Functional food composition for resisting fatigue and enhancing brain vitality and preparation method thereof

Abstract

The invention discloses a functional food composition for resisting fatigue and enhancing brain vitality. The functional food composition is prepared from the following medicinal materials in parts by weight: 5-900 parts of Chinese yam, 1-225 parts of American ginseng, 2-450 parts of angelica sinensis, 2-675 parts of codonopsis pilosula and 2-750 parts of raw astragalus membranaceus. The invention also discloses a preparation method of the functional food for resisting fatigue and enhancing brain vitality. The traditional Chinese medicine composition belongs to a medicinal and edible combination product, is good in safety, remarkable in anti-fatigue effect and lasting in curative effect, and is suitable for people suffering from physical insufficiency, physical power decline, physical weakness and weakness, lassitude, incoordination of energy, fatigue and the like.

Description

Technical Field

[0001] The present invention relates to a functional food, in particular to a functional food composition for resisting fatigue and enhancing brain activity. The present invention also relates to a preparation method of the functional food for resisting fatigue and enhancing brain activity. Background Art

[0002] It has been more than 100 years since German scholar Mosso began to study human fatigue in 1880. Many scholars have extensively studied fatigue from various perspectives and used different methods, and have given different definitions of fatigue. As early as 1904, a scholar (Ioteyko) proposed that fatigue was the result of sensory organs (muscle spindles) being stimulated by chemical products. Mosso proposed in 1915 that fatigue was a poisoning phenomenon caused by derivatives produced by chemical changes in cells. Karlsson proposed in 1980 that fatigue is the inability of muscles to produce the required or expected contraction force. Edwards proposed in 1982 that fatigue is the loss of the required or expected output power. At the Fifth International Conference on Sports Biochemistry in 1982, scholars reached a unified understanding of the definition of fatigue. The conference believes that fatigue, as a physiological phenomenon, refers to "the inability of the body's physiological processes to continue its functions at a certain level or the inability of various organs to maintain the predetermined exercise intensity."

[0003] Fatigue can lead to reduced athletic ability of athletes, reduced combat effectiveness of soldiers, reduced work efficiency, slow reaction and increased errors and accidents in the general population. However, fatigue is a protective reaction to prevent the body from excessive functional failure. When fatigue occurs, it reminds you to reduce work intensity or stop exercise to avoid damage to the body. If fatigue is not eliminated in time after it occurs, it will gradually accumulate, and excessive fatigue can accelerate aging and death. If the human body is in a state of fatigue for a long time, it may cause premature aging and fatigue syndrome. Fatigue syndrome may have the following phenomena: fatigue that is difficult to eliminate; boredom; irritability; lack of concentration; unexplained panic; dizziness; headache; constipation or diarrhea; skin spots; anorexia; abdominal distension; decreased sexual ability; high blood pressure; high blood fat; fatty liver.

[0004] With the acceleration of modern life and the intensification of social competition, many people feel tired due to work pressure, study pressure, lack of sleep, lack of exercise, improper diet or lack of vitamins. Many people use various methods to lose weight quickly. Although they lose weight, they often find that they become easily tired, weak and depressed. Those who practice fasting for health have to face the hunger during the fasting period and regulate the various stress states that occur during the fasting period.

[0005] Therefore, seeking a combination of medicine and food with anti-fatigue effects is one of the effective methods in contemporary times to relieve fatigue, refresh the mind, improve resistance, reduce hunger, regulate energy metabolism, regulate sub-health conditions, and slow down the aging of the body of middle-aged and elderly people.

[0006] At present, the anti-fatigue products on the market can be roughly divided into two categories. One category is mainly supplements, which aim to enhance the human body and keep the body in an excited state for a long time; the other category is mainly caffeinated foods, such as coffee, Red Bull, etc. Caffeine can excite the nervous system. However, the body's physical functions are limited, and excessive consumption of anti-fatigue supplements to enhance body functions will inevitably lead to damage to other body functions. Some solid beverages on the market can only supplement some necessary trace elements and energy for the human body, and have no substantial effect in anti-fatigue. Caffeinated foods will force the human body to maintain an excited state, but long-term consumption of caffeine will not only make the human body dependent on it, but also cause a series of hidden dangers to some organs of the human body such as the heart and liver. In Western medicine treatment, representative anti-fatigue clinical drugs include caffeine, amphetamine, methylphenidate, meclofenac, piracetam and modafinil, but they have great side effects, are easy to become addicted, and are expensive.

[0007] Compared with Western medicine, Chinese medicine is safer. Using Chinese medicine and Chinese medicine supplements for food and medicine supplements is a valuable experience of traditional Chinese medicine, especially the medicine and food homologous substances, which have the advantages of direct efficacy, extremely low toxicity, and short efficacy period.

[0008] Chinese invention patent document CN114010752A discloses a Chinese medicine composition for relieving physical fatigue, which is composed of the following components in parts by weight: 1-8 parts of ginseng, 3-6 parts of Euryale ferox, 1-3 parts of cinnamon bark, 1-3 parts of dried ginger, 5-60 parts of at least one of bull whip or dog whip or deer whip and 5-20 parts of single component in parts by weight, 0.5-3 parts of deer tendon, 1-6 parts of Alpinia oxyphylla, 3-6 parts of raspberry, 1-8 parts of Rosa laevigata, 3-6 parts of roasted Astragalus, 5-20 parts of male silkworm pupa, 3-6 parts of Cistanche deserticola, 1-3 parts of deer tail, 0-20 parts of antler glue, with obvious anti-fatigue, kidney-tonifying and yang-strengthening effects. But the ratio of yang-tonifying medicine in this composition is too high, which is not suitable for some people who are prone to getting angry, or people with heavy solid pathogens such as damp heat, turbid phlegm and blood stasis in the body take it, so it is inevitably restricted in the user population. Summary of the invention

[0009] The technical problem to be solved by the present invention is to provide a functional food composition for resisting fatigue and enhancing brain activity, which can effectively relieve fatigue.

