3-C25 alkyl or cycloalkyl. In some embodiments, R1is a linear C3-C25 alkynyl or cycloalkynyl. In some embodiments, R1is a linear C3-C25 alkenyl or cycloalkenyl. In some embodiments, R1is a branched -C40 alkyl. ICn6some embodiments, R1is a branched C-C640 alkenyl. For example, in some embodiments, R1has the following structures: In some embodiments, the lipid compound of Formula III is selected from:

[0193]

[0194] Formula IV or a pharmaceutically acceptable salt thereof, wherein:

[0195]

[0196] Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independently 0, 1, 2, 3 or 4; m, x, and y are independently an integer from 1 to 15;

[0197] R1is independently for each occurrence linear or cyclic alkyl, alkenyl, or alkynyl comprising of 3 to 25 carbons, or a branched alkyl or alkenyl comprising of 6 to 40 carbons; and

[0198] L is selected from

[0199] In some embodiments, the compound of Formula IV is defined by one of formulae

[0200] IVa-IVe:

[0201] IVd IVe or a pharmaceutically acceptable salt thereof, wherein: Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independently 0, 1, 2, 3 or 4; m, x, and y are independently an integer from 1 to 15;

[0202] R1is independently for each occurrence linear or cyclic alkyl, alkenyl, or alkynyl comprising of 3 to 25 carbons, or a branched alkyl or alkenyl comprising of 6 to 40 carbons; and

[0203] L is selected from

[0204] In some embodiments, the compound of Formula IV is a compound of formula Iva. In some embodiments, the lipid compound is a compound of formula IVb. In some embodiments, the lipid compound is a compound of formula IVc. In some embodiments, the lipid compound is a compound of formula IVd. In some embodiments, the lipid compound is a compound of formula IVe.

[0205] In some embodiments, R1is a linear C3-C25 alkyl or cycloalkyl. In some embodiments, R1is a linear C3-C25 alkynyl or cycloalkynyl. In some embodiments, R1is a linear C3-C25 alkenyl or cycloalkenyl. In some embodiments, R1is a branched -C40 alkyl. In C6some embodiments, R1is a branched -C40 alkenCyl6. For example, in some embodiments, R1has the following structures:

[0206] In some embodiments, the lipid compound of Formula IV is selected from:

[0207]

[0208] Described herein are compounds of Formula V :

[0209] Formula V or a pharmaceutically acceptable salt thereof, wherein:

[0210]

[0211] Rais H, C1-C6alkyl or C1-C6alkenyl;

[0212] Rbis H, C1-C6alkyl or C1-C6alkenyl; i, j, k, p, q, and r are independently 0, 1, 2, 3 or 4; m, x, y, and z are independently an integer from 1 to 15;

[0213] R1is independently for each occurrence linear or cyclic alkyl, alkenyl, or alkynyl comprising of 3 to 25 carbons, or a branched alkyl or alkenyl comprising of 6 to 40 carbons; and

[0214] In some embodiments, R4is absent. In some embodiments, R4is -S-S-.

[0215] In some embodiments, Rais a H, C1-C6alkyl or C1-C6alkenyl. In some embodiments, Rais a H. In some embodiments, Rais a C1-C6alkyl. In some embodiments, Rais a C1-C6alkenyl.

[0216] In some embodiments, the compound of Formula V is selected from: Described herein are compounds of Formula VI: or a pharmaceutically acceptable salt thereof, wherein:

[0217] R5is -S-S-;

[0218] Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independently 0, 1, 2, 3 or 4; m, x, and y are independently an integer from 1 to 15; R1is independently for each occurrence linear or cyclic alkyl, alkenyl, or alkynyl comprising of 3 to 25 carbons, or a branched alkyl or alkenyl comprising of 6 to 40 carbons; and

[0219]

[0220] In some embodiments, the compound of Formula VI is selected from: combination thereof. In some embodiments of Formula I, II, III, IV, V, and VI, Rbis a H. In some embodiments of Formula I, II, III, IV, V, and VI, Rbis a C1-C6alkyl. In some embodiments of Formula I, II, III, IV, V, and VI, Rbis a C1-C6alkenyl.

[0221] In some embodiments of Formula I, II, III, IV, V, and VI, R1is -CRbRc. In some embodiments, when R1is -CRbRc, then Rband Rcare C3 alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare C4 alkyl. In some embodiments, when R1is -CRbRc, then Rb and Rcare C6alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare Cx alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare Cio alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare C12 alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare C14 alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare Cis alkyl. In some embodiments, when R1is -CRbRc, then Rband Rcare C20 alkyl.

[0222] In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C5 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C6alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis Cx alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis Cio alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, Rbis Ci alkyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C38 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C39 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C4 alkyl. In some embodiments, when R1is - CRbRc, then Rbis C2 alkyl and Rcis C6alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis Cs alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis Cio alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C14 alkyl. In some embodiments, Rbis C2 alkyl and Rcis Cie alkyl. In some embodiments, when R1is - CRbRc, then Rbis C2 alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C38 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C3 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C4 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C6alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis Cx alkyl. In some embodiments, when R1is - CRbRc, then Rbis C3 alkyl and Rcis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C37 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis Cx alkyl. In some embodiments, when R1is - CRbRc, then RbC6alkyl and Rcis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C24 alkyl. In some embodiments, when R1is - CRbRc, then Rbis C6alkyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ce alkyl and Rcis C34 alkyl. In some embodiments, when R1is -CRbRc, then RbCs alkyl and Rcis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C14 alkyl. In some embodiments, when R1is - CRbRc, then Rbis Cs alkyl and Rcis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkyl and Rcis C30 alkyl. In some embodiments, when R1is - CRbRc, then Rbis Cs alkyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and

[0223] Rcis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cu alkyl and Rcis C16 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cu alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cis alkyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cis alkyl and Rcis C22 alkyl.

[0224] In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C5 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis Ce alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis Cs alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis Ci6 alkyl, when R1is -CRbRc, then In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C38 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis C39 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C4 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C6alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis Cs alkyl. In some embodiments, when R1is - CRbRc, then Rcis C2 alkyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C38 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C3 alkyl. In some embodiments, when R1is - CRbRc, then Rcis C3 alkyl and Rbis C4 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C6alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis Cs alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C37 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis Cs alkyl. In some embodiments, when R1is -CRbRc, then RcC6alkyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis Cis alkyl. In some embodiments, when R1is - CRbRc, then Rcis C6alkyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ce alkyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C34 alkyl. In some embodiments, when R1is - CRbRc, then RcCs alkyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C24 alkyl. In some embodiments, when R1is - CRbRc, then Rcis Cs alkyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Rbis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cu alkyl and Rbis C16 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cis alkyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cis alkyl and Rbis C22 alkyl.

[0225] In some embodiments, when R1is -CRbRc, then Rband Rcare C3 alkenyl. In some embodiments, when R1is -CRbRc, then Rband Rcare C4 alkenyl. In some embodiments, when R1is -CRbRc, then Rband Rcare C6alkenyl. In some embodiments, when R1is -CRbRc, then

[0226] Rband Rcare Cx alkenyl. In some embodiments, when R1is -CRbRc, then R1is -CRbRcand Rband Rcare C10 alkenyl. In some embodiments, when R1is -CRbRc, then R1is -CRbRcand Rband Rcare C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rband Rcare C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rband Rcare Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rband Rcare Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rband Rcare C20 alkenyl.

[0227] In some embodiments, when R1is -CRbRc, then Rbis Ci alkenyl and Rcis C5 alkenyl.

[0228] In some embodiments, when R1is -CRbRc, then Rbis Ci alkenyl and Rcis Ce alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis Cx alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C38 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C39 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C4 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis Cx alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkenyl and Rcis C38 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C3 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C4 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis Cx alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C37 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis Cs alkenyl. In some embodiments, when R1is -CRbRc, then RbC6alkenyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis Cie alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C34 alkenyl. In some embodiments, when R1is -CRbRc, then RbCs alkenyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis Cie alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkenyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C16 alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkenyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cis alkenyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cis alkenyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Ci alkenyl and Rbis C5 alkenyl.

