External spraying agent and eye drop of compound oil nano-emulsion as well as preparation method thereof

A technology of sprays and eye drops, which is applied in the field of compound oil nanoemulsion sprays and eye drops for external use and its preparation, can solve the problems of increased pain, impact on vision and eye movement, and inaccurate dosage of patients, and achieve increased Targeting and adhesion, improving bioavailability, increasing the effect of drug absorption

CN101554369BInactive Publication Date: 2012-07-25陈亚玲 +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2012-07-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an external spraying agent and / or eye drop of compound oil nano-emulsion as well as preparation method thereof. The pH value of the spraying agent and / or eye drop is 3-9. The spraying agent and / or eye drop comprise the following components according to the weight portion: 5-15 of compound oil, 0.5-2.0 of phospholipid, 0.5-3.0 of propanetriol, sodium hydroxide and medicinalwater, wherein the compound oil comprises the following components: (1) zedoary turmeric oil and / or peppermint oil, and (2) soybean oil and / or castor oil. The mass ratio of the (1) and the (2) in thecompound oil is 1:99-30:70. The spraying agent of the compound oil nano-emulsion, which is prepared by the invention, is used for antibiosis, inflammation diminishing and wound healing in the processof curing burn and scald. The eye drop of the compound oil nano-emulsion is used for curing eye strain, xerophthalmia and eye inflammation.
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Description

technical field

[0001] The invention relates to a compound oil nanoemulsion spray and eye drops for external use and a preparation method thereof. Background technique

[0002] According to statistics, the annual incidence rate of burns in my country is 2%, that is, about 22 million people suffer from burns of varying degrees every year. Plus various scald patients, a total of about 30 million patients need treatment. Most of the external burn medicines on the market are traditional Chinese medicine ointments, and there are also common sprays; chemical medicines include powders, lotions, and film-coating agents; products are mainly ointments and powders, and the overall dosage form structure is still quite backward.

[0003] At present, there are still great disadvantages in the treatment of burns, and the treatment of large area burns is mostly followed by exposure and drying therapy. Clinical proof: using exposure and drying to control infection will damage the remaining...

Examples

Embodiment 1

[0039] Embodiment 1, preparation composite oil nanoemulsion spray and eye drops

[0040] (1) The distribution ratio of each component of the composite oil nanoemulsion is shown in Table 1 (made into 1000ml)

[0041] Table 1 The distribution ratio of each component of the composite oil nanoemulsion

[0042] component name

Weight percentage (%)

Feed amount (g)

effect

[0043] peppermint oil

0.1

1.0

Antibacterial anti-inflammatory

Soybean oil

9.9

99.0

Nutrients

egg yolk lecithin

1.2

12.0

Wetting agents, nutritional supplements,

carrier, emulsifier

1% NaOH

0.15

1.5

pH regulator

Glycerol

2.2

22.0

isotonicity regulator

Water for Injection

86.45

864.5

solvent

[0044] (2) Preparation of composite oil nanoemulsion spray and eye drops

[0045] a) Weigh 1.0 g of peppermint oil (sam...

Embodiment 2

[0054] Embodiment 2, preparation composite oil nanoemulsion spray and eye drops

[0055] (1) The distribution ratio of each component of the composite oil nanoemulsion is shown in Table 2 (made into 1000ml).

[0056] Table 2 The distribution ratio of each component of the composite oil nanoemulsion

[0057] component name

weight ratio(%)

Feed amount (g)

effect

Curcuma oil

0.5

5.0

Antibacterial anti-inflammatory

Soybean oil

9.5

95.0

Nutrients

egg yolk lecithin

1.5

15.0

Wetting agent, nutritional supplement

agent, carrier, emulsifier

1% NaOH

0.13

1.3

pH regulator

Glycerol

2.25

22.5

isotonicity regulator

Water for Injection

86.12

861.2

solvent

[0058] (2) Preparation of composite oil nanoemulsion spray and eye drops

[0059] a) Weigh 5.0 g of zedoary oil (Zhejiang Tianrui Pharmaceut...

Embodiment 3

[0068] Embodiment 3, preparation composite oil nanoemulsion spray and eye drops

[0069] (1) The distribution ratio of each component of the composite oil nanoemulsion is shown in Table 3 (made into 1000ml).

[0070] Table 3 The distribution ratio of each component of the composite oil nanoemulsion

[0071] component name

weight ratio(%)

Feed amount (g)

effect

Curcuma oil

1.0

10.0

Antibacterial anti-inflammatory

castor oil

5.0

50.0

D

Soy lecithin

0.5

5.0

Wetting agent, nutritional supplement

agent, carrier, emulsifier

1% NaOH

0.18

1.8

Emulsifier, pH adjuster

Glycerol

1.5

15.0

isotonicity regulator

Water for Injection

91.82

918.2

solvent

[0072] (2) Preparation of composite oil nanoemulsion spray and eye drops

[0073] a) Weigh 10.0 g of zedoary oil and 50.0 g of castor oil (Shang...