Ultrasonic irradiation device

Abstract

The application discloses an ultrasonic irradiation device, and relates to the technical field of ultrasonic irradiation equipment, which comprises an irradiation mechanism, an adjusting mechanism and a treatment area, wherein the ultrasonic emission end of the irradiation mechanism is located below a to-be-tested object; the adjusting mechanism is used for bearing the to-be-tested object and can adjust the position of the to-be-tested object according to the lesion depth inside the to-be-tested object, so that the lesion area of the to-be-tested object is coincident with the focal point of the irradiation mechanism; and the treatment area is used for containing the to-be-tested object and a coupling agent arranged between the ultrasonic emission end and the to-be-tested object; the treatment area has a boundary, and the boundary is used for limiting the flow of the coupling agent, so that the coupling agent accumulates and contacts the to-be-tested object. The application improves the treatment gain of stimulation and improves the safety and reliability of treatment.

Description

Technical Field

[0001] This invention relates to the field of ultrasonic irradiation equipment technology, and in particular to an ultrasonic irradiation device. Background Technology

[0002] In the field of modern medical research, ultrasound technology, with its advantages of being non-invasive, safe, and having strong tissue penetration, has gradually expanded from imaging diagnosis to becoming an important treatment method. The clinical translation and promotion of ultrasound technology depends on in-depth preclinical research, which means that the demand for specialized scientific research ultrasound irradiation equipment is also increasing.

[0003] In existing animal ultrasound irradiation experiments, top-mounted ultrasound equipment is typically used, where the ultrasound probe is positioned above the test subject (e.g., a mouse), which is placed in a fixed slot below. To achieve effective in vivo irradiation, the probe height needs to be adjusted according to the lesion depth to ensure the ultrasound focus coincides with the target area. However, ultrasound probes have a fixed physical focal length, and adjusting the probe height inevitably changes the distance between the probe and the test subject surface. To compensate for this distance and ensure acoustic coupling, a large amount of coupling agent must be filled between the probe and the test subject. Coupling agents are often liquid or gel-like, and their volume increases significantly with probe height. For small animals (especially mice), excessive coupling agent can easily overwhelm their mouth and nose, leading to suffocation or even death. Therefore, this method cannot accurately align the focus of the ultrasound probe with the in vivo lesion area for test subjects with lesions of varying depths. Energy cannot be effectively concentrated on the diseased tissue, reducing the therapeutic gain of the stimulation and potentially causing unnecessary deposition of acoustic energy in non-target tissues due to focus deviation, leading to secondary damage. Summary of the Invention

[0004] The purpose of this invention is to provide an ultrasound irradiation device to solve the problems existing in the prior art, improve the therapeutic gain of stimulation, and enhance the safety and reliability of treatment.

[0005] To achieve the above objectives, the present invention provides the following solution: This invention provides an ultrasonic irradiation device, characterized in that it comprises: an irradiation mechanism, an adjustment mechanism, and a treatment area; the ultrasonic emitting end of the irradiation mechanism is located below the object to be tested; the adjustment mechanism is used to support the object to be tested and can adjust the position of the object to be tested according to the depth of the lesion inside the object to be tested, so that the lesion area of ​​the object to be tested coincides with the focal point of the irradiation mechanism; the treatment area is used to accommodate the object to be tested and a coupling agent disposed between the ultrasonic emitting end and the object to be tested; the treatment area has a boundary, the boundary being used to restrict the flow of the coupling agent, so that the coupling agent accumulates and contacts the object to be tested.

[0006] In one embodiment, the adjustment mechanism includes a clamping member for fixing the object to be tested and an orientation adjustment member for adjusting the posture and position; the orientation adjustment member is connected to the clamping member; the clamping member positions the object to be tested toward the irradiation mechanism, and the orientation adjustment member drives the clamping member to move so that the object to be tested fits tightly against the coupling agent and the focal point of the irradiation mechanism coincides with the lesion area in the object to be tested.

