Traditional Chinese medicine formula for treating male infertility

Abstract

The invention relates to a traditional Chinese medicine formula for treating male infertility, which is composed of thirteen herbal medicines of male silkworm moth, pilose antler, epimedium, deer-horn glue, processed monkshood, agilawood, dendrobe, tortoise-plastron glue, cistanche, Chinese leek seed, semen cuscutae, cordyceps sinensis and hippocampus. The traditional Chinese medicine composition has the effects of clearing heat, eliminating dampness and tonifying spleen, and has a remarkable effect on treating the kidney-yang deficiency type infertility such as male oligospermia, male weakness, male death, malformation, azoospermia, non-liquefaction of seminal fluid, excessive seminal fluid volume, excessive seminal fluid volume, hematospermia, immune infertility and unknown reasons.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine formula for treating male infertility. Background Art

[0002] Male infertility is a global problem that affects family harmony and social stability. According to a survey by the World Health Organization, nearly 15% of couples of childbearing age have infertility problems, with 50% due to males and 50% due to females. The causes of male infertility are complex and the clinical manifestations are numerous. Currently, the main causal and symptomatic treatments include hormone therapy, surgical operations, nutritional therapy, and assisted reproductive technology. However, the efficacy still leaves much to be desired, such as low success rate, high cost, and a higher rate of birth defects in offspring than in naturally conceived children.

[0003] According to the literature, Chinese medicine's understanding of male infertility can be traced back to the Yellow Emperor's Classic of Internal Medicine, which had a relatively systematic discussion on male reproductive physiology and established a fertility concept centered on the kidney. The literature of all dynasties not only discussed its etiology and pathogenesis, but also accumulated rich experience in treatment. Wang Liguang studied and classified the medical records of Huang Haibo and other famous old Chinese medicine practitioners on male infertility and found that the most common syndromes were kidney essence deficiency, kidney yin deficiency, and kidney yang deficiency. Therefore, "kidney deficiency" is the main pathological basis of male infertility. Therefore, kidney tonification is an important method for the clinical treatment of male infertility. Modern studies have shown that kidney-tonifying Chinese medicine has a definite effect on the treatment of oligoasthenospermia, which can improve the physical and chemical indicators of patients' semen, with few adverse reactions and high safety. For example, Shengjingsan can improve the motility and quantity of rat sperm by upregulating the CatSper1 pathway, which is an effective means of treating oligoasthenospermia. Zhang Xiaohong et al.'s study showed that Jinkui Shenqi Pills can improve the sperm quality and sex hormone levels of rats with kidney yang deficiency model, and can inhibit testicular TGF-β1 Receptor expression, promote CYP19 expression and thus affect sperm development and proliferation; Wang Jiahui et al. used Yijing prescription to study the pharmacodynamics of adenine-treated rat model of kidney deficiency infertility and showed that Yishen prescription has obvious therapeutic effect.

[0004] Huang Haibo developed the "Huang's Sperm-Increasing Pills" and clinically observed 376 cases of male infertility, showing that 214 were cured, 103 were effective, and 59 were ineffective. "Huang's Sperm-Increasing Pills" was developed by Professor Huang Haibo in the early 1980s based on the theory of traditional Chinese medicine. He screened Chinese herbal medicines with the pharmacological effects of tonifying the kidney, strengthening yang and producing sperm. It is an effective prescription for treating male infertility. It has the functions of warming the kidney and producing sperm, and replenishing true fire. It is mainly composed of male silkworm moth, deer antler, epimedium, antler glue, cooked aconite, agarwood, dendrobium, tortoise shell glue, Cistanche deserticola, etc. "Huang's Sperm-Increasing Pills" was identified as the agreed prescription of the hospital where the project team is located. It has been promoted in the hospital since 1984. Up to now, it has been used for 37 years and has a definite effect on male infertility of kidney yang deficiency type. Such as few, weak, dead, deformed, azoospermia, semen liquefaction, too much, too little semen, hematospermia, immune infertility, unexplained infertility; At present, the clinical application of kidney-tonifying method involves diseases of various departments and systems. For some difficult and complicated diseases (such as male infertility), the treatment based on syndrome differentiation of traditional Chinese medicine and the treatment of kidney-tonifying method have achieved good results. Commonly used kidney-tonifying Chinese medicines in clinical practice include velvet antler, aconite, leek, Cistanche, Cuscuta, Epimedium, Cordyceps sinensis, seahorse, etc. Modern experimental research on kidney-tonifying Chinese medicine mainly focuses on the effects on sex hormone levels, the effects on apoptosis of spermatogenic cells, and the changes in gene expression profiles. It is believed that kidney-tonifying and spermatogenic prescriptions can regulate and improve reproductive function by regulating the disorders of the hypothalamus-pituitary-gonad axis, and have a multi-level and multi-target regulatory effect on the gonad axis, and a negative down-regulation effect on the induction and differentiation of spermatogenic stem cells and cell proliferation and division-related genes, and achieve the effect on gene expression profiles through multiple pathways.

