Apparatus and method for continuously synthesizing apatite powder using laser

Abstract

The present invention relates to an apparatus and a method for continuously synthesizing apatite powder, the apparatus comprising: a first microfluidic channel which communicates with a first inlet and through which a first precursor solution containing Ca2+ ions flows; a second microfluidic channel which communicates with a second inlet and through which a second precursor solution containing PO4 3- ions flows; a confluence unit in which the first microfluidic channel and the second microfluidic channel merge; a laser-emitting unit which communicates with the confluence unit and emits a laser; and a third microfluidic channel and an outlet which communicate with the laser-emitting unit.

Description

Device and method for continuous synthesis of apatite powder using a laser

[0001] The present invention is Ca 2+ Ions and PO4 3- A method for continuously synthesizing apatite powder by irradiating a laser onto a device configured to include microfluidic channels through which precursor solutions each containing ions flow separately.

[0002] Titanium-based alloys are reported to be superior to conventional biometals, which have been widely used in medical applications, due to their exceptional properties, such as low elasticity and excellent corrosion resistance. However, because titanium-based alloys are bioinert, they do not directly stimulate cellular activity, resulting in a significantly prolonged healing period for implants to achieve tissue-to-body integration. Furthermore, even bioinert materials can trigger an inflammatory response from the immune system when a foreign body is inserted into the body, negatively impacting stability and healing time.

[0003] To address these issues and shorten the recovery period after implantation, a common method is to specially treat the implant surface to impart bioactivity. For example, titanium, a material used for implants, can be treated with physical and chemical treatments to enhance its bioactivity, accelerating the healing process after implantation.

[0004] Apatite is one of the most widely used materials for surface treatment of titanium implants. A component of human hard tissue, apatite has a chemical composition similar to bone, resulting in high biocompatibility and excellent mechanical strength, making it ideal for bone formation.

[0005] Apatite is widely used in dental and orthopedic applications, and is therefore manufactured in a variety of particle forms, including particle shape, size, crystallinity, and porosity, to suit the specific application. To produce apatite particles with these specific properties, various methods, including solid-state reaction, precipitation, and hydrothermal synthesis, have been developed. However, these conventional methods have numerous problems.

[0006] Solid reaction and precipitation methods have the problem that the produced particles become large enough to reach several tens of micrometers in size because the heat treatment temperature is high, approximately 800°C to 1200°C, and complex subsequent processes such as mixing, calcination, and grinding are inevitably required after the reaction, making them economically inefficient.

[0007] Meanwhile, hydrothermal synthesis involves reacting amorphous, precipitated calcium phosphate in an autoclave at temperatures ranging from approximately 150 to 250°C for several hours. This method requires the mixing of multiple additives to increase reactivity during the hydrothermal synthesis process, and the long heating time required to increase purity not only consumes significant energy, but also requires a chamber capable of precisely controlling and maintaining temperature and pressure, making scalability problematic.

[0008] [Prior Art Literature]

[0009] [Patent Document]

[0010] Domestic Patent Publication No. 10-2579854 (September 13, 2023)

[0011] The present invention is to continuously synthesize apatite powder of uniform quality and to enable industrial use, and is connected to a first inlet, and Ca 2+ A first microfluidic channel through which an ion-containing first precursor solution flows; communicated with a second inlet, and PO4 3-The present invention provides an apatite powder continuous synthesis device, characterized by including a second microfluidic channel through which an ion-containing second precursor solution flows; a confluence portion where the first microfluidic channel and the second microfluidic channel join each other; a laser irradiation portion communicating with the confluence portion and irradiating a laser; and a third microfluidic channel and an outlet communicating with the laser irradiation portion.

[0012] However, the technical problems to be solved by the present invention are not limited to the problems mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the description below.

[0013] The present invention is connected to the first inlet, and Ca 2+ A first microfluidic channel through which an ion-containing first precursor solution flows; communicated with a second inlet, and PO4 3- A continuous apatite powder synthesis device is provided, characterized by comprising: a second microfluidic channel through which an ion-containing second precursor solution flows; a confluence portion where the first microfluidic channel and the second microfluidic channel join each other; a laser irradiation portion communicating with the confluence portion and irradiating a laser; and a third microfluidic channel and an outlet communicating with the laser irradiation portion.

[0014] The above apatite powder continuous synthesis device may be a polydimethylsiloxane (PDMS) material formed on a titanium-based substrate.

