Integrated spray device analysis system

Abstract

Provided herein is a compact and integrated spray device testing system that significantly reduces user error and testing operating time. In some embodiments, the spray testing system may use automation and an integrated mechanical design for actuating and weighing the spray device to improve data collection accuracy and reduce testing time.

Description

INTEGRATED SPRAY DEVICE ANALYSIS SYSTEMCROSS-REFERENCE

[0001] This application claims the benefit of U.S. Provisional Application No. 63 / 642,359, filed May 3, 2024, which is incorporated herein by reference in its entirety.BACKGROUND

[0001] A nasal spray device must be evaluated to determine whether the spray device is operating within regulatory requirements e.g., providing consistent and sufficient spray doses throughout the life of the spray device. The testing process includes various steps of measuring a weight of the spray device, actuating the spray device, and collecting emitted doses of the spray device through the course of actuating the spray device. Each step of the process is repetitive but requires attention to detail which lends itself to user error in recording accurate performance data of spray device. Moreover, due to the multiple different steps and handling of the spray device by the user, the process is lengthy, that often can take upwards of 24 minutes not including time to setup the spray device for testing.SUMMARY

[0002] Provided herein, in some embodiments, is a compact (e.g., lab bench compatible) and integrated spray device testing system that significantly reduces user error and testing operating time. In some embodiments, the spray testing system, described elsewhere herein, may utilize automation and an integrated mechanical design for actuating and weighing the spray device to improve data collection accuracy and reduce testing time. Additionally, by automating the spray device testing process, the individual that would otherwise be required to dedicate his attention to the repetitive lengthy process of spray device testing, may participate in higher level thinking and processing of information that the individual would otherwise not be able to participate in.

[0003] In one aspect, provided herein is a system for collecting an emitted dose of a spray device, comprising: a body comprising one or more mounting interfaces disposed along a curved surface or curved edge of the body, wherein one or more collection vessels are configured to couple to the one or more mounting interfaces, and wherein the one or more collection vessels comprise an opening shaped and sized for receiving a tip of the spray device. In some cases, the system further comprises a cleaning apparatus configured to couple to the one or more mounting interfaces. In some cases, the cleaning apparatus comprises a dabber. In some cases, the system further comprises a waste vessel configured to couple to the one or more mounting interfaces. In some cases, the waste vessel comprises an insert configured to seal between the waste vessel and the spray device when the spray device is emitting a waste dose into the waste vessel. In somecases, the insert is removably coupled to the waste vessel. In some cases, the one or more mounting interfaces comprise a body, wherein the body is configured to transition from a first state to a second state when the one or more collection vessels, the waste vessel, the cleaning apparatus, or any combination thereof, couple to the one or more mounting interfaces. In some cases, the first state comprises a retracted state of the body, and wherein the second state comprises an extended state of the body. In some cases, the system further comprises a sensor configured to detect the first state or the second state of the body. In some cases, the body comprises a circular body. In some cases, the body comprises a dome. In some cases, the system further comprises a motor coupled to the body, wherein the motor is configured to rotate the body to align an input of the one or more collection vessels with an output of the spray device. In some cases, the one or more collection vessels are indexed to receive one or more emitted doses of the spray device at a beginning, middle, or end-of-life stage of the spray device. In some cases, a first plurality of collection vessels of the one or more collection vessels are configured to collect one or more emitted doses of the spray device at the beginning-of-life stage of the spray device, wherein a second plurality of collection vessels of the one or more collection vessels are configured to collect one or more emitted doses of the spray device at the middle-of- life stage of the spray device, and wherein a third plurality of collection vessels of the one or more collection vessels are configured to collect one or more emitted doses of the spray device at the end-of-life stage of the spray device. In some cases, the one or more mounting interfaces comprise a basket. In some cases, the one or more mounting interfaces are removably coupled to the body. In some cases, the one or more collection vessels comprise an input adaptor fluidically coupled to the one or more collection vessels, and wherein the input adaptor is configured to form a seal with the spray device when the spray device emits the dose into the one or more collection vessels. In some cases, the one or more collection vessels are coupled to the one or more mounting interfaces with a transition fit. In some cases, the one or more collection vessels are slidably coupled to the one or more mounting interfaces. In some cases, the spray device comprises a nasal or oral spray device. In some cases, a position of the one or more collection vessels is indexed to receive the emitted dose of the spray device when the spray device is actuated. In some cases, the body is at least partially covered by an enclosure. In some cases, the enclosure comprises a cover configured to seal an interior region of the enclosure from a region outside the enclosure. In some cases, the enclosure comprises one or more fans fluidically coupled to the interior region of the enclosure and the region outside the enclosure. In some cases, the system further comprises one or more processors electrically coupled to the motor. In some cases, the one or more processors provide a signal to the motor to rotate the body to fluidically couple an indexed collection vessel of the one or more indexed collection vessels tothe spray device. In some cases, the one or more mounting interfaces comprise at least about 12 mounting interfaces or at least about 20 mounting interfaces.

[0004] In another aspect, a method for collecting an emitted dose of a spray device is provided, comprising: (a) rotating a body comprising one or more mounting interfaces disposed along a curved surface or edge of the body, wherein one or more collection vessels are coupled to the one or more mounting interfaces; and (b) collecting the emitted dose of the spray device in a collection vessel of the one or more collection vessels. In some cases, a cleaning apparatus is coupled to the one or more mounting interfaces of the body. In some cases, the cleaning apparatus comprises a dabber. In some cases, a waste vessel is coupled to the one or more mounting interfaces. In some cases, the waste vessel comprises an insert configured to seal between the waste vessel and the spray device when the spray device is emitting a waste dose into the waste vessel. In some cases, the insert is removably coupled to the waste vessel. In some cases, the one or more mounting interfaces comprise a body, wherein the body is configured to transition from a first state to a second state when the one or more collection vessels, the waste vessel, the cleaning apparatus, or any combination thereof, couple to the one or more mounting interfaces. In some cases, the first state comprises a retracted state of the body, and wherein the second state comprises an extended state of the body. In some cases, a sensor detects or determines the first state or the second state of the body. In some cases, the body comprises a circular body. In some cases, the body comprises a dome. In some cases, the body is coupled to a motor, wherein the motor rotates the body to align an input of the one or more collection vessels with an output of the spray device. In some cases, the one or more collection vessels are indexed to receive one or more emitted doses of the spray device at a beginning, middle, or end-of-life stage of the spray device. In some cases, a first plurality of collection vessels of the one or more collection vessels are configured to collect one or more emitted doses of the spray device at the beginning-of-life stage of the spray device, wherein a second plurality of collection vessels of the one or more collection vessels are configured to collect one or more emitted doses of the spray device at the middle-of-life stage of the spray device, and wherein a third plurality of collection vessels of the one or more collection vessels are configured to collect one or more emitted doses of the spray device at the end-of-life stage of the spray device. In some cases, the one or more mounting interfaces comprise a basket. In some cases, the one or more mounting interfaces are removably coupled to the body. In some cases, the one or more collection vessels comprise an input adaptor fluidically coupled to the one or more collection vessels, and wherein the input adaptor is configured to form a seal with the spray device when the spray device emits the dose into the one or more collection vessels. In some cases, the one or more collection vessels are coupled to the one or more mounting interfaces with a transition fit.In some cases, the one or more collection vessels are slidably coupled to the one or more mounting interfaces. In some cases, the emitted dose of the spray device is collected in the collection vessel when the collection vessel and the spray device are fluidically coupled. In some cases, the spray device comprises a nasal or oral spray device. In some cases, the body is at least partially covered by an enclosure. In some cases, the enclosure comprises a cover configured to seal an interior region of the enclosure from a region outside the enclosure. In some cases, the enclosure comprises one or more fans fluidically coupled to the interior region of the enclosure and the region outside the enclosure. In some cases, one or more processors are electrically coupled to the motor mechanically coupled to the body. In some cases, the body is rotated by the one or more processors providing a signal to the motor to rotate the body to fluidically couple an indexed collection vessel of the one or more indexed collection vessels to the spray device. In some cases, the one or more mounting interfaces comprise at least about 12 mounting interfaces or at least about 20 mounting interfaces.

[0005] In another aspect, a system for collecting an emitted dose of a spray device is provided, comprising: (a) a body comprising one or more mounting interfaces, wherein one or more collection vessels are coupled to the one or more mounting interfaces, and wherein the one or more collection vessels are configured to collect one or more emitted doses of a spray device; (b) a shaft coupled to the body; (c) a first motor coupled to the shaft configured to rotate the shaft thereby rotating the body; and (d) a second motor coupled to the shaft configured to translate the shaft along an axis perpendicular to a surface of the body thereby translating the body along the axis perpendicular to the surface of the body. In some cases, the shaft comprises a spline shaft. In some cases, the shaft comprises a ball disposed at a surface of the shaft. In some cases, the shaft is translated along the axis perpendicular to the surface of the body when the ball is translated along a curved path of a curved body. In some cases, the curved path comprises a repeating curved path along a curved edge or curved surface of the curved body. In some cases, the curved body comprises a cylindrical cam. In some cases, the cylindrical cam comprises a cam angle of up to about 30 degrees. In some cases, the cylindrical cam is rotated up to about 360 degrees. In some cases, the first motor is coupled to a first pulley coupled to the shaft and wherein the second motor is coupled to a second pulley coupled to the curved body. In some cases, the system further comprises a first sensor configured to determine a rotational position of the first pulley, and a second sensor configured to determine a rotational position of the second pulley. In some cases, the first sensor, the second sensor, or a combination thereof, comprise an optical sensor, an electro-magnetic sensor, or a combination thereof. In some cases, the first pulley comprises a first pulley gear concentric with the shaft, and wherein the second pulley comprises a second pulley gear concentric with the curved body. In some cases, the first pulleygear comprises a first body configured to interrupt an optical path of the first sensor to indicate a rotational position of the first pulley gear, and wherein the second pulley gear comprises a second body configured to interrupt an optical path of the second sensor to indicate a rotational position of the second pulley gear. In some cases, the first motor, the second motor, or a combination thereof, comprise a stepper motor. In some cases, the one or more mounting interfaces are disposed along a curved surface or edge of the body. In some cases, the system further comprises a cleaning apparatus configured to couple to the one or more mounting interfaces. In some cases, the cleaning apparatus comprises a dabber. In some cases, the system further comprises a waste vessel configured to couple to the one or more mounting interfaces. In some cases, the waste vessel comprises an insert configured to seal between the waste vessel and the spray device when the spray device is emitting a waste dose into the waste vessel. In some cases, the insert is removably coupled to the waste vessel. In some cases, the one or more mounting interfaces comprise a body, wherein the body is configured to transition from a first state to a second state when the one or more collection vessels, the cleaning apparatus, the waste vessel, or any combination thereof, couple to the one or more mounting interfaces. In some cases, the first state comprises a retracted state of the body, and wherein the second state comprises an extended state of the body. In some cases, the system further comprises a sensor configured to detect the first state or the second state of the body. In some cases, the body comprises a circular body. In some cases, the body comprises a dome. In some cases, the one or more collection vessels are indexed to receive one or more emitted doses of the spray device at a beginning, middle, or end- of-life stage of the spray device. In some cases, a first plurality of collection vessels of the one or more collection vessels are configured to collect one or more emitted doses of the spray device at the beginning-of-life stage of the spray device, wherein a second plurality of collection vessels of the one or more collection vessels are configured to collect one or more emitted doses of the spray device at the middle-of-life stage of the spray device, and wherein a third plurality of collection vessels of the one or more collection vessels are configured to collect one or more emitted doses of the spray device at the end-of-life stage of the spray device. In some cases, the one or more mounting interfaces comprise a basket. In some cases, the one or more mounting interfaces are removably coupled to the body. In some cases, the one or more collection vessels comprise an input adaptor fluidically coupled to the one or more collection vessels, and wherein the input adaptor is configured to form a seal with the spray device when the spray device emits the dose into the one or more collection vessels. In some cases, the one or more collection vessels are coupled to the one or more mounting interfaces with a transition fit. In some cases, the one or more collection vessels are slidably coupled to the one or more mounting interfaces. In some cases, the spray device comprises a nasal or oral spray device. In some cases, the bodyis at least partially covered by an enclosure. In some cases, the enclosure comprises a cover configured to seal an interior region of the enclosure from a region outside the enclosure. In some cases, the enclosure comprises one or more fans fluidically coupled to the interior region of the enclosure and the region outside the enclosure. In some cases, the system further comprises one or more processors electrically coupled to the first motor or the second motor. In some cases, the one or more processors provide a first signal to the first motor to rotate the body and a second signal to the second motor to translate the body, and wherein the body is rotated and translated to fluidically couple an indexed collection vessel of the one or more indexed collection vessels to the spray device. In some cases, the one or more mounting interfaces comprise at least about 12 mounting interfaces or at least about 20 mounting interfaces.

