Composition, granules and preparation method for preventing and treating gout in goslings

Abstract

The present invention relates to a composition, granules and preparation method for preventing and treating gout in goslings, the composition comprising the following raw materials in parts by weight: 55-75 parts of Bletilla striata, 70-90 parts of Cinnamon bark, 50-70 parts of Eucommia bark, 80-100 parts of Cuscuta australis, 90-110 parts of White Peony Root, 80-100 parts of Astragalus, 40-60 parts of Radix Aconiti Carmichaelii, 60-80 parts of Angelica sinensis, 60-80 parts of Acorus calamus, 90-110 parts of Litchi Seed, 50-70 parts of Notopterygium wilfordii, 55-75 parts of Rhubarb, and 90-110 parts of Chicory Root. The present invention not only takes into account the characteristics that young animals cannot tolerate bitter cold and cannot be attacked too much, but also takes into account the characteristics that goslings have an acute onset of gout, can effectively detoxify and promote the rapid disappearance of clinical manifestations of gout in goslings.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese veterinary medicines, and particularly relates to a composition and granules for preventing and treating gout in goslings, and a preparation method thereof. Background Art

[0002] Studies have shown that gout in goslings is an acute infectious disease caused by a new type of goose astrovirus, characterized by the presence of large amounts of uric acid deposits in the pericardium, kidneys, liver and other internal organs and joints of goslings. It can spread widely in a short period of time. It is characterized by mainly affecting young geese, with an acute onset and severe condition, but has nothing to do with goose breeds and feeding methods. It occurs in breeding geese of different breeds and feeding methods.

[0003] There are currently several ways to treat gout in goslings caused by the new goose astrovirus: 1) Antibody vaccination therapy, which has the following problems: astrovirus culture is relatively difficult, and the virus replication titer is not high, resulting in uneven antibody titers, which affects the prevention and treatment of gout in goslings; 2) Interferon administration therapy: Since interferon is a universal therapeutic preparation for viral diseases, it has poor targeting and the treatment effect is not ideal; 3) Symptomatic treatment with kidney-protecting diuretic drugs: It can reduce complications or secondary infections of other diseases to a certain extent and relieve disease symptoms, but it is only a temporary solution and cannot fundamentally eliminate the cause of gout in goslings. The drug effect takes a long time to take effect, and the treatment effect is average for gout in goslings with rapid onset. Therefore, there is currently no effective prevention and treatment plan for gout in goslings caused by the new goose astrovirus. Summary of the invention

[0004] The purpose of the present invention is to overcome the defects in the prior art and provide a composition, granules and preparation method for preventing and treating gout in goslings, which can effectively prevent and treat gout.

[0005] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0006] Technical solution 1:

[0007] A composition for preventing and treating gout in goslings, comprising the following raw materials in parts by weight:

[0008] Bletilla striata 55-75 copies;

[0009] 70-90 parts cinnamon;

[0010] Eucommia ulmoides 50-70 parts;

[0011] 80-100 parts of paper mulberry seeds;

[0012] 90-110 parts of white peony root;

[0013] 80-100 parts of Astragalus;

[0014] 40-60 portions of processed Chuanwu;

[0015] 60-80 parts of Chinese Angelica;

[0016] 60-80 parts of Acorus calamus;

[0017] 90-110 parts of litchi kernels;

[0018] 50-70 parts of Notopterygium wilfordii;

[0019] 55-75 parts rhubarb;

[0020] Chicory root 90-110 parts.

[0021] As a preferred technical solution, a composition for preventing and treating gout in goslings also includes 50-80 parts of bromelain.

[0022] As a preferred technical solution, a composition for preventing and treating gout in goslings comprises the following raw materials in parts by weight:

[0023] 65 samples of Bletilla striata from Central Asia;

[0024] 80 parts cinnamon;

[0025] Eucommia ulmoides 60 parts;

[0026] 90 parts of Paper mulberry seeds;

[0027] 100 parts of white peony root;

[0028] Astragalus 90 parts;

[0029] 50 portions of processed Chuanwu;

[0030] Angelica sinensis 70 parts;

[0031] Acorus calamus 70 parts;

[0032] 100 parts of litchi kernels;

[0033] 60 portions of Notopterygium wilfordii;

[0034] rhubarb 65 parts;

[0035] 100 servings of chicory root.

[0036] Technical solution 2:

[0037] A traditional Chinese medicine preparation prepared from the composition for preventing and treating gout in goslings, wherein the traditional Chinese medicine preparation is an oral preparation, and the oral preparation comprises one or more of decoctions, granules and syrups.

[0038] Technical solution three:

[0039] A traditional Chinese medicine granule prepared from the composition for preventing and treating gout in goslings.

[0040] Technical solution 4:

[0041] A method for preparing the Chinese medicine granules comprises the following steps:

[0042] Step 1: Oil Extraction

[0043] After weighing each raw material by weight, cinnamon bark, calamus calamus, white peony root and rhubarb are crushed and passed through a No. 2 sieve to make coarse powder, which is then soaked in water and decocted to collect volatile oil, decoction A and medicinal residues for later use.

