The invention discloses a combined loading balancing switching self-optimization method in a mobile communication system. The combined loading balancing switching self-optimization method in the mobile communication system comprises the following steps: according to the switching starting process of LTE (long term evolution), the ordered set theta of eNB calculation of LTE is obtained; in the optimization period T1, the switching failure rate and the ping-pong switching rate of each eNB to a notch are recorded, and the self-optimization algorithm of external circulation is executed, thus the switching performance meets the requirement; when the switching performance of the system meets the requirement, in the optimization period T2, the admitted rejection rate is recorded by each eNB, the total switching failure rate is recorded, and the switching parameter combination in the ordered set theta is regulated; and each eNB determines whether the total switching failure rate is minimum, and the switching parameter combination of the next optimization period T2 is determined. According to the invention, the switching performance of the system is ensured; the switching parameters can be regulated through self optimization according to the variation of target cell loading, thus the total switching failure rate becomes minimal, and meanwhile, the function of loading balancing can be finished partially.