Traditional Chinese medicine composition for treating premature ovarian failure infertility and preparation and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating functional premature senility infertility and a preparation and application thereof, and relates to the field of traditional Chinese medicines. The traditional Chinese medicine composition for treating the ovarian function premature senility infertility comprises the following raw material medicines by weight: 14-18g of pulp of dogwood fruit, 14-18g of cistanche, 14-18g of morinda officinalis, 14-18g of cynomorium songaricum, 14-18g of herba epimedii, 8-12g of raspberry, 8-12g of semen cuscutae, 8-12g of fructus lycii, 8-12g of glossy privet fruit, 8-12g of mulberry, 14-18g of angelica sinensis and 14-18g of astragalus membranaceus. Fructus corni, cistanche, radix morindae officinalis, cynomorium songaricum, herba epimedii and raspberry are used as monarch drugs and can warm and tonify kidney yang and strengthen and nourish essence; according to the formula, semen cuscutae, fructus lycii, glossy privet fruit and glossy privet fruit are taken as ministerial drugs to nourish liver and kidney, nourish yin and strengthen essence, prevent essence injury caused by excessive warm tonification of monarch drugs, balance yin and yang and complement the curative effect; angelica sinensis is used for replenishing blood, astragalus membranaceus is used for tonifying qi, and the angelica sinensis and the astragalus membranaceus are used as adjuvant drugs and cooperate with monarch and ministerial drugs to replenish and strengthen essence; all the medicines supplement one another, promote one another and have a synergistic effect, and the curative effect on premature ovarian failure infertility is good.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating premature ovarian failure and infertility, and a preparation and application thereof. Background Art

[0002] Premature ovarian failure refers to the loss of normal ovarian function in women before the age of 40. It is the terminal stage of premature ovarian failure. The causes of premature ovarian failure mainly include the following aspects: (1) Genetic factors: Abnormal chromosome karyotype or gene defects can easily lead to premature ovarian failure. (2) Disease factors: Some diseases can cause ovarian failure, such as autoimmune diseases and infectious diseases, which may damage ovarian tissue and cause premature ovarian failure. (3) Adverse environmental factors: If women are in a cold, humid, high-radiation, or toxic environment for a long time, it is easy to cause ovarian failure. (4) Unhealthy lifestyle factors: Staying up late for a long time, smoking and drinking a lot can cause hypothalamic pituitary axis dysfunction, resulting in ovarian failure and premature ovarian failure. (5) Immune factors: Ovarian damage caused by autoimmune dysfunction is often manifested as premature ovarian failure. (6) Excessive weight loss: Fat is an important raw material for synthesizing estrogen. If a woman is too thin, estrogen production will be insufficient, causing premature ovarian failure.

[0003] The incidence of premature ovarian failure varies between different countries and regions, ranging from 4% to 13%. Clinical symptoms include abnormal menstruation, hot flashes, night sweats, memory loss, vaginal dryness, insomnia, emotional instability, and irritability.

[0004] Therefore, it is of great significance to develop a traditional Chinese medicine formula for treating premature ovarian failure and infertility. Summary of the invention

[0005] In view of this, the present invention proposes a Chinese medicine composition for treating premature ovarian failure and infertility, as well as a preparation and application thereof.

[0006] The technical solution of the present invention is achieved in this way:

[0007] A traditional Chinese medicine composition for treating infertility due to premature ovarian failure comprises the following raw materials in weight proportion: 14-18g of cornus fruit, 14-18g of cistanche deserticola, 14-18g of morinda officinalis, 14-18g of cynomorium songaricum, 14-18g of epimedium, 8-12g of raspberry, 8-12g of dodder seed, 8-12g of wolfberry fruit, 8-12g of glossy privet fruit, 8-12g of mulberry fruit, 14-18g of angelica sinensis and 14-18g of astragalus.