[0044] Step 2: Decoction

[0045] Add Bletilla striata, Eucommia bark, Cuscuta australis, Astragalus, Aconiti Radix Angelicae Sinensis, Litchi Seed, Notopterygium wilfordii, and Chicory Root to the residue obtained in step 1, add water and boil for 2-3 times, collect decoction B, combine it with decoction A in step 1, and concentrate it to obtain a concentrated clear paste;

[0046] Step 3: Granulation

[0047] Add bromelain and dextrin to the concentrated clear paste prepared in step 2, mix well, and then wet-extrude and granulate. After the wet granules are dried, granules are obtained.

[0048] Step 4: Spray back the volatile oil

[0049] Spray the volatile oil collected in step 1 onto the granules obtained in step 3 while stirring. After the spraying is completed, place the granules in a sealed container for 24 hours and quickly divide the granules into small packages.

[0050] As a preferred technical solution, during decoction in step 1, the mass ratio of material to liquid is 1:4-6;

[0051] The decoction temperature of step 1 is 100° C. and the decoction time is 40-60 min.

[0052] As a preferred technical solution, in step 2, each time of decoction, the volume ratio of the material to the liquid is 1:8-10; the temperature of each decoction is 100°C, and the time of each decoction is 60-90 minutes;

[0053] In step 2, the concentration is carried out at a temperature of 70-80° C. and a vacuum degree of -0.05 MPa to a density of 1.2-1.3.

[0054] As a preferred technical solution, in step 3, the drying is carried out by fluidized bed drying, and the drying temperature is less than or equal to 45°C.

[0055] In the present invention,

[0056] Bletilla striata: Strengthens yang and produces essence, nourishes the heart and produces blood. Replenishes kidney yang, strengthens liver and kidney function, enhances metabolism, and reduces liver and kidney damage.

[0057] Cinnamon: pungent, sweet and hot in nature. It enters the kidney, spleen and bladder meridians. It replenishes the primordial yang, warms the spleen and stomach, and dredges the blood vessels. From the clinical point of view, gout is caused by the accumulation of a large amount of uric acid salts, which is due to the lack of yang energy in the whole body, the body's metabolism is reduced, and uric acid salts are slowly deposited, leading to the onset of the disease. Therefore, it belongs to the cold syndrome in dialectics, and cold also leads to blood vessel occlusion. Therefore, cinnamon replenishes the primordial yang, warms the blood vessels, enhances the body's metabolic capacity, and opens up the metabolic pathway.

[0058] Eucommia: sweet, slightly spicy, warm. Enters the liver and kidney meridians. Nourishes the liver and kidneys, strengthens the tendons and bones, and can effectively improve problems such as soreness of the waist and knees, and poor flexion and extension of joints caused by kidney deficiency.

[0059] Cuscuta australis: cold in nature, sweet in taste. Enters the liver and kidney meridians. Nourishes the kidneys and liver, improves eyesight, and promotes urination. Together with Eucommia ulmoides, it warms and nourishes the liver and kidneys, increases liver and kidney cell metabolism, promotes liver cell regeneration, and repairs liver and kidney damage.

[0060] White Peony Root: slightly cold in nature, bitter and sour in taste. It enters the liver and spleen meridians; soothes the liver and relieves pain, nourishes blood and regulates menstruation, and restrains yin and stops sweating.

[0061] Astragalus: replenishes qi and strengthens the exterior, promotes diuresis and reduces swelling. It can treat qi and blood and improve the body's barrier function.

[0062] Angelica: sweet, pungent, warm, nourishes blood; activates blood circulation; regulates menstruation and relieves pain; moisturizes and lubricates the intestines. Angelica is sweet and heavy, so it can specifically nourish blood. Its qi is light and pungent, so it can also promote blood circulation. It can nourish and move while moving, and nourish while moving. It is an important medicine for blood. Therefore, it can nourish blood, activate blood circulation, and can both dredge menstruation and activate collaterals. Therefore, it can help the main medicine to enhance the body's metabolism.

[0063] Lychee kernel: warm in nature, sweet and slightly bitter. It can promote qi circulation, dissipate stagnation, dispel cold and relieve pain. When qi circulates, blood circulates, qi can produce blood, and blood can nourish qi. Together with astragalus and angelica, it can increase the total blood volume and enhance the body's metabolism.

[0064] Processed Chuanwu: pungent, bitter, hot; enters the heart, liver, kidney, and spleen meridians. Expels wind and dampness, warms the meridians and relieves pain. Can be used for wind-cold-dampness arthralgia, joint pain, so it can relieve joint swelling and pain caused by gout, paralysis, etc.

[0065] Qianghuo: pungent, bitter, warm in nature. Enters the bladder and kidney meridians. Dispels superficial cold, dispels rheumatism, benefits joints, and relieves pain. Together with Chuanwu, it can relieve clinical symptoms and enhance the effect of dispelling wind and relieving pain.

[0066] Chicory root: slight smell, light taste. It can clear the liver and gallbladder, strengthen the stomach and help digestion, and promote diuresis and reduce swelling. It is mild in nature and good at penetrating, which is beneficial for excreting uric acid deposited in the body.

[0067] Rhubarb: bitter, cold. Meridians: stomach meridian; large intestine meridian; liver meridian; spleen meridian. Clears away dampness and heat, purges fire and detoxifies. It can remove dampness from the body through the triple energizer. This recipe also contains herbs that neutralize the warm properties of Bletilla striata and cinnamon bark, preventing the accumulation of heat in the body and imbalance of yin and yang.