[0229] In some embodiments, when R1is -CRbRc, then Rcis Ci alkenyl and Rbis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis Cs alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C38 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C39 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C4 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis Cs alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis Cie alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C38 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C3 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C4 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis Cx alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C37 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis Cs alkenyl. In some embodiments, when R1is -CRbRc, then RcC6alkenyl and Rbis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis Cie alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C34 alkenyl. In some embodiments, when R1is -CRbRc, then RcCx alkenyl and Rbis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cx alkenyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cx alkenyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkenyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkenyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkenyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cis alkenyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cis alkenyl and Rbis C22 alkenyl.

[0230] In some embodiments, when R1is -CRbRc, then Rbis Ci alkyl and Rcis C5 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis Cs alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C38 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkyl and Rcis C39 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C4 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C6alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis Cs alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2 alkyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkyl and is C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkyl and Rcis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkyl and Rcis C36alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkyl and is C38 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and RcIS C3alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and Rcis C4alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and RcIS C6alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C8alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and is C12 alkenyl. In some embodiments, when R1is -CRbRc, then RbIS C3alkyl and RcIS C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then is C3alkyl and Rcis C34 alkenyl. In some embodiments, when R1is -CRbRc, then is C3alkyl and Rcis C36alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkyl and Rcis C37 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis Cs alkenyl. In some embodiments, when R1is -CRbRc, then RbC6alkyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis Cie alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C28alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C3o alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkyl and Rcis C34 alkenyl. In some embodiments, when R1is -CRbRc, then RbC8alkyl and Rcis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C8alkyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C8alkyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C8alkyl and Rcis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C8alkyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C8alkyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C8alkyl and Rcis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C8alkyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C8alkyl and Rcis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C8alkyl and Rcis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C8alkyl and Rcis C3o alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C8alkyl and Rcis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C16 alkenyl. some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkyl and Rcis C22 alkenyl. In some embodiments, when R1-CRbRc, then Rbis Cio alkyl and Rcis C24 alkenyl. In some embodiments, when R1-CRbRc, then Rbis Cio alkyl and Rcis C26 alkenyl. In some embodiments, when R1-CRbRc, then Rbis Cio alkyl and Rcis C28 alkenyl. In some embodiments, when R1-CRbRc, then Rbis Cio alkyl and Rcis C30 alkenyl. In some embodiments, when R1-CRbRc, then Rbis C12 alkyl and Rcis CM alkenyl. In some embodiments, when R1-CRbRc, then Rbis C12 alkyl and Rcis Ci6 alkenyl. In some embodiments, when R1-CRbRc, then Rbis C12 alkyl and Rcis Cis alkenyl. In some embodiments, when R1-CRbRc, then Rbis C12 alkyl and Rcis C20 alkenyl. In some embodiments, when R1-CRbRc, then Rbis C12 alkyl and Rcis C22 alkenyl. In some embodiments, when R1-CRbRc, then Rbis C12 alkyl and Rcis C24 alkenyl. In some embodiments, when R1-CRbRc, then Rbis C12 alkyl and Rcis C26 alkenyl. In some embodiments, when R1-CRbRc, then Rbis C12 alkyl and Rcis C28 alkenyl. In some embodiments, when R1-CRbRc, then Rbis CM alkyl and Rcis Ci6 alkenyl. In some embodiments, when R1-CRbRc, then Rbis CM alkyl and Rcis Cis alkenyl. In some embodiments, when R1-CRbRc, then Rbis C14 alkyl and Rcis C20 alkenyl. In some embodiments, when R1-CRbRc, then Rbis CM alkyl and Rcis C22 alkenyl. In some embodiments, when R1-CRbRc, then Rbis CM alkyl and Rcis C24 alkenyl. In some embodiments, when R1-CRbRc, then Rbis C14 alkyl and Rcis C26 alkenyl. In some embodiments, when R1-CRbRc, then Rbis Ci6 alkyl and Rcis Cis alkenyl. In some embodiments, when R1-CRbRc, then Rbis Ci6 alkyl and Rcis C20 alkenyl. In some embodiments, when R1-CRbRc, then Rbis Ci6 alkyl and Rcis C22 alkenyl. In some embodiments, when R1-CRbRc, then Rbis Ci6 alkyl and Rcis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cis alkyl and Rcis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rbis Cis alkyl and Rcis C22 alkenyl.

[0231] In some embodiments, when R1is -CRbRc, then Rcis Ci alkyl and Rbis Cs alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis Ce alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis Cs alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis Cio alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C38 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkyl and Rbis C39 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C4 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C<> alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis Cs alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2alkyl and Rbis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkyl and Rbis C38 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C3 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C4 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis G, alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis Cs alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3alkyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C16 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C34 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C36 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkyl and Rbis C37 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis Cs alkenyl. In some embodiments, when R1is -CRbRc, then RcC6alkyl and Rbis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C14 alkenyl. In some embodiments, when R1is -CRbRc, then R is C6alkyl and R is Cie alkenyl. In some embodiments, when R is -CRbRc, then Rcis C6alkyl and Rbis Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C24 alkenyl.

[0232] In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkyl and Rbis C34 alkenyl. In some embodiments, when R1is -CRbRc, then RcCs alkyl and Rbis C10 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C12 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis Cu alkenyl. In some embodiments, when R1is -CRbRc, then R is Cs alkyl and R is Cie alkenyl. In some embodiments, when R is -CRbRc, then Rcis Cs alkyl and Rbis C is alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C;, alkyl and Rbis C24 alkenyl.

[0233] In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkyl and Rbis C32 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C12 alkenyl, In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C14 alkenyl, In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis Ci6 alkenyl, In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis Cis alkenyl, In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C20 alkenyl, In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C22 alkenyl, In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C24 alkenyl, In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and Rbis C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkyl and C30 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and C14 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and C26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkyl and C28 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and Ci6 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and Cis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and C22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkyl and RbC26 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkyl and RbCis alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkyl and C20 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkyl and RbC22 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkyl and Rbis C24 alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cis alkyl and Rbis C2o alkenyl. In some embodiments, when R1is -CRbRc, then Rcis Cis alkyl and Rbis C22alkenyl.

[0234] In some embodiments, when R1is -CRbRc, then Rbis Ci alkenyland Rcis C5 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis Ci, alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis Cs alkyl. In some embodiments, when R1is -CRbRc, then RbC1alkenyl and Rcis Cio alkyl. In some embodiments, when R1is -CRbRc, then RbC1alkenyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then RbC1alkenyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C2o alkyl. In some embodiments, when R1is -CRbRc, then RbC1alkenyl and Rcis C22alkyl. In some embodiments, when R1is -CRbRc, then RbC1alkenyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then RbC1alkenyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then RbC1alkenyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then RbC1alkenyl and is C32alkyl. In some embodiments, when R1is -CRbRc, then Rbis alkenyl and Rcis C34 alkyl. In some embodiments, when R1is -CRbRc, then RbC1alkenyl and Rcis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C1alkenyl and Rcis C38 alkyl. In some embodiments, when R1is -CRbRc, then Rbis alkenyl and Rcis C39 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C4alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and is C6alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C8alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis Cio alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C12alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C16 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and RcIS Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C2o alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C22alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C36alkyl. In some embodiments, when R1is -CRbRc, then Rbis C2alkenyl and Rcis C38 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C3alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C4alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C6alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C8alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rbis alkenyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C18 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and is C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3alkenyl and Rcis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C3 alkenyl and Rcis C37 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C8alkyl. In some embodiments, when R1is -CRbRc, then RbC6alkenyl and Rcis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C24alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C6alkenyl and Rcis C34 alkyl. In some embodiments, when R1is -CRbRc, then RbCs alkenyl and Rcis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cx alkenyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis

[0235] C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C24 alkyl.

[0236] In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cs alkenyl and Rcis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C10 alkenyl and Rcis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C12 alkenyl and Rcis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rbis CM alkenyl and Rcis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis Ci8 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cu alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis C14 alkenyl and Rcis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkenyl and Rcis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkenyl and Rcis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Ci6 alkenyl and Rcis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cis alkenyl and Rcis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rbis Cis alkenyl and Rcis C22 alkyl.