[0007] In one embodiment, the orientation adjustment component includes a lifting adjustment component, a steering adjustment component, a horizontal adjustment component, and a universal adjustment component; the clamping component is disposed at the free end of the universal adjustment component; the universal adjustment component is disposed at the free end of the horizontal adjustment component; the horizontal adjustment component is disposed at the free end of the steering adjustment component; and the steering adjustment component is disposed at the free end of the lifting adjustment component.

[0008] In one embodiment, the system further includes a housing, with the treatment area located inside the housing. The ultrasonic transmitter is located either inside or outside the treatment area. When located outside the treatment area, the ultrasonic energy emitted by the ultrasonic transmitter can pass through the bottom structure of the treatment area and enter the treatment area. The lifting adjustment component includes a lifting actuator and a lifting control mechanism. The lifting actuator is located in the treatment area, and the lifting control mechanism is located outside the treatment area. The lifting control mechanism controls the lifting actuator to move up and down. The steering adjustment component is located at the free end of the lifting actuator.

[0009] In one embodiment, the steering adjustment member includes a connecting rod and a first locking member; the connecting rod is rotatably disposed at the free end of the transmission lifting member, and the first locking member can lock the posture of the connecting rod or unlock it to allow the connecting rod to rotate.

[0010] In one embodiment, the leveling member includes a limiting groove, a moving rod, and a second locking member. The limiting groove is formed on the connecting rod, and the moving rod is slidably disposed on the limiting groove. The second locking member can lock the moving rod or unlock it to allow the moving rod to move. The moving rod is the free end of the leveling member.

[0011] In one embodiment, the universal adjustment component includes a connecting rod, a universal ball housing, a damping element, a universal ball head, and a third locking element; the connecting rod is detachably connected to the moving rod, and the universal ball housing is fixed to the end of the connecting rod away from the moving rod; the universal ball head is assembled on the clamping element; the universal ball head is located inside the universal ball housing, the damping element is clamped between the mating surfaces of the universal ball housing and the universal ball head, and the third locking element can lock the universal ball head or release the universal ball head to allow the universal ball head to rotate; the universal ball head is the free end of the universal adjustment component.

[0012] In one embodiment, the clamping member includes a clamping plate and a clamping assembly; the clamping assembly is disposed on the side of the clamping plate facing the irradiation mechanism and is used to fix the object to be tested.

[0013] In one embodiment, the device further includes an anesthesia component and a measurement component; the anesthesia component is disposed on a clamping plate and is used to continuously supply anesthetic to the test subject during treatment; the measurement component includes a temperature sensor and a blood oxygen and heart rate sensor for real-time detection of the status of the test subject.

[0014] In one embodiment, the enclosure is equipped with a removable top cover and an observation window, and a main unit is detachably mounted on the enclosure. The main unit is in signal communication with the measuring component and the irradiation mechanism.