[0006] In yet another aspect, a method for collecting an emitted dose of a spray device is provided, comprising: (a) rotating a shaft coupled to a body, wherein the body comprises one or more mounting interfaces, wherein one or more collection vessels are coupled to the one or more mounting interfaces; (b) translating the shaft along an axis perpendicular to a surface of the body; and (c) collecting the emitted dose of the spray device when a collection vessel of the one or more collection vessels is fluidically coupled to the spray device. In some cases, the shaft comprises a spline shaft. In some cases, the shaft comprises a ball disposed at a surface of the shaft. In some cases, the shaft is translated along the axis perpendicular to the surface of the body when the ball is translated along a curved path of a curved body. In some cases, the curved path comprises a repeating curved path along a curved edge or curved surface of the curved body. In some cases, the curved body comprises a cylindrical cam. In some cases, the cylindrical cam comprises a cam angle of up to about 30 degrees. In some cases, the cylindrical cam is rotated up to about 360 degrees. In some cases, the shaft is rotated by a first pulley coupled to a first motor, and wherein the shaft is translated by a second pulley coupled to a second motor. In some cases, a rotational position of the first pulley is determined by a first sensor, and wherein a rotational position of the second pulley is determined by a second sensor. In some cases, the first sensor, the second sensor, or a combination thereof, comprise an optical sensor, an electro-magnetic sensor, or a combination thereof. In some cases, the first pulley comprises a first pulley gear concentric with the shaft, and wherein the second pulley comprises a second pulley gear concentric with the curved body. In some cases, the first pulley gear comprises a first body configured to interrupt an optical path of the first sensor to indicate a rotational position of the first pulley gear, and wherein the second pulley gear comprises a second body configured to interrupt an optical path of the second sensor to indicate a rotational position of the second pulley gear. In some cases, the first motor, the second motor, or a combination thereof, comprise a stepper motor. In some cases, the one or more mounting interfaces aredisposed along a curved surface or edge of the body. In some cases, the method further comprises a cleaning apparatus coupled to the one or more mounting interfaces. In some cases, the cleaning apparatus comprises a dabber. In some cases, the method further comprises a waste vessel coupled to the one or more mounting interfaces. In some cases, the waste vessel comprises an insert configured to seal between the waste vessel and the spray device when the spray device is emitting a waste dose into the waste vessel. In some cases, the insert is removably coupled to the waste vessel. In some cases, the one or more mounting interfaces comprise a body, wherein the body is configured to transition from a first state to a second state when the one or more collection vessels, the waste vessel, the cleaning apparatus, or any combination thereof, couple to the one or more mounting interfaces. In some cases, the first state comprises a retracted state of the body, and wherein the second state comprises an extended state of the body. In some cases, a sensor detects or determines the first state or the second state of the body. In some cases, the body comprises a circular body. In some cases, the body comprises a dome. In some cases, the one or more collection vessels are indexed to receive one or more emitted doses of the spray device at a beginning, middle, or end-of-life stage of the spray device. In some cases, a first plurality of collection vessels of the one or more collection vessels are configured to collect one or more emitted doses of the spray device at the beginning-of-life stage of the spray device, wherein a second plurality of collection vessels of the one or more collection vessels are configured to collect one or more emitted doses of the spray device at the middle-of- life stage of the spray device, and wherein a third plurality of collection vessels of the one or more collection vessels are configured to collect one or more emitted doses of the spray device at the end-of-life stage of the spray device. In some cases, the one or more mounting interfaces comprise a basket. In some cases, the one or more mounting interfaces are removably coupled to the body. In some cases, the one or more collection vessels comprise an input adaptor fluidically coupled to the one or more collection vessels, and wherein the input adaptor is configured to form a seal with the spray device when the spray device emits the dose into the one or more collection vessels. In some cases, the one or more collection vessels are coupled to the one or more mounting interfaces with a transition fit. In some cases, the one or more collection vessels are slidably coupled to the one or more mounting interfaces. In some cases, the spray device comprises a nasal or oral spray device. In some cases, the body is at least partially covered by an enclosure. In some cases, the enclosure comprises a cover configured to seal an interior region of the enclosure from a region outside the enclosure. In some cases, the enclosure comprises one or more fans fluidically coupled to the interior region of the enclosure and the region outside the enclosure. In some cases, one or more processors are electrically coupled to the first motor or the second motor. In some cases, the body is rotated by the one or more processors providing a firstsignal to the first motor to rotate the body, wherein the body is translated by the one or more processors providing a second signal to the second motor to translate the body, and wherein the body is rotated and translated to fluidically couple an indexed collection vessel of the one or more indexed collection vessels to the spray device. In some cases, the one or more mounting interfaces comprise at least about 12 mounting interfaces or at least about 20 mounting interfaces.

[0007] In yet another aspect, a system for weighing a spray device is provided, comprising: (a) a collar coupled to the spray device; (b) a lift actuator configured to translate the collar along an axis orthogonal to a surface of the collar; and (c) a weighing module, wherein a surface of the weighing module is coupled to a body, wherein a mass is cantilevered on the body, and wherein the weighing module weighs the spray device when the collar contacts the body. In some cases, the body comprises one or more mounting features configured to contact a surface of the collar. In some cases, the one or more mounting features comprise one or more protrusions disposed on a surface of the body. In some cases, the system further comprises a spray device actuator configured to actuate the spray device thereby emitting a dose of the spray device collected by a collection vessel. In some cases, the spray device is not in contact with the spray device actuator when the weighing module weighs the spray device. In some cases, the spray device is not in contact with the weighing module when the spray device is actuated. In some cases, the system further comprises one or more leveling features configured to level the weighing module. In some cases, the one or more leveling features are adjustable. In some cases, the spray device comprises a nasal or oral spray device. In some cases, the lift actuator comprises one or more bodies, and wherein one or more surfaces of the one or more bodies is configured to couple to one or more surfaces of the collar. In some cases, the mass is cantilevered on a first end of the body opposite a second end of the body where the collar contacts the body. In some cases, the collar comprises a collet. In some cases, the body is at least partially covered by an enclosure. In some cases, the enclosure comprises a cover configured to seal an interior region of the enclosure from a region outside the enclosure. In some cases, the enclosure comprises one or more fans fluidically coupled to the interior region of the enclosure and the region outside the enclosure. In some cases, the weighing module, the lift actuator, the collar, the spray device, or any combination thereof, is at least partially covered by an enclosure. In some cases, the enclosure comprises a cover configured to seal an interior region of the enclosure from a region outside the enclosure. In some cases, the enclosure comprises one or more fans fluidically coupled to the interior region of the enclosure and the region outside the enclosure.

[0008] In yet another aspect, a method for weighing a spray device is provided, comprising: weighing the spray device thereby determining a weight of the spray device when a collarcoupled to the spray device contacts a body coupled to a weighing module, wherein a mass is cantilevered on the body. In some cases, the method further comprises actuating the spray device with a spray device actuator to emit a dose into a collection vessel. In some cases, the spray device is not in contact with the spray device actuator when the weighing module weighs the spray device. In some cases, the spray device is not in contact with the weighing module when the spray device is actuated. In some cases, the body comprises one or more mounting features configured to contact a surface of the collar. In some cases, the one or more mounting features comprise one or more protrusions disposed on a surface of the body. In some cases, the method further comprises translating the collar coupled to the spray device with a lift actuator. In some cases, the lift actuator comprises one or more bodies, and wherein one or more surfaces of the one or more bodies are configured to couple to one or more surfaces of the collar. In some cases, the method further comprises leveling the weighing module with one or more leveling features. In some cases, the one or more leveling features are adjustable. In some cases, the spray device comprises a nasal or oral spray device. In some cases, the mass is cantilevered on a first end of the body opposite a second end of the body where the collar contacts the body. In some cases, the collar comprises a collet. In some cases, the weighing module, the collar, the spray device, the lift actuator, or a combination thereof, is at least partially covered by an enclosure. In some cases, the enclosure comprises a cover configured to seal an interior region of the enclosure from a region outside the enclosure. In some cases, the enclosure comprises one or more fans fluidically coupled to the interior region of the enclosure and the region outside the enclosure.

[0009] In yet another aspect, a system for collecting an emitted dose of a spray device is provided, comprising: one or more processors, and memory storing one or more programs for execution by the one or more processor, the one or more programs comprising instructions to: (i) rotate a body comprising one or more mounting interfaces disposed along a curved surface or edge of the body, wherein one or more collection vessels are coupled to the one or more mounting interfaces; and (ii) collect the emitted dose of the spray device in a collection vessel of the one or more collection vessels. In some cases, a cleaning apparatus is coupled to the one or more mounting interfaces of the body. In some cases, the cleaning apparatus comprises a dabber. In some cases, a waste vessel is coupled to the one or more mounting interfaces. In some cases, the waste vessel comprises an insert configured to seal between the waste vessel and the spray device when the spray device is emitting a waste dose into the waste vessel. In some cases, the insert is removably coupled to the waste vessel. In some cases, the one or more mounting interfaces comprise a body, wherein the body is configured to transition from a first state to a second state when the one or more collection vessels, the waste vessel, the cleaning apparatus, or a combination thereof, couple to the one or more mounting interfaces. In some cases, the firststate comprises a retracted state of the body, and wherein the second state comprises an extended state of the body. In some cases, the system further comprises a sensor configured to detect the first state or the second state of the body. In some cases, the body comprises a circular body. In some cases, the body comprises a dome. In some cases, a motor is coupled to the body, wherein the motor is configured to rotate the body to align an input of the one or more collection vessels with an output of the spray device. In some cases, the one or more collection vessels are indexed to receive one or more emitted doses of the spray device at a beginning, middle, or end-of-life stage of the spray device. In some cases, a first plurality of collection vessels of the one or more collection vessels are configured to collect one or more emitted doses of the spray device at the beginning-of-life stage of the spray device, wherein a second plurality of collection vessels of the one or more collection vessels are configured to collect one or more emitted doses of the spray device at the middle-of-life stage of the spray device, and wherein a third plurality of collection vessels of the one or more collection vessels are configured to collect one or more emitted doses of the spray device at the end-of-life stage of the spray device. In some cases, the one or more mounting interfaces comprise a basket. In some cases, the one or more mounting interfaces are removably coupled to the body. In some cases, the one or more collection vessels comprise an input adaptor fluidically coupled to the one or more collection vessels, and wherein the input adaptor is configured to form a seal with the spray device when the spray device emits the dose into the one or more collection vessels. In some cases, the one or more collection vessels are coupled to the one or more mounting interfaces with a transition fit. In some cases, the one or more collection vessels are slidably coupled to the one or more mounting interfaces. In some cases, the spray device comprises a nasal or oral spray device. In some cases, a position of the one or more collection vessels is indexed to receive the emitted dose of the spray device when the spray device is actuated. In some cases, the body is at least partially covered by an enclosure. In some cases, the enclosure comprises a cover configured to seal an interior region of the enclosure from a region outside the enclosure. In some cases, the enclosure comprises one or more fans fluidically coupled to the interior region of the enclosure and the region outside the enclosure. In some cases, the one or more processors are electrically coupled to a motor mechanically coupled to the body. In some cases, the one or more processors provide a signal to the motor to rotate the body to fluidically couple an indexed collection vessel of the one or more indexed collection vessels to the spray device. In some cases, the one or more mounting interfaces comprise at least about 12 mounting interfaces or at least about 20 mounting interfaces.

[0010] In another aspect, a system for weighing a spray device is provided, comprising: one or more processors, and memory storing one or more programs for execution by the one or moreprocessor, the one or more programs comprising instructions to: (i) contact a collar coupled to the spray device to a surface of a body coupled to a weighing module, wherein a mass is cantilevered on the body; and (ii) weigh the spray device with a weighing module. In some cases, the body comprises one or more mounting features configured to contact a surface of the collar. In some cases, the one or more mounting features comprise one or more protrusions disposed on a surface of the body. In some cases, the instructions further comprise actuate the spray device with a spray device actuator thereby emitting a dose of the spray device collected by a collection vessel. In some cases, the spray device is not in contact with the spray device actuator when the weighing module weighs the spray device. In some cases, the spray device is not in contact with the weighing module when the spray device is actuated. In some cases, the instructions further comprise translate the collar with a lift actuator, wherein the lift actuator comprises one or more bodies, and wherein one or more surfaces of the one or more bodies are configured to couple to one or more surfaces of the collar. In some cases, the body, the weighing module, the spray device actuator, the lift actuator, the spray device, the collar, or any combination thereof, is at least partially covered by an enclosure. In some cases, the enclosure comprises a cover configured to seal an interior region of the enclosure from a region outside the enclosure. In some cases, the enclosure comprises one or more fans fluidically coupled to the interior region of the enclosure and the region outside the enclosure. In some cases, the weighing module comprises one or more leveling features configured to level the weighing module. In some cases, the one or more leveling features are adjustable. In some cases, the spray device comprises a nasal or oral spray device. In some cases, the mass is cantilevered on a first end of the body opposite a second end of the body where the collar contacts the body. In some cases, the collar comprises a collet.INCORPORATION BY REFERENCE

[0011] All publications, patents, and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication, patent, or patent application was specifically and individually indicated to be incorporated by reference.BRIEF DESCRIPTION OF THE DRAWINGS

[0012] The novel features of the invention are set forth with particularity in the appended claims. A better understanding of the features and advantages of the present invention will be obtained by reference to the following detailed description that sets forth illustrative embodiments, in which the principles of the invention are utilized, and the accompanying drawings of which:

[0013] FIGS. 1A-1C show a closed non-transparent view (FIG. 1A), opened view (FIG. IB), and closed transparent view (FIG. 1C) of the spray analysis system, as described in some embodiments herein.

