Traditional Chinese medicine and crunchy candy for treating qi failing to control blood type hypermenorrhea
By using specific combinations of traditional Chinese medicine prescriptions or sugar, the treatment strategies of replenishing blood and warming the internal and dispelling cold are adopted to solve the problems of long-term treatment and instability of drug efficacy in existing treatment methods, and effective symptom improvement and low recurrence rate are achieved.
Patent Information
- Application Number
- CN202411979058.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-31
- Publication Date
- 2025-03-14
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Treatment methods with excessive menstrual volume of Qi-free blood ingestion type have problems such as long treatment cycle, unstable efficacy and obvious side effects of Western medicine.
Use traditional Chinese medicine prescriptions or crisp sugars composed of Chinese medicines such as Angelica sinensis, Rehmannia glutinosa, White Peony, Chuanxiong, Dried Longan, Shengma, Dried Ginger, Cinnamon and Cinnamon twig to improve the symptoms of high menstrual flow by replenishing blood and warming the internal and dispelling cold.
This method can effectively improve symptoms such as menstrual flow, anemia and fatigue, shorten the treatment cycle, reduce the recurrence rate, and reduce the side effects of the drug.
Abstract
Description
Technical Field
[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine and crispy candy for treating excessive menstrual flow of qi-deficient blood type. Background Art
[0002] Excessive menstrual flow is a disease with menstrual flow significantly more than normal menstrual flow as the main symptom. The range of normal menstrual flow is 30-50 ml. Less than 20 ml is too little menstrual flow, and more than 80 ml is too much menstrual flow. The causes of this disease are deficiency, blood stasis, and heat. If it is deficient, the menstrual blood will lose control, if it is stasis, the menstrual blood will not return to normal and will leave the menstrual period, and if it is hot, the menstrual blood will flow indiscriminately. Common clinical syndromes include: internal disturbance of blood heat, qi failure to control blood, kidney yang deficiency, kidney yin deficiency, and blood stasis in the uterus. The symptoms of qi failure to control blood are mainly manifested as: excessive menstrual flow, or dripping and unclean, light color and thin texture, fatigue and laziness, sallow complexion, shortness of breath when moving, dizziness and palpitations, poor appetite and loose stools, pale and fat tongue or teeth marks on the edges, thin and moist tongue coating, and thin or weak pulse. The weakened warming function of Qi deficiency may cause symptoms of cold body, further affecting the circulation of Qi and blood. In addition to heavy menstrual flow, symptoms such as chills, cold hands and feet, and cold pain in the abdomen may also occur.
[0003] There are many treatment methods for the symptoms of heavy menstrual flow in the Qi-inability blood type. Western medicine uses antifibrinolytic drugs, such as tranexamic acid and mefenamic acid, but they can cause some side effects, such as endocrine disorders, weight gain, etc., and are prone to relapse after stopping the drug. In clinical practice, Chinese medicine often uses the method of "replenishing qi" for treatment, and commonly uses Chinese medicine prescriptions such as Juyuanjian plus or minus, such as ginseng, astragalus, cimicifuga, and white atractylodes to replenish qi, retain blood, and consolidate Chong and Ren meridians, but there are problems such as long treatment cycles and unstable drug efficacy. Summary of the invention
[0004] In order to solve the above technical problems, the first purpose of the present invention is to provide a traditional Chinese medicine for treating excessive menstrual flow due to qi deficiency and blood deficiency, and the second purpose is to provide crispy candy for treating excessive menstrual flow due to qi deficiency and blood deficiency.
[0005] In order to achieve the above-mentioned first purpose, the technical solution of the present invention is: a traditional Chinese medicine for treating excessive menstrual flow due to qi deficiency and blood deficiency, characterized in that it is made of the following raw materials in parts by weight: 25-40 parts of angelica sinensis, 25-40 parts of rehmannia root, 30-45 parts of white peony root, 30-45 parts of chuanxiong, 70-90 parts of jujube, 70-90 parts of dried longan, 10-20 parts of cimicifuga, 10-20 parts of dried ginger, 10-15 parts of cinnamon bark, and 10-15 parts of cassia twig.
