Clinical medicinal solid reagent dissolving device

Abstract

The invention provides a clinical medicinal solid reagent dissolving device, and belongs to the technical field of medicinal solid reagent dissolving. Comprising a fixing seat, a first fixing frame and a second fixing frame are fixedly connected to the outer portion of the fixing seat, a grinding cabin is assembled in the second fixing frame, second electric telescopic rods are symmetrically installed at the top end of the first fixing frame, and first electric telescopic rods are symmetrically installed at the bottom end of the first fixing frame. By arranging the flow limiting assembly, a solid reagent crushed in the powder grinding cabin is not put into the dissolving tank at a time to be dissolved, but is gradually added into the dissolving tank, so that the reagent entering the dissolving tank can be fully contacted with a solution in the dissolving tank to be dissolved; compared with a mode of dissolving in a dissolving tank at one time, the dissolving efficiency is higher, and the working efficiency of the device is further improved.

Description

Technical Field

[0001] The invention relates to the technical field of dissolving medicinal solid reagents, and in particular to a clinical medicinal solid reagent dissolving device. Background Art

[0002] When conducting clinical pharmaceutical experiments, solid reagents need to be dissolved. In the specific operation, the solid reagents and solutions are mostly poured into a container, and then the operator holds the container and shakes it or uses a glass rod to stir and dissolve it, finally achieving the dissolution of the solid reagent. The solid reagent dissolving device for clinical pharmacy is a device specially designed for the field of clinical pharmacy. It is used to dissolve solid reagents efficiently and accurately to meet the needs of drug development, formulation preparation, clinical trials and other processes.

[0003] Existing dissolution devices generally achieve automatic dissolution of solid reagents by setting up a grinding mechanism and a stirring mechanism, that is, the solid reagent to be dissolved is ground and crushed by a grinding mechanism, and the crushed solid reagent is then mixed with a solution, and stirred and mixed by a stirring mechanism, so as to improve the dissolution efficiency of the solid reagent. However, since the ground solid reagent is added to the solution at one time, it is easy to cause the particles of the reagent to adhere to each other, thereby reducing the effective surface area in contact with the solvent, and ultimately affecting the dissolution rate. Secondly, in the process of crushing the solid reagent by the grinding mechanism, it is inevitable that powder and particle reagent residues will appear on the outside, which will then cause the dissolved amount of the reagent to be lower than the weighing value, affecting the final experimental data. Therefore, the present application provides a clinical pharmaceutical solid reagent dissolution device to meet the needs. Summary of the invention

[0004] The technical problem to be solved by the present invention is to provide a clinical pharmaceutical solid reagent dissolving device to solve the problem that the existing dissolving device has low dissolving efficiency and is prone to produce crushed solid reagent residues in the device.

[0005] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0006] A clinical pharmaceutical solid reagent dissolving device comprises a fixing seat, wherein the outside of the fixing seat is fixedly connected with a first fixing frame and a second fixing frame, wherein a grinding chamber is assembled in the second fixing frame, wherein a second electric telescopic rod is symmetrically installed at the top of the first fixing frame, wherein a first electric telescopic rod is symmetrically installed at the bottom of the first fixing frame, wherein a mounting frame is fixedly connected at the end of the second electric telescopic rod, wherein a tray is fixedly connected at the end of the first electric telescopic rod, wherein a dissolving tank is placed on the tray, wherein a first connecting rod is sleeved in the grinding chamber, wherein a closing cover is fixedly connected at the bottom of the mounting frame, wherein a servo motor is arranged at the top of the closing cover; a connecting assembly for associating the servo motor with the first connecting rod, wherein the connecting assembly is respectively connected with a driving shaft of the servo motor and the first connecting rod; a current limiting assembly for limiting the discharge speed of the solid reagent after being crushed in the grinding chamber, wherein the current limiting assembly is respectively connected with the grinding chamber and the first connecting rod; and a vibration assembly for generating vibration in the grinding chamber to discharge the residual reagent, wherein the vibration assembly is connected with the inner side wall of the grinding chamber.

[0007] Optionally, a guide rod corresponding to the movable range of the mounting frame and the tray is provided on the fixed seat, and the mounting frame and the tray are movably mounted on the outside of the guide rod. A controller is fixedly connected to the outside of the fixed seat, and the controller is electrically connected to the first electric telescopic rod, the second electric telescopic rod and the servo motor.

