Oxidized sodium alginate/gelatin degradable hydrogel and preparation method thereof

Abstract

The invention relates to oxidized sodium alginate / gelatin degradable hydrogel and a preparation method thereof. The hydrogel is a composite hydrogel material prepared by blending human body-absorbable fibers, oxidized sodium alginate and gelatin, wherein, the oxidized sodium alginate and gelatin are used as a matrix, and the human body-absorbable fibers are dispersed in the matrix. The preparation method comprises the following steps: (1) carrying out oxidation treatment on the sodium alginate with an oxidizing agent so as to obtain oxidized sodium alginate and preparing an oxidized sodium alginate solution; (2) blending and defoaming the human body-absorbable fibers, a gelatin solution and the oxidized sodium alginate solution, standing an obtained mixture, cross-linking the mixture witha CaCl2 solution so as to obtain the hydrogel, and carrying out cutting processing, disinfection and packaging. The degradable hydrogel provided in the invention has good compatibility with human bodies, a high degradation rate and the effects of stopping bleeding and accelerating healing of wounds; the preparation method for the hydrogel provided in the invention has the advantages of short flow, simple operation, low cost, environmental friendliness and a high economic benefit.

Description

technical field

[0001] The invention belongs to the field of degradable hydrogel and its preparation, and in particular relates to an oxidized sodium alginate / gelatin degradable hydrogel and a preparation method thereof. Background technique

[0002] In the preparation of medical dressings, the degradability and compatibility of materials have always been the two major directions of research. With the development of science and technology, the requirements for visceral surgery materials are getting higher and higher, and the hemostatic performance of materials has gradually become an important issue to be considered. How to better solve these two problems has attracted more and more material circles and medical science. attention of researchers. So far, traditional gauze dressings are the most practical, most influential, and have been used for the longest time, and still occupy the largest market share. This type of dressing is generally made of cotton, soft sackcloth and...

Examples

Embodiment 1

[0032] (1) Take some PLA slices and dry them in a vacuum state at 100°C for 8 hours; then melt and extrude them through a screw extruder to obtain PLA primary multifilament fibers; after stretching, obtain PLA stretched fibers with a single filament diameter of 0.05mm, the number of multifilaments is 12; the fibers are cut into short fibers with an average length of 4mm.

[0033] (2) weigh sodium alginate with a balance and configure a solution with a mass fraction of 2% with distilled water; add potassium permanganate solution to make the concentration of potassium permanganate in the solution reach 5 × 10 -4 mol / L; use hydrochloric acid to adjust the pH of the solution to 3; stir in a dark room at room temperature for 10 minutes to fully oxidize; add 0.3% NaCl to the solution, and extract the oxidized sodium alginate with ethanol.

[0034] (3) Weigh gelatin with a balance and add it to distilled water, fully swell for 45 minutes, stir in a warm water bath at 60°C until compl...

Embodiment 2

[0038] (1) Take a number of PGLA slices and dry them under vacuum at 90°C for 15 hours; then melt and extrude them through a screw extruder to obtain PGLA primary single fibers; after stretching, obtain PGLA stretched single fibers with a diameter of 0.1 mm, the single fiber was cut into staple fibers with an average length of 3 mm long.

[0039] (2) weigh sodium alginate with a balance and configure a solution with a mass fraction of 2% with distilled water; add potassium permanganate solution to make the concentration of potassium permanganate in the solution reach 5 × 10 -4 mol / L; use hydrochloric acid to adjust the pH of the solution to 3; stir in a dark room at room temperature for 10 minutes to fully oxidize; add 0.3% NaCl to the solution, and extract the oxidized sodium alginate with ethanol.

[0040] (3) Weigh gelatin with a balance and add it to distilled water, fully swell for 45 minutes, stir in a warm water bath at 60°C until completely dissolved, and prepare a solut...

Embodiment 3

[0044] (1) Take a number of PBS slices and dry them under vacuum at 80°C for 10 hours; then melt and extrude them through a screw extruder to obtain PBS primary single fibers; after stretching, obtain PBS stretched single fibers with a diameter of 0.05 mm; the monofilaments were cut into short fibers with an average length of 4 mm long.

