Compound traditional Chinese medicine antipruritic preparation and preparation method thereof

Abstract

The invention provides a compound traditional Chinese medicine antipruritic preparation and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The spray is prepared by compounding traditional Chinese medicinal materials such as rhizoma atractylodis, mint, radix angelicae, clove, herba eupatorii, herba asari, rhizoma zingiberis, folium mori, cortex mori radicis, cacumen biotae, macleaya cordata, pericarpium zanthoxyli and shikimic herb in proportion after alcohol extraction and acid extraction, and menthol, borneol, glycerol and rose essential oil are supplemented. The preparation method comprises the processes of medicinal material crushing, alcohol dipping extraction, vinegar dipping extraction, vacuum concentration, low-temperature centrifugation, microporous membrane filtration and reverse dilution. The finished product has multiple effects of resisting inflammation, sterilizing, relieving itching and moisturizing, and can quickly relieve itching caused by eczema, dermatitis, psoriasis and the like, and the average onset time is 3 seconds. In addition, the spray is convenient to use, safe, non-irritant, free of hormones, not prone to causing drug resistance and suitable for long-term use.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine preparations, and more particularly to a composite Chinese medicine antipruritic preparation and a preparation method thereof. Background Art

[0002] The active ingredients of traditional antipruritic agents are mostly capsaicin, anesthetics, calcineurin inhibitors, glucocorticoids, cannabinoids, doxepin, prostate inhibitors, etc.

[0003] Capsaicin exerts its antipruritic effect by acting on TRPV1 and consuming substance P. It can be used to treat localized pruritus, especially neurogenic pruritus such as paresthesia back pain, brachioradialis pruritus and postherpetic neuralgia. It can also be used for nodular prurigo, aquagenic pruritus, psoriasis and uremic pruritus.

[0004] Topical local anesthetics such as 1% pramoxine cream, 2.5% to 5% lidocaine and 2.5% prilocaine compound cream can be used to treat neurogenic pruritus and facial or anogenital pruritus. The main adverse reactions are local numbness and occasional skin allergies.

[0005] Topical calcineurin inhibitors include tacrolimus and pimecrolimus, which can produce indirect antipruritic effects by regulating T cell activation and inhibiting the release of inflammatory cytokines, and can also exert direct antipruritic effects through TRPV1. Calcineurin inhibitors can reduce the pruritus symptoms of inflammatory skin diseases such as eczema, anogenital pruritus, lichen sclerosus, lichen planus, and prurigo nodularis. Calcineurin inhibitors do not cause skin atrophy and can be used on the face, genitals, and intertriginous areas. Common side effects are transient burning sensations that occur within a few days after the start of medication, which may be caused by TRPV1 activation and usually subside after repeated use for several days. Some people believe that the burning sensation can be used as a biological marker for the onset of antipruritic effects.

[0006] In clinical practice, topical glucocorticoids are often used to treat pruritus. In fact, the hormone itself has no direct antipruritic effect. It indirectly controls pruritus by inhibiting the action of cytokines and reducing local inflammation. It is also effective for secondary manifestations of chronic pruritus, such as nodular inflammation and chronic simple lichen. The side effects of topical glucocorticoids include local atrophy, pigment changes, capillary dilation, and systemic absorption risks. Large-area, long-term use should be avoided. In addition, hormones can also show rapid tolerance, that is, the efficacy is reduced after repeated topical use.

[0007] Some studies have demonstrated the efficacy of cannabinoids in reducing pruritus. In an open-label trial of 3000 patients with atopic dermatitis, N-palmitoylethanolamine cream significantly reduced pruritus and disease severity. In addition, cannabinoids are effective for lichen simplex chronicus, prurigo nodularis, and uremic pruritus with minimal side effects.

[0008] Doxepin is a tricyclic antidepressant with both anti-H1 and anti-H2 properties. The topical dosage form is a 5% cream, which can be used for short-term treatment of atopic dermatitis, simple lichen chronicus, nummular eczema and contact dermatitis. This product can be absorbed systemically and cause drowsiness, and can also cause allergic contact dermatitis, so large-area (≤5% body surface area) and long-term use (≤7 days) should be avoided. It is contraindicated for children, pregnant women and lactating women, and should be used with caution by the elderly.

[0009] Prostaglandin inhibitors, aspirin and salicylates, exert their antipruritic effect by inhibiting the itch-enhancing factor prostaglandin E2 and can be used for chronic simple lichen planus. A common side effect is a transient burning sensation.

