A novel 2-benzyloxy-benzoic acid ester compound that regulates the activity of estrogen-related receptors and its medical application

A compound, estrogen technology, applied in organic chemistry, drug combination, active ingredient of amide, etc.
CN106543044BInactive Publication Date: 2018-05-22QILU UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
QILU UNIV OF TECH
Publication Date
2018-05-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses a compound of novel 2-benzyloxy-benzoic acid esters with formula I for regulating the activity of estrogen-related receptors, its pharmaceutically acceptable salt and its application. The compound and its pharmaceutically acceptable salt can be used for the preparation of estrogen-related receptor ERR-alpha (Estrogen-related receptor alpha, ERR-alpha or ERRα) activity for the prevention and treatment of breast cancer, prostate cancer, gastric cancer, colon cancer Cancer, ovarian cancer, cervical cancer and other malignant tumors.
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Description

technical field

[0001] The present invention relates to a novel 2-benzyloxy-benzoic acid ester compound and its pharmaceutically acceptable salts as a method for regulating estrogen-related receptor alpha (ERR-alpha or ERRα). Agents and their drug combinations and their use in the preparation of drugs for the prevention and / or treatment of tumors such as breast cancer, prostate cancer, gastric cancer, colon cancer, ovarian cancer, cervical cancer or endometrial cancer. Background technique

[0002] ERRα was cloned and identified by Giguere et al. in 1988. As an orphan nuclear receptor (Orphan nuclear receptor), the endogenous ligand of ERRα has not been discovered. ERRα is widely expressed in the body and can be detected from myocardium, digestive tract, brain, skeletal muscle, brown fat, breast cancer, ovarian cancer and other malignant tumors. ERRα has high homology with estrogen receptor α (ERα): DNA binding domain (DNA binding domain, DBD) amino acid similarity is 68%,...

Claims

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