A sub-assembly of a medicament delivery device

Abstract

A sub-assembly of a medicament delivery device for preventing accidentally triggering the medicament delivery device operation, the sub-assembly comprising a housing extending along a longitudinal axis between a proximal end and a distal end; a delivery member guard at least partially accommodated by and telescopically moveable relative to the housing; and a cap removably attachable to the proximal end of the housing, the cap having a protrusion with a proximally directed surface; the protrusion and an edge of the opening facing the protrusion in a circumferential direction provide a cam interface such that when the cap is rotated around the longitudinal axis, the protrusion is guided to move radially outwards out of the opening and so as to move the proximally directed surface away from the distally directed surface to enable the delivery member guard to be moved in the distal direction.

Description

[0001] TITLE

[0002] A sub-assembly of a medicament delivery device

[0003] TECHNICAL FIELD

[0004] The present disclosure generally relates to a sub-assembly of a medicament delivery device, and particularly to a sub-assembly comprises a cam interface between a cap and a housing.

[0005] BACKGROUND

[0006] Medicament delivery devices such as auto-injectors, inhalers and on-body devices are generally known for the self-administration of a medicament by patients without formal medical training. Therefore, those medicament delivery devices usually comprise multiple automatic functions and are usually delivered to end-users with prefilled medicament containers. Although there are many well-designed medicament delivery devices usually with multiple automatic functions in the market, there are still long-term remaining issues to be solved.

[0007] For example, some medicament delivery devices are designed to be triggered by a distal movement of a delivery member guard as the delivery member guard is configured to be in contact and pressed on a medicament delivery site at the as a first step of using the medicament delivery site. However, there is a risk that when the medicament delivery device falls on a hard surface, in particular, when a distal end of the medicament delivery device be in contact with the hard surface, the inertia might cause the delivery member guard to move in the distal direction and therefore, accidentally triggers the medicament delivery device operation.

[0008] It has been appreciated that improved solutions for providing a reliable prevention mechanism for the above-mentioned issue that can be used with a more powerful power source. SUMMARY

[0009] The invention is defined by the appended claims, to which reference should now be made.

[0010] In the present disclosure, when the term “distal direction” is used, this refers to the direction pointing away from the dose delivery site during use of the medicament delivery device. When the term “distal part / end” is used, this refers to the part / end of the delivery device, or the parts / ends of the members thereof, which under use of the medicament delivery device is / are located furthest away from the dose delivery site. Correspondingly, when the term “proximal direction” is used, this refers to the direction pointing towards the dose delivery site during use of the medicament delivery device. When the term “proximal part / end” is used, this refers to the part / end of the delivery device, or the parts / ends of the members thereof, which under use of the medicament delivery device is / are located closest to the dose delivery site.

[0011] Further, the term “longitudinal”, “longitudinally”, “axially” or “axial” refer to a direction extending from the proximal end to the distal end, typically along the device or components thereof in the direction of the longest extension of the device and / or component.

[0012] Similarly, the terms “transverse”, “transversal” and “transversally” refer to a direction generally perpendicular to the longitudinal direction.

[0013] Further, the terms “circumference”, “circumferential”, or “circumferentially” refer to a circumference or a circumferential direction relative to an axis, typically a central axis extending in the direction of the longest extension of the device and / or component. Similarly, “radial” or “radially” refer to a direction extending radially relative to the axis, and “rotation”, “rotational” and “rotationally” refer to rotation relative to the axis.

[0014] There is hence provided a sub-assembly of a medicament delivery device for preventing accidentally triggering the medicament delivery device operation. The sub-assembly comprises a sub-assembly of a medicament delivery device, the sub-assembly comprising: a housing extending along a longitudinal axis between a proximal end and a distal end; a delivery member guard at least partially accommodated by and telescopically moveable relative to the housing; and a cap removably attachable to the proximal end of the housing, the cap having a protrusion with a proximally directed surface. The housing has a wall located radially between the delivery member guard and the cap when the cap is attached to the proximal end of the housing, and an opening in the wall. When the cap is attached to the proximal end of the housing, the protrusion extends through the opening such that the proximally directed surface faces a distally directed surface of the delivery member guard to restrict movement of the delivery member guard in the distal direction relative to the cap and to the housing. The protrusion and an edge of the opening facing the protrusion in a circumferential direction provide a cam interface such that when the cap is rotated around the longitudinal axis, the protrusion is guided to move radially outwards out of the opening and so as to move the proximally directed surface away from the distally directed surface to enable the delivery member guard to be moved in the distal direction.