[0010] The above drug components take effect slowly and are not suitable for long-term use. They are easy to cause drug resistance in the body. For some patients with severe eczema, psoriasis, and dermatitis, the symptoms are prone to relapse after drug withdrawal. Therefore, it is a technical problem to be solved in the field to provide a pure composite Chinese medicine antipruritic preparation that can quickly relieve itching, thoroughly prevent and treat eczema, psoriasis, dermatitis, repair damaged skin, and prevent insects and sterilize. Summary of the invention

[0011] In order to solve the above problems, the purpose of the present invention is to provide a composite Chinese medicine antipruritic preparation, which is a Chinese medicine alcohol extract and a Chinese medicine acid extract compounded in an appropriate proportion, containing 13 kinds of Chinese medicines including Atractylodes lancea, mint, Angelica dahurica, clove, Perilla frutescens, Asarum, dried ginger, mulberry leaf, Morus alba bark, Platycladus orientalis, Macleaya cordata, Sichuan pepper, and Mangcao, supplemented with menthol and borneol cooling agents, and glycerin as a moisturizer, which can reduce P substance in the primary afferent skin sensory nerve endings, relieve skin itching and other chronic paresthesias. The Chinese medicine in the prescription has multiple functions such as antipruritic and wind-dispelling, insecticidal, detoxifying, anti-inflammatory, and moisturizing, and has a strong therapeutic effect on itchy diseases such as eczema, psoriasis, and dermatitis; menthol and borneol external use can make the skin feel cold. Reduce the degree of itching caused by histamine and effectively relieve local itching.

[0012] To achieve the above object, the present invention provides the following technical solutions, which mainly include: A composite Chinese medicine antipruritic preparation, comprising the following raw material components and their weight fractions: Among them, the Chinese medicinal ingredients are as follows: 20-30 parts by weight of atractylodes, 20-30 parts of mint, 10-20 parts of angelica, 10-20 parts of cloves, 10-20 parts of perilla, 5-10 parts of asarum, 5-10 parts of dried ginger, 10-20 parts of mulberry leaves, 10-20 parts of mulberry bark, 10-20 parts of oriental arborvitae leaves, 5-10 parts of macleaya, 5-10 parts of Sichuan pepper, 5-10 parts of mangosteen, 10-15 parts of phellodendron, and 5-10 parts of liquorice; Matrix and auxiliary materials: 1200-1500 parts of 75% alcohol, 350-400 parts of glycerin as a moisturizer, 300-400 parts of vinegar, 10-15 parts of menthol as a coolant, 1-1.5 parts of borneol, 0.1-0.2 parts of rose essential oil as a flavoring agent, and 5-10 parts of seaweed extract.

[0013] Preferably, the active ingredients of Atractylodes lancea are atractylodesin, 2-carene, atractylodes lactone, patchouliene, elemene, acetylatractyl alcohol, and dehydrocostus ester.

[0014] The preparation method of the composite Chinese medicine antipruritic preparation comprises the following steps: Step 1: Grind Atractylodes lancea, mint, angelica dahurica, clove, Perilla frutescens, Asarum, dried ginger, mulberry leaf, Morus alba bark, Platycladus orientalis leaf, Boletus chinensis, Sichuan pepper, and Mangcao into 40-60 mesh coarse powder respectively; Step 2: Weigh the coarse powders of Atractylodes lancea, mint, Angelica dahurica, clove, Perilla frutescens, Asarum sieboldii, and dried ginger according to the composition ratio, mix them evenly, and place them in a glass container; add 75% alcohol in an amount of 8-10 times the weight of the powders for immersion to obtain an alcohol filtrate; Step 3: vacuum concentrate the alcohol filtrate obtained in step 2 until the concentrate is equivalent to the initial amount of drug powder, and the distilled alcohol is reserved; the alcohol concentrate is centrifuged at high speed and the supernatant is taken as the alcohol filtrate for later use; Step 4: adding 1%-2% of menthol and 1‰-1.5‰ of borneol to the distillate in step 3 to prepare an alcohol solution of menthol and borneol; Step 5: Weigh mulberry leaves, white mulberry bark, arborvitae leaves, Machelianthes, Sichuan pepper, and Mangcao coarse powder according to the group distribution ratio, mix them evenly, and place them in a glass container; add 3.5 degree vinegar with a weight of 3-6 times of the powder weight to soak; obtain vinegar filtrate; Step 6: vacuum concentrate the vinegar filtrate obtained in step 5 until the concentrate is equivalent to the initial amount of drug powder, and obtain the vinegar distillate for use; centrifuge the vinegar concentrate at high speed to obtain the supernatant as the vinegar filtrate for use; Step 7: Combine the alcohol and vinegar filtrates of step 3 and step 6, mix menthol and borneol with chitosan by spray drying to prepare microcapsules, and add the microcapsules to the alcohol solution; dilute the menthol and borneol alcohol solution at a volume ratio of 1:4-5 to obtain an antipruritic spray stock solution; Step 8: Evenly mix the antipruritic spray stock solution in step 7 with the vinegar distillate and glycerin in step 6 in a volume ratio of 3:1:1, and add 0.1‰-0.2‰ of rose essential oil and seaweed extract to the mixed solution to obtain an antipruritic spray.

