Syringe dampening mechanism

Abstract

An injector includes a housing having a proximal end and a distal end extending along a longitudinal axis, a medicament container disposed at least partially within the housing, a plunger disposed within the medicament container, a ram configured to move the plunger relative to the medicament container, the ram disposed within the housing and moveable relative to the housing between a pre-firing position and a fired position, an energy source configured to move the ram from the pre-firing position to the fired position, and a dampener disposed within the housing and configured to engage the ram to reduce an initial force exerted by the ram on the plunger when the ram is moved from the pre-firing position to the fired position.

Description

Docket No. 063995-01-5127-WOTITLE

[0001] Syringe Dampening MechanismCROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims the benefit of U.S. Provisional Patent Application No. 63 / 696,995 filed September 20, 2024 entitled “Syringe Dampening Mechanism”, which is incorporated by reference herein in its entirety.TECHNICAL FIELD

[0003] The present disclosure generally relates to injectors for administering medicament to a patient and, in some embodiments, to syringe dampening mechanisms for injectors.SUMMARY

[0004] In one embodiment, there is an injector having a housing having a proximal end and a distal end extending along a longitudinal axis, a medicament container disposed at least partially within the housing, a plunger disposed within the medicament container, a ram configured to move the plunger relative to the medicament container, the ram disposed within the housing and moveable relative to the housing between a pre-firing position and a fired position, an energy source configured to move the ram from the pre-firing position to the fired position, and a dampener disposed within the housing and configured to engage the ram to reduce an initial force exerted by the ram on the plunger when the ram is moved from the pre-firing position to the fired position.

[0005] In some embodiments, there is a latch disposed within the housing having a spine defined along a portion thereof, the spine having a notch protruding therefrom, and a slot configured to receive the spine defined along a portion of the ram, the slot having a protrusion protruding therefrom. In some embodiments, the notch temporarily engages the protrusion when the ram is moved from the pre-firing position to the fired position. In some embodiments, the notch engaging the protrusion temporarily inhibits distal movement of the ram relative to the medicament container.

[0006] In some embodiments, a force of the energy source acting on the ram overcomes the engagement of the notch and protrusion to move the ram from the pre-firing position to the fired position. In some embodiments, the ram is spaced apart from the protrusion in the pre-firing position. In some embodiments, the ram is in contact with the plunger when the force of the energy source overcomes the engagement of the notch and protrusion. In some embodiments, the ram moves the plunger relative to the medicament container when the force of the ram overcomes a frictional engagement of the plunger and the medicament container. In some embodiments,engagement of the notch and the slot prevents rotation of the ram relative to the latch when the ram is moved from the pre-firing position to the fired position.

[0007] In some embodiments, there is a latch disposed within the housing, the latch having a latch body configured to receive a proximal end of the ram therein. In some embodiments, at least a portion of the latch body is tapered inward toward a proximal end. In some embodiments, the proximal end of the ram is engaged by the tapered portion of the latch body. In some embodiments, engagement between the ram and the latch body temporarily inhibits distal movement of the ram relative to the medicament container.

[0008] In some embodiments, a force generated by the energy source overcomes the engagement of the ram and the latch body to move the ram from the pre-firing position to the fired position. In some embodiments, the ram is spaced apart from the plunger in the pre-firing position. In some embodiments, the ram is in contact with the plunger when the energy source overcomes the engagement of the ram and the latch body. In some embodiments, the ram moves the plunger relative to the medicament container when the force of the ram overcomes a frictional engagement of the plunger and the medicament container. In some embodiments, the proximal end of the ram is tapered outward toward the proximal end.

[0009] In some embodiments, the distal end of the ram is tapered in toward the distal end. In some embodiments, there is a ram cap disposed at least partially around the distal end of the ram, the ram cap having an interior taper that is generally the same as the taper of the distal end of the ram. In some embodiments, movement of the ram from the pre-firing position to the fired position causes the distal end of the ram to engage the ram cap. In some embodiments, a frictional engagement of the ram and the ram cap temporarily inhibits distal movement of the ram relative to the medicament container. In some embodiments, the ram cap moves the plunger relative to the medicament container when the frictional engagement of the ram and the ram cap overcomes a frictional engagement of the plunger and the medicament container.

[0010] In some embodiments, the ram is spaced apart from the ram cap in the pre-firing position. In some embodiments, the ram cap has at least one slit extending along the longitudinal axis from a proximal end thereof. In some embodiments, a frictional engagement of the ram and the ram cap causes the slit to increase a circumference of the ram cap.

[0011] In some embodiments, there is a dampener body extending from the distal end of the ram, a plunger engagement component moveable relative to the dampener body between an extended position and a compressed position, and a dampener spring configured to urge the plunger engagement component toward the extended position. In some embodiments, the plunger engagement component engages the plunger and is moved from the extended position to thecompressed position by the plunger when the ram is moved from the pre-firing position to the fired position. In some embodiments, the dampener spring temporarily inhibits distal movement of the ram relative to the medicament container as the plunger engagement component is moved from the extended position to the compressed position. In some embodiments, the plunger engagement component moves the plunger relative to the medicament container when the force of the ram and plunger engagement component overcomes a frictional engagement of the plunger and the medicament container.

[0012] In some embodiments, the dampener includes a disc spring disposed on the distal end of the ram, the disc spring moveable between a neutral position and a compressed position. In some embodiments, the disc spring engages the plunger and is moved from the neutral position to the compressed position by the plunger when the ram is moved from the pre-firing position to the fired position. In some embodiments, the disc spring temporarily inhibits distal movement of the ram relative to the medicament container as the disc spring is moved from the neutral position to the compressed position. In some embodiments, the disc spring moves the plunger relative to the medicament container when the force of the ram and disc spring overcomes a frictional engagement of the plunger and the medicament container. In some embodiments, the disc spring is fixed relative to the ram.

[0013] In some embodiments, the dampener further includes a plunger engagement component spaced apart from the distal end of the ram and a wave spring disposed between the plunger engagement component and the distal end of the ram, the wave spring moveable between a neutral position and a compressed position. In some embodiments, the plunger engagement component engages the plunger, and the wave spring is moved from the neutral position to the compressed position when the ram is moved from the pre-firing position to the fired position. In some embodiments, the wave spring temporarily inhibits distal movement of the ram relative to the medicament container as the wave spring is moved from the neutral position to the compressed position. In some embodiments, the plunger engagement component moves the plunger relative to the medicament container when the force of the ram and plunger engagement component overcomes a frictional engagement of the plunger and the medicament container. In some embodiments, the plunger engagement component is generally flush with the distal end of the ram when the wave spring is in the compressed position.

[0014] In some embodiments, the dampener further includes a plunger engagement component spaced apart from the distal end of the ram, the plunger engagement component having an aperture extending therefrom, and a flex tab angled inward to the distal end and extending from the distal end of the ram, the flex tab configured to pass through the aperture of the plunger engagementcomponent. In some embodiments, the flex tab engages the aperture of the plunger engagement component when the ram is moved from the pre-firing position to the fired position. In some embodiments, the engagement of the flex tab and the plunger engagement component temporarily inhibits distal movement of the ram relative to the medicament container. In some embodiments, the plunger engagement component moves the plunger relative to the medicament container when a frictional engagement of the flex tab and plunger engagement component overcomes a frictional engagement of the plunger and the medicament container. In some embodiments, the flex tab extends through the aperture when the ram is in the fired position. In some embodiments, the flex tab is disposed at least partially within the plunger when the ram is in the fired position.

[0015] In some embodiments, the dampener further includes a deformable tip disposed on the distal end of the ram, the deformable tip moveable between a neutral position and a compressed position. In some embodiments, the deformable tip engages the plunger and is moved from the neutral position to the compressed position by the plunger when the ram is moved from the prefiring position to the fired position. In some embodiments, the deformable tip temporarily inhibits distal movement of the ram relative to the medicament container as the deformable tip is moved from the neutral position to the compressed position. In some embodiments, the deformable tip moves the plunger relative to the medicament container when the force of the ram and deformable tip overcomes a frictional engagement of the plunger and the medicament container. In some embodiments, the deformable tip is fixed relative to the ram.BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The foregoing summary, as well as, the following detailed description of embodiments of the dampening mechanism will be better understood when read in conjunction with the appended drawings of exemplary embodiments. It should be understood, however, that the invention is not limited to the precise arrangements and instrumentalities shown.