[0010] In order to solve the above technical problems, the technical solution of the functional food composition for anti-fatigue and enhancing brain activity of the present invention is:

[0011] The preparation materials include the following medicinal materials in parts by weight:

[0012] 5-900 parts of Chinese yam, 1-225 parts of American ginseng, 2-450 parts of Chinese angelica, 2-675 parts of Codonopsis pilosula, and 2-750 parts of raw astragalus.

[0013] In another embodiment, the food composition further comprises a pharmaceutically acceptable carrier.

[0014] The present invention also provides a method for preparing functional food granules for resisting fatigue and enhancing brain activity, which is characterized by comprising the following steps:

[0015] The first step is to weigh the medicinal materials according to the following weight ratio and clean them;

[0016] 5-60 parts of Chinese yam, 1-15 parts of American ginseng, 2-30 parts of Chinese angelica, 2-45 parts of Codonopsis pilosula, 2-50 parts of raw astragalus;

[0017] The second step is to dry the medicinal materials and grind them into powder;

[0018] The third step is to fully mix the medicinal powder and then sterilize it at high temperature;

[0019] The fourth step is to add excipients, form granules, and form granules;

[0020] The fifth step is to sterilize again at high temperature.

[0021] In another embodiment, a pharmaceutically acceptable carrier is further added in the first step.

[0022] The present invention also provides a method for preparing a functional food paste for resisting fatigue and enhancing brain activity, which is characterized by comprising the following steps:

[0023] The first step is to weigh the medicinal materials according to the following weight ratio, wash them clean, decoct them and remove the residue to obtain the concentrated juice;

[0024] 10-900 parts of Chinese yam, 5-225 parts of American ginseng, 6-450 parts of Chinese angelica, 9-675 parts of Codonopsis pilosula, 8-750 parts of raw astragalus;

[0025] The second step is to add 200 to 500 parts of oligofructose, melt it into a paste, and you have it.

[0026] In another embodiment, a pharmaceutically acceptable carrier is further added in the first step.

[0027] The technical effects that can be achieved by the present invention are:

[0028] The present invention relates to a medicine-food combination product with good safety, significant anti-fatigue effect, and lasting therapeutic effect, and is suitable for any group of people with insufficient physical fitness, decreased physical strength, physical weakness, lack of energy, lack of energy, fatigue, etc.

[0029] The present invention can replenish the energy of essence and qi, and can quickly participate in the circulation of spirit and qi, so it can quickly relieve fatigue. It can not only treat the symptoms (quickly replenish essence and qi), but also slowly treat the root cause (the root of life). For those who are seriously deficient in physical and mental spirit after a serious illness or a long-term illness, they can slowly replenish their body, improve their physical fitness, enhance the overall functional health of the internal organs, and nourish the root of life. Therefore, the present invention is helpful for overworked people (physical overdraft, excessive brain work, excessive sexual intercourse); young and middle-aged people who are in a state of physical overdraft and mental fatigue due to long-term high-intensity labor; people with long-term low immunity, weak constitution, sub-health or serious illness, long-term illness; elderly and physically weak people; people with poor memory, insufficient brain function, etc. In addition, the present invention can also help people who lose weight to relieve hunger, and they will not lose essence and qi without eating, so as to achieve healthy weight loss. And it is very helpful for fasting. During the fasting period, Sanbao Dan can be used instead of daily diet. The Chinese medicines in the anti-fatigue edible and medicinal composition of the present invention are all edible and medicinal Chinese medicines, which are safe and effective to eat, very easy to promote and carry, and have broad market prospects. DETAILED DESCRIPTION

[0030] In order to make the purpose, technical solution and advantages of the embodiment of the present invention clearer, the technical solution of the embodiment of the present invention is clearly and completely described. Obviously, the described embodiment is a part of the embodiment of the present invention, not all of the embodiments. Based on the described embodiment of the present invention, all other embodiments obtained by ordinary technicians in the field without creative work belong to the scope of protection of the present invention. Unless otherwise defined, the technical terms or scientific terms used herein should be understood by people with ordinary skills in the field to which the present invention belongs. The "first", "second" and similar words used in this article do not indicate any order, quantity or importance, but are only used to distinguish different components. "Including" and similar words mean that the elements or objects appearing before the word include the elements or objects listed after the word and their equivalents, without excluding other elements or objects.

[0031] The functional food composition for resisting fatigue and enhancing brain activity of the present invention comprises the following medicinal materials in parts by weight:

[0032] 5-900 parts of Chinese yam, 1-225 parts of American ginseng, 2-450 parts of Chinese angelica, 2-675 parts of Codonopsis pilosula, and 2-750 parts of raw astragalus.

[0033] Furthermore, the composition also comprises a pharmaceutically acceptable carrier.

[0034] The method for preparing the functional food granules for resisting fatigue and enhancing brain activity of the present invention comprises the following steps:

[0035] The first step is to weigh the medicinal materials according to the following weight ratio and clean them;

[0036] 5-60 parts of Chinese yam, 1-15 parts of American ginseng, 2-30 parts of Chinese angelica, 2-45 parts of Codonopsis pilosula, 2-50 parts of raw astragalus;

[0037] Furthermore, a pharmaceutically acceptable carrier may be added.

[0038] The second step is to dry the medicinal materials and grind them into powder;

[0039] The third step is to fully mix the medicinal powder and then sterilize it at high temperature;

[0040] The fourth step is to add excipients, form granules, and form granules;

[0041] The fifth step is to sterilize again at high temperature.

[0042] The method for preparing the functional food paste prescription for resisting fatigue and enhancing brain activity of the present invention comprises the following steps:

[0043] The first step is to weigh the medicinal materials according to the following weight ratio, wash them clean, decoct them and remove the residue to obtain the concentrated juice;

[0044] 10-900 parts of Chinese yam, 5-225 parts of American ginseng, 6-450 parts of Chinese angelica, 9-675 parts of Codonopsis pilosula, 8-750 parts of raw astragalus;

[0045] The second step is to add 200 to 500 parts of oligofructose, melt it into a paste, and you have it.

