A burn patch for treating skin wounds and its preparation method

Abstract

The present invention relates to the technical field of burn patches, and particularly to a burn patch for treating skin wounds and a preparation method thereof. The method includes: dissolving the active ingredients and the collagen into a solvent using a stirrer to output a mixed solution; bonding the silica gel with the nylon textile fabric to output a film patch; coating the mixed solution on one side of the nylon textile fabric of the film patch; drying the film patch coated with the mixed solution using a hot air circulation oven; cutting the dried film patch using a cutting machine; punching holes on the silica gel side of the cut film patch to output a burn patch; determining the preparation stability of the burn patch based on the variance of the concentration of the mixed solution; if the preparation stability does not meet the requirements, adjusting the rotation speed of the stirring motor of the stirrer; if the forming effectiveness does not meet the requirements, adjusting the tool feed of the cutting machine. The present invention improves the preparation stability of the burn patch.

Description

Technical Field

[0001] The present invention relates to the technical field of burn patches, and particularly to a burn patch for treating skin wounds and a preparation method thereof. Background Art

[0002] In the prior art, the outermost layer of the human skin is the epidermis of the human body, with a thickness of approximately between 75 and 260 micrometers. Once burned, scalded, or damaged, such as by friction / contact with chemical active ingredients, the human epidermis will peel off, resulting in painful wounds.

[0003] An artificial epidermal substitute membrane is a medical device for treating such wounds. It is a fully synthetic product with only three main components: silicone, nylon textile fabric, and collagen. Its purpose is to temporarily replace the lost epidermis of the human body. First, it makes the human body feel that the epidermis is still there, reducing inflammation. By combining with the wound, it does not need to be replaced during the healing process until it naturally falls off after the wound heals. When combined with a suitable application medical procedure, the artificial epidermal substitute patch can accelerate the healing of the patient's wound. Also, because it replicates the texture and expansibility of human skin, it brings a sense of comfort and reduces pain. After being applied, it does not need to be replaced during the healing process of the wound, unless there are emergency situations such as infection or severe inflammation in the wound, until it falls off by itself when the wound heals. This is different from ordinary treatment courses that require repeated replacement of the cotton / dressings covering the wound. This repeated pulling of the wound will cause slow wound healing and also bring pain. Using a suitable epidermal substitute patch can save the workload of medical staff, allow patients to be discharged earlier, reduce the infection rate of the patient's wound, etc., and ultimately reduce the economic burden of trauma / burns. The overall structure of the artificial epidermal substitute membrane is mostly a three-layer product. It mainly needs to be temporarily combined with the human body, so its thickness, texture, elasticity, stretching / expansibility are similar to those of real human epidermis. The outermost layer is a layer of silicone, whose main function is to control the external contact of the wound to prevent bacterial infection. Under the silicone layer, a nylon textile fabric is combined. The textile is to give the nylon fabric four-way expansion ability and also to bind the serum of the wound, so that the whole dressing adheres to the human body. The nylon filaments are also used to conduct liquids, guiding the liquids of the wound to the holes punched in the silicone, where they overflow / evaporate. A layer of collagen with a concentration of 10 micrograms per square centimeter is sprayed on the nylon textile fabric. This helps the textile fabric react with the serum to achieve rapid blood coagulation, and through blood coagulation on the textile fabric, it achieves wound healing.

[0004] The first approved artificial epidermal substitute membrane on the market was Biobrane (No. 4725279) in 1979. So far, the patent has expired. In 2009, a new generation of product AWBAT (US20090232878A1) emerged, and in 2019, a new product Permeaderm (WO2020231463A1) was launched.

[0005] To date, the 1979 Biobrane has been acquired by Smith & Nephew and is commonly used in countries such as the European Union, the United Kingdom, Singapore, and the United States. Although there is no patent protection, due to the complex production process and the approval batch numbers from the drug regulatory authorities in the European Union, the United States, and Southeast Asia, as well as the mature medical device sales supply chain, there are few counterfeiters other than the developer Aubrey Woodroof to date.