[0008] Optionally, one end of the first connecting rod is located inside the grinding chamber, and the other end of the first connecting rod extends to the outside of the grinding chamber and is fixedly connected to evenly distributed stirring rods, and the first connecting rod is fixedly connected to a crushing column and a crushing disk outside the area where the first connecting rod is located in the grinding chamber.

[0009] Optionally, the tray is provided with a storage groove adapted to the bottom shape of the dissolving tank, and a first annular guard plate surrounding the outside of the storage groove is fixedly connected to the tray, and evenly distributed reinforcing ribs are provided between the outer wall of the first annular guard plate and the tray.

[0010] Optionally, the connecting assembly includes a second connecting rod fixedly connected to the outside of the driving shaft of the servo motor and a transmission sleeve fixedly connected to the end of the first connecting rod, the end of the second connecting rod is fixedly connected to a transmission head, and the transmission sleeve is provided with a docking groove that matches the shape of the transmission head.

[0011] Optionally, the transmission sleeve is located at an end of the first connecting rod away from the stirring rod, the second connecting rod and the closing cover are movably connected via a bearing, and an inclined surface is provided at the entrance of the docking groove.

[0012] Optionally, the flow limiting assembly includes a flow limiting sleeve fixedly connected to the outside of the first connecting rod and a second through opening opened at the bottom end of the grinding chamber, the bottom of the grinding chamber is an inverted frustum, the second through openings are evenly distributed at the bottom of the grinding chamber, and the flow limiting sleeve is provided with evenly distributed first through openings.

[0013] Optionally, the upper part of the flow limiting sleeve is provided with a second annular guard plate adapted to the shape of the bottom of the grinding chamber, and the lower part of the flow limiting sleeve is provided with a focusing chamber, the first through opening is provided in the middle area of ​​the flow limiting sleeve, and the shape of the first through opening is adapted to the shape of the second through opening.

[0014] Optionally, the vibration assembly includes a vibration frame fixedly connected to the inner wall of the grinding chamber and evenly distributed, a filling chamber is provided at the connecting end between the vibration frame and the inner wall of the grinding chamber, the bottom of the filling chamber is provided with an inclined surface facing the inner wall of the grinding chamber, and a feeding hole is provided at the bottom of the filling chamber.

[0015] Optionally, a vibrating end facing the central axis of the grinding chamber is fixedly connected to the outside of the vibrating frame, a groove matching the end shape of the vibrating end is provided on the outside of the transmission head, and a wavy deformation zone is provided between the vibrating end and the vibrating frame.

[0016] Compared with the prior art, the present invention has at least the following beneficial effects:

[0017] In the above scheme, by setting a current limiting component, the solid reagent that has been crushed in the grinding chamber is not put into the dissolution tank for dissolution at one time, but is gradually added into the dissolution tank, so that the reagent entering the dissolution tank can fully contact and dissolve with the solution in the dissolution tank. Compared with the method of putting it into the dissolution tank for dissolution at one time, the dissolution efficiency is higher, which further improves the working efficiency of the device.

[0018] By setting up a connecting component and a current limiting component, after the connecting component connects the first connecting rod, it can drive the rotation of the first connecting rod to drive other structures associated with the first connecting rod to work synchronously, and then the current limiting component and the stirring rod, crushing column and crushing disk on the first connecting rod can work synchronously, so that the crushing of solid reagents in the grinding chamber, the stirring in the dissolving tank, and the gradual discharge of the crushed reagents in the grinding chamber can be carried out synchronously. The structures cooperate with each other and complement each other to jointly realize the technical solution of the entire device.

[0019] By setting the vibration end and deformation zone in the vibration assembly, after the solid reagent is crushed and gradually discharged and stirred and dissolved in the grinding chamber, the closing cover can drive the transmission head to move to a position corresponding to the vibration end, and then the transmission head rotates to hit the vibration end, causing the vibration end to deform in the deformation zone, and drive the entire vibration assembly and the grinding chamber to generate high-frequency vibration, discharge the residual reagent powder particles on the structure of the grinding chamber, and ensure the accuracy of the experimental data.