[0015] Preferably, according to another embodiment, the edge of the opening is a cam surface and the protrusion is a cam follower.

[0016] Preferably, according to another embodiment, the protrusion comprises a curved surface located adjacent to the cam surface when the cap is attached to the proximal end of the housing.

[0017] Preferably, according to another embodiment, the protrusion comprises a generally oval shaped section when observes in the radial direction relative to the longitudinal axis positioned next to the edge of the opening of the housing.

[0018] Preferably, according to another embodiment, the edge of the opening comprises two cam surfaces inclined in the radial direction to the longitudinal axis and extending closer one another in the proximal direction such that the opening comprises a distal width and a proximal width smaller than the distal width.

[0019] Preferably, according to another embodiment, the protrusion comprises a width being smaller than the proximal width of the opening such that when the protrusion is moved in the proximal direction relative to the opening, the protrusion is guided to move away from the distally directed surface to enable the delivery member guard by the cam surfaces.

[0020] Preferably, according to another embodiment, the opening is generally triangular when observes in the radial direction relative to the longitudinal axis.

[0021] Preferably, according to another embodiment, the delivery member guard comprises a rib extending in the radial direction relative to the longitudinal axis.

[0022] Preferably, according to another embodiment, the rib comprises the distally directed surface.

[0023] Preferably, according to another embodiment, the rib of the delivery member guard comprises a proximally directed cam surface positioned opposite to the distally directed surface in the direction of the longitudinal axis.

[0024] Preferably, according to another embodiment, the cap comprises a distally directed surface be in contact with a proximally directed surface of the delivery member guard when the cap is attached to the proximal end of the housing.

[0025] Preferably, according to another embodiment, the delivery member guard comprises a first length measured along the longitudinal axis from a proximal end of the delivery member guard to the proximal end of the housing when a tubular proximal section of the delivery member guard is in a fully extended position. Preferably, according to another embodiment, a second length is defined between the distally directed surface of the cap and the proximal end of the housing along the longitudinal axis; and wherein the second length is shorter than the first length.

[0026] Preferably, according to another embodiment, the cap is in contact with the housing via a cam interface such that when the cap is rotated around the longitudinal axis, the cap is guided to move in the direction of the longitudinal axis by the cam interface.

[0027] Preferably, according to another embodiment, a cut-out is arranged in a wall of the cap.

[0028] Preferably, according to another embodiment, the cut-out is adjacent to the protrusion of the cap.

[0029] Preferably, according to another embodiment, the housing comprises a slot extending from the opening to the proximal end of the housing.

[0030] Preferably, according to another embodiment, the medicament delivery device comprises the medicament container having a delivery member extending from a proximal end of the medicament container; wherein the medicament delivery device comprises the sub-assembly.

[0031] Preferably, according to another embodiment, the medicament container is a syringe, a cartridge or a collapsible bag.

[0032] Preferably, according to another embodiment, the delivery member is an injection needle.

[0033] Preferably, according to another embodiment, the medicament delivery device comprises the medicament container having a movable stopper sealing a distal opening of the medicament container. Preferably, according to another embodiment, the power source is a spring being pre-tensioned between a first end of the spring to the second end of the spring.

[0034] Preferably, according to another embodiment, the first end of the spring is in contact with the plunger rod and second end of the spring is in contact with the housing.

[0035] Preferably, according to another embodiment, the medicament delivery device is an injection device, an inhalation device, or a medical sprayer.

[0036] Preferably, according to another embodiment, the injection device is a handhold, pen type injector.

[0037] Preferably, according to another embodiment, the handhold, pen type injector is an autoinjector.

