Constructs targeting NY-ESO-1 peptide/MHC complexes and uses thereof

Abstract

The present application provides constructs comprising an antibody moiety that specifically binds to a complex comprising an NY-ESO-1 peptide and an MHC class I protein. Also provided are methods of making and using these constructs.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Application No. 62 / 142,958, filed April 3, 2015, and U.S. Provisional Application No. 62 / 184,185, filed June 24, 2015, all of which are hereby incorporated by reference in their entirety . technical field [0003] The present invention relates to antibody constructs that specifically bind MHC molecules complexed with NY-ESO-1 peptides, and uses thereof, including treatment and diagnosis of diseases. [0004] Submit a sequence listing as an ASCII text file [0005] The following, filed as an ASCII text file, is hereby incorporated by reference in its entirety: Sequence Listing in Computer Readable Form (CRF) (File Name: 7500420001440SEQLIST.txt, Date of Record: June 24, 2016, Size: 65KB) . Background technique [0006] Cell surface proteins constitute only a small fraction of cellular proteins and these proteins are often not tumor specific. Because they cannot ea...

AI Technical Summary

Problems solved by technology

Due to the high sequence homology between LAGE-1 and NY-ESO-1, serologic assays often do not differentiate in tumors expressing the two antigens (Nicholaou T et al, supra)

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