Moisturizing and soothing composition containing sodium hyaluronate and application of moisturizing and soothing composition in skin care of infants and children

Abstract

The invention belongs to the technical field of preparation of daily necessities, and particularly relates to a moisturizing and soothing composition containing sodium hyaluronate and application of the moisturizing and soothing composition in skin care of infants and children. The hyaluronic acid moisturizing mask is prepared from the following raw materials in parts by mass: 0.01 to 0.05 part of sodium hyaluronate, 5 to 25 parts of a moisturizing component, 0.01 to 0.7 part of a soothing component and 0.1 to 6 parts of a skin moistening component, the moisturizing component is prepared from at least one of glycerol, 1, 3-butanediol and 1, 3-propylene glycol; the soothing component is prepared from at least one of allantoin, bisabolol and a radix gentianae extract; the skin moistening component comprises shea butter and / or hydrogenated coconut oil. After the sodium hyaluronate is added, the composition can promote the metabolism of cuticle cells and assist in barrier repair; after the moisturizing component and the relieving component are compounded, the composition can directly supplement skin lipid, form a protective layer, inhibit release of inflammatory factors and relieve redness and stabbing caused by barrier damage, and is suitable for delicate skin of infants and children.

Description

Technical Field

[0001] This invention belongs to the field of daily necessities preparation technology, specifically relating to a moisturizing and soothing composition containing sodium hyaluronate and its application in infant skincare. Background Technology

[0002] Infants, especially young children, have a stratum corneum that is only one-third the thickness of an adult's. Their skin barrier is not yet fully developed, resulting in weak water retention and rapid moisture loss, making them highly susceptible to dryness, peeling, and redness. Therefore, alleviating dry skin in infants and young children is a hot research topic in this field.

[0003] Existing research has found that sodium hyaluronate is commonly used to relieve dry and uncomfortable skin. For example, Chinese patent CN114948834 A describes a soothing and moisturizing essence and its preparation method. This essence, prepared by mixing olive leaf extract, glyceryl glucoside, tetrahydromethylpyrimidine carboxylic acid, plant extracts, moisturizers, preservatives, antioxidants, and solvents, provides a soothing and moisturizing effect through olive leaf extract, which also inhibits melanocytes and has a whitening effect on the skin. Glyceryl glucoside provides moisturizing and antioxidant functions; tetrahydromethylpyrimidine carboxylic acid provides good moisturizing function and protects neutrophils to achieve an anti-inflammatory effect; and sodium hyaluronate provides a stronger moisturizing effect. Another example is Chinese patent CN 117731582. A method for preparing a bamboo-based soothing and moisturizing facial mask involves mixing bamboo leaf extract, bamboo shoot extract, bamboo charcoal powder, sodium hyaluronate, glycerin, wheat germ oil, lavender essential oil, licorice extract, green tea extract, soy isoflavones, aloe vera extract, jujube extract, and water. The resulting composition possesses antioxidant and anti-inflammatory effects, improves dullness and redness, and provides deep cleansing and exfoliation, leaving skin smoother and more delicate. However, research on the preparation of infant skincare products using sodium hyaluronate is limited. Providing a moisturizing and soothing composition containing sodium hyaluronate for use in infant skincare would significantly expand the market prospects for infant skincare products. Summary of the Invention

[0004] The purpose of this invention is to provide a moisturizing and soothing composition containing sodium hyaluronate and its application in infant skincare, which has significant moisturizing and soothing effects and is suitable for the delicate skin of infants.

[0005] This invention provides a moisturizing and soothing composition containing sodium hyaluronate, comprising the following raw materials in parts by weight: Sodium hyaluronate 0.01-0.05 parts, moisturizing ingredients 5-25 parts, soothing ingredients 0.01-0.7 parts, and skin-moisturizing ingredients 0.1-6 parts; The moisturizing ingredients include at least one of glycerin, 1,3-butanediol, and 1,3-propanediol; The soothing ingredients include at least one of allantoin, bisabolol and gentian root extract; The moisturizing ingredients include shea butter and / or hydrogenated coconut oil.