[0068] Acorus calamus: warm in nature, pungent and bitter in taste. It enters the heart meridian and stomach meridian. It can open the mind and dissipate phlegm, wake up the mind and improve intelligence, and remove dampness and stimulate the appetite. Its volatile oil has a strong antiviral effect. Therefore, in this prescription, it can not only play an antiviral role, but also remove dampness and stimulate the appetite, increase the body's food intake, and promote recovery from illness.

[0069] Compared with the prior art, the present invention has the following beneficial effects:

[0070] The present invention uses Bletilla striata, Cinnamon bark, Eucommia bark, and Cuscuta australis as the main medicines, warms and nourishes the liver and kidneys, enhances liver and kidney functions, reduces liver and kidney damage, and strengthens material metabolism; solves liver and kidney metabolic disorders caused by liver and kidney deficiency and damage caused by the use of antibiotics and other opening drugs and excessive growth in goslings, and reduces the incidence of the disease; the present invention uses white peony root, astragalus, angelica, and litchi kernel as the assistants, replenishes qi and nourishes blood, promotes qi circulation, increases blood flow metabolism, opens up metabolic pathways, strengthens the function of the main medicine, and promotes material metabolism in the body. The present invention uses processed Chuanwu, Notopterygium incisum, chicory root, rhubarb, and Acorus calamus as the assistants, warms the meridians and relieves pain, removes dampness and dredges the meridians, detoxifies and removes toxins, promotes uric acid metabolism, and removes toxins. Among them, rhubarb is bitter and cold, which can assist in treating too many warm and hot drugs, which accumulate in the body and cause imbalance of yin and yang in the body.

[0071] The volatile oils in cinnamon bark, calamus calamus, white peony root and rhubarb have antiviral, anti-inflammatory and analgesic effects. The present invention improves the process of granule preparation. In the process of decocting raw materials, the volatile oils in cinnamon bark, calamus calamus, white peony root and rhubarb are first collected and then sprayed back into the granules, thereby improving the detoxification and detoxification effects of the preparation and the speed of action of the drug effect, and has a better effect on the characteristics of rapid onset of gout in goslings.

[0072] The invention also adds bromelain into the preparation, and bromelain can promote the decomposition, digestion and absorption of nutrients, eliminate inflammation and improve the clinical symptoms of gout in goslings.

[0073] The present invention takes strengthening the body and detoxifying as the general principle of drug compatibility, uses various drugs in combination, adds bromelain at the same time, and cooperates with the improvement of the process of volatile oil collection and back-spraying, so as to promote the rapid exertion of drug efficacy, and prepare a drug preparation that can effectively prevent and treat gout disease in goslings caused by a new goose astrovirus. The drug preparation not only takes into account the characteristics that young animals cannot tolerate bitter cold and cannot be attacked too much, but also takes into account the characteristics that goslings have an acute onset of gout, can effectively detoxify and promote the rapid disappearance of clinical manifestations. DETAILED DESCRIPTION

[0074] The present invention is further described in detail below with reference to the embodiments.

[0075] Embodiment 1:

[0076] A Chinese medicinal granule for preventing and treating gout in goslings, comprising the following raw materials in parts by weight:

[0077] 65 samples of Bletilla striata from Central Asia;

[0078] 80 parts cinnamon;

[0079] Eucommia ulmoides 60 parts;

[0080] 90 parts of Paper mulberry seeds;

[0081] 100 parts of white peony root;

[0082] Astragalus 90 parts;

[0083] 50 portions of processed Chuanwu;

[0084] Angelica sinensis 70 parts;

[0085] Acorus calamus 70 parts;

[0086] 100 parts of litchi kernels;

[0087] 60 portions of Notopterygium wilfordii;

[0088] rhubarb 65 parts;

[0089] 100 parts chicory root;

[0090] Bromelain 65 parts.

[0091] The preparation method thereof comprises the following steps:

[0092] Step 1: Oil Extraction

[0093] After weighing each raw material by weight, cinnamon bark, calamus calamus, white peony root and rhubarb are crushed and passed through a No. 2 sieve to make coarse powder, and then soaked in water at a material-liquid mass ratio of 1:6, decocted at 100°C for 60 minutes, and the volatile oil, decoction A and medicinal residues are collected for later use.

[0094] Step 2: Decoction

[0095] Add Bletilla striata, Eucommia bark, Cuscuta australis, Astragalus, Aconiti Radix Angelicae Sinensis, Litchi Seed, Notopterygium wilfordii, and Chicory Root to the residue obtained in step 1, then add water and decoct for 3 times, the volume ratio of the material to the liquid is 1:10 each time, the temperature of each decoction is 100° C., and the decoction time is 1 hour each time, collect the decoction B of the 3 decoctions and combine it with the decoction A of step 1, and concentrate it at 75° C. and -0.05 MPa vacuum to a density of about 1.25 (60° C.) to obtain a concentrated clear paste;

[0096] Step 3: Granulation

[0097] Add bromelain and dextrin to the concentrated clear paste prepared in step 2, mix well, and then wet-extrude granulate. After that, the wet granulate is dried at 45° C. in a fluidized bed to obtain granules.

[0098] Step 4: Spray back the volatile oil

[0099] Spray the volatile oil collected in step 1 onto the granules obtained in step 3 while stirring. After the spraying is completed, place the granules in a sealed container for 24 hours and quickly divide the granules into small packages.