[0015] Preferably, in step 2, 75% alcohol in an amount of 8-10 times the weight of the medicinal powder is added for soaking, the alcohol liquid level covers the medicinal materials, and the mixture is stirred evenly and fully mixed, and then ultrasonic treatment is performed with a power of 200 W and a treatment time of 20 minutes to improve the extraction efficiency of the active ingredients; the soaking time is 48-72 hours, and intermittent stirring technology is used, with stirring for 10 minutes every 6 hours.

[0016] Preferably, in step three, the alcohol concentrate is centrifuged at 8500 r / min for 10 min in a high-speed centrifuge, the supernatant is taken, and the precipitate is discarded; the supernatant is filtered with a 0.45 um organic microporous filter membrane to remove macromolecular substances, and the alcohol filtrate is taken for later use.

[0017] Preferably, in step five, 3.5 degree vinegar is added in an amount of 3-6 times the weight of the powder for soaking; after stirring evenly and fully mixing, ultrasonic treatment is combined with a power of 200 W and a treatment time of 20 minutes to improve the extraction efficiency of the active ingredient; the soaking time is 48-72 hours, and intermittent stirring technology is used, stirring for 10 minutes every 6 hours.

[0018] Preferably, in step six, the concentrate is centrifuged at 8500 r / min for 10 min in a high-speed centrifuge, the supernatant is taken, and the precipitate is discarded; the supernatant is filtered with a 0.45 um water-based microporous filter membrane to remove macromolecular substances, and the vinegar filtrate is taken for later use.

[0019] Preferably, the method further comprises adding 75% alcohol in an amount of 8-10 times the weight of the medicinal powder for immersion in step 2, wherein the alcohol liquid level covers the medicinal material, stirring evenly to allow the medicinal material to fully contact with the solvent, sealing and allowing to stand to prevent the alcohol from volatilizing; the immersion time is 48-72 hours, and stirring regularly for 3-5 times; In step 3, the alcohol concentrate is centrifuged at 8500 r / min for 10 min in a high-speed centrifuge, the supernatant is taken, and the precipitate is discarded; the supernatant is filtered with a 0.45 um organic microporous filter membrane to remove macromolecular substances, and the alcohol filtrate is taken for use; In step 5, add 3.5 degree vinegar of 3-6 times the weight of the powder for soaking; stir evenly to make the medicinal material fully contact with the solvent, seal and let stand to prevent water from volatilizing; soak for 48-72 hours, and stir regularly 3-5 times; In step six, the concentrate is centrifuged at 8500 r / min for 10 min in a high-speed centrifuge, the supernatant is taken, and the precipitate is discarded; the supernatant is filtered with a 0.45 um water-based microporous filter membrane to remove macromolecular substances, and the vinegar filtrate is taken for later use.