[0006] Preferably, when the moisturizing ingredient is composed of glycerin and 1,3-butanediol, the mass ratio of glycerin to 1,3-butanediol is 3-18:2-4. When allantoin and gentian root extract are used as the soothing ingredients, the mass ratio of allantoin to gentian root extract is 0.1:0.06. When bisabolol and gentian root extract are used to form a soothing ingredient, the mass ratio of bisabolol to gentian root extract is 0.1:0.06. When shea butter and hydrogenated coconut oil are used as moisturizing ingredients, the mass ratio of shea butter to hydrogenated coconut oil is 1-3:1-3.

[0007] Preferably, the ingredients, by weight, include the following raw materials: Sodium hyaluronate 0.05 parts, moisturizing ingredients 9 parts, soothing ingredients 0.7 parts, and skin-nourishing ingredients 3 parts; The moisturizing ingredient is composed of glycerin and 1,3-butanediol in a mass ratio of 5:4. The soothing ingredients consist of allantoin, bisabolol, and gentian root extract in a mass ratio of 0.5:0.1:0.1. The moisturizing ingredient is hydrogenated coconut oil.

[0008] Preferably, the method for preparing the gentian root extract includes: The plant sample, endoglucanase, and water were ultrasonically mixed to obtain a mixture. The mixture and brewer's yeast were subjected to aerobic fermentation, solid-liquid separation, and concentration and drying to obtain gentian root extract.

[0009] Preferably, during ultrasonic mixing, the mass ratio of the plant sample, endoglucanase, and water is 10-20:1-5:80-90; The ultrasonic mixing temperature is 43-48℃, the time is 3-5h, and the power is 350-500w.

[0010] Preferably, during aerobic fermentation, the mass ratio of the mixture to brewer's yeast is 100:6-10; The effective viable count of the brewer's yeast is ≥1.5×10⁻⁶. 7 cfu / g; The aerobic fermentation is carried out at a temperature of 35-39℃ for 36-48 hours.

[0011] This invention provides the application of the moisturizing and soothing composition described above in the preparation of infant skincare products.

[0012] Preferably, the product includes: body lotion or face cream.

[0013] This invention provides a face cream specifically for infants and children, comprising the moisturizing and soothing composition described in the above-mentioned technical solution.

[0014] Preferably, the ingredients, by weight, include the following raw materials: The above-described technical solution comprises 13.34 parts of moisturizing and soothing composition, 1.2 parts of thickener, 5 parts of emulsifier, 2.0 parts of skin conditioning agent, 0.1 parts of fragrance, and 78.36 parts of water.

[0015] Beneficial effects: This invention provides a moisturizing and soothing composition containing sodium hyaluronate, comprising, by weight, the following ingredients: 0.01-0.05 parts sodium hyaluronate, 5-25 parts moisturizing ingredients, 0.01-0.7 parts soothing ingredients, and 0.1-6 parts skin-moisturizing ingredients; wherein the moisturizing ingredients include at least one of glycerin, 1,3-butanediol, and 1,3-propanediol; wherein the soothing ingredients include at least one of allantoin, bisabolol, and gentian root extract; and wherein the skin-moisturizing ingredients include shea butter and / or hydrogenated coconut oil.

[0016] With the addition of sodium hyaluronate, this composition can promote the metabolism of stratum corneum cells and assist in barrier repair. When combined with moisturizing and soothing ingredients, this composition can directly replenish skin lipids and form a protective layer, inhibit the release of inflammatory factors, and relieve redness and stinging caused by barrier damage, making it suitable for the delicate skin of infants and children. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the accompanying drawings used in the embodiments will be briefly described below.

[0018] Figure 1 Examples of facial redness changes before and after use of the sample provided in this invention. Detailed Implementation

[0019] In this invention, unless otherwise specified, the raw materials, equipment and methods used are all conventional selections.

[0020] Information on some of the raw materials used in this invention: Sodium hyaluronate (HA) was purchased from Guangzhou Meichangwan Biomedical Technology Co., Ltd., under the trade name Sodium Hyaluronate (molecular weight: 800,000-1,800,000); allantoin was purchased from Beijing Sampo Biochemical Technology Co., Ltd., under the trade name Sampo® Allantoin; bisabolol was purchased from BASF (China) Co., Ltd., under the trade name Bisabolol rac.; Carbomer 940 was purchased from SUMITOMO SEIKA CHEMICALS CO., LTD., under the trade name AQUPEC HV-505E; shea butter was purchased from Clariant Chemicals (Shanghai) Co., Ltd., under the trade name Plantasens Shea Butter Ref; and hydrogenated coconut oil was purchased from Nanhai Oils & Fats Industry (Chiwan) Co., Ltd., under the trade name GUAMATE SRB.

