A Chinese medicine composition for treating functional abdominal distension and its use

Abstract

The invention discloses a Chinese medicine composition for treating functional abdominal distension and its application. The composition comprises 18-22 parts of rose, 18-22 parts of cyperus rotundus, 8-12 parts of sandalwood, 4-6 parts of agarwood, 13-17 parts of julibrissin bark, 13-17 parts of bergamot, 18-22 parts of lily and 5-7 parts of liquorice by weight. The Chinese medicine raw materials can be soaked in cold water, first decocted and second decocted, and the residues are filtered out to obtain a decoction, and the decoction can also be prepared into Chinese medicine granules. The medicine has a fresh fragrance without being dry and strong, can relieve stagnation without consuming qi, can relieve depression and calm the mind, can soften the liver and relieve liver depression, can wake up the spleen and promote spleen stagnation, and can be used to treat functional abdominal distension with remarkable curative effect. The total effective rate of syndromes and main symptoms can reach more than 90%.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating functional abdominal distension and a use thereof. Background Art

[0002] Functional bloating is different from the feeling of fullness and discomfort after eating, with or without a measurable increase in abdominal circumference. Functional bloating does not belong to other functional gastrointestinal diseases such as irritable bowel syndrome, nor does it belong to functional gastroduodenal diseases such as functional dyspepsia. Functional bloating is a recurring subjective feeling of abdominal distension, with abdominal distension and (or) abdominal distension as the main symptoms, and is a functional intestinal disorder without organic or other functional gastrointestinal lesions.

[0003] Although functional abdominal distension does not cause much harm to human life, it has a great impact on people's emotions, life and work, forcing patients to seek medical treatment repeatedly and consuming a lot of medical resources. According to domestic research, the prevalence of functional abdominal distension is about 22.25%, and it is more common in women. The incidence of functional abdominal distension has an increasing trend year by year, so it has attracted more and more attention. Not only that, there are more hidden factors that force patients to seek medical treatment repeatedly and fail to be cured for a long time. According to the inventor's many years of research experience in functional gastrointestinal diseases, it is found that patients with functional gastrointestinal diseases are hesitant and suspicious, and most doctors do not easily diagnose patients' symptoms as functional rather than organic, which leads to patients not believing in the diagnosis of no organic disease, but thinking that they are sick but not found, so they go for repeated examinations and treatments.

[0004] Traditional Chinese medicine has advantages in the treatment of refractory functional abdominal distension. According to the clinical manifestations of functional abdominal distension, functional abdominal distension can be classified into the categories of "fullness", "bloating" and "aggregation" in traditional Chinese medicine. In clinical practice, it is found that traditional Chinese medicine can effectively improve the clinical symptoms of refractory functional abdominal distension, and the long-term efficacy is relatively stable. However, functional abdominal distension is often accompanied by symptoms such as poor appetite, belching, increased flatulence, abdominal fullness or bloating, and autonomous bowel sounds, resulting in a variety of syndromes identified by different syndrome differentiation methods, resulting in the problem of difficult to repeat the efficacy. Summary of the invention

[0005] The purpose of the present invention is to provide a Chinese medicine composition for treating functional abdominal distension, identify the basic pathogenesis of functional abdominal distension according to the method of main symptom differentiation, determine the treatment principles based on the basic pathogenesis, determine special prescriptions and special medicines based on the treatment principles to achieve precise treatment and obtain significant therapeutic effects, thereby avoiding the problem of numerous syndromes and difficult to repeat therapeutic effects identified by other syndrome differentiation methods.

[0006] The technical solution adopted by the present invention provides a traditional Chinese medicine composition for treating functional abdominal distension. The key is that, calculated by weight, the traditional Chinese medicine composition consists of 18 to 22 parts of rose flowers, 18 to 22 parts of cyperus rotundus, 8 to 12 parts of sandalwood, 4 to 6 parts of agarwood, 13 to 17 parts of julibrissin bark, 13 to 17 parts of bergamot, 18 to 22 parts of lily and 5 to 7 parts of liquorice.

[0007] Preferably, the above-mentioned traditional Chinese medicine composition for treating functional abdominal distension is composed, by weight, of 20 parts of rose, 20 parts of cyperus rotundus, 10 parts of sandalwood, 5 parts of agarwood, 15 parts of julibrissin bark, 15 parts of bergamot, 20 parts of lily and 6 parts of licorice.

[0008] Furthermore, the above-mentioned Chinese medicine composition is soaked in cold water for 30 min to 60 min, simmered for 20 min to 30 min from the beginning of boiling, and simmered for 15 min to 20 min, and the residue is filtered out to obtain a decoction, which is taken orally twice a day, morning and evening.

[0009] The use of a traditional Chinese medicine composition for treating functional abdominal distension mainly lies in that the basic pathogenesis of functional abdominal distension is determined to be liver depression and spleen stagnation, and the composition is used for treating functional abdominal distension.