[0006] Chinese Patent Publication No.: CN105617461A discloses a skin patch for treating skin burns and its preparation method, including the following steps: obtaining adipose stem cells and allogeneic skin matrix respectively; mixing the adipose stem cells with a collagen solution and then inoculating them on the allogeneic skin matrix; wherein, the adipose stem cells are derived from the autologous body of the skin burn patient. Thus, the skin patch for treating skin burns and its preparation method have the problem that during the dissolution process of the active ingredient, there is residual accumulation of the active ingredient on the inner wall of the mixing container, resulting in poor liquid flow during mixing, thereby causing a decrease in the preparation stability of the burn patch. Summary of the Invention

[0007] Therefore, the present invention provides a burn patch for treating skin wounds and its preparation method to overcome the problem in the prior art that during the dissolution process of the active ingredient, there is residual accumulation of the active ingredient on the inner wall of the mixing container, resulting in poor liquid flow during mixing, and further causing uneven mixing, thereby leading to a decrease in the preparation stability of the burn patch.

[0008] To achieve the above object, the present invention provides a preparation method of a burn patch for treating skin wounds, including: extracting collagen from fish by a biological small molecule recovery method, using a stirrer to dissolve the active ingredient and the collagen into a solvent to output a mixed solution, bonding silica gel with a nylon textile fabric to output a film patch, and coating the mixed solution on the nylon textile fabric side of the film patch; drying the film patch coated with the mixed solution using a hot air circulation oven, cutting the dried film patch using a cutting machine, punching holes on the silica gel side of the cut film patch to output a burn patch; obtaining the concentrations of the mixed solution at several sampling points; determining the preparation stability of the burn patch based on the variance of the concentration of the mixed solution; if the preparation stability does not meet the requirements, adjusting the rotation speed of the stirring motor of the stirrer, or, determining the forming effectiveness of the burn patch based on the average roughness at the incision of the burn patch; if the forming effectiveness does not meet the requirements, adjusting the tool feed rate of the cutting machine, or, adjusting the air flow circulation speed in the hot air circulation oven based on the drying rate of the burn patch.

[0009] Further, determining the preparation stability of the burn patch includes:

[0010] Compare the variance of the concentration of the mixed solution with a preset first variance;

[0011] If the variance of the concentration of the mixed solution is greater than the preset first variance, it is determined that the preparation stability of the burn dressing does not meet the requirements.

[0012] Furthermore, determining the forming effectiveness of the burn dressing includes:

[0013] Compare the variance of the concentration of the mixed solution with the preset first variance and the preset second variance respectively;

[0014] If the variance of the concentration of the mixed solution is greater than the preset first variance and less than or equal to the preset second variance, it is preliminarily determined that the forming effectiveness of the burn dressing does not meet the requirements, and it is determined whether the forming effectiveness of the burn dressing meets the requirements according to the average roughness at the incision of the burn dressing.

[0015] Furthermore, adjusting the rotational speed of the stirring motor of the stirrer includes:

[0016] Compare the variance of the concentration of the mixed solution with the preset second variance;

[0017] If the variance of the concentration of the mixed solution is greater than the preset second variance, increase the rotational speed of the stirring motor of the stirrer.

[0018] Furthermore, the increase amplitude of the rotational speed of the stirring motor of the stirrer is determined by the difference between the variance of the concentration of the mixed solution and the preset second variance.

[0019] Furthermore, adjusting the tool feed of the cutting machine includes:

[0020] Compare the average roughness at the incision of the burn dressing with a preset first roughness and a preset second roughness respectively;

[0021] If the average roughness at the incision of the burn dressing is greater than the preset first roughness, it is determined that the forming effectiveness of the burn dressing does not meet the requirements;

[0022] If the average roughness at the incision of the burn dressing is greater than the preset first roughness and less than or equal to the preset second roughness, reduce the tool feed of the cutting machine;

[0023] If the average roughness at the incision of the burn dressing is greater than the preset second roughness, it is preliminarily determined that the drying effectiveness of the burn dressing does not meet the requirements, and it is determined whether the drying effectiveness of the burn dressing meets the requirements according to the drying rate of the burn dressing.

[0024] Furthermore, the reduction amplitude of the tool feed of the cutting machine is determined by the difference between the average roughness at the incision of the burn dressing and the preset first roughness.

[0025] Further, adjusting the air flow circulation speed in the hot air circulation oven includes:

[0026] Comparing the drying rate of the burn dressing with a preset drying rate;

[0027] If the drying rate of the burn dressing is less than the preset drying rate, it is determined that the drying effectiveness of the burn dressing does not meet the requirements, and the air flow circulation speed in the hot air circulation oven is increased.