[0014] FIGS. 2A-2E show an apparatus mounting body (FIG. 2A-2B), the interface of the apparatus mounting body to other spray analysis system components (FIG. 2C), and a corresponding indicator mechanism of a mounting receptacle (FIGS. 2D-2E), as described in some embodiments herein.

[0015] FIGS. 3A-3B show a rotation and translation subcomponents of the spray analysis system, as described in some embodiments herein.

[0016] FIGS. 4A-4B show a side perspective view of the curved body and path (FIG. 4A), and a cross-sectional view thereof (FIG. 4B), as described in some embodiments herein.

[0017] FIGS. 5A-5E show various views of the spray analysis system weighing module, spray device actuator, and detailed views thereof, as described in some embodiments herein.

[0018] FIG. 6 shows a workflow diagram for a method of rotating a body coupled to one or more collection devices to collect a dose of a spray device, as described in some embodiments herein.

[0019] FIG. 7 shows a workflow diagram for a method of rotating and translating a body coupled to one or more collection vessels and collecting a dose of a spray device in one or more of the collection vessels, as described in some embodiments herein.

[0020] FIG. 8 shows a workflow diagram for a method of weighing a spray device where the weighing module comprises a cantilevered mass on a body that the spray device is in contact with, as described in some embodiments herein.

[0021] FIG. 9 shows a computer system capable of implementing the methods of the disclosure, as described in some embodiments herein.DETAILED DESCRIPTION

[0022] The systems and / or methods described herein may automatically actuate and / or weigh a spray device to determine a metered dose weight of one or more spray doses of a spray device. In some cases, the automated systems and / or methods, described elsewhere herein, streamline the workflow and / or reduce user error of weighing and / or actuating the spray device otherwise conducted by a human.

[0023] The systems and methods described herein may analyze a weight of a spray device (e.g., a nasal spray device) before and / or after actuation to determine the weight of an emitted spray dose of the spray device. In some cases, weight of the emitted spray dose may comprise a shot weight of spray device and / or a metered spray dose weight. In some cases, the weight of the emittedspray dose of the spray device may be determined at a beginning-of-life, middle-of-life, and / or end-of-life of the spray device. In some instances, the system may collect, acquire, and / or obtain one or more spray doses of the spray device (e.g., at a beginning-of-life, middle-of-life, and / or end-of-life of the spray device), to analyze one or more chemical compounds e.g., concentration(s) of one or more compounds in the collected spray dose. In some cases, the systems and / or methods, described elsewhere herein, through software executed by one or more processors of the system may automate aspects of the spray device analysis and data processing e.g., recording of one or more weight values of the spray device and corresponding number of actuations of the spray device when the one or more weight values of the spray device are acquired. In some cases, the software may comprise one or more user interfaces, where a user may program a series of weighing and / or actuating steps for a spray device to a spray device testing protocol. For example, a user may program the software to conduct a series of weighing, actuating, dose collection, and / or dose wasting steps to conform with various regulatory standards, e.g., European Union uniformity of delivered mass for nasal sprays and the U.S. pharmacopeia (USP) standards for spray device mechanical actuation.Systems

[0024] In some cases, the disclosure provides a system 100 (e.g., a spray analysis system), shown in FIGS. 1A-1C, that may actuate, weigh, and / or collect one or more spray doses of a spray device 126. In some cases, the spray device 126 may comprise a nasal spray device, an oral spray device, or a combination thereof. In some cases, the system may comprise a body 200 configured to couple one or more collection vessels 116, one or more cleaning apparatuses, and / or one or more wasting vessels 118, to one or more mounting interfaces 113 of the body 200, as shown in FIGS. 2A-2E. In some cases, the body 200 may comprise a circular structure. In some cases, the body 200 may comprise a rounded and / or curved surface and / or edge. In some cases, the system 100 may comprise one or more system subcomponents that may rotate and / or translate the body 200, as shown in FIGS. 3A-3B. In some cases, the system may comprise one or more system subcomponents that may weigh and / or actuate the spray device 126, as shown in FIGS. 5A-5E.

[0025] In some cases, the system 100, as shown in FIGS. 1A-1C, may comprise a system enclosure 108 that may at least partially house, cover, and / or contain the one or more system subcomponents, described elsewhere herein. In some cases, the system 100 may comprise an enclosure cover 102 configured to close and / or seal an inner environment within the system enclosure from an environment external to the system enclosure 108. The enclosure cover 102 may prevent contamination (e.g., foreign aerosol particles) from entering into the system during spray device analysis and / or testing that may otherwise cause errors in dose collection and / orweighing of the spray device. In some cases, the enclosure cover 102, may comprise a handle interface 106 that may allow a user to open and / or temporarily remove the enclosure cover 102 to interact with one or more system subcomponents and / or to load and / or remove a spray device and / or to configure the one or more apparatuses mounted to the one or more mounting interfaces 113 of the body 200 prior to, during, and / or after analysis and testing. In some cases, the system 100 may comprise one or more fans 110 fluidically coupled to an interior region of the system enclosure 108 and / or an exterior region of the system enclosure to evacuate and / or to circulate air through the system to remove contaminant particles to reduce error in measured weight and / or collected and / or obtained dose(s) of the spray device. In some cases, the one or more fans 110 may be coupled to one or more filters, where the one or more filters may filter one or more particles (e.g., contaminant particles and / or leaked spray particles of the spray device) as the fluid environment (e.g., air within the enclosure) is circulated and / or agitated. In some cases, the system may comprise a light source (e.g. LED) 132 located on an interior of the system enclosure 108 to illuminate the inside of the system enclosure 108, or components thereof (e.g., for ease of loading / unloading the system).

[0026] In some cases, the system 100 may comprise a body 200 (e.g., an apparatus mounting body), as seen in FIGS. 2A-2E comprising one or more mounting interfaces 113 disposed along a curved surface or curved edge of the body, where one or more collection vessels 116, one or more waste vessels 118, and / or one or more cleaning apparatuses, may couple to the one or more mounting interfaces 113, and where the one or more collection vessels 116 may comprise an opening shaped and sized for receiving a tip 130 of the spray device 126. In some cases, the one or more mounting interfaces 113 may comprise at least about 12 mounting interfaces or at least about 20 mounting interfaces. In some cases, the one or more collection vessels 116 may comprise an adapter 202 that may seal with the tip 130 of the spray device 126 when the spray device is fluidically coupled to a collection vessel of the one or more collection vessels 116. In some cases, the adapter 202 may be removably coupled to the one or more collection vessels 116. In some cases, the adapter 202 may prevent the emitted spray dose of the spray device from leaking out of the collection vessel once the collection vessel has obtained and / or received the emitted spray dose. In some cases, the adapter 202 of the one or more collection vessels 116 may be sized and / or shaped to receive one or more sizes and / or shapes of a tip(s) 130 of a spray device 126. In some cases, the body may comprise a circular and / or curved structure. In some embodiments, the body may comprise a dome 114, where one or more systems sub-components, described elsewhere herein may be housed and / or at least partially covered. In some cases, the dome 114 may enable a compact system form factor that may be used on a lab bench. In some cases, the one or more mounting interfaces 113 may couple to one or more collection vessels116, one or more cleaning apparatuses, one or more waste vessels 118, or any combination thereof. In some cases, the one or more cleaning apparatuses may comprise a dabber comprising one or more surfaces configured to clean a tip 130 of the spray device 126. In some cases, the one or more waste vessels 118 may comprise an insert, where the insert may prevent an emitted spray dose of the spray device provided to the one or more waste vessels 118 from leaking out of the one or more waste vessels. In some cases, the insert may be removably coupled to the one or more waste vessels 118. In some instances, the one or more collection vessels 116, one or more cleaning apparatuses, one or more waste vessels 118, or any combination thereof, may couple to a mounting receptacle 112, where the mounting receptacle 112 removably couples to the one or more mounting interfaces 113. In some cases, the mounting receptacle 112 may comprise a basket. In some cases, the one or more collection vessels 116, one or more cleaning apparatuses, one or more waste vessels 118, or any combination thereof, may be slidably coupled to a mounting receptacle 112 to allow for translation of the one or more collection vessels 116, one or more cleaning apparatuses, one or more waste vessels 118, or any combination thereof. In some cases, the one or more collection vessels 116, one or more cleaning apparatuses, one or more waste vessels 118, or any combination thereof, may comprise a transition fit between the one or more collection vessels 116, one or more cleaning apparatuses, one or more waste vessels 118, or any combination thereof, and the mounting receptacle 112. In some cases, a mounting receptacle coupler 214 may be coupled to the one or more mounting interfaces 113. In some cases, one or more mounting receptacles 112 may be coupled to the body 200 through one or more fastening features 216 of the mounting receptacle coupler 214.

[0027] In some cases, the mounting receptacle 112 may comprise a body 218, as shown in FIGS. 2D-2E, that may provide a flag and / or extended body when one or more collection vessels 116, one or more cleaning apparatuses, one or more waste vessels 118, or any combination thereof, couple to the mounting receptacle, as shown in FIG. 2E. In some cases, the mounting receptacle 112 may comprise a body and / or flag 218, that may transition from a first state shown in FIG. 2D, to a second state shown in FIG. 2E, where the flag and / or body is in an extended and / or deployed state 218. In some case, the system may comprise one or more sensors configured to detect and / or determine whether the flag and / or body is in the first state and / or in the second state. In some cases, the one or more sensors may be electrically coupled to one or more processors of the system, described elsewhere herein, that may receive information of an apparatus (e.g., one or more collection vessels, one or more waste vessels, and / or one or more cleaning apparatuses) coupled to the one or more mounting interfaces 113 and / or the one or more mounting receptacles 112. The information may be saved to a memory location of the system, later utilized for other analysis processing methods, and / or stored in memory in combination withmeasured data acquired and / or obtained (e.g., weight values of the spray device) through the spray device testing process.

[0028] In some cases, a position of the one or more collection vessels 116, one or more cleaning apparatuses, one or more waste vessels 118, or any combination thereof, coupled to the body 200 may be set by a user of the system e.g., a user configuring and setting up the body for testing beginning-of-life, middle-of-life, and / or end-of-life, emitted doses of a spray device. In some cases, the arrangement may comprise at least about 10 collection vessels, at least about 12 collection vessels, or at least about 13 collection vessels coupled to the body 200. In some cases, the position of the one or more collection vessels 116, one or more cleaning apparatuses, one or more waste vessels 118, or any combination thereof, may be detected, determined, and / or indexed by a user and / or software of the system, described elsewhere herein. The position of the one or more collection vessels 116, one or more cleaning apparatuses, one or more waste vessels 118, may be determined and / or detected by the one or more sensors detecting the second state of the body and / or flag 218, described elsewhere herein. The indexed position may be used in combination with one or more operating instructions of the software, described elsewhere herein, to precisely record the classification and / or characterization of the emitted spray (e.g., a dose emitted from the spray device at the beginning-of-life, middle-of-life, and / or end-of-life of the spray device) received in the corresponding indexed position for further processing and report generating. In some cases, a first plurality of collection vessels of the one or more collection vessels 116 may be configured to collect, receive, and / or obtain one or more emitted doses of the spray device at a beginning-of-life of the spray device. In some instances, a second plurality of collection vessels of the one or more collection vessels 116 may be configured to collect, receive, and / or obtain one or more emitted doses of the spray device at a middle-of-life of the spray device. In some cases, a third plurality of collection vessels of the one or more collection vessels 116 may be configured to collect, receive, and / or obtain one or more emitted doses of the spray device at an end-of-life of the spray device.

[0029] In some cases, the body 200 may comprise a body coupling interface 204, as shown in FIG. 2B, that may couple to one or more coupling features 304 of the shaft coupling interface 302, as shown in FIGS. 3A-3B. In some cases, the shaft 310 may rotate and / or translate the body 200 to couple one or more apparatuses (e.g., one or more collection vessels, one or more waste vessels, and / or one or more cleaning apparatuses) mounted to the one or more mounting interfaces 113 with a tip 130 of the spray device 126. In some cases, rotation and / or translation of the body 200 may be provided by one or more motors (316, 318) coupled to one or more mechanical components to transfer rotational torque and / or rotational motion of the one or more motors (316, 318) to rotational motion and / or translation of the shaft 310 and body 200. In somecases, the one or more motors (316, 318) may comprise stepper motors. In some cases, the translation of the shaft 310 may occur along an axis perpendicular to a surface of the body 200. In some cases, the shaft 310 may be coupled to a shaft translational coupler 324 that couples rotational torque and / or rotational motion of a first pulley gear 312 to the shaft 310 while the shaft 310 may translate along an axis perpendicular to a surface of the first pulley gear 312 and / or perpendicular to a surface of the body 200. In some cases, the shaft 310 may comprise a spline shaft. In some cases, the shaft translational coupler 324 may be coupled to the first pulley gear 312 through one or more fasteners 344. In some cases, a rotational torque and / or rotational motion of a first motor 316 may be transferred and / or translated from the first motor 316 to the shaft 310 through a first motor pulley gear 308 coupled to the shaft of the first motor 316 and a first belt 314 where the first belt 314 is coupled to the first pulley gear 312 and the first motor pulley gear 308, as shown in FIGS. 3A-3B. In some cases, the system comprises an adapter 346. The shaft 310 may comprise a nut that attaches to the adapter 346. The adapter 346 fits into the support bearing hubs 348 and allows rotation of the shaft 310 and the body 200. In some cases, the first pulley gear 312 may comprise a body that may be sensed by a sensor 306. In some cases, the sensor 306 may comprise an optical sensor, an electro-magnetic sensor, or a combination thereof. In some cases, the body of the first pulley gear 312 may interrupt and / or block an optical path of a first sensor 306 when the body is disposed within the optical path of the sensor thus registering a position of the first pulley gear 312. In some cases, a signal from the sensor 306 when the body interrupts and / or blocks an optical path of the sensor may be used to indicate a home and / or a reference position of the first pulley gear 312. In some cases, the home and / or reference position may be used in combination with the indexed positions of the one or more collection vessels, one or more cleaning apparatuses, one or more waste vessels, or any combination thereof to determine rotational and / or translational motion of the body 200.

