A biochemical immunoassay analyzer
By using spectroscopic components in the biochemical immunoassay device to divide the light into multiple beams and inject into multiple colorimetric components, the problem of inefficiency in the prior art is solved, and the simultaneous analysis of multiple biological samples is realized, and the work efficiency is improved. And reduce costs.
Patent Information
- Application Number
- CN201910188779.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2019-03-13
- Publication Date
- 2025-02-18
- Estimated Expiration
- 2039-03-13
AI Technical Summary
The existing biochemical immunoassay devices are inefficient and cannot analyze multiple biological samples at the same time, resulting in long wait times for patients and increasing the cost and space occupancy of the hospital.
A biochemical immunoassay device is designed, using light source components, spectroscopic components and multiple colorimetric components. Through the spectroscopic components, monochromatic light is divided into multiple beams and injected into different colorimetric components to achieve simultaneous analysis of multiple biological samples.
It greatly improves the working efficiency of the biochemical immunoassay device, and can analyze multiple biological samples at the same time, reducing patient waiting time and reducing hospital operating costs.
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Figure CN109781971B_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the field of medical equipment, and in particular to a biochemical immunoassay analyzer. Background Art
[0002] In modern medicine, it is a very common technical means to infer the physiological condition of the source of biological samples by measuring the content of specific biochemical substances in biological samples, such as blood and urine. Among them, the more mainstream method is to measure by optical means, that is, to irradiate the above biological samples with light of a specific wavelength so that the specific biochemical substances in the above biological samples react with the above light, which may be absorption of the above light, so that the light intensity of the above light is weakened; or after absorbing the above light, another specific wavelength of light is stimulated (photoelectric colorimetry principle). By monitoring the changes in the light passing through the above biological samples, the content of the specific biochemical substances in the above biological samples can be determined.
[0003] However, the biochemical immunoassay analyzers in the prior art all adopt a single optical path design, that is, one instrument can only measure the data of one sample at a time. Today, people are more and more concerned about their own health. Faced with the increasing flow of people in hospitals, the efficiency of existing biochemical immunoassay analyzers is too low, and patients have to wait too long. To improve efficiency, the number of equipment must be increased, which brings additional costs to the hospital and takes up a lot of space. Therefore, how to find a way to improve the working efficiency of biochemical immunoassay analyzers is an urgent problem to be solved by technical personnel in this field. Summary of the invention
[0004] The purpose of the present invention is to provide a biochemical immunoassay analyzer to solve the problem of low working efficiency of biochemical immunoassay analyzers in the prior art.
[0005] In order to solve the above technical problems, the present invention provides a biochemical immunoassay analyzer, comprising a light source component, a spectroscopic component and a plurality of colorimetric components;
[0006] The light source assembly is used to provide the output light, and the output light is monochromatic light;
[0007] The light splitting component is used to split the output light into a plurality of identical outgoing lights, and each of the outgoing lights is respectively emitted into the corresponding colorimetric component;
[0008] The colorimetric component is used to receive the emitted light and collect the optical signal after the emitted light passes through the biological sample;
[0009] The output end of the light splitting component corresponds to the colorimetric component one by one.
[0010] Optionally, in the biochemical immunoassay analyzer, the spectroscopic component is a spectroscopic optical fiber.
[0011] Optionally, in the biochemical immunoassay analyzer, the light splitting optical fiber is a Y-type optical fiber.
[0012] Optionally, in the biochemical immunoassay analyzer, the light source assembly includes a light emitting module and a light filtering module;
[0013] The light emitting module is used to emit multi-color light;
[0014] The filter module is used to filter the polychromatic light to obtain the output light.
[0015] Optionally, in the biochemical immunoassay analyzer, the filter module is a filter wheel;
[0016] The filter wheel includes a plurality of filters corresponding to different wavelengths, and the different filters are aligned with the light outlet of the light emitting module by rotating the wheel.
[0017] Optionally, in the biochemical immunoassay analyzer, the colorimetric component is fixedly connected to the same positioning substrate.
[0018] Optionally, in the biochemical immunoassay analyzer, the drive motor of the filter wheel is a stepper motor.
[0019] Optionally, in the biochemical immunoassay analyzer, the light source assembly further includes a positioning light.
[0020] Optionally, in the biochemical immunoassay analyzer, the colorimetric component further includes a shielding cover;
[0021] The shielding cover is used to shield external electromagnetic signal interference.
[0022] Optionally, in the biochemical immunoassay analyzer, the light emitting device of the light source assembly is a halogen lamp.