[0008] Preferably, the Chinese medicine composition for treating premature ovarian failure and infertility comprises the following raw materials in weight ratio: 14-16g of Cornus officinalis, 14-16g of Cistanche deserticola, 14-16g of Morinda officinalis, 14-16g of Cynomorium songaricum, 14-16g of Epimedium, 9-11g of Rubus idaeus, 9-11g of Cuscuta australis, 9-11g of Lycium barbarum, 9-11g of Ligustrum lucidum, 9-11g of Morus alba, 14-16g of Angelica sinensis, and 14-16g of Astragalus.

[0009] Preferably, the traditional Chinese medicine composition for treating premature ovarian failure and infertility comprises the following raw materials in the following weight ratio: 15g of Cornus officinalis, 15g of Cistanche deserticola, 15g of Morinda officinalis, 15g of Cynomorium songaricum, 15g of Epimedium, 10g of Rubus idaeus, 10g of Cuscuta australis, 10g of Lycium barbarum, 10g of Ligustrum lucidum, 10g of Morus alba, 15g of Angelica sinensis, and 15g of Astragalus.

[0010] A traditional Chinese medicine preparation for treating premature ovarian failure and infertility, comprising any one of the traditional Chinese medicine compositions of the present invention.

[0011] Preferably, the Chinese medicine composition preparation is one of decoction, granules and pills.

[0012] Use of any one of the Chinese medicine compositions of the present invention in preparing medicines for treating premature ovarian failure and infertility.

[0013] Premature ovarian failure belongs to the category of "amenorrhea" and "infertility" in traditional Chinese medicine. Traditional Chinese medicine believes that it is mainly caused by congenital deficiency or excessive sexual intercourse, improper diet, excessive fatigue, emotional disorder, phlegm and dampness, and insufficient qi and blood.

[0014] Fructus Corni is sour and astringent, warm in nature, and enters the liver and kidney meridians. It has the effects of tonifying the liver and kidney, astringing and consolidating, and is suitable for dizziness and tinnitus, impotence and spermatorrhea, soreness of the waist and knees, internal heat and thirst caused by liver and kidney deficiency; Cistanche deserticola is sweet and salty, warm in nature, and enters the kidney and large intestine meridians. It has the effects of tonifying kidney yang, benefiting essence and blood, and moistening the intestines and relieving constipation. It is used to treat kidney yang deficiency, essence and blood deficiency, impotence and premature ejaculation, dry intestine and constipation and other diseases; Morinda officinalis is pungent, sweet, slightly warm, and enters the kidney meridian. It has the effects of tonifying the kidney and assisting yang, dispelling wind and removing dampness, and is clinically used for impotence, frequent urination, infertility, irregular menstruation, cold pain in the lower abdomen and other symptoms; Herba Cistanches is sweet and warm in nature, and enters the liver, kidney and large intestine meridians. It has the effects of tonifying the kidney and assisting yang, It has the effect of moistening the intestines and promoting bowel movements, and is used to treat chills, impotence, premature ejaculation, lower limb weakness, limb fatigue and other symptoms caused by kidney yang deficiency and kidney essence deficiency; Epimedium is pungent and sweet, and warm in nature. It enters the liver and kidney meridians. It has the effects of tonifying the kidney and strengthening yang, dispelling wind and dampness, relieving cough and relieving asthma. It can be used to treat impotence, weakness of the waist and knees, weakness of the tendons and bones, enuresis, frequent urination, cold and dull pain in the abdomen, and infertility due to uterine cold; Raspberry is warm in nature, sweet and sour in taste, and enters the liver, kidney and bladder meridians. It benefits the kidney, consolidates the essence, reduces urine, nourishes the liver and improves eyesight. It is used to treat spermatorrhea, spermatorrhea, frequent urination, enuresis, premature ejaculation, impotence, dark eyes and blurred vision caused by liver and kidney deficiency.

[0015] This prescription uses Cornus officinalis, Cistanche deserticola, Morinda officinalis, Cynomorium songaricum, Epimedium and Rubus idaeus as the main ingredients to warm and nourish the kidney yang, strengthen the essence and improve the blood circulation.