[0030] In some cases, translation of the shaft 310 and / or the body 200 may comprise linear translation of the shaft along an axis perpendicular to a surface of the body 200. In some cases, the shaft 310 may comprise a round object (e.g., a ball) 322 disposed on a surface of the shaft 310, as shown in FIGS. 3A-3B. In some cases, the round object 322 may be disposed and / or coupled to an end surface of the shaft 310. In some cases, the round object 322 may be coupled to a path 320 of a curved body 206, where the curved body 206 is shown in FIGS. 4A-4B. In some instances, the shaft 310 may be translated along the axis perpendicular to the surface of the body 200 when the round object 322 traverses along the path 320 of the curved body 206. In some cases, the curved body 206 may comprise a cylindrical cam. In some cases, the path 320 of the curved body 206 may comprise a cam angle of up to about 30 degrees. In some cases, the shaft 310 may be translated along the axis perpendicular to the surface of the body 200 when thecurved body is rotated up to about 360 degrees along a central axis 402 of the curved body 206. In some cases, the path 320 of the curved body 206 may comprise a positive (i.e., upward) sloping path and / or a negative (i.e., downward) sloping path. In some cases, a downward sloping path may be adjacent and / or followed with an upward sloping path as the path spans across an edge or curved surface of the curved body 206. In some cases, the path 320 may be a repeating path with an upward sloping path adjacent to a downward sloping path. In some cases, the curved body 206 may be coupled to a second pulley gear 208 that transfers and / or translates rotational torque and / or rotational motion of a second motor 318 to rotate the curved body 206. In some instances, the curved body 206 may comprise a structure of a second pulley gear 208 disposed along an edge and / or curved surface of the curved body 206. In some cases, the curved body 206 may be disposed concentric with the second pulley gear 208. In some instances, the shaft of the second motor 318 may be coupled to a second motor pulley gear 210. The second motor pulley gear 210 may transfer and / or translate the rotational torque and / or the rotational motion of the second motor shaft to the second pulley gear 208 through a second belt 212 that is coupled to the second pulley gear 208 and the second motor pulley gear 210. In some cases, ball bearing interfaces 404 allow for the curved body 206 to rotate.

[0031] In some cases, the second pulley gear 208 may comprise a body that may be sensed by a second sensor. In some cases, the second sensor may comprise an optical sensor, an electromagnetic sensor, or a combination thereof. In some cases, the body of the second pulley gear 208 may interrupt and / or block an optical path of the second sensor when the body is disposed within the optical path of the second sensor thus registering a position of the second pulley gear 208. In some cases, a signal from the second sensor when the body interrupts and / or blocks an optical path of the second sensor may be used to indicate a home and / or a reference position of the second pulley gear 208. In some cases, the home and / or reference position may be used in combination with the indexed positions of the one or more collection vessels, one or more cleaning apparatuses, one or more waste vessels, or any combination thereof to determine rotational and / or translational motion of the body 200.

[0032] In some cases, the first motor 316 may be coupled and / or fastened to a base 334 of the system with a curved bracket 326. In some cases, the curved bracket 326 may be coupled and / or fastened to the base 334 of the system through one or more fasteners 342. In some instances, the first motor 316 may be coupled to the curved bracket 326 by a curved bracket mounting body 328. In some cases, the first motor 316 may be coupled to the curved bracket mounting body 328 by one or more fasteners 330 fastening a first motor mounting plate 332 to the curved bracket mounting body 328 and the first motor 316.

[0033] In some cases, the second motor 318 may be coupled and / or fastened to the base 334 of the system with a second motor mounting bracket 340. In some instances, the second motor 318 may be coupled to the second motor mounting bracket 340 through one or more fasteners 336 coupling a second motor mounting plate 336 to the second motor mounting bracket 340. In some cases, the one or more fasteners 320 may couple the second motor 318, second motor mounting bracket 340, second motor mounting plate 338, or any combination thereof, through one or more threaded posts and / or offset mounting features 343 coupled to the base 334 of the system.

[0034] In some instances, the curved body 206 may be coupled to the base 334 of the system through a bearing fastener 400, as seen in FIGS. 4A-4B. In some cases, the bearing fastener 400 may fasten a position of the curved body 206 to the base 334 while allowing the curved body to rotate about a central axis 402 of the curved body 206.

[0035] In some cases, the system may comprise a weighing module (502, 504, 506, 508, 124, 510), and / or a spray device actuator (120, 520, 522, 523, 524, 526) as shown in FIGS. 5A-5E. In some instances, the weighing module may weigh a spray device 126 coupled to a collar 128 before and / or after the spray device 126 is actuated (i.e., causing the spray device to emit a spray dose) to measure a metered spray dose weight, described elsewhere herein. In some cases, the system 100 may comprise one or more leveling features 104 that may isolate and protect the system 100 components, e.g., the weighing module to stabilize the weight measurements of the spray device 126. In some cases, the one or more leveling features 104 may be adjustable. In some cases, the one or more leveling features 104 may comprise a dampener to reduce vibrations from transferring to the system 100 occurring on a surface where the system 100 is placed (e.g., a lab bench surface).

[0036] In some cases, the system for weighing a spray device 500 may comprise: (a) a collar 128 coupled to the spray device 126; (b) a lift actuator (505, 514, 512) to translate the collar 128 along an axis orthogonal to a surface of the collar 128; and (c) a weighing module (502, 504, 506, 508, 124, 510), where a surface of the weighing module 506 is coupled to a body 124, where a mass 502 is cantilevered on the body 124, and where the weighing module weighs the spray device 126 when the collar 128 contacts the body 124. In some cases, the collar may be translated along an axis perpendicular to the surface of the body 124 by the lift actuator (505, 514, 512). In some instances, the collar 128 may comprise a collet. In some cases, the collar 128 may at least partially surround one or more surfaces of the spray device 126. In some instances, the collar 128 may at least partially surround a tip 130 of the spray device 126. In some cases, the collar 128 may couple to the spray device 126 based on an interference fit between one or more curved features of the collar 128 and the shape and size of the tip 130 of the spray device 126.

[0037] In some cases, the lift actuator may comprise one or more bodies 514 configured to contact one or more surfaces of the collar 128 to translate the collar towards and / or away from the weighing module body 124. In some cases, the one or more bodies of the lift actuator 514 may comprise one or more lift actuator body interfaces 512, where one or more surfaces of the lift actuator body interface 512 contact one or more surfaces of the collar 128. In some cases, the lift actuator may comprise a solenoid 505 coupled to the one or more bodies of the lift actuator 514 and the one or more lift actuator body interfaces 512. In some cases, the solenoid 505 may be actuated to translate the one or more bodies of the lift actuator 514 and the one or more lift actuator body interfaces 512 coupled to a surface of the collar 128 towards and / or away from the one or more mounting interfaces 510 of the weighing module. In some cases, the lift actuator may translate the collar 128 coupled to the spray device such that one or more surfaces of the collar 128 are in contact with a surface of plate 518 in a ready to actuate position. In some cases, the solenoid 505 may comprise a dampened solenoid.

[0038] In some cases, the one or more bodies of the lift actuator 514 and / or the one or more lift actuator body interfaces 512 may translate and / or move the collar 128 coupled to the spray device 126 from a position where the spray device 126 is actuated and / or ready for actuation to a position where the collar 128 and the spray device 126 are weighed. In some cases, the one or more bodies of the lift actuator 514 and / or the one or more lift actuator body interfaces 512 may translate the collar 128 coupled to the spray device 126 towards one or more mounting interfaces 510 of the weighing module. In some cases, the one or more mounting interfaces 510 of the weighing module may contact one or more surfaces of the collar 128. In some cases, the one or more mounting interfaces 510 of the weighing module may comprise one or more features protruding from a surface of the weighing module body 124. In some cases, the weighing module body 124 may be coupled to a mass 502, a surface 506 of the weighing module interface 504, one or more mounting interfaces 510 of the weighing module body 124, or any combination thereof. In some cases, the weighing module body 124 may be coupled to the mass 502 by one or more fasteners 530, as shown in FIG. 5C. In some instances, the weighing module body 124 may be coupled to the surface 506 of the weighing module interface 504 by one or more fasteners 528. In some cases, the weighing module interface 504 may be coupled to one or more mechanical and / or one or more electrical components of the weighing module provided at least partially covered by a weighing module housing 508. In some cases, the weighing module (502, 504, 506, 508, 124, 510) may be coupled and / or fastened to a base of the system by a weighing module mounting bracket 509. In some cases, the weighing module housing 508 may comprise a mounting flange 511 that may be coupled to the weighing module mounting bracket 509 by oneor more fasteners 513, as shown in FIG. 5D. The weighing module mounting bracket 509 may be mounted to the base by one or more fasteners 513.

[0039] In some instances, the mass 502 may be disposed cantilevered on the weighing module body 124. In some cases, the mass 502 may be disposed at a first end of the weighing module body 124 where the one or more mounting interfaces 510 of the weighing module are disposed at a second end of the weighing module body 124. In some cases, the mass 502 may increase accuracy, sensitivity, specificity, or any combination thereof of the weighing module (502, 504, 506, 508, 124, 510) by at least about 5%, at least about 10%, at least about 15%, at least about 20%, at least about 25%, or at least about 30% compared to the weighing module without the mass 502. In some cases, the mass 502 may increase accuracy, sensitivity, specificity, or any combination thereof of the weighing module (502, 504, 506, 508, 124, 510) by up to about 5%, up to about 10%, up to about 15%, up to about 20%, up to about 25%, or up to about 30% compared to the weighing module without the mass 502. In some cases, when the spray device 126 and / or collar 128 are weighed by the weighing module, the spray device 126 and / or collar 128 may not be in contact with the actuator (120, 520, 522, 523, 524, 526). The mass 502 may act as a counterweight to offset the cantilevered load on the weighing module body 124 created by the weight of the collar 128 and the device on the other end of the weighing module body 124. In some embodiments, another collar (verification collar) may be used to hold specific reference masses (e.g., 5g, 10g, 100g, etc.) to verify the performance of the weighing module 124, including a zero condition. The verification process may comprise the following steps: 1) user inserts the verification collar in the same manner as the collar 128; 2) the lift actuator body interface 512 lowers the verification collar onto the weighing module 124; 3) the weighing module 124 is tared (e.g., its output is set to zero); 4) the first reference mass is added to the verification collar; 5) the system records the weight of reference mass; 6) the reference mass is removed from the verification collar; 7) steps 4-6 are repeated for the remaining reference masses; 7) results are compared against expectations and pass / fail is assessed / reported by the system. Steps 4-6 may be repeated n times (e.g., n=20) for the same reference mass to measure uncertainty / variability in measured weight of each reference mass.

[0040] In some cases, the actuator (120, 520, 522, 523, 524, 526) may actuate, press, and / or compress the spray device 126 to cause the spray device to emit a spray dose. In some cases, a surface of the actuator 120 may be brough into contact with a surface of the spray device 126 to compress, press, and / or translate a surface of the spray body 126 towards the collar 128 when one or more surfaces of the collar 218 are contact with the actuator plate 518 thereby emitting a spray dose of the spray device 126. In some cases, the actuator may translate along an axis perpendicular to a surface of the weighing module body 124 by rotating a threaded rod 520coupled to a motor, shown in FIG. 5E. When threaded rod 520 is rotated by a motor, the mated threaded receptacle 522 mounted to a bracket 526 may translate the surface of the actuator 120. In some cases, actuator may comprise a rack gear 524, coupled to a stationary bracket 516, and pinion gear 523 mounted to the actuator bracket 526, as shown in FIG. 5E. In some cases, the rack gear 524 and pinon gear 523 may provide smooth translational motion of the actuator surface 120. In some cases, when the spray device is actuated by the actuator (120, 520, 522, 523, 524, 526), the spray device may not be in contact with the weighing module (502, 504, 506, 508, 124, 510).

[0041] FIG. 9 shows a computer system 901 suitable for implementing the methods, described elsewhere herein. The computer system 901 may process various aspects of information and / or data generated by the systems and methods described elsewhere herein, such as, for example, one or more values of the spray device weight (e.g., obtained and / or measured at the spray device beginning-of-life, middle-of-life, and / or end-of-life), one or more detected and / or obtained indexed position of one or more apparatuses (e.g., one or more collection vessels, one or more waste vessels, and / or one or more cleaning apparatuses) mounted on the body, one or more detected positions and / or relative positions of the first pulley gear and / or the second pulley gear, one or more index positions of one or more collection vessels and the associated spray dose obtained and / or collected (e.g., at the beginning-of-life, middle-of-life, and / or end-of-life of the spray device), or any combination thereof. In some cases, the computer system may obtain, detect, and / or record the information and / or data in a memory location that may be further exported and / or processed by a user before, during, and / or after testing and / or analyzing a spray device.

