Traditional Chinese medicine composition for treating upper respiratory tract inflammation and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating upper respiratory tract inflammation and a preparation method thereof, and relates to the technical field of traditional Chinese medicine compositions. According to the traditional Chinese medicine composition for treating the upper respiratory tract inflammation and the preparation method thereof, the burdock is used as a monarch drug for dispelling wind and heat, promoting eruption and relieving sore throat, and detoxifying and dispersing swelling; mulberry leaves, fructus viticis and cicada slough are used as ministerial drugs to dispel wind and heat, clear lung and moisten dryness, and clear liver and improve eyesight; radix bupleuri, duckweed, bulbus fritillariae cirrhosae, caulis bambusae in taeniam and radix puerariae are used as adjuvant drugs for clearing superficies and abating fever, soothing liver-qi stagnation, ascending up yang and sinking qi, inducing sweat and dispelling exogenous evils, promoting eruption and relieving itching, inducing diuresis and relieving swelling, clearing heat and eliminating phlegm, moistening lung and relieving cough, and removing stasis and relieving swelling; honeysuckle, dandelion, inula flower and the like are used as conductant drugs to dispel wind and heat, clear away heat and toxic materials, promote diuresis and treat stranguria, depress qi and reduce phlegm, calm adverse-rising energy and arrest vomiting and the like, all the drugs are reasonably matched, and the traditional Chinese medicine has the effects of dispelling wind and heat, promoting eruption and relieving sore throat, detoxifying and dispersing swelling, relieving itching and inducing diuresis, depressing qi and reducing phlegm, calm adverse-rising energy and arrest vomiting and the like, and is good in curative effect, short in treatment course and free of toxic and side effects.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine compositions, in particular to a Chinese medicine composition for treating upper respiratory tract inflammation and a preparation method thereof. Background Art

[0002] 70% to 80% of upper respiratory tract inflammation is caused by viruses. These include rhinovirus, coronavirus, adenovirus, influenza and parainfluenza virus, respiratory syncytial virus, echovirus, coxsackievirus, etc. Another 20% to 30% of upper respiratory infections are caused by bacteria. Bacterial infection can be direct infection or secondary to viral infection, with hemolytic streptococci being the most common, followed by Haemophilus influenzae, pneumococcus, staphylococci, etc., and occasionally Gram-negative bacteria. Various causes that lead to reduced systemic or local respiratory defense functions, such as cold, rain, climate change, excessive fatigue, etc., can cause viruses or bacteria that already exist in the upper respiratory tract or invade from the outside to multiply rapidly, thereby inducing this disease. Patients who are old, young, weak, immunocompromised, or have chronic respiratory diseases are susceptible. The treatment of upper respiratory tract inflammation should distinguish the type of inflammation, and both Western and Chinese medicines can be used. Traditional Chinese medicine is used to treat upper respiratory tract infections, and it is very popular because of its small side effects and good efficacy.

[0003] The existing traditional Chinese medicines for treating upper respiratory tract inflammation have poor efficacy and take a long time to take effect. They cannot fundamentally improve the patient's immunity and enhance the patient's disease resistance, which is very unfavorable for the promotion of traditional Chinese medicine compositions. Summary of the invention

[0004] 1. Technical issues to be resolved

[0005] In view of the deficiencies of the prior art, the present invention provides a Chinese medicine composition for treating upper respiratory tract inflammation and a preparation method thereof, wherein the Chinese medicine prescription treats sore throat and other upper respiratory tract inflammations, and the main functions of the Chinese medicine prescription are: dispelling wind and heat, relieving sore throat and rash, relieving fever and diuresis, detoxifying and antibacterial. Indications: exogenous wind-heat, sore throat, pharyngitis, epiglottitis, tonsillitis, wind-heat cough and asthma, herpes virus invasion, etc. Chinese medicine treatment focuses on treating both the symptoms and the root causes, which can fundamentally improve the patient's immunity and enhance the patient's disease resistance.