[0016] Cuscuta chinensis is pungent and sweet in taste, neutral in nature, and enters the liver, kidney, and spleen meridians. It has the effects of nourishing the liver and kidney, consolidating essence and reducing urine, calming the fetus, improving eyesight, and stopping diarrhea. It is often used for soreness of the waist and knees due to liver and kidney deficiency, impotence and spermatorrhea, enuresis and frequent urination, kidney deficiency and fetal leakage, fetal movement disorder, blurred vision and tinnitus, and diarrhea due to spleen and kidney deficiency. Lycium barbarum is sweet and neutral in nature, and enters the liver and kidney meridians. It nourishes the kidney, moistens the lungs, nourishes the liver, and improves eyesight. It is suitable for treating soreness of the waist and knees, dizziness, blurred vision and excessive tears due to liver and kidney yin deficiency. It can be used to treat symptoms such as cough due to deficiency, thirst, and spermatorrhea; Fructus Ligustri Lucidi is bitter, sweet, and cool, and it enters the kidney and liver meridians. It has the effects of nourishing the liver and kidney, blackening the beard and improving the eyesight. It is suitable for symptoms such as dizziness and tinnitus, soreness of the waist and knees, premature graying of hair, blurred vision, and hyperlipidemia; Mulberry seed is sour, sweet, and cold, and it enters the kidney and liver meridians. It has the effects of nourishing blood and yin, nourishing the liver and kidney, and promoting fluid production and quenching thirst. It can treat symptoms such as dizziness, insomnia, premature graying of hair, thirst, constipation, deafness and tinnitus caused by liver and kidney yin deficiency.

[0017] In this prescription, Cuscuta australis, Lycium barbarum, Ligustrum lucidum, and Ligustrum lucidum are combined as assistant herbs to nourish the liver and kidneys, nourish yin and benefit essence, and prevent the main herbs from warming and nourishing too much and damaging essence, so as to balance yin and yang and achieve remarkable therapeutic effect.

[0018] Angelica sinensis is slightly sweet, pungent and warm in nature, and enters the heart, liver and spleen meridians. It has the effects of nourishing Qi and blood, promoting blood circulation and removing blood stasis, and moistening the intestines and promoting bowel movements. It is an excellent blood tonic and is used to treat symptoms such as pale complexion, palpitations and insomnia, dizziness, dry eyes, etc. caused by blood deficiency.

[0019] Astragalus is sweet and slightly warm in nature, and enters the spleen and lung meridians. It has the effects of strengthening the spleen and replenishing the middle, raising yang and lifting the sunken, benefiting the body's defense system and consolidating the exterior, promoting diuresis, and expelling toxins and promoting tissue regeneration. It is suitable for treating symptoms such as physical weakness, prolapse of the anus, spontaneous sweating, night sweats, physical weakness, uterine prolapse, and non-healing wounds.

[0020] In this prescription, Angelica sinensis is an excellent blood tonic, and Astragalus membranaceus is a good qi tonic. Together they serve as adjuvants, working together with the main and auxiliary herbs to replenish and strengthen sperm. The herbs complement each other, promote each other, and work synergistically, and have a good effect in treating infertility caused by premature ovarian failure.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] The prescription of the present invention uses cornus fruit, cistanche deserticola, morinda officinalis, cynomorium songaricum, epimedium and raspberry to warm and nourish kidney yang, strengthen sperm and benefit sperm, and are collectively the main medicines; the prescription uses dodder seed, wolfberry fruit, glossy privet fruit and glossy privet fruit as the assistant medicines to nourish the liver and kidney, nourish yin and benefit sperm, and prevent the main medicine from warming and nourishing too much to damage sperm, so as to balance yin and yang and achieve effective treatment; the prescription uses angelica sinensis to nourish blood, and astragalus membranaceus to nourish qi, and cooperates with the main and assistant medicines to nourish sperm and strengthen sperm, and are collectively the adjuvants; the medicines complement each other, promote each other, and synergize to enhance the effect, and have a good therapeutic effect on the treatment of premature ovarian failure and infertility, with a total effective rate of 95.31%, of which the cure rate is 68.23%. DETAILED DESCRIPTION

[0023] In order to better understand the technical content of the present invention, specific embodiments are provided below to further illustrate the present invention.

