A soap formulation for use in epidemic control and nosocomial infections and a preparation method thereof

Abstract

The invention relates to a bioecocomposite soap formulation for preventing chemical, biological, radiological and nuclear decontamination and nosocomial infections and to provide epidemic control, and to a preparation method thereof. The soap formulation of the invention contains plant-based raw materials, plant extracts and natural ingredients.

Description

[0001] DESCRIPTION

[0002] A SOAP FORMULATION FOR USE IN EPIDEMIC CONTROL AND NOSOCOMIAL INFECTIONS AND A PREPARATION METHOD THEREOF

[0003] Technical Field of the Invention

[0004] The invention relates to a bioecocomposite soap formulation for preventing chemical, biological, radiological and nuclear decontamination and nosocomial infections and to provide epidemic control, and to a preparation method thereof. The environmentally friendly soap formulation with antibacterial, antifungal and antiviral properties contains plant-based raw materials, plant extracts and natural ingredients.

[0005] State of the Art

[0006] Hospital-acquired infections (HAIs), also known as nosocomial infections, are also known as healthcare-associated infections as they are infections developed in patients recently receiving healthcare service and health care [1]. These infections usually develop during the hospital stay or shortly after the discharge and occur as a result of the contamination of microorganisms in a hospital flora in a hospital environment. In particular, the places where the nosocomial infections are most common are Intensive Care Units (ICU), and mechanical ventilators, central catheters, nasogastric and urinary catheters or other invasive interventions, widespread use of multiple antibiotics, together with diseases such as kidney, heart, liver failure, diabetes mellitus, create a suitable environment for the colonization of the resistant microorganisms and the development of an infection [2], Despite all the precautions, it is still one of the most important causes of mortality and morbidity increase all over the world, and it is becoming one of the important health problems in terms of prolonging the length of hospital stay and increasing the cost of treatment.

[0007] Due to the nosocomial infections, approximately 2 million people in the USA are infected with these infections every year, around 90,000 people die from these infections, and it costs five million dollars [3]. Therefore, the prevention of these infections is of great importance, and the prevention of the nosocomial infections primarily requires strategies such as nosocomial infection surveillance, hand hygiene, compliance with the rules of standard precautions and isolation measures, environment sanitation and disinfection, application of aseptic techniques, use of appropriate antibiotics, and compliance with sterilization-disinfection principles [4], because 30-40% of infections caused by hospital-acquired resistant microorganisms develop by the hands of hospital staff, 20-25% by unnecessary and inappropriate use of antibiotics, 20-25% by community-acquired infections, and 20% by undetected causes. Although it is known that compliance with hand hygiene is the easiest, cheapest and most effective method for the prevention of healthcare-associated infections, studies show that the rate of compliance with hand hygiene is between 30-60% or even does not exceed 50% [5]. To this end, even if the disinfectants are used, it is frequently encountered that hospital personnel do not scrub their hands thoroughly with alcohol-based hand disinfectants. Therefore, hand hygiene is provided by washing hands with a soap / antiseptic agent, or scrubbing them with a water-free alcohol-based hand antiseptic, to remove the temporary flora. For this, hands should be washed in accordance with the technique. Hands should be wetted under water, whereas the wrists, palms, and the back and interdigital of the hands should be foamed with a soap, together with the edges and tips of the nails and rubbed vigorously for at least 20 seconds, rinsed with water, dried with paper towels, and the tap should be closed with paper towels and the used towel should be thrown into a trash can. An effective washing process is achieved when the hands are washed in accordance with the technique [6].

[0008] Another factor that is effective for the spread of the nosocomial infections is the sanitation of the environment. Hospital surfaces, especially patient rooms, intensive care units and operating rooms, are regularly cleaned and disinfected for the chemical, biological, radiological and nuclear contamination, thus preventing the accumulation and spread of microorganisms on the surfaces. However, the products used for this purpose contain chemical residues, which may cause skin irritation or other health problems in some people. In addition, these chemical residues have negative environmental effects. In the state of the art, cleaners containing quaternary ammonium compounds, which are widely used in hospital surface sanitation, cause asthma, allergic reactions and skin sensitivity. In addition, the aforementioned chemical-containing cleaners may threaten the human health and the environment and cause serious toxic effects, in case they are used in a long term and high amounts. In addition, it should be noted that the chemical cleaning agents may sometimes not completely dissolve in water or leave residues on certain surfaces. This means that the sanitation process is not fully completed.

[0009] Due to the limitations and inabilities of the solutions in the state of the art, it has been necessary to make a development in the relevant field as the products used for hand washing against the nosocomial infections, as well as the cleaning agents used for the hospital surfaces, contain chemical residues, thus having negative effects on the human health and the environment, and the use of hand antiseptics cause skin irritation.

[0010] Summary and Objectives of the Invention

[0011] The invention discloses a bioecocomposite soap formulation for preventing chemical, biological, radiological and nuclear decontamination and nosocomial infections and providing epidemic control, and a preparation method thereof. The environmentally friendly soap formulation with antibacterial, antifungal and antiviral properties contains plant-based raw materials, plant extracts and natural ingredients.

