Protein purification column storage box

Abstract

A protein purification column storage box comprises a box body, a bottom plate, an upper clamping unit and a lower clamping unit. The multiple bottom plates are arranged in the box body, controllers are arranged in the bottom plates, circular cavities are formed in the centers of the bottom plates, multiple pressure switches electrically connected with the controllers are arranged on the inner circumferential sides of the circular cavities in an array mode, multiple vertical plates are arranged at the upper ends of the bottom plates, and sleeves are arranged on one side faces of the vertical plates. The upper clamping units are arranged on the bottom plates respectively, each upper clamping unit comprises a plurality of sliding blocks which are in sliding fit with the corresponding sleeve, a spring is arranged at one end of each sliding block, the other end of each spring is fixed to the side face of the corresponding vertical plate, a movable mechanism is arranged on each sliding block, and a clamping block used for clamping the upper portion of the protein purification column is arranged at one end of each movable mechanism. The number of the lower clamping units is multiple, each lower clamping unit comprises a pair of semi-circular-ring clamps assembled into a circular ring, and a balancing weight is arranged at the lower end of each semi-circular-ring clamp. According to the protein purification column storage box, the protein purification columns can be more stably and vertically stored, and the overall inclination angle of the box body can be prevented from being too large during transferring.

Description

Technical Field

[0001] The utility model relates to the technical field of storage and transfer of protein purification columns, in particular to a storage box for protein purification columns. Background Art

[0002] When performing protein separation, purification and determination, a protein purifier is required, and the key component of the protein purifier is the protein purification column, which is roughly cylindrical and has a variable diameter portion at the upper and lower ends. When conducting an experiment, if the experiment requires the simultaneous purification of multiple samples, or the effects under different purification conditions need to be compared, multiple protein purification columns must be prepared, so sometimes multiple protein purification columns need to be stored or transferred.

[0003] The protein purification column is filled with specific chromatographic media, such as gel or resin. These media can maintain stable structure and performance when vertical. If tilted, it may cause uneven distribution, compaction or deformation of the media, thus affecting the separation effect and performance of the column. Therefore, it is necessary to keep the protein purification column in a vertical state as much as possible during storage and transfer. Utility Model Content

[0004] In view of the above-mentioned defects, the utility model provides a protein purification column storage box, which can store the protein purification column vertically more stably and avoid the overall tilt angle of the box being too large during transfer.

[0005] In order to achieve the purpose of this utility model, the following technologies are proposed:

[0006] A protein purification column storage box, comprising a box body, and further comprising:

[0007] Multiple bottom plates are arranged in the box body, a controller is arranged in the bottom plate, a circular cavity is opened in the center of the bottom plate, multiple pressure switches electrically connected to the controller are arranged in an array on the inner circumference of the circular cavity, multiple vertical plates are arranged on the upper end of the bottom plate, and a sleeve is arranged on one side of the vertical plate;

[0008] A plurality of upper clamping units are respectively arranged on each bottom plate, the upper clamping units include a plurality of sliders respectively slidably matched with the sleeves, a spring is arranged at one end of the slider, the other end of the spring is fixed to the side of the vertical plate, a movable mechanism is arranged on the slider, and a clamping block for clamping the upper part of the protein purification column is arranged at one end of the movable mechanism;

[0009] A plurality of lower clamping units are respectively arranged below each upper clamping unit. The lower clamping unit comprises a pair of semicircular ring clamps assembled into a circular ring. A counterweight block is arranged at the lower end of the semicircular ring clamp.

[0010] Furthermore, a communication module is also provided in the base plate.

[0011] Furthermore, the clamping block is made of silicone.

[0012] Furthermore, the movable mechanism includes a first U-shaped portion arranged on the upper end surface of the slider, a first round rod is fixed between the two parallel sides thereof, a first rotating sleeve is sleeved on the outer circumference of the first round rod, a second U-shaped portion is provided at the upper end of the first rotating sleeve, a second round rod is fixed between the two parallel sides thereof, a second rotating sleeve is sleeved on the outer circumference of the second round rod, and a mounting portion for fixing the clamping block is provided at one end of the second rotating sleeve.

[0013] Furthermore, a pair of slots is provided at the cross-sectional end of one semicircular ring clamp, and a pair of insert blocks matching the slots is provided at the cross-sectional end of the other semicircular ring clamp.

[0014] Furthermore, a transverse plate is provided on the outer peripheral side of the semicircular ring clamp, a connecting rope is provided at the lower end of the transverse plate, and a counterweight block is provided at the lower end of the connecting rope.

[0015] The beneficial effects of this technical solution are:

[0016] 1. Protein purification columns of different diameters can be stably stored. The counterweight block of the lower clamping unit can improve the verticality of the protein purification column when the storage box is moved, avoiding affecting the effect and performance of the protein purification column.

[0017] 2. There is a circle of pressure switches inside the bottom plate. If the tilt angle of the box is too large during storage and movement, the protein purification columns may still collide. Therefore, when the angle is too large, it can be detected through the pressure switch to remind the staff to make adjustments in time. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 A stereoscopic view of the bottom plate, the upper clamping unit, and the lower clamping unit of an embodiment of the present application is shown.

[0019] Figure 2 A partial exploded view of an embodiment of the present application is shown.

[0020] Figure 3 A three-dimensional view of the interior of an embodiment of the present application is shown.

[0021] Figure 4 The external overall stereogram of the embodiment of the present application is shown. DETAILED DESCRIPTION

[0022] The technical solution of the present application is further described in detail below in conjunction with the accompanying drawings.

