A modular teaching and practice device for an aspirin production line

Abstract

The invention discloses a modular teaching practice device for an aspirin production line, comprising a common module, a reaction module and a recrystallization module which are connected together; the reaction module comprises a reactor, a crystallization reactor and a first mother liquid tank, the inlet of the reactor is connected with an acetic anhydride raw material tank through a pipeline connected with an anhydride pump, the outlet of the reactor is communicated with the inlet of the crystallization reactor through a pipeline connected with a bag filter, the outlet of the crystallization reactor is communicated with the inlet of the first mother liquid tank through a pipeline connected with a first centrifuge, and the outlet of the first mother liquid tank is communicated with the inlet of the reactor through a pipeline. The invention can modularize and proportionally manufacture and install the aspirin production line in a laboratory, facilitate practical teaching work, and can be freely assembled, so as to train students' hands-on ability and creativity, and greatly reduce the danger.

Description

Technical Field

[0001] The invention relates to the technical field of chemical experiment and practice teaching equipment, and in particular to a modular teaching practice device for an aspirin production line. Background Art

[0002] Aspirin, also known as acetylsalicylic acid and acetylsalicylic acid, is a long-standing antipyretic and analgesic drug that was created on March 6, 1899. It is mainly used to treat colds, fever, headaches, toothaches, joint pain, rheumatism, and can also inhibit platelet aggregation. It is used to prevent and treat ischemic heart disease, angina pectoris, cardiopulmonary infarction, and cerebral thrombosis. So far, aspirin has been used for a hundred years and has become one of the three classic drugs in the history of medicine. It is still the most widely used antipyretic, analgesic and anti-inflammatory drug in the world, and is also used as a standard preparation for comparing and evaluating other drugs. Aspirin production lines are often used in chemical practice teaching, but it is inconvenient to organize students to practice at manufacturers, and it is also dangerous. Therefore, it is of great significance to make a modular practice device that can be practiced in the laboratory based on the aspirin production line. At the same time, the entire practice device can be decomposed into different modules according to the process flow, which can be easily understood and freely combined. Summary of the invention

[0003] The problem to be solved by the present invention is to provide a modular teaching practice device for an aspirin production line in view of the above problems.

[0004] The technical solution of the present invention is: a modular teaching practice device for an aspirin production line, comprising a reaction module and a recrystallization module connected together;

[0005] The reaction module comprises a reactor, a crystallization kettle and a first mother liquid tank, the inlet of the reactor is connected to an acetic anhydride raw material tank through a pipeline connected to an anhydride pump, the outlet of the reactor is connected to the inlet of the crystallization kettle through a pipeline connected to a bag filter, the outlet of the crystallization kettle is connected to the inlet of the first mother liquid tank through a pipeline connected to a first centrifuge, and the outlet of the first mother liquid tank is connected to the inlet of the reactor through a pipeline;

[0006] The recrystallization module comprises an ethanol raw material tank, a recrystallization kettle and a second mother liquid tank, wherein the outlet of the ethanol raw material tank is connected to the inlet of the recrystallization kettle through a pipeline connected to an ethanol pump, and the outlet of the recrystallization kettle is connected to the inlet of the second mother liquid tank through a pipeline connected to a second centrifuge;

[0007] The reactor, the crystallization reactor, the first mother liquid tank, the ethanol raw material tank and the second mother liquid tank are all connected to vacuum via pipelines.

[0008] Preferably, the reaction module further comprises a neutralization kettle, the inlet of the neutralization kettle is connected to the outlet of the first mother liquid tank via a pipeline, and the neutralization kettle is also connected to a vacuum via a pipeline.

[0009] Preferably, the reaction kettle, the crystallization kettle, the neutralization kettle and the recrystallization kettle are respectively connected to a first condenser, a second condenser, a third condenser and a fourth condenser through pipelines.