[0006] The second object of the present invention is achieved in this way: a crisp candy for treating excessive menstrual flow due to qi deficiency and blood deficiency, characterized in that it is made from ointment prepared from traditional Chinese medicine, red beans, coix seeds, yam, fried rice and brown sugar.
[0007] In the above scheme, the ointment is prepared as follows: angelica, rehmannia root, white peony root, chuanxiong, cimicifuga, dried ginger, cinnamon bark, and cassia twig are ground into powder, soaked in 1.5-2.5 times the weight of anhydrous ethanol for two hours, filtered with cotton, the filter residue is soaked in 1-2 times the weight of anhydrous ethanol for half an hour, filtered with cotton, the filter residue is stored for later use, the filtrate is combined and filtered with filter paper, and the treated filtrate solvent is dried for later use.
[0008] Wash the red dates and dried longan, add the above-mentioned residue, add 10-12 times the weight of water, boil over high heat, then adjust to low heat to make it in a slightly boiling state and cook for 1-1.5 hours, filter the cooked Chinese medicine aqueous solution through gauze, let the filtrate stand, put the residue in a pot again, add water and repeat the boiling and filtering 2-3 times, the boiling time of the residue is 0.5-1h, combine the filtrate, refrigerate and let the filtrate stand, then filter through gauze, concentrate the filtrate to obtain a concentrate, combine the above-mentioned rotary evaporation extract to obtain a paste. Weigh brown sugar, add water to heat and melt the brown sugar until it is slightly thick, pour it into the paste and stir evenly, after cooling, add peppermint essential oil and stir for two hours to obtain the ointment.
[0009] In the above scheme, the preparation method of the crispy candy is: stir-fry red beans, coix seeds and yam for 15-17 minutes, grind them into powder in a grinder at a mass ratio of 1:1:1, sieve for later use, weigh the above-mentioned mixed powder and fried rice for later use, weigh the ointment and brown sugar, and add a little pure water, heat until dense small bubbles appear and stop heating, pour the mixed powder and fried rice into the heated ointment and stir evenly, pour it into a mold while hot, press into shape, cut into pieces, and package to obtain the crispy candy.
[0010] In the above scheme, during the preparation of the ointment, the mass ratio of the ointment to the peppermint essential oil is 157-185:0.01-0.02, and the mass ratio of the ointment to the brown sugar is 157-185:160-180.
[0011] In the above scheme, during the preparation of the crispy candy, the mass ratio of ointment: brown sugar: mixed powder: fried rice is 170-190: 120-155: 220-300: 220-300.
[0012] In the above scheme, during the preparation of the ointment, gauze filtration is first performed using 8-10 layers of gauze for suction filtration, the filtrate is refrigerated and stationary for more than 24 hours, and then filtered using 12-14 layers of gauze.
[0013] In the medicine of the present invention:
[0014] Angelica sinensis has the effects of nourishing blood, regulating menstruation and relieving pain, and moistening the intestines and promoting bowel movements. It tastes sweet and spicy, is warm in nature, and enters the liver, heart, and spleen meridians. Its chemical components mainly include volatile oils (including phthalide lactones), organic acids, polysaccharides, amino acids, and nucleosides. Among them, the active ingredients ferulic acid, angelica polysaccharides, and ligustilide can effectively inhibit inflammatory reactions, inhibit the degradation of extracellular matrix, regulate the metabolism of chondrocytes, and hinder the apoptosis of chondrocytes. It has pharmacological effects such as anti-inflammatory and analgesic, anti-tumor, antioxidant, and immunomodulatory.