[0038] Generally, all terms used in the claims are to be interpreted according to their ordinary meaning in the technical field, unless explicitly defined otherwise herein. All references to "a / an / the element, apparatus, component, means, etc.” are to be interpreted openly as referring to at least one instance of the element, apparatus, component, means, etc., unless explicitly stated otherwise.

[0039] BRIEF DESCRIPTION OF THE DRAWINGS

[0040] Embodiments of the inventive concept will now be described, by way of example only, with reference to the accompanying drawings, in which:

[0041] Fig. 1 schematically shows a perspective view of a sub-assembly of the disclosure;

[0042] Fig. 2 schematically shows a perspective view of the sub-assembly of Fig. 1 without a cap;

[0043] Fig. 3 schematically shows a perspective view of a cap of the sub-assembly of Fig. 1 ; Fig. 4 schematically shows a perspective view of a delivery member guard of the sub-assembly of Fig. 1 ;

[0044] Figs 5-6 schematically shows a perspective view of a housing of the subassembly of Fig. 1 ;

[0045] Fig. 7 schematically show a cross-section view of the sub-assembly of Fig. 1 ;

[0046] Fig. 8 schematically shows a perspective view of the sub-assembly of Fig. 1 when the delivery member guard moves in a distal direction when the cap is attached to the housing;

[0047] Figs 9-10 schematically shows perspective views of the sub-assembly of Fig. 1 when the cap is rotated relative to the housing, and axially moved without rotation relative to the housing; and

[0048] Figs 11 -12 schematically shows perspective views of the sub-assembly of Fig. 1 when the cap and the delivery member guard are both moved in the proximal direction relative to the housing.

[0049] DETAILED DESCRIPTION

[0050] Figs 1 -14 illustrate a sub-assembly of medicament delivery device for preventing accidentally triggering the medicament delivery device operation. The medicament delivery device is configured to accommodate a medicament container with prefilled medicament and expel the contained medicament via a medicament delivery member extending from a proximal end of the medicament container to a medicament delivery site upon the medicament delivery device being activated. The medicament delivery member is attached to the medicament container when the medicament delivery device is ready to be activated. The medicament container can be a glass / plastic syringe with an integral medicament delivery member; or the medicament container can be a glass / plastic cartridge without medicament delivery member. In one example where the medicament container is a cartridge, a user of the medicament delivery device needs to attach a medicament delivery member to the cartridge before the medicament delivery device is ready to be activated. For example, the user can manually attach a medicament delivery member or trigger an attaching mechanism of the medicament delivery device such that the medicament container is connected to a medicament delivery member. In one example, the medicament delivery member is an injection needle. In this example, the medicament delivery device is an injection device. The medicament delivery device is configured to be activated by a movement of a delivery member guard 3 away from the medicament delivery site. In this example, the delivery member guard 3 is configured to enclose the medicament delivery member during operation of the medicament delivery device, the delivery member guard 3 is also configured to be in contact with the medicament delivery site; thus, in this example, the user of the medicament delivery device can be guided by the operation steps of the device to aim the medicament delivery member toward the medicament delivery site when the user plans to activate the medicament delivery device (by pushing the delivery member guard on the medicament delivery site such that the delivery member guard can be moved away from the medicament delivery site).

[0051] The sub-assembly comprises a housing 1 extending along a longitudinal axis L between a proximal end and a distal end, as shown in Fig. 1 ; a delivery member guard 3 at least partially accommodated by and telescopically moveable relative to the housing 1 , as shown in Fig. 2; and a cap 2 removably attachable to the proximal end of the housing 1 , the cap 2 having a protrusion 21 with a proximally directed surface 21a, as shown in Figs 1 , 3 and 7-8.

[0052] The housing 1 is configured to accommodate the medicament container of the medicament delivery device. In one example, the housing 1 comprises a window 12 configured to be lined up with the medicament container such that the user can observe the medicament container via the window. Alternatively, or additionally, the housing can be made of transparent material. The delivery member guard 3 comprises a tubular proximal section 30 configured to enclose the medicament delivery member of the medicament delivery device when the delivery member guard 3 is protruding from the proximal end of the housing 1. In a preferred example, as shown in Fig. 4, the tubular proximal section 30 of the delivery member guard 3 comprises a flange 34 such that the flange can facilitate the user to flat the skin surface when the user plans to start a medicament delivery operation. The flange 34 comprises a contact surface 35 configured to be in contact with the medicament delivery site during use.