[0237] In some embodiments, when R1is -CRbRc, then Rcis Ci alkenyl and Rbis C5 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C6alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis Cs alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C38 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C1alkenyl and Rbis C39 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C4 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C6alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis Cs alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C2 alkenyl and Rbis C38 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C3 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C4 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C6alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis Cs alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3 alkenyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3alkenyl and Rbis C34 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3alkenyl and Rbis C36 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C3alkenyl and Rbis C37 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C8alkyl. In some embodiments, when R1is -CRbRc, then RcC6alkenyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis Ci8alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C28alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C32alkyl. In some embodiments, when R1is -CRbRc, then Rcis C6alkenyl and Rbis C34 alkyl. In some embodiments, when R1is -CRbRc, then RcC8alkenyl and Rbis C10 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C8alkenyl and Rbis C12 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cs alkenyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then R is Cs alkenyl and R is Ci6 alkyl. In some embodiments, when R is -CRbRc, then Rcis C8alkenyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C8alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C8alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C8alkenyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C8alkenyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C8alkenyl and Rbis C28alkyl. In some embodiments, when R1is -CRbRc, then Rcis C8alkenyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C8alkenyl and Rbis C32 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C12 alkyl. In some embodiments, Rcis C10 alkenyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C16 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis Ci8alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C10 alkenyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cio alkenyl and Rbis C26 alkyl.

[0238] In some embodiments, when R1is -CRbRc, then Rcis Cio alkenyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cio alkenyl and Rbis C30 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C 12 alkenyl and Rbis C14 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C 12 alkenyl and Rbis Cie alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C 12 alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C 12 alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C12 alkenyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C 12 alkenyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C 12 alkenyl and Rbis C28 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C 14 alkenyl and Rbis Ci6 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C 14 alkenyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C 14 alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C 14 alkenyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C14 alkenyl and Rbis C26 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C 16 alkenyl and Rbis Cis alkyl. In some embodiments, when R1is -CRbRc, then Rcis C 16 alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Ci6 alkenyl and Rbis C22 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C 16 alkenyl and Rbis C24 alkyl. In some embodiments, when R1is -CRbRc, then Rcis C is alkenyl and Rbis C20 alkyl. In some embodiments, when R1is -CRbRc, then Rcis Cis alkenyl and Rbis C22 alkyl.

[0239] In some embodiments, R1is -C3H7, -C4H9, -C5H11, -C6Hi3, -C7H15, -CsHn, -C10H21, -

[0240] C11H23, -C12H25, -C13H27, -C14H29, -C15H31, -C16H33, -C17H35, -C18H36, -C19H39, -C20H41, - C21H43, -C22H45, -C23H47, -C24H49, -C25H50, -C3H6, -C4H8, -C5H10, -C6Hn, -C7H14, -CsHie, - C10H20, -C11H21, -C12H24, -C13H26, -C14H28, -C15H30, -C16H32, -C17H34, -C18H35, -C19H38, - C20H40, -C21H42, -C22H44, -C23H46, -C24H48, or C25H50.

[0241] In some embodiments, p, q, and r are independently 0, 1, 2, 3 or 4. In some embodiments, p is 0, 1, 2, 3 or 4. In some embodiments, q is 0, 1, 2, 3 or 4. In some embodiments, r is 0, 1, 2, 3 or 4. In some embodiments, p is 0, q is 0, and r is 0. In some embodiments, p is 0, q is 1, and r is 0. In some embodiments, p is 0, q is 1, and r is 1. In some embodiments, p is 0, q is 1, and r is 2. In some embodiments, p is 0, q is 1, and r is 3. In some embodiments, p is 0, q is 1, and r is 4. In some embodiments, p is 0, q is 2, and r is 3. In some embodiments, p is 0, q is 2, and r is 1. In some embodiments, p is 0, q is 2, and r is 2. In some embodiments, p is 0, q is 2, and r is 3. In some embodiments, p is 0, q is 2, and r is 4. In some embodiments, p is 0, q is 3, and r is 0. In some embodiments, p is 0, q is 3, and r is 1. In some embodiments, p is 0, q is 3, and r is 2. In some embodiments, p is 0, q is 3, and r is 3. In some embodiments, p is 0, q is 3, and r is 4. In some embodiments, p is 0, q is 4, and r is 0. In some embodiments, p is 0, q is 4, and r is 1. In some embodiments, p is 0, q is 4, and r is 2. In some embodiments, p is 0, q is 4, and r is 3. In some embodiments, p is 0, q is 4, and r is 4. In some embodiments, p is 1, q is 0, and r is 0. In some embodiments, p is 1, q is 1 , and r is 0. In some embodiments, p is 1, q is 1, and r is 1. In some embodiments, p is 1, q is 1 , and r is 2. In some embodiments, p is 1, q is 1, and r is 3. In some embodiments, p is 1, q is 1 , and r is 4. In some embodiments, p is 2, q is 1, and r is 1. In some embodiments, p is 2, q is 1 , and r is 2. In some embodiments, p is 2, q is 1, and r is 3. In some embodiments, p is 2, q is 1 , and r is 4. In some embodiments, p is 3, q is 1, and r is 1. In some embodiments, p is 3, q is 1 , and r is 2. In some embodiments, p is 3, q is 1, and r is 3. In some embodiments, p is 3, q is 1 , and r is 4. In some embodiments, p is 4, q is 1, and r is 1. In some embodiments, p is 4, q is 1 , and r is 2. In some embodiments, p is 4, q is 1, and r is 3. In some embodiments, p is 4, q is 1 , and r is 4. In some embodiments, p is 1, q is 2, and r is 0. In some embodiments, p is 1, q is 2, and r is 1. In some embodiments, p is 1, q is 2, and r is 2. In some embodiments, p is 1, q is 2, and r is 3. In some embodiments, p is 1, q is 2, and r is 4. In some embodiments, p is 1, q is 3, and r is 0. In some embodiments, p is 1, q is 3, and r is 1. In some embodiments, p is 1 , q is 3, and r is 2. In some embodiments, p is 1, q is 3, and r is 3. In some embodiments, p is 1 , q is 3, and r is 4. In some embodiments, p is 2, q is 4, and r is 0. In some embodiments, p is 2, q is 4, and r is 1. In some embodiments, p is 2, q is 4, and r is 2. In some embodiments, p is 2, q is 4, and r is 3. In some embodiments, p is 2, q is 4, and r is 4. In some embodiments, p is 3, q is 2, and r is 0. In some embodiments, p is 3, q is 2, and r is 1. In some embodiments, p is 3, q is 2, and r is 2. In some embodiments, p is 3, q is 2, and r is 3. In some embodiments, p is 3, q is 2, and r is 4. In some embodiments, p is 4, q is 3, and r is 0. In some embodiments, p is 4, q is 3, and r is 1. In some embodiments, p is 4, q is 3, and r is 2. In some embodiments, p is 4, q is 3, and r is 3. In some embodiments, p is 4, q is 3, and r is 4. In some embodiments, p is 4, q is 4, and r is 0. In some embodiments, p is 4, q is 4, and r is 1. In some embodiments, p is 4, q is 4, and r is 2. In some embodiments, p is 4, q is 4, and r is 3. In some embodiments, p is 4, q is 4, and r is 4. In some embodiments, p is 0 and q is 0. In some embodiments, p is 0 and q is 1. In some embodiments, p is 0 and q is 2. In some embodiments, p is 0 and q is 3. In some embodiments, p is 0 and q is 4. In some embodiments, p is 1 and q is 0. In some embodiments, p is 1 and q is

[0242] 1. In some embodiments, p is 1 and q is 2. In some embodiments, p is 1 and q is 3. In some embodiments, p is 1 and q is 4. In some embodiments, p is 2 and q is 0. In some embodiments, p is 2 and q is 1. In some embodiments, p is 2 and q is 2. In some embodiments, p is 2 and q is 3. In some embodiments, p is 2 and q is 4. In some embodiments, p is 3 and q is 0. In some embodiments, p is 3 and q is 1. In some embodiments, p is 3 and q is 2. In some embodiments, p is 3 and q is 3. In some embodiments, p is 3 and q is 4. In some embodiments, p is 4 and q is 0. In some embodiments, p is 4 and q is 1. In some embodiments, p is 4 and q is 2. In some embodiments, p is 4 and q is 3. In some embodiments, p is 4 and q is 4.