[0015] Rehmannia root has the effects of nourishing yin and blood, and tastes sweet and slightly warm. It enters the liver and kidney meridians. Its chemical components mainly include catalpol, rehmannia root, mannitol, vitamin A substances, sugars and amino acids. Among them, the active ingredients catalpol and polysaccharides have the effects of lowering blood sugar and diuresis, and can enhance the body's immune function. It has the effects of nourishing yin and blood, replenishing essence and filling marrow, and is used for liver and kidney yin deficiency, soreness of waist and knees, night sweats and spermatorrhea.
[0016] White peony root has the effects of nourishing blood and regulating menstruation, restraining yin and stopping sweating, softening liver and relieving pain, and calming liver yang. It tastes bitter and sour, is slightly cold in nature, and enters the liver and spleen meridians. The main chemical components are monoterpene glycosides such as paeoniflorin, hydroxypeoniflorin, paeoniflorin lactone glycoside, benzoylpeoniflorin, etc. It also contains peony phenol, tannin, volatile oil, fatty oil, resin, sugar, starch, etc. It has pharmacological effects such as regulating immunity, anti-inflammatory, analgesic, improving intestinal function, and anti-osteoporosis.
[0017] Chuanxiong has the effects of promoting qi and relieving depression, removing wind and dampness, promoting blood circulation and relieving pain. It is pungent in taste and warm in nature, and enters the liver and gallbladder meridians. The main chemical components include alkaloids, volatile oils, phenols and organic acids. Among them, the active ingredient ligustrazine (alkaloids) has the effects of dilating blood vessels and resisting platelet aggregation; ferulic acid (phenols) has the effects of anti-oxidation and scavenging free radicals, which can reduce the damage of oxidative stress to cells, and it also has a bidirectional regulatory effect on uterine smooth muscle, which can play a regulatory role in abnormal uterine contractions such as dysmenorrhea. It is used for irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain, chest and flank pain, swelling and pain due to falls, headache, and rheumatic pain.
[0018] Jujube has the effects of nourishing the spleen and stomach, replenishing qi and promoting the production of body fluid, and alleviating the toxicity of drugs. It is sweet in taste and warm in nature, and enters the spleen, stomach, and heart meridians. The main chemical components are sugars, such as glucose, fructose, and sucrose, as well as proteins, fats, vitamins, and minerals. Among them, the active ingredients polysaccharides, triterpenoids, and flavonoids have anti-inflammatory, anti-allergic, antioxidant, immunomodulatory, and cardiovascular protective effects.
[0019] Dried longan has the effects of nourishing the heart and spleen, nourishing blood and calming the mind. It tastes sweet, is mild and warm in nature, and enters the heart and spleen meridians. The main chemical components include sugars, amino acids, proteins, and lipids. Among them, the active ingredients polysaccharides and adenosine have antioxidant and anti-arrhythmic effects and can enhance immune function. It is often used for insufficient qi and blood, palpitations, forgetfulness and insomnia, and blood deficiency and sallow complexion.
[0020] Cimicifuga has the effects of dispelling heat, clearing away heat and detoxifying, and raising yang and lifting sunken. It tastes spicy and sweet, and is slightly cold in nature. It enters the lung, spleen, large intestine, and stomach meridians. Its main chemical components include triterpenes, phenolic acids, flavonoids, etc. Among them, the active ingredients are mainly triterpenoid compounds, which can resist inflammation and reduce inflammatory reactions; relieve fever and help reduce fever; have inhibitory effects on some viruses and bacteria, and help resist pathogens. It is used for seasonal epidemics, headaches, colds and fever, sore throats, mouth sores, macules that do not clear up; sinking of the middle qi, long-term diarrhea and dysentery, prolapse of the anus, metrorrhagia and leucorrhea in women, and prolapse of the uterus; carbuncle, swelling, and ulcers.