[0024] Unless otherwise specified, the experimental methods used in the embodiments of the present invention are all conventional methods.

[0025] Unless otherwise specified, the materials, reagents, etc. used in the embodiments of the present invention can be obtained from commercial sources.

[0026] Example 1

[0027] Chinese medicine formula for the treatment of premature ovarian failure and infertility: 15g of cornus fruit, 15g of Cistanche deserticola, 15g of Morinda officinalis, 15g of Cynomorium songaricum, 15g of Epimedium, 10g of Rubus idaeus, 10g of Cuscuta australis, 10g of Lycium barbarum, 10g of Ligustrum lucidum, 10g of Morus alba, 15g of Angelica sinensis, and 15g of Astragalus. Preparation method:

[0028] (1) According to the above formula, take cornus fruit, Cistanche deserticola, Morinda officinalis, Cynomorium songaricum, Epimedium, Rubus idaeus, Cuscuta australis, Lycium barbarum, Ligustrum lucidum, Morus alba, Angelica sinensis, and Astragalus membranaceus, decoct in water twice, filter, collect decoction I, reserve the residue for later use, and take decoction I orally;

[0029] Decoction method: Add water to cover the medicinal materials by 1 to 2 cm, soak for 30 minutes, and boil for 30 minutes each time.

[0030] (2) Add water to the residue from step (1) and boil it (add water to cover the residue by 1 to 2 cm), keep boiling for 10 minutes to obtain decoction II, which is used for foot bathing for 30 minutes.

[0031] Example 2

[0032] Chinese medicine formula for treating premature ovarian failure and infertility: 14g of cornus fruit, 18g of Cistanche deserticola, 14g of Morinda officinalis, 18g of Cynomorium songaricum, 14g of Epimedium, 12g of Rubus idaeus, 8g of Cuscuta australis, 12g of Lycium barbarum, 8g of Ligustrum lucidum, 12g of Morus alba, 18g of Angelica sinensis, and 14g of Astragalus. The preparation method is the same as that in Example 1.

[0033] Example 3

[0034] Chinese medicine formula for treating premature ovarian failure and infertility: 18g of cornus fruit, 14g of Cistanche deserticola, 18g of Morinda officinalis, 14g of Cynomorium songaricum, 18g of Epimedium, 8g of Rubus idaeus, 12g of Cuscuta australis, 8g of Lycium barbarum, 12g of Ligustrum lucidum, 8g of Morus alba, 14g of Angelica sinensis, and 18g of Astragalus. The preparation method is the same as that in Example 1.

[0035] Example 4

[0036] Chinese medicine formula for treating premature ovarian failure and infertility: 14g of cornus fruit, 16g of Cistanche deserticola, 14g of Morinda officinalis, 16g of Cynomorium songaricum, 14g of Epimedium, 9g of Rubus idaeus, 11g of Cuscuta australis, 9g of Lycium barbarum, 11g of Ligustrum lucidum, 9g of Morus alba, 16g of Angelica sinensis, and 14g of Astragalus. Decoction is made. The preparation method is the same as that of Example 1.

[0037] Clinical observation study example

[0038] 1. Materials and methods

[0039] 1.1 General data This group of cases is an outpatient case collected over the years, with an age range of 23 to 39 years old. There were 48 cases with genetic factors, 73 cases with disease factors, 112 cases with adverse environmental factors, 246 cases with adverse lifestyle factors, 102 cases with immune factors, 56 cases with excessive weight loss, and 68 cases with other factors.