[0046] The effects of each component of the present invention are as follows:

[0047] (1) Chinese Yam

[0048] It is the rhizome of Dioscorea opposita Thunb., a plant of the Dioscoreaceae family.

[0049] Anti-aging effect: Yam can significantly increase the activity of SOD (superoxide dismutase) and GSH-PX (glutathione antioxidant enzyme) in the brain and reduce the content of oxidation product MDA. Yam polysaccharides can enhance the learning ability of experimental animals and alleviate the spatial memory impairment of experimental animals. Its anti-aging effect may be achieved by repairing organ function and increasing the expression of klotho (klotho, anti-aging protein) gene in experimental animals.

[0050] Anti-Alzheimer's disease effect: Yam has multi-component, multi-target and multi-process characteristics. It mainly treats Alzheimer's disease by affecting the cholinergic nervous system and PI3K-Akt-mTOR signaling pathway (a key pathway for regulating growth and metabolism) and reducing the deposition of Ap protein.

[0051] Immunomodulatory effect: The various functional ingredients in yam can not only improve nonspecific immune function, but also enhance specific immune function. Yam water-soluble polysaccharides (WYPs) can significantly enhance the immune status of mouse models, and are dose-dependent, and can be developed as potential ingredients for immunomodulatory functional foods. Compared with other Chinese medicines, yam exhibits better immunomodulatory effects. By comparing the immune functions of four common Chinese medicines with medicinal and edible properties, such as Huai yam, coix seed, dandelion, and spiny jujube seed, it was found that Huai yam can promote the recovery of spleen index in immunosuppressed mice and provide phagocyte function.

[0052] Anti-tumor effect: Chinese yam and its leaves have shown effects on regulating key genes of cell pathways and anti-cell proliferation in different tumor cells. In addition, Chinese yam can also improve the fatigue of cancer-related organisms by regulating inflammatory response, oxidative stress response, and increasing energy supply. In a cancer-related mouse study, Chinese yam polysaccharides (CYP) increased the exhaustive swimming time of mice, the ATP (adenosine triphosphate) content of gastrocnemius muscle, reduced the levels of IL-1β (recombinant protein), MDA (Malondialdehyde, malondialdehyde), BUN (blood urea nitrogen) and LDH (lactate dehydrogenase) in the muscle, and upregulated SOD activity.

[0053] Other pharmacological effects: Yam also has many functions such as anti-oxidation, lowering blood sugar, lowering blood lipids, and regulating the spleen and stomach.

[0054] (2) American ginseng

[0055] It is the dried root of Panax quinquefolium L., a plant of the Araliaceae family.

[0056] Neuroprotective effect: The saponins in American ginseng can effectively regulate the central and peripheral nervous systems, improve learning and memory, and have potential anti-neurodegenerative functions.

[0057] Anti-fatigue effect: In recent years, Chinese scholars Li Ji and others have used American ginseng extract as a research object and mice as experimental animals to analyze its anti-fatigue effect. The results showed that the swimming time of Yin-deficiency mice in the drug-treated group increased significantly after being fed with American ginseng. Within a certain dosage range, the higher the dosage, the better the effect, indicating that American ginseng has the effect of relieving fatigue.

[0058] Antioxidative stress effect: Oxidative damage caused by oxygen free radicals can cause aging of the body, cell carcinogenesis, and cell or tissue damage. Studies have found that components such as American ginseng polysaccharides and saponins have strong antioxidant stress resistance. In a mouse model of chronic obstructive pulmonary disease (COPD) induced by secondhand smoke (CS), it was found that wild American ginseng (TSW) can significantly improve lung function, prevent the progression of COPD, and regulate proinflammatory factors (TNF-α, IL-6 and IL-1β) and oxidative stress index (SOD and MDA). The mechanism may be related to the ability of TSW to reduce oxidative stress and inflammatory response.

[0059] Immunomodulatory effect: American ginseng can significantly improve the body's immune function, both cellular and humoral immune functions. American ginseng can significantly increase the antibody titer, spleen weight, and lymphocyte transformation rate (referred to as lymphocyte transformation rate) of mice. American ginseng saponins can enhance the T cell function of mice, enhance the production of NINF and IL-2 in the spleen induced by ConA, and enhance the activity of NK cells. Total saponins can enhance the phagocytic function of mouse peritoneal macrophages.

[0060] Anti-tumor effect: The acetylene derivatives in American ginseng have a strong inhibitory effect on the proliferation of cultured tumor cells L-1210. American ginseng total saponins have anti-mutagenic effects and have a very obvious anti-DNA damage effect. It has a significant inhibitory effect on the proliferation of cancer cells such as lung cancer, liver cancer, and melanoma, among which Rh 2 (Ginsenoside) has a more prominent effect.

[0061] Anti-inflammatory effect: After pre-treatment of RAW6.1 macrophages with the neutral polysaccharide PPQN (150 μg / mL) isolated and purified from the root of American ginseng, PPQN had a significant inhibitory effect on the inflammatory cytokines NO, TNF-α, IL-β and IL-6, and had a significant anti-inflammatory effect.

[0062] Other pharmacological effects: American ginseng has anti-shock effect and can significantly improve the survival rate of rats with hemorrhagic shock; it has a sedative effect on the brain and a moderate excitatory effect on the vital center; it also has anti-hypoxia, anti-myocardial ischemia, anti-myocardial oxidation, increases myocardial contractility, anti-arrhythmia, anti-convulsant, hypoglycemic, hemostatic and anti-diuretic effects.

[0063] (3) Angelica

[0064] It is the root of Angelica sinensis (Oliv) Diels. of the Umbelliferae family.