[0010] Compared with the prior art, the present invention has the following beneficial effects:

[0011] The present invention adopts the main symptom differentiation, which greatly improves the accuracy of the differentiation. Functional gastrointestinal disease is mainly based on symptoms, and each disease has its main symptoms, which is more suitable for the main symptom differentiation. This is because grasping the key few is grasping the outline, and the main symptoms are differentiated and treated, the basic pathogenesis of the main symptoms can be identified, and the medicine prescription can be formulated according to the basic pathogenesis, so as to avoid the proliferation of syndromes and people being confused. The basic pathogenesis summarizes the essence of the disease, which is the outline and the root, has high directionality and comprehensiveness, plays the role of simplifying the complex, and avoids repeated classification that is difficult to master.

[0012] The present invention has carried out a deep etiology and pathogenesis analysis on the main symptoms of functional abdominal distension, which is more effective. The present invention believes that the causes of the main symptoms are mostly related to anxiety and depression, which belong to psychosomatic diseases and are most closely related to emotions. This is related to the increased competitive pressure in modern society and the fact that people are in a state of high psychological tension, which in turn leads to an increase in psychological activities such as anger and worry. Anger hurts the liver, thinking hurts the spleen, the liver fails to dredge and release, wood crosses the earth, and affects the spleen's transportation and transformation; thinking causes qi stagnation, excessive thinking, and the spleen is also affected by thinking. Abdominal distension, belching, loss of appetite, intestinal rumbling, etc. occur when the spleen fails to function properly, the stomach fails to harmonize and descend, the middle jiao is blocked, and the triple jiao is blocked.

[0013] The main symptoms of functional abdominal distension are abdominal distension and distention. According to the causes, the psychological characteristics of the patient and the characteristics of the abdominal distension, the basic pathogenesis is liver depression and spleen stagnation. The treatment principle for the basic pathogenesis is to soften the liver and invigorate the spleen.

[0014] The liver-softening and spleen-awakening soup disclosed by the present invention has a refreshing and non-drying medicinal fragrance, relieves stagnation without consuming qi, relieves depression and calms the mind, softens the liver and relieves liver depression, wakes up the spleen and moves spleen stagnation, harmonizes the liver and spleen, each performs its own function, rises and falls in an orderly manner, and the three energizers are unobstructed, and abdominal distension and abdominal swelling are eliminated. The Chinese medicine composition of the present invention is prepared into Chinese medicine granules, which are more convenient to carry and convenient for patients to take daily.

[0015] Explanation of the prescription of the present invention: Rose flower is the main medicine for softening the liver and invigorating the spleen. "Compendium of Materia Medica" records that "Rose flower has the strongest fragrance, which is clear but not turbid, harmonious but not fierce. It softens the liver and stomach, promotes the flow of qi and activates blood circulation, and relieves stagnation without any disadvantages of being pungent, warm, strong or dry. It is the most effective and the most docile among the qi-regulating medicines, and it is unmatched among all the aromatic products." This shows that rose flower has the functions of softening the liver and invigorating the spleen, which corresponds to the basic pathogenesis of functional abdominal distension and hits the nail on the head. Cyperus rotundus, agarwood, and sandalwood are all auxiliary drugs. Cyperus rotundus belongs to the liver, spleen, and triple burner meridians, and can relieve liver qi, relieve depression, and regulate qi. The Compendium of Materia Medica believes that Cyperus rotundus "benefits the triple burner and relieves six depressions", and the Bencao Qiuzhen believes that Cyperus rotundus "is specifically used to relieve depression and disperse qi", and the Bencao Zhengyi believes that Cyperus rotundus "has a very strong pungent taste and a strong fragrance, all of which are used by qi, so it is specially used to treat qi stagnation", and the Depei Materia Medica believes that Cyperus rotundus "is paired with agarwood to raise and lower all qi. It is paired with sandalwood to regulate qi and wake up the spleen." It can be seen that Cyperus rotundus, sandalwood, and agarwood can relieve liver qi, relieve depression, wake up spleen stagnation, and regulate rise and fall. It is most appropriate to assist rose in softening the liver and waking up the spleen to treat functional abdominal distension. Albizzia bark is good at relieving liver depression; Buddha's hand is aromatic and wakes up the spleen, relieves liver depression; lily nourishes yin, clears the heart and calms the mind, and lily can also relieve the dryness of other aromatic drugs. The three are all auxiliary drugs. Licorice harmonizes all drugs as a messenger. The main and auxiliary drugs are coordinated to achieve the effects of softening the liver and invigorating the spleen, promoting qi and removing bloating. At the same time, due to the characteristics of the drug of the present invention being light and not dry, the patient's resistance to taking bitter medicine is reduced. DETAILED DESCRIPTION

[0016] The present invention provides a Chinese medicine composition for treating functional abdominal distension and its use. The technical scheme in the embodiments of the present invention is clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0017] Embodiment 1

[0018] A traditional Chinese medicine composition for treating functional abdominal distension, comprising the following traditional Chinese medicines: 20 g of rose flower, 20 g of cyperus rotundus, 10 g of santalinum, 5 g of agarwood, 15 g of julibrissin bark, 15 g of bergamot, 20 g of lily, and 6 g of liquorice.