[0015] The first precursor solution or the second precursor solution may be based on a HEPES (Hydroxyethyl piperazine ethane sulfonic acid) buffer solution to adjust the pH to 4 or higher.

[0016] In the above first precursor solution, Ca 2+ The concentration of ions can be 10 mM to 30 mM.

[0017] In the above second precursor solution, PO4 3- The concentration of ions can be from 6 mM to 18 mM.

[0018] The above laser irradiation can be performed for 1 minute to 1 hour at a power range of 0.1 W to 20 W.

[0019] The above apatite powder has a flower shape and its size may be 0.8 ㎛ to 5 ㎛.

[0020] The above apatite powder may be unsubstituted or may be magnesium or iron substituted hydroxyapatite.

[0021] In one embodiment of the present invention, (a) Ca through the first inlet 2+ The first precursor solution containing ions is injected and moved into the first microfluidic channel, while PO4 is introduced through the second inlet. 3- The present invention provides a method for continuous synthesis of an apatite powder, comprising: (a) a step of injecting an ion-containing second precursor solution and moving it into a second microfluidic channel; (b) a step of reacting the first precursor solution moved into the first microfluidic channel and the second precursor solution moved into the second microfluidic channel at a confluence, and then irradiating a laser at a laser irradiation section to produce a solution containing an apatite powder; and (c) a step of separating the apatite powder-containing solution through a third microfluidic channel and an outlet, and then drying the same.

[0022] The continuous apatite powder synthesis device and method according to the present invention is Ca 2+ Ions and PO4 3- The invention is characterized by irradiating a laser onto a device configured to include microfluidic channels through which precursor solutions containing individual ions flow separately. Accordingly, the shape and size of the apatite powder can be controlled, and not only is the biocompatibility excellent, but productivity can also be increased by continuously synthesizing apatite powder of uniform quality, offering industrially applicable advantages.

[0023] In particular, in the apatite powder continuous synthesis device and method according to the present invention, Ca 2+ Ions and PO4 3- By separately injecting precursor solutions containing each ion and applying their optimal concentrations, continuous productivity can be maximized without clogging at the outlet through optimized flow conditions.

[0024] Figure 1 schematically illustrates a process for manufacturing an apatite powder continuous synthesis device according to one embodiment of the present invention.

[0025] Figures 2(a) and (b) schematically illustrate an apatite powder continuous synthesis device according to one embodiment of the present invention.

[0026] FIGS. 3(a) and (b) are photographs showing the shape and size of apatite powder confirmed through SEM analysis when a continuous apatite powder synthesis device according to one embodiment of the present invention was applied and laser irradiation of various powers was performed.

[0027] FIG. 4 is a photograph showing the shape of apatite powder confirmed through TEM analysis when a continuous apatite powder synthesis device according to one embodiment of the present invention is applied and laser irradiation of various powers is performed.

[0028] FIG. 5 is a graph showing the crystallinity of apatite powder confirmed through X-ray diffraction analysis when a continuous apatite powder synthesis device according to one embodiment of the present invention is applied and laser irradiation of various powers is performed.

[0029] The inventors of the present invention have conducted a prior study on synthesizing apatite powder by irradiating a laser onto the surface of a substrate immersed in a precursor solution. However, since the powder was manufactured in a static environment, the quality of the synthesized apatite powder was not uniform and the productivity was very low, which was a limitation.

[0030] To overcome this, the inventors of the present invention have developed Ca2+ Ions and PO4 3- By irradiating a laser onto a device (chip) configured to include microfluidic channels through which precursor solutions each containing ions flow separately to cause nucleation and growth of apatite powder, the present invention was completed by confirming that productivity can be increased by continuously synthesizing apatite powder with uniform quality and controlled shape and size.

[0031]

[0032] Hereinafter, the present invention will be described in detail.

[0033]

[0034] The "apatite powder" in this specification is widely used in dental and orthopedic applications, and is therefore manufactured in various forms, including particle shape, size, crystallinity, and porosity, to suit the field of application. Specifically, the apatite powder may be unsubstituted hydroxyapatite or hydroxyapatite substituted with various metals, such as magnesium or iron.