[0015] The present invention achieves the following technical effects compared to the prior art: This invention discloses an ultrasonic irradiation device. The ultrasonic transmitter of the irradiation mechanism is located below the test object, and the coupling agent is located between the ultrasonic transmitter and the test object, i.e., the coupling agent is located below the test object. Since the test object is a living organism and is located above the coupling agent, the amount of coupling agent is not limited by the presence of the test object. At the same time, the boundary of the treatment area can restrict the flow of the coupling agent, causing it to accumulate until it contacts the test object. By adjusting the mechanism to regulate the relative position between the test object and the ultrasonic transmitter, lesions of different depths can be precisely aligned with the irradiation focus, thereby flexibly adapting to the treatment needs of lesions of different depths. Therefore, the irradiation mechanism can achieve directional convergence of ultrasonic energy to the lesion tissue, enhance the effect of ultrasonic irradiation or stimulation, avoid sound energy dispersion and damage to non-target tissues caused by focus deviation, and improve the safety and reliability of animal experiments. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 This is a schematic diagram of one embodiment of the ultrasonic irradiation device of the present invention; Figure 2 This is a schematic diagram of the adjustment mechanism of the ultrasonic irradiation device of the present invention; Figure 3 This is a cross-sectional view of the lifting adjustment component and the steering adjustment component of the ultrasonic irradiation device of the present invention; Figure 4 This is a cross-sectional view of the horizontal adjustment component of the ultrasonic irradiation device of the present invention; Figure 5 This is a cross-sectional view of the universal adjustment component of the ultrasonic irradiation device of the present invention; Figure 6 This is a cross-sectional view of the anesthesia component of the ultrasonic irradiation device of the present invention; Figure 7 This is a schematic diagram of the clamping plate of the ultrasonic irradiation device of the present invention; In the diagram: 1. Power component; 2. Base; 3. Lifting rod; 4. Connecting rod; 5. Locking block; 6. Connecting rod; 7. Clamping plate; 8. Air agitation device; 9. Housing; 10. Moving rod; 11. Main unit; 21. First bevel gear; 22. First bearing; 31. Second bevel gear; 32. Second bearing; 41. Friction pad; 42. Anti-loosening pad; 43. First locking component; 51. Second locking component; 61. Third locking element; 62. Damping element; 63. Magnetic block; 71. Slider; 72. Adjusting screw; 73. Support plate; 74. Sponge pad; 75. Velcro; 76. Binding post; 81. Air inlet hose; 82. Air paralysis mask; 83. Air outlet hose; 84. Sealing sleeve; 91. Box lid; 92. Scale; 93. Irradiation mechanism; 94. Observation window; 101. Magnetic groove; 111. Temperature sensor; 112. Blood oxygen and heart rate sensor. Detailed Implementation

[0018] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0019] The purpose of this invention is to provide an ultrasound irradiation device to solve the problems existing in the prior art, improve the therapeutic gain of stimulation, and enhance the safety and reliability of treatment.

[0020] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0021] like Figure 1-7 As shown, the present invention provides an ultrasound irradiation device, including an irradiation mechanism 93, an adjustment mechanism, and a treatment area. The ultrasound emitting end of the irradiation mechanism 93 is located below the object to be tested. The adjustment mechanism is used to support the object to be tested and can adjust the position of the object to be tested according to the depth of the lesion inside the object to be tested, so that the lesion area of ​​the object to be tested coincides with the focal point of the irradiation mechanism 93. The treatment area is used to accommodate the object to be tested and a coupling agent disposed between the ultrasound emitting end and the object to be tested. The treatment area has a boundary, which is used to restrict the flow of the coupling agent so that the coupling agent accumulates and contacts the object to be tested.

[0022] The ultrasonic transmitter of the irradiation device 93 is located below the test object, and the coupling agent is located between the ultrasonic transmitter and the test object, i.e., the coupling agent is below the test object. Since the test object is a living organism and located above the coupling agent, the amount of coupling agent used is not limited by the presence of the test object. Simultaneously, the boundary of the treatment area restricts the flow of the coupling agent, causing it to accumulate until it contacts the test object. By adjusting the relative position between the test object and the ultrasonic transmitter, lesions of different depths can be precisely aligned with the irradiation focus, thus flexibly adapting to the treatment needs of lesions at different depths. Therefore, the irradiation device 93 can achieve directional focusing of ultrasonic energy onto the lesion tissue, enhancing the effect of ultrasonic irradiation or stimulation, avoiding sound energy dispersion and damage to non-target tissues caused by focus deviation, and improving the safety and reliability of animal experiments.

[0023] In one embodiment, the adjustment mechanism includes a clamping member for fixing the object to be tested and an orientation adjustment member for adjusting the posture and position; the orientation adjustment member is connected to the clamping member; the clamping member sets the object to be tested toward the irradiation mechanism 93, and the orientation adjustment member drives the clamping member to move so that the object to be tested fits tightly against the coupling agent and the focal point of the irradiation mechanism 93 coincides with the lesion area in the object to be tested.