[0020] By setting the vibration frame, the injection chamber and the deformation zone in the vibration assembly, positioning is provided for the operation of adding solid reagents into the grinding chamber, ensuring the falling trajectory of the solid reagents after entering the grinding chamber, ensuring that the solid reagents can be in the working area of ​​the crushing column and the crushing disk after entering the grinding chamber, avoiding the solid reagents from falling into the docking groove and causing the residues to be unable to be removed, ensuring the normal operation of the connecting assembly, and further avoiding the generation of solid reagent residues, thereby ensuring the working quality of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The accompanying drawings, which are incorporated herein and constitute a part of the specification, illustrate embodiments of the invention and, together with the description, further serve to explain the principles of the invention and to enable those skilled in the relevant art to make and use the invention.

[0022] Figure 1 It is a schematic diagram of the three-dimensional structure of the first state of the clinical pharmaceutical solid reagent dissolving device;

[0023] Figure 2 It is a schematic diagram of the three-dimensional structure of the second state of the clinical pharmaceutical solid reagent dissolving device;

[0024] Figure 3 It is a schematic diagram of the three-dimensional structure of the dissolving tank and the tray;

[0025] Figure 4 It is a schematic diagram of the matching structure of the closing cover and the second connecting rod;

[0026] Figure 5 This is a schematic diagram of the inner structure of the grinding cabin;

[0027] Figure 6 is a schematic diagram of the three-dimensional structure of the first connecting rod;

[0028] Figure 7 It is a schematic diagram of the partial cross-sectional structure of the current limiting sleeve;

[0029] Figure 8 This is a schematic diagram of the cross-sectional structure of the grinding cabin;

[0030] Fig. 9 for Figure 8 The enlarged structural diagram at A in the middle;

[0031] Fig.10for Figure 8 The enlarged structural diagram at B in the middle;

[0032] Fig.11 It is a schematic diagram of the matching structure of the transmission head and the vibration frame;

[0033] Fig.12 This is a schematic diagram of the three-dimensional structure of the vibration frame.

[0034] Reference numerals:

[0035] 1. Fixed seat; 2. First fixed frame; 3. Second fixed frame; 4. Mounting frame; 5. First electric telescopic rod; 6. Second electric telescopic rod; 7. Grinding chamber; 8. Closing cover; 9. Servo motor; 10. Current limiting sleeve; 11. First connecting rod; 12. Stirring rod; 13. Dissolving tank; 14. Tray; 15. Controller; 16. Storage slot; 17. First annular guard plate; 18. Second connecting rod; 19. Transmission head; 20. Transmission sleeve; 21. Docking slot; 22. Vibration frame; 23. Filling chamber; 24. Vibration end; 25. Crushing column; 26. Crushing disk; 27. Second annular guard plate; 28. Central chamber; 29. ​​First through opening; 30. Second through opening; 31. Groove; 32. Deformation zone; 33. Feed hole.

[0036] As shown in the figure, in order to clearly implement the structure of the embodiment of the present invention, specific structures and devices are marked in the figure, but this is only for illustrative purposes and is not intended to limit the present invention to the specific structure, device and environment. According to specific needs, ordinary technicians in this field can adjust or modify these devices and environments. DETAILED DESCRIPTION

[0037] The following is a detailed description of a clinical pharmaceutical solid reagent dissolving device provided by the present invention in conjunction with the accompanying drawings and specific embodiments. At the same time, it is explained here that in order to make the embodiments more detailed, the following embodiments are the best and preferred embodiments, and those skilled in the art may also adopt other alternatives to implement some known technologies; and the accompanying drawings are only for a more specific description of the embodiments, and are not intended to specifically limit the present invention.

[0038] It should be noted that the references to "one embodiment", "embodiment", "exemplary embodiments", "some embodiments" and the like in the specification indicate that the embodiments described may include specific features, structures or characteristics, but not every embodiment may include the specific features, structures or characteristics. In addition, when a specific feature, structure or characteristic is described in conjunction with an embodiment, it should be within the knowledge of a person skilled in the art to implement such feature, structure or characteristic in conjunction with other embodiments (whether or not explicitly described).

[0039] In general, a term can be understood, at least in part, from its use in context. For example, depending, at least in part, on the context, the term "one or more" as used herein can be used to describe any feature, structure, or characteristic in the singular sense, or can be used to describe a combination of features, structures, or characteristics in the plural sense. Additionally, the term "based on" can be understood as not necessarily intended to convey an exclusive set of factors, but can instead, depending, at least in part, on the context, allow for the presence of other factors that are not necessarily explicitly described.