[0017] In the drawings:

[0018] Fig. 1 is a perspective view of an injector in accordance with a first exemplary embodiment of the present invention;

[0019] Fig. 2 is a perspective view of a dampening mechanism of the injector of Fig. 1;

[0020] Fig. 3 is a cross-sectional view of a latch of the dampening mechanism of Fig. 2;

[0021] Fig. 4 is a front view of a ram of the dampening mechanism of Fig. 2;

[0022] Fig. 5 is a cross-sectional view of the dampening mechanism of Fig. 2;

[0023] Fig. 6 is a cross-sectional view of the dampening mechanism of Fig. 2;

[0024] Fig. 7 is a cross-sectional view of a dampening mechanism in accordance with a second exemplary embodiment of the present invention;

[0025] Fig. 8 is a cross-sectional view of the dampening mechanism of Fig. 7;

[0026] Fig. 9 is a cross-sectional view of a dampening mechanism in accordance with a third exemplary embodiment of the present invention;

[0027] Fig. 10 is a perspective view of the dampening mechanism of Fig. 9 disposed in a medicament container;

[0028] Fig. 11 is a perspective view of the dampening mechanism of Fig. 9;

[0029] Fig. 12 is a cross-sectional view of a dampening mechanism in accordance with a fourth exemplary embodiment of the present invention;

[0030] Fig. 13 is a cross-sectional view of the dampening mechanism of Fig. 12;

[0031] Fig. 14 is a side view of the dampening mechanism of Fig. 12 disposed in a medicament container;

[0032] Fig. 15 is a side view of the dampening mechanism of Fig. 12 disposed in a medicament container;

[0033] Fig. 16 is a cross-sectional view of a dampening mechanism in accordance with a fifth exemplary embodiment of the present invention;

[0034] Fig. 17 is a cross-sectional view of the dampening mechanism of Fig. 16;

[0035] Fig. 18 is a perspective view of the dampening mechanism of Fig. 16;

[0036] Fig. 19 is a perspective view of the dampening mechanism of Fig. 16;

[0037] Fig. 20 is a cross-sectional view of a dampening mechanism in accordance with a sixth exemplary embodiment of the present invention;

[0038] Fig. 21 is a cross-sectional view of the dampening mechanism of Fig. 20;

[0039] Fig. 22 is a side view of the dampening mechanism of Fig. 20;

[0040] Fig. 23 is a side view of the dampening mechanism of Fig. 20;

[0041] Fig. 24 is a cross-sectional view of a dampening mechanism in accordance with a seventh exemplary embodiment of the present invention;

[0042] Fig. 25 is a cross-sectional view of the dampening mechanism of Fig. 24;

[0043] Fig. 26 is a perspective view of the dampening mechanism of Fig. 24;

[0044] Fig. 27 is a perspective view of the dampening mechanism of Fig. 24;

[0045] Fig. 28 is a cross-sectional view of a dampening mechanism in accordance with an eighth exemplary embodiment of the present invention;

[0046] Fig. 29 is a cross-sectional view of the dampening mechanism of Fig. 28;

[0047] Fig. 30 is a side view of the dampening mechanism of Fig. 28 disposed in a medicament container;

[0048] Fig. 31 is a side view of the dampening mechanism of Fig. 28 disposed in a medicament container;

[0049] Fig. 32 is a cross-sectional view of a dampening mechanism in accordance with a ninth exemplary embodiment of the present invention;

[0050] Fig. 33 is a cross-sectional view of the dampening mechanism of Fig. 32;

[0051] Fig. 34 is a perspective view of the dampening mechanism of Fig. 32; and

[0052] Fig. 35 is a perspective view of the dampening mechanism of Fig. 32.DETAILED DESCRIPTION

[0053] Injectors are useful devices for delivering medicament to a patient with both precision and efficiency. These injectors often utilize a compressed spring mechanism to deliver the medicament quickly and consistently, ensuring an accurate dosage. Spring-powered injectors are designed to allow patients to administer their own injections and are particularly beneficial in the administration of vaccines, insulin, and other medications that require regular and precise dosing.

[0054] One of the primary limitations of spring-powered injectors is the risk of syringe breakage. This issue often arises when the ram engages the plunger too quickly or with excessive force. The abrupt or forceful engagement can cause the syringe to crack or shatter. This problem is particularly prevalent in high-force injectors designed to deliver viscous medications or larger doses, where the spring force is high, resulting in an elevated degree of mechanical stress on the syringe. Such incidents not only compromise the integrity of the injection but also lead to potential contamination and injury. As such, there is a need for an injector that reduces or eliminates this syringe breakage during the high mechanical stresses of an injection.

[0055] Referring to the drawings in detail, wherein like reference numerals indicate like elements throughout, there is shown in Figs. 1-6 an injector, generally designated 110, in accordance with a first exemplary embodiment of the present invention.

[0056] The injector 110 may include a housing 112, a medicament container 114, a plunger 116, a ram 101, and an energy source 120. As shown in Fig. 1, the housing 112 may have a proximal end and a distal end extending along a longitudinal axis LA. The housing 112 may be configured to allow a user to grip or handle the injector 110. The housing 112 may be shaped to fit into a user’s hand for single-handed function. The housing 112 may have a generally circular cross-section. In some embodiments, the housing 112 has an oval cross-section to help position the injector 110 in the user’shand. The housing 112 may substantially house the components described herein and shown in Figs. 2-6.

[0057] As shown in Fig. 1 , the medicament container 114 may be at least partially disposed within the housing 112. The medicament container 114 may be fixed relative to the housing 112. The medicament container 114 may contain a volume of a medicament therein. The medicament container 114 has a distal portion and a proximal portion opposite the distal portion. As used herein, the medicament may comprise drugs, biologies, solutions, gels, suspensions, or other substances that may be delivered via a syringe or needle, and such terms may be used interchangeably as appearing in the specification and claims. The medicament container 114 may be a prefilled syringe. In other embodiments, the medicament container 114 may be an insertable medicament cartridge. In some embodiments, the medicament container 114 may be filled using a vial and needle or other appropriate filling method. In one embodiment, the medicament container 114 is one of a prefilled cartridge, prefilled staked-needle syringe, vial, or other injectable fluid-containing vessel.

[0058] As shown in Fig. 1, the medicament container 114 may have a port 115 extending from the distal portion. The port 115 may be shaped and sized to receive a delivery accessory therein. In an out-of-box state, the port 115 may receive a plug 117 therein to prevent the medicament from unintentionally escaping the medicament container 114. When ready for use, a user may remove the plug 117 from the port 115 and couple a needle 113 (not shown) thereto. The needle 113 may be in fluid communication with the medicament container 114 to deliver the medicament to a sub-skin location of a subject. In some embodiments, the port 115 receives a luer set or other tubing to facilitate the flow of the medicament to a needle 113 in fluid communication therewith.

[0059] As shown in Fig. 1 , the injector 110 may include a user-operable trigger 119 disposed thereon. The trigger 119 may be moveable relative to the housing 112 to initiate a firing to expel the medicament from the medicament container 114. The trigger 119 may be a button disposed at a proximal portion of the housing 112. In some embodiments, the trigger 119 is a needle guard that extends from a distal portion of the housing 112. In some embodiments, the trigger 119 is a button on the housing. The trigger 119 may interact with other components of the injector 110 to allow the energy source 120 to move the ram 101 and plunger 116 through the medicament container 114, as described in more detail below.

[0060] As shown throughout the figures, the plunger 116 may be disposed within the medicament container 114. The plunger 116 may be moveable within the medicament container 114 along a longitudinal axis LA. Prior to triggering the injector 110, the plunger 116 may be disposed within the medicament container 114 proximate the distal portion thereof. The plunger 116 may seal the medicament in the medicament container 114. The plunger 116 may be generally cylindrical andmade of a rubber material. In some embodiments, the plunger 116 is made of a plastic, butyl rubber, polyisoprene, polytetrafluorethylene, high-density polyethylene, or other thermoset elastomers.

[0061] As shown throughout the figures, the ram 101 may be disposed within the housing 112 and may be moveable relative to the housing 112 between a pre-firing position and a fired position. The ram 101 may be a generally cylindrical member extending along the longitudinal axis LA. The ram 101 may have a proximal end and a distal end opposite the proximal end. The distal end of the ram 101 may be configured to engage the plunger 116 when the ram 101 is moved relative to the housing112 from the pre-firing position to the fired position. The ram 101 may be configured to move the plunger 116 relative to the medicament container 114. The distal end of the ram 101 may be disposed in the medicament container 114 in the fired position. In some embodiments, the distal end of the ram 101 is disposed in the medicament container 114 in the pre-firing position.

[0062] The energy source 120 may be configured to move the ram 101 relative to the housing 112 from the pre-firing position to the fired position. The energy source 120 may be configured to urge the ram 101 distally along the longitudinal axis LArelative to the housing 112. As shown throughout the figures, energy source 120 may be disposed at least partially within the ram 101. The energy source 120 may be disposed between the ram 101 and the distal end of the housing 112. A proximal end of the energy source 120 may engage the housing 112. A distal end of the energy source 120 may engage the distal end of the ram 101. In some embodiments, energy source 120 includes a compression spring; however, another suitable energy source can be used, such as an electric pump, an elastomer or compressed-gas spring, a gas generator, or other suitable energy storage members.

[0063] As shown throughout the figures, the injector 110 may include a dampener 122 disposed within the housing 1 12. As described in more detail below, the dampener 122 may be configured to engage the ram 101 to reduce an initial force exerted on the plunger 116 by the ram 101 when the ram 101 is moved relative to the housing 112 from the pre-firing position to the fired position. This controlled deceleration or inhibition can reduce the mechanical stress exerted on the medicament container 114, thereby minimizing the risk of breakage. The dampener 122 can enhance the safety and reliability of the injector 110, ensuring a smoother and more controlled drug-delivery process. Engagement of the ram 101 and plunger 116 may produce a noise that is disruptive or unsettling to the user. In some embodiments, the dampener 122 reduces the noise associated with the engagement of the ram 101 and plunger 116. Further, engagement of the ram 101 and plunger 116 may cause unintended movement of the medicament container 114 relative to the housing 112. When a needle113 is coupled to the distal end of the medicament container 114, movement of the medicament container 114 relative to the housing can cause the risk of needle stick and injury. The dampener 122may reduce the occurrence of movement of the medicament container 114 relative to the housing 112 when the ram 101 engages the plunger 116.