[0028] Further, the increasing amplitude of the air flow circulation speed in the hot air circulation oven is determined by the difference between the preset drying rate and the drying rate of the burn dressing.

[0029] The present invention also provides a burn dressing for treating skin wounds, including: silicone, nylon textile, type I collagen, vitamin C, and glycerol.

[0030] Compared with the prior art, the beneficial effects of the present invention are as follows. The method of the present invention adjusts the rotation speed of the stirring motor of the stirrer according to the variance of the concentration of the mixed solution. During the dissolution process of the active ingredients, there is a residue accumulation of the active ingredients on the inner wall of the mixing container, resulting in poor liquid flow during mixing, and thus uneven mixing. By increasing the rotation speed of the stirring motor of the stirrer, the stirrer can provide a greater driving force to push the liquid to flow more quickly, which helps to overcome the flow resistance caused by the accumulation of residual substances, enables the liquid to circulate more fully in the container, and reduces the uneven mixing area caused by poor flow. Adjust the tool feed rate of the cutting machine according to the average roughness at the incision of the burn dressing. Since the cutting tool used for cutting will wear after long-term use and the cutting edge is no longer sharp, resulting in problems such as unsmooth cutting and rough incisions. By reducing the tool feed rate of the cutting machine, the tool can have a more sufficient contact time with the material during cutting, the depth and force of each cut are relatively small, and the cutting action can be completed more precisely, thereby improving the cutting effect and making the incision smoother. Adjust the air flow circulation speed in the hot air circulation oven according to the drying rate of the burn dressing. Since the heating element in the drying equipment ages, resulting in uneven temperature in the drying equipment and thus uneven drying temperature. By increasing the air flow circulation speed in the hot air circulation oven, the low-temperature area can absorb heat more quickly, narrowing the temperature gap with the high-temperature area, thereby improving the uniformity of the temperature distribution and enhancing the preparation stability of the burn dressing.

[0031] Furthermore, in the method of the present invention, by setting a preset first variance and a preset second variance, the rotational speed of the stirring motor of the stirrer is adjusted. During the dissolution process of the active ingredient, there is a residue accumulation of the active ingredient on the inner wall of the mixing container, resulting in poor liquid flow during mixing, and thus uneven mixing. By increasing the rotational speed of the stirring motor of the stirrer, the stirrer can provide a greater driving force to push the liquid to flow more rapidly, which helps to overcome the flow resistance caused by the accumulation of residual substances, enables the liquid to circulate more fully in the container, reduces the uneven mixing area caused by poor flow, and further improves the preparation stability of the burn dressing.

[0032] Furthermore, in the method of the present invention, by setting a preset first roughness and a preset second roughness, the tool feed rate of the cutting machine is adjusted. Since the tool used for cutting will be worn after long-term use and the cutting edge is no longer sharp, problems such as unsmooth cutting and rough cut surfaces will occur. By reducing the tool feed rate of the cutting machine, the tool can have a more sufficient contact time with the material during cutting, the depth and force of each cut are relatively small, and the cutting action can be completed more precisely, thereby improving the cutting effect, making the cut surface smoother, and further improving the preparation stability of the burn dressing.

[0033] Furthermore, in the method of the present invention, by setting a preset drying rate, the air flow circulation speed in the hot air circulation oven is adjusted. Since the heating element in the drying equipment is aged, the temperature in the drying equipment is uneven, resulting in uneven drying temperature. By increasing the air flow circulation speed in the hot air circulation oven, the low-temperature area can absorb heat more quickly, reducing the temperature difference from the high-temperature area, thereby improving the uniformity of the temperature distribution and further improving the preparation stability of the burn dressing. Description of the Drawings

[0034] Figure 1 It is the overall flowchart of the preparation method of the burn dressing for treating skin wounds in the embodiment of the present invention;

[0035] Figure 2 It is the logical flowchart of the preparation method of the burn dressing for treating skin wounds in the embodiment of the present invention;

[0036] Figure 3 It is the specific flowchart of the process of adjusting the rotational speed of the stirring motor of the stirrer in the preparation method of the burn dressing for treating skin wounds in the embodiment of the present invention;

[0037] Figure 4 It is the specific flowchart of the process of adjusting the tool feed rate of the cutting machine in the preparation method of the burn dressing for treating skin wounds in the embodiment of the present invention. Detailed Embodiments

[0038] To make the objectives and advantages of the present invention more clear and understandable, the present invention will be further described below in conjunction with embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0039] The preferred embodiments of the present invention will be described below with reference to the accompanying drawings. Those skilled in the art should understand that these embodiments are only used to explain the technical principles of the present invention and do not limit the protection scope of the present invention.