[0024] In this embodiment, when the test object has a vertically arranged lesion area, the position of the test object is adjusted to make the focal point of the irradiation mechanism 93 coincide with the lesion area within the test object. When the test object has a non-vertically arranged lesion area, the posture of the test object is adjusted to make the lesion area face the ultrasound waves, so that more ultrasound waves can act on the lesion area and improve the treatment effect.

[0025] The orientation adjustment mechanism provides multi-degree-of-freedom fine-tuning capabilities such as translation, rotation, and pitch, enabling precise alignment of the focal point of the irradiation unit 93 with the lesion area at any spatial location within the object being tested. This ensures that the treatment or detection energy is accurately applied to the target tissue, avoiding damage to surrounding healthy structures and greatly improving positioning accuracy and therapeutic efficacy.

[0026] In one embodiment, the orientation adjustment component includes a lifting adjustment component, a steering adjustment component, a horizontal adjustment component, and a universal adjustment component; a clamping component is disposed at the free end of the universal adjustment component; the universal adjustment component is disposed at the free end of the horizontal adjustment component; the horizontal adjustment component is disposed at the free end of the steering adjustment component; and the steering adjustment component is disposed at the free end of the lifting adjustment component.

[0027] This embodiment provides an implementation method for an orientation adjustment component.

[0028] In one embodiment, the device further includes a housing 9, with the treatment area located inside the housing 9. The ultrasonic transmitter is located either inside or outside the treatment area. When located outside the treatment area, the ultrasonic energy emitted by the ultrasonic transmitter can pass through the bottom structure of the treatment area and enter the treatment area. The lifting adjustment component includes a lifting actuator and a lifting control mechanism. The lifting actuator is located in the treatment area, and the lifting control mechanism is located outside the treatment area. The lifting control mechanism controls the lifting actuator to lift. A steering adjustment component is disposed at the free end of the lifting actuator.

[0029] The enclosure in this embodiment is designed to create a treatment area to confine the coupling agent. During experiments, to maintain the closed state of the treatment area (e.g., to prevent coupling agent spillage or external contamination), the treatment area is typically sealed using a removable cover 91 on the enclosure. However, this application places the lifting control mechanism outside the treatment area and the lifting actuator inside the treatment area to facilitate control of the lifting actuator's movement without opening the enclosure during experiments.

[0030] The lifting adjustment component includes a power component 1, a base 2, a lifting rod 3, a first bevel gear 21, a second bevel gear 31, a rotating component, a first bearing 22, and a second bearing 32. The power component 1 is rotatably mounted on the outside of the housing 9 via the first bearing 22, and the output end of the power component 1 extends into the housing 9 and is fixedly connected to the first bevel gear 21. The base 2 is fixedly installed inside the housing 9, and the lifting rod 3 is vertically slidably mounted on the base 2. The second bearing 32 is installed inside the base 2, and the rotating component is rotatably mounted inside the base 2 via the second bearing 32. The rotating component has an external thread on its outer side, and the second bevel gear 31 is fixedly sleeved on the rotating component. A connecting block with an internal thread is fixedly installed inside the lifting rod 3. The first bevel gear 21 and the second bevel gear 31 mesh with each other, and the external thread of the rotating component is threadedly engaged with the internal thread of the connecting block. The power component 1 is driven to rotate the rotating component through the first bevel gear 21 and the second bevel gear 31, and then drives the lifting rod 3 to move up and down relative to the base 2 through the threaded transmission. The lifting rod 3 is the free end of the lifting adjustment component.

[0031] The power component 1, such as a knob or motor, is mounted on the outside of the housing 9. Its output shaft extends into the housing 9 via the first bearing 22, while the lifting actuator base 2, lifting rod 3, rotating components, etc., are entirely located inside the treatment area of ​​the housing 9. The output shaft of the power component 1 is typically horizontal to facilitate operation from the side of the housing 9. Through the meshing of the first bevel gear 21 and the second bevel gear 31, horizontal rotation is converted into vertical rotation, driving the vertical screw of the rotating component to rotate. The operator can drive the lifting without opening the housing 9, avoiding air disturbance or coupling agent contamination introduced during ultrasonic irradiation, and preventing accidental ultrasonic exposure of the operator. The internal and external threads are trapezoidal drive threads, providing a larger contact area and higher torque transmission capacity, as well as strong fatigue resistance and transmission self-locking properties.