[0042] In some cases, the computer system 901 may be electrically coupled and / or in electrical communication with a first motor 316 and / or a second motor 318, described elsewhere herein, to provide one or more signals to rotate the first motor 316 and / or the second motor 318 thereby rotating and / or translating the shaft 310 and body 200. In some instances, the computer system 901 may be electrically coupled to the first sensor 306 and / or the second sensor, described elsewhere herein, to detect and / or determine a rotational position (e.g., a home position and / or a relative rotational position) of the first pulley gear 312 and / or the second pulley gear 208. In some instances, the computer system 901 may be electrically coupled and / or in electrical communication with one or more sensors that detect and / or determine a transition of one or more bodies and / or flags 218 of one or more mounting receptacles 112, described elsewhere herein, from a first state to a second state. In some instances, the computer system 901 may be electrically coupled and / or in electrical communication with a motor coupled to threaded rod, where the computer system may provide one or more electrical signals to control translation ofthe lift actuator (512, 514, 520, 522, 523, 524, 526) to raise and / or lower the spray device 126. In some cases, the computer system 901 may be electrically coupled and / or in electrical communication with the weighing module (508, 504) to receive and / or obtain one or more values of the spray device weight prior to and / or after actuating the spray device. In some cases, the computer system 901 may be electrically coupled and / or in electrical communication with the spray device actuator (120, 520, 522, 523, 524, 526) to actuate the spray device to emit one or more spray doses.

[0043] The computer system 901 may be an electronic device. In some cases, the computer system 901 may comprise a laptop computer, personal computer, integrated computing device (e.g., housed within the enclosure 108 of the system (described elsewhere herein), or any combination thereof. In some cases, the computer system 901 may comprise a computer system external to the system 100. In some cases, the computer system 901 may be a mobile electronic device in electrical communication with the system 100 through a cable and / or over the internet and / or an intranet. The computer system 901 may comprise one or more central processing unit(s) (CPU, also “processor” and “computer processor” herein) 905, which may be a single core and / or a multi core processor, or a plurality of processor for parallel processing. The computer system 901 may further comprise memory and / or memory locations 904 (e.g., randomaccess memory, read-only memory, and / or flash memory), electronic storage unit 906 (e.g., hard disk), communications interface 908 (e.g., network adapter) for communicating with one or more other devices, peripheral devices 907, such as cache, other memory, data storage and / or electronic display adapters, or any combination thereof. The memory 904, storage unit 906, interface 908, and peripheral devices 907 may be in communication with the CPU 905 through a communication bus (e.g., solid lines), such as a motherboard. The storage unit 906 may be a data storage unit (or a data repository) for storing data e.g., the metered dose weight of the spray device and / or the indexed position of the one or more apparatuses mounted to the one or more mounting interfaces of the body 200. The computer system 901 may be operatively coupled to a computer network (“network”) 900 with the aid of the communication interface 908. The network 900 may be the Internet, an internet and / or extranet, or an intranet and / or extranet that is in communication with the Internet. The network 900 may, in some case, be a telecommunication and / or data network. The network 900 may include one or more computer servers, which may enable distributed computing, such as cloud computing. The network 900, in some cases with the aid of the computer system 901, may implement a peer-to-peer network, which may enable devices coupled to the computer system 901 to behave as a client or a server.

[0044] The CPU 905 may execute a sequence of machine -readable instructions, which may be embodied in a program or software. The instructions may be directed to the CPU 905, which maysubsequently program or otherwise configured the CPU 905 to implement methods of the present disclosure. Examples of operations performed by the CPU 905 may include fetch, decode, execute, and writeback.

[0045] The CPU 905 may be part of a circuit, such as an integrated circuit. One or more other components of the system 901 may be included in the circuit. In some cases, the circuit may be an application specific integrated circuit (ASIC).

[0046] The storage unit 906 may store files, such as drivers, libraries, and saved programs. The storage unit 906 may store data collected during the spray device testing process, described elsewhere herein (e.g., the metered dose weight of the spray device and indexed position of the one or more apparatuses coupled to the one or more mounting interfaces of the body). The storage unit 906 may also store one or more values of the spray device weight (e.g., obtained and / or measured at the spray device beginning-of-life, middle-of-life, and / or end-of-life), one or more detected and / or obtained indexed position of one or more apparatuses (e.g., one or more collection vessels, one or more waste vessels, and / or one or more cleaning apparatuses) mounted on the body, one or more detected positions and / or relative positions of the first pulley gear and / or the second pulley gear, one or more index positions of one or more collection vessels and the associated spray dose obtained and / or collected (e.g., at the beginning-of-life, middle-of-life, and / or end-of-life of the spray device), or any combination thereof. The computer system 901, in some cases may include one or more additional data storage units that are external to the computer system 901, such as located on a remote server that is in communication with the computer system 901 through an intranet or the internet 900.

[0047] Methods, as described herein, may be implemented by way of machine (e.g., computer processor) executable code stored on an electronic storage location of the computer device 901, such as, for example, on the memory 904 or electronic storage unit 906. The machine executable or machine-readable code may be provided in the form of software. During use, the code may be executed by the one or more processor(s) 905. In some instances, the code may be retrieved from the storage unit 906 and stored on the memory 904 for ready access by the one or more processor(s) 905. In some instances, the electronic storage unit 906 may be precluded, and machine-executable instructions are stored on memory 904.

[0048] The code may be pre-compiled and configured for use with a machine having a processor adapted to execute the code or may be compiled during runtime. The code may be supplied in a programming language that may be selected to enable the code to be executed in a pre-complied or as-compiled fashion.

[0049] Aspects of the systems and methods provided herein, such as the computer system 901, may be embodied in programming. Various aspects of the technology may be thought of a“product” or “articles of manufacture” typically in the form of a machine (or processor) executable code and / or associated data that is carried on or embodied in a type of machine readable medium. Machine-executable code may be stored on an electronic storage unit, such memory (e.g., read-only memory, random-access memory, flash memory) or a hard disk. “Storage” type media may include any or all of the tangible memory of a computer, processor the like, or associated modules thereof, such as various semiconductor memories, tape drives, disk drives and the like, which may provide non-transitory storage at any time for the software programming. All or portions of the software may at times be communicated through the Internet or various other telecommunication networks. Such communications, for example, may enable loading of the software from one computer or processor into another, for example, from a management server or host computer into the computer platform of an application server. Thus, another type of media that may bear the software elements includes optical, electrical, and electromagnetic waves, such as used across physical interfaces between local devices, through wired and optical landline networks and over various air-links. The physical elements that carry such waves, such as wired or wireless links, optical links, or the like, also may be considered as media bearing the software. As used herein, unless restricted to non-transitory, tangible “storage’ media, term such as computer or machine “readable medium” refer to any medium that participates in providing instructions to a processor for execution.

[0050] Hence, a machine-readable medium, such as computer-executable code, may take many forms, including but not limited to, a tangible storage medium, a carrier wave medium or physical transmission medium. Non-volatile storage media may include, for example, optical or magnetic disks, such as any of the storage devices in any computer(s) or the like, such as may be used to implement the databases, etc. Volatile storage media may include dynamic memory, such as main memory of such a computer platform. Tangible transmission media may include coaxial cables; copper wire and fiber optics, including the wires that comprise a bus within a computer device. Carrier-wave transmission media may take the form of electric or electromagnetic signals, or acoustic or light waves such as those generated during radio frequency (RF) and infrared (IR) data communications. Common forms of computer-readable media may therefor include for example: a floppy disk, a flexible disk, hard disk, magnetic tape, any other magnetic medium, a CD-ROM, DVD or DVD-ROM, any other optical medium, punch cards paper tape, any other physical storage medium with pattern of holes, a RAM, a ROM, a PROM and EPROM, a FLASH-EPROM, any other memory chip or cartridge, a carrier wave transporting data or instructions, cables or links transporting such a carrier wave, or any other medium from which a computer may read programming code and / or data. Many of these forms of computer readablemedia may be involved in carrying one or more sequences of one more instruction to a processor for execution.

[0051] The computer system may include or be in communication with an electronic display 902 that comprises a user interface (UI) 903 for showing a user the progress in the spray device testing protocol, the measure metered dose weights of the spray device, indexed configuration of the one or more apparatuses mounted to the one or more mounting interfaces of the body, rotational position of the first and / or second pulley gear, or a combination thereof. Examples of UI's include, without limitation, a graphical user interface (GUI) and web-based user interface.

[0052] Methods and systems of the present disclosure can be implemented by way of one or more algorithms and with instructions provided with one or more processors as disclosed herein. An algorithm can be implemented by way of software upon execution by the central processing unit 905.

[0053] In some aspects, the disclosure provides a system, as described elsewhere herein, for collecting an emitted dose of a spray device, comprising: one or more processors, and memory storing one or more programs for execution by the one or more processors, the one or more programs comprising instructions to: (i) rotate a body comprising one or more mounting interfaces disposed along a curved surface or edge of the body, where one or more collection vessels are coupled to the one or more mounting interfaces; and (ii) collect the emitted dose of the spray device in a collection vessel of the one or more collection vessels.

[0054] In some aspects, the disclosure provides a system, as described elsewhere herein, for weighing a spray device, comprising: one or more processors, and memory storing one or more programs for execution by the one or more processors, the one or more programs comprising instructions to: (i) contact a collar coupled to the spray device to a surface of a body coupled to a weighing module, where a mass is cantilevered on the body; and (ii) weigh the spray device with a weighing module.Methods

[0055] Aspects of the disclosure describe a method 600 to rotate and / or translate one or more collection vessels, one or more waste vessels, and / or one or more cleaning apparatuses to fluidically couple and / or contact a tip of a spray device, described elsewhere herein, as shown in FIG. 6. In some cases, the method 600 may comprise: (a) rotating a body comprising one or more mounting interfaces disposed along a curved surface and / or edge of the body, where one or more collection vessels are coupled to the one or more mounting interfaces 602; and (b) collecting the emitted dose of the spray device in a collection vessel of the one or more collection vessels 604. In some cases, one or more cleaning apparatus may be coupled to the one or moremounting interfaces of the body. In some instances, the one or more cleaning apparatuses may comprise a dabber. In some cases, one or more waste vessels may be coupled to the one or more mounting interfaces. In some cases, the one or more waste vessels may comprise an insert configured to seal between the one or more waste vessels and the spray device when the spray device is emitting a waste dose into the waste vessel of the one or more waste vessels. In some cases, the insert of the one or more waste vessels may be removably coupled to the one or more waste vessels. In some cases, the one or more mounting interfaces may comprise a body, where the body may transition from a first state to a second state when the one or more collection vessels, the one or more waste vessels, the one or more cleaning apparatuses, or any combination thereof, couple to the one or more mounting interfaces. In some instances, the first state may comprise a retracted state of the body, and where the second state comprises an extended state of the body. In some cases, one or more sensors may detect or determine the first state and / or the second state of the body. In some instances, the body may comprise a circular body. In some cases, the body may comprise a dome. In some cases, the body may be coupled to a motor, where the motor may rotate the body to align an input of the one or more collection vessels with an output of the spray device. In some cases, the one or more collection vessels may be indexed to receive one or more emitted doses of the spray device at a beginning, middle, or end-of-life stage of the spray device. In some instances, a first plurality of collection vessels of the one or more collection vessels may be configured to collect one or more emitted doses of the spray device at the beginning-of-life stage of the spray device. In some cases, a second plurality of collection vessels of the one or more collection vessels may be configured to collect one or more emitted doses of the spray device at the middle-of-life stage of the spray device. In some instances, a third plurality of collection vessels of the one or more collection vessels may be configured to collect one or more emitted doses of the spray device at the end-of-life stage of the spray device. In some instances, the one or more mounting interfaces may comprise a basket. In some cases, the one or more mounting interfaces may be removably coupled to the body. In some instances, the one or more collection vessels may comprise an input adaptor fluidically coupled to the one or more collection vessels, and where the input adaptor may form a seal with the spray device when the spray device emits a dose into the one or more collection vessels. In some cases, the one or more collection vessels may be coupled to the one or more mounting interfaces with a transition fit. In some instances, the one or more collection vessels may be slidably coupled to the one or more mounting interfaces. In some cases, the emitted dose of the spray device may be collected in the collection vessel of the one or more collection vessels when the collection vessel and the spray device are fluidically coupled. In some instances, the spray device may comprise a nasal and / or an oral spray device. In some cases, the body may be at least partially covered by anenclosure. In some instances, the enclosure may comprise a cover configured to seal an interior region of the enclosure from a region outside the enclosure. In some instances, the enclosure may comprise one or more fans fluidically coupled to the interior region of the enclosure and the region outside the enclosure. In some instances, one or more processors may be electrically coupled to the motor mechanically coupled to the body. In some cases, the body may be rotated by the one or more processors providing a signal to the motor to rotate the body to fluidically couple an indexed collection vessel of the one or more indexed collection vessels to the spray device. In some instances, the one or more mounting interfaces may comprise at least about 12 mounting interfaces or at least about 20 mounting interfaces.