[0020] It can be seen from the above technical scheme that, compared with the prior art, the present invention provides a composite Chinese medicine antipruritic preparation and a preparation method thereof. In the preparation method, low-temperature cold extraction, low-temperature centrifugation, microporous membrane filtration and reverse dilution methods are adopted to obtain a composite Chinese medicine antipruritic preparation with a relatively small molecular weight and easily absorbed and utilized by the skin, which not only reduces the resistance during spraying, but also can quickly atomize the liquid medicine to increase the contact area with the skin. The volatile components in menthol and borneol can increase the transdermal effect of other Chinese medicine effective components, thereby ensuring the functional effects of the composite Chinese medicine antipruritic preparation. The preparation process of the product is simple, rose essential oil can refresh the brain and cover up the smell of Chinese medicine, does not require too much manpower and material resources, and is suitable for mass production. The composite Chinese medicine antipruritic preparation prepared according to the above technical scheme has the following advantages: (l) The finished product is clear and translucent, and immediately produces a cool and comfortable feeling when sprayed on the skin; (2) The solvent used is 75% medical alcohol, which not only has a bactericidal and disinfecting effect, but also does not stain or contaminate clothing; (3) The medicinal materials and matrix used in the antipruritic spray have the effect of treating skin diseases. Chinese medicine accounts for 100%, and the content of effective ingredients such as Atractylodes macrocephala, Angelica dahurica, and Mentha arvense reaches 15%-20%. The drug release and transdermal properties are strong, which improves the efficacy and shortens the treatment period by 1 / 2-3 / 4 compared with ordinary antipruritic sprays. (4) The finished product is easy to use and carry, and the drug can quickly come into contact with the skin and take effect; (5) It reduces skin irritation and allergic reactions, and is especially suitable for patients with a history of allergies to hormonal drugs. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] The antipruritic spray of the present invention is prepared by compounding a Chinese medicine alcohol extract and a Chinese medicine acid extract in an appropriate proportion, and contains 13 kinds of Chinese medicines including atractylodes, mint, angelica dahurica, clove, perilla, asarum, dried ginger, mulberry leaf, mulberry bark, arborvitae leaf, macauliflower, pepper, and mangosteen, supplemented with menthol and borneol cooling agents, and glycerin as a moisturizer, which can reduce substance P in the primary afferent skin sensory nerve endings, relieve skin itching and other chronic paresthesias. The Chinese medicine in the prescription has multiple functions such as antipruritic and wind-dispelling, insecticidal, detoxifying, anti-inflammatory, and moisturizing, and has a strong therapeutic effect on itchy diseases such as eczema, psoriasis, and dermatitis; external use of menthol and borneol can make the skin feel cold. Reduce the degree of itching caused by histamine and effectively relieve local itching.

[0023] The antipruritic spray prepared by the present invention has a good antipruritic effect on the subjects and can quickly relieve the itching (average onset time 3s). In addition, in addition to the antipruritic effect, the present invention has a significant repair effect on skin lesions caused by eczema, psoriasis, athlete's foot, etc., and the effective rates for localized skin itching and neurodermatitis are 98% and 96.9% respectively. The effective rate of skin lesion regression is more than 94%.

[0024] For most subjects, the itching symptoms completely disappeared within 1-3 days of taking the medicine, and the adverse stimulation such as local scratching was reduced accordingly. The erythema and papules completely disappeared within 3-5 days. It has the advantages of being safe, free of side effects, easy to absorb, quick in effect, not prone to recurrence, and not causing dependence on the drug. It has good therapeutic effects on a variety of skin diseases with itching symptoms, and has anti-inflammatory, bactericidal, and mosquito repellent effects.

[0025] In addition, the present invention also provides a method for preparing a pure composite Chinese medicine antipruritic preparation. The method is simple and easy to implement and adopts alcohol extraction and concentration, acid extraction and concentration reverse dilution processes.

[0026] In order to solve the above technical problems, the present invention provides a pure composite Chinese medicine antipruritic preparation, comprising the following raw materials: Chinese medicinal ingredients: 20-30 parts of Atractylodes lancea, 20-30 parts of mint, 10-20 parts of Angelica dahurica, 10-20 parts of cloves, 10-20 parts of Perilla frutescens, 5-10 parts of Asarum, 5-10 parts of dried ginger, 10-20 parts of mulberry leaves, 10-20 parts of Morus alba bark, 10-20 parts of Platycladus orientalis leaves, 5-10 parts of Machees, 5-10 parts of Sichuan pepper, 5-10 parts of Mangcao, 10-15 parts of Phellodendron amurense, and 5-10 parts of Licorice; Matrix and auxiliary materials: 1200-1500 parts of 75% alcohol, 350-400 parts of glycerin as a moisturizer, 300-400 parts of vinegar, 10-15 parts of menthol as a coolant, 1-1.5 parts of borneol, 0.1-0.2 parts of rose essential oil as a flavoring agent, and 5-10 parts of seaweed extract.