[0040] It should be noted that in the description of the present invention, the terms indicating the direction or positional relationship such as "upper", "lower", "left", "right", "inner", "outer", etc. are based on the direction or positional relationship shown in the drawings. This is only for convenience of description and does not indicate or imply that the device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present invention.

[0041] In addition, it should also be noted that in the description of the present invention, unless otherwise clearly specified and limited, the terms "installation", "connection", and "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two elements. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0042] Please refer to Figure 1 、 Figure 2 、 Figure 3 and Figure 4 as shown, which are respectively the overall flowchart, the logical flowchart, the specific flowchart of the process for adjusting the rotational speed of the stirring motor of the stirrer, and the specific flowchart of the process for adjusting the tool feed of the cutting machine of the burn dressing and its preparation method for treating skin wounds in the embodiments of the present invention. A preparation method of a burn dressing for treating skin wounds of the present invention includes:

[0043] Step S1, extracting collagen from fish by the biological small molecule recovery method, using a stirrer to dissolve the active ingredients and the collagen into a solvent to output a mixed solution, bonding silica gel and nylon textile fabric to output a film patch, and coating the mixed solution on the nylon textile fabric side of the film patch;

[0044] Step S2, drying the film patch coated with the mixed solution using a hot air circulation oven, cutting the dried film patch using a cutting machine, and punching holes on the silica gel side of the cut film patch to output a burn dressing;

[0045] Step S3, obtain the concentrations of the mixed solutions at several sampling points;

[0046] Step S4, determine the preparation stability of the burn dressing based on the variance of the concentrations of the mixed solutions;

[0047] Step S5, if the preparation stability does not meet the requirements, adjust the rotational speed of the stirring motor of the stirrer, or determine the forming effectiveness of the burn dressing based on the average roughness at the incision of the burn dressing;

[0048] Step S6, if the forming effectiveness does not meet the requirements, adjust the tool feed of the cutting machine, or adjust the air flow circulation speed in the hot air circulation oven based on the drying rate of the burn dressing.

[0049] Specifically, the biological small molecule recovery method is as follows: pulverize the swim bladders, fish maws, and fish skins of fish to output extraction raw materials, use an ethanol solvent to extract the extraction raw materials to output an extraction solution, perform filtration, centrifugation, and extraction operations on the extraction solution in sequence to output a purified solution, and perform distillation and drying treatments on the purified solution in sequence to output collagen powder.

[0050] Specifically, the extraction sites of collagen include the swim bladders of fish, the fish maws of fish, and the fish skins of fish.

[0051] Specifically, the active ingredients include silver sulfadiazine, vitamin C, and hydrocortisone.

[0052] Specifically, the solvents include water, ethanol, and propylene glycol.

[0053] Specifically, the mixed solution includes silver sulfadiazine, water, and sodium carboxymethylcellulose.

[0054] Specifically, the shapes of the punched holes include circular, diamond-shaped, square, +-shaped, and X-shaped.

[0055] Specifically, only the silica gel layer is punched.

[0056] Specifically, during the stretching process, the holes will become smaller after being stretched horizontally.

[0057] Specifically, the detection method for the concentration of the mixed solution is as follows: divide the mixed solution into several equal-mass portions of solution, inject the several portions of solution into a high-performance liquid chromatograph for analysis, and calculate the concentrations of each component in the several portions of solution respectively by comparing with a standard product with a known concentration.

[0058] Specifically, the tool feed of the cutting machine is the distance that the tool of the cutting machine advances during each cutting stroke.