[0056] In some cases, the method 700 may comprise a method to rotate and / or translate one or more collection vessels, one or more waste vessels, and / or one or more cleaning apparatuses, to fluidically couple to and / or seal to a tip of a spray device to receive, collect, and / or obtain one or more spray doses of the spray device, as shown in FIG. 7. In some cases, the method for collecting an emitted dose of the spray device 700 may comprise: (a) rotating a shaft coupled to a body, where the body comprises one or more mounting interfaces, where one or more collection vessels are coupled to the one or more mounting interfaces 702; (b) translating the shaft along an axis perpendicular to a surface of the body 704; and (c) collecting the emitted dose of the spray device when a collection vessel of the one or more collection vessels is fluidically coupled to the spray device 706. In some cases, the shaft may comprise a ball disposed at a surface of said shaft. In some instances, the shaft may be translated along said axis perpendicular to said surface of said body when said ball is translated along a curved path of a curved body. In some cases, the curved body may comprise a cylindrical cam. In some cases, the cylindrical cam may comprise a cam angle of up to about 30 degrees. In some instances, the cylindrical cam may be rotated up to about 360 degrees. In some instances, the path of the curved body may comprise a repeating path, described elsewhere herein. In some cases, the shaft may be rotated by a first pulley coupled to a first motor, and where the shaft is translated by a second pulley coupled to a second motor. In some instances, a rotational position of the first pulley may be determined by a first sensor. In some cases, a rotational position of the second pulley may be determined by a second sensor. In some instances, the first sensor, the second sensor, or a combination thereof, may comprise an optical sensor, an electro-magnetic sensor, or a combination thereof. In some cases, the first pulley may comprise a first pulley gear concentric with the shaft. In some cases, the shaft may comprise a spline shaft. In some instances, the second pulley may comprise a second pulley gear concentric with the curved body. In some cases, the first pulley gear may comprise a first body configured to interrupt an optical path of the first sensor to indicate a rotational position of the first pulley gear. In some instances, the second pulley gear may comprise a second bodyconfigured to interrupt an optical path of the second sensor to indicate a rotational position of the second pulley gear. In some cases, the first motor, the second motor, or a combination thereof, may comprise a stepper motor. In some cases, the one or more mounting interfaces may be disposed along a curved surface and / or edge of the body. In some cases, the method may further comprise one or more cleaning apparatuses coupled to the one or more mounting interfaces. In some instances, the one or more cleaning apparatuses may comprise a dabber. In some cases, the method may further comprise one or more waste vessels coupled to the one or more mounting interfaces. In some instances, the one or more waste vessels may comprise an insert, where the insert seals the one or more waste vessels to the spray device when the spray device is emitting a waste dose into the waste vessel. In some cases, the insert of the one or more waste vessels may be removably coupled to the waste vessel. In some instances, the one or more mounting interfaces may comprise a body, where the body may be configured to transition from a first state to a second state when the one or more collection vessels, the one or more waste vessels, the one or more cleaning apparatuses, or any combination thereof, couple to the one or more mounting interfaces. In some instances, the first state may comprise a retracted state of the body, and where the second state may comprise an extended state of the body. In some cases, one or more sensors may detect and / or determine the first state and / or the second state of the body. In some instances, the body comprising the one or more mounting interfaces, may comprise a circular body. In some cases, the body comprising the one or more mounting interfaces may comprise a dome. In some instances, the one or more collection vessels may be indexed to receive one or more emitted doses of the spray device at a beginning, middle, and / or end-of-life stage of the spray device. In some instances, a first plurality of collection vessels of the one or more collection vessels may collect one or more emitted doses of the spray device at the beginning-of-life stage of the spray device. In some cases, a second plurality of collection vessels of the one or more collection vessels may be configured to collect one or more emitted doses of the spray device at the middle- of-life stage of the spray device. In some instances, a third plurality of collection vessels of the one or more collection vessels may be configured to collect one or more emitted doses of the spray device at the end-of-life stage of the spray device. In some instances, the one or more mounting interfaces may comprise a basket. In some cases, the one or more mounting interfaces may be removably coupled to the body. In some instances, the one or more collection vessels may comprise an input adaptor fluidically coupled to the one or more collection vessels, where the input adaptor may form a seal with the spray device when the spray device emits the dose into the one or more collection vessels. In some cases, the one or more collection vessels may be coupled to the one or more mounting interfaces with a transition fit. In some instances, the one or more collection vessels may be slidably coupled to the one or more mounting interfaces. In someinstances, the spray device may comprise a nasal and / or oral spray device. In some cases, the body may be at least partially covered by an enclosure. In some instances, the enclosure may comprise a cover configured to seal an interior region of the enclosure from a region outside the enclosure. In some cases, the enclosure may comprise one or more fans fluidically coupled to the interior region of the enclosure and the region outside the enclosure. In some instances, one or more processors may be electrically coupled to the first motor and / or the second motor. In some instances, the body comprising the one or more mounting interfaces may be rotated by the one or more processors providing a first signal to the first motor to rotate the body. In some cases, the body may be translated by the one or more processors providing a second signal to the second motor to translate the body. In some instances, the body may be rotated and / or translated to fluidically couple an indexed collection vessel of the one or more indexed collection vessels to the spray device. In some cases, the one or more mounting interfaces may comprise at least about 12 mounting interfaces or at least about 20 mounting interfaces.

[0057] In some instances, the methods may comprise a method 800 to weigh a spray device before and / or after the spray device is actuated to measure a metered dose weight of the spray device, as shown in FIG. 8. In some cases, the method 800 for weighing the spray device may comprise: weighing the spray device thereby determining a weight of the spray device when a collar coupled to the spray device contacts a body coupled to the weighing module, where a mass is cantilevered on the body 802. In some cases, the method 800 may further comprise actuating the spray device with a spray device actuator to emit a dose into a collection vessel. In some instances, the spray device may not be in contact with the spray device actuator when the weighing module weighs the spray device. In some cases, the spray device may not be in contact with the weighing module when the spray device is actuated. In some instances, the body of the weighing module may comprise one or more mounting features configured to contact a surface of the collar. In some cases, the one or more mounting features may comprise one or more protrusions disposed on a surface of the body. In some instances, the method 800 may further comprise translating the collar coupled to the spray device with a lift actuator. In some cases, the lift actuator may comprise one or more bodies. In some cases, one or more surfaces of the one or more bodies of the lift actuator may be configured to couple to one or more surfaces of the collar. In some instances, the method 800 may further comprise leveling the weighing module with one or more leveling features. In some instances, the one or more leveling features may be adjustable. In some cases, the spray device may comprise a nasal and / or oral spray device. In some instances, the mass may be cantilevered on a first end of the body coupled to the weighing module opposite a second end of the body where the collar and / or the spray device contact the body. In some cases, the collar may comprise a collet. In some instances, the weighing module,the collar, the spray device, the lift actuator, or a combination thereof, is at least partially covered by an enclosure. In some instances, the enclosure may comprise a cover configured to seal an interior region of the enclosure from a region outside the enclosure. In some cases, the enclosure may comprise one or more fans fluidically coupled to the interior region of the enclosure and the region outside the enclosure.

[0058] While preferred embodiments of the present invention have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the invention. It should be understood that various alternatives to the embodiments of the invention described herein may be employed in practicing the invention. It is intended that the following claims define the scope of the invention and that methods and structures within the scope of these claims and their equivalents be covered thereby.

[0059] Although the above steps show each of the methods or sets of operations in accordance with embodiments described elsewhere herein, a person of ordinary skill in the art will recognize many variations based on the teaching described herein. The steps may be completed in a different order. Steps may be added or omitted. Some of the steps may comprise sub-steps. Many of the steps may be repeated as often as beneficial. One or more of the steps of each of the methods or sets of operations may be performed with circuitry as described herein, for example, one or more of the processor or logic circuitry such as programmable array logic for a field programmable gate array. The circuitry may be programmed to provide one or more of the steps of each of the methods or sets of operations, and the program may comprise program instructions stored on a computer readable memory or programmed steps of the logic circuitry such as the programmable array logic or the field programmable gate array, for example.EXAMPLESExample 1: Measuring a metered dose of a spray device

[0060] The systems and methods, described elsewhere herein, may be used to measure a metered dose of a spray device at the beginning-of-life, middle-of-life, and / or end-of-life of the spray device. A user opens the cover of the enclosure to expose the spray device interface of the system and subsequently loads a primed spray device coupled to a collar into the system. The user then configures the body comprising the one or more mounting interfaces with one or more collection vessels, one or more waste vessels, and / or one or more cleaning apparatuses, in-line with the spray device testing protocol. The system notes and / or records the indexed position of the one or more collection vessels, one or more waste vessels, and / or one or more cleaning apparatuseswhen they are loaded into the one or more mounting interfaces of the body. Once the body and the spray device are loaded into the system, the user then presses the action button of the system indicating that the testing protocol is to commence once the system cover is closed. The user then closes the cover of the enclosure and the spray device testing commences.

[0061] The system lowers the collar and spray device onto one or more mounting interfaces of the weighing body of the weighing module with a lift actuator and conducts a baseline weight measurement of the spray device. The system then raises the collar and spray device with the lift actuator such that a surface of the collar is in contact with the system plate and translates the actuator surface to contact a surface of the spray device. The system then rotates and / or translates the body with the one or more mounting interfaces coupled to the one or more collection vessels, one or more waste vessels, and / or one or more cleaning apparatuses (e.g., one or more apparatuses) to align a collection vessel of the one or more collection vessels to a tip of the spray device. The spray device then is actuated by the actuator providing a dose to a first collection vessel of the one or more collection vessels for a beginning-of-life dose of the spray device. The system then rotates and / or translates the body coupled to the one or more cleaning apparatuses such that a surface of the cleaning apparatus contacts the tip of the spraying device to clean any residue and / or excess spray from the tip of the spray device. The system then lowers the collar and spray device with the lift actuator such that the collar contacts one or more mounting interfaces of the weighing body of the weighing module to conduct a metered dose measurement for the first spray dose. The system then rotates and translates the body coupled to the one or more apparatuses to align and couple a second collection vessel of the one or more collection vessels with a tip of the spray device to repeat collecting a second spray dose as described above. According to the spray device testing protocol, one or more spray doses is collected and / or obtained by one or more waste vessels in between collecting one or more doses in one or more collection vessels.

[0062] A report of all of the beginning-of-life, middle-of-life, and / or end-of-life meter doses of the spray device is generated and displayed to the user once all testing is complete. The user then saves and / or exports the report.

Claims

CLAIMSWHAT IS CLAIMED IS:

1. A system for collecting an emitted dose of a spray device, comprising: a body comprising one or more mounting interfaces disposed along a curved surface or curved edge of said body, wherein one or more collection vessels are configured to couple to said one or more mounting interfaces, and wherein said one or more collection vessels comprise an opening shaped and sized for receiving a tip of said spray device.

2. The system of claim 1, further comprising a cleaning apparatus configured to couple to said one or more mounting interfaces.

3. The system of claim 2, wherein said cleaning apparatus comprises a dabber.

4. The system of claim 2 or 3, further comprising a waste vessel configured to couple to said one or more mounting interfaces.

5. The system of claim 4, wherein said waste vessel comprises an insert configured to seal between said waste vessel and said spray device when said spray device is emitting a waste dose into said waste vessel.

6. The system of claim 5, wherein said insert is removably coupled to said waste vessel.

7. The system of any one of claims 4-6, wherein said one or more mounting interfaces comprise a body, wherein said body is configured to transition from a first state to a second state when said one or more collection vessels, said waste vessel, said cleaning apparatus, or any combination thereof, couple to said one or more mounting interfaces.

8. The system of claim 7, wherein said first state comprises a retracted state of said body, and wherein said second state comprises an extended state of said body.

9. The system of claim 7 or 8, further comprising a sensor configured to detect said first state or said second state of said body.

10. The system of any one of claims 1-9, wherein said body comprises a circular body.

11. The system of any one of claims 1-10, wherein said body comprises a dome.

12. The system of any one of claims 1-11, further comprising a motor coupled to said body, wherein said motor is configured to rotate said body to align an input of said one or more collection vessels with an output of said spray device.

13. The system of any one of claims 1-12, wherein said one or more collection vessels are indexed to receive one or more emitted doses of said spray device at a beginning, middle, or end- of-life stage of said spray device.

14. The system of claim 13, wherein a first plurality of collection vessels of said one or more collection vessels are configured to collect one or more emitted doses of said spray device at said beginning-of-life stage of said spray device, wherein a second plurality of collection vessels of said one or more collection vessels are configured to collect one or more emitted doses of said spray device at said middle-of-life stage of said spray device, and wherein a third plurality of collection vessels of said one or more collection vessels are configured to collect one or more emitted doses of said spray device at said end-of-life stage of said spray device.

15. The system of any one of claims 1-14, wherein said one or more mounting interfaces comprise a basket.

16. The system of any one of claims 1-15, wherein said one or more mounting interfaces are removably coupled to said body.

17. The system of any one of claims 1-16, wherein said one or more collection vessels comprise an input adaptor fluidically coupled to said one or more collection vessels, and wherein said input adaptor is configured to form a seal with said spray device when said spray device emits said dose into said one or more collection vessels.

18. The system of any one of claims 1-17, wherein said one or more collection vessels are coupled to said one or more mounting interfaces with a transition fit.

19. The system of any one of claims 1-18, wherein said one or more collection vessels are slidably coupled to said one or more mounting interfaces.