[0006] (II) Technical solution

[0007] To achieve the above objectives, the present invention is implemented through the following technical scheme: a traditional Chinese medicine composition for treating upper respiratory tract inflammation, comprising the following components by weight: 5-10g of burdock seeds, 5-10g of cicada shells, 5-10g of mulberry leaves, 5-10g of vitex rotundus, 5-10g of bupleurum, 5-10g of duckweed, 10-15g of fritillaria cirrhosa, 5-10g of bamboo shavings, 10-40g of kudzu root, 10-50g of honeysuckle, 10-50g of dandelion and 3-9g of inula flower.

[0008] Preferably, the following components are included by weight: 7g burdock seeds, 7g cicada shells, 7g mulberry leaves, 7g vitex seeds, 7g bupleurum, 7g duckweed, 13g fritillaria cirrhosa, 7g bamboo shavings, 25g kudzu root, 25g honeysuckle, 30g dandelion and 6g inula flower.

[0009] Preferably, the following components are included by weight: 5g of burdock seeds, 5g of cicada shells, 5g of mulberry leaves, 5g of vitex rotundifolia, 5g of bupleurum, 5g of duckweed, 10g of fritillaria cirrhosa, 5g of bamboo shavings, 10g of kudzu root, 10g of honeysuckle, 10g of dandelion and 3g of inula flower.

[0010] Preferably, the following components are included by weight: 10g of burdock seeds, 10g of cicada shells, 10g of mulberry leaves, 10g of vitex rotundus, 10g of bupleurum, 10g of duckweed, 15g of fritillaria cirrhosa, 10g of bamboo shavings, 40g of kudzu root, 50g of honeysuckle, 50g of dandelion and 9g of inula flower.

[0011] Preferably, the mulberry leaves have no insect holes on the surface and have a lustrous and rich leaf texture.

[0012] The present invention also provides a method for preparing a Chinese medicine composition for treating upper respiratory tract inflammation, which specifically comprises the following steps:

[0013] S1. First, weigh the required weight portions of burdock seeds, cicada shells, mulberry leaves, vitex rotundifolia, bupleurum, duckweed, fritillaria cirrhosa, bamboo shavings, kudzu root, honeysuckle, dandelion and inula flower;

[0014] S2, soak the Chinese medicine raw materials weighed in step S1 for 10-15 minutes, and then start to add water for decoction;

[0015] S3, filtering after decoction to obtain a filtrate, then heating and concentrating the filtrate to form a colloid with a relative density of 0.7-0.9, then adding 1-2 times the amount of 92% ethanol to fully stir, and refrigerating the stirred liquid for 25-29 hours;

[0016] S4, filtering the refrigerated solution to remove the precipitate, and then recovering the ethanol by distillation;

[0017] S5. Add food preservatives to the distilled liquid, and finally package the finished product and sterilize it by pasteurization to obtain a Chinese medicine composition.

[0018] Preferably, the Chinese medicine composition in step S5 is one of oral liquid, ointment or pills.

[0019] Preferably, the food preservative in step S5 is one of benzoic acid, potassium sorbate, sodium dehydroacetate or propyl paraben.

[0020] (III) Beneficial effects

[0021] The present invention provides a Chinese medicine composition for treating upper respiratory tract inflammation and a preparation method thereof. Compared with the prior art, the composition has the following beneficial effects:

[0022] (1) The Chinese medicine composition for treating upper respiratory tract inflammation and its preparation method, with burdock fruit as the main drug to dispel wind-heat, clear rash and relieve sore throat, detoxify and relieve swelling; with mulberry leaf, vitex rotundus and cicada shell as the assistant drugs to dispel wind-heat, clear lung and moisten dryness, clear liver and improve eyesight; with bupleurum, duckweed, fritillaria cirrhosa, bamboo shavings and kudzu root as the adjuvant drugs to clear surface and reduce fever, relieve liver and relieve depression, raise yang and lift sunken, induce sweat and relieve surface, clear rash and relieve itching, promote diuresis and reduce swelling, clear heat and resolve phlegm, moisten lung and relieve cough, dissipate nodules and reduce swelling; with honeysuckle, dandelion, inula flower etc. as the supporting drugs to dispel wind-heat, clear heat and detoxify, promote dampness and relieve stranguria, descend qi and resolve phlegm, descend adverse and stop vomiting, etc., the compatibility of the drugs is reasonable, and has the effects of dispersing wind-heat, clearing rash and relieving sore throat, detoxifying and dispersing swelling, relieving itching and promoting diuresis, descending qi and resolve phlegm, descend adverse and stop vomiting, etc., with good efficacy, short treatment course and no toxic side effects.

