Drug composition for enhancing memory of people rapidly exposed to high altitude, and preparation method thereof

Abstract

The present invention discloses a drug composition for enhancing memory of people rapidly exposed to a high altitude. The drug composition comprises an active component and an auxiliary material, wherein the active component comprises taurine, ovolecithin, acetyl-L-carnitine, and huperzine a, and the auxiliary material comprises lactose, MCC and magnesium stearate, or comprises lactose and magnesium stearate. The drug composition has the following beneficial effects that: based on different mechanisms such as provision of essential nutrients for nerve cells, free radical removing, neurotransmitter acetylcholine precursor complementing, central cholinergic system regulation, and the like, a comprehensive effect is acted on human body, drug combination advantages are presented, and improvement of memory of people rapidly exposed to a high altitude is achieved.

Description

technical field

[0001] The invention relates to the field of medicines, in particular to a pharmaceutical composition for enhancing the memory of people rapidly advancing to plateaus and a preparation method thereof. Background technique

[0002] After entering the plateau, people living in the plains often cause a series of acute altitude sickness due to low air pressure and hypoxia, including dizziness, palpitation, nausea, insomnia, memory loss and other symptoms. The above symptoms are more obvious.

[0003] Both animal model experiments and clinical imaging studies of people rapidly entering high altitudes have shown that acute hypobaric hypoxia can lead to damage to brain hippocampal neurons. On the basis of such pathological changes, people who rapidly enter the plateau may experience cognitive dysfunction, including learning disabilities, memory difficulties, and attention deficits. And eventually lead to a significant decline in the level of vocational skills. ...

Examples

Embodiment 1

[0018] A pharmaceutical composition for enhancing the memory of people rapidly advancing to high altitudes, including active ingredients taurine, egg yolk lecithin, acetyl-L-carnitine and huperzine A totaling 300 mg; excipients lactose 124 mg, MCC 46 mg, magnesium stearate 8 mg, the active ingredients The ingredients, lactose, and MCC are mixed evenly, moistened with water, the wetted mixture is sieved and dried, sieved, magnesium stearate is added, mixed evenly, and tabletted.

[0019] Active ingredients per unit dosage form: 128mg taurine; 128mg egg yolk lecithin; 44mg acetyl-L-carnitine; 0.8mg huperzine A.

[0020] Prove the beneficial effect of medicine of the present invention below by pharmacodynamics test:

[0021] (1) Materials and methods

[0022] 1. Drugs:

[0023] The prepared pharmaceutical composition of embodiment 1;

[0024] Salidroside, purity >90% (HPLC).

[0025] 2. Screening and grouping of experimental animals:

[0026] Healthy male Sprague-Daw...

Embodiment 2

[0095] A pharmaceutical composition for enhancing the memory of people rapidly advancing to high altitudes, including active ingredients taurine, egg yolk lecithin, acetyl-L-carnitine and huperzine A in total 300 mg; excipients lactose 87 mg, magnesium stearate 5 mg, the active ingredients, The lactose is mixed evenly, moistened with water, the wetted mixture is sieved and dried, sieved, magnesium stearate is added, mixed evenly, and packed into capsules.

[0096] Active ingredients per unit dosage form: 128mg taurine; 128mg egg yolk lecithin; 44mg acetyl-L-carnitine; 0.8mg huperzine A.

technical field

[0001] The invention relates to the field of medicines, in particular to a pharmaceutical composition for enhancing the memory of people rapidly advancing to plateaus and a preparation method thereof. Background technique

[0002] After entering the plateau, people living in the plains often cause a series of acute altitude sickness due to low air pressure and hypoxia, including dizziness, palpitation, nausea, insomnia, memory loss and other symptoms. The above symptoms are more obvious.

[0003] Both animal model experiments and clinical imaging studies of people rapidly entering high altitudes have shown that acute hypobaric hypoxia can lead to damage to brain hippocampal neurons. On the basis of such pathological changes, people who rapidly enter the plateau may experience cognitive dysfunction, including learning disabilities, memory difficulties, and attention deficits. And eventually lead to a significant decline in the level of vocational skills. ...

Examples

Embodiment 1

[0018] A pharmaceutical composition for enhancing the memory of people rapidly advancing to high altitudes, including active ingredients taurine, egg yolk lecithin, acetyl-L-carnitine and huperzine A totaling 300 mg; excipients lactose 124 mg, MCC 46 mg, magnesium stearate 8 mg, the active ingredients The ingredients, lactose, and MCC are mixed evenly, moistened with water, the wetted mixture is sieved and dried, sieved, magnesium stearate is added, mixed evenly, and tabletted.

[0019] Active ingredients per unit dosage form: 128mg taurine; 128mg egg yolk lecithin; 44mg acetyl-L-carnitine; 0.8mg huperzine A.

[0020] Prove the beneficial effect of medicine of the present invention below by pharmacodynamics test:

[0021] (1) Materials and methods

[0022] 1. Drugs:

[0023] The prepared pharmaceutical composition of embodiment 1;

[0024] Salidroside, purity >90% (HPLC).

[0025] 2. Screening and grouping of experimental animals:

[0026] Healthy male Sprague-Daw...

Embodiment 2

[0095] A pharmaceutical composition for enhancing the memory of people rapidly advancing to high altitudes, including active ingredients taurine, egg yolk lecithin, acetyl-L-carnitine and huperzine A in total 300 mg; excipients lactose 87 mg, magnesium stearate 5 mg, the active ingredients, The lactose is mixed evenly, moistened with water, the wetted mixture is sieved and dried, sieved, magnesium stearate is added, mixed evenly, and packed into capsules.

[0096] Active ingredients per unit dosage form: 128mg taurine; 128mg egg yolk lecithin; 44mg acetyl-L-carnitine; 0.8mg huperzine A.