[0243] In some embodiments, i, j, and k are independently 0, 1 , 2, 3 or 4. In some embodiments, i is 0, 1, 2, 3 or 4. In some embodiments, j is 0, 1, 2, 3 or 4. In some embodiments, k is 0, 1, 2, 3 or 4. In some embodiments, i is 0, j is 0, and k is 0. In some embodiments, i is 0, j is 1, and k is 0. In some embodiments, i is 0, j is 1, and k is 1. In some embodiments, i is 0, j is 1, and k is

[0244] 2. In some embodiments, i is 0, j is 1, and k is 3. In some embodiments, i is 0, j is 1, and k is 4.

[0245] In some embodiments, i is 0, j is 2, and k is 0. In some embodiments, i is 0, j is 2, and k is 1. In some embodiments, i is 0, j is 2, and k is 2. In some embodiments, i is 0, j is 2, and k is 3. In some embodiments, i is 0, j is 2, and k is 4. In some embodiments, i is 0, j is 3, and k is 0. In some embodiments, i is 0, j is 3, and k is 1. In some embodiments, i is 0, j is 3, and k is 2. In some embodiments, i is 0, j is 3, and k is 3. In some embodiments, i is 0, j is 3, and k is 4. In some embodiments, i is 0, j is 4, and k is 0. In some embodiments, i is 0, j is 4, and k is 1. In some embodiments, i is 0, j is 4, and k is 2. In some embodiments, i is 0, j is 4, and k is 3. In some embodiments, i is 0, j is 4, and k is 4. In some embodiments, i is 1, j is 0, and k is 0. In some embodiments, i is 1, j is 1, and k is 0. In some embodiments, i is 1, j is 1, and k is 1. In some embodiments, i is 1, j is 1, and k is 2. In some embodiments, i is 1, j is 1, and k is 3. In some embodiments, i is 1, j is 1, and k is 4. In some embodiments, i is 2, j is 1, and k is 1. In some embodiments, i is 2, j is 1, and k is 2. In some embodiments, i is 2, j is 1, and k is 3. In some embodiments, i is 2, j is 1, and k is 4. In some embodiments, i is 3, j is 1, and k is 1. In some embodiments, i is 3, j is 1, and k is 2. In some embodiments, i is 3, j is 1, and k is 3. In some embodiments, i is 3, j is 1, and k is 4. In some embodiments, i is 4, j is 1, and k is 1. In some embodiments, i is 4, j is 1, and k is 2. In some embodiments, i is 4, j is 1, and k is 3. In some embodiments, i is 4, j is 1, and k is 4. In some embodiments, i is 1, j is 2, and k is 0. In some embodiments, i is 1, j is 2, and k is 1. In some embodiments, i is 1, j is 2, and k is 2.

[0246] In some embodiments, i is 1, j is 2, and k is 3. In some embodiments, i is 1, j is 2, and k is 4.

[0247] In some embodiments, i is 1, j is 3, and k is 0. In some embodiments, i is 1, j is 3, and k is 1.

[0248] In some embodiments, i is 1, j is 3, and k is 2. In some embodiments, i is 1, j is 3, and k is 3.

[0249] In some embodiments, i is 1, j is 3, and k is 4. In some embodiments, i is 2, j is 4, and k is 0.

[0250] In some embodiments, i is 2, j is 4, and k is 1. In some embodiments, i is 2, j is 4, and k is 2.

[0251] In some embodiments, i is 2, j is 4, and k is 3. In some embodiments, i is 2, j is 4, and k is 4.

[0252] In some embodiments, i is 3, j is 2, and k is 0. In some embodiments, i is 3, j is 2, and k is 1.

[0253] In some embodiments, i is 3, j is 2, and k is 2. In some embodiments, i is 3, j is 2, and k is 3.

[0254] In some embodiments, i is 3, j is 2, and k is 4. In some embodiments, i is 4, j is 3, and k is 0.

[0255] In some embodiments, i is 4, j is 3, and k is 1. In some embodiments, i is 4, j is 3, and k is 2.

[0256] In some embodiments, i is 4, j is 3, and k is 3. In some embodiments, i is 4, j is 3, and k is 4.

[0257] In some embodiments, i is 4, j is 4, and k is 0. In some embodiments, i is 4, j is 4, and k is 1.

[0258] In some embodiments, i is 4, j is 4, and k is 2. In some embodiments, i is 4, j is 4, and k is 3.

[0259] In some embodiments, i is 4, j is 4, and k is 4.

[0260] In some embodiments, j is 0 and k is 0. In some embodiments, j is 0 and k is 1. In some embodiments, j is 0 and k is 2. In some embodiments, j is 0 and k is 3. In some embodiments, j is 0 and k is 4. In some embodiments, j is 1 and k is 0. In some embodiments, j is 1 and k is 1. In some embodiments, j is 1 and k is 2. In some embodiments, j is 1 and k is 3. In some embodiments, j is 1 and k is 4. In some embodiments, j is 2 and k is 0. In some embodiments, j is 2 and k is 1. In some embodiments, j is 2 and k is 2. In some embodiments, j is 2 and k is 3. In some embodiments, j is 2 and k is 4. In some embodiments, j is 3 and k is 0. In some embodiments, j is 3 and k is 1. In some embodiments, j is 3 and k is 2. In some embodiments, j is 3 and k is 3. In some embodiments, j is 3 and k is 4. In some embodiments, j is 4 and k is 0. In some embodiments, j is 4 and k is 1. In some embodiments, j is 4 and k is 2. In some embodiments, j is 4 and k is 3. In some embodiments, j is 4 and k is 4.

[0261] In some embodiments, m, x, y, and z are independently integer 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15. In some embodiments, m, x, and y are independently integer from 1 to 15 (e.g., from 1 to 14, from 1 to 13, from 1 to 12, from 1 to 11, from 1 to 10, from 1 to 9, from 1 to 8, from 1 to 7, from 1 to 6, from 1 to 5, from 1 to 4, from 1 to 3, from 1 to 2, from 2 to 15, from 2 to 14, from 2 to 13, from 2 to 12, from 2 to 11, from 2 to 10, from 2 to 9, from 2 to 8, from 2 to 7, from 2 to 6, from 2 to 5, from 2 to 4, from 2 to 3, from 3 to 15, from 3 to 14, from 3 to 13, from 3 to 12, from 3 to 11, from 3 to 10, from 3 to 9, from 3 to 8, from 3 to 7, from 3 to 6, from 3 to 5, from 3 to 4, from 4 to 15, from 4 to 14, from 4 to 13, from 4 to 12, from 4 to 11, from 4 to 10, from 4 to 9, from 4 to 8, from 4 to 7, from 4 to 6, from 4 to 5, from 5 to 15, from 5 to 14, from 5 to 13, from 5 to 12, from 5 to 11, from 5 to 10, from 5 to 9, from 5 to 8, from 5 to 7, from 5 to 6, from 6 to 15, from 6 to 14, from 6 to 13, from 6 to 12, from 6 to 11, from 6 to 10, from 6 to 9, from 6 to 8, from 6 to 7, from 7 to 15, from 7 to 14, from 7 to 13, from 7 to 12, from 7 to 11, from 7 to 10, from 7 to 9, from 7 to 8, from 8 to 15, from 8 to 14, from 8 to 13, from 8 to 12, from 8 to 11, from 8 to 10, from 8 to 9, from 9 to 15, from 9 to 14, from 9 to 13, from 9 to 12, from 9 to 11, from 9 to 10, from 10 to 15, from 10 to

[0262] 14, from 10 to 13, from 10 to 12, from 10 to 11, from 11 to 15, from 11 to 14, from 11 to 13, from 11 to 12, from 12 to 15, from 12 to 14, from 12 to 13, from 13 to 14, from 13 to 15, or from 14 to 15).

