A 3D printed bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex

Abstract

The present invention discloses a 3D printed bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex, including: an upper end plate, a lower end plate, a bionic vertebral body and an anti-dislocation structure, the bionic vertebral body includes a vertebral body body hollowed out in the middle, an upper acetabulum is arranged on the upper part of the vertebral body body, and a lower acetabulum is arranged on the lower part; the upper acetabulum is connected to the upper end plate through an upper end plate joint structure, and the lower part is connected to the lower end plate through a lower joint structure; the present invention has sufficient support structure, and can provide stable support after anterior cervical vertebral resection; the present invention replaces the movement function of the normal cervical vertebra through the movement of its own ball joint, can retain the original range of motion of the cervical vertebra, and prevent the occurrence of adjacent segment diseases of the cervical vertebra caused by fusion surgery, and the present invention has a matching anti-dislocation structure, which is placed in the occurrence of dislocation during joint activity. The implantation operation of the present invention is less difficult, less traumatic, and easy to promote.

Description

[Technical field]

[0001] The invention relates to a 3D printed bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex. [Background technology]

[0002] With the progress of the times and the change of work forms, the number of people who work at desks for long periods of time is increasing year by year, and the trend of population aging is gradually aggravating. Therefore, the incidence of cervical spine diseases (such as cervical spondylosis, vertebral tumors, etc.) is increasing year by year. The focus of surgical treatment of cervical spine diseases is to relieve compression and simultaneously rebuild the stability of the spine. The surgery needs to remove the pathological factors that cause compression of the spinal cord and nerve roots, and implant different types of spinal implants to obtain immediate stability and maintain it for a long time. At present, subtotal cervical vertebral decompression combined with vertebral fusion is one of the important methods for treating cervical spine diseases. This procedure reaches the vertebral body and intervertebral disc through the anterior cervical approach, uses a vertebral body spreader to spread the adjacent upper and lower vertebrae of the target vertebra, removes the diseased intervertebral disc, subtotally removes most of the vertebral bodies and posterior longitudinal ligaments in the bilateral uncovertebral joints, implants suitable spinal implants in the defect area, and uses an anterior cervical plate for fixation. Titanium cage, as a kind of fusion-type artificial vertebra, has sufficient support strength and good biocompatibility, and is one of the commonly used implants in cervical fusion. A large number of literature reports have shown that subtotal cervical corpectomy and decompression combined with titanium cage bone graft fusion can achieve good clinical results for relevant patients (Moreland DB, Asch HL, Clabeaux DE, et al. Anterior cervical discectomy and fusion with implantable titanium cage: initial impressions, patient outcomes and comparison to fusion with allograft. The spine journal: official journal of the North American Spine Society. 2004; 4(2): 184-191; discussion 191).