[0010] Preferably, the reaction module and the recrystallization module are both provided with a softened water upper pipe, a circulating water upper pipe, a circulating water return pipe, a compressed air pipeline, a vacuum pipeline, a cold water upper pipe, a cold water return pipe, a hot water upper pipe, a hot water return pipe and a sewage pipe; the softened water upper pipe, the circulating water upper pipe, the circulating water return pipe, the compressed air pipeline, the vacuum pipeline, the cold water upper pipe, the cold water return pipe, the hot water upper pipe, the hot water return pipe and the sewage pipe of the reaction module are respectively detachably connected with the softened water upper pipe, the circulating water upper pipe, the circulating water return pipe, the compressed air pipeline, the vacuum pipeline, the cold water upper pipe, the cold water return pipe, the hot water upper pipe, the hot water return pipe and the sewage pipe of the recrystallization module; the hot water upper pipe and the hot water return pipe are connected to a heating circulation pump via a pipeline, and the cold water upper pipe and the cold water return pipe are connected to a second refrigeration circulation pump via a pipeline.

[0011] Preferably, the inlets of the reactor, the crystallization reactor and the neutralization reactor are all connected to the softened water upper water pipe of the reaction module through a pipeline, the inlet of the recrystallization reactor is connected to the softened water upper water pipe of the recrystallization module through a pipeline, the circulating water inlet and outlet of the first condenser, the second condenser and the third condenser are respectively connected to the circulating water upper water pipe and the circulating water return pipe of the reaction module, and the circulating water inlet and outlet of the fourth condenser are respectively connected to the circulating water upper water pipe and the circulating water return pipe of the reaction module.

[0012] Preferably, the reactor, the crystallization reactor, the neutralization reactor and the first mother liquid tank are respectively connected to the vacuum pipeline of the reaction module through pipelines, the ethanol raw material tank and the second mother liquid tank are connected to the vacuum pipeline of the recrystallization module through pipelines, the outlets of the reactor, the crystallization reactor, the neutralization reactor and the first mother liquid tank are all connected to the sewage pipeline of the reaction module through pipelines, and the outlets of the ethanol raw material tank, the recrystallization reactor and the second mother liquid tank are all connected to the sewage pipeline of the recrystallization module through pipelines.

[0013] Preferably, the pipeline between the outlet of the crystallization kettle and the first centrifuge is connected to the compressed air pipeline of the reaction module through a pipeline, and the pipeline between the outlet of the recrystallization kettle and the second centrifuge is connected to the compressed air pipeline of the recrystallization module through a pipeline.

[0014] Preferably, the recrystallization module is also provided with a discharge pipe and a reflux pipe, the recrystallization module is connected to a distillation module, the outlet of the second mother liquid tank is connected to the discharge pipe through a pipe, the ethanol raw material tank is connected to the reflux pipe through a pipe, the discharge pipe is connected to the raw material tank in the distillation module through a pipe, and the reflux pipe is connected to the bottom liquid tank in the distillation module.

[0015] Preferably, it also includes a common module, which includes a tap water supply pipe, a softened water supply pipe, a circulating water supply pipe, a circulating water return pipe, a compressed air pipeline, a vacuum pipeline, and a sewage pipeline. The softened water supply pipe, the circulating water supply pipe, the circulating water return pipe, the compressed air pipeline, the vacuum pipeline, and the sewage pipeline of the common module are detachably connected with the softened water supply pipe, the circulating water supply pipe, the circulating water return pipe, the compressed air pipeline, the vacuum pipeline, and the sewage pipeline of the reaction module respectively. The common module is provided with a softened water column, a salt box connected to the softened water column, a softened water tank, a circulating water tank, an air buffer tank, and a vacuum buffer tank. The tap water supply pipe The softened water column is connected to the softened water column through a pipeline, the softened water column is connected to the inlet of the softened water tank through a pipeline, the outlet of the softened water tank is connected to the softened water supply pipe through a pipeline connected to the softened water pump, the outlet of the circulating water tank is connected to the circulating water supply pipe through a pipeline connected to the circulating water pump, the circulating water return pipe is connected to the inlet of the circulating water tank through a pipeline, the air buffer tank is connected to the air compressor and the compressed air pipeline respectively through pipelines, the vacuum buffer tank is connected to the vacuum pump and the vacuum pipeline respectively through pipelines, and the common module is also provided with a first refrigeration circulation pump, and the first refrigeration circulation pump is connected to the circulating water tank through two pipelines.