[0064] As shown in Figs. 2-6, there is a first exemplary embodiment of the dampener 122 of the injector 110. Dampener 122 may include a latch 124 disposed within the housing 112. The latch 124 may be fixed relative to the housing 112 and may be configured to engage the ram 101 as the ram 101 is moved relative to the housing 112 from the pre-firing position to the fired position. The latch 124 may include a collar 142 configured to engage the housing 112 to couple the latch 124 to the housing 112. The latch 124 may be a generally cylindrical member with a latch body 126 extending along the longitudinal axis LA. The latch 124 may have a spine 128 defined along a portion of the latch body 126. In some embodiments, the spine 128 extends along the entire latch 124. The spine 128 may extend along the longitudinal axis LA. The spine 128 may extend from the latch body 126. The latch body 126 may include two spines 128. The two spines 128 may be spaced apart and parallel to one another.

[0065] The latch body 126 may include at least one flexible arm 136 defined thereon. The flexible arm 136 may extend along the longitudinal axis LAand may be moveable relative to the latch body 126 between an initial position and a released position. The flexible arm 136 may include an engagement component 138 extending therefrom configured to prevent movement of the ram 101 relative to the latch 124. The ram 101 may include a ram aperture 140 extending therethrough. The ram aperture 140 may be shaped and sized to receive the engagement component 138 of the latch 124 therein. The housing 112 or another component of the injector 110 may prevent the flexible arm 136 from moving relative to the latch body 126 from the initial position to the released position prior to an intended triggering of the injector 110. During a firing, the flexible arm 136 is allowed to move relative to the latch body 126 to the released position to disengage the engagement component 138 and the ram aperture 140 thereby allowing the energy source 120 to move the ram 101 relative to the housing 112.

[0066] As shown in Figs. 5-6, the spine 128 may have a notch 130 protruding therefrom. The notch 130 may be a deformable member that extends from the spine 128. The notch 130 may be angled relative to the spine 128 toward the distal end of the injector 110. The notch 130 may be moveable relative to the spine 128 between an extended position and a retracted position. The notch 130 may be configured to return to the extended position after being moved relative to the spine 128 to the retracted position. The notch 130 may protrude from the spine 128 in the retracted position. In some embodiments, the notch 130 is a rigid member. The number, dimensions, and locations of the notch 130 are variable and can be adjusted according to the specific requirements of the injector 110.

[0067] The ram 101 may be sized and shaped to be disposed within the latch 124. The ram 101 may have a slot 132 defined along a portion thereof. In some embodiments, the slot 132 extends along the entire ram 101. The slot 132 may extend into the ram 101. The ram 101 may include two slots 132. The two slots 132 may be spaced apart and parallel to one another. The slot 132 may include a protrusion 134 protruding from the slot 132. The protrusion 134 may be a rigid member. The protrusion 134 may be a rounded member. In some embodiments, the protrusion 134 is angled or squared relative to the slot 132. The number, dimensions, and locations of the protrusion 134 are variable and can be adjusted according to the specific requirements of the injector 110.

[0068] As shown in Figs. 5-6, the slot 132 may be configured to receive the spine 128 at least partially therein. In some embodiments, the slot 132 is on the latch 124 and the spine 128 is on the ram 101. The spine 128 being received in the slot 132 may prevent rotation of the ram 101 relative to the latch 124 when the trigger 119 releases the ram 101 and the ram 101 is moved relative to the housing 112 from the pre-firing position to the fired position. The notch 130 and the protrusion 134 may be spaced apart when the ram 101 is in the pre-firing position. In some embodiments, the notch 130 and the protrusion 134 are proximate or in contact when the ram 101 is in the pre-firing position. The energy source 120 moving the ram 101 relative to the housing 112 from the pre-firing position toward the fired position may cause the protrusion 134 to engage the notch 130.

[0069] The notch 130 may be configured to temporarily engage the protrusion 134 when the ram 101 is moved relative to the housing 112 from the pre-firing position to the fired position. Engagement of the notch 130 and the protrusion 134 may move the notch 130 relative to the spine 128 from the extended position to the retracted position. The notch 130 engaging the protrusion 134 may temporarily inhibit distal movement of the ram 101 relative to the medicament container 114.

[0070] The force of the energy source 120 acting on the ram 101 may overcome the engagement of the protrusion 134 and the notch 130 to move the ram 101 relative to the housing 112 to the fired position. The force required to overcome the interference between the protrusion 134 and the notch 130 may initially be greater than the force of the energy source 120 acting on the ram 101. As the ram 101 continues to move distally along the longitudinal axis LA, the required force to move the notch 130 relative to the spine 128 into the retracted position and pass the protrusion 134 over the notch 130 increases progressively. The increase in force may ensure that the engagement between the ram 101 and the latch 124 remains secure until the notch 130 is fully moved relative to the spine 128 into the retracted position.

[0071] When the notch 130 is fully moved relative to the spine 128 into the retracted position, the distal end of the ram 101 may come into contact with the plunger 116. At this point, the force of the energy source 120 is transferred to the plunger 116. The ram 101 may move the plunger 116 relativeto the medicament container 114 when the force of the ram 101 overcomes a frictional engagement of the plunger 116 and the medicament container 114. As shown in Fig. 5, the ram 101 may be spaced apart from the plunger 1 16 in the pre-firing position. In some embodiments, the ram 101 is in contact with the plunger 116 when the ram 101 is in the pre-firing position. As shown in Fig. 6, the ram 101 may be in contact with the plunger 116 when the force of the energy source 120 overcomes the engagement of the notch 130 and protrusion 134.

[0072] As shown in Figs. 7-8, there is a second exemplary embodiment of the dampener of the injector 210, hereinafter referred to as dampener 222. Dampener 222 may include a latch 224 disposed within the housing 212. The latch 224 may be fixed relative to the housing 212 and may be configured to engage the ram 226 as the ram 226 is moved relative to the housing 212 from the pre-firing position to the fired position. The latch 224 may include a collar 228 configured to engage the housing 212 to couple the latch 224 to the housing 212.

[0073] As shown in Figs. 7-8, the latch 224 may be a generally cylindrical member with a latch body 230 extending along the longitudinal axis LA. The latch body 230 may have a proximal end and a distal end opposite the proximal end. At least a portion of the latch body 230 may be tapered inward. The latch body 230 may be tapered inward toward the proximal end. For example, a circumference of the latch body 230 at the proximal end may be less than the circumference of the latch body 230 at the distal end. In some embodiments, only a portion of the latch body 230 proximate the proximal end is tapered inward.

[0074] The taper of the latch body 230 may be approximately 0.25°. In some embodiments, the taper of the latch body 230 is approximately 0.25°, approximately 0.5°, approximately 0.75°, approximately 1°, approximately 1.25°, approximately 1.5°, approximately 1.75°, approximately 2°, approximately 2.25°, approximately 2.5°, approximately 2.75°, approximately 3°, approximately 3.25°, approximately 3.5°, approximately 3.75°, approximately 4°, approximately 4.25°, approximately 4.5°, approximately 4.75°, or approximately 5°. In some embodiments, the taper of the latch body 230 is at least 0.25°, at least 0.5°, at least 0.75°, at least 1°, at least 1.25°, at least 1.5°, at least 1.75°, at least 2°, at least 2.25°, at least 2.5°, at least 2.75°, at least 3°, at least 3.25°, at least 3.5°, at least 3.75°, at least 4°, at least 4.25°, at least 4.5°, at least 4.75°, or at least 5°. In some embodiments, the taper of the latch body 230 is between approximately 0.25° and 5°, between approximately 0.5° and 4.75°, between approximately 0.75° and 4.5°, between approximately 1° and 4.25°, between approximately 1.25° and 4°, between approximately 1.5° and 3.75°, between approximately 1.75° and 3.5°, between approximately 2° and 3.25°, between approximately 2.25° and 3.5°, or between approximately 2.25° and 3°.

[0075] As shown in Figs. 7-8, the ram 226 may be a generally cylindrical member with a ram body 232 extending along the longitudinal axis LA. The ram body 232 may have a proximal end and a distal end opposite the proximal end. At least a portion of the ram body 232 may be tapered outward. The ram body 232 may be tapered outward toward the proximal end. For example, a circumference of the ram body 232 at the proximal end may be greater than the circumference of the ram body 232 at the distal end. In some embodiments, only a portion of the ram body 232 proximate the proximal end is tapered outward.