[0023] The biochemical immunoassay analyzer provided by the present invention includes a light source component, a spectroscopic component and a plurality of colorimetric components; the light source component is used to provide the output light, and the output light is monochromatic light; the spectroscopic component is used to divide the output light into a plurality of identical outgoing light beams, and each of the outgoing light beams is respectively emitted into the corresponding colorimetric component; the colorimetric component is used to receive the outgoing light and collect the light signal after the outgoing light passes through the biological sample; the output end of the spectroscopic component corresponds one-to-one with the colorimetric component. The present invention divides the light emitted by the same light source component into a plurality of beams through the spectroscopic component and emits them into different colorimetric components, so that the biochemical immunoassay analyzer in the present invention can analyze biological samples in a plurality of colorimetric components at the same time, which greatly improves the working efficiency of the biochemical immunoassay analyzer compared with the biochemical immunoassay analyzer in the prior art that can only analyze one biological sample at the same time. BRIEF DESCRIPTION OF THE DRAWINGS
[0024] In order to more clearly illustrate the embodiments of the present invention or the technical solutions of the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.
[0025] Figure 1 A schematic diagram of a specific embodiment of the biochemical immunoassay analyzer provided by the present invention;
[0026] Figure 2 A schematic structural diagram of a specific implementation of the biochemical immunoassay analyzer provided by the present invention;
[0027] Figure 3 A schematic structural diagram of a spectroscopic component of another specific embodiment of the biochemical immunoassay analyzer provided by the present invention;
[0028] Figure 4 A schematic diagram of the explosion structure of the connection between the light emitting module and the filter module of another specific embodiment of the biochemical immunoassay analyzer provided by the present invention;
[0029] Figure 5 A schematic structural diagram of a light source assembly of another specific embodiment of a biochemical immunoassay analyzer provided by the present invention;
[0030] Figure 6 A schematic diagram of an explosion structure of a filter wheel according to another specific embodiment of the biochemical immunoassay analyzer provided by the present invention;
[0031] Figure 7 A schematic diagram of the exploded structure of a colorimetric component of a specific embodiment of the biochemical immunoassay analyzer provided by the present invention;
[0032] Figure 8 A schematic structural diagram of a refracting mirror mounting block of a specific embodiment of a biochemical immunoassay analyzer provided by the present invention;
[0033] Fig. 9 A schematic structural diagram of a light source refraction box of a specific implementation manner of a biochemical immunoassay analyzer provided by the present invention. DETAILED DESCRIPTION
[0034] In order to enable those skilled in the art to better understand the scheme of the present invention, the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.
[0035] The core of the present invention is to provide a biochemical immunoassay analyzer, a schematic diagram of a specific embodiment of which is shown in FIG. Figure 1 As shown, it is called the specific implementation mode 1, which includes a light source component 100, a light splitting component 200 and a plurality of colorimetric components 300;
[0036] The light source assembly 100 is used to provide the output light, and the output light is monochromatic light;
[0037] The light splitting component 200 is used to split the output light into multiple identical outgoing light beams, and each of the outgoing light beams is respectively emitted into the corresponding colorimetric component 300;
[0038] The colorimetric component 300 is used to receive the emitted light and collect the optical signal after the emitted light passes through the biological sample;
[0039] The output end of the light splitting component 200 corresponds to the colorimetric component 300 one by one.
[0040] The light splitting component 200 may be a light splitting optical fiber; the light splitting optical fiber has a certain degree of softness and toughness, which can make the optical path arrangement inside the biochemical immunoassay analyzer more free.
[0041] It is important to note that Figure 1 The portion framed by the dotted line indicates that all structures within the frame are the colorimetric component 300 , rather than all structures within the frame being collectively referred to as the colorimetric component 300 .
[0042] A structural schematic diagram of a specific embodiment of the biochemical immunoassay analyzer provided by the present invention is shown in FIG. Figure 2 As shown in the figure, the colorimetric component 300 is fixedly connected to the same positioning substrate 400; the biochemical immunoassay analyzer has very high requirements for the stability of the optical path, and any slight change in the amount of light or angle of the light incident on the colorimetric component 300 will affect the final measurement result. Therefore, the positioning substrate 400 is used to fix the colorimetric device, so that the colorimetric device will not be displaced due to external force, which can improve the stability and service life of the device.
[0043] The structural schematic diagram of a specific implementation of the colorimetric component 300 is as follows Figure 7 As shown, the installation process is: first install the refractor 330 into the refractor mounting block 320, and then tighten it with the plastic set screw 310, install the optical path shaper 340 and the sealing ring 350 into the light source refraction box 360, and then tighten it with the refractor mounting block 320, and install the signal acquisition PD370 located on the signal amplifier board 380 on the opposite side.