[0263] Compositions

[0264] Described herein are compositions including a compound of Formula I, II, III, IV, V, VI, or any combination thereof and an active agent. The compositions can further include an excipient of some sort may be useful in a variety of medical and non- medical applications. For example, pharmaceutical compositions described herein may be useful in the delivery of an effective amount of an agent to a subject in need thereof. Compositions described herein may be useful for non-medical applications, e.g., such as an emulsion or emulsifier, useful, for example, as a food component, for extinguishing fires, for disinfecting surfaces, for oil cleanup, etc.

[0265] In some embodiments, the composition can be a lipid nanoparticle dispersion, a liposomal formulation, a lipid emulsion, or any combination thereof including a compound of Formula I, II, III, IV, V, VI, or any combination thereof.

[0266] In one aspect, the disclosure provides a composition including: a lipid nanoparticle, including a compound of Formula I, II, III, IV, V, VI, or any combination thereof; and an active agent.

[0267] In certain embodiments, the composition can include an agent, as described herein. For example, in certain embodiments, the agent is any chemical compound to be administered to a subject may be delivered using the particles or nanoparticles described herein. The agent may be an organic molecule (e.g., a therapeutic agent, a drug), inorganic molecule, small molecule, organometallic compound, metal, nucleic acid, protein, amino acid, peptide, polypeptide, polynucleotide, targeting agent, isotopically labeled organic or inorganic molecule, vaccine, immunological agent, or an agent useful in bioprocessing. In certain embodiments, the agent is a polynucleotide. In some embodiments, the agent includes an mRNA encoding at least one antigenic polypeptide or an immunogenic fragment thereof capable of inducing an immune response to the antigenic polypeptide.

[0268] In some embodiments, the mRNA encoding at least one antigenic polypeptide or an immunogenic fragment thereof capable of inducing an immune response to the antigenic polypeptide is encapsulated by the nanoparticle.

[0269] In some aspects, disclosed herein is a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a nanoparticle comprising a compound of Formula I, II, III, IV, V, VI, or any combination thereof; and an mRNA encoding at least one antigenic polypeptide or an immunogenic fragment thereof capable of inducing an immune response to the antigenic polypeptide.

[0270] Nanoparticles

[0271] Described herein are lipid nanoparticles including 20% to 80% of a compound described herein (e.g., a compound of Formula I, II, III, IV, V, VI, or any combination thereof); greater than 0 % to 5 % polyethylene glycol- lipid; greater than 0 % to 40 % helper lipids; 0 % to 80 % sterol; and an active agent encapsulated in the nanoparticle. In some embodiments, the lipid nanoparticle can further include a cationic lipid.

[0272] Described herein are also compositions including an effective amount of a lipid nanoparticle described herein and a carrier. In some embodiments, the carrier can be a pharmaceutically acceptable carrier.

[0273] In one aspect, described are nanoparticle including: a compound of Formula I, II, III, IV, V, VI, or any combination thereof; and optionally a helper lipid; a polyethylene glycollipid; a sterol, or any combination thereof; and an active agent encapsulated in the nanoparticle.

[0274] In one aspect, described are nanoparticle including: a compound of Formula I, II, III, IV, V, VI, or any combination thereof; and a helper lipid; a polyethylene glycol-lipid; and / or a sterol; and an active agent encapsulated in the nanoparticle.

[0275] In one aspect, described are nanoparticle including: a compound of Formula I, II, III, IV, V, VI, or any combination thereof; a helper lipid; a polyethylene glycol-lipid; and a sterol; and an active agent encapsulated in the nanoparticle. In one aspect, described are nanoparticle including: a compound of Formula I; and a helper lipid; a polyethylene glycol-lipid; and / or a sterol; and an active agent encapsulated in the nanoparticle.

[0276] In one aspect, described are nanoparticle including: a compound of Formula II; and a helper lipid; a polyethylene glycol-lipid; and / or a sterol; and an active agent encapsulated in the nanoparticle.

[0277] In one aspect, described are nanoparticle including: a compound of Formula III; and a helper lipid; a polyethylene glycol-lipid; and / or a sterol; and an active agent encapsulated in the nanoparticle.

[0278] In one aspect, the disclosure provides a nanoparticle comprising: a compound of Formula IV; and a helper lipid; a polyethylene glycol-lipid; and / or a sterol; and an active agent encapsulated in the nanoparticle.

[0279] The various compounds of Formula I, II, III, IV, V, and VI are described in the Compounds section above. In some embodiments, the nanoparticle comprises a compound of Formula I, II, III, IV, V, VI, or any combination thereof in a molar ratio of from 20% to 80%; and an active agent encapsulated in the nanoparticle.

[0280] In some embodiments, the nanoparticle comprises a helper lipid. In some embodiments, the helper lipid can be a non-cationic lipid. In some embodiments, the non-cationic lipid can include, but is not limited to, l,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), 1- palmitoyl-2-olcoyl-.77-glyccro-3-phosphoclhanolaminc (POPE), l,2-distearoyl-OT-glycero-3- phosphocholine (DSPC), l-stearoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (SOPE), 1,2- dipalmitoyl-sn-glycero-3- phosphocholine (DPPC), l,2-dioleyl-sn-glycero-3- phosphotidylcholine (DOPC), l,2-dipalmitoyl-sn-glycero-3 -phosphoethanolamine (DPPE), l,2-dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE), l,2-Dimyristoyl-sn-glycero-3- phosphorylcholine (DMPC), l,2-dioleoyl-5 / 7-glycero-3- phospho-(l'-rac-glycerol) (DOPG), 1- Palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (PLPC), 1 -Palmitoyl-2-oleoyl-sn- glycero-3-phosphocholine (POPC). l-Stearoyl-2-myristoyl-sn-glycero-3-phosphocholine (SMPC), or combinations thereof. In one embodiment, the non-cationic lipid is 1 ,2-dioleoyl- OT-glycero-3-phosphoethanolamine (DOPE). In one embodiment, the non-cationic lipid is 1- palmitoyl-2-oleoyl-,n-glycero-3-phosphoethanolamine (POPE), In one embodiment, the noncationic lipid is 1 .2-distearoyl-.sn-glyccro-3 -phosphocholine (DSPC). In one embodiment, the non-cationic lipid is l-stearoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (SOPE). While several non-cationic lipids are described here, additional non-cationic lipids can be used in combination with the compounds disclosed herein.

[0281] In some embodiments, the helper lipid can be present in a molar ratio of at least 0%, (e.g., at least 5%, at least 10%, at least 20%, at least 30%, or at least 40%). In some embodiments, the helper lipid can be present in a molar ratio of 40% or less, (e.g., 30% or less, 20% or less, 10% or less, 5% or less, 1% or less, or 0.5% or less).

[0282] The helper lipid can be present in a molar ratio ranging from any of the minimum values described above to any of the maximum values described above. For example, in some embodiments, the helper lipid can be present in a molar ratio of from 0% to 40% (e.g., from greater than 0% to 30%, from greater than 0% to 20%, from greater than 0% to 10%, from greater than 0% to 5%, from greater than 0% to 1%, from greater than 0% to 0.5%, from 1% to 30%, from 1% to 20%, from 1% to 10%, from 1% to 5%, from 5% to 30%, from 5% to 20%, from 5% to 10%, from 10% to 30%, from 10% to 20%, from 20% to 30%, from 20% to 40%, or from 30% to 40%).

[0283] In some embodiments, the nanoparticle includes a polyethylene glycol-lipid (PEG- lipid). PEG-lipid is incorporated to form a hydrophilic outer layer and stabilize the particles. Nonlimiting examples of polyethylene glycol-lipids include PEG-modified lipids such as PEG- modified phosphatidylethanolamines, PEG-modified phosphatidic acids, PEG-modified ceramides, PEG- modified dialkylamines, PEG-modified diacylglycerols, and PEG-modified dialkylglycerols. Representative polyethylene glycol-lipids include DMG-PEG, DLPE-PEGs, DMPE-PEGs, DPPC-PEGs, and DSPE-PEGs. In one embodiment, the polyethylene glycollipid is 1,2-dimyristoyl-sn-glycerol, methoxypolyethylene glycol (DMG-PEG). In one embodiment, the polyethylene glycol-lipid is 1,2-dimyristoyl-sn-glycerol, methoxypolyethylene glycol-2000 (DMG-PEG2000). DMG-PEGXXXX means 1,2- dimyristoyl-sn-glycerol, methoxypolyethylene glycol-XXXX, wherein XXXX signifies the molecular weight of the polyethylene glycol moiety, e.g. DMG-PEG2000 or DMG-PEG5000.