[0100] Example 2

[0101] A composition for preventing and treating gout in goslings, comprising the following raw materials in parts by weight:

[0102] 55 samples of Bletilla striata from Central Asia;

[0103] 70 parts cinnamon;

[0104] Eucommia ulmoides 50 parts;

[0105] 80 parts of Paper mulberry seeds;

[0106] White peony root 90 parts;

[0107] Astragalus 80 parts;

[0108] 40 portions of processed Chuanwu;

[0109] Angelica 60 parts;

[0110] Acorus calamus 60 parts;

[0111] 90 parts of litchi kernels;

[0112] Notopterygium wilfordii 50 portions;

[0113] rhubarb 55 parts;

[0114] Chicory root 90 parts;

[0115] Bromelain 50 parts.

[0116] The preparation method thereof comprises the following steps:

[0117] Step 1: Oil Extraction

[0118] After weighing each raw material by weight, cinnamon bark, calamus calamus, white peony root and rhubarb are crushed and passed through a No. 2 sieve to make coarse powder, and then soaked in water at a material-liquid mass ratio of 1:6, decocted at 100°C for 60 minutes, and the volatile oil, decoction A and medicinal residues are collected for later use.

[0119] Step 2: Decoction

[0120] Add Bletilla striata, Eucommia bark, Cuscuta australis, Astragalus, Aconiti Radix Angelicae Sinensis, Litchi Seed, Notopterygium wilfordii, and Chicory Root to the residue obtained in step 1, then add water and decoct for 3 times, wherein the volume ratio of the material to the liquid is 1:10 each time, the temperature of each decoction is 100° C., and the decoction time is 1 hour each time, and the decoction B of the 3 decoctions is collected and combined with the decoction A of step 1, and then concentrated to a density of about 1.25 (60° C.) at 75° C. and a vacuum degree of -0.05 MPa to obtain a concentrated clear paste;

[0121] Step 3: Granulation

[0122] Add bromelain and dextrin to the concentrated clear paste prepared in step 2, mix well, and then perform wet extrusion granulation. After that, the wet granules are dried at 45° C. in a fluidized bed to obtain granules;

[0123] Step 4: Spray back the volatile oil

[0124] Spray the volatile oil collected in step 1 onto the granules obtained in step 3 while stirring. After the spraying is completed, place the granules in a sealed container for 24 hours and quickly divide the granules into small packages.

[0125] Example 3

[0126] A Chinese medicinal granule for preventing and treating gout in goslings, comprising the following raw materials in parts by weight:

[0127] 75 samples of Bletilla striata from Central Asia;

[0128] 90 parts of cinnamon;

[0129] Eucommia ulmoides 70 parts;

[0130] 100 portions of Paper mulberry seeds;

[0131] 110 parts of white peony root;

[0132] Astragalus 100 parts;

[0133] 60 portions of processed Chuanwu;

[0134] Angelica sinensis 80 parts;

[0135] Acorus calamus 80 parts;

[0136] 90 parts of litchi kernels;

[0137] 70 portions of Notopterygium wilfordii;

[0138] 75 parts of rhubarb;

[0139] Chicory root 110 parts;

[0140] Bromelain 80 parts.

[0141] The preparation method thereof comprises the following steps:

[0142] Step 1: Oil Extraction

[0143] After weighing each raw material by weight, cinnamon bark, calamus calamus, white peony root and rhubarb are crushed and passed through a No. 2 sieve to make coarse powder, and then soaked in water at a material-liquid mass ratio of 1:6, decocted at 100°C for 60 minutes, and the volatile oil, decoction A and medicinal residues are collected for later use.

[0144] Step 2: Decoction

[0145] Add Bletilla striata, Eucommia bark, Cuscuta australis, Astragalus, Aconiti Radix Angelicae Sinensis, Litchi Seed, Notopterygium wilfordii, and Chicory Root to the residue obtained in step 1, then add water and decoct for 3 times, wherein the volume ratio of the material to the liquid is 1:10 each time, the temperature of each decoction is 100° C., and the decoction time is 1 hour each time, and the decoction B of the 3 decoctions is collected and combined with the decoction A of step 1, and then concentrated to a density of about 1.25 (60° C.) at 75° C. and a vacuum degree of -0.05 MPa to obtain a concentrated clear paste;

[0146] Step 3: Granulation

[0147] Add bromelain and dextrin to the concentrated clear paste prepared in step 2, mix well, and then perform wet extrusion granulation. After that, dry the obtained wet granules at 45° C. in a fluidized bed to obtain granules;

[0148] Step 4: Spray back the volatile oil

[0149] Spray the volatile oil collected in step 1 onto the granules obtained in step 3 while stirring. After the spraying is completed, place the granules in a sealed container for 24 hours and quickly divide the granules into small packages.

[0150] Comparative Example 1

[0151] A Chinese medicinal granule for preventing and treating gout in goslings, comprising the following raw materials in parts by weight:

[0152] 80 parts cinnamon;

[0153] Eucommia ulmoides 60 parts;

[0154] 90 parts of Paper mulberry seeds;

[0155] 100 parts of white peony root;

[0156] Astragalus 90 parts;

[0157] 50 portions of processed Chuanwu;

[0158] Angelica sinensis 70 parts;

[0159] Acorus calamus 70 parts;

[0160] 100 parts of litchi kernels;

[0161] 60 portions of Notopterygium wilfordii;

[0162] rhubarb 65 parts;

[0163] 100 parts chicory root;

[0164] Bromelain 65 parts.