[0016] Preferably, the above pipelines are all connected with valves.

[0017] The beneficial effects of the present invention are:

[0018] The present invention can modularize and proportion the aspirin production line and install it in a laboratory, which is convenient for practical teaching work and can be freely assembled to train students' hands-on ability and creativity, and the danger is greatly reduced.

[0019] In the reaction module, vacuum can be used to transfer materials, which is convenient and quick, and compressed air can be used to clean the pipes above the centrifuge to avoid blockage. In addition, a bag filter is installed on the pipe connected to the reactor outlet to filter out large pieces of material to prevent the vacuum from being unable to draw away and thus clogging the pipe. The reactor, crystallization kettle, and neutralization kettle are all equipped with condensers to condense and reflux the volatile gases. Students can do it themselves, fully understand the actual production process, and understand the reaction principles of each stage.

[0020] A separate tap water supply pipe is set in the public module, which is arranged separately from the circulating water supply pipe and the circulating water return pipe. This is convenient for adjusting the position of the tap water supply pipe according to the position of the on-site tap water interface, and will not affect the arrangement of the circulating water supply pipe and the circulating water return pipe. A first refrigeration circulation pump is also set in the public module. There are many students in the school, and the practical equipment needs to run for a long time. The temperature of the circulating water will continue to rise. After a period of time, the circulating water temperature is too high to have a cooling effect. Students will forget to replace the circulating water, which affects the practical effect. The use of the refrigeration circulation pump will avoid the circulating water temperature from rising, and will also let students understand the role of the refrigeration circulation pump, which can deepen students' understanding. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is the process principle diagram of the present invention;

[0022] Figure 2 It is a structural schematic diagram of the present invention;

[0023] Figure 3 It is a structural diagram of a common module;

[0024] Figure 4 It is a structural schematic diagram of the reaction module;

[0025] Figure 5 It is a structural schematic diagram of the recrystallization module;

[0026] Figure 6 It is a structural schematic diagram of the distillation module;

[0027] In the figure: 1. tap water supply pipe, 1-1. softened water supply pipe, 1-2. circulating water supply pipe, 1-3. circulating water return pipe, 1-4. cold water supply pipe, 1-5. cold water return pipe, 1-6. hot water supply pipe, 1-7. hot water return pipe, 2. compressed air pipeline, 3. vacuum pipeline, 4. sewage pipeline, 5. discharge pipeline, 6. return pipeline, 7. heating circulation pump, gy1. first refrigeration circulation pump, gy2. salt box, gy3. softened water column, gy4. softened water tank, gy5. softened water pump, gy6. circulating water tank, gy7. air compressor, g y8. Air buffer tank, gy9. Vacuum buffer tank, gy10. Vacuum pump, 8. Second refrigeration circulation pump, fy1. Acetic anhydride raw material tank, fy2. Anhydride pump, fy3. Reactor, fy4. Crystallization kettle, fy5. First centrifuge, fy6. First mother liquid tank, fy7. Neutralization kettle, fy8. First condenser, fy9. Second condenser, fy10. Third condenser, fy11. Bag filter, c1. Ethanol raw material tank, c2. Ethanol pump, c3. Recrystallization kettle, c4. Second centrifuge, c5. Second mother liquid tank, c6. Fourth condenser. DETAILED DESCRIPTION

[0028] The specific implementation of the present invention is shown in Figure 1-6 :

[0029] A modular teaching practice device for an aspirin production line, such as Figure 1-6 , including a reaction module and a recrystallization module docked together;

[0030] The reaction module includes a reactor fy3, a crystallization reactor fy4, a neutralization reactor fy7 and a first mother liquid tank fy6, the inlet of the reactor fy3 is connected to the acetic anhydride raw material tank fy1 through a pipeline connected to the anhydride pump fy2, the outlet of the reactor fy3 is connected to the inlet of the crystallization reactor fy4 through a pipeline connected to the bag filter fy11, the outlet of the crystallization reactor fy4 is connected to the inlet of the first mother liquid tank fy6 through a pipeline connected to the first centrifuge fy5, and the outlet of the first mother liquid tank fy6 is connected to the inlet of the reactor fy3 through a pipeline;