[0076] The taper of the ram body 232 may be approximately 0.25°. In some embodiments, the taper of the ram body 232 is approximately 0.25°, approximately 0.5°, approximately 0.75°, approximately 1°, approximately 1.25°, approximately 1.5°, approximately 1.75°, approximately 2°, approximately 2.25°, approximately 2.5°, approximately 2.75°, approximately 3°, approximately 3.25°, approximately 3.5°, approximately 3.75°, approximately 4°, approximately 4.25°, approximately 4.5°, approximately 4.75°, or approximately 5°. In some embodiments, the taper of the ram body 232 is at least 0.25°, at least 0.5°, at least 0.75°, at least 1°, at least 1.25°, at least 1.5°, at least 1.75°, at least 2°, at least 2.25°, at least 2.5°, at least 2.75°, at least 3°, at least 3.25°, at least 3.5°, at least 3.75°, at least 4°, at least 4.25°, at least 4.5°, at least 4.75°, or at least 5°. In some embodiments, the taper of the ram body 232 is between approximately 0.25° and 5°, between approximately 0.5° and 4.75°, between approximately 0.75° and 4.5°, between approximately 1° and 4.25°, between approximately 1.25° and 4°, between approximately 1.5° and 3.75°, between approximately 1.75° and 3.5°, between approximately 2° and 3.25°, between approximately 2.25° and 3.5°, or between approximately 2.25° and 3°.

[0077] As shown in Figs. 7-8, the latch body 230 may be configured to receive the ram 226 therein. The latch body 230 may receive the proximal end of the ram body 232 therein. The circumference of the proximal end of the latch body 230 may be smaller than the circumference of the proximal end of the ram body 232. The proximal end of the ram body 232 may be engaged by the tapered portion of the latch body 230. This engagement may create a frictional fit between the ram 226 and the latch 224. In some embodiments, the latch body 230 is tapered inward and the ram body 232 is generally cylindrical. In some embodiments, the ram body 232 is tapered outward and the latch body 230 is generally cylindrical.

[0078] This engagement between the ram 226 and the latch 224 may temporarily inhibit distal movement of the ram 226 relative to the medicament container 214 when the trigger 219 releases the ram 226 and the ram 226 is moved relative to the housing 212 from the pre-firing position to the fired position. A force generated by the energy source 220 may overcome the engagement of the ram 226 and the latch 224 to move the ram 226 relative to the housing 212 from the pre-firing position to thefired position. The force required to overcome the engagement of the ram 226 and the latch 224 may be less than the force of the energy source 220 acting on the ram 226. As the ram 226 continues to move distally relative to the housing 212 along the longitudinal axis LA, the required force to move the ram 226 relative to the latch 224 may decrease progressively.

[0079] When the proximal end of the ram 226 is positioned distally of the tapered portion of the latch body 230, the ram 226 may be freely moveable relative to the latch 224. The ram 226 may move the plunger 216 relative to the medicament container 214 when the force of the ram 226 overcomes the frictional engagement of the plunger 216 and the medicament container 214. As shown in Fig. 7, the ram 226 may be spaced apart from the plunger 216 in the pre-firing position. As shown in Fig. 8, the ram may be in contact with the plunger 216 when the energy source 220 overcomes the engagement of the ram 226 and the latch 224. In some embodiments, the ram 226 is in contact with the plunger 216 when the ram 226 is in the pre-firing position.

[0080] Referring to Figs. 9-11, there is shown a third exemplary embodiment of the dampener of the injector 310, hereinafter referred to as dampener 322. Dampener 322 may include a latch 324, a ram 326 and a ram cap 328 disposed within the housing 312. The latch 324 may be fixed relative to the housing 312. The latch 324 may include a collar 330 configured to engage the housing 312 to couple the latch 324 to the housing 312. The latch 324 may be a generally cylindrical member extending along the longitudinal axis LA. The latch 324 may have a proximal end and a distal end opposite the proximal end. The distal end of the latch 324 may be sized and shaped to receive at least a portion of the ram 326 therein.

[0081] As shown in Figs. 9-11, the ram 326 may be a generally cylindrical member extending along the longitudinal axis LA. The ram 326 may have a proximal end and a distal end opposite the proximal end. The distal end of the ram 326 may be tapered in toward the distal end. For example, a circumference of the distal end of the ram 326 may be smaller than a circumference of a portion of the ram 326 that is spaced apart from the distal end. Only a portion of the ram 326 may be tapered. In some embodiments, the ram 326 is tapered from the proximal end to the distal end.

[0082] The taper of the ram 326 may be approximately 1°. In some embodiments, the taper of the ram 326 is approximately 1°, approximately 1.25°, approximately 1.5°, approximately 1.75°, approximately 2°, approximately 2.25°, approximately 2.5°, approximately 2.75°, approximately 3°, approximately 3.25°, approximately 3.5°, approximately 3.75°, approximately 4°, approximately 4.25°, approximately 4.5°, approximately 4.75°, or approximately 5°. In some embodiments, the taper of the ram 326 is at least 1°, at least 1.25°, at least 1.5°, at least 1.75°, at least 2°, at least 2.25°, at least 2.5°, at least 2.75°, at least 3°, at least 3.25°, at least 3.5°, at least 3.75°, at least 4°, at least 4.25°, at least 4.5°, at least 4.75°, or at least 5°. In some embodiments, the taper of the ram 326 is betweenapproximately 1° and 5°, between approximately 1.25° and 4.75°, between approximately 1.5° and 4.5°, between approximately 1.75° and 4.25°, between approximately 2° and 4°, between approximately 2.25° and 3.75°, between approximately 2.5° and 3.5°, or between approximately 2.75° and 3.25°.

[0083] As shown in Figs. 9-11, the ram cap 328 may be disposed at least partially around the distal end of the ram 326. The ram cap 328 may be a generally cylindrical member extending along the longitudinal axis LA. The ram cap 328 may have a proximal end and a distal end opposite the proximal end. The proximal end of the ram cap 328 may be open and the distal end may be closed. The ram cap 328 may include at least one slit 332 extending along the longitudinal axis LAfrom a proximal end thereof. The slit 332 may extend partially from the proximal end to the distal end. In some embodiments, the slit 332 extends from the proximal end to the distal end. The slit 332 may allow the ram cap 328 to flex radially outward in response to engagement with the ram 326, as described below. In some embodiments, the ram cap 328 is a rigid member.

[0084] An internal surface of the ram cap 328 may be tapered in toward the distal end. The taper of the ram cap 328 may be generally the same as the taper of the distal end of the ram 326. In some embodiments, the taper of the ram cap 328 is greater than the taper of the distal end of the ram 326.

[0085] The taper of the ram cap 328 may be approximately 1°. In some embodiments, the taper of the ram cap 328 is approximately 1°, approximately 1.25°, approximately 1.5°, approximately 1.75°, approximately 2°, approximately 2.25°, approximately 2.5°, approximately 2.75°, approximately 3°, approximately 3.25°, approximately 3.5°, approximately 3.75°, approximately 4°, approximately 4.25°, approximately 4.5°, approximately 4.75°, or approximately 5°. In some embodiments, the taper of the ram cap 328 is at least 1 °, at least 1 .25°, at least 1 .5°, at least 1 .75°, at least 2°, at least 2.25°, at least 2.5°, at least 2.75°, at least 3°, at least 3.25°, at least 3.5°, at least 3.75°, at least 4°, at least 4.25°, at least 4.5°, at least 4.75°, or at least 5°. In some embodiments, the taper of the ram cap 328 is between approximately 1° and 5°, between approximately 1.25° and 4.75°, between approximately 1.5° and 4.5°, between approximately 1.75° and 4.25°, between approximately 2° and 4°, between approximately 2.25° and 3.75°, between approximately 2.5° and 3.5°, or between approximately 2.75° and 3.25°.

[0086] The proximal end of the ram cap 328 may be shaped and sized to receive the distal end of the ram 326 therein. The circumference of the distal end of the ram 326 may be larger than a circumference of the proximal end of the ram cap 328. The distal end of the ram 326 may be engaged by the ram cap 328. In some embodiments, the ram 326 or the ram cap 328 is tapered and the other is generally cylindrical. The frictional engagement of the ram 326 and the ram cap 328 may cause the slit 332 to increase the circumference of the ram cap 328.

[0087] During assembly of the injector 310, the distal end of the ram 326 may be inserted in the ram cap 328. In some embodiments, movement of the ram 326 relative to the housing 312 from the pre-firing position to the fired position causes the distal end of the ram 326 to engage the ram cap 328. When the trigger 319 releases the ram 326 and the ram 326 is moved relative to the housing 312 from the pre-firing position to the fired position, the ram cap 328 may engage the plunger 316. The frictional force between the plunger 316 and the medicament container 314 may be greater than the initial frictional force between the ram 326 and the ram cap 328.

[0088] As the ram 326 is moved relative to the housing 312 from the pre-firing position to the fired position, the ram cap 328 may be prevented from moving distally relative to the housing 312 by the plunger 316. The distal end of the ram 326 may be moved distally relative to the ram cap 328 when the ram cap 328 is prevented from moving distally relative to the housing 312 by the plunger 316. The tapered portion of the ram 326 may be engaged by the tapered portion of the ram cap 328. The frictional engagement of the ram 326 and the ram cap 328 may temporarily inhibit distal movement of the ram 326 relative to the housing 312 and relative to the medicament container 314. In some embodiments, the frictional engagement of the ram 326 and the ram cap 328 slows the distal movement of the ram 326 relative to the medicament container 314. The frictional engagement of the ram 326 and the ram cap 328 may temporarily inhibit distal movement of the ram cap 328 relative to the housing 312 relative to the medicament container 314 as the ram 326 moves distally relative to the ram cap 328. As the energy source 320 urges the ram 326 distally relative to the ram cap 328, the frictional force between the ram 326 and the ram cap 328 may increase. This engagement may create a frictional fit between the ram 326 and the ram cap 328.