[0065] Neuroprotective effect: Various bioactive components of angelica have protective and therapeutic potential for the nervous system, and show potential therapeutic effects in cerebral ischemic injury. Its protective effects include anti-inflammatory, promoting angiogenesis, and improving cerebral blood flow. Due to the first-pass elimination effect of the liver, the bioavailability of angelica volatile oil is low, but it can easily pass through the blood-brain barrier and enter the extracellular fluid of brain cells, especially the cerebellum. It is highly selective in the brain and has unique advantages in brain protection. The bioactive component butylphthalide in angelica volatile oil activates the protein kinase B / mammalian target of rapamycin signaling pathway, inhibits neuronal apoptosis and autophagy, and improves cognitive dysfunction in mice with repeated cerebral ischemia-reperfusion injury. The bioactive component Z-LIG can induce the clearance of amyloid precursor protein, inhibit neurotoxicity, and has a neuroprotective effect on Alzheimer's disease. In addition, the organic acid FA in angelica has an antidepressant effect. Angelica exerts brain protective activity in many aspects, has different pharmacological activities for the treatment of different diseases, and shows many important pharmacological effects.

[0066] Immunomodulatory effect: The immunomodulatory activity of Angelica sinensis is mainly manifested through ASP. Its regulatory mechanisms include promoting immune cell activation, regulating cytokine secretion, affecting immune organ function, promoting antibody production, and intervening in immune cell signaling pathways.

[0067] Anti-tumor effect: The anti-cancer effect of Angelica sinensis is mainly manifested through ASP (aspartic acid) and Z-LIG (Z-ligustilide). Its related anti-tumor mechanisms include anti-proliferation, induction of tumor cell apoptosis, anti-metastasis, inhibition of tumor angiogenesis, immune regulation and other molecular and signal mechanism pathways.

[0068] Other pharmacological effects: Angelica volatile oil can counteract the excitatory effect of adrenaline-posterior pituitary hormone or histamine on the uterus. Angelica water or alcohol-soluble non-volatile substances have an excitatory effect on the isolated uterus, which strengthens the contraction of the uterus. When a large amount or multiple doses are given, even tonic contraction may occur. The effect of alcohol-soluble substances is stronger than that of water-soluble substances. In the isolated toad heart perfusion experiment, the decoction containing volatile oil can significantly inhibit the contraction amplitude and contraction rate. Angelica extract has a significant effect of dilating the isolated guinea pig coronary artery and increasing coronary blood flow. Intravenous injection of this product in anesthetized dogs showed no significant change in heart rate, decreased coronary resistance and total peripheral resistance, significantly increased coronary blood flow, significantly decreased myocardial oxygen consumption, and an increasing trend in cardiac output and cardiac index. Angelica neutral oil also has a significant protective effect on experimental myocardial ischemia. Angelica and its sodium ferulate have a significant anti-thrombotic effect. Oral administration of Angelica water extract to mice can significantly promote the production of hemoglobin and red blood cells.

[0069] (4) Codonopsis pilosula

[0070] It is the root of Codonopsis pilosula (Franch.) Nannf., C.Pilosula Nannf. var.modesta (Nannf.) LTShen or C.tangshen Oliv. of the Campanulaceae family.

[0071] Anti-aging effect: Epigenetic changes are the main cause of mammalian aging, and restoring the integrity of the epigenome can reverse aging. Codonopsis plays an anti-aging role by regulating RNA (ribonucleic acid) molecules and protecting tissue structure, indicating that the mechanism of Codonopsis in delaying aging is related to epigenetics. Lu Codonopsis can improve the cognitive level of mice by improving cerebral ischemia, and play an anti-inflammatory role in the treatment of ischemic stroke. Codonopsis has the function of scavenging free radicals, can increase the activity of catalase (CAT) and superoxide dismutase (SOD), and reduce the content of lipid peroxidation and lipofuscin in tissues. It has antioxidant, free radical scavenging, inhibiting brain cell apoptosis, and delaying aging. Studies have shown that Codonopsis can significantly increase the thymus and spleen indexes, and can delay the atrophy of immune organs in aging.

[0072] Improve learning and memory effects: The Codonopsis polysaccharide-treated group can shorten the electric shock latency of mice with memory acquisition disorder model caused by scopolamine to varying degrees, improve spatial memory ability, and shorten the latency of finding the platform; it can prolong the memory latency of mice with memory consolidation disorder model caused by sodium nitrite and memory reproduction disorder model caused by 40% ethanol, and reduce the number of errors.

[0073] Tolerance to hypoxia and anti-fatigue effects: Codonopsis pilosula fermented liquid can improve the resistance of mice, enhance fatigue resistance and hypoxia tolerance. Studies have shown that Codonopsis pilosula broken wall powder can significantly prolong the weight-bearing swimming time of mice, and Codonopsis pilosula has an anti-fatigue effect.

[0074] Regulating immune function: Codonopsis pilosula extract and active ingredients can enhance the body's immune function by promoting T lymphocyte proliferation, regulating the secretion of inflammatory factors by T lymphocytes and macrophages, and maintaining the dynamic balance of immune cells.

[0075] Anti-inflammatory effect: Codonopsis polysaccharides and codonopsis saponins have good anti-inflammatory effects. Their anti-inflammatory mechanism is mainly related to adjusting the metabolism of intestinal flora by affecting the upstream and downstream factors of the NF-кB signaling pathway.

[0076] Anti-tumor effect: A variety of anti-cancer compounds have been found in Codonopsis extracts. Codonopsis polysaccharides have anti-tumor activity. Two new Codonopsis polysaccharides, CPS-3 and CPS-4, were isolated from Codonopsis total polysaccharides (CPS). CPS-3 has an inhibitory effect on the proliferation of human gastric adenocarcinoma cells (BGC-823); CPS-4 can inhibit the proliferation of human liver cancer cells (Bel-7402).

[0077] Other pharmacological effects: Codonopsis can regulate gastrointestinal motility and resist ulcers; it has effects on both excitatory and inhibitory neural processes; Codonopsis saponins can also excite the respiratory center; it has a short-term antihypertensive effect on animals, but can also raise the blood pressure of rabbits in late hemorrhagic shock; it can significantly increase rabbit blood sugar, and its blood sugar-raising effect is related to the sugar it contains; it can increase animal red blood cells, hemoglobin, and reticulocytes; it also has anti-radiation effects.