[0031] The recrystallization module includes an ethanol raw material tank c1, a recrystallization kettle c3 and a second mother liquid tank c5, the outlet of the ethanol raw material tank c1 is connected to the inlet of the recrystallization kettle c3 through a pipeline connected to the ethanol pump c2, and the outlet of the recrystallization kettle c3 is connected to the inlet of the second mother liquid tank c5 through a pipeline connected to the second centrifuge c4;

[0032] Reactor fy3, crystallizer fy4, first mother liquid tank fy6, ethanol raw material tank c1 and second mother liquid tank c5 are all connected to vacuum via pipelines;

[0033] The inlet of the neutralization kettle fy7 is connected to the outlet of the first mother liquid tank fy6 through a pipeline, and the neutralization kettle fy7 is also connected to a vacuum through a pipeline;

[0034] The reaction kettle fy3, the crystallization kettle fy4, the neutralization kettle fy7 and the recrystallization kettle c3 are respectively connected to the first condenser fy8, the second condenser fy9, the third condenser fy10 and the fourth condenser c6 through pipelines.

[0035] In the practical device, the reaction module and the recrystallization module are both provided with a softened water supply pipe 1-1, a circulating water supply pipe 1-2, a circulating water return pipe 1-3, a compressed air pipeline 2, a vacuum pipeline 3, a cold water supply pipe 1-4, a cold water return pipe 1-5, a hot water supply pipe 1-6, a hot water return pipe 1-7 and a sewage pipeline 4. The softened water supply pipe 1-1, the circulating water supply pipe 1-2, the circulating water return pipe 1-3, the compressed air pipeline 2, the vacuum pipeline 3, the cold water supply pipe 1-4, the cold water return pipe 1-5, the hot water supply pipe 1- 6. The hot water return pipe 1-7 and the sewage pipe 4 are respectively detachably connected to the softened water supply pipe 1-1, the circulating water supply pipe 1-2, the circulating water return pipe 1-3, the compressed air pipe 2, the vacuum pipe 3, the cold water supply pipe 1-4, the cold water return pipe 1-5, the hot water supply pipe 1-6, the hot water return pipe 1-7 and the sewage pipe 4 of the recrystallization module; the hot water supply pipe 1-6 and the hot water return pipe 1-7 are connected to the heating circulation pump 7 through a pipe, and the cold water supply pipe 1-4 and the cold water return pipe 1-5 are connected to the second refrigeration circulation pump 8 through a pipe.

[0036] In the reaction module of the practical device, the inlets of the reactor fy3, the crystallization reactor fy4 and the neutralization reactor fy7 are connected to the softened water upper water pipe 1-1 of the reaction module through a pipeline, the inlet of the recrystallization reactor c3 is connected to the softened water upper water pipe 1-1 of the recrystallization module through a pipeline, the circulating water inlet and outlet of the first condenser fy8, the second condenser fy9 and the third condenser fy10 are respectively connected to the circulating water upper water pipe 1-2 and the circulating water return pipe 1-3 of the reaction module, and the circulating water inlet and outlet of the fourth condenser c6 are respectively connected to the circulating water upper water pipe 1-2 and the circulating water return pipe 1-3 of the reaction module.

[0037] In this practical device, the reactor fy3, the crystallization reactor fy4, the neutralization reactor fy7, and the first mother liquid tank fy6 are respectively connected to the vacuum pipe 3 of the reaction module through pipes, the ethanol raw material tank c1 and the second mother liquid tank c5 are connected to the vacuum pipe 3 of the recrystallization module through pipes, the outlets of the reactor fy3, the crystallization reactor fy4, the neutralization reactor fy7, and the first mother liquid tank fy6 are all connected to the sewage pipe 4 of the reaction module through pipes, and the outlets of the ethanol raw material tank c1, the recrystallization reactor c3, and the second mother liquid tank c5 are all connected to the sewage pipe 4 of the recrystallization module through pipes.