[0021] Dried ginger has the effects of warming the middle and dispelling cold, restoring yang and unblocking meridians, warming the lungs and transforming phlegm. It tastes spicy and is hot in nature. It enters the spleen, stomach, kidney, heart and lung meridians. The main chemical components are volatile oils, gingerols, etc. Volatile oils have anti-inflammatory effects and can reduce inflammatory reactions; they can also promote gastrointestinal motility, help digestion, and relieve gastrointestinal discomfort. Gingerols can promote blood circulation, have a certain effect of dispelling cold and keeping warm, and are also effective in stopping vomiting, which can relieve symptoms of nausea and vomiting. It is mainly used to treat cold pain in the abdomen, vomiting and diarrhea, cold limbs and weak pulse, and cough due to cold phlegm.
[0022] Cinnamon bark has the effects of replenishing fire and supporting yang, guiding fire back to the origin, dispersing cold and relieving pain, and warming and unblocking the meridians. It tastes spicy and sweet, and is very hot in nature. It enters the kidney, spleen, heart, and liver meridians. The main chemical components of cinnamon bark include volatile oils, polysaccharides, polyphenols, flavonoids, etc. Volatile oils are the main active ingredients, among which cinnamaldehyde and other ingredients have the effects of antibacterial, anti-inflammatory, antioxidant, regulating blood sugar, and promoting gastrointestinal motility. It is used for impotence, cold uterus, cold pain in the waist and knees, asthma due to kidney deficiency, floating of virtual yang, dizziness and red eyes, cold pain in the heart and abdomen, vomiting and diarrhea due to deficiency and cold, abdominal pain due to cold hernia, dysmenorrhea and amenorrhea.
[0023] Cinnamon twig has the effects of sweating, warming and unblocking meridians, and warming and supporting Yang Qi. It tastes spicy and hot. It enters the lung, heart, and bladder meridians. The main chemical components include volatile oils, organic acids, polysaccharides, etc. Volatile oil is the main active ingredient of cinnamon twig, and its composition and efficacy are similar to cinnamon bark. Organic acids and other ingredients in cinnamon twig can play a role in dilating blood vessels, thereby promoting blood circulation and helping the body to dispel cold evil. It is used for colds, cold blood stagnation and pain, phlegm and fluid retention, water retention syndrome, and palpitations.
[0024] In clinical practice, Chinese medicine mostly treats excessive menstrual flow due to the inability of Qi to retain blood by "tonifying Qi". The commonly used Chinese medicine prescription is Yuan Jian with modifications, such as ginseng, astragalus, cimicifuga, atractylodes, etc., which can replenish Qi, retain blood, and consolidate Chong and Ren meridians. However, there are problems such as long treatment cycle and unstable efficacy.
[0025] The present invention adopts the treatment strategy of "replenishing blood". Blood is the mother of Qi. The fullness and function of Qi are inseparable from the nourishment of blood. If the blood is sufficient, the Qi is strong, and if the blood is deficient, the Qi is insufficient. Nourishing Qi by "replenishing blood" can not only improve the symptoms of heavy menstrual flow, but also regulate symptoms such as anemia and fatigue caused by heavy bleeding, treating both the symptoms and the root cause.
[0026] The medicine formula of the invention reuses Siwu decoction (Danggui, Chuanxiong, White Peony Root and Rehmannia Glutinosa) to nourish blood and regulate blood, and is supplemented with Chinese medicine for warming the interior and dispersing cold, and has a good effect on treating the symptoms of excessive menstrual flow due to qi failure to control blood type, and has a short medication cycle and is not prone to recurrence.
[0027] The advantages of various medicinal flavors in the present invention are complementary, and the drugs are used together to give full play to the synergistic effect of the various drugs, so that the multiple active ingredients of the product work together to achieve the purpose of treating the symptoms of excessive menstrual flow in the qi-deficient blood type through multiple pathways.