[0032] In one specific implementation, the power component 1 can be a manual knob with a scale of 92 or a stepper motor. The manual mode is suitable for low-cost, low-frequency adjustments, allowing for precise control of the experimental animal's height according to the scale of 92; the motor mode enables programmed automatic lifting and lowering. When using a dedicated manual knob, a pointer is provided, and raised edges are added to increase friction during rotation by the operator, enhancing operational control.

[0033] In one embodiment, the steering adjustment member includes a connecting rod 4 and a first locking member 43; the connecting rod 4 is rotatably disposed at the free end of the transmission lifting member, and the first locking member 43 can lock the posture of the connecting rod 4, or unlock it to allow the connecting rod 4 to rotate.

[0034] Link 4 is installed at the free end of lifting rod 3. During operation, the lifting height can be adjusted independently first to bring the lesion basically into the focal plane of the emission energy of the irradiation mechanism 93, and then the position of link 4 can be adjusted separately to align with the direction of the sound beam axis. The lifting action will not affect the set angle of link 4, and conversely, rotating link 4 will not change the lifting height. The two degrees of freedom are completely decoupled, which greatly reduces the complexity of operation and avoids repeated corrections.

[0035] In one specific embodiment, the connecting rod 4 has a through hole, and the first locking element 43 is a locking nut. The locking nut has a rotating locking arrow to facilitate the rotation locking operation by the experimenter. The through hole passes through the upper part of the lifting rod 3 and can rotate to be located on the upper part of the lifting rod 3. The upper part of the lifting rod 3 is provided with a thread, and the thread profile is a triangular connecting thread. The upper part of the lifting rod 3 and the locking nut are connected and engaged by the thread. The lifting rod 3 and the connecting rod 4 are fitted with a friction washer 41 with clearance. The friction washer 41 is made of rubber to reduce the wear of the connecting rod 4 during rotation and increase the damping during movement. The lifting rod 3, the connecting rod 4, and the locking nut are fitted with an anti-loosening washer 42 with clearance. The anti-loosening washer 42 is made of stainless steel to prevent the locking nut from loosening and increase the reliability of the fixation.

[0036] In one embodiment, the horizontal adjustment member includes a limiting groove, a moving rod 10, and a second locking member 51. The limiting groove is formed on the connecting rod 4, and the moving rod 10 is slidably disposed on the limiting groove. The second locking member 51 can lock the moving rod 10 or unlock it to allow the moving rod 10 to move. The moving rod 10 is the free end of the horizontal adjustment member.

[0037] The moving rod 10 can slide back and forth horizontally within the limiting groove, allowing the clamping member to move in a plane relative to the focal point of the irradiation mechanism 93. After the lifting height and the rotation angle of the connecting rod 4 are initially set, fine adjustments are often needed in the horizontal direction to ensure that the center of the lesion falls precisely on the vertical projection point of the ultrasound focal point. This horizontal adjustment component provides this crucial degree of freedom, compensating for the inability of the first two stages of adjustment (lifting and turning) to achieve horizontal translation.

[0038] In one specific embodiment, the connecting rod 4 has symmetrically provided limiting grooves. The moving rod 10 consists of a main rod, a locking block 5, and two connecting posts. The upper part of the main rod has a connecting groove, and the upper part of the main rod is fixedly connected to the locking block 5. Connecting posts are fixedly connected to both sides of the connecting groove, and the connecting posts are slidably disposed in the limiting groove. The connecting rod 4 passes through the space between the main rod and the locking block 5. A circular hole is provided above the locking block 5, and a locking screw passes through the circular hole. A nut is fixedly connected to the locking block 5 and is coaxial with the circular hole. A rubber cap is fixedly connected to one end of the locking screw that extends into the locking block 5, and a rotary button is fixedly connected to the other end of the locking screw that extends out of the locking block 5. The rotary button facilitates the experimenter to perform a rotation locking operation. Tightening the locking screw causes the rubber cap to press against the connecting rod 4, thereby locking the sliding position of the moving rod 10. Tightening the locking screw causes the rubber cap to move away from the connecting rod 4, thereby releasing the sliding position of the moving rod 10.