[0040] It will be understood that the meanings of “on,” “over,” and “above” in the present invention should be interpreted in the broadest manner, so that “on” not only means “directly on” something, but also includes the meaning of being “on” something with intervening features or layers therebetween, and “on” or “over” not only means “on” or “above” something, but also includes the meaning of being “on” or “above” something with no intervening features or layers therebetween.

[0041] Additionally, spatially relative terms such as "under," "beneath," "lower," "above," "upper," and the like may be used herein for descriptive convenience to describe the relationship of one element or feature to another element or features, as shown in the accompanying drawings. Spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the accompanying drawings. The device may be oriented in other ways, and the spatially relative descriptors used herein may be similarly interpreted accordingly.

[0042] like Figures 1 to 12As shown, an embodiment of the present invention provides a clinical pharmaceutical solid reagent dissolving device, comprising a fixed base 1, a fixed base 1, a first fixed frame 2 and a second fixed frame 3 are fixedly connected to the outside of the fixed base 1, a grinding chamber 7 is assembled in the second fixed frame 3, a second electric telescopic rod 6 is symmetrically installed at the top of the first fixed frame 2, a first electric telescopic rod 5 is symmetrically installed at the bottom of the first fixed frame 2, the end of the second electric telescopic rod 6 is fixedly connected to a mounting frame 4, a tray 14 is fixedly connected to the end of the first electric telescopic rod 5, a dissolving tank 13 is placed on the tray 14, a first connecting rod 11 is sleeved in the grinding chamber 7, a closing cover 8 is fixedly connected to the bottom of the mounting frame 4, a servo motor 9 is arranged on the top of the closing cover 8, and the setting of the first fixed frame 2 provides an installation position for the first electric telescopic rod 5 and the second electric telescopic rod 6 outside the fixed base 1, which is for the first electric telescopic rod 5 and the second electric telescopic rod 6 to be installed at the outside of the fixed base 1. An electric telescopic rod 5 and a second electric telescopic rod 6 provide a stable working environment, and the second fixing frame 3 is used to fix the grinding chamber 7 to keep the grinding chamber 7 fixed in the external position of the fixing seat 1. When the second electric telescopic rod 6 is working, it can drive the mounting frame 4 and the closing cover 8 to rise and fall, and then realize the opening and closing of the top of the grinding chamber 7 through the closing cover 8, so that the structure in the grinding chamber 7 can keep the grinding chamber 7 in a closed state during the working process of crushing the solid reagent. The first connecting rod 11 can rotate in the grinding chamber 7, and drive various structures in the device to perform corresponding work during the rotation process to ensure that various structures in the device can operate synchronously, and cooperate to complete the crushing of the solid reagent, the gradual discharge of the crushed solid reagent and the stirring and mixing of the discharged powdered and granular reagent in the dissolving tank 13, so that the entire device can completely complete the dissolution operation of the solid reagent.

[0043] A connecting component is used to associate the servo motor 9 with the first connecting rod 11. The connecting components are respectively connected to the driving shaft of the servo motor 9 and the first connecting rod 11. The connecting component remains connected when the closing cover 8 is closed. At this time, the driving shaft of the servo motor 9 is associated with the first connecting rod 11 through the connecting component. When the servo motor 9 is working, it can drive the first connecting rod 11 to rotate through the driving shaft, and then all other structures related to the first connecting rod 11 are in working state, so as to realize the dissolution operation of the device on the solid reagent; a current limiting component is used to limit the discharge speed of the crushed solid reagent in the grinding chamber 7. The current limiting components are respectively connected to the grinding chamber 7 and the first connecting rod 11. The current limiting component works following the rotation of the first connecting rod 11 to discharge the crushed solid reagent stored in the grinding chamber 7. The reagent is gradually released, thereby controlling the amount of reagent entering the dissolution tank 13, so as to avoid mutual adhesion between the reagent particles, increase the effective surface area of ​​the reagent and the solvent, and accelerate the dissolution speed; the vibration component is used to generate vibration in the grinding chamber 7 to discharge the residual reagent. The vibration component is connected to the inner wall of the grinding chamber 7. The setting of the vibration component enables the device to open the closing cover 8 after completing the crushing and gradual discharge of the solid reagent, so that the structure in the connecting component corresponds to the position of the vibration component, and then through the operation of the servo motor 9, the connecting component triggers the vibration component to work, generating high-frequency vibration in the grinding chamber 7, and shaking off the solid reagent of the powder particle device remaining in the grinding chamber 7, ensuring that all the solid reagents in the grinding chamber 7 are discharged into the dissolution tank 13 for dissolution.