[0089] When the frictional force between the ram 326 and the ram cap 328 is greater than the frictional force between the plunger 316 and the medicament container 314, force of the energy source 320 may act on the plunger 316 and the ram 326 may urge the plunger 316 distally relative to the medicament container 314. The ram 326 and the ram cap 328 may act as a single component acting on the plunger 316 when the frictional force between them overcomes the frictional force between the plunger 316 and the medicament container 314. The ram cap 328 may move the plunger 316 relative to the medicament container 314 when the frictional engagement of the ram 326 and the ram cap 328 overcomes a frictional engagement of the plunger 316 and the medicament container 314. As shown in Fig. 9, the ram cap 328 may be spaced apart from the plunger 316 when the ram 326 is in the prefiring position. In some embodiments, the ram cap 328 is in contact with the plunger 316 when the ram 326 is in the pre-firing position.

[0090] As shown in Figs. 12-15, there is a fourth exemplary embodiment of the dampener of the injector 410, hereinafter referred to as dampener 422. Dampener 422 may include a ram 426, adampener body 428 extending from the ram 426, a plunger engagement component 430 moveable relative to the dampener body 428, and a dampener spring 432 disposed between the dampener body and the plunger engagement component. The ram 426 may be a generally cylindrical member extending along the longitudinal axis LA. The ram 426 may have a proximal end and a distal end opposite the proximal end.

[0091] As shown in Figs. 12-15, the dampener body 428 may extend from the distal end of the ram 426. The dampener body 428 may be integrally formed with the ram 426. In some embodiments, the dampener body 428 is coupled to the distal end of the ram 426. The dampener body 428 may be a generally cylindrical member extending along the longitudinal axis LA. The dampener body 428 may have a circumference substantially similar to a circumference of the ram 426. The distal end of the dampener body 428 may be open and the proximal end of the dampener body 428 may be closed. The distal end of the dampener body 428 may include a lip 434 defined thereon. The lip 434 may extend radially inward from the distal end of the dampener body 428. The lip 434 may extend around the circumference of the dampener body 428. In some embodiments, the lip 434 extends around only a portion of the dampener body 428.

[0092] As shown in Figs. 12-15, the dampener body 428 may be shaped and sized to receive the plunger engagement component 430 and the dampener spring 432 at least partially therein. The plunger engagement component 430 may be a generally cylindrical member extending along the longitudinal axis LA. The plunger engagement component 430 may have a proximal end and a distal end opposite the proximal end. The proximal end of the plunger engagement component 430 may be open and the distal end may be closed. The proximal end of the plunger engagement component 430 may be shaped and sized to allow the dampener spring 432 to pass therethrough.

[0093] As shown in Figs. 12-15, the plunger engagement component 430 may be moveable relative to the dampener body 428 between an extended position and a compressed position. The distal end of the plunger engagement component 430 may be spaced apart from the distal end of the dampener body 428 in the extended position. The distal end of the plunger engagement component 430 may be substantially flush with the distal end of the dampener body 428 in the compressed position. In some embodiments, the distal end of the plunger engagement component 430 is a further distance from the distal end of the dampener body 428 in the extended position than the compressed position.

[0094] As shown in Figs. 12-15, the dampener spring 432 may be configured to urge the plunger engagement component 430 relative to the dampener body 428 toward the extended position. The dampener spring 432 may urge the plunger engagement component 430 relative to the dampener body 428 toward the extended position before the trigger 419 releases the ram 426. The dampener spring432 may engage the proximal end of the dampener body 428 and the distal end of the plunger engagement component 430. The distal end of the plunger engagement component 430 may have a collar 436 defined thereon. The collar 436 may extend radially outward from the distal end of the plunger engagement component 430. The collar 436 may engage the lip 434 of the dampener body 428 to prevent the plunger engagement component 430 and the dampener body 428 from separating. The lip 434 may prevent the dampener spring 432 from urging the proximal end of the plunger engagement component 430 distally past the distal end of the dampener body 428. During assembly of the injector 410, the plunger engagement component 430 may be inserted into the dampener body 428. Although it is shown in the figures that the plunger engagement component 430 is received in the dampener body 428, in certain embodiments the dampener body 428 can be received in the plunger engagement component 430.

[0095] When the trigger 419 releases the ram 426 and the ram 426 is moved relative to the housing 412 from the pre-firing position to the fired position, the distal end of the plunger engagement component 430 may engage the plunger 416. The frictional force between the plunger 416 and the medicament container 414 may be greater than the initial force of the dampener spring 432 acting on the plunger engagement component 430. The engagement between the plunger engagement component 430 and the plunger 416 may force the plunger engagement component 430 to move relative to the dampener body 428 from the extended position toward the compressed position when the ram 426 is moved relative to the housing 412 from the pre-firing position to the fired position. The dampener spring 432 may act upon the dampener body 428 as the plunger engagement component 430 is moved relative to the dampener body 428 toward the compressed position. The dampener spring 432 may temporarily inhibit distal movement of the plunger 416 relative to the medicament container 414 and may temporarily slow the distal movement of the ram 426 relative to the medicament container 414 as the plunger engagement component 430 is moved relative to the dampener body 428 from the extended position to the retracted position.

[0096] When the plunger engagement component 430 is in the retracted position, the energy source 420 may overcome the frictional force between the plunger 416 and the medicament container 414 and cause the ram 426 to urge the plunger 416 distally relative to the medicament container 414. The ram 426 and the plunger engagement component 430 may act as a single component acting on the plunger 416 when the plunger engagement component 430 is in the retracted position. The plunger engagement component 430 may move the plunger 416 relative to the medicament container 414 when the force of the ram 426 and the plunger engagement component 430 overcomes a frictional engagement of the plunger 416 and the medicament container 414. As shown in Fig. 12, the plunger engagement component 430 may be spaced apart from the plunger 416 when the ram 426 is in thepre-firing position. In some embodiments, the plunger engagement component 430 is in contact with the plunger 416 when the ram 426 is in the pre-firing position.

[0097] As shown in Figs. 16-19, there is a fifth exemplary embodiment of the dampener of the injector 510, hereinafter referred to as dampener 522. Dampener 522 may include a ram 524 and a disc spring 526 disposed thereon. The ram 524 may be a generally cylindrical member extending along the longitudinal axis LA. The ram 524 may have a proximal end and a distal end opposite the proximal end. The ram 524 may include a rim 528 extending distally from the distal end thereof. The rim 528 may extend around a circumference of the distal end of the ram 524. In some embodiments, the rim 528 extends around a portion of the distal end of the ram 524. The rim 528 may be shaped and sized to receive the disc spring 526 therein, as described in more detail below.

[0098] As shown in Figs. 16-19, the disc spring 526 may be coupled to the distal end of the ram 502 to prevent the disc spring 526 from moving out of its intended place before or during use. The ram 524 may have a groove 530 defined in the distal end thereof. The groove 530 may extend proximally into the distal end of the ram 524 and may be shaped and sized to receive the disc spring 526 therein. The groove 530 may be a recess. The groove 530 may be defined by the rim 528 on an outer edge and at least one tab 532 on an inner edge. The tab 532 may extend radially outward from the inner edge of the groove 530. The tab 532 may extend distally from the inner edge of the groove 530. The tab 532 may be configured to receive the disc spring 526 thereunder to couple the disc spring 526 to the ram 524. There may be a plurality of tabs 532 spaced apart around the groove 530. The tab 532 may prevent the disc spring 526 from rotating relative to the ram 524. The disc spring 526 may be fixed relative to the ram 524.

[0099] The disc spring 526 may be moveable relative to the distal end of the ram 524 between a neutral position (Figs. 16, 18) and a compressed position (Figs. 17, 19). The disc spring 526 may be configured to deflect under a load. The disc spring 526 may include a plurality of disc springs coupled to each other. In some embodiments, the disc spring 526 is a single disc spring. In some embodiments, the disc spring is one of a wave disc spring, coil spring, wave spring, leaf spring, or other spring that is able to deflect under a load. The disc spring may extend distally from the groove 530 in the neutral position and may be substantially flush with the distal end of the ram 524 in the compressed position.

[0100] As shown in Figs. 16-19, when the trigger 519 releases the ram 524 and the ram 524 is moved relative to the housing 512 from the pre-firing position to the fired position, the disc spring 526 may engage the plunger 516. The frictional force between the plunger 516 and the medicament container 514 may be greater than the initial force of the disc spring 526 acting on the plunger 516. The engagement between the plunger 516 and the disc spring 526 may force the disc spring 526 to move relative to the distal end of the ram 524 from the neutral position to the compressed positionwhen the ram 524 is moved relative to the housing 512 from the pre-firing position to the fired position. The disc spring 526 may act on the ram 524 as the disc spring 526 is moved toward the compressed position. The disc spring 526 may temporarily inhibit distal movement of the plunger 516 relative to the medicament container 514 and may temporarily slow the distal movement of the ram 524 relative to the medicament container 514 as the disc spring 526 is moved from the neutral position to the compressed position.