[0019] Soak the above Chinese medicinal materials in cold water for 30 minutes, and simmer them on low heat from the moment the pot boils, i.e. the first decocting time is 20 minutes; the second decocting time is 15 minutes, and a total of 300 mL of juice is obtained, which is called "Ganrouxingpixin Decoction".

[0020] Take orally twice a day, morning and evening. One course of treatment is four weeks.

[0021] Embodiment 2

[0022] A traditional Chinese medicine composition for treating functional abdominal distension, comprising the following traditional Chinese medicines: 18 g of rose flower, 22 g of cyperus rotundus, 12 g of santalinum, 4 g of agarwood, 13 g of julibrissin bark, 17 g of bergamot, 18 g of lily, and 6 g of liquorice.

[0023] Soak the above Chinese medicinal materials in cold water for 60 min, and simmer over low heat for 25 min from the moment the water boils; 20 min for the second decocting, and take 320 mL of juice in total.

[0024] Take orally twice a day, morning and evening. One course of treatment is four weeks.

[0025] Embodiment 3

[0026] A traditional Chinese medicine composition for treating functional abdominal distension, comprising the following traditional Chinese medicines: 22 g of rose flower, 18 g of cyperus rotundus, 8 g of santalinum, 6 g of agarwood, 17 g of julibrissin bark, 13 g of bergamot, 22 g of lily, and 5 g of liquorice.

[0027] Soak the above Chinese medicinal materials in cold water for 45 minutes, and then simmer for 30 minutes from the beginning of the boiling process; the second decocting time is 18 minutes, and a total of 310 mL of juice is collected.

[0028] Take orally twice a day, morning and evening. One course of treatment is four weeks.

[0029] Embodiment 4

[0030] A traditional Chinese medicine composition for treating functional abdominal distension, comprising the following traditional Chinese medicines, measured by weight: 20 parts of rose flowers, 20 parts of cyperus rotundus, 10 parts of sandalwood, 5 parts of agarwood, 15 parts of julibrissin bark, 15 parts of bergamot, 20 parts of lily, and 6 parts of liquorice.

[0031] Weigh the Chinese medicinal raw materials according to the above ratio, crush them for later use; add 2 times the amount of water to soak for 2 hours, reflux extraction 3 times, filter to obtain the concentrated solution, add dextrin, stir evenly, spray dry, and obtain Chinese medicinal granules through dry granulation, which are called "Gan Rou Xing Pi Granules".

[0032] The effect of the Chinese medicine composition for treating functional abdominal distension provided by the present invention is described below.

[0033] 1. General Information

[0034] 110 patients with functional abdominal distension were randomly divided into treatment group (55 cases) and control group (55 cases). There were 18 males and 27 females in the treatment group, with an average age of 35.2 years and an average course of disease of 30.1 months; there were 17 males and 28 females in the control group, with an average age of 34.7 years and an average course of disease of 28.5 months. The clinical data of the two groups of patients were statistically processed and there was no significant difference, so they were judged to be comparable.

[0035] 2. Diagnosis and exclusion criteria

[0036] 2.1 Diagnostic criteria

[0037] According to the Rome IV diagnostic criteria, functional abdominal distension must include both of the following:

[0038] (1) Recurrent abdominal distension and / or bloating, occurring on average at least once a week, with the bloating and / or bloating being more prominent than other symptoms.

[0039] (2) Does not meet the diagnostic criteria for irritable bowel syndrome, functional constipation, functional diarrhea, or postprandial discomfort syndrome. Abdominal distension may be accompanied by mild abdominal pain and mild defecation disorder.

[0040] Symptoms occurred for at least 6 months before diagnosis and met the above diagnostic criteria in the past 3 months.

[0041] 2.2 Efficacy evaluation and judgment criteria

[0042] According to the criteria for treating liver-stomach disharmony with new Chinese medicines in the Guiding Principles for Clinical Research of New Chinese Medicines, different scores were assigned to the severity of symptoms such as abdominal distension, belching, loss of appetite, and abdominal rumbling. The changes in scores before and after treatment were statistically analyzed and calculated using the nimodipine method. The calculation formula was: [(score before treatment - score after treatment) ÷ score before treatment] × 100%.