[0078] (5) Astragalus

[0079] The roots of Astragalus membranaceus Bge.var.mongholicus(Bge.)Hsiao and A.membranaceus(Fisch.)Bge. of the Leguminosae family.

[0080] Effects on the nervous system: High-dose Astragalus solution can improve the long-term memory ability of bees to a certain extent. Astragalus can not only improve memory, but also treat nervous system-related diseases and relieve pain. 1) Astragalus acts on multiple targets such as AKT1, TNF, IL1B, etc. through multiple components, mediating PI3K or Akt signaling pathways, TNF signaling pathways, etc., and participating in the treatment of Alzheimer's disease. 2) The active ingredients in Astragalus have strong binding activity with target proteins, and by regulating cell apoptosis and neuroinflammation, inhibiting the accumulation of amyloid plaques, and improving memory function, it plays a therapeutic role in Alzheimer's disease.

[0081] Protective effect on brain tissue: Astragalus polysaccharide can improve the permeability of the blood-brain barrier, stabilize the ischemic and hypoxic state of the brain environment, and protect the brain tissue of rats with arterial occlusion, which may be related to the inhibition of P2X7R channels. Astragalus has certain benefits for ischemic brain diseases.

[0082] Anti-aging and anti-fatigue effects: Astragalus can increase the activity of antioxidant enzymes, destroy free radicals accumulated in the body, and achieve the effect of preventing aging. In the natural aging model, Astragalus can significantly prolong the lifespan of mice and protect them from H 2 O 2 and paraquat, and can improve the climbing ability and food consumption of fruit flies.

[0083] Immunomodulatory effect: Astragalus decoction can significantly increase the content of cyclic nucleotides in mouse plasma and tissues. Cyclic nucleotides are important substances that affect the immune function of Astragalus. Astragalus has a significant effect on the antibody production function of the normal body and can increase the serum IgG content of mice. Clinical application of Astragalus and compound treatment with Astragalus as the main component has shown that it can increase the IgG level of patients with spleen deficiency, reduce the IgG level of patients with chronic hepatitis from the pre-treatment level to the normal range, and increase the secretory immunoglobulin content in the nasal secretions of patients with colds.

[0084] Anti-tumor effect: ① Astragalus polysaccharide (APS) has a wide range of biological activities. It has anti-cancer effects in vivo experiments, but it cannot directly kill cancer cells in vitro experiments, indicating that APS works by enhancing immune function. ② Astragalus decoction has been shown to induce the production of anti-cancer factor interferon in the body, and is a good interferon inducer. ③ Astragalus water decoction was orally fed to mice (25g / kg) for 5 days, which significantly promoted the function of phagocytic cells to phagocytize SRBC. ④ In vivo experiments, its hot water extract had an inhibition rate of 41.7% on mouse sarcoma-180. The alcohol soluble substance was ineffective.

[0085] Other pharmacological effects: It can promote the metabolism of the body and the renewal of serum and liver proteins. It has a significant diuretic effect, can eliminate urine protein in experimental nephritis, improve renal function and renal tissue pathological changes. It has a wide range of antibacterial effects. In cell culture, Astragalus can significantly increase the number of cells, promote cell growth, and prolong life. It can enhance myocardial contractility, protect the cardiovascular system, dilate coronary arteries and peripheral blood vessels, and lower blood pressure. It also has the effects of lowering blood lipids, resisting stress, resisting hypoxia, resisting radiation, protecting the liver, resisting arthritis, anti-inflammatory, and analgesic.

[0086] There are three talents in the universe: heaven, earth and man; there are three lights in the sky: the sun, the moon and the stars; and there are three treasures in man: essence, energy and spirit.

[0087] The Yellow Emperor's Classic of Internal Medicine says: The five internal organs are the guardians of the body and the strength of the body.

[0088] The Neijing theory believes that the five zang-organs jointly dominate the life, survival and health of the human body, and jointly determine the strength of the human body's vitality, the length of life, and the level of health. The five zang-organs each have their own qi, which together form the body's own qi. The sufficiency of qi determines the strength of the state of the spirit, and the spirit is a high-level performance that can only be manifested on the premise that the basic aspect, that is, the level of form, is strong. This performance comes from the form, and its state is supported by the form. When the form is complete, the spirit appears, and when the form is weak, the spirit leaves. Therefore, the classics say: When the form and spirit are both complete, and the muscles are as one, then the life span can be as long as the heaven and earth, and there is no end. In addition to replenishing the essence, qi and spirit, Sanbao Dan can also directly enhance the functions of the five zang-organs. After the functions of the five zang-organs are enhanced, they will find a better balance state by themselves, thereby driving the improvement and improvement of the overall health of the human body. The spirit is the master of the form! The form is the carrier of the spirit! The form-spirit is a relationship of mutual generation, mutual assistance, and mutual transformation. In this automatic life process, it will alleviate, improve, and even solve a series of disease states or problems.