20. The system of any one of claims 1-19, wherein said spray device comprises a nasal or oral spray device.

21. The system of any one of claims 1-20, wherein a position of said one or more collection vessels is indexed to receive said emitted dose of said spray device when said spray device is actuated.

22. The system of any one of claims 1-21, wherein said body is at least partially covered by an enclosure.

23. The system of claim 22, wherein said enclosure comprises a cover configured to seal an interior region of said enclosure from a region outside said enclosure.

24. The system of claim 23, wherein said enclosure comprises one or more fans fluidically coupled to said interior region of said enclosure and said region outside said enclosure.

25. The system of any one of claims 12-24, further comprising one or more processors electrically coupled to said motor.

26. The system of claim 25, wherein said one or more processors provide a signal to said motor to rotate said body to fluidically couple an indexed collection vessel of said one or more indexed collection vessels to said spray device.

27. The system of any one of claims 1-26, wherein said one or more mounting interfaces comprise at least about 12 mounting interfaces or at least about 20 mounting interfaces.

28. A method for collecting an emitted dose of a spray device, comprising:(a) rotating a body comprising one or more mounting interfaces disposed along a curved surface or edge of said body, wherein one or more collection vessels are coupled to said one or more mounting interfaces; and(b) collecting said emitted dose of said spray device in a collection vessel of said one or more collection vessels.

29. The method of claim 28, wherein a cleaning apparatus is coupled to said one or more mounting interfaces of said body.

30. The method of claim 29, wherein said cleaning apparatus comprises a dabber.

31. The method of claim 29 or 30, wherein a waste vessel is coupled to said one or more mounting interfaces.

32. The method of claim 31, wherein said waste vessel comprises an insert configured to seal between said waste vessel and said spray device when said spray device is emitting a waste dose into said waste vessel.

33. The method of claim 32, wherein said insert is removably coupled to said waste vessel.

34. The method of any one of claims 31-33, wherein said one or more mounting interfaces comprise a body, wherein said body is configured to transition from a first state to a second state when said one or more collection vessels, said waste vessel, said cleaning apparatus, or any combination thereof, couple to said one or more mounting interfaces.

35. The method of claim 34, wherein said first state comprises a retracted state of said body, and wherein said second state comprises an extended state of said body.

36. The method of claim 34 or 35, wherein a sensor detects or determines said first state or said second state of said body.

37. The method of any one of claims 28-36, wherein said body comprises a circular body.

38. The method of any one of claims 28-37, wherein said body comprises a dome.

39. The method of any one of claims 28-38, wherein said body is coupled to a motor, wherein said motor rotates said body to align an input of said one or more collection vessels with an output of said spray device.

40. The method of any one of claims 28-39, wherein said one or more collection vessels are indexed to receive one or more emitted doses of said spray device at a beginning, middle, or end- of-life stage of said spray device.

41. The method of claim 40, wherein a first plurality of collection vessels of said one or more collection vessels are configured to collect one or more emitted doses of said spray device at saidbeginning-of-life stage of said spray device, wherein a second plurality of collection vessels of said one or more collection vessels are configured to collect one or more emitted doses of said spray device at said middle-of-life stage of said spray device, and wherein a third plurality of collection vessels of said one or more collection vessels are configured to collect one or more emitted doses of said spray device at said end-of-life stage of said spray device.

42. The method of any one of claims 28-41, wherein said one or more mounting interfaces comprise a basket.

43. The method of any one of claims 28-42, wherein said one or more mounting interfaces are removably coupled to said body.

44. The method of any one of claims 28-43, wherein said one or more collection vessels comprise an input adaptor fluidically coupled to said one or more collection vessels, and wherein said input adaptor is configured to form a seal with said spray device when said spray device emits said dose into said one or more collection vessels.

45. The method of any one of claims 28-44, wherein said one or more collection vessels are coupled to said one or more mounting interfaces with a transition fit.

46. The method of any one of claims 28-45, wherein said one or more collection vessels are slidably coupled to said one or more mounting interfaces.

47. The method of any one of claims 28-46, wherein said emitted dose of said spray device is collected in said collection vessel when said collection vessel and said spray device are fluidically coupled.

48. The method of any one of claims 28-47, wherein said spray device comprises a nasal or oral spray device.

49. The method of any one of claims 28-48, wherein said body is at least partially covered by an enclosure.

50. The method of claim 49, wherein said enclosure comprises a cover configured to seal an interior region of said enclosure from a region outside said enclosure.

51. The method of claim 50, wherein said enclosure comprises one or more fans fluidically coupled to said interior region of said enclosure and said region outside said enclosure.

52. The method of any one of claims 39-51, wherein one or more processors are electrically coupled to said motor mechanically coupled to said body.

53. The method of claim 52, wherein said body is rotated by said one or more processors providing a signal to said motor to rotate said body to fluidically couple an indexed collection vessel of said one or more indexed collection vessels to said spray device.

54. The method of any one of claims 28-53, wherein said one or more mounting interfaces comprise at least about 12 mounting interfaces or at least about 20 mounting interfaces.

55. A system for collecting an emitted dose of a spray device, comprising:(a) a body comprising one or more mounting interfaces, wherein one or more collection vessels are coupled to said one or more mounting interfaces, and wherein said one or more collection vessels are configured to collect one or more emitted doses of a spray device;(b) a shaft coupled to said body;(c) a first motor coupled to said shaft configured to rotate said shaft thereby rotating said body; and(d) a second motor coupled to said shaft configured to translate said shaft along an axis perpendicular to a surface of said body thereby translating said body along said axis perpendicular to said surface of said body.

56. The system of claim 55, wherein said shaft comprises a spline shaft.

57. The system of claim 55 or 56, wherein said shaft comprises a ball disposed at a surface of said shaft.

58. The system of claim 57, wherein said shaft is translated along said axis perpendicular to said surface of said body when said ball is translated along a curved path of a curved body.

59. The system of claim 58, wherein said curved path comprises a repeating curved path along a curved edge or curved surface of the curved body.

60. The system of claim 58 or 59, wherein said curved body comprises a cylindrical cam.

61. The system of claim 60, wherein said cylindrical cam comprises a cam angle of up to about 30 degrees.

62. The system of claim 60 or 61, wherein said cylindrical cam is rotated up to about 360 degrees.

63. The system of any one of claims 58-62, wherein said first motor is coupled to a first pulley coupled to said shaft and wherein said second motor is coupled to a second pulley coupled to said curved body.

64. The system of claim 63, further comprising a first sensor configured to determine a rotational position of said first pulley, and a second sensor configured to determine a rotational position of said second pulley.

65. The system of claim 64, wherein said first sensor, said second sensor, or a combination thereof, comprise an optical sensor, an electro-magnetic sensor, or a combination thereof.

66. The system of any one of claims 63-65, wherein said first pulley comprises a first pulley gear concentric with said shaft, and wherein said second pulley comprises a second pulley gear concentric with said curved body.

67. The system of claim 66, wherein said first pulley gear comprises a first body configured to interrupt an optical path of said first sensor to indicate a rotational position of said first pulley gear, and wherein said second pulley gear comprises a second body configured to interrupt an optical path of said second sensor to indicate a rotational position of said second pulley gear.

68. The system of any one of claims 55-67, wherein said first motor, said second motor, or a combination thereof, comprise a stepper motor.

69. The system of any one of claims 55-68, wherein said one or more mounting interfaces are disposed along a curved surface or edge of said body.

70. The system of any one of claims 55-69, further comprising a cleaning apparatus configured to couple to said one or more mounting interfaces.

71. The system of claim 70, wherein said cleaning apparatus comprises a dabber.

72. The system of claim 70 or 71, further comprising a waste vessel configured to couple to said one or more mounting interfaces.

73. The system of claim 72, wherein said waste vessel comprises an insert configured to seal between said waste vessel and said spray device when said spray device is emitting a waste dose into said waste vessel.

74. The system of claim 73, wherein said insert is removably coupled to said waste vessel.

75. The system of any one of claims 72-74, wherein said one or more mounting interfaces comprise a body, wherein said body is configured to transition from a first state to a second state when said one or more collection vessels, said cleaning apparatus, said waste vessel, or any combination thereof, couple to said one or more mounting interfaces.

76. The system of claim 75, wherein said first state comprises a retracted state of said body, and wherein said second state comprises an extended state of said body.

77. The system of claim 75 or 76, further comprising a sensor configured to detect said first state or said second state of said body.

78. The system of any one of claims 55-77, wherein said body comprises a circular body.

79. The system of any one of claims 55-78, wherein said body comprises a dome.

80. The system of any one of claims 55-79, wherein said one or more collection vessels are indexed to receive one or more emitted doses of said spray device at a beginning, middle, or end- of-life stage of said spray device.

81. The system of claim 80, wherein a first plurality of collection vessels of said one or more collection vessels are configured to collect one or more emitted doses of said spray device at said beginning-of-life stage of said spray device, wherein a second plurality of collection vessels of said one or more collection vessels are configured to collect one or more emitted doses of said spray device at said middle-of-life stage of said spray device, and wherein a third plurality ofcollection vessels of said one or more collection vessels are configured to collect one or more emitted doses of said spray device at said end-of-life stage of said spray device82. The system of any one of claims 55-81, wherein said one or more mounting interfaces comprise a basket.

83. The system of any one of claims 55-82, wherein said one or more mounting interfaces are removably coupled to said body.

84. The system of any one of claims 55-83, wherein said one or more collection vessels comprise an input adaptor fluidically coupled to said one or more collection vessels, and wherein said input adaptor is configured to form a seal with said spray device when said spray device emits said dose into said one or more collection vessels.

85. The system of any one of claims 55-84, wherein said one or more collection vessels are coupled to said one or more mounting interfaces with a transition fit.

86. The system of any one of claims 55-85, wherein said one or more collection vessels are slidably coupled to said one or more mounting interfaces.

87. The system of any one of claims 55-86, wherein said spray device comprises a nasal or oral spray device.

88. The system of any one of claims 55-87, wherein said body is at least partially covered by an enclosure.

89. The system of claim 88, wherein said enclosure comprises a cover configured to seal an interior region of said enclosure from a region outside said enclosure.

90. The system of claim 89, wherein said enclosure comprises one or more fans fluidically coupled to said interior region of said enclosure and said region outside said enclosure.

91. The system of any one of claims 55-90, further comprising one or more processors electrically coupled to said first motor or said second motor.

92. The system of claim 91, wherein said one or more processors provide a first signal to said first motor to rotate said body and a second signal to said second motor to translate said body, and wherein said body is rotated and translated to fluidically couple an indexed collection vessel of said one or more indexed collection vessels to said spray device.

93. The system of any one of claims 55-92, wherein said one or more mounting interfaces comprise at least about 12 mounting interfaces or at least about 20 mounting interfaces.

94. A method for collecting an emitted dose of a spray device, comprising:(a) rotating a shaft coupled to a body, wherein said body comprises one or more mounting interfaces, wherein one or more collection vessels are coupled to said one or more mounting interfaces;(b) translating said shaft along an axis perpendicular to a surface of said body; and(c) collecting said emitted dose of said spray device when a collection vessel of said one or more collection vessels is fluidically coupled to said spray device.

95. The method of claim 94, wherein said shaft comprises a spline shaft.

96. The method of claim 94 or 95, wherein said shaft comprises a ball disposed at a surface of said shaft.

97. The method of claim 96, wherein said shaft is translated along said axis perpendicular to said surface of said body when said ball is translated along a curved path of a curved body.

98. The method of claim 97, wherein said curved path comprises a repeating curved path along a curved edge or curved surface of the curved body.

99. The method of claim 97 or 98, wherein said curved body comprises a cylindrical cam.

100. The method of claim 99, wherein cylindrical cam comprises a cam angle of up to about 30 degrees.

101. The method of claim 99 or 100, wherein said cylindrical cam is rotated up to about 360 degrees.

102. The method of any one of claims 94-101, wherein said shaft is rotated by a first pulley coupled to a first motor, and wherein said shaft is translated by a second pulley coupled to a second motor.

103. The method of claim 102, wherein a rotational position of said first pulley is determined by a first sensor, and wherein a rotational position of said second pulley is determined by a second sensor.

104. The method of claim 103, wherein said first sensor, said second sensor, or a combination thereof, comprise an optical sensor, an electro-magnetic sensor, or a combination thereof.

105. The method of any one of claims 102-104, wherein said first pulley comprises a first pulley gear concentric with said shaft, and wherein said second pulley comprises a second pulley gear concentric with said curved body.

106. The method of claim 105, wherein said first pulley gear comprises a first body configured to interrupt an optical path of said first sensor to indicate a rotational position of said first pulley gear, and wherein said second pulley gear comprises a second body configured to interrupt an optical path of said second sensor to indicate a rotational position of said second pulley gear.

107. The method of any one of claims 102-106, wherein said first motor, said second motor, or a combination thereof, comprise a stepper motor.

108. The method of any one of claims 94-107, wherein said one or more mounting interfaces are disposed along a curved surface or edge of said body.

109. The method of any one of claims 94-108, further comprising a cleaning apparatus coupled to said one or more mounting interfaces.

110. The method of claim 109, wherein said cleaning apparatus comprises a dabber.

111. The method of claim 109 or 110, further comprising a waste vessel coupled to said one or more mounting interfaces.

112. The method of claim 111, wherein said waste vessel comprises an insert configured to seal between said waste vessel and said spray device when said spray device is emitting a waste dose into said waste vessel.