[0023] (2) The Chinese medicine composition for treating upper respiratory tract inflammation and its preparation method, through syndrome differentiation and treatment, rationally prepares Chinese medicine prescriptions, optimizes the combination mode, and the obtained prescription can more effectively treat sore throat and other upper respiratory tract inflammation. Through oral administration of Chinese medicine preparations, sore throat and other upper respiratory tract inflammation can be fundamentally treated, and the cure rate and recurrence rate can be significantly improved. Clinical verification: the total effective rate is 99% (cure rate 70%; effective rate 29%; ineffective rate 1%)). BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 The present invention is a flow chart of the preparation method. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0026] See also Figure 1 The present invention provides five technical solutions: a Chinese medicine composition for treating upper respiratory tract inflammation and a preparation method thereof, specifically including the following embodiments:

[0027] Embodiment 1: A Chinese medicine composition for treating upper respiratory tract inflammation comprises the following components by weight: 7g of burdock seeds, 7g of cicada shells, 7g of mulberry leaves, 7g of vitex rotundifolia, 7g of bupleurum, 7g of duckweed, 13g of fritillaria cirrhosa, 7g of bamboo shavings, 25g of kudzu root, 25g of honeysuckle, 30g of dandelion and 6g of inula flower, wherein the mulberry leaves have no worm holes on the surface and the leaves are glossy and rich.

[0028] The present invention also provides a method for preparing a Chinese medicine composition for treating upper respiratory tract inflammation, which specifically comprises the following steps:

[0029] S1. First, weigh the required weight portions of burdock seeds, cicada shells, mulberry leaves, vitex rotundifolia, bupleurum, duckweed, fritillaria cirrhosa, bamboo shavings, kudzu root, honeysuckle, dandelion and inula flower;

[0030] S2, soak the Chinese medicine raw materials weighed in step S1 for 13 minutes, and then start to add water for decoction;

[0031] S3, filtering after decoction to obtain a filtrate, then heating and concentrating the filtrate to form a colloid with a relative density of 0.8, then adding 1.5 times the amount of 92% ethanol to fully stir, and refrigerating the stirred liquid for 27 hours;

[0032] S4, filtering the refrigerated solution to remove the precipitate, and then recovering the ethanol by distillation;

[0033] S5. Add food preservatives to the distilled liquid, and finally package the finished product and sterilize it by pasteurization to obtain a Chinese medicine composition, which is an oral liquid and the food preservative is benzoic acid.

[0034] Embodiment 2: A Chinese medicine composition for treating upper respiratory tract inflammation comprises the following components by weight: 5g of burdock fruit, 5g of cicada shell, 5g of mulberry leaf, 5g of vitex rotundifolia, 5g of bupleurum, 5g of duckweed, 10g of fritillaria cirrhosa, 5g of bamboo shavings, 10g of kudzu root, 10g of honeysuckle, 10g of dandelion and 3g of inula flower, wherein the mulberry leaf has no worm holes on the surface and the leaves are glossy and rich.