[0028] Since Chinese medicine decoctions have strong odors and bitter tastes, the boiling process takes a long time and the patient compliance is poor, the present invention combines modern food production technology to produce an efficient, portable, and highly compliant Chinese medicine crisp candy health food. The product has a good taste and only needs to be consumed in small amounts every day, which can improve the utilization efficiency of Chinese medicine pieces, greatly save Chinese medicine resources, and reduce the economic burden on patients. DETAILED DESCRIPTION
[0029] The present invention will be further described below in conjunction with the embodiments.
[0030] Example 1
[0031] A Chinese medicine for treating excessive menstrual flow due to qi-deficient blood type is prepared from 25g of angelica, 40g of Rehmannia glutinosa, 30g of white peony root, 45g of Chuanxiong, 70g of jujube, 90g of dried longan, 10g of Cimicifuga heracleifolia, 10g of dried ginger, 15g of cinnamon bark, and 15g of cassia twig. Add 2L of water to the above Chinese medicine and boil it on low heat until 1L is obtained, filter it, boil the residue repeatedly once, combine the filtrate, and prepare a total of 2L of Chinese medicine decoction, which is consumed for 5 days, once in the morning and once in the evening every day.
[0032] Example 2
[0033] A Chinese medicine for treating excessive menstrual flow due to qi-deficient blood type is prepared from 40g of angelica, 25g of Rehmannia glutinosa, 45g of white peony root, 90g of jujube, 70g of dried longan, 30g of Chuanxiong, 20g of Cimicifuga heracleifolia, 20g of dried ginger, 10g of cinnamon bark, and 10g of cassia twig. Add 2L of water to the above Chinese medicine and boil it on low heat for 1L, filter it, boil the residue repeatedly for 1 time, combine the filtrate, and make a total of 2L of Chinese medicine decoction, which is taken for 5 days, once in the morning and once in the evening every day.
[0034] Example 3: Traditional Chinese medicine crispy candy for treating excessive menstrual flow due to qi deficiency and blood deficiency, comprising 25g of angelica sinensis, 40g of rehmannia root, 30g of white peony root, 45g of chuanxiong, 70g of jujube, 90g of dried longan, 10g of cimicifuga heracleifolia, 10g of dried ginger, 15g of cinnamon bark, and 15g of cassia twig.
[0035] (1) Preparation of ointment
[0036] Powder angelica, Rehmannia root, white peony root, Chuanxiong, Cimicifuga, dried ginger, cinnamon bark, and cassia twig, soak them in 1.5 times the weight of anhydrous ethanol for two hours, filter with cotton, soak the residue in 1 times the weight of anhydrous ethanol for half an hour, filter with cotton, save the residue for later use, combine the filtrates and filter with filter paper once. Rotary evaporate the treated filtrate, and keep the temperature at 70℃ for half an hour when it is almost dry, to obtain 17g of extract.
[0037] Red dates and longan are cleaned, and the above-mentioned filter residue is added, and the water of 10 times of weight is boiled over high heat and then adjusted to low heat to make it in a micro-boiling state and boil for 1-1.5h, and the boiled Chinese medicine water is filtered through 8 layers of gauze, and the filtrate is left to stand, and the filter residue is placed in a pot again, and water is added to repeat boiling and filtering 2-3 times, and the filter residue boiling time is 0.5-1h, and the filtrate is combined, and the filtrate is refrigerated and left to stand for more than 24 hours, and then filtered with 12 layers of gauze, and the filtrate is concentrated to the state of picking up with chopsticks and dripping with silk under power 600w with an electric ceramic stove, but the state of not hanging paint is obtained. Concentrate (now also contains some moisture), merged with the above-mentioned rotary evaporation extract to obtain paste A 174g. Weigh brown sugar 162g, add a certain amount of water and heat brown sugar to concentrate to viscosity, pour into 157g paste A and stir. After cooling, add peppermint essential oil 0.015g and stir for two hours to obtain ointment I 360g.