[0035]

[0036] Apatite powder continuous synthesis device

[0037]

[0038] The present invention is connected to the first inlet, and Ca 2+ A first microfluidic channel through which an ion-containing first precursor solution flows; communicated with a second inlet, and PO4 3- A continuous apatite powder synthesis device is provided, characterized by comprising: a second microfluidic channel through which an ion-containing second precursor solution flows; a confluence portion where the first microfluidic channel and the second microfluidic channel join each other; a laser irradiation portion communicating with the confluence portion and irradiating a laser; and a third microfluidic channel and an outlet communicating with the laser irradiation portion.

[0039]

[0040] First, the apatite powder continuous synthesis device may be formed of a polydimethylsiloxane (PDMS) material on a titanium substrate. The titanium substrate may be made of a titanium material or a titanium alloy material, and these are characterized in that they are metals that can be used for biomedical applications. In addition, the apatite powder continuous synthesis device is made of a polydimethylsiloxane (PDMS) material, and can be replaced with a material that allows fluid movement and is transparent to laser irradiation.

[0041]

[0042] Next, the apatite powder continuous synthesis device according to the present invention is a type of chip, which is connected to the first inlet and Ca 2+ A first microfluidic channel through which an ion-containing first precursor solution flows; and is connected to a second inlet, and PO4 3- Each of the second microfluidic channels comprises a second precursor solution containing ions flowing therethrough. In this way, Ca 2+ Ions and PO4 3- By allowing precursor solutions containing each ion to flow separately, nucleation and growth of apatite powder can be suppressed before laser irradiation.

[0043]

[0044] A first microfluidic channel starting from the first inlet and a second microfluidic channel starting from the second inlet can join at a certain angle to each other, and it is preferable that they join at an angle of 90° or less, and it is more preferable that they join at an angle of 60° or less, but it is not limited thereto. At this time, the width of the first microfluidic channel and the second microfluidic channel may each be 500 ㎛ to 2,000 ㎛, and the height may each be 100 ㎛ to 500 ㎛. The contact portion between the first inlet and the first microfluidic channel and the contact portion between the second inlet and the second microfluidic channel are both connected by a curve having a certain radius of curvature to ensure smooth fluid flow.

[0045]

[0046] The first precursor solution can be injected through the first inlet using a syringe pump and moved through the first microfluidic channel. At this time, the flow rate of the first precursor solution can be the same as or different from the flow rate of the second precursor solution. The first precursor solution is intended to serve as a calcium ion precursor, and is Ca 2+ ions (e.g., CaCl2). Meanwhile, the first precursor solution may additionally include a solution containing the metal ion when the apatite powder is substituted with various metals such as magnesium and iron. Meanwhile, the first precursor solution is preferably based on a HEPES (Hydroxyethyl piperazine ethane sulfonic acid) buffer solution to adjust the pH to 4 or higher, but is not limited thereto. At this time, the HEPES buffer solution is Ca 2+ It has the advantage of not reacting with ions, and the pH can be adjusted to 5 to 9, and preferably, the pH can be adjusted to 7.

[0047] Specifically, in the first precursor solution, Ca 2+The ion concentration may be 10 mM to 30 mM, preferably 15 mM to 25 mM, but is not limited thereto. With such optimized flow conditions, continuous productivity can be maximized due to the intermediate reaction rate and absence of clogging.

[0048]

[0049] Meanwhile, the second precursor solution can be injected through the second inlet using a syringe pump and moved through the second microfluidic channel. At this time, the flow rate of the second precursor solution can be the same as or different from the flow rate of the first precursor solution. The second precursor solution is intended to serve as a phosphate ion precursor, and is PO4. 3- It may contain ions (e.g., H3PO4). Meanwhile, the second precursor solution is also preferably based on a HEPES (Hydroxyethyl piperazine ethane sulfonic acid) buffer solution to adjust the pH to 4 or higher, but is not limited thereto. At this time, the HEPES buffer solution is PO4 3- It has the advantage of not reacting with ions, and the pH can be adjusted to 5 to 9, and preferably, the pH can be adjusted to 7.

[0050] Specifically, in the second precursor solution, PO4 3- The ion concentration may be 6 mM to 18 mM, preferably 9 mM to 15 mM, but is not limited thereto. With such optimized flow conditions, continuous productivity can be maximized due to the intermediate reaction rate and absence of clogging.

[0051]

[0052] Next, the apatite powder continuous synthesis device according to the present invention is configured to include a junction where the first microfluidic channel and the second microfluidic channel join each other, and a laser irradiation portion that is connected to the junction and irradiates a laser.