[0035] The present invention also provides a method for preparing a Chinese medicine composition for treating upper respiratory tract inflammation, which specifically comprises the following steps:

[0036] S1. First, weigh the required weight portions of burdock seeds, cicada shells, mulberry leaves, vitex rotundifolia, bupleurum, duckweed, fritillaria cirrhosa, bamboo shavings, kudzu root, honeysuckle, dandelion and inula flower;

[0037] S2, soak the Chinese medicine raw materials weighed in step S1 for 10 minutes, and then start to add water for decoction;

[0038] S3, filtering after decoction to obtain a filtrate, then heating and concentrating the filtrate to form a colloid with a relative density of 0.7, then adding 1 times the amount of 92% ethanol to fully stir, and refrigerating the stirred liquid for 25 hours;

[0039] S4, filtering the refrigerated solution to remove the precipitate, and then recovering the ethanol by distillation;

[0040] S5. Adding a food preservative to the distilled liquid, finally packaging the finished product and sterilizing it by pasteurization to obtain a Chinese medicine composition, wherein the Chinese medicine composition is an ointment and the food preservative is potassium sorbate.

[0041] Example 3: A Chinese medicine composition for treating upper respiratory tract inflammation, comprising the following components by weight: 10g of burdock fruit, 10g of cicada shell, 10g of mulberry leaf, 10g of vitex rotundifolia, 10g of bupleurum, 10g of duckweed, 15g of fritillaria cirrhosa, 10g of bamboo shavings, 40g of kudzu root, 50g of honeysuckle, 50g of dandelion and 9g of inula flower, the mulberry leaf having no worm eyes on the surface and the leaves being shiny and rich.

[0042] The present invention also provides a method for preparing a Chinese medicine composition for treating upper respiratory tract inflammation, which specifically comprises the following steps:

[0043] S1. First, weigh the required weight portions of burdock seeds, cicada shells, mulberry leaves, vitex rotundifolia, bupleurum, duckweed, fritillaria cirrhosa, bamboo shavings, kudzu root, honeysuckle, dandelion and inula flower;

[0044] S2, soak the Chinese medicine raw materials weighed in step S1 for 15 minutes, and then start to add water for decoction;

[0045] S3, filtering after decoction to obtain a filtrate, then heating and concentrating the filtrate to form a colloid with a relative density of 0.9, then adding 2 times the amount of 92% ethanol to fully stir, and refrigerating the stirred liquid for 29 hours;

[0046] S4, filtering the refrigerated solution to remove the precipitate, and then recovering the ethanol by distillation;

[0047] S5. Add food preservatives to the distilled liquid, and finally package the finished product and sterilize it by pasteurization to obtain a Chinese medicine composition, which is a pill and the food preservative is sodium dehydroacetate.

[0048] Example 4: A Chinese medicine composition for treating upper respiratory tract inflammation, comprising the following components by weight: 6g of burdock seeds, 6g of cicada shells, 6g of mulberry leaves, 6g of vitex rotundifolia, 6g of bupleurum, 6g of duckweed, 11g of fritillaria cirrhosa, 6g of bamboo shavings, 11g of kudzu root, 11g of honeysuckle, 11g of dandelion and 4g of inula flower.

[0049] The present invention also provides a method for preparing a Chinese medicine composition for treating upper respiratory tract inflammation, which specifically comprises the following steps:

[0050] S1. First, weigh the required weight portions of burdock seeds, cicada shells, mulberry leaves, vitex rotundifolia, bupleurum, duckweed, fritillaria cirrhosa, bamboo shavings, kudzu root, honeysuckle, dandelion and inula flower;

[0051] S2, soak the Chinese medicine raw materials weighed in step S1 for 11 minutes, and then start to add water for decoction;

[0052] S3, filtering after decoction to obtain a filtrate, then heating and concentrating the filtrate to form a colloid with a relative density of 0.8, then adding 1.2 times the amount of 92% ethanol and stirring thoroughly, and refrigerating the stirred liquid at low temperature for 26 hours;

[0053] S4, filtering the refrigerated solution to remove the precipitate, and then recovering the ethanol by distillation;

[0054] S5. Add food preservatives to the distilled liquid, and finally package the finished product and sterilize it by pasteurization to obtain a Chinese medicine composition, which is an oral liquid and the food preservative is propylparaben.