[0038] (2) Preparation of crispy candy
[0039] Stir-fry red beans, coix seeds and yam for 15 minutes with a ceramic stove at 400W, grind them into powder in a grinder at a mass ratio of 1:1:1, and sieve them with a 50-mesh sieve for later use. Weigh 240g of the above mixed powder and 300g of fried rice for later use. Weigh 180g of ointment, 120g of brown sugar, and add a little purified water. Heat with a ceramic stove at 400W until dense bubbles appear, then stop heating. Pour the mixed powder and fried rice into the heated ointment and stir evenly. Pour it into the mold while hot, press it into shape, cut it into pieces, and package it to obtain 40 pieces of Chinese medicine health food crispy candy, each piece weighing about 21g, equivalent to 4.4g of Chinese medicine slices.
[0040] Example 4: Traditional Chinese medicine crispy candy for treating excessive menstrual flow due to qi deficiency and blood deficiency, comprising 40g of angelica sinensis, 25g of rehmannia root, 45g of white peony root, 90g of jujube, 70g of dried longan, 30g of chuanxiong, 20g of cimicifuga heracleifolia, 20g of dried ginger, 10g of cinnamon bark, and 10g of cassia twig.
[0041] (1) Preparation of ointment
[0042] Powder angelica, Radix Rehmanniae Preparata, Radix Paeoniae Alba, Rhizoma Chuanxiong, Rhizoma Cimicifugae, Rhizoma Zingiberis, Rhizoma Cimicifugae, Rhizoma Cinnamomi, and Rhizoma Cinnamomi into powder, soak them in 2.5 times the weight of anhydrous ethanol for two hours, filter them with cotton, soak the residue in 2 times the weight of anhydrous ethanol for half an hour, filter them with cotton (save the residue), combine the filtrates and filter them with filter paper once. Rotate the treated filtrate, and keep the temperature at 70°C for half an hour until it is almost dry, and obtain 18g of extract. Wash red dates and longan, add the above-mentioned filter residue, add 12 times the weight of water, boil over high heat, then adjust to low heat to make it in a slightly boiling state and cook for 1-1.5h, filter the cooked Chinese medicine water through gauze, let the filtrate stand, put the filter residue in a pot again, add water and repeat boiling and filtering 2-3 times, the filter residue boiling time is 0.5-1h, merge the filtrate, refrigerate the filtrate and let it stand for more than 24 hours, then filter it with 14 layers of gauze, concentrate the filtrate with an electric ceramic stove at a power of 600w until it drips with silk when picked up with chopsticks, but does not hang paint, and obtain a concentrate, and combine the above-mentioned rotary evaporation extract to obtain 178g of paste B. Weigh 180g of brown sugar, add a certain amount of water to heat and concentrate the brown sugar to viscosity, pour it into paste B and stir evenly. After cooling, add 0.02g of peppermint essential oil and stir for two hours to obtain 375g of ointment II.
[0043] (2) Preparation of crispy candy
[0044] Stir-fry red beans, coix seeds and yam for 17 minutes at a power of 400w in an electric ceramic stove, grind them into powder in a pulverizer at a mass ratio of 1:1:1, and sieve them with a 50-mesh sieve for later use. Weigh 300g of the above mixed powder and 200g of fried rice for later use. Weigh 185g of ointment II and 150g of brown sugar, add a little purified water, heat with an electric ceramic stove at 400w until dense bubbles appear, stop heating, pour the mixed powder and fried rice into the heated ointment and stir evenly. Pour it into the mold while hot, press it into shape, cut it into pieces and package it appropriately to obtain 40 pieces of Chinese medicine health food crispy candy, each piece weighing about 21g, equivalent to 4.4g of Chinese medicine slices.