[0053]

[0054] At the above-mentioned junction, the first precursor solution and the second precursor solution can meet each other and cause a reaction. That is, the above-mentioned junction is a part where nucleation and growth of apatite powder can begin, and thereafter, nucleation and growth of apatite powder can fully occur upon laser irradiation.

[0055] At this time, the width of the confluence may be 500 ㎛ to 2,000 ㎛, and the height may be 100 ㎛ to 500 ㎛. In addition, the length of the confluence is 500 ㎛ to 20,000 ㎛ (preferably, 500 ㎛ to 10,000 ㎛), and by shortening the length of the confluence as in the above range, the laser irradiation is performed quickly after confluence. At this time, the length of the confluence refers to the distance from the starting point of the confluence to the center of the laser irradiation part described later. The starting point of the confluence where the first microfluidic channel and the second microfluidic channel confluence each other is connected by a curve having a constant radius of curvature to ensure smooth fluid flow.

[0056]

[0057] The above laser irradiation section is an area where the laser is irradiated by being closely connected to the junction section, and the laser irradiation can be performed using a Ytterbium Nanosecond Pulsed or femtosecond laser generator. In this case, the nanosecond laser has a pulse time of several nanoseconds, 10 -9 It refers to a laser with a short pulse width of 10 seconds, and a femtosecond laser is -15It refers to a laser having a very short pulse width of 1 second. Specifically, the laser irradiation can be performed in the range of 0.1 W to 20 W for 1 minute to 1 hour, preferably in the range of 0.5 W to 5 W for 1 minute to 1 hour, and more preferably in the range of 0.5 W to 2.5 W for 1 minute to 1 hour, but is not limited thereto. At this time, if the laser irradiation is not performed or the power is too weak, the yield of the apatite powder is greatly reduced, and there is a limitation that the size is too small to have a flower shape. If the power of the laser irradiation is excessively high, the size becomes too large, which causes a problem of clogging at the outlet. Meanwhile, the laser irradiation portion can have various shapes such as a circle, an oval, and a polygon, and the diameter can be 2000 ㎛ to 6000 ㎛. The contact point between the above-mentioned junction and the laser irradiation section is connected by a curve with a certain radius of curvature to ensure smooth fluid flow.

[0058]

[0059] If necessary, a cover glass can be additionally placed on the laser irradiation section.

[0060]

[0061] Next, the apatite powder continuous synthesis device according to the present invention is configured to include a third microfluidic channel and an outlet communicating with the laser irradiation unit.

[0062] Through the third microfluidic channel and the outlet, an apatite powder-containing solution (or an outlet solution) can be produced as a primary product. At this time, the width of the third microfluidic channel can be 500 μm to 2,000 μm, and the height can be 100 μm to 500 μm. The contact point between the laser irradiation unit and the third microfluidic channel and the contact point between the third microfluidic channel and the outlet are all connected by a curve having a constant radius of curvature to ensure smooth fluid flow.

[0063] The above apatite powder has a uniform quality, has a flower shape with overlapping petals, and may have a size of 0.8 ㎛ to 5 ㎛, preferably 1 ㎛ to 3 ㎛, but is not limited thereto.

[0064] If necessary, a composition may be added to precipitate and dry the apatite powder in the primary product.

[0065]

[0066] Continuous synthesis method of apatite powder

[0067]

[0068] The present invention comprises (a) Ca through a first inlet 2+ The first precursor solution containing ions is injected and moved into the first microfluidic channel, while PO4 is introduced through the second inlet. 3- The present invention provides a method for continuous synthesis of an apatite powder, comprising: (a) a step of injecting an ion-containing second precursor solution and moving it into a second microfluidic channel; (b) a step of reacting the first precursor solution moved into the first microfluidic channel and the second precursor solution moved into the second microfluidic channel at a confluence, and then irradiating a laser at a laser irradiation section to produce a solution containing an apatite powder; and (c) a step of separating the apatite powder-containing solution through a third microfluidic channel and an outlet, and then drying the same.

[0069]

[0070] The continuous apatite powder synthesis method according to the present invention is performed using the above-mentioned apatite powder continuous synthesis device, and since each component has been described above, a redundant description will be omitted.