[0055] Example 5: A Chinese medicine composition for treating upper respiratory tract inflammation, comprising the following components by weight: 9g of burdock seeds, 9g of cicada shells, 9g of mulberry leaves, 9g of vitex rotundifolia, 9g of bupleurum, 9g of duckweed, 14g of fritillaria cirrhosa, 9g of bamboo shavings, 39g of kudzu root, 49g of honeysuckle, 49g of dandelion and 8g of inula flower.

[0056] The present invention also provides a method for preparing a Chinese medicine composition for treating upper respiratory tract inflammation, which specifically comprises the following steps:

[0057] S1. First, weigh the required weight portions of burdock seeds, cicada shells, mulberry leaves, vitex rotundifolia, bupleurum, duckweed, fritillaria cirrhosa, bamboo shavings, kudzu root, honeysuckle, dandelion and inula flower;

[0058] S2, soak the Chinese medicine raw materials weighed in step S1 for 14 minutes, and then start to add water for decoction;

[0059] S3, filtering after decoction to obtain a filtrate, then heating and concentrating the filtrate to form a colloid with a relative density of 0.85, then adding 1.7 times the amount of 92% ethanol and stirring thoroughly, and refrigerating the stirred liquid at low temperature for 28 hours;

[0060] S4, filtering the refrigerated solution to remove the precipitate, and then recovering the ethanol by distillation;

[0061] S5. Add food preservatives to the distilled liquid, and finally package the finished product and sterilize it by pasteurization to obtain a Chinese medicine composition, wherein the Chinese medicine composition is an ointment and the food preservative is benzoic acid.

[0062] Usage: decoction in water, 1 dose / day, taken orally in two doses, after meals; 14 days as a course of treatment, 100 cases were clinically treated, 99 cases were effective, and only 1 case was not cured during follow-up after treatment. Oral Chinese medicine preparations are used to treat sore throat and other upper respiratory tract inflammations. They are derived from many years of medical practice. The concept and model of treating diseases and syndromes are different from those of Western medicine, with fewer side effects, so they have higher safety.

[0063] Application Examples

[0064] The Chinese medicine compositions for treating upper respiratory tract inflammation prepared by the preparation methods of Examples 1-5 of the present invention were respectively subjected to mouse animal experiments, and the existing conventional drugs for treating upper respiratory tract inflammation were selected as comparative examples. The mice were orally administered 1-3 ml at a time, 1-3 times a day, and the symptoms of the mice were observed once a week until a course of treatment (4 weeks) was taken and the following records were made. The specific experimental results are shown in the following table:

[0065]

[0066]

[0067] It can be seen from the above table that the effect of the Chinese medicine composition for treating upper respiratory tract inflammation prepared by Example 1 of the present invention is significantly better than that of Examples 2-5 and the comparative example, and the effect of the Chinese medicine composition for treating upper respiratory tract inflammation prepared by Examples 1-5 of the present invention is better than that of existing drugs.

[0068] Meanwhile, the contents not described in detail in this specification belong to the prior art known to those skilled in the art.

[0069] In summary, the present invention uses burdock seeds as the main drug to dispel wind-heat, clear rash and relieve sore throat, detoxify and relieve swelling; uses mulberry leaves, vitex rotundus, and cicada shells as the assistant drugs to dispel wind-heat, clear the lungs and moisten dryness, clear the liver and improve eyesight; uses bupleurum, duckweed, fritillaria cirrhosa, bamboo shavings, and kudzu root as the adjuvant drugs to clear the surface and reduce fever, soothe the liver and relieve depression, raise yang and lift the sunken, induce sweating and relieve the surface, clear rash and relieve itching, promote diuresis and reduce swelling, clear heat and resolve phlegm, moisten the lungs and relieve cough, and disperse nodules and reduce swelling; uses honeysuckle, dandelion, inula flower and the like as the guiding drugs to dispel wind-heat, clear heat and detoxify, promote dampness and relieve stranguria, and reduce The medicines are reasonably compatible, and have the effects of dispersing wind-heat, clearing rashes and relieving sore throat, detoxifying and relieving swelling, relieving itching and promoting urination, descending qi and resolving phlegm, descending adverse and stopping vomiting, etc. It has good efficacy, short course of treatment, and no toxic side effects. Through syndrome differentiation and treatment, reasonable preparation of Chinese medicine prescriptions, and optimized combination methods, the obtained prescriptions can more effectively treat sore throat and other upper respiratory tract inflammations. Through oral Chinese medicine preparations, sore throat and other upper respiratory tract inflammations can be fundamentally treated, significantly improving the cure rate and reducing the recurrence rate. Clinically verified: the total effective rate is 99% (cure rate 70%; effective rate 29%; ineffective rate 1%)).

