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Constructs targeting NY-ESO-1 peptide/MHC complexes and uses thereof

A technology of NY-ESO-1 and constructs, which is applied in the direction of targeting specific cell fusion, polypeptides containing positioning/targeting motifs, and medical preparations containing active ingredients, etc.

Inactive Publication Date: 2018-04-17
EUREKA THERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high sequence homology between LAGE-1 and NY-ESO-1, serologic assays often do not differentiate in tumors expressing the two antigens (Nicholaou T et al, supra)

Method used

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  • Constructs targeting NY-ESO-1 peptide/MHC complexes and uses thereof
  • Constructs targeting NY-ESO-1 peptide/MHC complexes and uses thereof
  • Constructs targeting NY-ESO-1 peptide/MHC complexes and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0557] Embodiment 1. In some embodiments, there is provided an isolated anti-EMC construct comprising a complex (NY-ESO- 1 / MHC class I complex, or the antibody portion of the EMC).

Embodiment approach 2

[0558] Embodiment 2. In some other embodiments of embodiment 1, the NY-ESO-1 / MHC class I complex is present on the surface of the cell.

Embodiment approach 3

[0559] Embodiment 3. In some other embodiments of embodiment 1, the NY-ESO-1 / MHC class I complex is present on the surface of the cancer cell.

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PUM

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Abstract

The present application provides constructs comprising an antibody moiety that specifically binds to a complex comprising an NY-ESO-1 peptide and an MHC class I protein. Also provided are methods of making and using these constructs.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Application No. 62 / 142,958, filed April 3, 2015, and U.S. Provisional Application No. 62 / 184,185, filed June 24, 2015, all of which are hereby incorporated by reference in their entirety . technical field [0003] The present invention relates to antibody constructs that specifically bind MHC molecules complexed with NY-ESO-1 peptides, and uses thereof, including treatment and diagnosis of diseases. [0004] Submit a sequence listing as an ASCII text file [0005] The following, filed as an ASCII text file, is hereby incorporated by reference in its entirety: Sequence Listing in Computer Readable Form (CRF) (File Name: 7500420001440SEQLIST.txt, Date of Record: June 24, 2016, Size: 65KB) . Background technique [0006] Cell surface proteins constitute only a small fraction of cellular proteins and these proteins are often not tumor specific. Because they cannot ea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/705A61K39/395G01N33/574
CPCG01N33/57492G01N2333/70539C07K16/2809C07K16/2833C07K16/3069C07K14/00C07K2317/21C07K2317/31C07K2317/32C07K2317/33C07K2317/34C07K2317/56C07K2317/622C07K2317/73C07K2317/92C07K2319/03C07K14/4748A61P35/00A61K2039/5158A61K2039/5156C07K14/7051A61K39/0011C12N5/0636A61K2039/505C07K2317/565C07K14/70521C07K16/468C07K2317/732C07K2317/734C07K2317/76C07K2319/02C07K2319/30C07K2319/33
Inventor 刘诚刘宏许奕阳向京宜
Owner EUREKA THERAPEUTICS INC
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