Polypeptide compound for removing wrinkles in eyes and preparation method of polypeptide compound

Abstract

The invention provides a polypeptide compound for removing wrinkles in eyes. The polypeptide compound, in percentage by mass, consists of the following components: 0.02-0.035% of acetyl hexapeptide-3, 0.001-0.01% of palmitoyl pentapeptide-3, 0.025-0.035% of palmitoyl tetrapeptide-7, 0.025-0.035% of tripeptide, 0.08-0.12% of dipeptide-2, 0.1-0.2% of acetyl tetrapeptide-5, 4-6% of glycerol, 0.2-0.4% of sodium hyaluronate, 0.3-0.5% of 1,2-hexanediol and the balance of purified water. Correspondingly, the invention also provides a preparation method of the compound. The polypeptide compound for removing wrinkles in eyes provided by the invention, applied to volunteers, is capable of taking a significant effect of relieving wrinkles in eyes, so that the average quantity of the wrinkles in eyes is reduced, the depth of the wrinkles in eyes is reduced, the smoothness of eye skin is enhanced, the coverage area of the wrinkles in eyes is reduced and the phenomenon of the wrinkles in eyes is significantly improved.

Description

Technical field

[0001] The present invention relates to a polypeptide complex used for wrinkle removal of eyes and a preparation method thereof. The complex is mainly used for eye skin and has the effects of removing wrinkles and delaying aging. Background technique

[0002] The skin around the eyes is the thinnest part of all skins of the human body. It is only a quarter of the thickness of the facial skin. There is almost no distribution of sebaceous glands and sweat glands. Therefore, it has no natural moisturizing ability, and it is not easy to store water. It is easy to cause dryness and dehydration. Weeks skin is very easy to age. With age, the eye skin is prone to wrinkles, expression lines, crow's feet, loss of elasticity and firmness, and sagging.

[0003] At present, there are many anti-wrinkle products commonly used, and their effects and effects are very different. Most products usually cannot improve skin metabolism, promote skin blood circulation, increase skin nutri...

Examples

Embodiment 1

[0023] (a) Add 70% pure water according to the proportion, heat to 80°C, add 0.3% 1,2-hexanediol, stir to dissolve, and then divide into two equal parts, namely A phase and B phase;

[0024] (b) Keep the temperature of phase A at 50°C, stir and add 0.4% sodium hyaluronate, continue to stir to dissolve and mix uniformly, then add 4% glycerin, continue to stir and mix uniformly, as phase I;

[0025] (c) 0.02% acetyl hexapeptide-3, 0.01% palmitoyl pentapeptide-3, 0.025% palmitoyl tetrapeptide-7, 0.035% tripeptide, 0.1% acetyl tetrapeptide-5 and 0.08 % Dipeptide-2 was added to phase B, stirred to dissolve and mixed evenly, filtered with a filter membrane with a filter hole of 0.45 μm, and the filtrate obtained was phase II;

[0026] (d) Add phase II to phase I under agitation, rinse the container of phase II with the remaining proportion of pure water, and add the rinse to phase I, stir and mix evenly;

[0027] (e) Adjust the pH value of the mixed solution with 15 wt% arginine to 6.0-7.0,...

Embodiment 2

[0029] (a) Add 80% pure water according to the proportion, heat to 80°C, add 0.5% 1,2-hexanediol, stir to dissolve, and then divide into two equal parts, namely A phase and B phase;

[0030] (b) Keep the temperature of phase A at 60°C, stir and add 0.4% sodium hyaluronate, continue to stir to dissolve and mix uniformly, then add 5% glycerin, continue to stir and mix uniformly, as phase I;

[0031] (c) 0.025% acetyl hexapeptide-3, 0.007% palmitoyl pentapeptide-3, 0.035% palmitoyl tetrapeptide-7, 0.035% tripeptide, 0.1% acetyl tetrapeptide-5 and 0.1 % Dipeptide-2 was added to phase B, stirred to dissolve and mixed evenly, filtered with a filter membrane with a filter hole of 0.45 μm, and the filtrate obtained was phase II;

[0032] (d) Add phase II to phase I under agitation, rinse the container of phase II with the remaining proportion of pure water, and add the rinse to phase I, stir and mix evenly;

[0033] (e) Adjust the pH of the mixed solution to 6.0-7.0 with 15 wt% arginine, and ...