[0045] The beneficial effects of the present invention are further described below through test examples:
[0046] 1. Evaluation of clinical efficacy in patients with excessive menstrual flow due to qi-deficient blood retention
[0047] 105 patients with excessive menstrual flow due to qi-deficient blood type, accompanied by symptoms such as chills, cold hands and feet, and cold pain in the abdomen, aged 20 to 50 years old, were selected and randomly divided into 5 groups, namely, Example 1 Group, Example 2 Group, Example 3 Group, Example 4 Group, and Western medicine control group.
[0048] The Example 1 group and the Example 2 group took Chinese medicine, each medicine can be taken for 5 days, once in the morning and once in the evening, starting from the end of menstruation until the next menstruation, stopping during menstruation, and taking continuously for 2 months.
[0049] The patients in Example 3 and Example 4 groups took the crisp candies of Examples 3 and 4, 2 pieces each time, 1 hour after breakfast and dinner, and avoided drinking water within 30 minutes after taking them. They started taking them after the end of menstruation and continued to take them until the next menstruation came. They stopped taking them during the menstrual period for 2 consecutive months.
[0050] The control group took tranexamic acid tablets, starting from the second day of menstruation, twice a day, 0.25g each time, for 2-3 days until the menstrual volume decreased significantly and then stopped.
[0051] There were no significant differences in symptoms, gender, age, and course of disease among the groups of cases.
[0052] Efficacy evaluation criteria
[0053] Total effective rate = (number of cured cases + markedly effective cases + effective cases) / total number of cases × 100%.
[0054] result
[0055] 1 Comparison of clinical efficacy: The total effective rates of Example 1, Example 2, Example 3, Example 4 and the control group were 95.2%, 90.4%, 95.2% and 95.2%, respectively, while the total effective rate of the positive control Western medicine treatment was 81%, and the efficacy of the Chinese medicine composition group of Examples 1 to 4 and the crispy candy group was significantly better than that of the Western medicine control group.
[0056] Relapse: The drug was discontinued after 2 months of use, and the relapse was observed from the third menstrual period. The total relapse rates of Example 1, Example 2, Example 3, Example 4 and the control group were 4.7%, 9.5%, 14.2% and 14.2%, respectively, while the total relapse rate of the positive control Western medicine treatment was 81%. The relapse rates of the Chinese medicine composition groups of Examples 1 to 4 and the crispy candy group were significantly lower than those of the Western medicine control group.
[0057] Toxic and side effects: No obvious adverse reactions or obvious toxic and side effects occurred in the cases of the Chinese medicine composition treatment group of Examples 1 to 4 and the Western medicine control treatment group before and after treatment.
[0058] Typical application examples
[0059] Gong: Female, 20 years old, cycle of about 28 days, regular cycle, menstruation lasts 5-7 days, menstrual volume is about twice that of normal people around, the volume is large on the second day of the menstrual period, and the menstruation is like a stream. There are certain symptoms of body cold, cold hands and feet in autumn and winter, severe pain two days before menstruation, need to keep warm, prone to sweating during physiological period and at other times, relatively weak during and after menstruation, and weak body. Using the crispy candy in Example 3 for 30 days, the duration of the menstrual period is shortened to four days, the menstrual volume on the second day is halved, in addition, menstrual sweating is also alleviated, and fatigue after menstruation is improved.
[0060] Lei: female, 22 years old, menstrual period lasts 5 days, cycle is about 30 days, slight pain on the first day of menstruation, heavy flow on the second and third days, backache and fatigue during the period, usually with body cold symptoms, body coldness aggravated in winter, usually with mild fatigue and soreness. After using the crispy candy in Example 3 for 30 days, the menstrual flow on the second and third days was significantly reduced, the duration of the menstrual period did not change, and the backache and fatigue during the menstrual period were improved.
[0061] 2. Internal disturbance of blood heat, deficiency of kidney yang, deficiency of kidney yin and stasis of uterus
[0062] 25 patients aged 20 to 50 years old with internal disturbance of blood heat, deficiency of kidney yang, deficiency of kidney yin and uterine stasis were selected and randomly assigned to take the crisp candies of Examples 3 and 4. After 2 months, the total effective rates were 20%, 52%, 44% and 24%, respectively.