[0040] 1.2 Diagnostic Basis

[0041] 1) The age of menarche is often abnormal, and patients may experience menstrual disorders and then amenorrhea; or patients may have regular menstruation at first but then experience menstrual disorders; there are also patients who experience sudden amenorrhea (those who have been pregnant or given birth); or if a woman has long-term amenorrhea before the age of 40, and the duration is more than 4 months.

[0042] 2) Clinical symptoms: hot flashes, night sweats, sleep disorders, depression, facial flushing, decreased libido, chloasma, acne, rough and dull facial skin, etc.; some women will experience decreased libido and memory loss; some women will also develop wrinkles and spots prematurely, such as dryness and yellowing, and some patients will have red facial features

[0043] 3) Ultrasound examination: indicates that the ovaries are atrophied and reduced in size.

[0044] 4) Endocrine function examination: For amenorrhea patients with negative progesterone test, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL) should be measured. Those with normal PRL and FSH>40u / L should be suspected of premature ovarian failure.

[0045] 2. Treatment prescription and treatment method

[0046] 2.1. Prescription: 15g of Cornus officinalis, 15g of Cistanche deserticola, 15g of Morinda officinalis, 15g of Cynomorium songaricum, 15g of Epimedium, 10g of Rubus idaeus, 10g of Cuscuta australis, 10g of Lycium barbarum, 10g of Ligustrum lucidum, 10g of Morus alba, 15g of Angelica sinensis, and 15g of Astragalus, which is the Chinese medicine formula of Example 1.

[0047] 2.2 Method: decoct twice, take in the morning and evening, decoct the remaining medicine residue in water for 10 minutes, and then bathe your feet for 30 minutes one hour before going to bed. 15 days is one course of treatment, and two courses of treatment are required to observe the efficacy.

[0048] 3. Efficacy determination

[0049] 3.1. Cure: B-ultrasound examination shows that the ovaries are of normal shape and size, endocrine function examination is normal, symptoms are eliminated, menstruation is normal, and pregnancy occurs within 2 to 3 months.

[0050] 3.2. Improvement: B-ultrasound reexamination showed that the ovaries were small, endocrine function reexamination showed improvement, symptoms were alleviated, menstruation was basically normal, and no pregnancy within 6 months.

[0051] 3.3. Ineffective: B-ultrasound examination showed ovarian atrophy, endocrine function examination was abnormal, amenorrhea and symptoms did not change.

[0052] 4. Efficacy results

[0053] 481 cases were cured, accounting for 68.23%; 191 cases improved, accounting for 27.09%; 33 cases were ineffective, accounting for 4.68%, and the overall effective rate was 95.32%.

[0054] Table 1 Therapeutic results of premature ovarian failure and infertility

[0055] Total number of cases cure Improvement invalid Total effective Number of cases 705 cases 481 cases 191 cases 33 cases 672 cases Proportion -- 68.23％ 27.09％ 4.68％ 95.32％

[0056] 5. Analysis

[0057] Premature ovarian failure belongs to the category of "amenorrhea" and "infertility" in traditional Chinese medicine. Traditional Chinese medicine believes that it is mainly caused by congenital deficiency or excessive sexual intercourse, improper diet, excessive fatigue, emotional disorder, phlegm and dampness, and insufficient qi and blood.