[0284] In some embodiments, the lipid nanoparticle can further include a cationic lipid. Suitable cationic lipid can include, but not limited to, l,2-dioleoyl-3-trimethylammonium propane (DOTAP), l,2-di-O-octadecenyl-3-trimethylammonium propane (DOTMA), dimethyldimyristylammonium, N-hexadecyl-N,N-dimethylhexadecan- 1 -aminium, N-(2- hydroxyethyl)-N,N-dimethyl-2,3-bis(oleoyloxy)propan-l-aminium (DORI), N-(4- carboxybenzyl)-N,N-dimethyl-2,3-bis(oleoyloxy)propan-l-aminium (DOBAQ). In some embodiments, the polyethylene glycol-lipid can be present in a molar ratio of at least 0%, (e.g., at least 0.25%, at least 0.5%, at least 0.75%, at least 1%, at least 1.5%, at least 2%, at least 3%, at least 4%, or at least 5%). In some embodiments, the polyethylene glycol-lipid can be present in a molar ratio of 5% or less, (e.g., 4% or less, 3% or less, 2% or less, 1% or less, or 0.5% or less).

[0285] The polyethylene glycol-lipid can be present in a molar ratio ranging from any of the minimum values described above to any of the maximum values described above. For example, in some embodiments, the polyethylene glycol-lipid can be present in a molar ratio of from 0% to 5% (e.g., from greater than 0% to 4%, from greater than 0% to 3%, from greater than 0% to 2%, from greater than 0% to 1%, from greater than 0% to 0.5%, from 1% to 5%, from 1% to 4%, from 1% to 3%, from 1% to 2%, from 2% to 5%, 2% to 4%, 2% to 3%, from 3% to 5%, from 3% to 4%, or 4% to 5%). In one embodiment, the polyethylene glycol-lipid in a molar ratio of 0.75%.

[0286] In some embodiments, the nanoparticle includes a sterol. Sterols are well known to those skilled in the art and generally refers to those compounds having a perhydrocyclopentanophenanthrene ring system and having one or more OH substituents. Examples of sterols include, but are not limited to, cholesterol, campesterol, ergosterol, sitosterol, and the like.

[0287] In some embodiments, the sterol is selected from a cholesterol-based lipid. In some embodiments, the one or more cholesterol-based lipids are selected from cholesterol, PEGylated cholesterol, DC-Choi (N,N-dimethyl-N-ethylcarboxamidocholesterol), l,4-bis(3- N-oleylamino-propyl)piperazine, or combinations thereof.

[0288] The sterol can be used to tune the particle permeability and fluidity base on its function in cell membranes. In one embodiment, the sterol is cholesterol.

[0289] In some embodiments, the sterol in a molar ratio of at least 0%, (e.g., at least 5%, at least 10%, at least 15%, at least 20%, at least 25%, at least 30%, at least 35%, at least 40%, at least 45%, at least 50%, at least 60%, at least 70%, or at least 80%). In some embodiments, the sterol in a molar ratio of 80% or less, (e.g., 70% or less, 60% or less, 50% or less, 40% or less, 30% or less, 20% or less, 10% or less, 5% or less, or 1% or less).

[0290] The sterol can be present in a molar ratio ranging from any of the minimum values described above to any of the maximum values described above. In some embodiments, the sterol can be present in a molar ratio of from 0% to 80%, (e.g., from greater than 0% to 70%, from greater than 0% to 60%, from greater than 0% to 50% from greater than 0% to 40%, from greater than 0% to 30%, from greater than 0% to 20%, from greater than 0% to 10%, from greater than 0% to 5%, from greater than 0% to 1%, from 5% to 70%, from 5% to 60%, from 5% to 50% from 5% to 40%, from 5% to 30%, from 5% to 20%, from 5% to 10%, from 10% to 70%, from 10% to 60%, from 10% to 50% from 10% to 40%, from 10% to 30%, from 10% to 20%, from 20% to 70%, from 20% to 60%, from 20% to 50%, from 20% to 40%, from 20% to 30%, from 30% to 70%, from 30% to 60%, from 30% to 50%, from 30% to 40%, from 40% to 70%, from 40% to 60%, from 40% to 50%, from 50% to 70%, from 50% to 60%, from 60% to 70% from 60% to 80%, from 70% to 80%, from 10% to 80%, from 20% to 80%, from 30% to 80%, from 40% to 80%, or from 50% to 80%. In some embodiment, the nanoparticle comprises a sterol in a molar ratio of 40%.

[0291] In some embodiments, the nanoparticle can include from 40% to 60% of a compound described herein; from 1% to 2% polyethylene glycol-lipid; from 8% to 12% helper lipids; from 35% to 40% sterol; and an active agent encapsulated in the nanoparticle.

[0292] In one embodiment, described are nanoparticles including 50% of a compound described herein; 1.5% polyethylene glycol-lipid; 10% helper lipids (e.g., DSPC); 38.5% sterol (e.g., cholesterol); and an active agent encapsulated in the nanoparticle.

[0293] In one embodiment, the disclosure provides a nanoparticle comprising: a compound of Formula I, II, III, IV, V, VI, or any combination thereof; and an active agent encapsulated in the nanoparticle.

[0294] In some embodiments, described are nanoparticles including: a compound of Formula I, II, III, IV, V, VI, or any combination thereof;

[0295] 1.2-dioleoyl-s«-glycero-3-phosphoethanolamine (DOPE);

[0296] 1.2-dimyristoyl-sn-glycerol, methoxypolyethylene glycol (DMG-PEG2000);

[0297] Beta-sitosterol; and an active agent encapsulated in the nanoparticle.

[0298] In one embodiment, the disclosure provides a nanoparticle comprising: a compound of Formula I, II, III, IV, V, VI, or any combination thereof; l-palmitoyl-2-oleoyl-5n-glycero-3-phosphoethanolamine (POPE);

[0299] 1,2-dimyristoyl-sn-glycerol, methoxypolyethylene glycol (DMG-PEG2...

Claims

CLAIMSWe claim:

1. A compound of Formula III:Formula III or a pharmaceutically acceptable salt thereof, wherein:Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independently 0, 1, 2, 3 or 4; m, x, and y are independently an integer from 1 to 15;R1is independently for each occurrence linear or cyclic alkyl, alkenyl , or alkynyl comprising from 3 to 25 carbons, or a branched alkyl or alkenyl comprising from 6 to 40 carbons; and2. The compound of claim 1, wherein the compound of Formula III is defined by one of formulae Illa-IIIf :or a pharmaceutically acceptable salt thereof, wherein:Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independently 0, 1, 2, 3 or 4; m, x, and y are independently an integer from 1 to 15;R1is independently for each occurrence linear or cyclic alkyl, alkenyl, or alkynyl comprising from 3 to 25 carbons, or a branched alkyl or alkenyl comprising from 6 to 40 carbons; and3. The compounds of claim 1 or claim 2, wherein the compound of Formula III is selected from:or a pharmaceutically acceptable salt thereof.