[0071] The apatite powder finally synthesized through the above method is characterized by uniform quality and controlled shape and size. Since it can be molded into various shapes, it offers greater usability than when formed as a coating film.

[0072]

[0073] As reviewed above, the continuous apatite powder synthesis device and method according to the present invention is Ca 2+ Ions and PO4 3- The invention is characterized by irradiating a laser onto a device configured to include microfluidic channels through which precursor solutions containing individual ions flow separately. Accordingly, the shape and size of the apatite powder can be controlled, and not only is the biocompatibility excellent, but productivity can also be increased by continuously synthesizing apatite powder of uniform quality, offering industrially applicable advantages.

[0074] In particular, in the apatite powder continuous synthesis device and method according to the present invention, Ca 2+ Ions and PO4 3- By separately injecting precursor solutions containing each ion and applying their optimal concentrations, continuous productivity can be maximized without clogging at the outlet through optimized flow conditions.

[0075]

[0076] Hereinafter, preferred examples are presented to aid in understanding the present invention. However, the following examples are provided solely to facilitate a better understanding of the present invention, and the scope of the present invention is not limited by the following examples.

[0077]

[0078] [Example]

[0079] Manufacturing example

[0080] Referring to FIGS. 1 and 2(a) and (b), an apatite powder continuous synthesis device according to one embodiment of the present invention was manufactured through integration of components after a soft lithography process.

[0081] First, a silicon wafer (150 mm) was prepared, and then single chips (2.5 cm × 2.5 cm) were designed as follows. Specifically, the single chips were designed to include a first microfluidic channel (11) communicated with a first inlet (10) and through which a first precursor solution containing 100 mM HEPES and 220 mM CaCl2 flowed; a second microfluidic channel (21) communicated with a second inlet (20) and through which a second precursor solution containing 100 mM HEPES and 12 mM H3PO4 flowed; a confluence (30) where the first microfluidic channel (11) and the second microfluidic channel (21) join at a 60° angle to each other; a laser irradiation section (40) communicated with the confluence (30) and through which a laser is irradiated; and a third microfluidic channel (50) and an outlet (51) communicated with the laser irradiation section (40). Each of the first microfluidic channel (11), the second microfluidic channel (21), the confluence (30), and the third microfluidic channel (50) has a width of 1,000 μm and a height of 200 μm. At this time, the length of the confluence (30) is 5,750 μm, so that the laser irradiation can be performed quickly after confluence. In addition, the laser irradiation portion (40) is circular and has a diameter of 4,000 μm. At this time, in the apatite powder continuous synthesis device, all contact points between each component are connected in a curve having a constant radius of curvature to ensure smooth fluid flow. After curing PDMS on a Si wafer mold on which single chips are designed, a peel-off process was performed to perform a soft lithography process.

[0082] Next, the cut single chip was placed on a Ti6Al4V plate as a titanium substrate, and then punched and bonded. Next, component integration was performed by performing a tube connection operation to connect the first inlet (10), the second inlet (20), and the outlet (51). If necessary, a cover glass was placed on the laser irradiation section (40).

[0083]

[0084] Examples 1 to 5

[0085] In the manufacturing example, the apatite powder continuous synthesis device was manufactured, and the first precursor solution and the second precursor solution were injected at a flow rate of 1 mL / min using a syringe pump. In addition, laser irradiation was performed at various powers to derive the first product. At this time, the laser irradiation power was 0.5 W, 1.0 W, 1.5 W to 2.0 W, respectively, and the laser irradiation time was 25 minutes. Thereafter, in the derived first product, the apatite powder in the solution was precipitated, separated, and then dried.

[0086]

[0087] Comparative Example 1

[0088] The same method as in Examples 1 to 5 was used, except that laser irradiation was not performed.

[0089]

[0090] Apatite powder was synthesized continuously as in Example 1, Example 3, and Comparative Example 1, and then the yield of the apatite powder was measured (Table 1).

[0091]

[0092] Power of laser irradiation Yield of apatite powder Example 10.5 W 0.652 mg / ml Example 31.5 W 0.580 mg / ml Comparative example 10.0 W 0.426 mg / ml

[0093]

[0094] As shown in Table 1, when laser irradiation was performed as in Examples 1 and 3, the yield of apatite powder was higher than 0.5 mg / ml, but when laser irradiation was not performed as in Comparative Example 1, the yield of apatite powder was confirmed to be greatly reduced.