113. The method of claim 112, wherein said insert is removably coupled to said waste vessel.

114. The method of any one of claims 111-113, wherein said one or more mounting interfaces comprise a body, wherein said body is configured to transition from a first state to a second state when said one or more collection vessels, said waste vessel, said cleaning apparatus, or any combination thereof, couple to said one or more mounting interfaces.

115. The method of claim 114, wherein said first state comprises a retracted state of said body, and wherein said second state comprises an extended state of said body.

116. The method of claim 114 or 115, wherein a sensor detects or determines said first state or said second state of said body.

117. The method of any one of claims 94-116, wherein said body comprises a circular body.

118. The method of any one of claims 94-117, wherein said body comprises a dome.

119. The method of any one of claims 94-118, wherein said one or more collection vessels are indexed to receive one or more emitted doses of said spray device at a beginning, middle, or end- of-life stage of said spray device.

120. The method of claim 119, wherein a first plurality of collection vessels of said one or more collection vessels are configured to collect one or more emitted doses of said spray device at said beginning-of-life stage of said spray device, wherein a second plurality of collection vessels of said one or more collection vessels are configured to collect one or more emitted doses of said spray device at said middle-of-life stage of said spray device, and wherein a third plurality of collection vessels of said one or more collection vessels are configured to collect one or more emitted doses of said spray device at said end-of-life stage of said spray device.

121. The method of any one of claims 94-120, wherein said one or more mounting interfaces comprise a basket.

122. The method of any one of claims 94-121, wherein said one or more mounting interfaces are removably coupled to said body.

123. The method of any one of claims 94-122, wherein said one or more collection vessels comprise an input adaptor fluidically coupled to said one or more collection vessels, and wherein said input adaptor is configured to form a seal with said spray device when said spray device emits said dose into said one or more collection vessels.

124. The method of any one of claims 94-123, wherein said one or more collection vessels are coupled to said one or more mounting interfaces with a transition fit.

125. The method of any one of claims 94-124, wherein said one or more collection vessels are slidably coupled to said one or more mounting interfaces.

126. The method of any one of claims 94-125, wherein said spray device comprises a nasal or oral spray device.

127. The method of any one of claims 94-126, wherein said body is at least partially covered by an enclosure.

128. The method of claim 127, wherein said enclosure comprises a cover configured to seal an interior region of said enclosure from a region outside said enclosure.

129. The method of claim 128, wherein said enclosure comprises one or more fans fluidically coupled to said interior region of said enclosure and said region outside said enclosure.

130. The method of any one of claims 102-129, wherein one or more processors are electrically coupled to said first motor or said second motor.

131. The method of claim 130, wherein said body is rotated by said one or more processors providing a first signal to said first motor to rotate said body, wherein said body is translated by said one or more processors providing a second signal to said second motor to translate said body, and wherein said body is rotated and translated to fluidically couple an indexed collection vessel of said one or more indexed collection vessels to said spray device.

132. The method of any one of claims 94-131, wherein said one or more mounting interfaces comprise at least about 12 mounting interfaces or at least about 20 mounting interfaces.

133. A system for weighing a spray device, comprising:(a) a collar coupled to said spray device;(b) a lift actuator configured to translate said collar along an axis orthogonal to a surface of said collar; and(c) a weighing module, wherein a surface of said weighing module is coupled to a body, wherein a mass is cantilevered on said body, and wherein said weighing module weighs said spray device when said collar contacts said body.

134. The system of claim 133, wherein said body comprises one or more mounting features configured to contact a surface of said collar.

135. The system of claim 134, wherein said one or more mounting features comprise one or more protrusions disposed on a surface of said body.

136. The system of any one of claims 133-135, further comprising a spray device actuator configured to actuate said spray device thereby emitting a dose of said spray device collected by a collection vessel.

137. The system of claim 136, wherein, said spray device is not in contact with said spray device actuator when said weighing module weighs said spray device.

138. The system of claim 136 or 137, wherein said spray device is not in contact with said weighing module when said spray device is actuated.

139. The system of any one of claims 133-138, further comprising one or more leveling features configured to level said weighing module.

140. The system of claim 139, wherein said one or more leveling features are adjustable.

141. The system of any one of claims 133-140, wherein said spray device comprises a nasal or oral spray device.

142. The system of any one of claims 133-141, wherein said lift actuator comprises one or more bodies, and wherein one or more surfaces of said one or more bodies is configured to couple to one or more surfaces of said collar.

143. The system of any one of claims 133-142, wherein said mass is cantilevered on a first end of said body opposite a second end of said body where said collar contacts said body.

144. The system of any one of claims 133-143, wherein said collar comprises a collet.

145. The system of any one of claims 133-144, wherein said body is at least partially covered by an enclosure.

146. The system of claim 145, wherein said enclosure comprises a cover configured to seal an interior region of said enclosure from a region outside said enclosure.

147. The system of claim 146, wherein said enclosure comprises one or more fans fluidically coupled to said interior region of said enclosure and said region outside said enclosure.

148. The system of any one of claims 133-147, wherein said weighing module, said lift actuator, said collar, said spray device, or any combination thereof, is at least partially covered by an enclosure.

149. The system of claim 148, wherein said enclosure comprises a cover configured to seal an interior region of said enclosure from a region outside said enclosure.

150. The system of claim 149, wherein said enclosure comprises one or more fans fluidically coupled to said interior region of said enclosure and said region outside said enclosure.

151. A method for weighing a spray device, comprising: weighing said spray device thereby determining a weight of said spray device when a collar coupled to said spray device contacts a body coupled to a weighing module, wherein a mass is cantilevered on said body.

152. The method of claim 151, further comprising actuating said spray device with a spray device actuator to emit a dose into a collection vessel.

153. The method of claim 152, wherein said spray device is not in contact with said spray device actuator when said weighing module weighs said spray device.

154. The method of claim 152 or 153, wherein said spray device is not in contact with said weighing module when said spray device is actuated.

155. The method of any one of claims 151-154, wherein said body comprises one or more mounting features configured to contact a surface of said collar.

156. The method of claim 155, wherein said one or more mounting features comprise one or more protrusions disposed on a surface of said body.

157. The method of claim 155 or 156, further comprising translating said collar coupled to said spray device with a lift actuator.

158. The method of claim 157, wherein said lift actuator comprises one or more bodies, and wherein one or more surfaces of said one or more bodies are configured to couple to one or more surfaces of said collar.

159. The method of any one of claims 151-158, further comprising leveling said weighing module with one or more leveling features.

160. The method of claim 159, wherein said one or more leveling features are adjustable.

161. The method of any one of claims 151-160, wherein said spray device comprises a nasal or oral spray device.

162. The method of any one of claims 151-161, wherein said mass is cantilevered on a first end of said body opposite a second end of said body where said collar contacts said body.

163. The method of any one of claims 151-162, wherein said collar comprises a collet.

164. The method of any one of claims 151-163, wherein said weighing module, said collar, said spray device, said lift actuator, or a combination thereof, is at least partially covered by an enclosure.

165. The method of claim 164, wherein said enclosure comprises a cover configured to seal an interior region of said enclosure from a region outside said enclosure.

166. The method of claim 165, wherein said enclosure comprises one or more fans fluidically coupled to said interior region of said enclosure and said region outside said enclosure.

167. A system for collecting an emitted dose of a spray device, comprising: one or more processors, and memory storing one or more programs for execution by said one or more processor, said one or more programs comprising instructions to:(i) rotate a body comprising one or more mounting interfaces disposed along a curved surface or edge of said body, wherein one or more collection vessels are coupled to said one or more mounting interfaces; and(ii) collect said emitted dose of said spray device in a collection vessel of said one or more collection vessels.

168. The system of claim 167, wherein a cleaning apparatus is coupled to said one or more mounting interfaces of said body.

169. The system of claim 168, wherein said cleaning apparatus comprises a dabber.

170. The system of claim 168 or 169, wherein a waste vessel is coupled to said one or more mounting interfaces.

171. The system of claim 170, wherein said waste vessel comprises an insert configured to seal between said waste vessel and said spray device when said spray device is emitting a waste dose into said waste vessel.

172. The system of claim 171, wherein said insert is removably coupled to said waste vessel.

173. The system of any one of claims 170-172, wherein said one or more mounting interfaces comprise a body, wherein said body is configured to transition from a first state to a second state when said one or more collection vessels, said waste vessel, said cleaning apparatus, or a combination thereof, couple to said one or more mounting interfaces.

174. The system of claim 173, wherein said first state comprises a retracted state of said body, and wherein said second state comprises an extended state of said body.

175. The system of claim 173 or 174, further comprising a sensor configured to detect said first state or said second state of said body.

176. The system of any one of claims 167-175, wherein said body comprises a circular body.

177. The system of any one of claims 167-176, wherein said body comprises a dome.

178. The system of any one of claims 167-177, wherein a motor is coupled to said body, wherein said motor is configured to rotate said body to align an input of said one or more collection vessels with an output of said spray device.

179. The system of any one of claims 167-178, wherein said one or more collection vessels are indexed to receive one or more emitted doses of said spray device at a beginning, middle, or end- of-life stage of said spray device.

180. The system of claim 179, wherein a first plurality of collection vessels of said one or more collection vessels are configured to collect one or more emitted doses of said spray device at said beginning-of-life stage of said spray device, wherein a second plurality of collection vessels of said one or more collection vessels are configured to collect one or more emitted doses of said spray device at said middle-of-life stage of said spray device, and wherein a third plurality of collection vessels of said one or more collection vessels are configured to collect one or more emitted doses of said spray device at said end-of-life stage of said spray device.

181. The system of any one of claims 167-180, wherein said one or more mounting interfaces comprise a basket.

182. The system of any one of claims 167-181, wherein said one or more mounting interfaces are removably coupled to said body.

183. The system of any one of claims 167-182, wherein said one or more collection vessels comprise an input adaptor fluidically coupled to said one or more collection vessels, and wherein said input adaptor is configured to form a seal with said spray device when said spray device emits said dose into said one or more collection vessels.

184. The system of any one of claims 167-183, wherein said one or more collection vessels are coupled to said one or more mounting interfaces with a transition fit.

185. The system of any one of claims 167-184, wherein said one or more collection vessels are slidably coupled to said one or more mounting interfaces.

186. The system of any one of claims 167-185, wherein said spray device comprises a nasal or oral spray device.

187. The system of any one of claims 167-186, wherein a position of said one or more collection vessels is indexed to receive said emitted dose of said spray device when said spray device is actuated.

188. The system of any one of claims 167-187, wherein said body is at least partially covered by an enclosure.

189. The system of claim 188, wherein said enclosure comprises a cover configured to seal an interior region of said enclosure from a region outside said enclosure.

190. The system of claim 189, wherein said enclosure comprises one or more fans fluidically coupled to said interior region of said enclosure and said region outside said enclosure.

191. The system of any one of claims 167-190, wherein said one or more processors are electrically coupled to a motor mechanically coupled to said body.

192. The system of claim 191, wherein said one or more processors provide a signal to said motor to rotate said body to fluidically couple an indexed collection vessel of said one or more indexed collection vessels to said spray device.

193. The system of any one of claims 167-192, wherein said one or more mounting interfaces comprise at least about 12 mounting interfaces or at least about 20 mounting interfaces.

194. A system for weighing a spray device, comprising: one or more processors, and memory storing one or more programs for execution by said one or more processor, said one or more programs comprising instructions to:(i) contact a collar coupled to said spray device to a surface of a body coupled to a weighing module, wherein a mass is cantilevered on said body; and(ii) weigh said spray device with a weighing module.

195. The system of claim 194, wherein said body comprises one or more mounting features configured to contact a surface of said collar.

196. The system of claim 195, wherein said one or more mounting features comprise one or more protrusions disposed on a surface of said body.

197. The system of any one of claims 194-196, wherein said instructions further comprise actuate said spray device with a spray device actuator thereby emitting a dose of said spray device collected by a collection vessel.

198. The system of claim 197, wherein said spray device is not in contact with said spray device actuator when said weighing module weighs said spray device.

199. The system of claim 197 or 198, wherein said spray device is not in contact with said weighing module when said spray device is actuated.

200. The system of any one of claims 197-199, wherein said instructions further comprise translate said collar with a lift actuator, wherein said lift actuator comprises one or more bodies, and wherein one or more surfaces of said one or more bodies are configured to couple to one or more surfaces of said collar.

201. The system of claim 200, wherein said body, said weighing module, said spray device actuator, said lift actuator, said spray device, said collar, or any combination thereof, is at least partially covered by an enclosure.

202. The system of claim 201, wherein said enclosure comprises a cover configured to seal an interior region of said enclosure from a region outside said enclosure.

203. The system of claim 202, wherein said enclosure comprises one or more fans fluidically coupled to said interior region of said enclosure and said region outside said enclosure.

204. The system of any one of claims 194-203, wherein said weighing module comprises one or more leveling features configured to level said weighing module.

205. The system of claim 204, wherein said one or more leveling features are adjustable.

206. The system of any one of claims 194-205, wherein said spray device comprises a nasal or oral spray device.

207. The system of any one of claims 194-206, wherein said mass is cantilevered on a first end of said body opposite a second end of said body where said collar contacts said body.

208. The system of any one of claims 194-207, wherein said collar comprises a collet.

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