[0058] Cornus officinalis tastes sour and astringent, is warm in nature, and enters the liver and kidney meridians. It has the effects of nourishing the liver and kidney, astringing and consolidating. It is suitable for dizziness and tinnitus, impotence and spermatorrhea, sore waist and knees, internal heat and thirst caused by liver and kidney deficiency; Cistanche deserticola tastes sweet and salty, is warm in nature, and enters the kidney and large intestine meridians. It has the effects of nourishing kidney yang, benefiting essence and blood, and moistening the intestines and relieving constipation. It is used to treat kidney yang deficiency, essence and blood deficiency, impotence and premature ejaculation, dry intestines and constipation. Morinda officinalis is pungent, sweet, slightly warm, and enters the kidney meridian. It has the effects of nourishing the kidney and yang, and dispelling wind and dampness. It is clinically used for impotence, frequent urination, infertility, irregular menstruation, cold pain in the lower abdomen, etc.; Lock Yang tastes sweet and warm, and enters the liver, kidney, and large intestine meridians. It has the effects of nourishing the kidney and yang, and moistening the intestines and relieving constipation. It is used to treat chills, impotence, premature ejaculation, lower limb weakness, and limb fatigue caused by kidney yang deficiency and insufficient kidney essence; Epimedium is pungent and sweet, warm in nature, and enters the liver and kidney meridians. It has the effects of tonifying the kidney and strengthening yang, dispelling wind and dampness, and relieving cough and asthma. It can be used to treat impotence, weakness in the waist and knees, weakness of tendons and bones, enuresis and frequent urination, cold and dull pain in the abdomen, and infertility caused by uterine coldness; Raspberry is warm in nature, sweet and sour in taste, and enters the liver, kidney, and bladder meridians. It has the effects of benefiting the kidney, consolidating essence, reducing urine, nourishing the liver, and improving eyesight. It is used to treat spermatorrhea, spermatorrhea, frequent urination, enuresis, premature ejaculation, impotence, dark eyes, and blurred vision caused by liver and kidney deficiency.

[0059] The cornus fruit, Cistanche deserticola, Morinda officinalis, Cynomorium songaricum, Epimedium and Rubus idaeus in this prescription can all warm and nourish the kidney yang, strengthen the essence and benefit the sperm, and are the main medicines.

[0060] Cuscuta chinensis is pungent and sweet in taste, and is neutral in nature. It enters the liver, kidney, and spleen meridians. It has the effects of nourishing the liver and kidney, consolidating essence and reducing urine, calming the fetus, improving eyesight, and stopping diarrhea. It is often used for soreness of the waist and knees due to liver and kidney deficiency, impotence and spermatorrhea, enuresis and frequent urination, kidney deficiency and fetal leakage, fetal movement disorder, blurred vision and tinnitus, spleen and kidney deficiency and diarrhea; Lycium barbarum is sweet and neutral in nature, and enters the liver and kidney meridians. Functions nourish the kidney, moisten the lungs, nourish the liver, and improve eyesight. It is suitable for treating soreness of the waist and knees, dizziness, vertigo, blurred vision and tears, asthenia cough, thirst, and spermatorrhea due to liver and kidney yin deficiency; Ligustrum lucidum is bitter, sweet, and cool, and enters the kidney and liver meridians. It has the effects of nourishing the liver and kidney, black beard and improving eyesight. It is suitable for dizziness and tinnitus, soreness of the waist and knees, premature graying of hair, dark eyes, and hyperlipidemia; Mulberry is sour, sweet, and cold, and enters the kidney and liver meridians. It has the effects of nourishing blood and yin, nourishing the liver and kidney, and promoting body fluid and quenching thirst. It can treat dizziness, insomnia, premature graying of hair, thirst, constipation, deafness and tinnitus caused by liver and kidney yin deficiency.

[0061] In this prescription, Cuscuta australis, Lycium barbarum, Ligustrum lucidum, and Ligustrum lucidum are used as assistant herbs to nourish the liver and kidneys, nourish yin and benefit essence, and prevent the main herbs from excessively warming and nourishing the essence, so as to balance yin and yang and achieve remarkable therapeutic effects.

[0062] Angelica sinensis is slightly sweet, pungent and warm in nature and flavor, and enters the heart, liver and spleen meridians. It has the effects of nourishing qi and blood, promoting blood circulation and removing blood stasis, and moistening the intestines and relieving constipation. It is an excellent blood tonic and is used to treat pale complexion, palpitations, insomnia, dizziness, dry eyes and other symptoms caused by blood deficiency.