[0101] When the disc spring 526 is in the compressed position, the energy source 520 may overcome the frictional force between the plunger 516 and the medicament container 514 and cause the ram 524 to urge the plunger 516 distally relative to the medicament container 514. The ram 524 and the disc spring 526 may act as a single component acting on the plunger 516 when the disc spring 526 is in the compressed position. The disc spring 526 may move the plunger 516 relative to the medicament container 514 when the force of the ram 524 and the disc spring 526 overcomes a frictional engagement of the plunger 516 and the medicament container 514. As shown in Fig. 16, the disc spring 526 may be in contact with the plunger 516 when the ram 524 is in the pre-firing position. In some embodiments, the disc spring 526 is spaced apart from the plunger 516 when the ram 524 is in the pre-firing position.

[0102] As shown in Figs. 20-23, there is shown a sixth exemplary embodiment of the dampener of the injector 610, hereinafter referred to as dampener 622. Dampener 622 may include a ram 624, a plunger engagement component 626 spaced apart from the ram 624, and a wave spring 628 disposed between the plunger engagement component 626 and the ram 624. The ram 624 may be a generally cylindrical member extending along the longitudinal axis LA. The ram 624 may have a proximal end and a distal end opposite the proximal end. The plunger engagement component 626 may be spaced apart from the distal end of the ram 624. The wave spring 628 may be disposed between the plunger engagement component 626 and the distal end of the ram 624.

[0103] As shown in Figs. 20-23, the distal end of the ram 624 may have a ram recess 630 defined therein. The ram recess 630 may extend around a circumference of the distal end of the ram 624 and may be shaped and sized to receive at least a portion of the wave spring 628 therein. In some embodiments, the ram recess 630 may be shaped and sized to receive the entire wave spring 628 therein. The distal end of the ram 624 may have an aperture 632 extending therethrough. There may be two apertures 632 extending through the distal end of the ram 624. The aperture 632 may be configured to receive a portion of the plunger engagement component 626 to couple the plunger engagement component 626 to the ram 624, as described in more detail below.

[0104] As shown in Figs. 20-23, the plunger engagement component 626 may be a generally circular member having a proximal side and a distal side opposite the proximal side. The proximalside of the plunger engagement component 626 may have a groove 634 defined therein. The groove 634 may be complimentary to the ram recess 630 and may have substantially similar shapes. The groove 634 may be configured to receive at least a portion of the wave spring 628 therein. In some embodiments, the groove 634 is configured to receive the entire wave spring 628 therein. The plunger engagement component 626 may be slidably coupled to the ram 624 and may be moveable relative to the distal end of the ram 624 between an extended position and a retracted position. The plunger engagement component 626 may be spaced apart from the ram 624 in the extended position. The plunger engagement component 626 may be in contact with the ram 624 in the retracted position. The proximal side of the plunger engagement component 626 may be in contact with the distal end of the ram 624 in the retracted position.

[0105] As shown in Figs. 20-23, the plunger engagement component 626 may include a flexible arm 636 extending from the proximal side thereof. The flexible arm 636 may be shaped and sized to pass through the aperture 632. The plunger engagement component 626 may include two flexible arms 636 extending therefrom. The flexible arm 636 may include a tab 638 extending therefrom. The tab 638 may extend radially outward from an end of the flexible arm 636 opposite the end that is fixed to the plunger engagement component 626. The flexible arm 636 may be configured to flex radially inward when the tab 638 passes through the aperture 632 and the flexible arm 636 may flex radially outward when the tab 638 has passed through the aperture 632. The tab 638 may couple the flexible arm 636 to the ram 624.

[0106] The wave spring 628 disposed between the flexible arm 636 and the ram 624 may be moveable relative to the distal end of the ram 624 between a neutral position (Figs. 20, 22) and a compressed position (Figs. 21, 23). The wave spring 628 may be configured to deflect under a load. The wave spring 628 may urge the plunger engagement component 626 relative to the distal end of the ram 624 toward the extended position. The wave spring 628 may be substantially flat in the compressed position and may be received by either or both of the ram recess 630 and the groove 634. The wave spring 628 may extend from the ram 624 in the neutral position. The plunger engagement component 626 may be generally flush with the distal end of the ram 624 when the wave spring 628 is in the compressed position and the plunger engagement component 626 is in the retracted position.

[0107] As shown in Figs. 20-23, when the trigger 619 releases the ram 624 and the ram 624 is moved relative to the housing 612 from the pre-firing position to the fired position, the plunger engagement component 626 may engage the plunger 616. The frictional force between the plunger 616 and the medicament container 614 may be greater than the initial force of the wave spring 628 acting on the plunger engagement component 626. The engagement between the plunger 616 and the plunger engagement component 626 may force the wave spring 628 to move relative to the distal endof the ram 624 from the neutral position to the compressed position when the ram 624 is moved relative to the housing 612 from the pre-firing position to the fired position. The wave spring 628 may act on the ram 624 as the wave spring 628 is moved relative to the distal end of the housing 612 toward the compressed position. The wave spring 628 may temporarily inhibit distal movement of the plunger 616 relative to the medicament container 614 and may temporarily slow the distal movement of the ram 624 relative to the medicament container 614 as the wave spring 628 is moved from the neutral position to the compressed position.

[0108] When the wave spring 628 is in the compressed position and the plunger engagement component 626 is in the retracted position, the energy source 620 may overcome the frictional force between the plunger 616 and the medicament container 614 and cause the ram 624 to urge the plunger 616 relative to the medicament container 614. The ram 624 and the plunger engagement component 626 may act as a single component acting on the plunger 616 when the plunger engagement component 626 is in the retracted position. The plunger engagement component 626 may move the plunger 616 relative to the medicament container 614 when the force of the ram 624 and the plunger engagement component 626 overcomes a frictional engagement of the plunger 616 and the medicament container 614. As shown in Fig. 20, the plunger engagement component 626 may be spaced apart from the plunger 616 when the ram 624 is in the pre-firing position. In some embodiments, the plunger engagement component 626 is in contact with the plunger 616 when the ram 624 is in the pre-firing position.

[0109] As shown in Figs. 24-27, there is a seventh exemplary embodiment of the dampener of the injector 710, hereinafter referred to as dampener 722. Dampener 722 may include a ram 724, a plunger engagement component 726 spaced apart from the ram 724 and a flex tab 728 disposed between the ram 724 and the plunger engagement component 726. The ram 724 may be a generally cylindrical member extending along the longitudinal axis LA. The ram 724 may have a proximal end and a distal end opposite the proximal end. The plunger engagement component 726 may be spaced apart from the distal end of the ram 724. The flex tab 728 extends from the distal end of the ram 724 and may engage the plunger engagement component 726, as described in more detail below.

[0110] As shown in Figs. 24-27, the distal end of the ram 724 may include two flex tabs 728 extending distally therefrom. The number of flex tabs 728 and the size of each of the flex tabs 728 may depend on the particular application of the injector 710. The flex tab 728 may be shaped and sized to achieve a desired resistance to movement of the plunger engagement component 726 relative to the ram 724. The flex tab 728 may have an inner side that extends along a plane that is substantially parallel to the longitudinal axis LAand an outer side that extends along a plane that is angled relative to the longitudinal axis LA. The flex tab 728 may be angled inward toward the distal end thereof. Forexample, a distance between the inner side and the outer side may be less at a portion that is spaced apart from the distal end of the ram 724 than a portion that is proximate the distal end of the ram 724. The flex tab 728 may include a protrusion 730 extending radially outward therefrom. The protrusion 730 may be angled so as to urge the flex tab 728 inward relative to the longitudinal axis LAin response to a force acting thereon, as described in more detail below.

[0111] As shown in Figs. 24-27, the plunger engagement component 726 may be a generally circular member having a proximal side and a distal side opposite the proximal side. The plunger engagement component 726 may have an aperture 732 extending therethrough. The aperture may be shaped and sized to allow the flex tab 728 to pass therethrough. During assembly, the protrusion 730 of the flex tab 728 may engage the aperture of the plunger engagement component 726 and force the flex tab 728 to flex inward relative to the longitudinal axis LAto pass through the aperture 732. The protrusion 730 may be shaped to prevent the plunger engagement component 726 from passing thereby once the protrusion 730 has passed through the aperture 732. The protrusion 730 may couple the plunger engagement component 726 to the ram 724.

[0112] The plunger engagement component 726 may be moveable relative to the distal end of the ram 724 between an extended position and a retracted position. The proximal side of the plunger engagement component 726 may be spaced apart from the distal end of the ram 724 in the extended position. The proximal side of the plunger engagement component 726 may be in contact with the distal end of the ram 724 in the retracted position. In some embodiments, the proximal side of the plunger engagement component 726 is closer to the ram 724 in the retracted position than the extended position. The aperture 732 may have a width that is less than a width between the outer sides of the flex tabs 728. The angled outer sides of the flex tabs 728 may inhibit the limit proximal movement of the plunger engagement component 726 relative to the ram 724.

[0113] As shown in Figs. 24-27, when the trigger 719 releases the ram 724 and the ram 724 is moved relative to the housing 712 from the pre-firing position to the fired position, the plunger engagement component 726 may engage the plunger 716. The flex tab 728 may engage the aperture 732 of the plunger engagement component 726 when the ram 724 is moved relative to the housing 712 from the pre-firing position to the fired position. The frictional force between the plunger 716 and the medicament container 714 may be greater than the initial frictional force of the outer sides of the flex tabs 728 and the aperture 732.