[0027] The Atractylodes lancea used in the present invention contains ingredients such as atractylodesin, 2-carene, atractylodes lactone, patchouliene, elemene, acetylatractyl alcohol, dehydrocostus ester, etc., which has the effects of drying dampness and strengthening the spleen, dispelling wind and dispersing cold, and is a dampness-removing medicine. It has significant effects on beriberi and rheumatic pain. Mint is light and dispersing, and has the functions of dispersing wind-heat, dispelling toxins and clearing rashes, and dispelling wind and relieving itching. It has a significant effect on measles that does not clear up and urticaria itching. Angelica dahurica has the effects of dispelling cold, dispelling wind and relieving pain, clearing the nasal passages, drying dampness and stopping leukorrhea, reducing swelling and draining pus, dispelling wind and relieving itching. It can be used for sores, carbuncles, swellings, rheumatic itching of the skin, contact dermatitis and other eczema, carbuncle and furuncle. Clove and Perilla can clear away heat and dampness, and remove turbidity with fragrance. Especially for mosquito bites in summer, rub them out of water and apply them to the bitten area to stop the itching caused by mosquito bites. It also has significant effects on skin heat toxins and damage caused by eczema, psoriasis, and dermatitis; Asarum and dried ginger have the effects of dispersing wind and relieving itching, and are effective for a variety of skin diseases, especially itching caused by wind evil; they can also be used to treat damp-heat, blood deficiency and wind-dryness. Angelica dahurica and Asarum are used together. Both are pungent, warm and fragrant, and can dispel wind and relieve exterior symptoms, dispel cold and relieve pain, and clear the nasal passages. The three Chinese medicines also have the effects of aromatic dispersion, opening the orifices and refreshing the mind, which helps to relieve the patient's mood caused by skin itching.

[0028] Mulberry leaves and mulberry bark can dispel wind, clear heat and detoxify, and have obvious effects on sores, carbuncles and swellings.

[0029] The leaves of Platycladus orientalis are astringent, cool blood and stop bleeding. They can relieve heat bleeding caused by itching and scratching, and can also detoxify. They are an important medicine for treating burns and ulcers.

[0030] Bo Luo Hui tastes bitter and pungent, and is cold and warm in nature. It is mainly used to treat painful sores, carbuncles, ecthyma, hemorrhoids, eczema and snake and insect bites.

[0031] Sichuan pepper has a miraculous effect on lacquer sores. Mangcao has the functions of dispelling wind and reducing swelling. It is mainly used to treat headaches, carbuncle, skin paralysis, scrofula, breast carbuncle, throat paralysis, hernia, scabies, baldness, etc.

[0032] Phellodendron amurense enhances antibacterial and anti-inflammatory effects and is particularly useful for skin conditions such as eczema.

[0033] Licorice has the effect of relieving skin irritation and anti-allergic, increasing its safety.

[0034] Added seaweed extract as a skin repairer to promote the regeneration of damaged skin.

[0035] The antipruritic spray of the present invention uses 75% alcohol as the matrix, which has good transdermal effect after spraying, can promote skin absorption, quickly relieve symptoms, and accelerate tissue cell regeneration. Vinegar is rich in acetic acid, citric acid, malic acid, succinic acid and other organic acids, which mainly accelerates the renewal of keratin, helps to peel off melanin in the skin, shrink pores, dissolve blackheads, repair damaged skin, etc., and can make the skin soft and comfortable, and the complexion fresh and pure.

[0036] The spray also contains an appropriate amount of menthol and borneol, which has a fresh aroma, a spicy and cool taste, and has the effects of antibacterial and anti-inflammatory, refreshing the mind, clearing heat and relieving pain, clearing heat and purging fire, detoxifying and reducing swelling, drying dampness and astringing sores, and relieving itching. In addition, the fragrance and coolness of borneol also increase the comfort of patients during spraying. Rose essential oil can not only improve the smell of traditional Chinese medicine in the spray, but also improve dry skin, restore skin elasticity, and repair damaged skin.

[0037] The pure compound Chinese medicine antipruritic preparation prepared with the above raw materials combines the efficacy of each raw material, and combines different raw materials according to the compatibility principle to achieve synergistic and superimposed effects on different skin itching diseases. It has a wide range of anti-inflammatory and antibacterial effects, and has significant effects on skin diseases such as acne, allergic dermatitis, various tinea, etc.; at the same time, it has a good effect on symptoms such as redness, swelling, heat and pain caused by skin burns, snake and insect bites, and trauma, and can accelerate skin recovery and regeneration. It has the advantages of safety, no side effects, quick effect, and short course of treatment. Since the spray is a pure Chinese medicine external preparation, there is no need to strictly control the dosage of the medicine, which avoids the drug resistance and superinfection caused by antibiotic external medicines and Chinese and Western composite external medicines that must be strictly used according to the dosage.