[0095]

[0096] In addition, SEM and TEM analyses were performed on the apatite powders continuously synthesized according to Examples 1 to 5 and Comparative Example 1 (Table 2, Figs. 3(a) and (b) and Fig. 4).

[0097]

[0098] Power of laser irradiation Size of apatite powder Example 10.5 W 1.31±0.27 ㎛ Example 21.0 W 1.42±0.42 ㎛ Example 31.5 W 2.08±0.51 ㎛ Example 42.0 W 2.40±0.42 ㎛ Comparative example 10.0 W 0.63±0.10 ㎛

[0099]

[0100] As shown in Table 2, Figs. 3(a) and (b) and Fig. 4, when laser irradiation was performed as in Examples 1 to 5, it was confirmed that flower-shaped apatite powder was formed. The size was confirmed to be 0.8 µm to 5 µm (particularly, 1 µm to 3 µm). On the other hand, when laser irradiation was not performed as in Comparative Example 1, the size of the apatite powder was confirmed to be too small and simply a powder shape.

[0101]

[0102] In addition, X-ray diffraction analysis was performed on the apatite powders continuously synthesized according to Example 1, Example 3, and Comparative Example 1 (Fig. 5).

[0103] As shown in Fig. 5, it was confirmed that apatite powder was synthesized in both cases where laser irradiation was performed, as in Examples 1 and 3, and in cases where laser irradiation was not performed, as in Comparative Example 1. In particular, it was confirmed that as the power of laser irradiation increased, as in Examples 1 and 3, the degree of crystallinity tended to decrease. In the case of apatite with low crystallinity, liquid penetration is fast and it is easily dissolved in the body.

[0104]

[0105] The foregoing description of the present invention is for illustrative purposes only. Those skilled in the art will readily appreciate that modifications to other specific embodiments can be made without altering the technical spirit or essential characteristics of the present invention. Therefore, the embodiments described above should be understood as illustrative in all respects and not restrictive.

Claims

1. Connected to the first entrance, Ca 2+ A first microfluidic channel through which an ion-containing first precursor solution flows; Connected to the second entrance, PO4 3- A second microfluidic channel through which a second precursor solution containing ions flows; A confluence portion where the first microfluidic channel and the second microfluidic channel join each other; A laser irradiation unit that is connected to the above-mentioned joining unit and irradiates a laser; and An apatite powder continuous synthesis device characterized by including a third microfluidic channel and an outlet communicating with the laser irradiation unit.

2. In paragraph 1, The above apatite powder continuous synthesis device is characterized in that the apatite powder continuous synthesis device is made of a polydimethylsiloxane (PDMS) material formed on a titanium-based substrate.

3. In paragraph 1, An apatite powder continuous synthesis device, characterized in that the first precursor solution or the second precursor solution is based on a HEPES (Hydroxyethyl piperazine ethane sulfonic acid) buffer solution for adjusting the pH to 4 or higher.

4. In paragraph 1, In the above first precursor solution, Ca 2+ A continuous apatite powder synthesis device, characterized in that the concentration of ions is 10 mM to 30 mM.

5. In paragraph 1, In the above second precursor solution, PO4 3- A continuous apatite powder synthesis device, characterized in that the concentration of ions is 6 mM to 18 mM.

6. In paragraph 1, An apatite powder continuous synthesis device, characterized in that the above laser irradiation is performed for 1 minute to 1 hour in the range of 0.1 W to 20 W.

7. In paragraph 1, An apatite powder continuous synthesis device, characterized in that the apatite powder has a flower shape and a size of 0.8 ㎛ to 5 ㎛.

8. In paragraph 1, An apatite powder continuous synthesis device, characterized in that the above apatite powder is unsubstituted or magnesium or iron substituted hydroxyapatite. 9.(a) Ca through the first entrance 2+ The first precursor solution containing ions is injected and moved into the first microfluidic channel, while PO4 is introduced through the second inlet. 3- A step of injecting a second precursor solution containing ions and moving it into a second microfluidic channel; (b) a step of reacting the first precursor solution moved to the first microfluidic channel and the second precursor solution moved to the second microfluidic channel at a confluence, and then irradiating a laser at a laser irradiation section to produce a solution containing apatite powder; and (c) A continuous apatite powder synthesis method characterized by comprising a step of separating the apatite powder-containing solution through a third microfluidic channel and an outlet, and then drying it.

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