[0038] In the practical device, the pipeline between the outlet of the crystallization kettle fy4 and the first centrifuge fy5 is connected to the compressed air pipeline 2 of the reaction module through a pipeline, the pipeline between the outlet of the recrystallization kettle c3 and the second centrifuge c4 is connected to the compressed air pipeline 2 of the recrystallization module through a pipeline, the pipeline between the outlet of the crystallization kettle fy4 and the first centrifuge fy5 is connected to the softened water upper water pipe 1-1 of the reaction module through a pipeline, the pipeline between the outlet of the recrystallization kettle c3 and the second centrifuge c4 is connected to the softened water upper water pipe 1-1 of the recrystallization module through a pipeline, the heat exchange jacket outside the reactor fy3 is respectively connected to the hot water upper water pipe 1-6 and the hot water return pipe 1-7 of the reaction module, and the heat exchange jacket outside the reactor fy3 is also respectively connected to the circulating water upper water pipe 1-2 and the circulating water return pipe 1-2 of the reaction module. The circulating water return pipe 1-3 is connected, the heat exchange jacket outside the crystallization kettle fy4 is connected with the cold water upper water pipe 1-4 and the cold water return pipe 1-5 of the reaction module respectively, the heat exchange jacket outside the neutralization kettle fy7 is connected with the circulating water upper water pipe 1-2 and the circulating water return pipe 1-3 of the reaction module respectively, the heat exchange jacket outside the recrystallization kettle c3 is connected with the hot water upper water pipe 1-6 and the hot water return pipe 1-7 of the recrystallization module respectively, the heat exchange jacket outside the recrystallization kettle c3 is also connected with the cold water upper water pipe 1-4 and the cold water return pipe 1-5 of the recrystallization module respectively, the heat exchange jackets outside the reaction kettle fy3, the crystallization kettle fy4 and the neutralization kettle fy7 are respectively connected with the sewage pipe 4 of the reaction module through pipelines, and the heat exchange jacket outside the recrystallization kettle c3 is connected with the sewage pipe 4 of the recrystallization module through pipelines.

[0039] In this practical device, the recrystallization module is also provided with a discharge pipe 5 and a reflux pipe 6. The recrystallization module is connected to the distillation module. The outlet of the second mother liquid tank c5 is connected to the discharge pipe 5 through a pipe, the ethanol raw material tank c1 is connected to the reflux pipe 6 through a pipe, the discharge pipe 5 is connected to the raw material tank in the distillation module through a pipe, and the reflux pipe 6 is connected to the bottom liquid tank in the distillation module.

[0040] The practice device also includes a common module, which includes a tap water supply pipe 1, a softened water supply pipe 1-1, a circulating water supply pipe 1-2, a circulating water return pipe 1-3, a compressed air pipeline 2, a vacuum pipeline 3, and a sewage pipeline 4. The softened water supply pipe 1-1, the circulating water supply pipe 1-2, the circulating water return pipe 1-3, the compressed air pipeline 2, the vacuum pipeline 3, and the sewage pipeline 4 of the common module are detachably connected with the softened water supply pipe 1-1, the circulating water supply pipe 1-2, the circulating water return pipe 1-3, the compressed air pipeline 2, the vacuum pipeline 3, and the sewage pipeline 4 of the reaction module respectively. The common module is provided with a softened water column gy3, a salt box gy2 connected to the softened water column gy3, a softened water tank gy4, a circulating water tank gy6, an air buffer tank gy8, and a vacuum buffer tank gy9. The tap water supply pipe 1 is connected to the reaction module through a pipeline. The softened water column gy3 is connected, the softened water column gy3 is connected to the inlet of the softened water tank gy4 through a pipeline, the outlet of the softened water tank gy4 is connected to the softened water supply pipe 1-1 through a pipeline connected to the softened water pump gy5, the outlet of the circulating water tank gy6 is connected to the circulating water supply pipe 1-2 through a pipeline connected to the circulating water pump, the circulating water return pipe 1-3 is connected to the inlet of the circulating water tank gy6 through a pipeline, the air buffer tank gy8 is connected to the air compressor gy7 and the compressed air pipeline 2 through pipelines, the vacuum buffer tank gy9 is connected to the vacuum pump gy10 and the vacuum pipeline 3 through pipelines, the common module is also provided with a first refrigeration circulation pump gy1, the first refrigeration circulation pump gy1 is connected to the circulating water tank gy6 through two pipelines, the tap water supply pipe 1 and the softened water supply pipe 1-1 are both connected to the circulating water tank through pipelines.