[0114] The engagement between the plunger 716 and the plunger engagement component 726 may force the plunger engagement component 726 to move relative to the distal end of the ram 724 from the extended position to the retracted position when the ram 724 is moved relative to the housing 712 from the pre-firing position to the fired position. The flex tabs 728 may be urged inward relativeto the longitudinal axis LAby the aperture 732 as the plunger engagement component 726 is moved relative to the distal end of the ram 724 toward the retracted position. The frictional force between the flex tabs 728 and the aperture 732 may increase as the plunger engagement component 726 is moved relative to the distal end of the ram 724 toward the retracted position. The engagement of the flex tab 728 and the plunger engagement component 726 may temporarily inhibit distal movement of the plunger 716 relative to the medicament container 714 and may temporarily slow the distal movement of the ram 724 relative to the medicament container 714 as the plunger engagement component 726 is moved from the extended position to the retracted position.

[0115] As shown in Figs. 24-27, when the plunger engagement component 726 is in the retracted position, the energy source 720 may overcome the frictional force between the plunger 716 and the medicament container 714 and cause the ram 602 to urge the plunger 716 distally relative to the medicament container 714. The ram 724 and the plunger engagement component 726 may act as a single component acting on the plunger 716 when the plunger engagement component 726 is in the retracted position. The plunger engagement component 726 may move the plunger 716 relative to the medicament container 714 when the frictional engagement of the flex tab 728 and the plunger engagement component 726 overcomes a frictional engagement of the plunger 716 and the medicament container 714. As shown in Fig. 24, the plunger engagement component 726 may be spaced apart from the plunger 716 when the ram 724 is in the pre-firing position. In some embodiments, the plunger engagement component 726 is in contact with the plunger 716 when the ram 724 is in the pre-firing position. The flex tab 728 may extend through the aperture 732 when the ram 724 is in the fired position. As shown in Fig. 25, the flex tab 728 may be disposed at least partially within the plunger 716 when the ram 724 is in the fired position.

[0116] As shown in Figs. 28-31, there is shown an eighth exemplary embodiment of the dampener of the injector 810, hereinafter referred to as dampener 822. Dampener 822 may include a ram 824 and a deformable tip 826 disposed thereon. The ram 824 may be a generally cylindrical member extending along the longitudinal axis LA. The ram 824 may have a proximal end and a distal end opposite the proximal end.

[0117] As shown in Figs. 28-31, the deformable tip 826 may be disposed on the distal end of the ram 824. The deformable tip 826 may include a post 828 extending from the distal end of the ram 824 and at least one lobe 830 extending radially out from the post 828. The deformable tip 826 may be fixed relative to the ram 824. The post 828 may be a generally cylindrical member. In some embodiments, the post 828 has a square, triangle or other polygonal cross-section. The lobe 830 may extend from the post 828 and may have a curved outer edge 832. The outer edge 832 may have a curvature substantially similar to that of a circumference of the ram 824. In some embodiments, theouter edge 832 may have a curvature that is smaller than the circumference of the ram 824. The deformable tip 826 may include a plurality of lobes 830. The deformable tip 826 may have four lobes 830. Each lobe 830 may cover approximately 60° of the curvature of the deformable tip 826. The number of lobes 830 and the size of each lobe 830 may depend on the particular application of the injector 810. As the number of lobes 830 increases, the degree of coverage of each lobe 830 may decrease. The lobe 830 may have a radius on the proximal surface of the outer edge 832 to prevent catching the plunger 816 when the ram 824 is moved proximally relative to the plunger 816.

[0118] The deformable tip 826 may be moveable relative to the distal end of the ram 824 between a neutral position (Figs. 28, 30) and a compressed position (Figs. 29, 31). The deformable tip 826 may be configured to deform under a load. The lobe 830 may extend distally and outwardly relative to the post in the neutral position. The lobe 830 may extend proximally and outwardly relative to the post in the neutral position.

[0119] As shown in Figs. 28-31, when the trigger 819 releases the ram 824 and the ram 824 is moved relative to the housing 812 from the pre-firing position to the fired position, the deformable tip 826 may engage the plunger 816. The frictional force between the plunger 816 and the medicament container 814 may be greater than the lobe’s 830 force of resistance to deflection. The engagement between the plunger 816 and the deformable tip 826 may force the deformable tip 826 to move relative to the distal end of the ram 824 from the neutral position to the compressed position when the ram 824 is moved relative to the housing 812 from the pre-firing position to the fired position. The deformable tip 826 may act on the ram 824 as the deformable tip 826 is moved toward the compressed position. The deformable tip 826 may temporarily inhibit distal movement of the plunger 816 relative to the medicament container 814 and may temporarily slow the distal movement of the ram 824 relative to the medicament container 814 as the deformable tip 826 is moved from the neutral position to the compressed position.

[0120] When the deformable tip 826 is in the compressed position, the energy source 820 may overcome the frictional force between the plunger 816 and the medicament container 814 and cause the ram 824 to urge the plunger 816 distally relative to the medicament container 814. The ram 824 and the deformable tip 826 may act as a single component acting on the plunger 816 when the deformable tip 826 is in the compressed position. The lobe 830 may be shaped to flushly engage the plunger 816 when the deformable tip 826 is in the compressed position. The deformable tip 826 may move the plunger 816 relative to the medicament container 814 when the force of the ram 824 and the deformable tip 826 overcomes a frictional engagement of the plunger 816 and the medicament container 814. As shown in Fig. 28, the deformable tip 826 may be spaced apart from the plunger816 when the ram 824 is in the pre-firing position. In some embodiments, the deformable tip 826 is in contact with the plunger 816 when the ram 824 is in the pre-firing position.

[0121] As shown in Figs. 32-35, there is a ninth exemplary embodiment of the dampener of the injector 910, hereinafter referred to as dampener 922. Dampener 922 may include a ram 924 and a deformable tip 926 disposed thereon. The ram 924 may be a generally cylindrical member extending along the longitudinal axis LA. The ram 924 may have a proximal end and a distal end opposite the proximal end.

[0122] As shown in Figs. 32-35, the deformable tip 926 may be disposed on the distal end of the ram 924. The deformable tip 926 may be a generally circular member fixed on the distal end of the ram 924. The deformable tip 926 may have a circumference that is smaller than a circumference of the ram 924. In some embodiments, the deformable tip 926 has a circumference that is substantially similar to the circumference of the ram 924. The deformable tip 926 may include at least one spiral finger 928 extending distally therefrom. The spiral finger 928 may extend around approximately 90° of the circumference of the deformable tip 926. The spiral finger 928 may be anchored to a base 930 that extends around approximately 30° of the circumference of the deformable tip 926. The number of spiral fingers 928 and the length of each spiral finger 928 may vary depending on the specific application of the injector 910. The spiral finger 928 may protrude from the deformable tip 926 at an angle when no load is applied and may be flush with the deformable tip 926 when a load is applied. The deformable tip 926 may include three spiral fingers 928. The deformable tip 926 may include a plurality of spiral fingers 928. In some embodiments, there is one spiral finger 928.

[0123] The deformable tip 926 may be moveable relative to the distal end of the ram 924 between a neutral position (Figs. 32, 34) and a compressed position (Figs. 33, 35). The deformable tip 926 may be configured to deform under a load. When the trigger 919 releases the ram 924 and the ram 924 is moved relative to the housing 912 from the pre-firing position to the fired position, the deformable tip 926 may engage the plunger 916. The frictional force between the plunger 916 and the medicament container 914 may be greater than the spiral finger’s 928 initial force of resistance to deflection. The engagement between the plunger 916 and the deformable tip 804 may force the deformable tip 926 to move relative to the distal end of the ram 924 from the neutral position to the compressed position when the ram 924 is moved relative to the housing 912 from the pre-firing position to the fired position. The deformable tip 926 may act on the ram 924 as the deformable tip 926 is moved relative to the distal end of the housing 912 toward the compressed position. The deformable tip 926 may temporarily inhibit distal movement of the plunger 916 relative to the medicament container 914 and may temporarily slow the distal movement of the ram 924 relative tothe medicament container 914 as the deformable tip 926 is moved from the neutral position to the compressed position.

[0124] When the deformable tip 926 is in the compressed position, the energy source 920 may overcome the frictional force between the plunger 916 and the medicament container 914 and cause the ram 924 to urge the plunger 916 distally relative to the medicament container 914. The ram 924 and the deformable tip 926 may act as a single component acting on the plunger 916 when the deformable tip 926 is in the compressed position. The spiral finger 928 may be configured to flushly engage the plunger 916 when the deformable tip 926 is in the compressed position. The deformable tip 926 may move the plunger 916 relative to the medicament container 914 when the force of the ram 924 and the deformable tip 926 overcomes a frictional engagement of the plunger 916 and the medicament container 914. As shown in Fig. 32, the deformable tip 926 may be spaced apart from the plunger 916 when the ram 924 is in the pre-firing position. In some embodiments, the deformable tip 926 is in contact with the plunger 916 when the ram 924 is in the pre-firing position.