[0059] In implementation, the method of the present invention adjusts the rotational speed of the stirring motor of the stirrer according to the variance of the concentration of the mixed solution. During the dissolution process of the active ingredient, there is residual accumulation of the active ingredient on the inner wall of the mixing container, resulting in poor liquid flow during mixing, and thus uneven mixing. By increasing the rotational speed of the stirring motor of the stirrer, the stirrer can provide a greater driving force to push the liquid to flow more rapidly, which helps to overcome the flow resistance caused by the accumulation of residual substances, enables the liquid to circulate more fully in the container, and reduces the uneven mixing area caused by poor flow. Adjust the tool feed rate of the cutting machine according to the average roughness at the incision of the burn dressing. Since the tool used for cutting will be worn after long-term use and the cutting edge is no longer sharp, problems such as unsmooth cutting and rough incisions will occur. By reducing the tool feed rate of the cutting machine, the tool can have a more sufficient contact time with the material during cutting, the depth and force of each cut are relatively small, and the cutting action can be completed more precisely, thereby improving the cutting effect and making the incision smoother. Adjust the air flow circulation speed in the hot air circulation oven according to the drying rate of the burn dressing. Since the heating element in the drying equipment is aged, the temperature in the drying equipment is uneven, resulting in uneven drying temperature. By increasing the air flow circulation speed in the hot air circulation oven, the low-temperature area can absorb heat more quickly, reducing the temperature difference from the high-temperature area, thereby improving the uniformity of the temperature distribution and enhancing the preparation stability of the burn dressing.

[0060] Specifically, determining the preparation stability of the burn dressing includes:

[0061] Obtain the concentrations of the mixed solution at several sampling points and calculate the variance of the concentration of the mixed solution;

[0062] Compare the variance of the concentration of the mixed solution with a preset first variance;

[0063] If the variance of the concentration of the mixed solution is greater than the preset first variance, it is determined that the preparation stability of the burn dressing does not meet the requirements.

[0064] Specifically, determining the forming effectiveness of the burn dressing includes:

[0065] Compare the variance of the concentration of the mixed solution with the preset first variance and the preset second variance respectively;

[0066] If the variance of the concentration of the mixed solution is greater than the preset first variance and less than or equal to the preset second variance, it is preliminarily determined that the forming effectiveness of the burn dressing does not meet the requirements, and it is determined whether the forming effectiveness of the burn dressing meets the requirements according to the average roughness at the incision of the burn dressing.

[0067] It can be understood that the three intervals divided by the preset first variance and the preset second variance respectively correspond to three situations:

[0068] The first interval is that the variance of the concentration of the mixed solution is less than or equal to the preset first variance, and the corresponding situation is: it is determined that the preparation stability of the burn dressing meets the requirements;

[0069] The second interval is that the variance of the concentration of the mixed solution is greater than the preset first variance and less than or equal to the preset second variance, and the corresponding situation is: due to the wear of the cutting tool after long-term use, the cutting edge is no longer sharp, resulting in problems such as unsmooth cutting and rough cut surfaces;

[0070] The third interval is that the variance of the concentration of the mixed solution is greater than the preset second variance, and the corresponding situation is: due to the accumulation of residual active ingredients on the inner wall of the mixing container during the dissolution process of the active ingredients, the liquid flow is not smooth during mixing, resulting in uneven mixing.

[0071] In practice, the generally selected range of the preset first variance is [0.5 (mol / L) 2 , 1.5 (mol / L) 2 , and the generally selected range of the preset second variance is [2 (mol / L) 2 , 3 (mol / L) 2 .

[0072] Preferably, the preferred embodiment of the preset first variance is 1 (mol / L) 2 , and the generally selected range of the preset second variance is 2.5 (mol / L) 2 .

[0073] Specifically, the variance of the concentration of the mixed solution is the variance of the concentration of the mixed solution at several sampling points. The calculation method of the variance of the concentration of the mixed solution is a conventional technical means well-known to those skilled in the art. Therefore, the calculation process of the variance of the concentration of the mixed solution will not be elaborated here.

[0074] In implementation, the method of the present invention determines the preparation stability of the burn dressing by setting the preset first variance and the preset second variance, reducing the impact of the inaccurate determination of the preparation stability of the burn dressing on the preparation accuracy of the burn dressing, and further improving the preparation stability of the burn dressing.

[0075] Specifically, adjusting the rotation speed of the stirring motor of the stirrer includes:

[0076] Comparing the variance of the concentration of the mixed solution with the preset second variance;

[0077] If the variance of the concentration of the mixed solution is greater than a preset second variance, increase the rotational speed of the stirring motor of the stirrer.