[0063] Astragalus is sweet and slightly warm in nature. It enters the spleen and lung meridians. Astragalus has the effects of strengthening the spleen and replenishing the middle, raising yang and lifting the sunken, benefiting the body's defense and strengthening the exterior, promoting urination, and expelling toxins and promoting muscle growth. It is suitable for treating symptoms such as physical weakness, prolapse of the anus, spontaneous sweating, night sweats, physical weakness, uterine prolapse, and wounds that do not heal.

[0064] In this prescription, Angelica sinensis is used to replenish blood, and Astragalus membranaceus is used to replenish Qi. They serve as adjuvant drugs, working together with the main and auxiliary drugs to replenish and strengthen essence. The drugs complement each other, promote each other, and enhance their effects synergistically. It has a good effect on the treatment of infertility caused by premature ovarian failure, with a total effective rate of 95.32%, of which the cure rate is 68.23%.

[0065] Comparative test study

[0066] The preparations were carried out according to the following formulas and the preparation method was referred to Example 1.

[0067] Serial number Medicinal Materials Control group 1 (g) Comparative group 2 (g) Control group 3 (g) Control group 4 (g) 1 Cornus officinalis 30 0 10 15 2 Cistanche deserticola 0 30 10 15 3 Morinda officinalis 30 0 10 15 4 Cynomorium songaricum 0 30 10 15 5 Epimedium 25 0 10 15 6 raspberry 10 25 10 15 7 Cuscuta 10 10 20 15 8 Wolfberry 10 10 0 15 9 Ligustrum lucidum 10 10 20 15 10 Mulberry 10 10 0 15 11 Angelica 15 15 10 15 12 Astragalus 15 15 10 15

[0068] In the clinical study, the results showed that the efficacy of the control groups 1-4 in treating premature ovarian failure and infertility was significantly different from that of Example 1, and their efficacy levels were significantly lower than that of Example 1.

[0069] In summary, the drugs of the present invention complement each other, promote each other, and synergize to enhance the efficacy, and have a good effect in treating premature ovarian failure and infertility.

[0070] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating premature ovarian failure and infertility, characterized in that: Including the following raw materials in weight ratio: Cornus officinalis 14-18g, Cistanche deserticola 14-18g, Morinda officinalis 14-18g, Cynomorium songaricum 14-18g, Epimedium 14-18g, Rubus 8-12g, Cuscuta australis 8-12g, Lycium barbarum 8-12g, Ligustrum lucidum 8-12g, Morus alba 8-12g, Angelica sinensis 14-18g, Astragalus membranaceus 14-18g.

2. The Chinese medicine composition for treating premature ovarian failure and infertility according to claim 1, characterized in that: Including the following raw materials in weight ratio: Cornus officinalis 14-16g, Cistanche deserticola 14-16g, Morinda officinalis 14-16g, Cynomorium songaricum 14-16g, Epimedium 14-16g, Rubus 9-11g, Cuscuta australis 9-11g, Lycium barbarum 9-11g, Ligustrum lucidum 9-11g, Morus alba 9-11g, Angelica sinensis 14-16g, Astragalus membranaceus 14-16g.

3. The Chinese medicine composition for treating premature ovarian failure and infertility according to claim 1, characterized in that: Including the following raw materials in weight ratio: 15g of cornus fruit, 15g of Cistanche deserticola, 15g of Morinda officinalis, 15g of Cynomorium songaricum, 15g of Epimedium, 10g of Rubus idaeus, 10g of Cuscuta australis, 10g of Lycium barbarum, 10g of Ligustrum lucidum, 10g of Morus alba, 15g of Angelica sinensis, and 15g of Astragalus.

4. A Chinese medicine preparation for treating premature ovarian failure and infertility, characterized in that: A Chinese medicine composition comprising any one of claims 1 to 3.

5. The Chinese medicine preparation for treating premature ovarian failure and infertility according to claim 1, characterized in that: The Chinese medicine composition preparation is one of decoction, granules and pills.

6. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating infertility due to premature ovarian failure.