[0003] In 1969, Hamdi first reported the treatment of a patient with plasmacytoma and a patient with metastatic adenocarcinoma by using an artificial vertebra instead of an excised vertebra (Hamdi, FA. Prosthesis for an excised lumbar vertebra: apreliminary report. Can Med Assoc J, 1969, 100, 12: 576-80.). Since then, scholars from various countries have conducted extensive research on artificial vertebrae. Artificial vertebrae are mainly divided into fusion-type artificial vertebrae and movable-type artificial vertebrae. Fusion-type artificial spinal implants are currently commonly used in clinical practice. They have the advantages of good mechanical properties and strong immediate stability, such as 3D printed titanium cage for the lower cervical spine (He Xijing, Lu Teng, Dong Jun, et al. A 3D printed titanium cage for the lower cervical spine [P]. China, CN204931903U, 2016-01-06), Winged adjustable replacement system (Sun Junkai, Liu Jinglong, Huang Jianhou. Application of winged adjustable replacement system in fracture and dislocation of the lower cervical spine (English) [J]. Chinese Journal of Tissue Engineering Research, 2013, 17(22): 4025-4033.), etc.However, studies have found that after implantation of fusion-type artificial vertebral bodies, the original normal physiological range of motion of the spine is lost, the stress in the adjacent intervertebral disc increases, and the range of motion between adjacent vertebrae increases (Dmitriev AE, Cunningham BW, Hu NB, et al. Adjacent level intradiscal pressure and segmental kinematics following acervical total disc arthroplasty-An In Vitro human cadaveric model. Spine. 2005; 30(10): 1165-1172), (Hilibrand AS, Carlson GD, Palumbo MA, et al. Radiculopathy and myelopathy at segments adjacent to the site of a previous anterior cervical arthrodesis. J Bone Joint Surg-Am Vol. 1999; 81A(4): 519-528.), which may cause degeneration of the adjacent intervertebral disc and vertebral bone hyperplasia in the long run (Phillips FM, Reuben J, Wetzel ft. Intervertebral disc degeneration adjacent to a lumbar fusion. Anexperimental rabbit model [J]. J Bone Joint Surg Br, 2002, 84(2): 289-294.) (Hilibrand AS, Robbins M. Adjacent segment degeneration and adjacent segment disease: the consequences of spinal fusion? The spine journal: official journal of the North American Spine Society. 2004; 4 (6 Suppl): 190S-194S).A study found that after a two-year follow-up study, some scholars found that compared with fusion surgery, maintaining cervical spine movement can effectively prevent symptomatic changes in adjacent vertebrae and reduce changes in adjacent vertebral imaging indicators (Robertson JT, Papadopoulos SM, Traynelis VC. Assessment of adjacent-segment disease in patients treated with cervical fusion or arthroplasty: a prospective 2-year study. Journal of Neurosurgery-Spine. 2005; 3(6): 417-423).

[0004] In order to preserve the original physiological mobility of the spine and reduce the possibility of adjacent intervertebral diseases, the concept of non-fusion and mobility has gradually become the mainstream. Non-fusion surgery, such as artificial disc replacement, only removes the diseased intervertebral disc and replaces it with an artificial disc, which is a typical representative of non-fusion surgery. However, artificial disc replacement has a narrow scope of application and is only suitable for the treatment of diseases with single segment and physiological curvature of the cervical spine. It is not suitable for the presence of vertebral lesions and multi-stage lesions (Sekhon LH. Cervical arthroplasty in the management of spondylotic myelopathy [J]. J Spinal Disord Tech, 2003, 16 (4): 307-313). In order to solve the problems existing in non-fusion surgery, movable artificial vertebrae have become a hot topic of research. Currently, common movable artificial vertebrae include artificial disc and vertebra system (Dong, J, LU M, LU T, et al. Artificial disc and vertebra system: novel motion preservation device for cervical spinal disease after vertebral corpectomy [J]. CLINICS, 2015, 70 (7): 493-499.), artificial cervical joint complex (YU J, LIU LT, ZHAO JN. Design and preliminary biomechanical analysis of artificial cervical joint complex [J]. Arch Orthop Trauma Surg, 2013, 133 (6): 735-743.). However, these movable artificial vertebrae still have the following problems, such as insufficient protection of the movable joint surface, which may cause the risk of joint dislocation; too little contact surface between the artificial vertebrae and the bone in the structural design, which is not conducive to the growth of bone cells; the fixed part of the artificial vertebrae exceeds the range of the vertebrae, which may cause compression and damage to local tissues and organs.

[0005] 3D printing is a processing technology that uses computer-aided design, digital models as the basis, and models are layered and printed and integrated through laser sintering, light curing, etc. The advantages of 3D printing technology are that it can process complex structures and can personalize the appearance and structure. At the same time, it can save costs and improve production efficiency. It has a broad development space in the field of orthopedics (Bose S, Vahabzadeh S, Bandyopadhyay A. Bone tissue engineering using 3D printing. Mater Today. 2013; 16(12): 496-504. Therefore, applying 3D printing to the design and manufacture of spinal implants can not only customize suitable implants according to patient information, but also greatly promote the performance improvement and innovation of implants. [Summary of the invention]