[0165] The preparation method thereof comprises the following steps:

[0166] Step 1: Oil Extraction

[0167] After weighing each raw material by weight, cinnamon bark, calamus calamus, white peony root and rhubarb are crushed and passed through a No. 2 sieve to make coarse powder, and then soaked in water at a material-liquid mass ratio of 1:6, decocted at 100°C for 60 minutes, and the volatile oil, decoction A and medicinal residues are collected for later use.

[0168] Step 2: Decoction

[0169] Add Eucommia ulmoides, Cuscuta australis, Astragalus membranaceus, processed Chuanwu, Angelica sinensis, litchi seed, Notopterygium wilfordii, and chicory root to the medicinal residue obtained in step 1, then add water and decoct for 3 times, the volume ratio of material to liquid is 1:10 each time, the temperature of each decoction is 100° C., and the decoction time is 1 hour each time, collect the decoction B of the 3 decoctions and combine it with the decoction A of step 1, and concentrate it at 75° C. and -0.05 MPa vacuum degree to a density of about 1.25 (60° C.) to obtain a concentrated clear paste;

[0170] Step 3: Granulation

[0171] Add bromelain and dextrin to the concentrated clear paste prepared in step 2, mix well, and then perform wet extrusion granulation. After that, the wet granules are dried at 45° C. using a fluidized bed to obtain granules;

[0172] Step 4: Spray back the volatile oil

[0173] Spray the volatile oil collected in step 1 onto the granules obtained in step 3 while stirring. After the spraying is completed, place the granules in a sealed container for 24 hours and quickly divide the granules into small packages.

[0174] Comparative Example 2

[0175] A Chinese medicinal granule for preventing and treating gout in goslings, comprising the following raw materials in parts by weight:

[0176] 65 samples of Bletilla striata from Central Asia;

[0177] 80 parts cinnamon;

[0178] Eucommia ulmoides 60 parts;

[0179] 100 parts of white peony root;

[0180] Astragalus 90 parts;

[0181] 50 portions of processed Chuanwu;

[0182] Angelica sinensis 70 parts;

[0183] Acorus calamus 70 parts;

[0184] 100 parts of litchi kernels;

[0185] 60 portions of Notopterygium wilfordii;

[0186] rhubarb 65 parts;

[0187] 100 parts chicory root;

[0188] Bromelain 65 parts.

[0189] The preparation method thereof comprises the following steps:

[0190] Step 1: Oil Extraction

[0191] After weighing each raw material by weight, cinnamon bark, calamus calamus, white peony root and rhubarb are crushed and passed through a No. 2 sieve to make coarse powder, and then soaked in water at a material-liquid mass ratio of 1:6, decocted at 100°C for 60 minutes, and the volatile oil, decoction A and medicinal residues are collected for later use.

[0192] Step 2: Decoction

[0193] Add Bletilla striata, Eucommia bark, Astragalus membranaceus, processed Chuanwu, Angelica sinensis, litchi seed, Notopterygium wilfordii, and chicory root to the medicinal residue obtained in step 1, then add water and decoct for 3 times, the volume ratio of material to liquid is 1:10 each time, the temperature of each decoction is 100° C., and the decoction time is 1 hour each time, collect the decoction B of the 3 decoctions and combine it with the decoction A of step 1, and concentrate it at 75° C. and -0.05 MPa vacuum degree to a density of about 1.25 (60° C.) to obtain a concentrated clear paste;

[0194] Step 3: Granulation

[0195] Add bromelain and dextrin to the concentrated clear paste prepared in step 2, mix well, and then perform wet extrusion granulation. After that, the wet granules are dried at 45° C. in a fluidized bed to obtain granules;

[0196] Step 4: Spray back the volatile oil

[0197] Spray the volatile oil collected in step 1 onto the granules obtained in step 3 while stirring. After the spraying is completed, place the granules in a sealed container for 24 hours and quickly divide the granules into small packages.

[0198] Comparative Example 3

[0199] A Chinese medicinal granule for preventing and treating gout in goslings, comprising the following raw materials in parts by weight:

[0200] 65 samples of Bletilla striata from Central Asia;

[0201] 80 parts cinnamon;

[0202] Eucommia ulmoides 60 parts;

[0203] 90 parts of Paper mulberry seeds;

[0204] 100 parts of white peony root;

[0205] Astragalus 90 parts;

[0206] 50 portions of processed Chuanwu;

[0207] Angelica sinensis 70 parts;

[0208] Acorus calamus 70 parts;

[0209] 100 parts of litchi kernels;

[0210] 60 portions of Notopterygium wilfordii;

[0211] 100 parts chicory root;

[0212] Bromelain 65 parts.

[0213] The preparation method thereof comprises the following steps:

[0214] Step 1: Oil Extraction

[0215] After weighing each raw material by weight, cinnamon bark, calamus calamus and white peony root were crushed and passed through a No. 2 sieve to make coarse powder, and then soaked in water at a material-liquid mass ratio of 1:6, and decocted at 100°C for 60 minutes. The volatile oil, decoction A and medicinal residues were collected and set aside.