4. A compound of Formula I:Formula I or a pharmaceutically acceptable salt thereof, wherein:p, q, and r are independently 0, 1, 2, 3 or 4; x and y are independently an integer from 1 to 15;R1is independently for each occurrence linear or cyclic alkyl, alkenyl, or alkynyl comprising from 3 to 25 carbons, or a branched alkyl or alkenyl comprising from 6 to 40 carbons; and5. The compound of claim 4, wherein the compound of Formula I is defined by one of formulae la-Ig:pharmaceutically acceptable salt thereof,Ig wherein:Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independently 0, 1, 2, 3 or 4; x and y are independently an integer from 1 to 15;R1is independently for each occurrence linear or cyclic alkyl, alkenyl, or alkynyl comprising from 3 to 25 carbons, or branched alkyl or alkenyl comprising from 6 to 40 carbons; and6. The compounds of claim 4 or claim 5, wherein the compound of Formula I is selected from:Formula II or a pharmaceutically acceptable salt thereof, wherein:Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independently 0, 1, 2, 3 or 4; m, n, x, and y are independently an integer from 1 to 15;R1and R2are independently linear or cyclic alkyl, alkenyl, or alkynyl comprising from 3 to 25 carbons, or a branched alkyl or alkenyl comprising from 6 to 40 carbons; andThe compound of claim 7, wherein the compound of Formula II is defined by one of formulae Ila-IIe:lid lie or a pharmaceutically acceptable salt thereof, wherein:Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independently 0, 1, 2, 3 or 4; m, n, x, and y are independently an integer from 1 to 15;R1is linear or cyclic alkyl, alkenyl, or alkynyl comprising from 3 to 25 carbons, or branched alkyl or alkenyl comprising from 6 to 40 carbons;R2is linear or cyclic alkyl, alkenyl, or alkynyl comprising from 3 to 25 carbons, or branched alkyl or alkenyl comprising from 6 to 40 carbons; and9. The compounds of claim 7 or claim 8, wherein the compound of Formula II is selected from:Formula IV or a pharmaceutically acceptable salt thereof, wherein:Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independentlym, x, and y are independently an integer from 1 to 15;R1is independently linear or cyclic alkyl, alkenyl, or alkynyl comprising from 3 to 25 carbons, or branched alkyl or alkenyl comprising from 6 to 40 carbons; andL is selected from11. The compound of claim 1 , wherein the compound of Formula IV is defined by formulaeIVa-IVe:Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independently 0, 1, 2, 3 or 4; m, x, and y are independently an integer from 1 to 15;R1is linear or cyclic alkyl, alkenyl, or alkynyl comprising from 3 to 25 carbons, or branched alkyl or alkenyl comprising from 6 to 40 carbons; andL is selected from12. The compounds of claim 10 or claim 11, wherein the compound of Formula IV is selected from:pharmaceutically acceptable salts thereof.

13. A compound of Formula V:Formula V or a pharmaceutically acceptable salt thereof, wherein:R4is absent or -S-S-;Rais C1-C6alkyl or C1-C6alkenyl;Rbis H, C1-C6alkyl or C1-C6alkenyl; i, j, k, p, q, and r are independently 0, 1, 2, 3 or 4; m, x, y, and z are independently an integer from 1 to 15;R1is independently for each occurrence linear or cyclic alkyl, alkenyl, or alkynyl comprising from 3 to 25 carbons, or a branched alkyl or alkenyl comprising from 6 to 40 carbons; and14. The compounds of claim 13, wherein the compound of Formula V is selected from:

15. A compound of Formula VI:or a pharmaceutically acceptable salt thereof, wherein:R5is -S-S-;Rais C1-C6alkyl or C1-C6alkenyl;Rbis H, C1-C6alkyl or C1-C6alkenyl; p, q, and r are independently 0, 1, 2, 3 or 4; m, x, and y are independently an integer from 1 to 15;R1is linear or cyclic alkyl, alkenyl, or alkynyl comprising from 3 to 25 carbons, or branched alkyl or alkenyl comprising from 6 to 40 carbons; and16. The compounds of claim 15, wherein the compound of Formula VI is selected from:any combination thereof.

17. A composition comprising: a compound of formula I, II, III, IV, V, VI, or any combination thereof.

18. A composition comprising: a compound of any of claims 1-16; or a composition of claim 17; andan active agent.

19. The composition of claim 18, wherein the active agent is a diagnostic, prophylactic, or therapeutic agent.

20. The composition of claim 18 or claim 19, wherein the active agent is a nucleic acid, a protein / peptide, a small molecule, or any combination thereof.

21. The composition of claim 20, wherein the agent is a nucleic acid.

22. The composition of any one of claims 18-21, wherein the nucleic acid comprises double stranded DNA, single- stranded DNA, complexed DNA, encapsulated DNA, naked RNA, encapsulated RNA, messenger RNA (mRNA), tRNA, short interfering RNA (siRNA), double stranded RNA (dsRNA), micro-RNA (miRNA), antisense RNA (asRNA), selfamplify mRNA (saRNA), guide RNA (gRNA), cRNA, Cas mRNA, or any combination thereof.

23. The composition of any one of claims 18-22, wherein the nucleic acid comprises mRNA.

24. The composition of claim 23, wherein the mRNA encodes at least one Metapneumovirus (hMPV) antigenic polypeptide, parainfluenza viruses (hPIV) types 1, 2, and 3 (hPIVl, hPIV2 and hPIV3, respectively) antigenic polypeptide, respiratory syncytial virus (RSV) antigenic polypeptide, measles virus (MeV) antigenic polypeptide, varicellazoster antigenic polypeptide, influenza virus antigenic polypeptide, herpes simplex virus 1 (HSV1) antigenic polypeptide, herpes simplex virus 2 (HSV2) antigenic polypeptide, poxvirus (e.g., smallpox, monkeypox) antigenic polypeptide, African swine fever virus antigenic polypeptide, cytomegalovirus antigenic polypeptide, Epstein-Barr virus antigenic polypeptide, rotavirus antigenic polypeptide, rhinovirus antigenic polypeptide, adenovirus antigenic polypeptide, papillomavirus antigenic polypeptide, poliovirus antigenic polypeptide, mumps antigenic polypeptide, rabies antigenic polypeptide, rubella antigenic polypeptide, coxsackieviruses antigenic polypeptide, equine encephalitis antigenic polypeptide, Japanese encephalitis antigenic polypeptide, yellow fever antigenic polypeptide, Rift Valley fever antigenic polypeptide, hepatitis A, B, C, D, and E virusantigenic polypeptide, or coronaviruses (e.g., MERS-CoV, SARS-CoV, SARS-CoV2, HCoV-OC43, HCoV-229E, HCoV-NL63, HCoV-NL, HCoV-NH, HCoV-HKUl) antigenic polypeptide, or any combination thereof.

25. The composition of claim 23, wherein the mRNA encodes tumor antigen, cytokines (e.g., interferons, interleukins, colony stimulating factors), monoclonal antibodies, bispecific antibody, bispecific T cell engager, or antibody fragment (single chain fragment variable (scFv), fragment antigen binding ((Fab’)2), intrabody, nanobody), Cas-editing protein, or any combination thereof.

26. The composition of any one of claims 18-25, wherein the composition comprises a lipid nanoparticle dispersion, a liposomal formulation, a lipid emulsion, or any combination thereof.

27. A lipid nanoparticle comprising:20% to 80% of a compound of any of claims 1-16 or a composition of claim 17;0 % to 5 % pegylated lipids;0 % to 40 % helper lipids;0 % to 80 % sterol; and an active agent encapsulated in the nanoparticle.

28. The nanoparticle of claim 27, wherein the nanoparticle further comprises a cationic lipid.

29. The nanoparticle of claim 28, wherein the cationic lipid comprises l,2-dioleoyl-3- trimethylammonium propane (DOTAP), l,2-di-O-octadecenyl-3-trimethylammonium propane (DOTMA), dimethyldimyristylammonium, N-hexadecyl-N,N-dimethylhexadecan- 1-aminium, N-(2- hydroxyethyl)-N,N-dimethyl-2,3-bis(oleoyloxy)propan-l-aminium (DORI), N-(4- carboxybenzyl)-N,N-dimethyl-2,3-bis(oleoyloxy)propan- 1-aminium (DOBAQ).

30. The nanoparticle of claim 27, wherein the active agent comprises a nucleic acid, a protein / peptide, a small molecule, or any combination thereof.

31. The nanoparticle of claim 28, wherein the active agent is a nucleic acid.

32. The nanoparticle of claim 29, wherein the nucleic acid comprises double stranded DNA, single- stranded DNA, complexed DNA, encapsulated DNA, naked RNA, encapsulated RNA, messenger RNA (mRNA), tRNA, short interfering RNA (siRNA), double stranded RNA (dsRNA), micro-RNA (miRNA), antisense RNA (asRNA), self-amplify mRNA (saRNA), guide RNA (gRNA), cRNA, Cas mRNA, or any combination thereof.