[0044] In this embodiment, if Figures 1 to 6As shown, the fixing seat 1 is provided with a guide rod corresponding to the movable range of the mounting frame 4 and the tray 14, and the mounting frame 4 and the tray 14 are both movably sleeved on the outside of the guide rod. A controller 15 is fixedly connected to the outside of the fixing seat 1, and the controller 15 is electrically connected to the first electric telescopic rod 5, the second electric telescopic rod 6 and the servo motor 9. The controller 15 is used to control the working state of the first electric telescopic rod 5, the second electric telescopic rod 6 and the closing cover 8 in the device, so that they can form a match, so that the device as a whole can work in different states and different electrical equipment. The principle and use process of the controller 15 are the same as those in the prior art, and no more details are given here. When the device as a whole is in the first state, the closing cover 8 remains open under the action of the second electric telescopic rod 6, and the tray 14 remains in contact with the bottom of the inner wall of the fixing seat 1 under the action of the first electric telescopic rod 5. The open state of the closing cover 8 exposes the opening at the top of the grinding chamber 7, which is convenient for the experimenter to add solid reagent raw materials into the grinding chamber 7, and the position of the tray 14 allows enough space between the tray 14 and the stirring rod 12 to facilitate The experimenter places the dissolving tank 13 containing the solvent on the tray 14. Under the control of the controller 15, the device as a whole can be switched from the first state to the second state. When the device as a whole is in the second state, the first electric telescopic rod 5 and the second electric telescopic rod 6 are both in a retracted state, and the closing cover 8 closes the top of the grinding chamber 7. The dissolving tank 13 rises with the tray 14 and is sleeved on the outside of the stirring rod 12. The solvent in the dissolving tank 13 submerges the stirring rod 12, and the solid reagent is ready to be crushed and dissolved. One end of the first connecting rod 11 is located inside the grinding chamber 7. , and the other end of the first connecting rod 11 extends to the outside of the grinding chamber 7 and is fixedly connected to a uniformly distributed stirring rod 12, and the first connecting rod 11 is located in the grinding chamber 7. The area outside is fixedly connected to a crushing column 25 and a crushing disk 26. When the device as a whole is in the second state, through the connection of the connecting components, the servo motor 9 can drive the crushing column 25 and the crushing disk 26 on the first connecting rod 11 to rotate when working, and hit and crush the solid reagent, so that the solid reagent can be discharged from the grinding chamber 7 in the form of powder particles, which is convenient for subsequent dissolution operations.

[0045] In this embodiment, if Figures 1 to 3As shown, the tray 14 is provided with a storage groove 16 that is compatible with the bottom shape of the dissolving tank 13, and the tray 14 is fixedly connected with a first annular guard plate 17 that surrounds the outside of the storage groove 16, and evenly distributed reinforcing ribs are arranged between the outer wall of the first annular guard plate 17 and the tray 14. The arrangement of the tray 14 is to provide a stable working environment for the dissolving tank 13. After the dissolving tank 13 is placed on the tray 14, the bottom of the dissolving tank 13 is sleeved in the storage groove 16 on the tray 14, and the first annular guard plate 17 surrounds the outside of the dissolving tank 13, and the structural strength of the first annular guard plate 17 is strengthened by the reinforcing ribs, further ensuring the stability of the dissolving tank 13 after it is placed on the tray 14. The lifting and lowering of the tray 14 can drive the dissolving tank 13 to produce corresponding displacement, and by changing the space size between the tray 14 and the stirring rod 12, sufficient space is provided for taking and placing the dissolving tank 13, so as to facilitate the placement of the dissolving tank 13 before dissolving the solid reagent and the taking operation after the reagent is dissolved.