[0216] Step 2: Decoction

[0217] Add Bletilla striata, Eucommia bark, Cuscuta australis, Astragalus, Aconiti Radix Angelicae Sinensis, Litchi Seed, Notopterygium wilfordii, and Chicory Root to the residue obtained in step 1, then add water and decoct for 3 times, wherein the volume ratio of the material to the liquid is 1:10 each time, the temperature of each decoction is 100° C., and the decoction time is 1 hour each time, and the decoction B of the 3 decoctions is collected and combined with the decoction A of step 1, and then concentrated to a density of about 1.25 (60° C.) at 75° C. and a vacuum degree of -0.05 MPa to obtain a concentrated clear paste;

[0218] Step 3: Granulation

[0219] Add bromelain and dextrin to the concentrated clear paste prepared in step 2, mix well, and then perform wet extrusion granulation. After that, dry the wet granules at 45° C. in a fluidized bed to obtain granules;

[0220] Step 4: Spray back the volatile oil

[0221] Spray the volatile oil collected in step 1 onto the granules obtained in step 3 while stirring. After the spraying is completed, place the granules in a sealed container for 24 hours and quickly divide the granules into small packages.

[0222] Comparative Example 4

[0223] A Chinese medicinal granule for preventing and treating gout in goslings, comprising the following raw materials in parts by weight:

[0224] 65 samples of Bletilla striata from Central Asia;

[0225] 80 parts cinnamon;

[0226] Eucommia ulmoides 60 parts;

[0227] 90 parts of Paper mulberry seeds;

[0228] 100 parts of white peony root;

[0229] Astragalus 90 parts;

[0230] 50 portions of processed Chuanwu;

[0231] Angelica sinensis 70 parts;

[0232] 100 parts of litchi kernels;

[0233] 60 portions of Notopterygium wilfordii;

[0234] rhubarb 65 parts;

[0235] 100 parts chicory root;

[0236] 50-80 parts of bromelain.

[0237] The preparation method thereof comprises the following steps:

[0238] Step 1: Oil Extraction

[0239] After weighing each raw material by weight, cinnamon bark, white peony root and rhubarb are crushed and passed through a No. 2 sieve to make coarse powder, and then soaked in water at a material-liquid mass ratio of 1:6, decocted at 100°C for 60 minutes, and the volatile oil, decoction A and medicinal residues are collected for later use.

[0240] Step 2: Decoction

[0241] Add Bletilla striata, Eucommia bark, Cuscuta australis, Astragalus, Aconiti Radix Angelicae Sinensis, Litchi Seed, Notopterygium wilfordii, and Chicory Root to the residue obtained in step 1, then add water and decoct for 3 times, wherein the volume ratio of the material to the liquid is 1:10 each time, the temperature of each decoction is 100° C., and the decoction time is 1 hour each time, and the decoction B of the 3 decoctions is collected and combined with the decoction A of step 1, and then concentrated to a density of about 1.25 (60° C.) at 75° C. and a vacuum degree of -0.05 MPa to obtain a concentrated clear paste;

[0242] Step 3: Granulation

[0243] Add bromelain and dextrin to the concentrated clear paste prepared in step 2, mix well, and then perform wet extrusion granulation. After that, dry the obtained wet granules at 45° C. in a fluidized bed to obtain granules;

[0244] Step 4: Spray back the volatile oil

[0245] Spray the volatile oil collected in step 1 onto the granules obtained in step 3 while stirring. After the spraying is completed, place the granules in a sealed container for 24 hours and quickly divide the granules into small packages.

[0246] Comparative Example 5

[0247] A Chinese medicinal granule for preventing and treating gout in goslings, comprising the following raw materials in parts by weight:

[0248] 65 samples of Bletilla striata from Central Asia;

[0249] 80 parts cinnamon;

[0250] Eucommia ulmoides 60 parts;

[0251] 90 parts of Paper mulberry seeds;

[0252] 100 parts of white peony root;

[0253] Astragalus 90 parts;

[0254] 50 portions of processed Chuanwu;

[0255] Angelica sinensis 70 parts;

[0256] Acorus calamus 70 parts;

[0257] 100 parts of litchi kernels;

[0258] 60 portions of Notopterygium wilfordii;

[0259] rhubarb 65 parts;

[0260] 100 parts chicory root;

[0261] The preparation method thereof comprises the following steps:

[0262] Step 1: Oil Extraction

[0263] After weighing each raw material by weight, cinnamon bark, calamus calamus, white peony root and rhubarb are crushed and passed through a No. 2 sieve to make coarse powder, and then soaked in water at a mass ratio of coarse powder to water of 1:6, and decocted at 100°C for 60 minutes, and the volatile oil, decoction A and medicinal residues are collected for later use.

[0264] Step 2: Decoction

[0265] Add Bletilla striata, Eucommia bark, Cuscuta australis, Astragalus, Aconiti Radix Angelicae Sinensis, Litchi Seed, Notopterygium wilfordii, and Chicory Root to the residue obtained in step 1, then add water and decoct for 3 times, wherein the volume ratio of the material to the liquid is 1:10 each time, the temperature of each decoction is 100° C., and the decoction time is 1 hour each time, and the decoction B of the 3 decoctions is collected and combined with the decoction A of step 1, and then concentrated to a density of about 1.25 (60° C.) at 75° C. and a vacuum degree of -0.05 MPa to obtain a concentrated clear paste;

[0266] Step 3: Granulation

[0267] Add dextrin to the concentrated clear paste prepared in step 2, mix well, and then perform wet extrusion granulation. After that, dry the wet granules at 45° C. in a fluidized bed to obtain granules.