[0053] The cap 2 is configured to cover the medicament delivery member before use and is configured to be removed by an end user of the medicament delivery device. The cap 2 is attached to the proximal end of the housing 1 , as shown in Fig. 1 . The cap 2 comprises a wall 20, as shown in Fig. 3. In a preferred example, the protrusion 21 extends radially towards the longitudinal axis L from the wall 20 of the cap 2. In a preferred example, the cap 2 is in contact with the housing 1 via a cam interface such that when the cap 2 is rotated around the longitudinal axis L, the cap is guided to move in the direction of the longitudinal axis L by the cam interface. For example, the cap 2 comprises a curved edge 23 configured to be matched with a counter curved edge 13 of the housing. As a result, the cam surface formed between the cap 2 and the housing 1 when the cap 2 is attached to the proximal end of the housing 1 . In this example, when the end user rotates the cap 2 around the longitudinal axis L relative to the housing 1 , the cam surface transfers the rotation of the cap 2 to axial movement of the cap 2 relative to the housing 1 , so that the cap 2 is detached from the housing 1 . Alternatively, or additionally, the user can pull the cap 2 axially without rotation relative to the housing 1 to detach the cap 2 from the housing 1 .

[0054] The housing 1 has a wall 10 located radially between the delivery member guard 3 and the cap 2 when the cap is attached to the proximal end of the housing 1 , and an opening 11 in the wall 10. When the cap 2 is attached to the proximal end of the housing 1 , the protrusion 21 extends through the opening 11 such that the proximally directed surface 21a faces a distally directed surface 31 of the delivery member guard 3 to restrict movement of the delivery member guard 3 in the distal direction D relative to the cap 2 and to the housing 1 , as shown in Figs 7-8. The protrusion 21 and an edge of the opening 11 facing the protrusion 21 in a circumferential direction R provide a cam interface such that when the cap 2 is rotated around the longitudinal axis L, the protrusion 21 is guided to move radially outwards out of the opening 11 , as shown in Fig. 9, and so as to move the proximally directed surface 21a away from the distally directed surface 31 to enable the delivery member guard 3 to be moved in the distal direction.

[0055] The sub-assembly of the disclosure is more suitable for the medicament delivery device that is configured to use the distal movement of the delivery member guard to trigger. For example, the distal movement of the delivery member guard can trigger the medicament delivery operation or the distal movement of the delivery member guard together with a movement of a button of the medicament delivery device. As a result, when the cap is attached to the housing, the delivery member guard is prevented from moving in the distal direction to trigger the medicament delivery operation. It should be noted that the description of this disclosure will not explain further how to trigger an operation of the medicament delivery device by the distal movement of the delivery member guard because there are many different ways of trigger such function (see e.g. the disclosure of WO2011005177A1 and / or WO2011123024), and also such trigger mechanism of the medicament delivery operation is not a part of the invention.

[0056] In one example, the edge of the opening 11 is a cam surface 11a, as shown in Fig. 5, and the protrusion 21 is a cam follower. Preferably, the protrusion 21 comprises a curved surface located adjacent to the cam surface 11a when the cap is attached to the proximal end of the housing 1 . Preferably, the protrusion comprises a generally oval shaped section when observes in the radial direction relative to the longitudinal axis L positioned next to the edge of the opening 11 of the housing 1 , as shown in Fig. 9. In another example, the edge of the opening 11 comprises two cam surfaces 11a, 11b inclined in the radial direction to the longitudinal axis L and extending closer one another in the proximal direction P, as shown in Fig. 3, such that the opening 11 comprises a distal width and a proximal width smaller than the distal width. In this example, the protrusion 21 comprises a width being smaller than the proximal width of the opening 11 such that when the protrusion 21 is moved in the proximal direction P relative to the opening 11 , the protrusion 21 is guided to move away from the longitudinal axis L by the cam surfaces 11a, 11 b. Therefore, when the user pulls off the cap 2 without rotating the cap 2 relative to the housing 1 , the protrusion 21 can also be moved away from the distally directed surface 31 to enable the delivery member guard 3 to be moved in the distal direction. In a preferred example, the opening 11 is generally triangular when observes in the radial direction relative to the longitudinal axis L, as shown in Fig. 10.