[0078] Specifically, the increase amplitude of the rotational speed of the stirring motor of the stirrer is determined by the difference between the variance of the concentration of the mixed solution and the preset second variance.

[0079] Specifically, when the difference between the variance of the concentration of the mixed solution and the preset second variance is within 0.5 (mol / L) 2 the rotational speed of the stirring motor of the stirrer is increased to 1.1 times the original; when the difference between the variance of the concentration of the mixed solution and the preset second variance exceeds 0.5 (mol / L) 2 on the basis of increasing to 1.1 times the original, for every 0.2 (mol / L) 2 exceeded, the rotational speed of the stirring motor of the stirrer is increased by 20 r / min. For example, when the difference between the variance of the concentration of the mixed solution and the preset second variance is 0.9 (mol / L) 2 and the current rotational speed of the stirring motor of the stirrer is 300 r / min, the increased rotational speed of the stirring motor of the stirrer is 300×1.1 + 20×2 = 370 r / min.

[0080] In implementation, in the method of the present invention, by setting a preset first variance and a preset second variance, the rotational speed of the stirring motor of the stirrer is adjusted. Since during the dissolution process of the active ingredient, there is a residue accumulation of the active ingredient on the inner wall of the mixing container, resulting in poor liquid flow during mixing, thus causing uneven mixing. By increasing the rotational speed of the stirring motor of the stirrer, a greater driving force can be provided by the stirrer to push the liquid to flow more quickly, which helps to overcome the flow resistance caused by the accumulation of residual substances, enables the liquid to circulate more fully in the container, reduces the uneven mixing area caused by poor flow, and further improves the preparation stability of the burn dressing.

[0081] Specifically, adjusting the tool feed rate of the cutting machine includes:

[0082] Obtain the roughness at the cut of the same side of several burn dressings, and calculate the average roughness at the cut of the burn dressing;

[0083] Compare the average roughness at the cut of the burn dressing with a preset first roughness and a preset second roughness respectively;

[0084] If the average roughness at the cut of the burn dressing is greater than the preset first roughness, it is determined that the forming effectiveness of the burn dressing does not meet the requirements;

[0085] If the average roughness at the cut of the burn dressing is greater than the preset first roughness and less than or equal to the preset second roughness, reduce the tool feed rate of the cutting machine;

[0086] If the average roughness of the incision of the burn dressing is greater than a preset second roughness, it is preliminarily determined that the drying effectiveness of the burn dressing does not meet the requirements, and it is determined whether the drying effectiveness of the burn dressing meets the requirements according to the drying rate of the burn dressing.

[0087] It can be understood that the three intervals divided by the preset first roughness and the preset second roughness respectively correspond to three situations:

[0088] The first interval is that the average roughness of the incision of the burn dressing is less than or equal to the preset first roughness, and the corresponding situation is: it is determined that the forming effectiveness of the burn dressing meets the requirements;

[0089] The second interval is that the average roughness of the incision of the burn dressing is greater than the preset first roughness and less than or equal to the preset second roughness, and the corresponding situation is: due to the wear of the cutting tool after long-term use, the cutting edge is no longer sharp, resulting in problems such as unsmooth cutting and rough incision;

[0090] The third interval is that the average roughness of the incision of the burn dressing is greater than the preset second roughness, and the corresponding situation is: due to the aging of the heating element in the drying equipment, the temperature in the drying equipment is uneven, resulting in uneven drying temperature.

[0091] In practice, the generally selected range of the preset first roughness is [3.5 μm, 4.5 μm], and the generally selected range of the preset second roughness is [4.6 μm, 5.6 μm].

[0092] Preferably, the preferred embodiment of the preset first roughness is 4 μm, and the preferred embodiment of the preset second roughness is 5 μm.

[0093] Specifically, the average roughness of the incision of the burn dressing is the ratio of the sum of the roughnesses of the incisions on the same side of several burn dressings to the number of burn dressings.

[0094] In implementation, the method of the present invention determines the forming effectiveness of the burn dressing by setting the preset first roughness and the preset second roughness, reduces the influence of the decrease in the preparation stability of the burn dressing caused by inaccurate determination of the forming effectiveness of the burn dressing, and further improves the preparation stability of the burn dressing.

[0095] Specifically, the reduction amplitude of the tool feed of the cutting machine is determined by the difference between the average roughness of the incision of the burn dressing and the preset first roughness.