[0041] Each pipeline of the practical device is connected with a valve.

[0042] The present invention can modularize and proportion the aspirin production line and install it in a laboratory, which is convenient for practical teaching work and can be freely assembled to train students' hands-on ability and creativity, and the danger is greatly reduced.

[0043] In the reaction module, acetic anhydride solution is added to the acetic anhydride raw material tank fy1, salicylic acid is added to the reactor fy3, the reactor fy3 and the anhydride pump fy2 are turned on, the acetic anhydride raw material tank is added to the reactor fy3 through the anhydride pump fy2, and concentrated sulfuric acid is added to the reactor fy3 through the constant pressure funnel on the reactor fy3, the heating circulation pump is turned on, the valves VA206 and VA207 on the pipeline connecting the heating circulation pump with the hot water supply pipe 1-6 and the hot water return pipe 1-7 are opened, and the valves VA209 and VA207 on the pipeline connecting the heat exchange jacket on the reactor fy3 with the hot water supply pipe 1-6 and the hot water return pipe 1-7 are opened. A211 is opened respectively, and valves VA208 and VA212 on the pipeline connecting the heat exchange jacket on the reactor fy3 with the circulating water upper pipe 1-2 and the circulating water return pipe 1-3 are kept closed to heat the reactor fy3. The valves on the pipeline connecting the first condenser fy8 with the circulating water upper pipe 1-2 and the circulating water return pipe 1-3 are opened to pass the circulating water to condense the volatilized gas of the reactor fy3 and reflux it into the reactor fy3. When the reaction temperature rises to 75°C, observe the reaction phenomenon, and adjust the reaction temperature in time by adjusting valves VA209 and VA211 to ensure that the temperature does not exceed 80°C. Observe the reflux phenomenon. The reaction is maintained for 40-50 minutes. When the reaction time is up, the heating is stopped, the valves VA209 and VA211 are closed, the valve VA210 on the pipe connecting the heat exchange jacket and the sewage pipe is opened to discharge the hot water in the heat exchange jacket, the valves VA208 and VA212 are opened, and circulating water is introduced into the heat exchange jacket of the reactor fy3 to cool the reactor fy3; when the reaction temperature drops to between 30 and 40°C, the discharge valves VA201 and VA202 are opened, the vacuum solenoid valve VA215 is opened, and the liquid material in the reactor fy3 is poured into the crystallization reactor fy4 through vacuum, and the second refrigeration circulation pump 8 is turned on. Open the valves VA223 and VA218 of the connecting pipes between the heat exchange jacket of the crystallizer fy4 and the hot and cold water pipes and the cold water return pipe 1-5, and introduce circulating cold water into the heat exchange jacket of the crystallizer fy4 to cool it down. Open the valve on the pipeline connecting the softened water pipe 1-1 to the crystallizer fy4, and introduce a small amount of softened water into the crystallizer fy4 to hydrolyze the excess acetic anhydride. Add softened water in small amounts and multiple times. Pay attention to the temperature change and cool it down in time during the water addition process; set the speed to about 20-30rpm, continue to introduce cold water to cool it down, and precipitate crystals; after the crystals are precipitated, open the vacuum system and keep the pressure of the vacuum buffer tank gy9 at -0.05MPa, open the valve VA216 on the pipe connecting the first mother liquid tank fy6 and the vacuum pipe 3, start the first centrifuge fy5, open the discharge valves VA219 and VA221, and start centrifugal filtration; the mother liquid enters the mother liquid tank V202, passes through the vacuum system, opens the valve VA217 on the pipe connecting the neutralization kettle fy7 and the vacuum pipe 3, and pours the mother liquid into the neutralization kettle fy7, adds the prepared alkali solution for neutralization reaction, and discharges for environmental protection; the valve on the pipe connecting the softened water upper water pipe 1-1 between the valves VA219 and VA221 can also be opened, and a small amount of softened water is introduced to wash the crude aspirin; the mother liquid in the first mother liquid tank fy6 can also be poured into the reactor fy3 by opening the vacuum solenoid valve VA214 on the pipe connecting the reactor fy3 and the vacuum pipe 3, and the mother liquid is poured into the reactor fy3 for secondary reaction. .