[0006] The purpose of the present invention is to solve the problems in the prior art and provide a 3D printed bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex. The bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex is designed based on human body data, has sufficient supporting function, can retain normal cervical spine mobility, has an anti-dislocation structure, can provide sufficient bone grafting space and bone contact surface, achieve immediate stability after surgery, and can also achieve immediate motor function reconstruction after anterior cervical surgery, so that its activity performance is highly bionic with that of a normal cervical spine, and this stability and motor function can be maintained for a long time.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions:

[0008] A 3D printed bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex, comprising:

[0009] An upper end plate, the bottom of which is connected to the bionic vertebral body via an upper end plate joint structure;

[0010] A lower end plate, the top of which is connected to the bionic vertebral body via a lower end plate joint structure;

[0011] A bionic vertebral body, the bionic vertebral body comprising a vertebral body body with a hollow middle portion, an upper mortise is provided at the upper portion of the vertebral body body, and a lower mortise is provided at the lower portion; the upper mortise is connected to the upper end plate via an upper end plate joint structure, and the lower portion is connected to the lower end plate via a lower joint structure; a plurality of diamond-shaped through holes are provided on the front and back of the vertebral body body, and bone grafting windows are provided on both sides;

[0012] The anti-dislocation structure comprises an upper limit tooth and a lower limit tooth respectively arranged on the upper joint mortar and the lower joint mortar, and a plurality of first and second clamping grooves respectively arranged on the upper end plate joint structure and the lower end plate joint structure, the number and position of which correspond to the upper limit tooth and the lower limit tooth; the upper limit teeth are evenly spaced and distributed on the upper end surface of the upper joint mortar, and the lower limit teeth are evenly spaced and distributed on the lower end surface of the lower joint mortar;

[0013] The upper end plate, the lower end plate and the bionic vertebral body are all made by 3D printing.

[0014] The present invention is further improved in that:

[0015] The upper end plate includes a first platform, and a pair of first nail channels with parallel axes and symmetrical divisions are provided in the front section of the first platform. The axes of the two first nail channels are arranged at an angle with the plane of the first platform to facilitate the fixation of screws; an arc-shaped support structure is arranged on the upper surface of the first platform.

[0016] The two first nail channels are opened in the front structure area of ​​the first platform, the support structure is arranged in the rear structure area of ​​the first platform, and the highest point of the arc of the support structure is located at the rear of the first platform, and the arc surface height decreases smoothly around.

[0017] The lower end plate includes a second platform, and the front section of the second platform is provided with two pairs of second nail channels with parallel axes and symmetrical divisions. The axes of the two second nail channels are arranged at an angle with the plane of the second platform to facilitate the fixation of screws.

[0018] The two second nail channels are opened in the front structure area of ​​the second platform.

[0019] The upper end plate joint structure comprises a first joint ball handle, the top of the first joint ball handle is fixedly connected to the lower surface of the upper end plate, and the bottom is provided with a first joint ball, and the first joint ball is installed in the upper joint socket;

[0020] The lower end plate joint structure comprises a second joint ball handle, the bottom of the second joint ball handle is fixedly connected to the upper surface of the lower end plate, and a second joint ball is arranged on the top, and the second joint ball is installed in the lower joint socket.

[0021] The upper limit tooth is arranged at the top of the upper acetabulum, and the lower limit tooth is arranged at the bottom of the lower acetabulum. The free ends of the upper limit tooth and the lower limit tooth both point to the center of the acetabulum; the first slots are evenly spaced on the first joint ball, and the second slots are evenly spaced on the second joint ball.

[0022] A support column is arranged inside the vertebral body. The support column is a beveled cylinder, the upper surface of which is connected to the bottom end of the upper acetabulum and extends smoothly around, and the lower surface is connected to the top end of the lower acetabulum and extends smoothly around.