[0039] In one embodiment, the universal adjustment component includes a connecting rod 6, a universal ball housing, a damping element 62, a universal ball head, and a third locking element 61; the connecting rod 6 is detachably connected to the moving rod 10, and the universal ball housing is fixed to the end of the connecting rod 6 away from the moving rod 10; the universal ball head is assembled on the clamping element; the universal ball head is located inside the universal ball housing, the damping element 62 is clamped between the mating surfaces of the universal ball housing and the universal ball head, and the third locking element 61 can lock the universal ball head or release the universal ball head to allow the universal ball head to rotate, and the universal ball head is the free end of the universal adjustment component.

[0040] The universal joint can rotate in any direction within the universal ball housing, including three rotational degrees of freedom: pitch, yaw, and roll. This allows the clamping element to be precisely aligned at any angle relative to the axis of the irradiation mechanism 93. The universal joint compensates for the remaining degrees of attitude freedom. When the test object has a non-vertically arranged lesion area, the attitude of the test object can be adjusted so that the lesion area is directly facing the ultrasound waves, allowing more ultrasound waves to act on the lesion area and improving the treatment effect.

[0041] In one specific embodiment, a magnetic groove 101 is provided below the moving rod 10, and a magnetic block 63 is provided at one end of the connecting rod 6, so that the clamping part can be disassembled from the whole device, making it convenient for the experimenter to operate.

[0042] In one specific embodiment, the damping element 62 is made of rubber, which increases the damping of the universal joint adjustment component, making angle adjustment more reliable. The universal ball housing has threaded holes, and the third locking element 61 is a locking screw. The locking screw engages with the universal ball housing via a threaded connection. A rotating button is located on the upper part of the locking screw, and a plastic cap is located on the lower part. The shape of the plastic cap tightly conforms to the curved surface of the damping element 62, and the plastic cap presses against the damping element 62 to lock the universal joint.

[0043] In one embodiment, the clamping member includes a clamping plate 7 and a clamping assembly; the clamping assembly is disposed on the side of the clamping plate 7 facing the irradiation mechanism 93 and is used to fix the object to be tested.

[0044] The clamping assembly includes a first sliding groove, a slider 71, an adjusting screw 72, a support plate 73, a sponge pad 74, Velcro 75, and a binding post 76, all mounted on the clamping plate 7. The first sliding groove is configured in two sets. The slider 71 has protrusions at both ends and moves and is fixed by friction through the first sliding groove. The support plate 73 is fixed to the slider 71 by the adjusting screw 72, which is threaded onto the slider 71. The adjusting screw 72 has a rotating button for easy adjustment of the support plate 73, providing support for the test object. A sponge pad 74 is placed inside the support plate 73 to increase the comfort of the test object. The slider 71 slides in the first sliding groove to adjust the position of the support plate 73, preventing the support plate 73 from obstructing the irradiated area. The clamping plate 7 has Velcro 75 and a binding post 76. The soft fiber side of the Velcro 75 contacts the test object, while the barbed elastic fiber side avoids the test object, preventing additional damage. Thin ropes are wrapped around the binding post 76, and the limbs of the object to be tested are bound by the thin ropes to achieve double fixation of the object to be tested.

[0045] In one embodiment, the device further includes an anesthesia component and a measurement component; the anesthesia component is disposed on the clamping plate 7 and is used to continuously supply anesthetic to the test object during treatment; the measurement component includes a temperature sensor 111 and a blood oxygen and heart rate sensor 112, and is used to detect the status of the test object in real time.