[0043] 2.2.1 Criteria for judging the efficacy of syndromes

[0044] (1) Clinical recovery: symptoms and signs disappear or almost disappear, and the syndrome score decreases by ≥95%.

[0045] (2) Markedly effective: symptoms and signs were significantly improved, with the syndrome score reduced by ≥70%.

[0046] (3) Effective: symptoms and signs improved, and the syndrome score decreased by ≥30%.

[0047] (4) Ineffective: There is no significant improvement in symptoms and signs or they may even worsen, and the symptom score decreases by less than 30%.

[0048] 2.2.2 Evaluation of efficacy of main symptoms

[0049] (1) Clinical control: major symptoms disappear or almost disappear, with a score reduction of ≥95%.

[0050] (2) Significant improvement: The main symptom score decreased by ≥70%.

[0051] (3) Improvement: the main symptom score decreased by ≥30%.

[0052] (4) Ineffective: The main symptom score decreased by less than 30%.

[0053] 2.2.3 Statistical methods

[0054] The medical statistics software SPSS 22.0 was used for statistical analysis, and the measurement data and count data were analyzed using t-test and X-test, respectively. 2 Test, P < 0.05 indicates a significant difference, which is statistically significant.

[0055] 3. Treatment methods

[0056] The treatment group was administered with the Liver-Softening and Spleen-Revitalizing Decoction described in Example 1 of the present invention, 150 mL each time, twice a day, half an hour before breakfast and dinner.

[0057] The control group was treated with mosapride citrate tablets, 5 mg at a time (specification 5 mg / tablet), three times a day, half an hour before meals.

[0058] The treatment and control groups had a course of 4 weeks, and the symptoms were scored before and after treatment.

[0059] 4. Treatment results

[0060] After 4 weeks of treatment, the total effective rates of syndromes and main symptoms were analyzed respectively.

[0061] Explanation of the dropout situation in the two groups:

[0062] All patients in the treatment group and the control group completed the clinical trial without any dropout records.

[0063] (1) The total effective rate of the treatment group was 95%, while that of the control group was 71%. It can be seen that the treatment group was better than the control group. 2 The results showed that *P<0.05, indicating that the statistical results were significant. See Table 1 for specific results.

[0064] Total effective rate = [(number of clinically cured cases + number of markedly effective cases + number of effective cases) ÷ total number of cases] × 100%.

[0065] Table 1: Comparison of the efficacy of TCM symptoms after treatment

[0066] Group Number of cases Clinical recovery Significant effect efficient invalid Total Effectiveness Treatment Group 55 cases 27 cases 18 cases 7 cases 3 cases 95% Control group 55 cases 10 cases 16 cases 13 cases 16 cases 71%

[0067] (2) The total effective rate of the main symptoms in the treatment group was 91%, while that in the control group was 69%. It can be seen that the treatment group was better than the control group. 2 The results showed that *P<0.05, indicating that the statistical results were significant. See Table 2 for specific results.

[0068] Total effective rate = [(number of cases under clinical control + number of cases with significant improvement + number of cases with improvement) ÷ total number of cases] × 100%.

[0069] Table 2 Comparison of efficacy of main symptoms after treatment

[0070] Group Number of cases Clinical control Significant progress progress invalid Total Effectiveness Treatment Group 55 cases 32 cases 10 cases 8 cases 5 cases 91% Control group 55 cases 14 cases 14 cases 10 cases 17 cases 69%

[0071] In summary, after 4 weeks of treatment, the total effective rate of syndromes and main symptoms in the treatment group was higher than that in the control group, and both reached more than 90%. This shows that the principle of "softening the liver and awakening the spleen" treatment for the basic pathogenesis, and the Rougan Xingpi Decoction determined by it, have clear veins, are closely linked, and have significant effects.

Claims

1. A Chinese medicine composition for treating functional abdominal distension, characterized in that: The invention comprises, by weight, 18 to 22 parts of roses, 18 to 22 parts of cyperus rotundus, 8 to 12 parts of sandalwood, 4 to 6 parts of agarwood, 13 to 17 parts of julibrissin bark, 13 to 17 parts of bergamot, 18 to 22 parts of lilies and 5 to 7 parts of liquorice.

2. A Chinese medicine composition for treating functional abdominal distension according to claim 1, characterized in that: The composition is composed of 20 parts of rose, 20 parts of cyperus, 10 parts of santalin, 5 parts of agarwood, 15 parts of julibrissin bark, 15 parts of bergamot, 20 parts of lily and 6 parts of liquorice by weight.

3. A Chinese medicine composition for treating functional abdominal distension according to claim 1, characterized in that: Soak the Chinese medicine composition in cold water for 30min-60min, simmer for 20min-30min on low heat from the moment the pot boils, simmer for 15min-20min, filter out the residue to obtain a decoction, and take it orally twice a day, morning and evening.