[0023] like Figure 1~Figure 4 A protein purification column storage box shown includes a box body 1, a bottom plate 2, an upper clamping unit 3, and a lower clamping unit 4.

[0024] A box cover 11 is provided at the upper end of the box body 1.

[0025] There are multiple bottom plates 2, which are arranged in the box body 1. A controller and a communication module are arranged in the bottom plate 2. Specifically, the controller adopts PLC, and the communication module can communicate with the staff's mobile phone or computer. A circular cavity is opened in the center of the bottom plate 2 and passes through from top to bottom. A plurality of pressure switches 21 electrically connected to the controller are arranged in an array on the inner circumference of the circular cavity. A plurality of vertical plates 22 are arranged on the upper end of the bottom plate 2, and a sleeve 23 is arranged on one side of the vertical plate 22.

[0026] There are multiple upper clamping units 3, which are respectively arranged on each base plate 2. The upper clamping unit 3 includes multiple sliders 31 that are respectively slidably matched with the sleeve 23. A spring 32 is provided at one end of the slider 31, and the other end of the spring 32 is fixed to the side of the vertical plate 22. A movable mechanism is provided on the slider 31, and a clamping block 38 for clamping the upper part of the protein purification column is provided at one end of the movable mechanism. The clamping block 38 is made of silicone, and the contact surface can be deformed according to the diameter of the protein purification column. Specifically, the movable mechanism includes a first U-shaped portion 33 arranged on the upper end surface of the slider 31, a first round rod 34 is fixed between the two parallel sides of the opposite side surfaces, a first rotating sleeve is sleeved on the outer peripheral side of the first round rod 34, a second U-shaped portion 35 is provided on the upper end of the first rotating sleeve, a second round rod 36 is fixed between the two parallel sides of the opposite side surfaces, a second rotating sleeve is sleeved on the outer peripheral side of the second round rod 36, and a mounting portion 37 for fixing the clamping block 38 is provided at one end of the second rotating sleeve.

[0027] There are multiple lower clamping units 4, which are respectively arranged under each upper clamping unit 3. The lower clamping unit 4 includes a pair of semicircular ring clamps 41 assembled into a circular ring, a cross-sectional end of one semicircular ring clamp 41 is provided with a pair of slots 42, and a cross-sectional end of the other semicircular ring clamp 41 is provided with a pair of plug blocks 43 matching the slots 42. A convex portion extends from the outer peripheral side of the semicircular ring clamp 41, and a horizontal plate 44 is provided on the outer end surface of the convex portion. A connecting rope 45 is provided at the lower end of the horizontal plate 44, and a counterweight block 46 is provided at the lower end of the connecting rope 45. When the protein purification column is clamped and the connecting rope 45 is vertical, the bottom end surface of the counterweight block 46 is always higher than the bottom end surface of the bottom plate 2. Specifically, according to protein purification columns of different diameters, lower clamping units 4 of different sizes can be used, that is, the inner diameters of the semicircular ring clamps 41 are different.

[0028] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A protein purification column storage box, comprising a box body (1), characterized in that: Also includes: A plurality of bottom plates (2) are arranged in the box body (1), a controller is arranged in the bottom plate (2), a circular cavity is opened in the center of the bottom plate (2), a plurality of pressure switches (21) electrically connected to the controller are arranged in an array on the inner circumference of the circular cavity, a plurality of vertical plates (22) are arranged at the upper end of the bottom plate (2), and a sleeve (23) is arranged on one side of the vertical plate (22); A plurality of upper clamping units (3) are respectively arranged on each bottom plate (2), the upper clamping units (3) comprising a plurality of sliders (31) respectively slidably matched with the sleeves (23), a spring (32) is provided at one end of the slider (31), the other end of the spring (32) is fixed to the side of the vertical plate (22), a movable mechanism is provided on the slider (31), and a clamping block (38) for clamping the upper part of the protein purification column is provided at one end of the movable mechanism; A plurality of lower clamping units (4) are respectively arranged below each upper clamping unit (3), and the lower clamping unit (4) comprises a pair of semicircular ring clamps (41) assembled into a circular ring, and a counterweight block (46) is provided at the lower end of the semicircular ring clamp (41).

2. The protein purification column storage box according to claim 1, characterized in that: A communication module is also provided inside the base plate (2).

3. The protein purification column storage box according to claim 1, characterized in that: The clamp block (38) is made of silicone.

4. The protein purification column storage box according to claim 1, characterized in that: The movable mechanism comprises a first U-shaped portion (33) arranged on the upper end surface of the slider (31), a first round rod (34) being fixed between two parallel sides opposite to each other, a first rotating sleeve being sleeved on the outer circumference of the first round rod (34), a second U-shaped portion (35) being arranged on the upper end of the first rotating sleeve, a second round rod (36) being fixed between two parallel sides opposite to each other, a second rotating sleeve being sleeved on the outer circumference of the second round rod (36), and a mounting portion (37) for fixing a clamping block (38) being arranged at one end of the second rotating sleeve.

5. The protein purification column storage box according to claim 1, characterized in that: A pair of slots (42) are provided at the cross-sectional end of one semicircular ring clamp (41), and a pair of insert blocks (43) matching the slots (42) are provided at the cross-sectional end of the other semicircular ring clamp (41).

6. The protein purification column storage box according to claim 1, characterized in that: A transverse plate (44) is provided on the outer peripheral side of the semicircular ring clamp (41), a connecting rope (45) is provided at the lower end of the transverse plate (44), and a counterweight (46) is provided at the lower end of the connecting rope (45).

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