[0045] (2) weigh sodium alginate with a balance and configure a solution with a mass fraction of 2% with distilled water; add potassium permanganate solution to make the concentration of potassium permanganate in the solution reach 5 × 10 -4 mol / L; use hydrochloric acid to adjust the pH of the solution to 3; stir in a dark room at room temperature for 10 minutes to fully oxidize; add 0.3% NaCl to the solution, and extract the oxidized sodium alginate with ethanol.

[0046] (3) Weigh gelatin with a balance and add it to distilled water, fully swell for 45 minutes, stir in a warm water bath at 60°C until completely dissolved, and prepare a solu...

technical field

[0001] The invention belongs to the field of degradable hydrogel and its preparation, and in particular relates to an oxidized sodium alginate / gelatin degradable hydrogel and a preparation method thereof. Background technique

[0002] In the preparation of medical dressings, the degradability and compatibility of materials have always been the two major directions of research. With the development of science and technology, the requirements for visceral surgery materials are getting higher and higher, and the hemostatic performance of materials has gradually become an important issue to be considered. How to better solve these two problems has attracted more and more material circles and medical science. attention of researchers. So far, traditional gauze dressings are the most practical, most influential, and have been used for the longest time, and still occupy the largest market share. This type of dressing is generally made of cotton, soft sackcloth and...

Examples

Embodiment 1

[0032] (1) Take some PLA slices and dry them in a vacuum state at 100°C for 8 hours; then melt and extrude them through a screw extruder to obtain PLA primary multifilament fibers; after stretching, obtain PLA stretched fibers with a single filament diameter of 0.05mm, the number of multifilaments is 12; the fibers are cut into short fibers with an average length of 4mm.

[0033] (2) weigh sodium alginate with a balance and configure a solution with a mass fraction of 2% with distilled water; add potassium permanganate solution to make the concentration of potassium permanganate in the solution reach 5 × 10 -4 mol / L; use hydrochloric acid to adjust the pH of the solution to 3; stir in a dark room at room temperature for 10 minutes to fully oxidize; add 0.3% NaCl to the solution, and extract the oxidized sodium alginate with ethanol.

[0034] (3) Weigh gelatin with a balance and add it to distilled water, fully swell for 45 minutes, stir in a warm water bath at 60°C until compl...

Embodiment 2

[0038] (1) Take a number of PGLA slices and dry them under vacuum at 90°C for 15 hours; then melt and extrude them through a screw extruder to obtain PGLA primary single fibers; after stretching, obtain PGLA stretched single fibers with a diameter of 0.1 mm, the single fiber was cut into staple fibers with an average length of 3 mm long.

[0039] (2) weigh sodium alginate with a balance and configure a solution with a mass fraction of 2% with distilled water; add potassium permanganate solution to make the concentration of potassium permanganate in the solution reach 5 × 10 -4 mol / L; use hydrochloric acid to adjust the pH of the solution to 3; stir in a dark room at room temperature for 10 minutes to fully oxidize; add 0.3% NaCl to the solution, and extract the oxidized sodium alginate with ethanol.

[0040] (3) Weigh gelatin with a balance and add it to distilled water, fully swell for 45 minutes, stir in a warm water bath at 60°C until completely dissolved, and prepare a solut...

Embodiment 3

[0044] (1) Take a number of PBS slices and dry them under vacuum at 80°C for 10 hours; then melt and extrude them through a screw extruder to obtain PBS primary single fibers; after stretching, obtain PBS stretched single fibers with a diameter of 0.05 mm; the monofilaments were cut into short fibers with an average length of 4 mm long.

[0045] (2) weigh sodium alginate with a balance and configure a solution with a mass fraction of 2% with distilled water; add potassium permanganate solution to make the concentration of potassium permanganate in the solution reach 5 × 10 -4 mol / L; use hydrochloric acid to adjust the pH of the solution to 3; stir in a dark room at room temperature for 10 minutes to fully oxidize; add 0.3% NaCl to the solution, and extract the oxidized sodium alginate with ethanol.

[0046] (3) Weigh gelatin with a balance and add it to distilled water, fully swell for 45 minutes, stir in a warm water bath at 60°C until completely dissolved, and prepare a solu...

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