[0023] The front side of the vertebral body is provided with four layers of diamond-shaped through holes, with three holes arranged in a staggered manner in each layer; the back side is provided with three layers, with three holes arranged in a staggered manner in each layer.

[0024] Compared with the prior art, the present invention has the following beneficial effects:

[0025] The present invention has sufficient support structure, which can provide stable support after anterior cervical vertebrae resection; the present invention replaces the movement function of the normal cervical spine through the movement of its own ball joint, which can retain the original range of motion of the cervical spine and prevent the occurrence of adjacent segment diseases of the cervical spine caused by fusion surgery, and the present invention has a matching anti-dislocation structure to prevent the occurrence of dislocation during joint movement. In addition, the present invention has a bone grafting window and a bone grafting space, which can accelerate biological fusion and maintain long-term stability through intraoperative bone grafting. The implantation surgery of the present invention is less difficult, less traumatic, and easy to promote. The use of 3D printing for personalized customization can reduce the burden of production and carrying, and can provide suitable implants.

[0026] Furthermore, the upper surface support structure of the upper end plate of the present invention is designed to be arc-shaped according to human body information data, which conforms to the concave shape of the surface of the lower end plate of the human cervical spine, increases the contact area between the upper end plate and the lower surface of the upper vertebral body, reduces the pressure on the lower side of the cervical vertebrae, and enhances stability.

[0027] Furthermore, the present invention relies on the nail channels in the upper and lower end plate platform structures to be self-fixed on the adjacent vertebral bodies without the assistance of anterior steel plates; and the nail channels are located in the artificial vertebral body structure, and after fixation, no local space occupation is caused and the functions of adjacent organs (such as the esophagus, trachea, etc.) are not affected.

[0028] Furthermore, the present invention provides a slot on the surface of the upper and lower joint balls, which matches the anti-dislocation structure of the top of the upper and lower joint sockets of the vertebral body components. When the upper and lower end plates are installed into the joint sockets along the slots and the end plates are rotated to a suitable position, the anti-dislocation structure will prevent the joint ball from falling out.

[0029] Furthermore, in the present invention, bone grafting windows are provided on both sides of the vertebral body component, and the center is hollowed out to provide space for surgical bone grafting, which is beneficial to improving fusion.

[0030] Furthermore, a load-bearing column is provided in the middle of the vertebral body component of the present invention, which can improve the overall mechanical properties, provide sufficient stability, reduce the amount of surrounding materials, and further increase the internal bone grafting space.

[0031] Furthermore, a load-bearing column is provided in the middle of the vertebral body component of the present invention, which is inclined by 10° from front to back, conforming to the intervertebral angle of the human cervical spine and facilitating the maintenance of a normal physiological structure.

Brief Description of the Drawings

[0032] Figure 1It is an isometric schematic diagram of the overall structure of the present invention;

[0033] Figure 2 is a schematic structural diagram of the upper end plate of the present invention;

[0034] Figure 3 yes Figure 2 A front view of

[0035] Figure 4 yes Figure 2 Side view of

[0036] Figure 5 yes Figure 2 Bottom view of

[0037] Figure 6 is a side view of the lower end plate of the present invention;

[0038] Figure 7 is a front view of a vertebral body component of the present invention;

[0039] Figure 8 is a side view of a vertebral body component of the present invention;

[0040] Fig. 9 is a top view of a vertebral body component of the present invention;

[0041] Fig.10 It is a side half-section view of the overall structure of the present invention;

[0042] Fig.11 It is a side view of the overall structure of the present invention;

[0043] Fig.12 It is a top view of the overall structure of the present invention.