[0038] The present invention also provides a method for preparing a pure composite Chinese medicine antipruritic preparation, comprising the following steps: Step 1: Use a grinder to grind Atractylodes lancea, mint, angelica dahurica, clove, Perilla frutescens, Asarum, dried ginger, mulberry leaf, white mulberry bark, Platycladus orientalis leaf, Macheia recutita, Sichuan pepper, and Mangcao into 40-60 mesh coarse powder respectively; if the grinding particle size is too fine, the powder is easily wrapped into a mass by the solvent during extraction, and it is not easy to dissolve the effective ingredients; if the grinding particle size is too coarse, the contact area between the medicinal materials and the extractant is small, and it is not easy to dissolve the effective ingredients to the maximum extent; Step 2: Weigh the coarse powders of Atractylodes lancea, mint, angelica dahurica, clove, perilla, asarum, and dried ginger according to the above ratio and mix them evenly, and place them in a glass container. Add 75% alcohol 8-10 times the weight of the powder for soaking. Make sure that the alcohol liquid level covers the medicinal materials, stir evenly, and after sufficient mixing, combine with ultrasonic treatment with a power of 200W and a treatment time of 20 minutes to improve the extraction efficiency of the active ingredients; the soaking time is 48-72h, and the intermittent stirring technology is used, stirring for 10 minutes every 6 hours. The experiment shows that if the soaking time is too short, the active ingredients cannot be fully dissolved. When the soaking time reaches about 72h, the dissolution rate of the active ingredients basically does not change; after the soaking is completed, filter to obtain the alcohol filtrate.

[0039] Step 3: Vacuum concentrate the obtained alcohol filtrate until the concentrate is equivalent to the initial amount of drug powder, and the distilled alcohol is reserved. The concentrate is centrifuged at 8500r / min for 10 minutes in a high-speed centrifuge, and the supernatant is taken and the precipitate is discarded. The supernatant is filtered with a 0.45um organic microporous filter membrane to remove macromolecular substances, and the filtrate is reserved. After sufficient mixing, it is combined with ultrasonic treatment with a power of 200W and a treatment time of 20 minutes to improve the extraction efficiency of the active ingredients; the immersion time is 48-72h, and the intermittent stirring technology is used, and stirring is carried out for 10 minutes every 6 hours.

[0040] Step 4: adding 1%-2% of menthol and 1‰-1.5‰ of borneol to the distillate in step 3 to prepare an alcohol solution of menthol and borneol; Step 5: Weigh mulberry leaves, white mulberry bark, arborvitae leaves, macaulifolia, Sichuan pepper, and mangosteen coarse powder according to the above ratio and mix them evenly, and place them in a glass container. Add 3.5 degree vinegar 3-6 times the weight of the powder for soaking. Stir evenly to make the medicinal materials fully contact with the solvent, and after fully mixing, combine with ultrasonic treatment with a power of 200W and a treatment time of 20 minutes to improve the extraction efficiency of the effective ingredients; the soaking time is 48-72h, and the intermittent stirring technology is used, stirring for 10 minutes every 6 hours. The test shows that if the soaking time is too short, the effective ingredients cannot be fully dissolved. When the soaking time reaches about 72h, the dissolution rate of the effective ingredients basically does not change; after the soaking is completed, filter to obtain the vinegar filtrate.

[0041] Step 6: The obtained vinegar filtrate is vacuum concentrated until the concentrate is equivalent to the initial amount of drug powder, and the white vinegar distillate is obtained for use. The concentrate is centrifuged at 8500r / min in a high-speed centrifuge for 10 minutes, the supernatant is taken, and the precipitate is discarded. The supernatant is filtered with a 0.45um water-based microporous filter membrane to remove macromolecular substances, and the filtrate is taken for use.

[0042] Step 7: Combine the alcohol and vinegar filtrates of step 3 and step 6, mix menthol and borneol with chitosan by spray drying to prepare microcapsules, and add the microcapsules to the alcohol solution; dilute the menthol and borneol alcohol solution at a volume ratio of 1:4-5 to obtain an antipruritic spray stock solution; Step 8: Evenly mix the antipruritic spray stock solution in step 7 with the vinegar distillate and glycerin in step 6 in a volume ratio of 3:1:1, and add 0.1‰-0.2‰ of rose essential oil and seaweed extract to the mixed solution to obtain an antipruritic spray.