[0044] In the recrystallization module, the crude aspirin prepared by the reaction module is added to the recrystallization kettle c3, and the crude aspirin is crystallized again by ethanol. The working process is the same as the working process of crystallization in the reaction module. The recrystallization module is also provided with a discharge pipe 5 and a reflux pipe 6. The recrystallization module is connected with the distillation module. The outlet of the second mother liquid tank c5 is connected with the discharge pipe 5 through a pipe, and the ethanol raw material tank c1 is connected with the reflux pipe 6 through a pipe. The discharge pipe 5 is connected with the raw material tank in the distillation module through a pipe, and the reflux pipe 6 is connected with the bottom liquid tank in the distillation module. The mother liquid in the second mother liquid tank c5 is discharged to the raw material tank in the distillation module through the discharge pipe 5. After distillation, ethanol is produced. The ethanol produced by the distillation flows through the reflux pipe 6 and returns to the ethanol raw material tank c1 by opening the vacuum solenoid valve VA306 on the pipe connecting the ethanol raw material tank c1 and the vacuum pipe 3. For the specific working process of the distillation module, please refer to the application number: 201810481173 .8. The Chinese invention patent named "Multifunctional fine chemical production line practice device" has publicly described the distillation module.

[0045] In the common module, tap water passes through the softening water column gy3 to prepare softened water and is stored in the softened water tank gy4. The circulating water can use the prepared softened water or directly use tap water, which can be set according to needs. The softened water tank gy4 is connected to the softened water supply pipe 1-1 through the softening water pump gy5. The circulating water tank gy6 is connected to the circulating water supply pipe 1-2 and the circulating water return pipe 1-3 through the circulating water pump to provide softened water and circulating water for subsequent modules. The circulating water tank gy6 is also connected to the first refrigeration circulation pump gy1 to maintain the low temperature state of the circulating water. The compressed air buffer tank gy8 and the vacuum buffer tank gy9 are respectively connected to the air compressor gy7 and the vacuum pump gy10. The compressed air buffer tank gy8 and the vacuum buffer tank gy9 are also connected to the compressed air pipeline 2 and the vacuum pipeline 3 through pipelines respectively. The compressed air buffer tank gy8 and the vacuum buffer tank gy9 provide stable compressed air source and vacuum source for subsequent processes respectively.

[0046] In this practical device, each tank is connected to the sewage pipe through a pipe for easy cleaning.

Claims

1. A modular teaching practice device for an aspirin production line, characterized in that: It includes a reaction module and a recrystallization module that are docked together; The reaction module comprises a reactor, a crystallization kettle and a first mother liquid tank, the inlet of the reactor is connected to an acetic anhydride raw material tank through a pipeline connected to an anhydride pump, the outlet of the reactor is connected to the inlet of the crystallization kettle through a pipeline connected to a bag filter, the outlet of the crystallization kettle is connected to the inlet of the first mother liquid tank through a pipeline connected to a first centrifuge, and the outlet of the first mother liquid tank is connected to the inlet of the reactor through a pipeline; The recrystallization module comprises an ethanol raw material tank, a recrystallization kettle and a second mother liquid tank, wherein the outlet of the ethanol raw material tank is connected to the inlet of the recrystallization kettle through a pipeline connected to an ethanol pump, and the outlet of the recrystallization kettle is connected to the inlet of the second mother liquid tank through a pipeline connected to a second centrifuge; The reactor, the crystallization reactor, the first mother liquid tank, the ethanol raw material tank and the second mother liquid tank are all connected to the vacuum through pipelines, the reaction module also includes a neutralization reactor, the inlet of the neutralization reactor is connected to the outlet of the first mother liquid tank through a pipeline, the neutralization reactor is also connected to the vacuum through a pipeline, the reactor, the crystallization reactor, the neutralization reactor and the recrystallization reactor are respectively connected to the first condenser, the second condenser, the third condenser and the fourth condenser through pipelines, the reaction module and the recrystallization module are both provided with a softened water upper water pipe, a circulating water upper water pipe, a circulating water return pipe, a compressed air pipeline, a vacuum pipeline, a cold water upper water pipe, a cold water return pipe, a hot water upper water pipe, a hot water return pipe and a sewage pipeline, the softened water upper water pipe, the circulating water upper water pipe, the circulating water return pipe, the compressed air pipeline, the vacuum pipeline, the cold water upper water pipe, the cold water return pipe, the hot water upper water pipe, the hot water return pipe and the sewage pipeline of the reaction module are respectively The first condenser, the second condenser and the third condenser are respectively connected with the circulating water upper pipe and the circulating water return pipe of the reaction module, the circulating water inlet and outlet of the fourth condenser are respectively connected with the circulating water upper pipe and the circulating water return pipe of the reaction module, the hot water upper pipe and the cold water return pipe are connected with the heating circulation pump through a pipe, and the cold water upper pipe and the cold water return pipe are connected with the second refrigeration circulation pump through a pipe.