[0012] The object of the invention is to provide a soap formulation for use in both surface and skin cleansing and sterilization. As the content of said bioecocomposite soap is completely based on plant extracts, its use is suitable for both surfaces and skin.

[0013] Another object of the invention is to provide a bioecocomposite soap formulation with antibacterial, antifungal and antiviral properties. Here, phenolic contents of the vegetative materials provide an antimicrobial effect.

[0014] Another object of the invention is to provide a soap formulation that is environmentally friendly and does not have a negative impact on human health.

[0015] An object of the invention is to provide an effective soap formulation against the resistant pathogens. Detailed Description of the Invention

[0016] The invention relates to a bioecocomposite soap formulation for preventing chemical, biological, radiological and nuclear decontamination and nosocomial infections and to provide epidemic control, and to a preparation method thereof. The environmentally friendly soap formulation with antibacterial, antifungal and antiviral properties contains plant-based raw materials, plant extracts and natural ingredients.

[0017] The bioecocomposite soap formulation according to the invention contains water, sodium hydroxide, olive oil and a plant extract. In an embodiment of the invention, the soap formulation of the invention contains 26.40-30.40% of water, 5.5-5.86% of sodium hydroxide, 26.40-30.40% of olive oil, and 36-39% of a plant extract. In another embodiment of the invention, the soap formulation of the invention contains 1 liter of water (kg), 0.2 kg of sodium hydroxide, 1 kg of olive oil, 1 .32 kg of a plant extract. Here, said plant extract includes willow leaves, walnut leaves, lemons, mints, cherry leaves, almond leaves, acacia leaves, tree-of-heaven leaves, pine needles, poplar leaves, grass, hyacinths, poppies, lilacs, yarrow, viper’s bugloss, felty germander, dandelion, lily, tea, or pennyroyal, each being in equal amounts.

[0018] Microorganisms for which the bioecocomposite of the invention is effective are E.coli, E.coli 0157, E.coli 026, E.coli 0104, Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Methicillin resistant S. aureus, Enterococcus f aecium, Enterococcus fecalis, Vancomycin resistant Enterococcus faecium, Streptococcus epidermidis, Listeria innocua, Listeria monocytogenes 1 / 2a, Listeria monocytogenes 1 / 2b, Listeria monocytogenes 3b, Salmonella Dublin, Salmonella Enteritidis, Salmonella, Typhimurium, Salmonella Infantis, Campylobacter jejuni, Campylobacter coli, Campylobacter lari, Geobacillus stearothemophilus, Shigella flexneri, Cronobacter sakazakii, Cronobacter muytjensii, Klebsiella pneumonia, Pseudomonas aeruginosa, Proteus mirabilis, Acinetobacter baumanii, Vibrio parahemolyticus, Yersinia enterocolitica.

[0019] A production method of a bioecocomposite soap formulation according to the invention for preventing nosocomial infections comprises the process steps of: i. drying the plants at 25-50°C, ii. grinding and pulverizing the dried plants using a ball mill, iii. depositing the plant powders in a box, iv. adding 190-210 grams of sodium hydroxide (NaOH) to 0.9-1.1 liters of water and thus preparing a NaOH solution of 4.31 -5.55 mol / liter and leaving the solution to stand until the temperature reaches 93-100°C, v. adding and stirring 0.90-1 .05 liters of olive oil to the NaOH solution of 5 mol / liter at 95°C, vi. upon a drop in the temperature of the mixture to the range of 50-60°C under the room conditions, adding the plant powders deposited in the box in the process step (iii) and stirring them again, vii. pouring the resulting mixture into molds and drying the same under the room conditions, in an area with no sunlight, viii. grating the dried material and adding thereto potable water up to 10-100 times its mass.

[0020] In another embodiment of the invention, a production method of a bioecocomposite soap formulation according to the invention for preventing nosocomial infections comprises the process steps of: i. drying the plants at 30°C, ii. grinding and pulverizing the dried plants using a ball mill, iii. depositing the plant powders in a box, iv. adding 200 grams of sodium hydroxide (NaOH) to 1 liters of water and thus preparing a NaOH solution of 5 mol / liter and leaving the solution to stand until the temperature reaches 95°C, v. adding and stirring 1 liters of olive oil to the NaOH solution of 5 mol / liter at 95°C, vi. upon a drop in the temperature of the mixture to the range of 57°C under the room conditions, adding the plant powders deposited in the box in the process step (iii) and stirring them again, vii. pouring the resulting mixture into molds and drying the same under the room conditions, in an area with no sunlight, viii. grating the dried material and adding thereto potable water up to 50 times its mass. Industrial Applicability of the Invention

[0021] The invention relates to a bioecocomposite soap formulation for preventing chemical, biological, radiological and nuclear decontamination and nosocomial infections and to provide epidemic control, and to a preparation method thereof, and has industrial applicability. Said bioecocomposite is applied to microorganisms or environments which cause epidemics or diseases by being sprayed with a spray, or by being applied in the form of a cream.