[0057] Furthermore, in one example, the delivery member guard 3 comprises a rib

[0058] 32 extending in the radial direction relative to the longitudinal axis L, as shown in Fig. 4. The rib 32 comprises the distally directed surface 31 . The rib of the delivery member guard 3 comprises a proximally directed cam surface

[0059] 33 positioned opposite to the distally directed surface 31 in the direction of the longitudinal axis L, as shown in Fig. 4. In this example, the delivery member guard 3 is configured to move a predetermined distance in the proximal direction when the cap 2 is removed from the housing 1 , the rib 32 of the delivery member guard 3 is moved to be covered by the wall 10 of the housing 1 by the proximal movement of the delivery member guard 3, as shown in Figs 11-12. As a result, the rib 32 will not interfere with the cap 2 during cap removal.

[0060] In one example, the cap 2 comprises a distally directed surface 25 be in contact with a proximally directed surface 35 of the delivery member guard 3 when the cap 2 is attached to the proximal end of the housing 1 , as shown in Fig. 11. In a preferred example, the delivery member guard 3 comprises a first length measured along the longitudinal axis L from a proximal end of the delivery member guard 3 to the proximal end of the housing 1 when the tubular proximal section 30 of the delivery member guard 3 is in a fully extended position. A second length is defined between the distally directed surface of the cap 2 and the proximal end of the housing 1 along the longitudinal axis L. The second length is shorter than the first length, as shown in Figs 11-12. In other words, the delivery member guard 3 is configured to be moved in the proximal direction for the predetermined distance when the cap 2 is removed from the housing. For example, a spring is located and pretensioned between the housing and the delivery member guard and the spring is configured to push the delivery member guard in the proximal direction relative to the housing. In one example, the cap might comprise a delivery member remover configured to engage with a delivery member shield. In one example where the delivery member is a needle, the delivery member shield can be a rubber sheath, or a rubber sheath enclosed by a plastic cap. In this example, the friction between the rubber sheath can the delivery member and / or the medicament container is higher than the spring force when the spring is compressed with the predetermined distance. Thus, before the cap is detached from the housing, the delivery member guard is pushed against the spring force by the cap. During the cap removal, the delivery member guard is moved in the proximal direction by the spring until the delivery member guard reaches to the fully extended position. Alternatively, or additionally, the cap is attached to the housing via a snap-fit feature, e.g., a bump positioned in a recess / cut-out of the housing, that can be released by applying force with a predetermined magnitude. In this example, the predetermined magnitude is greater than the spring force when the spring is compressed with the predetermined distance.

[0061] In another example, a cut-out 22 is arranged in the wall 20 of the cap 2. The cut-out 22 is adjacent to the protrusion 21 of the cap 2. Thus, the flexibility of the wall 20 of the cap 2 can be increased and therefore the protrusion can be moved away from the distally directed surface of the delivery member guard 3 easily when the cap 2 is removed from the housing 1 . In another example, the housing 1 comprises a slot 14 extending from the opening 11 to the proximal end of the housing, as shown in Fig. 6.

[0062] Preferably, the rib 32 of the delivery member guard 3 is configured to move within the slot 14.

[0063] Furthermore, the housing 1 of the medicament delivery device, as mentioned in any example, may be provided with (i.e. , molded in, molded with) a compound featuring persistently antimicrobial, antifungal, and / or antiviral properties. Alternatively, a compound featuring persistently antimicrobial, antifungal, and / or antiviral properties may be applied to the molded (i.e., finished) components through secondary processes (e.g., chemical vapor deposition), spraying, or dipping processes. The housing can be one single component or formed by multiple components being assembled dependent on the manufacture process. Similarly, the delivery member guard and / or the plunger rod / and / or the actuator can be one single component respectively or formed by multiple components being assembled respectively dependent on the manufacture process.