33. The nanoparticle of claim 29 or claim 30, wherein the nucleic acid comprises mRNA.

34. The nanoparticle of claim 31, wherein the mRNA encodes tumor antigen, cytokines (e.g., interferons, interleukins, colony stimulating factors), monoclonal antibodies, or antibody fragment (single chain fragment variable (scFv), fragment antigen binding ((Fab’)2), intrabody, nanobody), Cas-editing protein, or any combination thereof.

35. The nanoparticle of claim 32, wherein the mRNA encodes at least one Metapneumovirus (hMPV) antigenic polypeptide, parainfluenza viruses (hPIV) types 1, 2, and 3 (hPIVl, hPIV2 and hPIV3, respectively) antigenic polypeptide, respiratory syncytial virus (RSV) antigenic polypeptide, measles virus (MeV) antigenic polypeptide, varicellazoster antigenic polypeptide, influenza virus antigenic polypeptide, herpes simplex virus 1 (HSV1) antigenic polypeptide, herpes simplex virus 2 (HSV2) antigenic polypeptide, poxvirus (e.g., smallpox, monkeypox) antigenic polypeptide, African swine fever virus antigenic polypeptide, cytomegalovirus antigenic polypeptide, Epstein-Barr virus antigenic polypeptide, rotavirus antigenic polypeptide, rhinovirus antigenic polypeptide, adenovirus antigenic polypeptide, papillomavirus antigenic polypeptide, poliovirus antigenic polypeptide, mumps antigenic polypeptide, rabies antigenic polypeptide, rubella antigenic polypeptide, coxsackieviruses antigenic polypeptide, equine encephalitis antigenic polypeptide, Japanese encephalitis antigenic polypeptide, yellow fever antigenic polypeptide, Rift Valley fever antigenic polypeptide, hepatitis A, B, C, D, and E virus antigenic polypeptide, or coronaviruses (e.g., MERS-CoV, SARS-CoV, SARS-CoV2, HCoV-OC43, HCoV-229E, HCoV-NL63, HCoV-NL, HCoV-NH, HCoV-HKUl) antigenic polypeptide, or any combination thereof.

36. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount of the lipid nanoparticle of any one of claims 27-33.

37. A method for delivering an active agent into a cell, comprising: introducing into the cell a composition of any one of claims 18-26 or a nanoparticle or any one of claims 27-33.

38. A method for treating or preventing an infection caused by an infection agent, the method comprising administering to a subject in need thereof a composition of any one of claims 18-26, a nanoparticle of any one of claims 27-33.

39. A method of inducing an immune response against an infection caused by an infection agent, the method comprising administering to a subject in need thereof a composition of any one of claims 18-26, a nanoparticle of any one of claims 27-33.

40. The method of claim 36 or claim 37, wherein the infection agent comprises bacterial organisms as Streptococccus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyrogenes, Corynebacterium diphtheriae, Listeria monocytogenes, Bacillus anthracis, Clostridium tetani, Clostridium botulinum, Clostridium perfringens, Neisseria meningitidis, Neisseria gonorrhoeae, Streptococcus mutans, Pseudomonas aeruginosa, Salmonella typhi, Haemophilus parainfluenzae, Bordetella pertussis, Francisella tularensis, Yersinia pestis, Vibrio cholerae, Legionella pneumophila, Mycobacterium tuberculosis, Mycobacterium leprae, Treponema pallidum, Leptospirosis interrogans, Borrelia burgdorferi, Camphylobacter jejuni, and the like; viruses such as Metapneumovirus such as human Metapneumovirus (hMPV), parainfluenza viruses such as human parainfluenza viruses (hPIV) types 1, 2, and 3 (hPIVl, hPIV2 and hPIV3, respectively), respiratory syncytial virus (RSV), measles virus (MeV), coronaviruses (e.g., MERS-CoV, SARS-CoV, SARS-CoV2, HCoV-OC43, HCoV-229E, HCoV-NL63, HCoV-NL, HCoV-NH, HCoV-HKUl), poxviruses (e.g., smallpox, monkeypox), African swine virus, influenza A and B, human immunodeficiency virus (HIV), varicella-zoster, herpes simplex 1 and 2, cytomegalovirus, Epstein-Barr virus, rotavirus, rhinovirus, adenovirus, papillomavirus, poliovirus, mumps, rabies, rubella, coxsackieviruses, equineencephalitis, Japanese encephalitis, yellow fever, Rift Valley fever, hepatitis A, B, C, D, and E virus, and the like; fungal, protozoan, and parasitic organisms such as Cryptococcus neoformans, Histoplasma capsulatum, Candida albicans, Candida tropicalis, Nocardia asteroides, Rickettsia ricketsii, Rickettsia typhi, Mycoplasma pneumoniae, Chlamydial psittaci, Chlamydial trachomatis, Plasmodium falciparum, Trypanosoma brucei, Entamoeba histolytica, Toxoplasma gondii, Trichomonas vaginalis, Schistosoma mansoni, and the like.

41. A method for treating or preventing a respiratory infection, the method comprising administering to a subject in need thereof a composition of any one of claims 18-26, a nanoparticle of any one of claims 27-33.

42. The method of any one of claims 36-39, wherein the subject is a veterinary patient.

43. The method of any one of claims 36-39, wherein the subject is a mammal.

44. The method of claim 41, wherein the mammal is a human.

45. The method of any one of claims 36-42, can be administered oral, topical, transcutaneous, transdermal, intra-joint, intra-arteriole, intradermal, intraventricular, intralesional, intranasal, rectal, vaginal, by inhalation, via an implanted reservoir, subcutaneous, intravenous, intramuscular, intra- articular, intra-synovial, intrasternal, intrathecal, intraperitoneal, intrahepatic, intralesional, intracranial injections or infusion techniques.

46. A method for delivering an active agent into a cell, comprising: introducing into the cell a composition of any one of claims 18-26 or a nanoparticle or any one of claims 27-33.

47. The method of claims 44, wherein the composition or nanoparticle comprises an active agent comprising a nucleic acid, a pro tein / pep tide, a small molecule, or any combination thereof.

48. The method of claims 45, wherein the active agent comprises a nucleic acid.

49. The method of any one of claims 44-46, comprising introducing a composition or nanoparticle comprising a nucleic acid into a specific cell or tissue to express a protein encoded by the nucleic acid to correct a defect caused by a deficiency in that nucleic acid in the cells or tissue.

50. The method of any one of claims 44-46, comprising introducing a composition or nanoparticle comprising a nucleic acid into a specific cell or tissue in vivo to express a protein encoded by the nucleic acid on the specific cell or tissue to induce immune responses by the subject.

51. The method of any one of claims 44-46, comprising introducing a composition or nanoparticle comprising a nucleic acid into a specific cell or tissue ex vivo to express a protein encoded by the nucleic acid on the specific cell or tissue generating a chimeric cell or tissue; and administering the chimeric cell or tissue to a subject.

52. The method of any one of claims 44-46, wherein the specific cell is a T-cell (e.g., CAR T cells) derived from a subject.

53. The method of any one of claims 44-46, wherein the method introduces a polynucleotide to regulate gene expression, protein expression, antibody expression or any combination thereof.

54. The method of any one of claims 44-47, wherein the method introduces a polynucleotide for cell reprogramming by modulating cell behavior.

55. The method of any one of claims 44-48, wherein the polynucleotide encodes for an intrabody, a bispecific antibody, and bispecific T cell engager (BiTE).

56. The method of any one of claims 44-48, comprising introducing a composition or nanoparticle comprising a nucleic acid into a specific cell or tissue to silence expression of a protein encoded by a nucleic acid to correct a defect caused by an overexpression of that nucleic acid in the cells or tissue.

57. The method of any one of claims 44-48, comprising introducing a composition or nanoparticle comprising a nucleic acid into a specific cell or tissue to silence expression of a protein encoded by a nucleic acid on the specific cell or tissue to induce immune responses by the subject.

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