[0089] "Suwen·Liujie Zangxiang Lun" says: "Heaven feeds people with five qi, and earth feeds people with five flavors. The five qi enter the nose and are stored in the heart and lungs, which make the five colors clear and the voice clear; the five flavors enter the mouth and are stored in the intestines and stomach. The flavors are stored to nourish the five qi. When qi is harmonious and the body fluids are formed, the spirit is born naturally." Heaven and earth not only give people life, but also give people the necessary conditions for survival, namely: air, water and food, which are the main sources of energy for the human body to survive and maintain life and health. The qi of heaven and earth exists in nature in thousands of forms. It constitutes the human body and the subtle substances that maintain human life activities, such as the qi of water and grain, and the qi of breathing, which need to be ingested by the human body. Human life originates from essence, and the maintenance of life depends on qi, and the phenomenon of life is spirit. The interaction, interdependence and coordination of essence, qi and spirit ensure the normal function of the body's physiological functions, which is the key to the survival of human life. As stated in Lei Zheng Zhi Cai: "The treasures of the human body are only essence, qi and spirit. Spirit is born from qi, qi is born from essence, essence turns into qi, qi turns into spirit, so essence is the root of the body, qi is the master of spirit, and form is the home of spirit." The so-called three treasures are essence, qi and spirit. Essence turns into qi, qi turns into spirit, and spirit gives rise to wisdom. Essence turns into qi, qi turns into spirit, which is the main manifestation of the relationship between form and spirit. When essence and blood are full, the form is healthy, and when qi is sufficient, the mind is wise. Essence, qi and spirit determine the preparation of form and spirit. When form and spirit are ready, essence, qi and spirit are strong. When essence is full, qi is sufficient, and spirit is vigorous, it is the external manifestation of the vigorous vitality of the human body. Health practitioners in all dynasties have paid attention to nourishing essence, qi and spirit. Many longevity masters have paid attention to preserving essence, nourishing qi and nurturing spirit. Qigong can transform essence into qi, qi into spirit, and spirit into emptiness, which can strengthen the body, improve the body's immune function, and eliminate diseases and prolong life.

[0090] According to the way, principle and number of the biochemical transformation of human essence, qi and spirit, the present invention is composed of codonopsis, astragalus, American ginseng, yam and angelica. Yam can nourish qi and yin, nourish spleen, lung and kidney, consolidate essence and stop leukorrhea, and is the main medicine. It is sweet and mild in nature, and can nourish qi and yin, and is not hot or dry, and is nourishing but not greasy. American ginseng is sweet and slightly bitter, and is good at nourishing qi and yin, clearing fire and producing body fluid. "Medical Records of Chinese and Western Medicine" mentioned: "American ginseng is cool and nourishing. Anyone who wants to use ginseng but cannot be warmed by the human body can use it." Angelica is sweet, spicy and warm, and is good at nourishing blood and activating blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relieving constipation. The Jingyue Complete Works of Materia Medica mentions: "Danggui has a sweet and heavy taste, so it can specifically nourish blood. Its qi is light and pungent, so it can also promote blood circulation. It can nourish and move while nourishing, and can nourish while moving. It is truly a qi medicine for blood, and also a holy medicine for blood. It can nourish blood, replenish qi and produce essence when used as a supplement. American ginseng and angelica are both ministers, assisting the main medicine to replenish qi and produce blood. They have flexible functions and are not greasy. Codonopsis is an adjuvant, which is sweet and mild in nature, nourishes the spleen and stomach, strengthens the middle qi, and invigorates the clear yang. It is a good product commonly used to nourish the middle qi. "Bencao Zhengyi" said: "Codonopsis can nourish the spleen and stomach, moisten the lungs and produce fluid, and strengthen the middle qi. It is not very different from ginseng. What is particularly valuable is that it can strengthen the spleen without being dry; nourish stomach yin without being damp; moisten the lungs without being cold; nourish the blood without being too greasy; invigorate the clear yang, and vibrate the middle qi without the disadvantages of being rigid and dry." Astragalus is a guiding drug, and it is used for its good effects of nourishing qi and raising yang, and strengthening the defense and consolidating the exterior.

[0091] All medicines work together, following the endless mechanism of the essence, qi and spirit of heaven and earth, and strengthening the five internal organs. It is the key to achieve the joint benefit and coordination of essence, qi and spirit, and in the process of benefiting, the essence, qi and spirit are increased comprehensively, and the balance of yin and yang is achieved, the monarch and the minister are in harmony, replenishing qi, raising yang, generating body fluid, nourishing yin, replenishing essence and generating blood, both separate and combined, although it is a quick supplement, it replenishes qi without generating heat, nourishes yin without being greasy, and is balanced and coordinated, yin and yang are balanced, then the spirit is cured.

[0092] In summary, its uses are: to tonify Qi and replenish Qi, one; to replenish Qi and nourish Yin, two; to produce body fluids and blood, three; to replenish both Yin and Yang, four; to have the same effect on Qi and blood, five; to keep the five internal organs intact, six; and to strengthen the internal organs, seven.

[0093] When Qi and blood are full, essence will be full; when essence and blood are generated, Qi will be sufficient; when Qi is transformed, spirit will be complete.

[0094] All the medicines work together to harmonize yin and yang, replenish qi and blood, strengthen the internal organs, and make the three treasures self-sufficient.

[0095] Example 1

[0096] A functional food granule for resisting fatigue and enhancing brain activity, the raw materials of which are as follows: 5 parts of yam, 1 part of American ginseng, 2 parts of angelica, 2 parts of codonopsis, and 2 parts of raw astragalus.

[0097] The specific preparation method is as follows:

[0098] 1. Weigh the medicinal materials according to the above weight ratio and wash them clean;

[0099] 2. Dry the medicinal materials and grind them into powder;

[0100] 3. After fully mixing the medicinal powder, sterilize it at a high temperature above 100°C;

[0101] 4. Add excipients, shape and granulate to form fine particles;

[0102] 5. Carry out high temperature sterilization at above 100℃ again.

[0103] Example 2

[0104] A functional food granule for resisting fatigue and enhancing brain activity, the raw materials of which are as follows: 30 parts of Chinese yam, 6 parts of American ginseng, 12 parts of Chinese angelica, 20 parts of Codonopsis pilosula, and 15 parts of raw astragalus. The specific preparation method is as follows:

[0105] 1. Weigh the medicinal materials according to the above weight ratio and wash them clean;

[0106] 2. Dry the medicinal materials and grind them into powder;

[0107] 3. After fully mixing the medicinal powder, sterilize it at a high temperature above 100°C;

[0108] 4. Add excipients, shape and granulate to form fine particles;

[0109] 5. Carry out high temperature sterilization at above 100℃ again.