[0064] The medicament delivery devices described herein can be used for the treatment and / or prophylaxis of one or more of many different types of disorders. Exemplary disorders include, but are not limited to: rheumatoid arthritis, inflammatory bowel diseases (e.g. Crohn’s disease and ulcerative colitis), hypercholesterolaemia, diabetes (e.g. type 2 diabetes), psoriasis, migraines, multiple sclerosis, anaemia, lupus, atopic dermatitis, asthma, nasal polyps, acute hypoglycaemia, obesity, anaphylaxis and allergies. Exemplary types of medicaments that could be included in the medicament delivery devices described herein include, but are not limited to, small molecules, hormones, cytokines, blood products, antibodies, antibody-drug conjugates, bispecific antibodies, proteins, fusion proteins, peptibodies, polypeptides, pegylated proteins, protein fragments, protein analogues, protein variants, protein precursors, chimeric antigen receptor T cell therapies, cell or gene therapies, oncolytic viruses, or immunotherapies and / or protein derivatives. Exemplary medicaments that could be included in the medicament delivery devices described herein include, but are not limited to (with non-limiting examples of relevant disorders in brackets): etanercept (rheumatoid arthritis, inflammatory bowel diseases (e.g. Crohn’s disease and ulcerative colitis)), evolocumab (hypercholesterolaemia), exenatide (type 2 diabetes), secukinumab (psoriasis), erenumab (migraines), alirocumab (rheumatoid arthritis), methotrexate (amethopterin) (rheumatoid arthritis), tocilizumab (rheumatoid arthritis), interferon beta-1 a (multiple sclerosis), sumatriptan (migraines), adalimumab (rheumatoid arthritis), darbepoetin alfa (anaemia), belimumab (lupus), peginterferon beta-1 a' (multiple sclerosis), sarilumab (rheumatoid arthritis), semaglutide (type 2 diabetes, obesity), dupilumab (atopic dermatitis, asthma, nasal polyps, allergies), glucagon (acute hypoglycaemia), epinephrine (anaphylaxis), insulin (diabetes), atropine and vedolizumab (inflammatory bowel diseases (e.g. Crohn’s disease and ulcerative colitis)) , ipilimumab, nivolumab, pembrolizumab, atezolizumab, durvalumab, avelumab, cemiplimab, rituximab, trastuzumab, ado-trastuzumab emtansine, fam-trastuzumab deruxtecan-nxki, pertuzumab, transtuzumab-pertuzumab, alemtuzumab, belantamab mafodotin-blmf, bevacizumab, blinatumomab, brentuximab vedotin, cetuximab, daratumumab, elotuzumab, gemtuzumab ozogamicin, 90-Yttrium- ibritumomab tiuxetan, isatuximab, mogamulizumab, moxetumomab pasudotox, obinutuzumab, ofatumumab, olaratumab, panitumumab, polatuzumab vedotin, ramucirumab, sacituzumab govitecan, tafasitamab, or margetuximab. Pharmaceutical formulations including, but not limited to, any drug described herein are also contemplated for use in the medicament delivery devices described herein, for example, pharmaceutical formulations comprising a drug as listed herein (or a pharmaceutically acceptable salt of the drug) and a pharmaceutically acceptable carrier. Pharmaceutical formulations comprising a drug as listed herein (or a pharmaceutically acceptable salt of the drug) may include one or more other active ingredients, or may be the only active ingredient present.

[0065] Exemplary medicaments that could be included in the medicament delivery devices described herein include, but are not limited to, an immuno-oncology or bio-oncology medications such as immune checkpoints, cytokines, chemokines, clusters of differentiation, interleukins, integrins, growth factors, enzymes, signaling proteins, pro-apoptotic proteins, anti-apoptotic proteins, T-cell receptors, B-cell receptors, or costimulatory proteins.

