Manufacturing method of rivanol wet compress tissue for skin injury based on dermatology department

Abstract

The invention relates to the field of dermatological skin injury, and discloses a dermatological skin injury-based rivanol wet compress towel manufacturing method, which comprises: 1, preparing a 0.1% rivanol solution; 2, taking the sterilized dressing, soaking and adsorbing 45ml of 0.1% rivanol solution to obtain 0.1% rivanol dressing; thirdly, the 0.1% rivanol dressing is placed on a multifunctional pillow type packaging machine to be packaged in bags according to regulations, and the packaged 0.1% rivanol dressing is obtained; 4, 0.1% of rivanol dressing is detected, the drug treatment effect can be rapidly, efficiently and fully achieved, and meanwhile, due to the fact that the novel dressing is unified in standard and preparation, sampling detection and sealed low-temperature storage are adopted, and the stable effect can be achieved in treatment.

Description

Technical Field

[0001] The invention relates to the field of dermatological skin damage, and in particular to a method for preparing a rivano wet compress for dermatological skin damage. Background Art

[0002] 0.1% rivanol solution (also known as ethacridine solution) is a common topical drug widely used in the treatment of skin diseases. The solution has antibacterial, anti-inflammatory and soothing effects and can be used to relieve and cure symptoms such as wounds, burns, eczema, and dermatitis.

[0003] Therapeutic features of 0.1% rivanol solution: 1. Antibacterial effect: 0.1% rivanol solution can effectively kill bacteria and fungi, and has significant therapeutic effects on infectious skin diseases. The active ingredients in its ingredients can penetrate the skin and directly act on the lesion site to inhibit the growth and reproduction of pathogenic microorganisms. The effectiveness is not reduced even in the presence of protein and pus and blood. [1] .

[0004] Anti-inflammatory effect: 0.1% rivanol solution has the ability to inhibit inflammatory reactions, reduce symptoms such as redness, swelling, itching and pain in skin lesions, and accelerate the repair and regeneration of skin tissue. 3. Hydration: The ingredients in 0.1% rivanol solution can absorb and lock in moisture, increase the skin's moisturizing properties, and are particularly effective for dry and flaky skin.

[0005] Application scope of 0.1% rivanol solution: 1. Wound care: In case of minor cuts, abrasions and erosions on the skin surface, 0.1% rivanol solution can be used to gently clean the wound surface, kill bacteria and accelerate wound healing. [6-7] 2. Burn care: 0.1% rivanol solution has anti-inflammatory, analgesic and burn healing effects. The solution can be applied to the affected area. 3. Eczema and skin inflammation: In case of eczema and skin inflammation, applying 0.1% rivanol solution externally can calm itching, reduce redness and swelling, and repair the skin. 0.1% rivanol solution has antibacterial, anti-inflammatory and soothing effects, and is suitable for the treatment of a variety of skin diseases.

[0006] 0.1% rivanol wet compress technique: soak several pieces of gauze or saline pads of appropriate size in the prepared 0.1% rivanol solution and boil it. When the temperature drops to room temperature, take out the gauze pieces or saline pads and apply them to the lesions for 10 minutes, changing the gauze or saline pads twice in between. [2] . Guo Jian [3] Studies such as those by others suggest that ethacridine solution has a higher cell proliferation inhibition rate, lower cell proliferation toxicity, and is more aesthetically pleasing. [4] The study reported that the use of ethacridine solution for wet compress has a strong bactericidal effect, promotes rapid tissue repair, and can significantly reduce the pain of patients. [5]The study of ethacridine solution wet compress in the treatment of erysipelas skin redness, swelling and pain has a good effect.

[0007] Wet compress therapy is also known as soaking therapy. Wet compress therapy is a method of achieving the purpose of treatment through the physical effect of wet compress on the affected area and the pharmacological effect of different drugs on the affected area. Wet compress therapy comes from the "Essence of Surgery" by Qi De of the Yuan Dynasty, which says: "Wet compress therapy, if the sores do not subside after one or two days, they must be sprayed with hot water. If they are on the limbs, soak them." Modern doctors divide wet compresses into cold wet compresses and hot wet compresses according to the different temperatures of the liquid medicine. Under the guidance of the holistic concept of traditional Chinese medicine and syndrome differentiation and treatment, this method combines different Chinese medicines to exert therapeutic effects. Wet compresses have the functions of inhibiting exudation, astringing and relieving itching, reducing swelling and relieving pain, controlling infection, and promoting skin healing.