[0110] Example 3

[0111] A functional food granule for resisting fatigue and enhancing brain activity, the raw materials of which are as follows: 60 parts of Chinese yam, 15 parts of American ginseng, 30 parts of Chinese angelica, 45 parts of Codonopsis pilosula, and 50 parts of raw Astragalus. The specific preparation method is as follows:

[0112] 1. Weigh the medicinal materials according to the above weight ratio and wash them clean;

[0113] 2. Dry the medicinal materials and grind them into powder;

[0114] 3. After fully mixing the medicinal powder, sterilize it at a high temperature above 100°C;

[0115] 4. Add excipients, shape and granulate to form fine particles;

[0116] 5. Carry out high temperature sterilization at above 100℃ again.

[0117] Example 4

[0118] A functional food paste recipe for resisting fatigue and enhancing brain activity, the raw materials of which are as follows:

[0119] 10 parts of Chinese yam, 5 parts of American ginseng, 6 parts of Chinese angelica, 9 parts of Codonopsis pilosula, and 8 parts of raw astragalus.

[0120] The specific preparation method is as follows:

[0121] 1. Weigh the medicinal materials according to the above weight ratio, clean them, decoct them, remove the residue, and take the concentrated juice;

[0122] 2. Add 200 parts of oligofructose and melt it into a paste.

[0123] Example 5

[0124] A functional food paste recipe for resisting fatigue and enhancing brain activity, the raw materials of which are as follows:

[0125] 450 parts of Chinese yam, 100 parts of American ginseng, 180 parts of Chinese angelica, 300 parts of Codonopsis pilosula, and 300 parts of raw astragalus.

[0126] The specific preparation method is as follows:

[0127] 1. Weigh the herbs according to the above weight ratio, wash them, add 8 times the amount of water, boil them for 1 hour, remove the residue and take the concentrated juice;

[0128] 2. Add 300 parts of oligofructose and melt it into a paste.

[0129] Example 6

[0130] A functional food paste recipe for resisting fatigue and enhancing brain activity, the raw materials of which are as follows:

[0131] 900 parts of Chinese yam, 225 parts of American ginseng, 450 parts of Chinese angelica, 675 parts of Codonopsis pilosula, and 750 parts of raw astragalus.

[0132] The specific preparation method is as follows:

[0133] 1. Weigh the herbs according to the above weight ratio, wash them, add 8 times the amount of water, boil them for 1 hour, remove the residue and take the concentrated juice;

[0134] 2. Add 500 parts of oligofructose and melt it into a paste.

[0135] Comparative Example 1

[0136] This comparative example is based on Example 1, but uses less yam, and its preparation method is the same as that of Example 1.

[0137] Comparative Example 2

[0138] This comparative example is based on Example 4, but uses less Astragalus. Its preparation method is the same as that of Example 4.

[0139] Comparative Example 3

[0140] This comparative example is based on Example 1, and uses less raw astragalus and codonopsis, and its preparation method is the same as that of Example 1.

[0141] Comparative Example 4

[0142] This comparative example is based on Example 4, with less use of Angelica sinensis, American ginseng and Chinese yam, and its preparation method is the same as that of Example 4.

[0143] The effect test of the present invention is as follows:

[0144] Experiment 1:

[0145] 60 healthy adult men (aged 25 to 35 years old) were selected. They were in good health and had no obvious brain, heart, liver, lung, kidney or blood diseases. The safety index test was qualified. (Safety indicators include mental, sleep, diet, defecation and urination, heart rate, blood pressure, blood routine, urine routine test, and electrocardiogram test) Except for heart rate, other safety indicators were measured only before the start of the experiment to ensure that the physical health of the subjects met the test requirements. They were randomly divided into 10 groups, each with 6 people, 6 of which were given the compositions prepared by Examples 1-6 of the present invention; the other 4 groups were given the compositions prepared by Comparative Examples 1-4 of the present invention, 20 grams of paste or granules each time.

[0146] This experiment uses the self-control method to record the heart rate value in a calm state. 60 healthy adult men complete 40 squats at an average speed of 1 second per squat. The heart rate value at the moment of exercise completion and the time required to return to the heart rate value in a calm state (±5) are recorded. Repeat the experiment, take 20 grams of the above paste or granules before exercise, and compare the time required to complete the heart rate value at the moment of exercise and return to the heart rate value in a calm state in the two experiments to verify the anti-fatigue effect of the anti-fatigue functional food composition. (During the test, it is forbidden to take any anti-fatigue drugs and eat anti-fatigue foods)

[0147] The experimental data were processed using SPSS16.0 software, and the differences among the groups were analyzed using one-way ANOVA and LSD method (Least Significant Difference). P≦0.05 indicated that the difference was statistically significant.

[0148]

[0149] Table 1 Effects of the functional food compositions of Examples 1-6 and Comparative Examples 1-4 on the heart rate of human body during exercise

[0150] As can be seen from Table 1, by comparing the administration with that without administration, the functional food compositions prepared by the six formulations of Examples 1-6 can reduce the heart rate immediately after exercise completion and the time required to restore the calm heart rate, that is, enhance the body's anti-fatigue ability ((P﹤0.01), among which Example 5 has the best effect. Then, when Examples 1-3 are compared with Examples 4-6 one by one, the granules prepared by Examples 1-3 are not as effective as the pastes prepared by Examples 4-6 in reducing the heart rate immediately after exercise completion and the time required to restore the calm heart rate (P﹤0.05). When Examples 1-6 are compared with Comparative Examples 1-4 one by one, Examples 1-6 show more obvious anti-fatigue effects.

[0151] Experiment 2:

[0152] 120 subjects diagnosed with chronic fatigue syndrome (CFS) were randomly divided into 10 groups, each with 12 people. Six of the groups were given the compositions prepared in Examples 1-6 of the present invention, and the other four groups were given the compositions prepared in Comparative Examples 1-4 of the present invention. Each group took the ointment or granules orally once a day, 20 grams each time, for 30 consecutive days.

[0153] Diagnostic criteria: The diagnostic criteria for CFS are based on the diagnostic criteria revised by the US CDC in 1994.