[0044] Figure 8It is a schematic structural diagram of the light source refraction box 360 from another angle, wherein the optical fiber connector 361 is used to connect the splitting optical fiber.
[0045] Fig. 9 It is a schematic structural diagram of the refractor mounting block 320 from another angle.
[0046] Furthermore, the colorimetric component 300 further includes a shielding cover 390; the shielding cover 390 is used to shield external electromagnetic signal interference, so that the detection result obtained by the colorimetric device is more accurate.
[0047] The biochemical immunoassay analyzer provided by the present invention includes a light source component 100, a spectroscopic component 200 and a plurality of colorimetric components 300; the light source component 100 is used to provide the output light, and the output light is monochromatic light; the spectroscopic component 200 is used to divide the output light into a plurality of identical outgoing lights, and each of the outgoing lights is respectively emitted into the corresponding colorimetric component 300; the colorimetric component 300 is used to receive the outgoing light and collect the optical signal after the outgoing light passes through the biological sample; the output end of the spectroscopic component 200 corresponds to the colorimetric component 300 one by one. The present invention divides the light emitted by the same light source component 100 into a plurality of beams through the spectroscopic component 200 and emits them into different colorimetric components 300, so that the biochemical immunoassay analyzer in the present invention can analyze biological samples in a plurality of colorimetric components 300 at the same time, which greatly improves the working efficiency of the biochemical immunoassay analyzer compared with the biochemical immunoassay analyzer in the prior art that can only analyze one biological sample at the same time.
[0048] On the basis of the first specific implementation, the above-mentioned light splitting component 200 is further improved to obtain the second specific implementation. The structural schematic diagram of the improved light splitting component 200 is as follows: Figure 3 As shown, it includes a light source component 100, a light splitting component 200 and a plurality of colorimetric components 300;
[0049] The light source assembly 100 is used to provide the output light, and the output light is monochromatic light;
[0050] The light splitting component 200 is used to split the output light into multiple identical outgoing light beams, and each of the outgoing light beams is respectively emitted into the corresponding colorimetric component 300;
[0051] The colorimetric component 300 is used to receive the emitted light and collect the optical signal after the emitted light passes through the biological sample;
[0052] The output end of the light splitting component 200 corresponds to the colorimetric component 300 one by one;
[0053] The light splitting optical fiber is a Y-type optical fiber.
[0054] Compared with the above-mentioned specific implementation, the difference of the present application is that the present specific implementation defines the above-mentioned light splitting component 200, and the remaining structures are the same as the above-mentioned specific implementation, which will not be elaborated here.
[0055] This specific implementation method defines the light splitting component 200 as a Y-type optical fiber, that is, there are two colorimetric devices corresponding to the two light output ports of the Y-type optical fiber respectively. To split a beam of light into multiple beams of light with almost the same properties, the more beams there are, the higher the process difficulty and the lower the stability. Therefore, this specific implementation method adopts a Y-type optical fiber that splits the output light into two, which not only improves the working efficiency of the biochemical immunoassay analyzer, but also improves the working stability of the biochemical immunoassay analyzer.
[0056] On the basis of the second specific implementation, the above light source assembly 100 is further improved to obtain a third specific implementation, the structural diagram of which is as follows: Figure 3 As shown, it includes a light source component 100, a light splitting component 200 and a plurality of colorimetric components 300;
[0057] The light source assembly 100 is used to provide the output light, and the output light is monochromatic light;
[0058] The light splitting component 200 is used to split the output light into multiple identical outgoing light beams, and each of the outgoing light beams is respectively emitted into the corresponding colorimetric component 300;
[0059] The colorimetric component 300 is used to receive the emitted light and collect the optical signal after the emitted light passes through the biological sample;
[0060] The output end of the light splitting component 200 corresponds to the colorimetric component 300 one by one;
[0061] The light splitting optical fiber is a Y-type optical fiber;
[0062] The light source assembly 100 includes a light emitting module 110 and a light filtering module 120;
[0063] The light emitting module 110 is used to emit multi-color light;
[0064] The filter module 120 is used to filter the polychromatic light to obtain the output light;
[0065] The filter module 120 is a filter wheel 123;
[0066] The filter wheel 123 includes a plurality of filters 1233 corresponding to different wavelengths. The filter wheels 1233 are rotated to align the light outlets of the light emitting modules 110 .
[0067] The difference between this specific embodiment and the above specific embodiment is that this specific embodiment further defines the composition and structure of the light source assembly 100, and the remaining structures are the same as those of the above specific embodiment, which will not be elaborated here.
