A novel s-(-)-ornidazol disodium phosphate hydrate, a preparation and use thereof
By developing levoornidazole phosphate disodium heptahydrate with a stable spatial structure, the problems of ornidazole drug central toxicity and insufficient hydrate stability were solved, achieving a longer shelf life and safer anti-oxidative bacterial infection. Therapeutic effect.
Patent Information
- Application Number
- CN201910115085.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2019-02-14
- Publication Date
- 2019-05-21
- Estimated Expiration
- 2039-02-14
AI Technical Summary
Existing ornidazole drugs have central toxicity problems, and the stability of their hydrate crystal forms is insufficient, which affects the shelf life and safety of the drug.
A new levoornidazole phosphate disodium heptahydrate was developed, which has a stable spatial structure. Through specific preparation methods and administration forms, including gastrointestinal administration, intravenous administration, subcutaneous administration, etc., Form stable pharmaceutical compositions such as tablets, freeze-drying, water shots, injections, etc.
The new hydrate has better stability, extends the shelf life of the product, and shows strong efficacy in the treatment of sensitive protozoa and anti-oxidative bacterial infections, significantly reducing the risk of toxicity to the central nervous system and ensuring the safety of the drug sex and effectiveness.