[0043] In order to verify the therapeutic effect of the composite Chinese medicine antipruritic preparation described in the above embodiment, the antipruritic spray of the present invention was respectively used on 312 patients with different skin diseases, and the efficacy was followed up and observed. The method of use was: external spray, 2-3 times a day, 7 days as a course of treatment, the therapeutic effect is shown in Table-1, and the others in Table-1 include mosquito bites, skin itching, etc. Table-1 Observation table of efficacy follow-up in patients with skin itching Patient's condition Number of cases Number of cures Number of effective cases Invalid cases Cure rate Efficiency Itchy skin 59 57 1 1 96.61% 98% Seborrheic dermatitis 62 61 1 0 98.39% 100% Allergic dermatitis 48 48 0 0 100.00% 100.00% Neurodermatitis 32 30 1 1 93.75% 96.88% Psoriasis 18 17 0 1 94.44% 94% beriberi 26 25 1 0 96.15% 100.00% Tinea pedis 15 14 1 0 93.33% 100% other 27 25 1 1 92.59% 96.30% total 287 277 6 4 96.52% 98.61% Typical examples: Case 1: A 29-year-old woman suffered from eczema on her neck with obvious itching. She sprayed the composite Chinese medicine antipruritic preparation of the present invention and the itching stopped in 1 day, and was cured in 3 days. Her skin was fully repaired in 7 days without recurrence, and her skin was obviously delicate and smoother after the cure than before.

[0044] Case 2: A 35-year-old female had psoriasis on both legs for three years with severe itching and pain. After spraying the composite Chinese medicine antipruritic preparation of the present invention, the itching and pain disappeared in 3 days, the effect was seen in 7 days, and the patient was cured in 14 days without recurrence.

[0045] Case 3: A female, 18 years old, had allergic dermatitis and severe itching symptoms. After spraying the composite Chinese medicine antipruritic preparation of the present invention, the itching disappeared in 1 day, and the skin returned to normal in 3 days without recurrence.

[0046] Case 4: A 32-year-old male had athlete's foot on both feet for 5 years with repeated recurrences. After spraying the composite Chinese medicine antipruritic preparation of the present invention, the itching stopped in 1 day, the skin was repaired in 3 days, and the condition was cured in 7 days without recurrence.

[0047] In this specification, each embodiment is described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the embodiments can be referred to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part.

[0048] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A composite Chinese medicine antipruritic preparation, characterized in that: It includes the following raw material components and their mass fractions: Among them, the Chinese medicinal ingredients are as follows: 20-30 parts by weight of atractylodes, 20-30 parts of mint, 10-20 parts of angelica, 10-20 parts of cloves, 10-20 parts of perilla, 5-10 parts of asarum, 5-10 parts of dried ginger, 10-20 parts of mulberry leaves, 10-20 parts of mulberry bark, 10-20 parts of oriental arborvitae leaves, 5-10 parts of macleaya, 5-10 parts of Sichuan pepper, 5-10 parts of mangosteen, 10-15 parts of phellodendron, and 5-10 parts of liquorice; Matrix and auxiliary materials: 1200-1500 parts of 75% alcohol, 350-400 parts of glycerin as a moisturizer, 300-400 parts of vinegar, 10-15 parts of menthol as a coolant, 1-1.5 parts of borneol, 0.1-0.2 parts of rose essential oil as a flavoring agent, and 5-10 parts of seaweed extract.

2. The composite Chinese medicine antipruritic preparation according to claim 1, characterized in that: The effective components of the atractylodes are atractylodesin, 2-carene, atractylodes lactone, patchoulene, elemene, acetylatractyl alcohol and dehydrocostus ester.

3. The method for preparing the composite Chinese medicine antipruritic preparation according to claim 1, characterized in that: The steps include: Step 1: Grind Atractylodes lancea, mint, angelica dahurica, clove, Perilla frutescens, Asarum, dried ginger, mulberry leaf, Morus alba bark, Platycladus orientalis leaf, Boletus chinensis, Sichuan pepper, and Mangcao into 40-60 mesh coarse powder respectively; Step 2: Weigh the coarse powders of Atractylodes lancea, mint, Angelica dahurica, clove, Perilla frutescens, Asarum sieboldii, and dried ginger according to the composition ratio, mix them evenly, and place them in a glass container; add 75% alcohol in an amount of 8-10 times the weight of the powders for immersion to obtain an alcohol filtrate; Step 3: vacuum concentrate the alcohol filtrate obtained in step 2 until the concentrate is equivalent to the initial amount of drug powder, and the distilled alcohol is reserved; the alcohol concentrate is centrifuged at high speed and the supernatant is taken as the alcohol filtrate for later use; Step 4: adding 1%-2% of menthol and 1‰-1.5‰ of borneol to the distillate in step 3 to prepare an alcohol solution of menthol and borneol; Step 5: Weigh mulberry leaves, white mulberry bark, arborvitae leaves, Machelianthes, Sichuan pepper, and Mangcao coarse powder according to the group distribution ratio, mix them evenly, and place them in a glass container; add 3.5 degree vinegar with a weight of 3-6 times of the powder weight to soak; obtain vinegar filtrate; Step 6: vacuum concentrate the vinegar filtrate obtained in step 5 until the concentrate is equivalent to the initial amount of drug powder, and obtain the vinegar distillate for use; centrifuge the vinegar concentrate at high speed to obtain the supernatant as the vinegar filtrate for use; Step 7: Combine the alcohol and vinegar filtrates of step 3 and step 6, mix menthol and borneol with chitosan by spray drying to prepare microcapsules, and add the microcapsules to the alcohol solution; dilute the menthol and borneol alcohol solution at a volume ratio of 1:4-5 to obtain an antipruritic spray stock solution; Step 8: Evenly mix the antipruritic spray stock solution in step 7 with the vinegar distillate and glycerin in step 6 in a volume ratio of 3:1:1, and add 0.1‰-0.2‰ of rose essential oil and seaweed extract to the mixed solution to obtain an antipruritic spray.