[0046] In this embodiment, if Figures 4 to 9 As shown, the connecting assembly includes a second connecting rod 18 fixedly connected to the outside of the driving shaft of the servo motor 9 and a transmission sleeve 20 fixedly connected to the end of the first connecting rod 11. The end of the second connecting rod 18 is fixedly connected to a transmission head 19. A docking groove 21 adapted to the shape of the transmission head 19 is opened in the transmission sleeve 20. The transmission sleeve 20 is located at the end of the first connecting rod 11 away from the stirring rod 12. The second connecting rod 18 is movably connected to the closing cover 8 through a bearing. An inclined surface is provided at the entrance of the docking groove 21. The bearing between the second connecting rod 18 and the closing cover 8 ensures the rotational activity of the second connecting rod 18 under the closing cover 8. When the device as a whole is in the second state, the transmission head 19 and the transmission sleeve 20 in the connecting assembly are docked with each other, so that the second connecting rod 18 and the first connecting rod 11 are in an associated connection state. The inclined surface at the entrance of the docking groove 21 increases the surface area at the entrance of the docking groove 21. The area at the entrance of the docking groove 21 is larger than the end surface area of ​​the transmission head 19, which facilitates the insertion of the transmission head 19 into the docking groove 21 and facilitates the connection between the transmission head 19 and the transmission sleeve 20. After the servo motor 9 works and drives the second connecting rod 18 to rotate through its driving shaft, it can drive the first connecting rod 11 to rotate through the transmission of the transmission head 19 and the transmission sleeve 20 to work, so that the stirring rod 12, the crushing column 25 and the crushing disk 26 on the first connecting rod 11 are all rotated. The rotation of the crushing column 25 and the crushing disk 26 can crush the solid reagent in the grinding chamber 7, and the reagent discharged after crushing enters the dissolving tank 13 and contacts with the solution and dissolves. The rotation of the stirring rod 12 driven by the first connecting rod 11 can also stir the solution in the dissolving tank 13, further increasing the contact area between the solution and the crushed reagent, and further accelerating the dissolution rate of the solid reagent.

[0047] In this embodiment, if Figures 5 to 10 As shown, the flow limiting assembly includes a flow limiting sleeve 10 fixedly connected to the outside of the first connecting rod 11 and a second through opening 30 opened at the bottom end of the grinding chamber 7. The bottom of the grinding chamber 7 is in an inverted truncated cone shape. The second through openings 30 are evenly distributed at the bottom of the grinding chamber 7. The flow limiting sleeve 10 is provided with evenly distributed first through openings 29. The upper half of the flow limiting sleeve 10 is provided with a second annular guard plate 27 adapted to the shape of the bottom of the grinding chamber 7, and the lower half of the flow limiting sleeve 10 is provided with a focusing chamber 28. The first through opening 29 is provided in the middle area of ​​the flow limiting sleeve 10, and the second through opening 29 is provided in the middle area of ​​the flow limiting sleeve 10. The shape of the first through opening 29 is adapted to the shape of the second through opening 30. The second annular guard plate 27 of the upper part of the flow limiting sleeve 10 is sleeved on the outside of the bottom end of the grinding chamber 7 to strengthen the sealing effect of the flow limiting sleeve 10 on the bottom end of the grinding chamber 7. The setting of the concentration chamber 28 forms a shield for the solid reagent powder at the bottom of the flow limiting sleeve 10, so that the powder can be more concentratedly put into the dissolving tank 13 after being discharged through the flow limiting sleeve 10. When the device is in the second state as a whole, the rotation of the first connecting rod 11 will not only drive the crushing column 25 and the crushing disk 26 to carry out solid reagent in the grinding chamber 7. In addition to the crushing, the limiting sleeve 10 can also be driven to rotate. Since the limiting sleeve 10 is provided with uniformly distributed first through openings 29, and the bottom of the grinding chamber 7 is provided with a second through opening 30, the rotation of the limiting sleeve 10 will cause the first through openings 29 and the second through openings 30 to correspond to each other alternately, and then the bottom of the grinding chamber 7 and the limiting sleeve 10 will be intermittently in an open state due to the rotation of the first connecting rod 11, so that the solid reagent that has been crushed in the grinding chamber 7 and has a particle size smaller than the opening size of the first through opening 29 and the second through opening 30 can be opened. It can be discharged gradually instead of being poured into the dissolution tank 13 all at once after being crushed, so that the crushed solid reagent can gradually contact with the solution in the dissolution tank 13, and the reagents entering the dissolution tank 13 can fully contact with the solution in the dissolution tank 13, and a small amount of reagent is gradually added, and the solute concentration in the solution gradually increases, avoiding the problem of excessive local concentration, avoiding the enhanced interaction between solute molecules due to excessive local concentration, and inhibiting the dissolution process, and cooperating with the stirring rod 12 in the dissolution tank 13 to allow the solid reagent to quickly complete the dissolution process.