[0044] Among them: 1-upper end plate; 2-bionic vertebral body; 3-lower end plate; 4-first platform; 5-support structure; 6-first screw channel; 7-first joint ball handle; 8-first joint ball; 9-first slot; 10-upper joint socket; 11-upper limit tooth; 12-vertebral body; 13-support column; 14-bone grafting window; 15-lower joint socket; 16-lower limit tooth; 17-second slot; 18-second platform; 19-second screw channel; 20-second joint ball handle; 21-second joint ball. [Specific implementation method]

[0045] In order to enable those skilled in the art to better understand the scheme of the present invention, the technical scheme in the embodiment of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiment of the present invention. Obviously, the described embodiment is only an embodiment of a part of the present invention, not all embodiments, and is not intended to limit the scope of the present invention. In addition, in the following description, the description of well-known structures and technologies is omitted to avoid unnecessary confusion of the concepts disclosed in the present invention. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work should fall within the scope of protection of the present invention.

[0046] Various structural schematic diagrams of the embodiments disclosed in the present invention are shown in the accompanying drawings. These figures are not drawn to scale, and some details are magnified and some details may be omitted for the purpose of clear expression. The shapes of various regions and layers shown in the figures and the relative sizes and positional relationships therebetween are only exemplary, and may deviate in practice due to manufacturing tolerances or technical limitations, and those skilled in the art may additionally design regions / layers with different shapes, sizes, and relative positions according to actual needs.

[0047] In the context of the present disclosure, when a layer / element is referred to as being "on" another layer / element, the layer / element may be directly on the other layer / element, or an intervening layer / element may exist between them. In addition, if a layer / element is "on" another layer / element in one orientation, the layer / element may be "under" the other layer / element when the orientation is reversed.

[0048] It should be noted that the terms "first", "second", etc. in the specification and claims of the present invention and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the data used in this way can be interchanged where appropriate, so that the embodiments of the present invention described herein can be implemented in an order other than those illustrated or described herein. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device that includes a series of steps or units is not necessarily limited to those steps or units that are clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0049] The present invention is further described in detail below in conjunction with the accompanying drawings:

[0050] See also Figure 1The 3D printed bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex of the present invention comprises an upper end plate 1, a lower end plate 3, a bionic vertebral body 2 and an anti-dislocation structure. The upper end plate 1, the lower end plate 3 and the bionic vertebral body 2 are all made by 3D printing.

[0051] The bottom of the upper end plate 1 is connected to the bionic vertebra 2 through the upper end plate joint structure; the upper end plate 1 includes a first platform 4, and a pair of first screw channels 6 with parallel and symmetrical axes are provided in the front section of the first platform 4. The axes of the two first screw channels 6 are set at an angle with the plane of the first platform 4 to facilitate the fixation of screws; the upper surface of the first platform 4 is provided with an arc-shaped support structure 5. The two first screw channels 6 are opened in the front section of the first platform 4. The support structure 5 is arranged behind the first platform 4. The highest point of the arc of the supporting structure 5 is located at the rear of the first platform 4. The arc surface height decreases smoothly around. The upper end plate joint structure includes a first joint ball handle 7, the top of the first joint ball handle 7 is fixedly connected to the lower surface of the upper end plate 1, and a first joint ball 8 is arranged at the bottom, and the first joint ball 8 is installed in the upper joint socket 10;

[0052] The top of the lower end plate 3 is connected to the bionic vertebral body 2 through the lower end plate joint structure; the lower end plate 3 includes a second platform 18, and the front section of the second platform 18 is provided with two pairs of second screw channels 19 with parallel axes and symmetrical divisions. The axes of the two second screw channels 19 and the plane of the second platform 18 are set at an angle to facilitate the fixation of screws. The two second screw channels 19 are opened at the front of the second platform 18. The lower end plate joint structure includes a second joint ball handle 20 , the bottom of which is fixedly connected to the upper surface of the lower end plate 3 , and a second joint ball 21 is arranged on the top, and the second joint ball 21 is installed in the lower joint socket 10 .