4. The method for preparing the composite Chinese medicine antipruritic preparation according to claim 3, characterized in that: In step 2, add 75% alcohol in an amount of 8-10 times the weight of the powder for soaking. The alcohol liquid level should cover the medicinal materials. Stir evenly to make the medicinal materials fully contact with the solvent. Seal and let stand to prevent alcohol from volatilizing. After sufficient mixing, combine with ultrasonic treatment with a power of 200 W and a treatment time of 20 minutes to improve the extraction efficiency of the active ingredients. The soaking time is 48-72 hours, and intermittent stirring technology is used, stirring for 10 minutes every 6 hours.

5. The method for preparing the composite Chinese medicine antipruritic preparation according to any one of claims 3 and 4, characterized in that: In step 3, the alcohol concentrate is centrifuged at 8500 r / min for 10 min in a high-speed centrifuge, the supernatant is taken, and the precipitate is discarded; the supernatant is filtered with a 0.45 um organic microporous filter membrane to remove macromolecular substances, and the alcohol filtrate is taken for later use.

6. The method for preparing the composite Chinese medicine antipruritic preparation according to claim 3, characterized in that: In step five, add 3.5 degree vinegar which is 3-6 times the weight of the powder for soaking; stir evenly to make the medicinal material fully contact with the solvent, seal and let stand to prevent water from volatilizing; after fully mixing, combine with ultrasonic treatment with a power of 200 W and a treatment time of 20 minutes to improve the extraction efficiency of the active ingredients; soak for 48-72 hours, use intermittent stirring technology, and stir for 10 minutes every 6 hours.

7. The method for preparing the composite Chinese medicine antipruritic preparation according to any one of claims 3 and 6, characterized in that: In step six, the concentrate is centrifuged at 8500 r / min for 10 min in a high-speed centrifuge, the supernatant is taken, and the precipitate is discarded; the supernatant is filtered with a 0.45 um water-based microporous filter membrane to remove macromolecular substances, and the vinegar filtrate is taken for later use.

8. The method for preparing the composite Chinese medicine antipruritic preparation according to claim 3, characterized in that: The method further comprises: adding 75% alcohol in an amount of 8 to 10 times the weight of the medicinal powder for immersion in step 2, wherein the alcohol liquid level covers the medicinal material, stirring evenly to allow the medicinal material to fully contact with the solvent, sealing and standing to prevent the alcohol from volatilizing; the immersion time is 48 to 72 hours, and stirring regularly for 3 to 5 times; In step 3, the alcohol concentrate is centrifuged at 8500 r / min for 10 min in a high-speed centrifuge, the supernatant is taken, and the precipitate is discarded; the supernatant is filtered with a 0.45 um organic microporous filter membrane to remove macromolecular substances, and the alcohol filtrate is taken for use; In step 5, add 3.5 degree vinegar of 3-6 times the weight of the powder for soaking; stir evenly to make the medicinal material fully contact with the solvent, seal and let stand to prevent water from volatilizing; soak for 48-72 hours, and stir regularly 3-5 times; In step six, the concentrate is centrifuged at 8500 r / min for 10 min in a high-speed centrifuge, the supernatant is taken, and the precipitate is discarded; the supernatant is filtered with a 0.45 um water-based microporous filter membrane to remove macromolecular substances, and the vinegar filtrate is taken for later use.