[0022] The invention is not limited to the foregoing exemplary explanations, and one person skilled in the art may easily reveal the different embodiments of the invention. These should be considered within the scope of protection of the invention claimed in the claims.

[0023] REFERENCES

[0024] [1] Hacimustafaoglu M, Qelebi S, Tuncer E, Ozkaya G, Qakir D, Bozdemir §E. Qocuk Klinigi ve Qocuk Yogun Bakim Unitesi Hastane Enfeksiyonlari Sikhgi. J Pediatr Inf 2009;3:1 12-7. http: / / www.cocukenfeksiyondergisi. org / upload / documents / 200903 / 1 12-

[0025] 1 17.pdf

[0026] [2] Ahsen Oncul, Safiye Kogulu, Keziban Elevli, “Bir Devlet Hastanesinin Yogun Bakim Unitelerinde Kazamlan Hastane Enfeksiyonlannm Epidemiyolojisi”, Qi§li Eftal Hastanesi Tip Bulteni, C. 46 S. 2, 2012, s. 60-66. [3] Macias A, Leon P. Infection Control: Old Problems and New Challenges. Archieves of Medical Research.2005; 36: 637-645.

[0027] [4] Akalm E. Saghk Hizmeti ili§kili infeksiyonlann Onlenmesinde Stratejik Yakla§imlar. Hastane infeksiyonlan Dergisi 2016;20(1):69-70

[0028] [5] Watson J. Role of multimodal educational strategy on healthcare workers hadwashing, American Journal of Infection Control. 2016; 44:400-4. 9.

[0029] [6] Gunaydm M. Hastane Enfeksiyonlari ve El Hijyeni. 24. DAS Egitim Semineri, Karamanoglu Mehmet Bey Universitesi Konferans Salonu, 2013. https: / / www.das.org.tr / dosya / mg / 24se miner.pdf Eri§im: 06.05.2019.

Claims

CLAIMS1. A bioecocomposite soap formulation for preventing chemical, biological, radiological, nuclear decontamination and hospital infections, characterized in that it comprises water, sodium hydroxide, olive oil and a plant extract.

2. A soap formulation according to claim 1 , characterized in that it contains, by mass, 26.40-30.40% of water, 5.5-5.86% of sodium hydroxide, 26.40-30.40% of olive oil, and 36-39% of a plant extract.

3. A soap formulation according to claim 1 , characterized in that it contains 1 liter of water (kg), 0.2 kg of sodium hydroxide, 1 kg of olive oil, and 1.32 kg of a plant extract.

4. A soap formulation according to any one of claims 1 -3, characterized in that said plant extract includes willow leaves, walnut leaves, lemons, mints, cherry leaves, almond leaves, acacia leaves, tree-of-heaven leaves, pine needles, poplar leaves, grass, hyacinths, poppies, lilacs, yarrow, viper’s bugloss, felty germander, dandelion, lily, tea, or pennyroyal, each being in equal amounts.

5. A production method of a bioecocomposite soap formulation for preventing chemical, biological, radiological, nuclear decontamination and nosocomial infections, characterized in that it comprises the process steps of: i. drying the plants at 25-50°C, ii. grinding and pulverizing the dried plants using a ball mill, iii. depositing the plant powders in a box, iv. adding 190-210 grams of sodium hydroxide (NaOH) to 0.9-1.1 liters of water and thus preparing a NaOH solution of 4.31 -5.55 mol / liter and leaving the solution to stand until the temperature reaches 93-100°C, v. adding and stirring 0.90-1.05 liters of olive oil to the NaOH solution of 5 mol / liter at 95°C, vi. upon a drop in the temperature of the mixture to the range of 50-60°C under the room conditions, adding the plant powders deposited in the box in the process step (iii) and stirring them again,vii. pouring the resulting mixture into molds and drying the same under the room conditions, in an area with no sunlight, viii. grating the dried material and adding thereto potable water up to 10-100 times its mass.

6. A method according to claim 5, characterized in that it comprises the process steps of: i. drying the plants at 30°C, ii. grinding and pulverizing the dried plants using a ball mill, iii. depositing the plant powders in a box, iv. adding 200 grams of sodium hydroxide (NaOH) to 1 liters of water and thus preparing a NaOH solution of 5 mol / liter and leaving the solution to stand until the temperature reaches 95°C, v. adding and stirring 1 liters of olive oil to the NaOH solution of 5 mol / liter at 95°C, vi. upon a drop in the temperature of the mixture to the range of 57°C under the room conditions, adding the plant powders deposited in the box in the process step (iii) and stirring them again, vii. pouring the resulting mixture into molds and drying the same under the room conditions, in an area with no sunlight, viii. grating the dried material and adding thereto potable water up to 50 times its mass.

7. A bioecocomposite soap formulation produced by a method according to any one of claims 5-6.