[0008] Cold wet compress is to use a cold solution close to room temperature (usually around 10°C), soak it with gauze, wring it out and apply it to the affected area. It is suitable for acute dermatitis and erosion and exudation. [9] It is believed that cold and wet compress can promote the expansion of local tissue blood vessels, improve microcirculation, and improve tissue metabolism by stimulating the body's own immunity, thus achieving the purpose of sterilization and anti-inflammation. Wang Yanchen

[10] Cold wet compress combined with loratadine was used to treat acute eczema. The total effective rate of the treatment group was 97.5%, which was significantly higher than the 82.5% of the control group (loratadine). Zhang Peng

[11] Cold wet compress and calamine lotion were used to treat eczema, and the control group used calamine lotion externally. The results showed that the efficacy of the observation group was significantly better than that of the control group. :Luo Zhaocai

[12] The total effective rate of the observation group in the treatment of Malassezia folliculitis was 100%, significantly higher than the 86.0% of the control group (Caile lotion combined with far infrared). Liu Hongjun

[13] Malassezia folliculitis was treated with Chinese medicine combined with naftifine ketoconazole cream. After 2 weeks of drug withdrawal, the fungus clearance rates in the observation group and the control group (naftifine ketoconazole cream) were 97.14% and 71.43%, respectively.

[0009] The 0.1% rivanol wet compress solution commonly used in dermatology is a pre-prepared solution, which is applied by dipping a wet gauze in the rivanol solution. The preparation of clinical solutions is cumbersome, the stability of the solution is uncertain, and the sterility cannot be guaranteed; the dressing also needs to be made temporarily, which increases the workload of nurses and is easily contaminated, making it inconvenient for outpatients to use it outside the hospital. Therefore, we proposed a method for making rivanol wet compresses for skin injuries in dermatology. Summary of the invention

[0010] 1. Technical issues to be solved

[0011] In view of the shortcomings of the prior art, the present invention provides a method for preparing a rivanol wet compress for skin damage in dermatology. The 0.1% rivanol wet compress material prepared by the present invention can be taken as needed, is convenient and does not waste the liquid medicine, and can also ensure its stability.

[0012] (II) Technical solution

[0013] To achieve the above-mentioned purpose, the present invention provides the following technical solution: a method for preparing a rivanol wet compress for skin damage in dermatology, comprising the following steps:

[0014] Step 1: Prepare 0.1% rivanol solution;

[0015] Step 2: Take the sterilized dressing, soak and absorb 45 ml of 0.1% rivanol solution to obtain 0.1% rivanol dressing;

[0016] Step 3: placing the 0.1% rivano dressing on a multifunctional pillow packaging machine and performing bag packaging according to regulations to obtain packaged 0.1% rivano dressing;

[0017] Step 4: Test the 0.1% rivanol dressing.

[0018] Preferably, the specific content of the first step is as follows: take 1g of rivanol powder, put it into 900ml of purified water, filter it after it is completely dissolved and cooled, add purified water to 1000ml from the filter, and stir well.

[0019] Preferably, the soaking time in the second step is 14 min-16 min.

[0020] Preferably, the sterilized dressing in the second step is 2 layers of 20cm×40cm thick medical degreased sterilized gauze for wound surface.

[0021] Preferably, the packaging bag in the third step is an aluminum foil bag.

[0022] Preferably, the detection content in the fourth step is as follows:

[0023] S1: The appearance should be smooth, the fonts should be clearly printed, the contents should be complete and correct, the packaging should be tightly sealed without damage, and it should be slightly flattened with the palm of your hand until no leakage occurs;

[0024] S2: Randomly select 5 bags of wet compress towelettes, open them and check them separately. The wet compress towelettes should be free of color difference, color spots and mildew spots.

[0025] S3: Assay;

[0026] S4: The total number of bacteria and fungi should not exceed 100 / ml respectively, and Staphylococcus aureus and Pseudomonas aeruginosa should not be detected.