[0005] Huang's Zengjing Pills are a traditional Chinese medicine compound preparation with multi-target pharmacological effects. At present, there is no comprehensive understanding of its overall pharmacodynamic mechanism. For this reason, we have introduced new ideas, methods and theories of modern pharmaceutical research, and studied the material basis of its pharmacological effects through effective research ideas and methods, determined the real material basis of pharmacological effects, and found and developed new medicinal resources and conducted in-depth research on its pharmacological activity and efficacy, and then developed and improved the basic research and modern theory of famous doctors' experience prescriptions; the traditional Chinese medicine prescription of the present invention, on the basis of retaining the real pharmacological substances, improves the prescription and selects Chinese herbal medicine prescriptions with the effects of tonifying the kidney, nourishing yin, producing essence, clearing away heat, removing dampness and strengthening the spleen, which is composed of thirteen herbs including male silkworm moth, velvet antler, epimedium, antler glue, roasted aconite, agarwood, dendrobium, tortoise shell glue, Cistanche, Allium, Cuscuta, Cordyceps and seahorse. In this Chinese medicine formula, the Yin-nourishing and kidney-tonifying drugs are combined with a small amount of epimedium and deer antler to warm the kidney and assist yang; and the kidney-tonifying and spermatogenic drugs are combined with blood-activating and blood-nourishing drugs, which have the effects of activating blood circulation, unblocking menstruation, and transforming blood into spermatogenesis. Summary of the invention

[0006] The object of the present invention is to provide a Chinese medicine formula for treating male infertility, which has the function of restoring testicular sperm production and has a definite therapeutic effect on infertility of kidney yang deficiency type due to unknown causes, such as few, weak, dead, deformed, azoospermia, non-liquefied semen, too much or too little semen, hematospermia, immune infertility, etc.

[0007] The objective of the present invention is achieved through the following technical solutions: A Chinese medicine formula for treating male infertility, the Chinese medicine formula comprising thirteen kinds of herbs: male silkworm moth, pilose antler, epimedium, antler glue, roasted aconite root, agarwood, dendrobium, tortoise shell glue, Cistanche deserticola, leek seed, dodder seed, cordyceps sinensis, and seahorse; The weight ratio of the Chinese medicine formula is: 10-12 parts of male silkworm moth, 5-10 parts of pilose antler, 5-10 parts of epimedium, 10-15 parts of antler glue, 12-20 parts of roasted aconite, 12-20 parts of agarwood, 15-25 parts of dendrobium, 12-18 parts of tortoise shell glue, 10-15 parts of Cistanche, 20-30 parts of allium seeds, 10-15 parts of dodder seeds, 5-10 parts of cordyceps, and 5-10 parts of seahorse; The traditional Chinese medicine prescription is prepared from 10 parts of male silkworm moth, 8 parts of pilose antler, 6 parts of epimedium, 12 parts of antler glue, 13 parts of roasted aconite root, 15 parts of agarwood, 20 parts of dendrobium, 14 parts of tortoise shell glue, 12 parts of cistanche, 25 parts of leek seeds, 10 parts of dodder seeds, 5 parts of cordyceps and 5 parts of seahorse.