[0048] In this embodiment, if Figure 11 to Figure 12As shown, the vibration assembly includes a vibration frame 22 fixedly connected to the inner wall of the grinding chamber 7 and evenly distributed, and a filling chamber 23 is provided at the connection end between the vibration frame 22 and the inner wall of the grinding chamber 7. The bottom of the filling chamber 23 is provided with an inclined surface facing the inner wall of the grinding chamber 7, and a feed hole 33 is provided at the bottom of the filling chamber 23. The opening of the filling chamber 23 can provide positioning for the experimenter when putting solid reagents into the grinding chamber 7. The solid reagents put in from the filling chamber 23 leak into the grinding chamber 7 through the feed hole 33, providing guidance and limitation for the entry of the solid reagents, and preventing the solid reagents from entering the docking on the transmission sleeve 20. In the groove 21, the outside of the vibration frame 22 is fixedly connected with a vibration end 24 facing the central axis of the grinding chamber 7, and the outside of the transmission head 19 is provided with a groove 31 adapted to the end shape of the vibration end 24. A wave-shaped deformation zone 32 is arranged between the vibration end 24 and the vibration frame 22. The arrangement of the deformation zone 32 makes the thickness of the vibration end 24 at the deformation zone 32 smaller than the thickness of other areas on the vibration frame 22 and the vibration end 24, and the strength is smaller. Then, after the vibration end 24 is hit during the rotation of the transmission head 19, it can be deformed more easily at the deformation zone 32, and the entire vibration The movable frame 22 and the grinding chamber 7 generate corresponding vibrations. When the reagent stored in the grinding chamber 7 is crushed and gradually discharged into the dissolving tank 13, the dissolving tank 13 maintains the position of being sleeved on the outside of the stirring rod 12, and the first electric telescopic rod 5 drives the mounting frame 4 and the closing cover 8 to move, so that the position of the closing cover 8 corresponds to the position of the first state of the device as a whole, and the first through opening 29 on the limiting sleeve 10 remains corresponding to the second through opening 30 at the bottom of the grinding chamber 7, so that the bottom end of the grinding chamber 7 is kept in the open state. At this time, the transmission head 19 at the end of the second connecting rod 18 and the vibration end 24 on the vibration frame 22 are in contact with each other. The ends of the vibration end 24 are connected to each other, and the end of the vibration end 24 is embedded in the groove 31 on the transmission head 19. In this way, when the servo motor 9 continues to work and drives the transmission head 19 to rotate through the second connecting rod 18, the vibration end 24 will be moved to generate bending deformation in the deformation zone 32, and then the transmission head 19 hits the vibration end 24, so that the vibration frame 22 and the grinding chamber 7 as a whole generate corresponding high-frequency vibration, and the residual solid reagent in the grinding chamber 7 is shaken down, so that the solid reagent to be dissolved can completely enter the dissolution tank 13 for dissolution, effectively reducing the residual reagent in the device and ensuring the accuracy of the experimental data.

[0049] The present invention covers any substitution, modification, equivalent method and scheme made on the essence and scope of the present invention. In order to make the public have a thorough understanding of the present invention, specific details are described in detail in the following preferred embodiments of the present invention, but those skilled in the art can fully understand the present invention without the description of these details. In addition, in order to avoid unnecessary confusion about the essence of the present invention, well-known methods, processes, procedures, components and circuits are not described in detail.