[0053] The bionic vertebral body 2 includes a vertebral body 12, an upper acetabulum 10 is arranged on the upper part of the vertebral body 12, and a lower acetabulum 15 is arranged on the lower part; the upper acetabulum 10 is connected to the upper end plate 1 through an upper end plate joint structure, and the lower part is connected to the lower end plate 3 through a lower joint structure; a plurality of diamond-shaped through holes are provided on the front and back of the vertebral body 12, and a bone grafting window 14 is provided on the side; a support column 13 is provided in the vertebral body 12, and the support column 13 is a beveled cylinder, the upper surface of which is connected to the bottom end of the upper acetabulum 10 and extends smoothly to the surroundings, and the lower surface is connected to the top end of the lower acetabulum 15 and extends smoothly to the surroundings.

[0054] The anti-dislocation structure includes an upper limit tooth 11 and a lower limit tooth 16 respectively arranged on the upper mortabulum 10 and the lower mortabulum 15, and a first slot 9 and a second slot 17 respectively opened on the upper end plate joint structure and the lower end plate joint structure, and the number and position of the first limit tooth 11 and the lower limit tooth 16 correspond to the upper limit tooth 11 and the lower limit tooth 16; the upper limit tooth 11 and the lower limit tooth 16 are evenly spaced and distributed on the upper end surface of the mortabulum; the upper limit tooth 11 is arranged at the top of the upper mortabulum 10, and the lower limit tooth 16 is arranged at the bottom of the lower mortabulum 15, and the free ends of the upper limit tooth 11 and the lower limit tooth 16 both point to the center of the mortabulum; the first slots 9 are evenly spaced and opened on the first joint ball 8, and the second slots 17 are evenly spaced and opened on the second joint ball 21.

[0055] The structural principle of the present invention is as follows:

[0056] The 3D printed bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex of the present invention is mainly composed of three parts: a bionic vertebral body 2, and an upper end plate 1 and a lower end plate 3 respectively connected to the bionic vertebral body 2 through a joint ball structure. The bionic vertebral body 2 is composed of an upper joint socket 10, a vertebral body 12, a lower joint socket 15, and a support column 13; the upper joint socket 10 and the lower joint socket 15 both include an anti-dislocation structure; the vertebral body 12 includes a side bone grafting window 14; the upper end plate 1 and the lower end plate 3 are both composed of a platform, a joint ball handle and a joint ball; the first platform package 4 includes a support structure 5 and a pair of first nail channels 6; the joint ball structures of the upper end plate and the lower end plate both include a slot opened on their surfaces.

[0057] The upper end plate 1 constitutes the upper surface of the 3D printed bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex of the present invention. The two screw channels are symmetrically located in the front 1 / 4 structural area of ​​the first platform 4, and the axis is at a certain angle to the plane of the first platform to allow screw fixation; the upper end support structure 5 is located on the upper surface of the rear 3 / 4 structural area of ​​the first platform 4, in an arc shape, with the highest point located at the rear 4 / 7 of the first platform 4, and gradually decreases to the front and back and both sides.

[0058] The upper end plate joint structure is composed of a cylinder, which is connected to the center of the rear 3 / 4 structural area of ​​the lower surface of the first platform 4. The upper end plate joint structure includes a first joint ball 8 and three first slots 9, the upper surface of the first joint ball 8 is connected to the center of the lower surface of the first joint ball handle 7; the three first slots 9 are all rectangular parallelepiped groove structures, which are evenly spaced on the surface of the first joint ball 8.

[0059] The bionic vertebral body 2 includes a vertebral body 12, an upper joint mortise 10 is arranged on the top of the vertebral body 12, and three upper limit teeth 11 are arranged on the upper joint mortise 10, and the three upper limit teeth 11 are evenly spaced and distributed on the upper end table of the upper joint mortise 10, and together with three first slots 9, they form an upper anti-dislocation structure; the upper joint mortise 10 is composed of an arc surface, and the upper surface is a horizontal surface. A lower joint mortise 15 is arranged on the bottom of the vertebral body 12, and three lower limit teeth 16 are arranged on the lower joint mortise 15, and the three lower limit teeth 16 are evenly spaced and distributed on the lower end table of the lower joint mortise 15, and together with three second slots 17, they form a lower anti-dislocation structure; the lower joint mortise 15 is composed of an arc surface, and the lower surface is a horizontal surface.