[0008] The beneficial effects of the present invention are: 1. The Chinese medicine prescription of the present invention is composed of 13 kinds of herbs, including male silkworm moth, pilose antler, epimedium, antler glue, roasted aconite, agarwood, dendrobium, tortoise shell glue, Cistanche deserticola, Allium leek, Cuscuta australis, Cordyceps sinensis and seahorse. It has the effects of warming the kidney and producing sperm, replenishing true fire, and can better improve the physical and chemical indicators of semen of patients, and has few adverse reactions and high safety. The clinical observation results of 376 cases of male infertility showed that 214 cases were cured, 103 cases were effective, and 59 cases were ineffective; 2. It has been promoted in the hospital since 1984 and has been used for 37 years. It has a definite effect on kidney yang deficiency type infertility such as oligospermia, weakness, death, deformity, azoospermia, semen liquefaction, excessive semen volume, too little semen, hematospermia, immune infertility, and unexplained causes. 3. Clinical applications involve diseases of various departments and systems. For some difficult and complicated diseases (such as male infertility), we use TCM syndrome differentiation and treatment, combined with kidney-tonifying methods, with good results. DETAILED DESCRIPTION

[0009] The present invention will be further described in detail below in conjunction with examples, but the implementation mode of the present invention is not limited thereto, and the protection scope of the present invention cannot be limited by the following examples; the experimental methods used in the following implementation examples are all conventional methods unless otherwise specified; the materials, reagents, etc. used, unless otherwise specified, can all be obtained from commercial channels.

[0010] Example 1 The weight ratio of the Chinese medicine prescription of the present invention is: 10 parts of male silkworm moth, 5 parts of pilose antler, 5 parts of epimedium, 10 parts of antler glue, 12 parts of roasted aconite, 12 parts of agarwood, 15 parts of dendrobium, 12 parts of tortoise shell glue, 10 parts of Cistanche, 20 parts of allium seeds, 10 parts of dodder seeds, 5 parts of cordyceps and 5 parts of seahorse.

[0011] Example 2 The weight ratio of the Chinese medicine prescription of the present invention is: 12 parts of male silkworm moth, 10 parts of pilose antler, 10 parts of epimedium, 15 parts of antler glue, 20 parts of roasted aconite, 20 parts of agarwood, 25 parts of dendrobium, 18 parts of tortoise shell glue, 15 parts of Cistanche, 30 parts of allium seeds, 15 parts of dodder seeds, 10 parts of cordyceps and 10 parts of seahorse.

[0012] Example 3 The traditional Chinese medicine prescription of the invention comprises the following weight proportions: 10 parts of male silkworm moth, 8 parts of pilose antler, 6 parts of epimedium, 12 parts of antler glue, 13 parts of roasted aconite root, 15 parts of agarwood, 20 parts of dendrobium, 14 parts of tortoise shell glue, 12 parts of cistanche, 25 parts of leek seeds, 10 parts of dodder seeds, 5 parts of cordyceps and 5 parts of seahorse.

Claims

1. A Chinese medicine for treating male infertility, characterized in that: The Chinese medicine formula consists of 13 kinds of herbs, including male silkworm moth, pilose antler, epimedium, antler glue, roasted aconite root, agarwood, dendrobium, tortoise shell glue, cistanche, leek seed, dodder seed, cordyceps sinensis and seahorse.

2. The Chinese medicine for treating male infertility according to claim 1, characterized in that: The weight ratio of the traditional Chinese medicine is: 10-12 parts of male silkworm moth, 5-10 parts of pilose antler, 5-10 parts of epimedium, 10-15 parts of antler glue, 12-20 parts of roasted aconite, 12-20 parts of agarwood, 15-25 parts of dendrobium, 12-18 parts of tortoise shell glue, 10-15 parts of cistanche, 20-30 parts of leek seeds, 10-15 parts of dodder seeds, 5-10 parts of cordyceps and 5-10 parts of seahorse.

3. The Chinese medicine for treating male infertility according to claim 2, characterized in that: The traditional Chinese medicine comprises 10 parts of male silkworm moth, 8 parts of pilose antler, 6 parts of epimedium, 12 parts of antler glue, 13 parts of roasted aconite, 15 parts of agarwood, 20 parts of dendrobium, 14 parts of tortoise shell glue, 12 parts of cistanche, 25 parts of leek seeds, 10 parts of dodder seeds, 5 parts of cordyceps and 5 parts of seahorse.