[0027] Preferably, the content determination includes the following contents:

[0028] Take 3 bags of packaged 0.1% rivanol dressing, open them and dehydrate the adsorbed rivanol solution into a dry and clean 100ml beaker, accurately measure 5ml of this product, put it in a 50ml volumetric flask, add fresh purified water to the scale, shake well, accurately measure 10ml of the diluent, add 0.5g of mannitol, warm until dissolved, quickly cool to room temperature, add 1 drop of phenolphthalein indicator solution, and use sodium hydroxide titration solution (0.1mol / L) until pink appears. The content determination results of 3 batches of samples are obtained, and each 1ml of sodium hydroxide titration solution (0.1mol / L) is equivalent to 6.183mg of HBO.

[0029] Preferably, the method for using the 0.1% rivano dressing is as follows:

[0030] Take out 0.1% rivanol dressing and apply it closely to the affected skin, replace with a new one after 10-15 minutes, and replace 2-3 pieces in a row (about 1 hour), 2 times a day, until the skin lesions are completely dry and no exudates, or as directed by the doctor.

[0031] Preferably, the 0.1% rivanol dressing can be used after being heated or refrigerated according to the ambient temperature and the patient's condition.

[0032] (III) Beneficial effects

[0033] Compared with the prior art, the present invention provides a method for preparing a rivano wet compress for skin damage in dermatology, which has the following beneficial effects:

[0034] 1. The innovative design of the 0.1% rivano wet compress material structure prepared by the method for preparing rivano wet compress for skin damage in dermatology can quickly, efficiently and fully exert the therapeutic effect of the drug. At the same time, since the new dressing has unified standards, unified formulation, will adopt sampling inspection and sealed low-temperature storage, it will play a stabilizing role in treatment.

[0035] 2. Compared with the previous wet compress method, which uses rivanol solution, treatment bowl, gauze and other dressings to prepare on-site, the method makes it more difficult for nursing staff and patients to use and increases the workload of nurses. The uncertainty of material collection also leads to waste of medical equipment and wet compress liquid, and the large amount of materials and the non-sealed nature make it inconvenient to refrigerate and store. This design is an independent 0.1% rivanol wet packaging for use at any time, which can improve the portability of use, optimize the nursing operation process, and save nursing manpower and material costs.

[0036] 3. The manufacturing method of the rivano wet compress for skin damage in dermatology uses cluster packaging, which is convenient for storage and refrigeration. In addition to being used in clinical practice, outpatients can also use it at home according to the doctor's advice, which also increases the economic benefits of the hospital and improves the satisfaction of patients and nursing. At the same time, the nursing operation process is optimized, which is convenient for patients to operate by themselves and effectively reduces the cost of manpower and material resources. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 It is a schematic diagram of the process of the present invention. DETAILED DESCRIPTION

[0038] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0039] See also Figure 1 , a method for preparing a rivano wet compress for skin damage in dermatology, comprising the following contents:

[0040] Take 2 layers of 20cm×40cm thick medical degreased sterilized gauze as the cutter, absorb 45ml 0.1% rivanol solution to prepare boric acid wet compress. ①: Take 1g rivanol powder, put it in 900ml purified water, wait for it to be completely dissolved and cooled, filter it, add purified water to 1000ml from the filter, stir it evenly, and the rivanol solution will be used after passing the inspection. ② Take the sterilized dressing (confirm that each piece is 2 layers of 20cm×40cm thick degreased gauze) and soak it in the rivanol solution for about 15 minutes. After the drug content of each dressing reaches the standard, place it on a multifunctional pillow packaging machine and carry out bag packaging according to regulations. In order to avoid light, aluminum foil bags are used for packaging. ③ In order to ensure the quality of the wet compress and ensure the safety and effectiveness of clinical treatment, the following indicators are specially controlled for the treatment characteristics of the wet compress: a. Appearance: The appearance of this product should be flat, the font printing should be clear, and the content should be complete and correct; the packaging seal should be tight and not damaged, and it should be slightly flattened with the palm of your hand until no leakage occurs. b. Inspection: Randomly select 5 bags of wet compresses, open them and check them separately. The wet compresses should have no color difference, color spots, or mold spots. C. Content determination: Take 3 bags of rivanol wet compresses, open them and dehydrate the rivanol solution adsorbed to a dry and clean 100ml beaker, accurately measure 5ml of this product, place it in a 50ml volumetric bottle, add fresh purified water to the scale, and shake well. Accurately measure 10ml of the diluent, add 0.5g of mannitol, warm it slightly until it dissolves, quickly cool it to room temperature, add 1 drop of phenolphthalein indicator solution, and use sodium hydroxide titration solution (0.1mol / L) to drop until it turns pink. Each 1ml of sodium hydroxide titration solution (0.1mol / L) is equivalent to 6.183mg of HBO3 batch sample content determination results. d. According to the method of Appendix (V) of the 2000 edition of the Chinese Pharmacopoeia, the total number of bacteria and molds is not more than 100 / ml, and Staphylococcus aureus and Pseudomonas aeruginosa cannot be detected.