2. The modular teaching practice device for an aspirin production line according to claim 1, characterized in that: The reactor, the crystallization reactor, the neutralization reactor and the first mother liquid tank are respectively connected to the vacuum pipeline of the reaction module through pipelines, the ethanol raw material tank and the second mother liquid tank are connected to the vacuum pipeline of the recrystallization module through pipelines, the outlets of the reactor, the crystallization reactor, the neutralization reactor and the first mother liquid tank are all connected to the sewage pipeline of the reaction module through pipelines, and the outlets of the ethanol raw material tank, the recrystallization reactor and the second mother liquid tank are all connected to the sewage pipeline of the recrystallization module through pipelines.

3. The modular teaching practice device for an aspirin production line according to claim 2, characterized in that: The pipeline between the outlet of the crystallization kettle and the first centrifuge is connected to the compressed air pipeline of the reaction module through a pipeline, and the pipeline between the outlet of the recrystallization kettle and the second centrifuge is connected to the compressed air pipeline of the recrystallization module through a pipeline.

4. The modular teaching practice device for an aspirin production line according to claim 3, characterized in that: The recrystallization module is also provided with a discharge pipe and a reflux pipe. The recrystallization module is connected to the distillation module. The outlet of the second mother liquid tank is connected to the discharge pipe through a pipe, the ethanol raw material tank is connected to the reflux pipe through a pipe, the discharge pipe is connected to the raw material tank in the distillation module through a pipe, and the reflux pipe is connected to the bottom liquid tank in the distillation module.

5. The modular teaching practice device for an aspirin production line according to claim 4, characterized in that: It also includes a common module, which includes a tap water supply pipe, a softened water supply pipe, a circulating water supply pipe, a circulating water return pipe, a compressed air pipeline, a vacuum pipeline, and a sewage pipeline. The softened water supply pipe, the circulating water supply pipe, the circulating water return pipe, the compressed air pipeline, the vacuum pipeline, and the sewage pipeline of the common module are detachably connected to the softened water supply pipe, the circulating water supply pipe, the circulating water return pipe, the compressed air pipeline, the vacuum pipeline, and the sewage pipeline of the reaction module respectively. The common module is provided with a softened water column, a salt box connected to the softened water column, a softened water tank, a circulating water tank, an air buffer tank, and a vacuum buffer tank. The tap water supply pipe is connected to the reaction module through a softened water column. A pipeline is connected to the softened water column, and the softened water column is connected to the inlet of the softened water tank through a pipeline, the outlet of the softened water tank is connected to the softened water supply pipe through a pipeline connected to the softened water pump, the outlet of the circulating water tank is connected to the circulating water supply pipe through a pipeline connected to the circulating water pump, the circulating water return pipe is connected to the inlet of the circulating water tank through a pipeline, the air buffer tank is connected to the air compressor and the compressed air pipeline respectively through pipelines, the vacuum buffer tank is connected to the vacuum pump and the vacuum pipeline respectively through pipelines, and the common module is also provided with a first refrigeration circulation pump, and the first refrigeration circulation pump is connected to the circulating water tank through two pipelines.

6. The modular teaching practice device for an aspirin production line according to any one of claims 1 to 5, characterized in that: The pipelines are all connected with valves.

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