[0050] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A clinical pharmaceutical solid reagent dissolving device, characterized in that: The invention comprises a fixing seat, the outside of which is fixedly connected with a first fixing frame and a second fixing frame, a grinding chamber is installed in the second fixing frame, a second electric telescopic rod is symmetrically installed at the top of the first fixing frame, a first electric telescopic rod is symmetrically installed at the bottom of the first fixing frame, a mounting frame is fixedly connected to the end of the second electric telescopic rod, a tray is fixedly connected to the end of the first electric telescopic rod, a dissolving tank is placed on the tray, a first connecting rod is sleeved in the grinding chamber, a closing cover is fixedly connected to the bottom of the mounting frame, and a servo motor is arranged on the top of the closing cover; A connecting assembly, used to associate the servo motor with the first connecting rod, the connecting assembly being connected to the driving shaft of the servo motor and the first connecting rod respectively; A flow limiting component, used for limiting the discharge speed of the crushed solid reagent in the grinding chamber, wherein the flow limiting component is respectively connected to the grinding chamber and the first connecting rod; The vibration component is used to generate vibration in the grinding chamber to discharge the residual reagent, and the vibration component is connected to the inner side wall of the grinding chamber.

2. The clinical pharmaceutical solid reagent dissolving device according to claim 1, characterized in that: The fixing seat is provided with a guide rod corresponding to the movable range of the mounting frame and the tray. The mounting frame and the tray are movably mounted on the outside of the guide rod. A controller is fixedly connected to the outside of the fixing seat. The controller is electrically connected to the first electric telescopic rod, the second electric telescopic rod and the servo motor.

3. The clinical pharmaceutical solid reagent dissolving device according to claim 2, characterized in that: One end of the first connecting rod is located inside the grinding chamber, and the other end of the first connecting rod extends to the outside of the grinding chamber and is fixedly connected to evenly distributed stirring rods, and the first connecting rod is fixedly connected to a crushing column and a crushing disk outside the area where the first connecting rod is located in the grinding chamber.

4. The clinical pharmaceutical solid reagent dissolving device according to claim 3, characterized in that: The tray is provided with a storage groove matched with the bottom shape of the dissolving tank, and the tray is fixedly connected with a first annular guard plate surrounding the outside of the storage groove, and evenly distributed reinforcing ribs are arranged between the outer wall of the first annular guard plate and the tray.

5. The clinical pharmaceutical solid reagent dissolving device according to claim 4, characterized in that: The connecting assembly includes a second connecting rod fixedly connected to the outside of the driving shaft of the servo motor and a transmission sleeve fixedly connected to the end of the first connecting rod. The end of the second connecting rod is fixedly connected to a transmission head, and the transmission sleeve is provided with a docking groove that matches the shape of the transmission head.

6. The clinical pharmaceutical solid reagent dissolving device according to claim 5, characterized in that: The transmission sleeve is located at one end of the first connecting rod away from the stirring rod, the second connecting rod and the closing cover are movably connected via a bearing, and an inclined surface is arranged at the entrance of the docking groove.

7. The clinical pharmaceutical solid reagent dissolving device according to claim 6, characterized in that: The flow limiting assembly includes a flow limiting sleeve fixedly connected to the outside of the first connecting rod and a second through opening opened at the bottom end of the grinding chamber, the bottom of the grinding chamber is in an inverted frustum shape, the second through openings are evenly distributed at the bottom of the grinding chamber, and the flow limiting sleeve is provided with evenly distributed first through openings.

8. The clinical pharmaceutical solid reagent dissolving device according to claim 7, characterized in that: The upper part of the flow limiting sleeve is provided with a second annular guard plate adapted to the shape of the bottom of the grinding chamber, and the lower part of the flow limiting sleeve is provided with a focusing chamber, the first through opening is provided in the middle area of ​​the flow limiting sleeve, and the shape of the first through opening is adapted to the shape of the second through opening.

9. The clinical pharmaceutical solid reagent dissolving device according to claim 5, characterized in that: The vibration assembly includes a vibration frame fixedly connected to the inner wall of the grinding chamber and evenly distributed, a filling chamber is provided at the connection end between the vibration frame and the inner wall of the grinding chamber, the bottom of the filling chamber is provided with an inclined surface facing the inner wall of the grinding chamber, and a feeding hole is provided at the bottom of the filling chamber.

10. The clinical pharmaceutical solid reagent dissolving device according to claim 9, characterized in that: The outside of the vibration frame is fixedly connected with a vibration end facing the central axis of the grinding chamber, the outside of the transmission head is provided with a groove matched with the end shape of the vibration end, and a wavy deformation zone is provided between the vibration end and the vibration frame.

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