[0154] Inclusion and exclusion criteria: Those who met the diagnostic criteria for CFS, aged 20 to 50 years, and voluntarily participated in this study and signed the informed consent form were included. Chronic fatigue that could be explained by the primary disease, such as chronic liver disease, tuberculosis, diabetes, tumors, cardiovascular and cerebrovascular diseases, and blood diseases, as well as pregnant and lactating women were excluded.

[0155] Efficacy judgment criteria: Cured: The main clinical symptoms and concomitant symptoms completely disappear, and the patient can adapt to the normal social life and work rhythm; Markedly effective: The main clinical symptoms and concomitant symptoms disappear ≥2 / 3, the fatigue is mild, and there is basically no impact or very little impact on work and life; Effective: The main clinical symptoms and concomitant symptoms disappear ≥1 / 3; the fatigue is obvious, and the patient can only engage in lighter work and life; Ineffective: The main clinical symptoms and concomitant symptoms disappear <1 / 3 or there is no improvement, the patient is extremely tired, and it is difficult to adhere to normal work and life.

[0156] Scale scores: Bell's CFS score table, fatigue scale and fatigue assessment scale were measured on patients before and after treatment. The scoring standards of each scale were calculated according to the scale evaluation rules.

[0157] Statistical methods: SPSS16.0 software was used to analyze the data. The measurement data were expressed as mean ± standard deviation. Indicates that the comparison is done by t test and the counting data is done by X 2 P<0.05 was considered statistically significant.

[0158] Treatment Effect:

[0159]

[0160]

[0161] Table 2 Comparison of clinical efficacy among 10 groups (%)

[0162] From the data in Table 1, it can be seen that the effective rate of the composition prepared in Examples 1-6 for treating CFS is significantly higher than that of the composition prepared in Comparative Examples 1-4 (P<0.05). From the results of Examples 1-6, it can be seen that the number of cured and markedly effective patients in the paste group is slightly higher than that in the granule group.

[0163]

[0164] Table 3 Comparison of scores of each scale in 10 groups before and after treatment (points, )

[0165] In Table 3, "real" refers to the embodiment group, and "comparative" refers to the comparative group. As shown in Table 3, there was no statistically significant difference in the BELL's CFS score, fatigue scale score, and fatigue assessment scale score of the 10 groups of patients before treatment; after treatment, they all improved compared with before treatment (P<0.01), and the improvement in the embodiment group was more obvious, and the difference was statistically significant (P<0.01).

[0166] Comparative Example 1 used less yam, and although the BELL's CFS score, fatigue scale score, and fatigue rating scale score were improved compared with before treatment, the effect was not as good as that of Example 1. It can be seen that the use of yam together with the other four drugs can produce a synergistic effect, thereby alleviating discomfort symptoms such as fatigue.

[0167] Comparative Example 2 used less Astragalus, although the BELL's CFS score, fatigue scale score, and fatigue rating scale score were improved compared with before treatment, the effect was not as good as that of Example 4. It can be seen that the use of Astragalus together with the other four drugs can produce a synergistic effect, thereby alleviating discomfort symptoms such as fatigue.

[0168] Comparative Example 3 used less raw astragalus and codonopsis, although the BELL's CFS score, fatigue scale score, and fatigue rating scale score were improved compared with before treatment, but the effect was not as good as that of Example 1. It can be seen that raw astragalus and codonopsis can produce a synergistic effect with the other three drugs, thereby alleviating discomfort symptoms such as fatigue.

[0169] Comparative Example 4 used less of the three drugs of Angelica sinensis, American ginseng and Chinese yam, although the BELL's CFS score, fatigue scale score and fatigue rating scale score were improved compared with before treatment, but the effect was not as good as that of Example 4. It can be seen that the use of the three drugs of Angelica sinensis, American ginseng and Chinese yam together with the other two drugs can produce a synergistic effect, thereby alleviating discomfort symptoms such as fatigue.

[0170] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these changes and modifications.

Claims

1. A functional food composition for resisting fatigue and enhancing brain activity, characterized in that: The preparation materials include the following medicinal materials in parts by weight: 5-900 parts of Chinese yam, 1-225 parts of American ginseng, 2-450 parts of Chinese angelica, 2-675 parts of Codonopsis pilosula, and 2-750 parts of raw astragalus.

2. The functional food composition for resisting fatigue and enhancing brain activity according to claim 1, characterized in that: The food composition further comprises a pharmaceutically acceptable carrier.

3. A method for preparing functional food granules for anti-fatigue and brain activity enhancement, characterized in that: The following steps are involved: The first step is to weigh the medicinal materials according to the following weight ratio and clean them; 5-60 parts of Chinese yam, 1-15 parts of American ginseng, 2-30 parts of Chinese angelica, 2-45 parts of Codonopsis pilosula, 2-50 parts of raw astragalus; The second step is to dry the medicinal materials and grind them into powder; The third step is to fully mix the medicinal powder and then sterilize it at high temperature; The fourth step is to add excipients, form granules, and form granules; The fifth step is to sterilize again at high temperature.

4. The method for preparing the functional food granules for resisting fatigue and enhancing brain activity according to claim 3, characterized in that: In the first step, a pharmaceutically acceptable carrier is added.

5. A method for preparing a functional food paste for resisting fatigue and enhancing brain activity, characterized in that: The following steps are involved: The first step is to weigh the medicinal materials according to the following weight ratio, wash them clean, decoct them and remove the residue to obtain the concentrated juice; 10-900 parts of Chinese yam, 5-225 parts of American ginseng, 6-450 parts of Chinese angelica, 9-675 parts of Codonopsis pilosula, 8-750 parts of raw astragalus; The second step is to add 200 to 500 parts of oligofructose, melt it into a paste, and you have it.

6. The method for preparing the functional food paste for resisting fatigue and enhancing brain activity according to claim 5, characterized in that: In the first step, a pharmaceutically acceptable carrier is added.

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