[0096] Specifically, when the difference between the average roughness of the incision of the burn dressing and the preset first roughness is within 2 μm, the tool feed rate of the cutting machine is reduced to 0.9 times the original; when the difference between the average roughness of the incision of the burn dressing and the preset first roughness exceeds 2 μm, on the basis of being reduced to 0.9 times the original, for every 0.5 μm exceeded, the tool feed rate of the cutting machine is reduced by 0.1 mm / r. For example, if the difference between the average roughness of the incision of the burn dressing and the preset first roughness is 3 μm and the current tool feed rate of the cutting machine is 1 mm / r, the reduced tool feed rate of the cutting machine is 1×0.9 - 0.1×2 = 0.7 mm / r.

[0097] Specifically, mm / r is the unit of the tool feed rate of the cutting machine, and its meaning is millimeters per revolution.

[0098] In implementation, the method of the present invention adjusts the tool feed rate of the cutting machine by setting a preset first roughness and a preset second roughness. Since the tool used for cutting will be worn after long-term use and the cutting edge is no longer sharp, resulting in problems such as unsmooth cutting and rough incisions, by reducing the tool feed rate of the cutting machine, the tool can have a more sufficient contact time with the material during cutting, the depth and strength of each cut are relatively small, and the cutting action can be completed more finely, thereby improving the cutting effect, making the incision smoother, and further improving the preparation stability of the burn dressing.

[0099] Specifically, adjusting the air flow circulation speed in the hot air circulation oven includes:

[0100] Obtaining the mass of the burn dressing per unit time and calculating the drying rate of the burn dressing;

[0101] Comparing the drying rate of the burn dressing with the preset drying rate;

[0102] If the drying rate of the burn dressing is less than the preset drying rate, it is determined that the drying effectiveness of the burn dressing does not meet the requirements, and the air flow circulation speed in the hot air circulation oven is increased.

[0103] It can be understood that the two intervals divided by the preset drying rate respectively correspond to two situations:

[0104] The first interval is that the drying rate of the burn dressing is less than the preset drying rate, and the corresponding situation is: due to the aging of the heating element in the drying equipment, the temperature in the drying equipment is uneven, resulting in uneven drying temperature;

[0105] The second interval is that the drying rate of the burn dressing is greater than or equal to the preset drying rate, and the corresponding situation is: it is determined that the drying effectiveness of the burn dressing meets the requirements.

[0106] In practice, the generally selected range of the preset drying rate is [0.1 g / h, 0.3 g / h].

[0107] Preferably, a preferred embodiment of the preset drying rate is 0.2 g / h.

[0108] Specifically, the drying rate of the burn dressing is the absolute value of the difference between the mass of the burn dressing at the end moment per unit time and the mass of the burn dressing at the initial moment per unit time, divided by the duration of the unit time.

[0109] In implementation, the method of the present invention determines the drying effectiveness of the burn dressing by setting the preset drying rate, reducing the impact on the preparation stability of the burn dressing caused by inaccurate determination of the drying effectiveness of the burn dressing, and further improving the preparation stability of the burn dressing.

[0110] Specifically, the increase amplitude of the air flow circulation speed in the hot air circulation oven is determined by the difference between the preset drying rate and the drying rate of the burn dressing.

[0111] Specifically, when the difference between the preset drying rate and the drying rate of the burn dressing is within 0.1 g / h, the air flow circulation speed in the hot air circulation oven increases to 1.2 times the original; when the difference between the preset drying rate and the drying rate of the burn dressing exceeds 0.1 g / h, on the basis of increasing to 1.2 times the original, for every 0.1 g / h exceeded, the air flow circulation speed in the hot air circulation oven increases by 0.5 m / s. For example, when the difference between the preset drying rate and the drying rate of the burn dressing is 0.3 g / h and the current air flow circulation speed in the hot air circulation oven is 2 m / s, the increased air flow circulation speed in the hot air circulation oven is 2×1.2 + 0.5×2 = 3.4 m / s.

[0112] In implementation, the method of the present invention adjusts the air flow circulation speed in the hot air circulation oven by setting the preset drying rate. Due to the aging of the heating elements in the drying equipment, the temperature in the drying equipment is uneven, resulting in uneven drying temperature. By increasing the air flow circulation speed in the hot air circulation oven, the low-temperature area can absorb heat faster, reducing the temperature gap with the high-temperature area, thereby improving the uniformity of the temperature distribution and further enhancing the preparation stability of the burn dressing.