[0046] The anesthesia assembly includes a gas anesthesia device 8. Both ends of the gas anesthesia device 8 are connected to an inlet hose 81 and an outlet hose 83 via a sealing sleeve 84. The inlet hose 81 and the outlet hose 83 are made of polyolefin elastomer. A gas anesthesia mask 82 is provided on the gas anesthesia device 8. The gas anesthesia mask 82 is made of silicone. A second sliding groove is also provided on the clamping plate 7. The gas anesthesia device 8 is movably mounted on the second sliding groove. The movement of the gas anesthesia device 8 on the second sliding groove achieves a tight fit between the gas anesthesia mask 82 and the object to be tested, preventing leakage of the gas anesthetic.

[0047] Temperature sensor 111 and blood oxygen and heart rate sensor 112 can monitor the animal's vital signs in real time. Temperature sensor 111 can be an NTC temperature sensor 111 module wrapped in epoxy resin, and blood oxygen and heart rate sensor 112 can be a blood oxygen and heart rate sensor 112 module of model MAX30102.

[0048] In one embodiment, the housing 9 is equipped with a removable top cover and an observation window 94. The irradiation mechanism 93, the receiving plate, and the adjustment mechanism are disposed inside the housing 9. The main unit 11 is detachably installed on the housing 9. The main unit 11 is in signal communication with the measurement components and the irradiation mechanism 93.

[0049] The front of the enclosure 9 is equipped with an observation window 94 for real-time observation of the experimental animals. The top of the enclosure 9 is equipped with a detachable top cover for easy adjustment of the steering adjustment component, the horizontal adjustment component, and the universal adjustment component. The main unit 11 is detachable to adapt to different enclosures 9, saving experimental costs.

[0050] Working principle: Remove the universal ball-shaped rod from the moving rod 10. Move the air-anesthesia device 8 along the second slide groove to the edge of the clamping plate 7, and move the support plate 73 to both ends of the second slide groove. Place the object to be tested on the clamping plate 7, with the part to be irradiated facing the support plate 73 in the center. Fix the object to be tested by first binding the limbs of the object to be tested firmly with the thin rope on the binding post 76, and then reinforcing the limbs and tail of the object to be tested with Velcro 75 to achieve double binding. Move the support plate 73 along the first slide groove to a suitable position to avoid blocking the irradiated part of the object to be tested. Adjust the support plate 73 with the adjusting screw 72 until the sponge pad 74 on the support plate 73 contacts the object to be tested. Move the air-anesthesia device 8 along the second slide groove to cover the head of the object to be tested with the air-anesthesia mask 82. Magnetically fix the connecting rod 6 and the moving rod 10 with the magnetic block 63 and the magnetic groove 101. The clamping plate 7 allows for adjustment of various angles of the test object via a universal joint; the first bevel gear 21 rotates via the rotating power component 1, and the first bevel gear 21 meshes with the second bevel gear 31, driving the second bevel gear 31 to rotate. The second bevel gear 31 is fixedly equipped with a transmission rod, which is connected to the lifting rod 3 via a threaded transmission, allowing the lifting rod 3 to move up and down along the direction of the sliding pair of the base 2; after the position is adjusted, it is fixed by the first locking component 43, the second locking component 51, and the third locking component 61. During irradiation, the irradiation depth of the irradiated part can be precisely adjusted by rotating the power component 1 according to the scale 92; the clamp inside the box 9 is embedded with a temperature sensor 111 and a blood oxygen and heart rate sensor 112, which can be fixed to the animal's body surface during the experiment to achieve real-time, in-vivo monitoring of vital signs; the main unit 11 and the box 9 are connected by a stable electrical connection to control the ultrasonic irradiation parameters.

[0051] Specific examples have been used to illustrate the principles and implementation methods of this invention. The descriptions of the above embodiments are only for the purpose of helping to understand the method and core ideas of this invention. Furthermore, those skilled in the art will recognize that, based on the ideas of this invention, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of this invention.