[0125] The term “about” or “approximately” is used herein to provide literal support for the exact number that it precedes, as well as a number that is near to or approximately the number that the term precedes. In determining whether a number is near to or approximately a specifically recited number, the near or approximating unrecited number may be a number, which, in the context in which it is presented, provides the substantial equivalent of the specifically recited number. It should be appreciated that all numerical values and ranges disclosed herein are approximate values and ranges, whether “about” is used in conjunction therewith. It should also be appreciated that the term “about,” as used herein, in conjunction with a numeral refers to a value that may be ±0.01% (inclusive) of that numeral, ±0.1% (inclusive) of that numeral, ±0.5% (inclusive) of that numeral, ±1% (inclusive) of that numeral, ±2% (inclusive) of that numeral, ±3% (inclusive) of that numeral, ±5% (inclusive) of that numeral, ±10% (inclusive) of that numeral, or ±15% (inclusive) of that numeral. It should further be appreciated that when a numerical range is disclosed herein, any numerical value falling within the range is also specifically disclosed.

[0126] It will be appreciated by those skilled in the art that changes could be made to the exemplary embodiments shown and described above without departing from the broad inventive concepts thereof. It is to be understood that the embodiments and claims disclosed herein are not limited in their application to the details of construction and arrangement of the components set forth in the description and illustrated in the drawings. Rather, the description and the drawings provide examples of the embodiments envisioned. The embodiments and claims disclosed herein are further capable of other embodiments and of being practiced and carried out in various ways.

[0127] Specific features of the exemplary embodiments may or may not be part of the claimed invention and various features of the disclosed embodiments may be combined. Unless specifically set forth herein, the terms “a,” “an” and “the” are not limited to one element but instead should be read as meaning “at least one.” Finally, unless specifically set forth herein, a disclosed or claimed method should not be limited to the performance of its steps in the order written, and one skilled in the art can readily appreciate that the steps may be performed in any practical order.

Claims

CLAIMSWhat is claimed is:

1. An inj ector having: a housing having a proximal end and a distal end extending along a longitudinal axis; a medicament container disposed at least partially within the housing; a plunger disposed within the medicament container; a ram configured to move the plunger relative to the medicament container, the ram disposed within the housing and moveable relative to the housing between a pre-firing position and a fired position; an energy source configured to move the ram from the pre-firing position to the fired position; and a dampener disposed within the housing and configured to engage the ram to reduce an initial force exerted by the ram on the plunger when the ram is moved from the pre-firing position to the fired position.

2. The injector of claim 1 further comprising: a latch disposed within the housing having a spine defined along a portion thereof, the spine having a notch protruding therefrom, a slot configured to receive the spine defined along a portion of the ram, the slot having a protrusion protruding therefrom, wherein the notch temporarily engages the protrusion when the ram is moved from the prefiring position to the fired position.

3. The injector of claim 2, wherein the notch engaging the protrusion temporarily inhibits distal movement of the ram relative to the medicament container.

4. The injector of claim 3, wherein a force of the energy source acting on the ram overcomes the engagement of the notch and protrusion to move the ram from the pre-firing position to the fired position.

5. The injector of claim 4, wherein the ram is spaced apart from the protrusion in the pre-firing position.

6. The injector of claim 5, wherein the ram is in contact with the plunger when the force of the energy source overcomes the engagement of the notch and protrusion.

7. The injector of claim 6, wherein the ram moves the plunger relative to the medicament container when the force of the ram overcomes a frictional engagement of the plunger and the medicament container.

8. The injector of claim 2, wherein engagement of the notch and the slot prevents rotation of the ram relative to the latch when the ram is moved from the pre-firing position to the fired position.

9. The injector of claim 1 further comprising: a latch disposed within the housing, the latch having a latch body configured to receive a proximal end of the ram therein, wherein at least a portion of the latch body is tapered inward toward a proximal end, and wherein the proximal end of the ram is engaged by the tapered portion of the latch body.

10. The injector of claim 9, wherein engagement between the ram and the latch body temporarily inhibits distal movement of the ram relative to the medicament container.

11. The injector of claim 10, wherein a force generated by the energy source overcomes the engagement of the ram and the latch body to move the ram from the pre-firing position to the fired position.

12. The injector of claim 11, wherein the ram is spaced apart from the plunger in the pre-firing position.

13. The injector of claim 12, wherein the ram is in contact with the plunger when the energy source overcomes the engagement of the ram and the latch body.

14. The injector of claim 13, wherein the ram moves the plunger relative to the medicament container when the force of the ram overcomes a frictional engagement of the plunger and the medicament container.

15. The injector of claim 9, wherein the proximal end of the ram is tapered outward toward the proximal end.

16. The injector of claim 1, wherein the distal end of the ram is tapered in toward the distal end.

17. The injector of claim 16 further comprising: a ram cap disposed at least partially around the distal end of the ram, the ram cap having an interior taper that is generally the same as the taper of the distal end of the ram.

18. The injector of claim 17, wherein movement of the ram from the pre-firing position to the fired position causes the distal end of the ram to engage the ram cap, and wherein a frictional engagement of the ram and the ram cap temporarily inhibits distal movement of the ram relative to the medicament container.

19. The injector of claim 18, wherein the ram cap moves the plunger relative to the medicament container when the frictional engagement of the ram and the ram cap overcomes a frictional engagement of the plunger and the medicament container.

20. The injector of claim 17, wherein the ram is spaced apart from the ram cap in the pre-firing position.21 . The injector of claim 17, wherein the ram cap has at least one slit extending along the longitudinal axis from a proximal end thereof, and wherein a frictional engagement of the ram and ram cap causes the slit to increase a circumference of the ram cap.

22. The injector of claim 1, wherein the dampener comprises: a dampener body extending from the distal end of the ram; a plunger engagement component moveable relative to the dampener body between an extended position and a compressed position; and a dampener spring configured to urge the plunger engagement component toward the extended position.

23. The injector of claim 22, wherein the plunger engagement component engages the plunger and is moved from the extended position to the compressed position by the plunger when the ram is moved from the pre-firing position to the fired position.

24. The injector of claim 23, wherein the dampener spring temporarily inhibits distal movement of the ram relative to the medicament container as the plunger engagement component is moved from the extended position to the compressed position.

25. The injector of claim 24, wherein the plunger engagement component moves the plunger relative to the medicament container when the force of the ram and the plunger engagement component overcomes a frictional engagement of the plunger and the medicament container.

26. The injector of claim 1, wherein the dampener comprises: a disc spring disposed on the distal end of the ram, the disc spring moveable between a neutral position and a compressed position.

27. The injector of claim 26, wherein the disc spring engages the plunger and is moved from the neutral position to the compressed position by the plunger when the ram is moved from the prefiring position to the fired position.

28. The injector of claim 27, wherein the disc spring temporarily inhibits distal movement of the ram relative to the medicament container as the disc spring is moved from the neutral position to the compressed position.

29. The injector of claim 28, wherein the disc spring moves the plunger relative to the medicament container when the force of the ram and the disc spring overcomes a frictional engagement of the plunger and the medicament container.

30. The injector of claim 26, wherein the disc spring is fixed relative to the ram.

31. The injector of claim 1, wherein the dampener comprises: a plunger engagement component spaced apart from the distal end of the ram; and a wave spring disposed between the plunger engagement component and the distal end of the ram, the wave spring moveable between a neutral position and a compressed position.

32. The injector of claim 31, wherein the plunger engagement component engages the plunger and the wave spring is moved from the neutral position to the compressed position when the ram is moved from the pre-firing position to the fired position.

33. The injector of claim 32, wherein the wave spring temporarily inhibits distal movement of the ram relative to the medicament container as the wave spring is moved from the neutral position to the compressed position.

34. The injector of claim 33, wherein the plunger engagement component moves the plunger relative to the medicament container when the force of the ram and the plunger engagement component overcomes a frictional engagement of the plunger and the medicament container.

35. The injector of claim 31, wherein the plunger engagement component is generally flush with the distal end of the ram when the wave spring is in the compressed position.

36. The injector of claim 1, wherein the dampener comprises: a plunger engagement component spaced apart from the distal end of the ram, the plunger engagement component having an aperture extending therefrom; and a flex tab angled inward to the distal end and extending from the distal end of the ram, the flex tab configured to pass through the aperture of the plunger engagement component.

37. The injector of claim 36, wherein the flex tab engages the aperture of the plunger engagement component when the ram is moved from the pre-firing position to the fired position.

38. The injector of claim 37, wherein the engagement of the flex tab and the plunger engagement component temporarily inhibits distal movement of the ram relative to the medicament container.

39. The injector of claim 38, wherein the plunger engagement component moves the plunger relative to the medicament container when a frictional engagement of the flex tab and the plunger engagement component overcomes a frictional engagement of the plunger and the medicament container.

40. The injector of claim 37, wherein the flex tab extends through the aperture when the ram is in the fired position.

41. The injector of claim 37, wherein the flex tab is disposed at least partially within the plunger when the ram is in the fired position.

42. The injector of claim 1, wherein the dampener comprises: a deformable tip disposed on the distal end of the ram, the deformable tip moveable between a neutral position and a compressed position.

43. The injector of claim 42, wherein the deformable tip engages the plunger and is moved from the neutral position to the compressed position by the plunger when the ram is moved from the prefiring position to the fired position.

44. The injector of claim 43, wherein the deformable tip temporarily inhibits distal movement of the ram relative to the medicament container as the deformable tip is moved from the neutral position to the compressed position.

45. The injector of claim 44, wherein the deformable tip moves the plunger relative to the medicament container when the force of the ram and deformable tip overcomes a frictional engagement of the plunger and the medicament container.

46. The injector of claim 42, wherein the deformable tip is fixed relative to the ram.

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