[0113] A burn dressing for treating skin wounds, comprising: silica gel, nylon textile fabric, type I collagen, vitamin C, and glycerol.

[0114] So far, the technical solution of the present invention has been described in conjunction with the preferred embodiments shown in the accompanying drawings. However, it is easily understood by those skilled in the art that the protection scope of the present invention is obviously not limited to these specific embodiments. Without departing from the principle of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will fall within the protection scope of the present invention.

Claims

1. A method for preparing a burn patch for treating skin wounds, characterized in that: include: Extracting collagen from fish by a bio-small molecule recovery method, dissolving effective ingredients and the collagen into a solvent using a stirrer to output a mixed solution, bonding silica gel and nylon textile fabric to output an adhesive film patch, and coating the mixed solution on one side of the nylon textile fabric of the adhesive film patch; The adhesive film patch coated with the mixed solution is dried using a hot air circulation oven, the dried adhesive film patch is cut using a cutting machine, and holes are punched on the silicone side of the cut adhesive film patch to output the burn patch; Obtaining the concentration of the mixed solution at several sampling points; The stability of the preparation of the burn patch was determined based on the variance of the concentration of the mixed solution; If the variance of the concentration of the mixed solution is greater than the preset first variance, it is determined that the preparation stability does not meet the requirements; if the variance of the concentration of the mixed solution is greater than the preset second variance, the stirring motor speed of the stirrer is increased; if the variance of the concentration of the mixed solution is greater than the preset first variance and less than or equal to the preset second variance, it is preliminarily determined that the molding effectiveness of the burn patch does not meet the requirements, and the molding effectiveness of the burn patch is preliminarily determined based on the average roughness at the incision of the burn patch; If the average roughness at the incision of the burn patch is greater than the preset first roughness, it is determined that the molding effectiveness does not meet the requirements; if the average roughness at the incision of the burn patch is greater than the preset first roughness and less than or equal to the preset second roughness, the tool feed rate of the cutting machine is reduced; if the average roughness at the incision of the burn patch is greater than the preset second roughness, it is preliminarily determined that the drying effectiveness of the burn patch does not meet the requirements, and the drying effectiveness of the burn patch is preliminarily determined based on the drying rate of the burn patch; if the drying rate of the burn patch is less than the preset drying rate, the airflow circulation speed in the hot air circulation oven is increased; The increase range of the stirring motor speed of the stirrer is determined by the difference between the variance of the concentration of the mixed solution and a preset second variance; The difference between the variance of the concentration of the mixed solution and the preset second variance is 0.5 (mol / L) 2 When the concentration variance of the mixed solution exceeds the preset second variance by more than 0.5 (mol / L), the stirring motor speed of the stirrer increases to 1.1 times of the original speed. 2 When the concentration increases to 1.1 times of the original value, the concentration increases by 0.2 (mol / L) 2 , the stirring motor speed of the stirrer increases by 20r / min; The reduction range of the feed rate of the cutter of the cutting machine is determined by the difference between the average roughness of the cutout of the burn patch and the preset first roughness; When the difference between the average roughness of the burn patch incision and the preset first roughness is within 2μm, the tool feed rate of the cutting machine is reduced to 0.9 times of the original value; when the difference between the average roughness of the burn patch incision and the preset first roughness exceeds 2μm, on the basis of being reduced to 0.9 times of the original value, the tool feed rate of the cutting machine is reduced by 0.1mm / r for every 0.5μm exceeding the original value; The increase range of the air circulation speed in the hot air circulation oven is determined by the difference between the preset drying rate and the drying rate of the burn patch; When the difference between the preset drying rate and the drying rate of the burn patch is within 0.1g / h, the air flow circulation speed in the hot air circulation oven is increased to 1.2 times the original speed; when the difference between the preset drying rate and the drying rate of the burn patch exceeds 0.1g / h, on the basis of being increased to 1.2 times the original speed, the air flow circulation speed in the hot air circulation oven is increased by 0.5m / s for every 0.1g / h exceeding the original speed.

2. A burn patch made by the method for preparing a burn patch for treating skin wounds according to claim 1, characterized in that: include: Silicone, nylon textile fabric, type I collagen, vitamin C, glycerin.

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