Claims

1. An ultrasonic irradiation device, characterized in that: include: The irradiation apparatus has its ultrasonic emitting end located below the object being tested. An adjustment mechanism is used to support the test object and can adjust the position of the test object according to the depth of the lesion inside the test object so that the lesion area of ​​the test object coincides with the focal point of the irradiation mechanism; as well as The treatment area is used to accommodate the test object and the coupling agent disposed between the ultrasound transmitter and the test object; The treatment area has a boundary that restricts the flow of the coupling agent, allowing the coupling agent to accumulate and contact the test object.

2. The ultrasonic irradiation device according to claim 1, characterized in that: The adjustment mechanism includes a clamping member for fixing the object to be tested and an orientation adjustment member for adjusting the posture and position; the orientation adjustment member is connected to the clamping member; the clamping member sets the object to be tested toward the irradiation mechanism, and the orientation adjustment member drives the clamping member to move so that the object to be tested is in close contact with the coupling agent and the focal point of the irradiation mechanism coincides with the lesion area in the object to be tested.

3. The ultrasonic irradiation device according to claim 2, characterized in that: The orientation adjustment components include lifting adjustment components, steering adjustment components, leveling adjustment components, and universal adjustment components; The clamping member is disposed at the free end of the universal adjustment member; The universal adjustment component is located at the free end of the horizontal adjustment component; The horizontal adjustment component is disposed at the free end of the steering adjustment component; The steering adjustment component is located at the free end of the lifting adjustment component.

4. The ultrasonic irradiation device according to claim 3, characterized in that: It also includes a housing, the treatment area is located inside the housing, and the ultrasonic transmitter is located either inside or outside the treatment area. When located outside the treatment area, the ultrasonic energy emitted by the ultrasonic transmitter can pass through the bottom structure of the treatment area and enter the treatment area. The lifting adjustment component includes a lifting actuator and a lifting control mechanism. The lifting actuator is located in the treatment area, and the lifting control mechanism is located outside the treatment area. The lifting control mechanism controls the lifting actuator to lift. The steering adjustment component is located at the free end of the lifting actuator.

5. The ultrasonic irradiation device according to claim 3, characterized in that: The steering adjustment component includes a connecting rod and a first locking member; the connecting rod is rotatably located at the free end of the transmission lifting component, and the first locking member can lock the posture of the connecting rod or unlock it to allow the connecting rod to rotate.

6. The ultrasonic irradiation device according to claim 3, characterized in that: The leveling component includes a limiting groove, a moving rod, and a second locking component. The limiting groove is formed on the connecting rod, and the moving rod is slidably disposed on the limiting groove. The second locking component can lock the moving rod or unlock it to allow the moving rod to move. The moving rod is the free end of the leveling component.

7. The ultrasonic irradiation device according to claim 3, characterized in that: The universal adjustment component includes a connecting rod, a universal ball housing, a damping element, a universal ball head, and a third locking element. The connecting rod is detachably connected to the moving rod, and the universal ball housing is fixed to the end of the connecting rod away from the moving rod. The universal ball head is assembled on the clamping element. The universal ball head is located inside the universal ball housing, and the damping element is clamped between the mating surfaces of the universal ball housing and the universal ball head. The third locking element can lock the universal ball head or release the universal ball head to allow it to rotate. The universal ball head is the free end of the universal adjustment component.

8. The ultrasonic irradiation device according to claim 2, characterized in that: The clamping element includes a clamping plate and a clamping assembly; the clamping assembly is located on the side of the clamping plate facing the irradiation mechanism and is used to fix the object to be tested.

9. The ultrasonic irradiation device according to claim 1, characterized in that: It also includes an anesthesia component and a measurement component; the anesthesia component is mounted on the clamping plate and is used to continuously supply anesthetic to the test subject during treatment; the measurement component includes a temperature sensor and a blood oxygen and heart rate sensor, which are used to detect the status of the test subject in real time.

10. The ultrasonic irradiation device according to claim 1, characterized in that: The enclosure is equipped with a removable top cover and an observation window. The main unit is detachably mounted on the enclosure, and the main unit is connected to the measuring components and the irradiation mechanism via signals.

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