[0066] Exemplary medicaments that could be included in the medicament delivery devices described herein include, but are not limited to, those exhibiting a proposed mechanism of action, such as HER-2 receptor modulators, interleukin modulators, interferon modulators, CD38 modulators, CD22 modulators, CCR4 modulators, VEGF modulators, EGFR modulators, CD79b modulators, Trop-2 modulators, CD52 modulators, BCMA modulators, PDGFRA modulators, SLAMF7 modulators, PD-1 / PD-L1 inhibitors / modulators, B-lymphocyte antigen CD19 inhibitors, B-lymphocyte antigen CD20 modulators, CD3 modulators, CTLA-4 inhibitors, TIM-3 modulators, VISTA modulators, INDO inhibitors, LAG3 (CD223) antagonists, CD276 antigen modulators, CD47 antagonists, CD30 modulators, CD73 modulators, CD66 modulators, CDw137 agonists, CD158 modulators, CD27 modulators, CD58 modulators, CD80 modulators, CD33 modulators, APRIL receptor modulators, HLA antigen modulators, EGFR modulators, B- lymphocyte cell adhesion molecule modulators, CDw123 modulators, Erbb2 tyrosine kinase receptor modulators, mesothelin modulators, HAVCR2 antagonists, NY-ESO-1 0X40 receptor agonist modulators, adenosine A2 receptors, ICOS modulators, CD40 modulators, TIL therapies, or TCR therapies.

[0067] Exemplary medicaments that could be included in the medicament delivery devices described herein include, but are not limited to, a multi-medication treatment regimen such as AC, Dose-Dense AC, TCH, GT, EC, TAC, TC, TCHP, CMF, FOLFOX, mF0LF0X6, mF0LF0X7, FOLFCIS, CapeOx, FLOT, DCF, FOLFIRI, FOLFIRINOX, FOLFOXIRI, IROX, CHOP, R-CHOP, RCHOP-21 , Mini-CHOP, Maxi-CHOP, VR-CAP, Dose-Dense CHOP, EPOCH, Dose-Adjusted EPOCH, R-EPOCH, CODOX-M, IVAC, HyperCVAD, R-HyperCVAD, SC-EPOCH-RR, DHAP, ESHAP, GDP, ICE, MINE, CEPP, CDOP, GemOx, CEOP, CEPP, CHOEP, CHP, GCVP, DHAX, CALGB 8811 , HIDAC, MOpAD, 7 + 3, 5 +2, 7 + 4, MEC, CVP, RBAC500, DHA-Cis, DHA- Ca, DHA-Ox, RCVP, RCEPP, RCEOP, CMV, DDMVAC, GemFLP, ITP, VIDE, VDC, VAI, VDC-IE, MAP, PCV, FCR, FR, PCR, HDMP, OFAR, EMA / CO, EMA / EP, EP / EMA, TP / TE, BEP, TIP, VIP, TPEx, ABVD, BEACOPP, AVD, Mini-BEAM, IGEV, C-MOPP, GCD, GEMOX, CAV, DTPACE, VTD-PACE, DCEP, ATG, VAC, VelP, OFF, GTX, CAV, AD, MAID, AIM, VAC-IE, ADOC, or PE.

[0068] Exemplary medicaments that could be included in the medicament delivery devices described herein include, but are not limited to, those used for chemotherapy, such as an alkylating agent, plant alkaloid, antitumor antibiotic, antimetabolite, or topoisomerase inhibitor, enzyme, retinoid, or corticosteroid. Exemplary chemotherapy medicaments include, by way of example but not limitation, 5-fluorouracil, cisplatin, carboplatin, oxaliplatin, doxorubicin, daunorubicin, idarubicin, epirubicin, paclitaxel, docetaxel, cyclophosphamide, ifosfamide, azacitidine, decitabine, bendamustine, bleomycin, bortezomib, busulfan, cabazitaxel, carmustine, cladribine, cytarabine, dacarbazine, etoposide, fludarabine, gemcitabine, irinotecan, leucovorin, melphalan, methotrexate, pemetrexed, mitomycin, mitoxantrone, temsirolimus, topotecan, valrubicin, vincristine, vinblastine, or vinorelbine.

[0069] The inventive concept has mainly been described above with reference to a few examples. However, as is readily appreciated by a person skilled in the art, other embodiments than the ones disclosed above are equally possible within the scope of the inventive concept, as defined by the appended claims.