[0041] Directions: Wash your hands, take out the Livanol wet compress and apply it to the affected area of ​​the skin. Replace it with a new one after 10-15 minutes. Replace 2-3 pieces (about 1 hour) twice a day until the skin lesions are completely dry and no exudates or follow the doctor's advice. The wet compress can be heated or refrigerated before use according to the ambient temperature and the patient's condition.

[0042] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A method for preparing a rivano wet compress for skin damage in dermatology, characterized in that: The following steps are involved: Step 1: Prepare 0.1% rivanol solution; Step 2: Take the sterilized dressing, soak and absorb 45 ml of 0.1% rivanol solution to obtain 0.1% rivanol dressing; Step 3: placing the 0.1% rivano dressing on a multifunctional pillow packaging machine and performing bag packaging according to regulations to obtain packaged 0.1% rivano dressing; Step 4: Test the 0.1% rivanol dressing.

2. The method for preparing the rivano wet compress for skin damage in dermatology according to claim 1, characterized in that: The specific content of the first step is as follows: take 1g of rivanol powder, put it into 900ml of purified water, filter it after it is completely dissolved and cooled, add purified water to 1000ml from the filter, and stir it well.

3. The method for preparing the rivano wet compress for skin damage in dermatology according to claim 1, characterized in that: The soaking time in the second step is 14 min-16 min.

4. The method for preparing the rivano wet compress for skin damage in dermatology according to claim 1, characterized in that: The sterilized dressing in the second step is 2 layers of 20cm×40cm thick medical degreased sterilized gauze for wound surface.

5. The method for preparing the rivano wet compress for skin damage in dermatology according to claim 1, characterized in that: The packaging bag in the third step is an aluminum foil bag.

6. The method for preparing the rivano wet compress for skin damage in dermatology according to claim 1, characterized in that: The detection contents in the fourth step are as follows: S1: The appearance should be smooth, the fonts should be clearly printed, the contents should be complete and correct, the package should be tightly sealed without damage, and it should be slightly flattened with the palm of your hand until no leakage occurs; S2: Randomly select 5 bags of wet compress towelettes, open them and check them separately. The wet compress towelettes should be free of color difference, color spots and mildew spots. S3: Assay; S4: The total number of bacteria and fungi should not exceed 100 / ml respectively, and Staphylococcus aureus and Pseudomonas aeruginosa should not be detected.

7. The method for preparing the rivano wet compress for skin damage in dermatology according to claim 6, characterized in that: The content determination includes the following contents: Take 3 bags of packaged 0.1% rivanol dressing, open them and dehydrate the adsorbed rivanol solution into a dry and clean 100ml beaker, accurately measure 5ml of this product, put it in a 50ml volumetric flask, add fresh purified water to the scale, shake well, accurately measure 10ml of the diluent, add 0.5g of mannitol, warm until dissolved, quickly cool to room temperature, add 1 drop of phenolphthalein indicator solution, and use sodium hydroxide titration solution (0.1mol / L) until pink appears. The content determination results of 3 batches of samples are obtained, and each 1ml of sodium hydroxide titration solution (0.1mol / L) is equivalent to 6.183mg of HBO.

8. The method for preparing the rivano wet compress for skin damage in dermatology according to claim 1, characterized in that: The method of using the 0.1% rivano dressing is as follows: Take out 0.1% rivanol dressing and apply it closely to the affected skin, replace with a new one after 10-15 minutes, and replace 2-3 pieces in a row (about 1 hour), 2 times a day, until the skin lesions are completely dry and no exudates, or as directed by the doctor.

9. The method for preparing the rivano wet compress for skin damage in dermatology according to claim 8, characterized in that: The 0.1% rivanol dressing can be used after being heated or refrigerated according to the ambient temperature and the patient's condition.

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