Embodiment 3

[0035] (a) Add 80% pure water according to the proportion, heat to 80°C, add 0.4% 1,2-hexanediol, stir to dissolve, and then divide into two equal parts, namely A phase and B phase;

[0036] (b) Keep the temperature of phase A at 70°C, stir and add 0.2% sodium hyaluronate, continue to stir to dissolve and mix evenly, then add 6% glycerin, continue to stir and mix evenly, as phase I;

[0037] (c) 0.03% acetyl hexapeptide-3, 0.001% palmitoyl pentapeptide-3, 0.03% palmitoyl pentapeptide-7, 0.03% tripeptide, 0.15% acetyl tetrapeptide-5 and 0.12 % Dipeptide-2 was added to phase B, stirred to dissolve and mixed evenly, filtered with a filter membrane with a filter hole of 0.45 μm, and the filtrate obtained was phase II;

[0038] (d) Add phase II to phase I under agitation, rinse the container of phase II with the remaining proportion of pure water, and add the rinse to phase I, stir and mix evenly;

[0039] (e) Adjust the pH value of the mixed solution with 15 wt% arginine to 6.0-7.0, and t...

Technical field

[0001] The present invention relates to a polypeptide complex used for wrinkle removal of eyes and a preparation method thereof. The complex is mainly used for eye skin and has the effects of removing wrinkles and delaying aging. Background technique

[0002] The skin around the eyes is the thinnest part of all skins of the human body. It is only a quarter of the thickness of the facial skin. There is almost no distribution of sebaceous glands and sweat glands. Therefore, it has no natural moisturizing ability, and it is not easy to store water. It is easy to cause dryness and dehydration. Weeks skin is very easy to age. With age, the eye skin is prone to wrinkles, expression lines, crow's feet, loss of elasticity and firmness, and sagging.

[0003] At present, there are many anti-wrinkle products commonly used, and their effects and effects are very different. Most products usually cannot improve skin metabolism, promote skin blood circulation, increase skin nutri...

Examples

Embodiment 1

[0023] (a) Add 70% pure water according to the proportion, heat to 80°C, add 0.3% 1,2-hexanediol, stir to dissolve, and then divide into two equal parts, namely A phase and B phase;

[0024] (b) Keep the temperature of phase A at 50°C, stir and add 0.4% sodium hyaluronate, continue to stir to dissolve and mix uniformly, then add 4% glycerin, continue to stir and mix uniformly, as phase I;

[0025] (c) 0.02% acetyl hexapeptide-3, 0.01% palmitoyl pentapeptide-3, 0.025% palmitoyl tetrapeptide-7, 0.035% tripeptide, 0.1% acetyl tetrapeptide-5 and 0.08 % Dipeptide-2 was added to phase B, stirred to dissolve and mixed evenly, filtered with a filter membrane with a filter hole of 0.45 μm, and the filtrate obtained was phase II;

[0026] (d) Add phase II to phase I under agitation, rinse the container of phase II with the remaining proportion of pure water, and add the rinse to phase I, stir and mix evenly;

[0027] (e) Adjust the pH value of the mixed solution with 15 wt% arginine to 6.0-7.0,...

Embodiment 2

[0029] (a) Add 80% pure water according to the proportion, heat to 80°C, add 0.5% 1,2-hexanediol, stir to dissolve, and then divide into two equal parts, namely A phase and B phase;

[0030] (b) Keep the temperature of phase A at 60°C, stir and add 0.4% sodium hyaluronate, continue to stir to dissolve and mix uniformly, then add 5% glycerin, continue to stir and mix uniformly, as phase I;

[0031] (c) 0.025% acetyl hexapeptide-3, 0.007% palmitoyl pentapeptide-3, 0.035% palmitoyl tetrapeptide-7, 0.035% tripeptide, 0.1% acetyl tetrapeptide-5 and 0.1 % Dipeptide-2 was added to phase B, stirred to dissolve and mixed evenly, filtered with a filter membrane with a filter hole of 0.45 μm, and the filtrate obtained was phase II;

[0032] (d) Add phase II to phase I under agitation, rinse the container of phase II with the remaining proportion of pure water, and add the rinse to phase I, stir and mix evenly;

[0033] (e) Adjust the pH of the mixed solution to 6.0-7.0 with 15 wt% arginine, and ...

Embodiment 3

[0035] (a) Add 80% pure water according to the proportion, heat to 80°C, add 0.4% 1,2-hexanediol, stir to dissolve, and then divide into two equal parts, namely A phase and B phase;

[0036] (b) Keep the temperature of phase A at 70°C, stir and add 0.2% sodium hyaluronate, continue to stir to dissolve and mix evenly, then add 6% glycerin, continue to stir and mix evenly, as phase I;

[0037] (c) 0.03% acetyl hexapeptide-3, 0.001% palmitoyl pentapeptide-3, 0.03% palmitoyl pentapeptide-7, 0.03% tripeptide, 0.15% acetyl tetrapeptide-5 and 0.12 % Dipeptide-2 was added to phase B, stirred to dissolve and mixed evenly, filtered with a filter membrane with a filter hole of 0.45 μm, and the filtrate obtained was phase II;

[0038] (d) Add phase II to phase I under agitation, rinse the container of phase II with the remaining proportion of pure water, and add the rinse to phase I, stir and mix evenly;

[0039] (e) Adjust the pH value of the mixed solution with 15 wt% arginine to 6.0-7.0, and t...