[0068] Figure 4 Schematic diagram of the exploded structure of the connection between the light emitting module 110 and the filter module 120 in this specific embodiment, Figure 5 1 is a schematic diagram of the structure of the light source assembly 100, wherein the filter wheel 123 has a hole at the center, is equipped with a rotating shaft 124 of the filter wheel 123, a bearing 125 and a synchronous pulley 126, and is connected to a sliding optical fiber connection seat 115. The optical shaping device 112 and the fan 114 are also mounted on the sliding optical fiber connection seat 115 and pressed by a halogen lamp fixing frame 111. The halogen lamp 113 is installed into the sliding optical fiber connection seat 115 from the side. The stepper motor 121 is mounted on the bottom of the sliding optical fiber connection seat 115 and is connected to the filter wheel 123 by a synchronous belt 122. The positioning light 116 provides precise positioning for the filter wheel 123.
[0069] The structure explosion diagram of the filter wheel 123 is as follows Figure 6 As shown, it includes a filter wheel 1231, a wheel sealing ring 1232, a filter mirror 1233 and a filter wheel cover 1234.
[0070] In particular, the driving motor of the filter wheel 123 is a stepper motor 121; when the stepper motor 121 is not overloaded, the motor speed and stop position only depend on the frequency and pulse number of the pulse signal, and are not affected by load changes. Therefore, the position of the filter 1233 on the filter wheel 123 can be positioned more accurately, thereby improving working stability.
[0071] Furthermore, the light source assembly 100 also includes a positioning light 116 to further ensure the precise positioning of the filter 1233 .
[0072] It should be noted that the light emitting device of the light source assembly 100 is a halogen lamp 113 .
[0073] This specific implementation further defines the structure of the light source assembly 100 , and filters the polychromatic light emitted by the light emitting module 110 through the filter wheel 123 , thereby achieving rapid switching of the output light of different wavelengths, and further improving the working efficiency of the biochemical immunoassay analyzer.
[0074] In this specification, each embodiment is described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the embodiments can be referred to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part.
[0075] It should be noted that, in this specification, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "comprise", "include" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the statement "comprises a ..." does not exclude the presence of other identical elements in the process, method, article or device including the element.
[0076] The above is a detailed introduction to the biochemical immunoassay analyzer provided by the present invention. Specific examples are used herein to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only used to help understand the method of the present invention and its core idea. It should be pointed out that for ordinary technicians in this technical field, without departing from the principle of the present invention, the present invention can also be improved and modified, and these improvements and modifications also fall within the scope of protection of the claims of the present invention.
Claims
1. A biochemical immunoassay analyzer, characterized in that: It includes a light source component, a light splitting component and a plurality of colorimetric components; The light source assembly is used to provide output light, and the output light is monochromatic light; The light splitting component is used to split the output light into a plurality of identical outgoing lights, and each of the outgoing lights is respectively emitted into the corresponding colorimetric component; The colorimetric component is used to receive the emitted light and collect the optical signal after the emitted light passes through the biological sample; The output end of the light splitting component corresponds to the colorimetric component one by one; The light source assembly includes a light emitting module and a light filtering module; The light emitting module is used to emit multi-color light; The filter module is used to filter the polychromatic light to obtain the output light; The filter module is a filter wheel; The filter wheel includes a plurality of filters corresponding to different wavelengths, and the different filters are aligned with the light outlet of the light emitting module by rotating the wheel; The colorimetric component is fixedly connected to the same positioning substrate; The installation process of the colorimetric component includes: First install the refractor into the refractor mounting block, then tighten it with plastic set screws, install the optical path shaping device and the sealing ring into the light source refraction box, and then tighten it with the refractor mounting block, and install the signal acquisition PD located on the signal amplifier board on the opposite side.
2. The biochemical immunoassay analyzer according to claim 1, characterized in that: The light splitting component is a light splitting optical fiber.
3. The biochemical immunoassay analyzer according to claim 2, characterized in that: The light splitting optical fiber is a Y-type optical fiber.
4. The biochemical immunoassay analyzer according to claim 1, characterized in that: The driving motor of the filter wheel is a stepping motor.
5. The biochemical immunoassay analyzer according to claim 4, characterized in that: The light source assembly also includes a positioning light.
6. The biochemical immunoassay analyzer according to claim 5, characterized in that: The colorimetric component also includes a shielding cover; The shielding cover is used to shield external electromagnetic signal interference.
7. The biochemical immunoassay analyzer according to claim 6, characterized in that: The light emitting device of the light source assembly is a halogen lamp.
Citation Information
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