[0021] To further illustrate the present invention, the solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0022] Examples and comparative examples were set up according to the various raw material usage amounts shown in Table 1.

[0023] Table 1. Amount of each raw material used in different treatments

[0024] In the examples and comparative examples described in Table 1, the preparation method of the raw material gentian root extract is as follows: Gentiana scabra (… Gentiana manshurica Kitag. was cleaned, dried, and pulverized to obtain a pulverized material for later use; the pulverized material, endoglucanase, and water were mixed at a mass ratio of 10:1:90 and ultrasonically mixed at 500w and 48℃ for 3 hours to obtain a mixture; the mixture was then mixed with brewer's yeast ( Saccharomyces cerevisiae The effective viable bacteria count is 1.5 × 10⁻⁶. 7 The gentian root extract was obtained by mixing (cfu / g) at a mass ratio of 100:10 and fermenting aerobically at 39°C for 48 hours. The fermentation product was then subjected to solid-liquid separation, concentration and drying (concentration was stopped when the mass of the substance no longer changed).

[0025] According to the amount of raw materials in Table 1, mix each raw material evenly to obtain moisturizing and soothing compositions.

[0026] Safety testing The moisturizing and soothing compositions prepared in Examples 1-12 and Comparative Examples 1-5 were used as test substances. Japanese plover rabbits were used as test subjects, with one rabbit assigned to each test composition and clearly marked. Twenty-four hours before the experiment, the fur on both sides of the spine on the back of the Japanese plover rabbits was shaved off, yielding rabbits with a surface area of ​​5 cm². 2 The hair-removed areas of the Japanese plover were examined, and any abnormalities (erythema, edema) were observed on the hair-removed areas of the Japanese plover's back. After confirming no abnormalities were observed, 0.5g of each test composition was applied directly to the left side of the hair-removed skin on the back of the Japanese plover (the right side of the skin was left untreated as a control), covered with clean gauze, and fixed with non-irritating adhesive tape. After 24 hours, the gauze was removed, and the residual test material was removed with warm water. The skin at the application site was observed for any abnormalities such as erythema or edema at 1 hour, 24 hours, and 48 hours after the removal of the test material. The results are shown in Table 2.

[0027] Table 2. Abnormalities in different treatments

[0028] The results showed that when the moisturizing and soothing compositions prepared in the examples or comparative examples were applied to the skin of Japanese rabbits, no abnormalities such as erythema or edema occurred, indicating that the above-mentioned moisturizing and soothing compositions have no acute skin irritation and are highly safe.

[0029] Comparative Example 6 The only difference from Example 12 is that the gentian root extract used in Comparative Example 6 was purchased conventionally.

[0030] Comparative Example 7 The only difference from Example 12 is that the preparation method of the gentian root extract used in Comparative Example 7 is as follows: Clean and dry the gentian leaves, then crush them to obtain a powder for later use; combine the powder with brewer's yeast ( Saccharomyces cerevisiae The effective viable bacteria count is 1.5 × 10⁻⁶. 7 Gentian root extract was obtained by mixing (cfu / g) and water at a mass ratio of 10:10:90 and fermenting aerobically at 39°C for 48 hours. The fermentation product was then subjected to solid-liquid separation, concentration and drying (concentration was stopped when the mass of the substance no longer changed).

[0031] Comparative Example 8 The only difference from Example 12 is that the preparation method of the gentian root extract used in Comparative Example 8 is as follows: Clean, dry, and pulverize the *Gentiana scabra* leaves to obtain a pulverized material. Mix the pulverized material, endoglucanase, and water at a mass ratio of 10:1:90, and sonicate at 500 W and 48°C for 3 hours to obtain a mixture. Then, mix the mixture with *Lactobacillus plantarum* (…). Lactobacillus plantarum The effective viable bacteria count is 1.5 × 10⁻⁶. 7The gentian root extract was obtained by mixing (cfu / g) at a mass ratio of 100:10 and anaerobic fermenting at 39℃ for 48 hours. The fermentation product was then subjected to solid-liquid separation, concentration and drying (concentration was stopped when the mass of the substance no longer changed).