Claims

CLAIMS1 . A sub-assembly of a medicament delivery device for preventing accidentally triggering the medicament delivery device operation, the sub-assembly comprising: a housing (1 ) extending along a longitudinal axis (L) between a proximal end and a distal end; a delivery member guard (3) at least partially accommodated by and telescopically moveable relative to the housing (1 ); and a cap (2) removably attachable to the proximal end of the housing (1 ), the cap (2) having a protrusion (21 ) with a proximally directed surface (21 a); wherein the housing (1 ) has a wall (10) located radially between the delivery member guard (3) and the cap (2) when the cap is attached to the proximal end of the housing (1 ), and an opening (11 ) in the wall (10), wherein when the cap (2) is attached to the proximal end of the housing (1 ), the protrusion (21 ) extends through the opening (11 ) such that the proximally directed surface (21 a) faces a distally directed surface (31 ) of the delivery member guard (3) to restrict movement of the delivery member guard (3) in the distal direction relative to the cap (2) and to the housing (1 ), and wherein the protrusion (21 ) and an edge of the opening (11 ) facing the protrusion (21 ) in a circumferential direction provide a cam interface such that when the cap (2) is rotated around the longitudinal axis (L), the protrusion (21 ) is guided to move radially outwards out of the opening (11 ) and so as to move the proximally directed surface (21 a) away from the distally directed surface (31 ) to enable the delivery member guard (3) to be moved in the distal direction.

2. The sub-assembly according to claim 1 , wherein the edge of the opening (11 ) is a cam surface (11 a) and the protrusion is a cam follower.

3. The sub-assembly according to claim 2, wherein the protrusion comprises a curved surface located adjacent to the cam surface (11a) when the cap is attached to the proximal end of the housing.

4. The sub-assembly according to claim 3, wherein the protrusion comprises a generally oval shaped section when observes in the radial direction relative to the longitudinal axis (L) positioned next to the edge of the opening (11 ) of the housing (1 ).

5. The sub-assembly according to any one of the preceding claims, wherein the edge of the opening comprises two cam surfaces inclined in the radial direction to the longitudinal axis and extending closer one another in the proximal direction such that the opening comprises a distal width and a proximal width smaller than the distal width; wherein the protrusion comprises a width being smaller than the proximal width of the opening such that when the protrusion is moved in the proximal direction relative to the opening, the protrusion is guided to move away from the distally directed surface to enable the delivery member guard by the cam surfaces.

6. The sub-assembly according to claim 5, wherein the opening is generally triangular when observes in the radial direction relative to the longitudinal axis.

7. The sub-assembly according to any one of the preceding claims, wherein the delivery member guard comprises a rib extending in the radial direction relative to the longitudinal axis; wherein the rib comprises the distally directed surface.

8. The sub-assembly according to claim 7, wherein the rib of the delivery member guard comprises a proximally directed cam surface19 positioned opposite to the distally directed surface in the direction of the longitudinal axis.

9. The sub-assembly according to any one of the preceding claims, wherein the cap comprises a distally directed surface be in contact with a proximally directed surface of the delivery member guard when the cap is attached to the proximal end of the housing.

10. The sub-assembly according to claim 9, wherein the delivery member guard comprises a first length measured along the longitudinal axis from a proximal end of the delivery member guard to the proximal end of the housing when a tubular proximal section of the delivery member guard is in a fully extended position; wherein a second length is defined between the distally directed surface of the cap and the proximal end of the housing along the longitudinal axis; and wherein the second length is shorter than the first length.11 . The sub-assembly according to any one of the preceding claims, wherein the cap is in contact with the housing via a cam interface such that when the cap is rotated around the longitudinal axis, the cap is guided to move in the direction of the longitudinal axis by the cam interface.

12. The sub-assembly according to any one of the preceding claims, wherein a cut-out is arranged in a wall of the cap; and wherein the cutout is adjacent to the protrusion of the cap.

13. The sub-assembly according to any one of the preceding claims, wherein the housing comprises a slot extending from the opening to the proximal end of the housing.

14. A medicament delivery device comprising the sub-assembly according to any one of the preceding claims.

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