[0268] Step 4: Spray back the volatile oil

[0269] Spray the volatile oil collected in step 1 onto the granules obtained in step 3 while stirring. After the spraying is completed, place the granules in a sealed container for 24 hours and quickly divide the granules into small packages.

[0270] Comparative Example 6

[0271] A composition for preventing and treating gout in goslings, comprising the following raw materials in parts by weight:

[0272] The preparation method thereof comprises the following steps:

[0273] Step 1: Decoction

[0274] After weighing each raw material by weight, cinnamon bark, calamus calamus, white peony root and rhubarb are crushed and passed through a No. 2 sieve to make coarse powder, then soaked in water, and then Bletilla striata, Eucommia bark, Cuscuta australis, Astragalus membranaceus, Radix Angelicae Sinensis, Litchi seed, Notopterygium wilfordii and chicory root are added thereto, and decocted for 3 times, the material-liquid mass ratio is 1:10 in each decoction, the decoction temperature is 100°C, and the decoction time is 1 hour each time, and the decoctions of the 3 decoctions are collected and concentrated to a density of about 1.25 (60°C) at 100°C and a vacuum degree of -0.05 MPa to obtain a concentrated clear paste;

[0275] Step 2: Granulation

[0276] Add bromelain and dextrin to the concentrated clear paste prepared in step 2, mix well, and then perform wet extrusion granulation. After that, dry the wet granules at 45° C. using a fluidized bed to obtain granules; place them in a sealed container for 24 hours and quickly package them.

[0277] Effect example: Clinical trial

[0278] 8,000 breeding geese developed watery diarrhea and white loose feces at 11 days of age. The feed intake was normal and they huddled together. At 12 days, one percent of them were found to be paralyzed, with swelling of the toe and knee joints and red spots, which gradually increased; about 40 geese died every day. Autopsy showed that the dead geese were severely dehydrated, with severe urate deposits in the liver and abdominal cavity, enlarged kidneys with a mottled appearance, and enlarged ureters filled with white urate. According to the DB37 / T4459-2021 Technical Specifications for Diagnosis of Goose Astrovirus Infection, the case was caused by goose astrovirus infection and was diagnosed as gosling gout caused by goose astrovirus infection.

[0279] After the diagnosis of gout in goslings caused by goose astrovirus infection was confirmed, 450 goslings with similar symptoms were selected and randomly divided into 9 groups; 50 goslings in each group were raised in isolation, and the feeding and management methods remained consistent. The following treatment plan was used for medication, and the development of the disease after medication was observed and recorded. The mortality rate, cure rate, and effectiveness rate were statistically analyzed. The results are shown in Table 1.

[0280] Grouping:

[0281] Experimental group: using the Chinese medicine granules prepared in Example 1, 100g of Chinese medicine granules mixed with 200kg of feed, and used for 5 consecutive days;

[0282] A comparison group: using the Chinese medicine granules prepared in Comparative Example 1, 100g of Chinese medicine granules were mixed with 200kg of feed and used for 5 consecutive days;

[0283] Comparative Group 2: Using the Chinese medicine granules prepared in Comparative Example 2, 100g of Chinese medicine granules were mixed with 200kg of feed and used for 5 consecutive days;

[0284] Three groups were compared: the Chinese medicine granules prepared in Comparative Example 3 were used, 100 g of Chinese medicine granules were mixed with 200 catties of feed, and used for 5 consecutive days;

[0285] Four groups were compared: the Chinese medicine granules prepared in Comparative Example 4 were used, 100 g of Chinese medicine granules were mixed with 200 catties of feed, and used for 5 consecutive days;

[0286] Comparison of five groups: using the Chinese medicine granules prepared in Comparative Example 5, 100g of Chinese medicine granules mixed with 200kg of feed, and used for 5 consecutive days;

[0287] Comparative Group 6: Using the Chinese medicine granules prepared in Comparative Example 6, 100g of Chinese medicine granules were mixed with 200kg of feed and used for 5 consecutive days;

[0288] Comparison of Group 7: On the first day of treatment, the goose gout yolk antibody purchased from the market was injected, 1 ml per goose, and one injection was sufficient;

[0289] Blank control group: no drug treatment was performed.

[0290] For gosling gout, the identification characteristics of each indicator after medication are as follows:

[0291] Death: The inclusion of geese that died naturally during the treatment process;

[0292] Cured: Patients are considered cured if they have normal food intake, good mental state, and disappearance of lameness or paralysis, and diarrhea all meet these three criteria.

[0293] Effective: Feed intake, mental state, lameness or paralysis, diarrhea as long as any two of the above indicators return to normal, can be included in the effective category.