[0032] Comparative Example 9 The only difference from Example 12 is that the preparation method of the gentian root extract used in Comparative Example 9 is as follows: Gentian root extract was cleaned, dried, and pulverized. The pulverized material was then mixed with water at a mass ratio of 1:10 and boiled at 60°C for 45 minutes. The mixture was then filtered to obtain the first filtrate and the first residue. The first residue was then mixed with water at a mass ratio of 1:10 and boiled at 60°C for 45 minutes. The mixture was then filtered to obtain the second filtrate. The first and second filtrates were combined and concentrated and dried until the weight of the substances no longer changed, thus obtaining the gentian root extract.

[0033] Moisturizing test 0.500 g of each of the moisturizing and soothing compositions prepared in Examples 1-12 and Comparative Examples 1-9 (each moisturizing and soothing composition was a treatment, and each treatment was repeated three times in parallel) was placed in a glass petri dish, and 0.200 g of distilled water was added evenly. The dishes were then placed in a desiccator at 25°C and in color-changing silica gel (relative humidity 0%). The mass of the petri dishes and samples was weighed at 12 h and 24 h, respectively (the initial moisturizing rate at 0 h was 100%). The moisturizing rate was calculated according to the following formula (moisturizing rate % = W / W1 × 100%, where W1 is the initial mass of the petri dish and sample, g; W is the mass of the petri dish and sample after a specific time, g). The results are shown in Table 3.

[0034] Table 3. Results of moisturizing rate under different treatments

[0035] Based on the results in Table 3, compared with the comparative example, the moisturizing and soothing composition prepared by mixing the raw materials in appropriate amounts in the examples has a good moisturizing effect.

[0036] Preparing baby face cream By weight, baby face cream is composed of the following ingredients: The composition comprises 13.34 parts moisturizing and soothing agent, 1.2 parts thickener, 5 parts emulsifier, 2 parts skin conditioning agent, 0.1 parts fragrance and 78.36 parts water; The thickener is a mixture of SEPIGEL 305 and Carbomer 940 in a mass ratio of 10:1. The emulsifier is a mixture of SP ARLACEL 170 and M-68 emulsifiers in a mass ratio of 2:1.

[0037] The moisturizing and soothing composition consists of HA, glycerin, 1,3-butanediol, allantoin, bisabolol, shea butter, and hydrogenated coconut oil in a mass ratio of 0.04:5:4:0.15:0.15:2:2. The skin conditioning agent is composed of camellia seed oil and oat kernel oil in a mass ratio of 0.6:0.4.

[0038] The above face cream was tested as follows: Subjects aged 18-45 years who were in good health and able to complete the test as required (participating voluntarily and signing an informed consent form) were selected. After the lactic acid stinging test, 33 subjects who tested positive for lactic acid stinging were selected (1 male and 32 females). The test temperature was 20.4-21.3℃ and the relative humidity was 41%-48%. The test period was 28 days. During the test, each subject applied an appropriate amount of face cream evenly to the face according to their usual application habits and gently massaged it until absorbed; once in the morning and once in the evening.

[0039] Facial imaging tests (VISIA-CR) were performed on subjects 3 and 9 using a facial image analyzer (Generation 5, Canfield, USA) before and after the experiment. Images showing changes in the facial red zone are shown below. Figure 1 The raw data of a* values ​​of the facial red area analysis of 33 subjects before and after the experiment were statistically analyzed, and the results are shown in Table 4.

[0040] Table 4. Raw data of a* values ​​for red zone analysis.

[0041] The original data of the red zone analysis a* values ​​in Table 4 were statistically analyzed, and the results are shown in Table 5; the significance analysis of the red zone analysis a* values ​​is shown in Table 6.

[0042] Table 5. Descriptive statistics of a* values ​​in the red zone analysis (n = 33)

[0043] Table 6 Statistical analysis results of a* values ​​in the red zone (n = 33)

[0044] Combination Figure 1 The results in Tables 4-6 show that, compared with before use, the a* value of the red area analysis decreased significantly after 28 days of using the test samples. p <0.05). This means the product provided by this invention can be used to relieve skin redness and has a soothing effect.

