Application of compound SC-51089 to prepare medicaments for treating diabetes and complications

A technology of SC-51089, a compound, applied in the field of medicinal chemistry and pharmacotherapeutics, which can solve the problem of unclear signaling mechanism

CN103381161AInactive Publication Date: 2013-11-06SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2013-11-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an application of a compound SC-51089 to prepare an antagonist of a progesterone receptor (PR), and a new application of the compound to prepare medicaments for treating diabetes and complications thereof. As the selective antagonist of the progesterone receptor (PR), on one hand the compound has the function of protecting islet cells and preventing islet cells from function degeneration, on the other hand the compound helps to properly improve insulin secreting to avoid generation of hyperinsulinemia. Therefore, the compound SC-51089 is applicable to diseases such as diabetes and the complications thereof and the like.
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Description

technical field

[0001] The present invention relates to the fields of medicinal chemistry and pharmacotherapeutics, specifically, the use of compound SC-51089 as a progesterone receptor (PR) antagonist in the preparation of medicines for treating diabetes and its complications. Background technique

[0002] Due to the impact of high-fat diet, lack of exercise and other lifestyles, the incidence of diabetes is increasing day by day. Current medications do not provide adequate long-term glycemic control in most patients 1 However, even with the combination of drugs, it is still impossible to reverse the process from diabetes susceptibility to multiple organ failure and even life-threatening, such as concurrent cardiovascular disease, blindness, kidney failure and amputation.

[0003] Early diabetes is characterized by progressive deterioration of insulin sensitivity in insulin target tissues and peripheral insulin resistance. With the development of the disease, the function...