[0070] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0071] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for treating upper respiratory tract inflammation, characterized in that: The invention comprises the following components by weight: 5-10g of burdock seeds, 5-10g of cicada shells, 5-10g of mulberry leaves, 5-10g of vitex rotundus, 5-10g of bupleurum, 5-10g of duckweed, 10-15g of fritillaria cirrhosa, 5-10g of bamboo shavings, 10-40g of kudzu root, 10-50g of honeysuckle, 10-50g of dandelion and 3-9g of inula flower.

2. A Chinese medicine composition for treating upper respiratory tract inflammation according to claim 1, characterized in that: The composition comprises the following components by weight: 7g of burdock seeds, 7g of cicada shells, 7g of mulberry leaves, 7g of vitex rotundifolia, 7g of bupleurum, 7g of duckweed, 13g of fritillaria cirrhosa, 7g of bamboo shavings, 25g of kudzu root, 25g of honeysuckle, 30g of dandelion and 6g of inula flower.

3. A Chinese medicine composition for treating upper respiratory tract inflammation according to claim 1, characterized in that: The composition comprises the following components by weight: 5g of burdock seeds, 5g of cicada shells, 5g of mulberry leaves, 5g of vitex rotundus, 5g of bupleurum, 5g of duckweed, 10g of fritillaria cirrhosa, 5g of bamboo shavings, 10g of kudzu root, 10g of honeysuckle, 10g of dandelion and 3g of inula flower.

4. A Chinese medicine composition for treating upper respiratory tract inflammation according to claim 1, characterized in that: The composition comprises the following components by weight: 10g of burdock seeds, 10g of cicada shells, 10g of mulberry leaves, 10g of vitex rotundus, 10g of bupleurum, 10g of duckweed, 15g of fritillaria cirrhosa, 10g of bamboo shavings, 40g of kudzu root, 50g of honeysuckle, 50g of dandelion and 9g of inula flower.

5. A Chinese medicine composition for treating upper respiratory tract inflammation according to any one of claims 1 to 4, characterized in that: The mulberry leaves have no insect holes on the surface and the leaves are glossy and full.

6. A method for preparing the Chinese medicine composition for treating upper respiratory tract inflammation according to any one of claims 1 to 4, characterized in that: The specific steps include: S1. First, weigh the required weight portions of burdock seeds, cicada shells, mulberry leaves, vitex rotundifolia, bupleurum, duckweed, fritillaria cirrhosa, bamboo shavings, kudzu root, honeysuckle, dandelion and inula flower; S2, soak the Chinese medicine raw materials weighed in step S1 for 10-15 minutes, and then start to add water for decoction; S3, filtering after decoction to obtain a filtrate, then heating and concentrating the filtrate to form a colloid with a relative density of 0.7-0.9, then adding 1-2 times the amount of 92% ethanol to fully stir, and refrigerating the stirred liquid for 25-29 hours; S4, filtering the refrigerated solution to remove the precipitate, and then recovering the ethanol by distillation; S5. Add food preservatives to the distilled liquid, and finally package the finished product and sterilize it by pasteurization to obtain a Chinese medicine composition.

7. A method for preparing a Chinese medicine composition for treating upper respiratory tract inflammation according to claim 6, characterized in that: In step S5, the Chinese medicine composition is one of oral liquid, paste or pills.

8. A Chinese medicine composition for treating upper respiratory tract inflammation and a preparation method thereof according to claim 1, characterized in that: The food preservative in step S5 is one of benzoic acid, potassium sorbate, sodium dehydroacetate or propyl paraben.

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