[0045] In summary, the moisturizing and soothing composition provided by this invention can promote the metabolism of stratum corneum cells, assist in barrier repair, inhibit the release of inflammatory factors, relieve redness and stinging caused by barrier damage, and is suitable for the delicate skin of infants and children.

[0046] Although the above embodiments have provided a detailed description of the present invention, they are only some embodiments of the present invention, and not all embodiments. People can obtain other embodiments based on these embodiments without creative effort, and these embodiments all fall within the protection scope of the present invention.

Claims

1. A moisturizing and soothing composition containing sodium hyaluronate, characterized in that, By weight, it includes the following raw materials: Sodium hyaluronate 0.01-0.05 parts, moisturizing ingredients 5-25 parts, soothing ingredients 0.01-0.7 parts, and skin-moisturizing ingredients 0.1-6 parts; The moisturizing ingredients include at least one of glycerin, 1,3-butanediol, and 1,3-propanediol; The soothing ingredients include at least one of allantoin, bisabolol and gentian root extract; The moisturizing ingredients include shea butter and / or hydrogenated coconut oil.

2. The moisturizing and soothing composition according to claim 1, characterized in that, When the moisturizing ingredients consist of glycerin and 1,3-butanediol, the mass ratio of glycerin to 1,3-butanediol is 3-18:2-4. When allantoin and gentian root extract are used as the soothing ingredients, the mass ratio of allantoin to gentian root extract is 0.1:0.

06. When bisabolol and gentian root extract are used to form a soothing ingredient, the mass ratio of bisabolol to gentian root extract is 0.1:0.

06. When shea butter and hydrogenated coconut oil are used as moisturizing ingredients, the mass ratio of shea butter to hydrogenated coconut oil is 1-3:1-3.

3. The moisturizing and soothing composition according to claim 1, characterized in that, By weight, it includes the following raw materials: Sodium hyaluronate 0.05 parts, moisturizing ingredients 9 parts, soothing ingredients 0.7 parts, and skin-nourishing ingredients 3 parts; The moisturizing ingredient is composed of glycerin and 1,3-butanediol in a mass ratio of 5:

4. The soothing ingredients consist of allantoin, bisabolol, and gentian root extract in a mass ratio of 0.5:0.1:0.

1. The moisturizing ingredient is hydrogenated coconut oil.

4. The moisturizing and soothing composition according to any one of claims 1-3, characterized in that, The preparation method of the gentian root extract includes: The plant sample, endoglucanase, and water were ultrasonically mixed to obtain a mixture. The mixture and brewer's yeast were subjected to aerobic fermentation, solid-liquid separation, and concentration and drying to obtain gentian root extract.

5. The moisturizing and soothing composition according to claim 4, characterized in that, During ultrasonic mixing, the mass ratio of the plant sample, endoglucanase, and water is 10-20:1-5:80-90; The ultrasonic mixing temperature is 43-48℃, the time is 3-5h, and the power is 350-500w.

6. The moisturizing and soothing composition according to claim 4, characterized in that, During aerobic fermentation, the mass ratio of the mixture to brewer's yeast is 100:6-10; The effective viable count of the brewer's yeast is ≥1.5×10⁻⁶. 7 cfu / g; The aerobic fermentation is carried out at a temperature of 35-39℃ for 36-48 hours.

7. The use of the moisturizing and soothing composition according to any one of claims 1-6 in the preparation of infant skin care products.

8. The application according to claim 7, characterized in that, The products include: body lotion or face cream.

9. A face cream specifically for infants and children, characterized in that, The baby-specific face cream includes: the moisturizing and soothing composition according to any one of claims 1-6.

10. The baby-specific face cream according to claim 9, characterized in that, By weight, it includes the following raw materials: The moisturizing and soothing composition according to any one of claims 1-6 comprises 13.34 parts of a thickener, 1.2 parts of a thickener, 5 parts of an emulsifier, 2.0 parts of a skin conditioning agent, 0.1 parts of a fragrance, and 78.36 parts of water.

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