[0294] Table 1

[0295] Effectiveness% Cure rate% mortality rate% Example 1 100 96 0 Comparative Example 1 88 68 12 Comparative Example 2 90 68 10 Comparative Example 3 78 74 22 Comparative Example 4 72 70 28 Comparative Example 5 68 66 32 Comparative Example 6 62 52 38 Conventional medication 96 60 4 Blank control 44 12 56

[0296] As can be seen from the above data, Example 1 is the best group in terms of both effective rate and cure rate. The cure rate, effective rate and mortality rate of Comparative Examples 1 and 2 are not much different, but the cure rate and mortality rate are significantly reduced compared with Example 1. Because Bletilla striata and Cuscuta chinensis can enhance liver and kidney function, strengthen metabolism, reduce liver and kidney damage, fundamentally improve the cure rate, and reduce the mortality rate. The effective rate and mortality rate of Comparative Examples 3 and 4 are significantly reduced because Rhubarb and Acorus calamus have the functions of removing dampness and dredging collaterals, detoxifying and detoxifying, promoting uric acid metabolism, and detoxifying and going out, so they can directly affect the antiviral effect. In addition, because Bletilla striata and Cuscuta chinensis are added, the cure rate is relatively high, and all effective ones can be cured quickly. Comparative Example 5 is a prescription group without the addition of bromelain, which can effectively eliminate inflammation, improve the clinical symptoms of gout in goslings, and then improve the cure rate and reduce the mortality rate. Comparative Example 6 does not add volatile oil, and the antiviral effect of the entire prescription is significantly reduced. Comprehensive analysis shows that without volatile oils and antiviral ingredients such as rhubarb and calamus, the effective rate is significantly reduced and the mortality rate is significantly increased. Without Bletilla striata and Cuscuta australis, which are traditional Chinese medicine ingredients that nourish the liver and kidneys and enhance liver and kidney functions, the cure rate is relatively the lowest. Although it can effectively alleviate clinical symptoms, the liver and kidney damage is so severe that it cannot be completely cured.

[0297] The above-described embodiments are only preferred embodiments of the present invention, and are not exhaustive of the feasible implementations of the present invention. For those skilled in the art, any obvious changes made thereto without departing from the principles and spirit of the present invention should be considered to be included in the scope of protection of the claims of the present invention.

Claims

1. A composition for preventing and treating gout in goslings, characterized in that: The following raw materials are included in parts by weight: Bletilla striata 55-75 copies; 70-90 parts cinnamon; Eucommia ulmoides 50-70 parts; 80-100 parts of paper mulberry seeds; 90-110 parts of white peony root; 80-100 parts of Astragalus; 40-60 portions of processed Chuanwu; 60-80 parts of Chinese Angelica; 60-80 parts of Acorus calamus; 90-110 parts of litchi kernels; 50-70 parts of Notopterygium wilfordii; 55-75 parts rhubarb; Chicory root 90-110 parts; 50-80 parts of bromelain.

2. A composition for preventing and treating gout in goslings according to claim 1, characterized in that: The following raw materials are included in parts by weight: 65 samples of Bletilla striata from Central Asia; 80 parts cinnamon; Eucommia ulmoides 60 parts; 90 parts of Paper mulberry seeds; 100 parts of white peony root; Astragalus 90 parts; 50 portions of processed Chuanwu; Angelica sinensis 70 parts; Acorus calamus 70 parts; 100 parts of litchi kernels; 60 portions of Notopterygium wilfordii; rhubarb 65 parts; 100 parts chicory root; 50-80 parts of bromelain.

3. A Chinese medicine preparation prepared from the composition for preventing and treating gout in goslings according to any one of claims 1-2, wherein the Chinese medicine preparation is an oral preparation, and the oral preparation includes one or more of decoctions, granules, and syrups.

4. A Chinese medicine granule prepared from the composition for preventing and treating gout in goslings according to any one of claims 1-2.

5. A method for preparing the Chinese medicine granules as claimed in claim 4, characterized in that: The steps include: Step 1: Oil Extraction After weighing each raw material by weight, cinnamon bark, calamus calamus, white peony root and rhubarb are crushed and passed through a No. 2 sieve to make coarse powder, then soaked in water and boiled, volatile oil is collected, and the decoction A and the residue are set aside; Step 2: Decoction Add Bletilla striata, Eucommia bark, Cuscuta australis, Astragalus, Aconiti Radix Angelicae Sinensis, Litchi Seed, Notopterygium wilfordii, and Chicory Root to the residue obtained in step 1, add water and boil for 2-3 times, collect decoction B, combine it with decoction A in step 1, and concentrate it to obtain a concentrated clear paste; Step 3: Granulation Add bromelain and dextrin to the concentrated clear paste prepared in step 2, mix well, and then wet-extrude and granulate. After the wet granules are dried, granules are obtained. Step 4: Spray back the volatile oil Spray the volatile oil collected in step 1 onto the granules obtained in step 3 while stirring. After the spraying is completed, place the granules in a sealed container for 24 hours and quickly divide the granules into small packages.

6. The method for preparing a Chinese medicine granule according to claim 5, characterized in that: During decoction in step 1, the mass ratio of material to liquid is 1:4-6; The decoction temperature of step 1 is 100° C. and the decoction time is 40-60 min.

7. The method for preparing a Chinese medicine granule according to claim 5, characterized in that: In step 2, each time of decoction, the volume ratio of the material to the liquid is 1:8-10; the temperature of each decoction is 100° C., and the time of each decoction is 60-90 minutes; In step 2, the concentration is carried out at a temperature of 70-80° C. and a vacuum degree of -0.05 MPa to a density of 1.2-1.

3.

8. The method for preparing a Chinese medicine granule according to claim 5, characterized in that: In step 3, the drying is performed using a fluidized bed, and the drying temperature is less than or equal to 45°C.