[0063] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. A Chinese medicine for treating excessive menstrual flow due to qi deficiency and blood deficiency, characterized in that: The invention is prepared from the following raw materials in parts by weight: 25-40 parts of angelica sinensis, 25-40 parts of rehmannia root, 30-45 parts of white peony root, 30-45 parts of ligusticum chuanxiong, 70-90 parts of jujube, 70-90 parts of dried longan, 10-20 parts of cimicifuga heracleifolia, 10-20 parts of dried ginger, 10-15 parts of cinnamon bark and 10-15 parts of cassia twig.
2. A crispy candy for treating excessive menstrual flow due to qi deficiency and blood deficiency, characterized in that: The ointment is prepared from the traditional Chinese medicine according to claim 1, red beans, coix seeds, yam, fried rice and brown sugar.
3. The crispy candy for treating excessive menstrual flow due to lack of blood according to claim 1, characterized in that: The ointment is prepared by: grinding angelica, Rehmannia root, white peony root, Chuanxiong, Cimicifuga, dried ginger, cinnamon bark and cassia twig into powder, soaking them in 1.5-2.5 times the weight of anhydrous ethanol for two hours, filtering with cotton, soaking the residue in 1-2 times the weight of anhydrous ethanol for half an hour, filtering with cotton, saving the residue for later use, combining the filtrates and filtering with filter paper, and drying the treated filtrate solvent for later use; Wash the red dates and dried longan, add the above-mentioned residue, add 10-12 times the weight of water, boil over high heat, then adjust to low heat to make it in a slightly boiling state and cook for 1-1.5 hours, filter the cooked Chinese medicine aqueous solution through gauze, let the filtrate stand, put the residue in a pot again, add water and repeat the boiling and filtering 2-3 times, the boiling time of the residue is 0.5-1h, combine the filtrate, refrigerate and let the filtrate stand, then filter through gauze, concentrate the filtrate to obtain a concentrate, combine the above-mentioned rotary evaporation extract to obtain a paste. Weigh brown sugar, add water to heat and melt the brown sugar until it is slightly thick, pour it into the paste and stir evenly, after cooling, add peppermint essential oil and stir for two hours to obtain the ointment.
4. The crispy candy for treating excessive menstrual flow due to lack of blood according to claim 3, characterized in that: The preparation method of the crispy candy is as follows: stir-fry red beans, coix seeds and yam for 15-17 minutes, grind them into powder in a grinder at a mass ratio of 1:1:1, sieve and set aside, weigh the above-mentioned mixed powder and fried rice and set aside, weigh the ointment and brown sugar, and add a little pure water, heat until dense small bubbles appear and stop heating, pour the mixed powder and fried rice into the heated ointment and stir evenly, pour it into a mold while hot, press into shape, cut into pieces, and package to obtain the crispy candy.
5. The crispy candy for treating excessive menstrual flow due to lack of blood according to claim 4, characterized in that: During the preparation of the ointment, the mass ratio of the ointment to the peppermint essential oil is 157-185:0.01-0.02, and the mass ratio of the ointment to the brown sugar is 157-185:160-180.
6. The crispy candy for treating excessive menstrual flow due to lack of blood according to claim 5, characterized in that: In the preparation of crispy candy, the mass ratio of ointment: brown sugar: mixed powder: fried rice is 170-190: 120-155: 220-300: 220-300.
7. The crispy candy for treating excessive menstrual flow in patients with qi deficiency and blood deficiency according to any one of claims 2 to 6, characterized in that: During the preparation of the ointment, gauze filtration is first performed using 8-10 layers of gauze for suction filtration, the filtrate is refrigerated and stationary for more than 24 hours, and then filtered using 12-14 layers of gauze.