[0060] The front of the vertebral body 12 is composed of 4 layers of staggered rhombus structures, with 3 rhombuses in each layer; the back is composed of 3 layers of staggered rhombus structures, with 3 rhombuses in each layer; the side is a bone grafting window 14; the vertebral body 12 is connected to the upper acetabulum upward.

[0061] A support column 13 is disposed inside the vertebral body 12. The support column 13 is composed of an inclined cylinder, the upper surface of which is connected to the lowest end of the upper acetabulum 10 and extends to the periphery, and the lower surface is connected to the top end of the lower acetabulum 15 and extends to the periphery.

[0062] The lower end plate 3 constitutes the lower side of the 3D printed bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex of the present invention. The two screw channels are symmetrically located in the front 1 / 4 structural area of ​​the second platform 18, and the axis is at a certain angle to the plane of the second platform 18, allowing screw fixation.

[0063] The lower end plate joint structure is composed of a cylinder, which is connected to the center of the rear 3 / 4 structural area on the upper surface of the second platform 18. The lower end plate joint structure includes a second joint ball 21 and three second slots 17, the lower surface of the second joint ball 21 is connected to the center of the lower surface of the second joint ball handle 20; the three second slots 17 are all rectangular parallelepiped groove structures, which are evenly spaced on the surface of the second joint ball 21.

[0064] The joint ball structure of the present invention includes the joint ball structure of the upper and lower end plates and the upper and lower joint sockets adapted to the joint balls at the upper and lower ends of the bionic vertebra 2. The internal space of the joint socket is composed of hemispherical spaces intersecting on both sides. The upper and lower limit teeth of the anti-dislocation structure are respectively arranged at the top and bottom of the hemispherical space. The first and second joint balls are wrapped in the corresponding hemispherical spaces, and their dislocation is limited by the cooperation between the groove on the surface of the joint ball and the limit teeth.

[0065] Example:

[0066] See also Figure 1 , 10, 11 and 12, in this embodiment, the front edge height of the 3D printed bionic anti-dislocation cervical movable artificial vertebra is 23mm, the rear edge height is 21mm, the vertical maximum height along the support structure 5 is 25mm, the highest point on the top is located at the back 3 / 7, gradually decreases toward both sides, and the lowest point on the bottom is located at the front. The anterior-posterior diameter is 15mm, and the left-right diameter is 13mm.

[0067] like Figure 2 , 3 As shown in , 4, 5 and 10, in this embodiment, the first platform 4 is 2mm high, with a front-to-back length of 15mm and a width of 13mm; the support structure 5 is located above and behind the first platform 4, in an arc shape, with the highest point located at the back 4 / 7, a height of 1.3mm, and gradually decreases toward the front and back and both sides; the two first nail channels 6 are cylindrical with a diameter of 3mm, symmetrically located in the front 1 / 4 structural area of ​​the first platform 4, with the axis forming an angle of 40° with the plane, allowing screw fixation. The first joint ball handle 7 is a cylinder with a diameter of 7mm and a height of 3mm, connected to the back 3 / 4 structural area of ​​the lower surface of the first platform 4. The first joint ball 8 has a round surface diameter of 9mm and a height of 2.5mm, connected to the lower surface of the first joint ball handle 7. The three first slots 9 are rectangular groove structures with a length of 1mm, a width of 0.75mm, and a height of 2.5mm, and are distributed on the surface of the first joint ball 8 at intervals of 60°. The purpose of the support structure 5 is to fit with the curved surface of the lower end plate of the upper vertebra, increase the contact area, and reduce the pressure on the lower side of the cervical vertebra, thereby effectively preventing bone destruction. The first nail channel 6 is opened on the first platform 4 of the upper end plate 1, which is a self-fixing method, does not require additional steel plate fixation, and reduces damage to surrounding tissues. The first slot 9 is compatible with the anti-dislocation structure and is a combined installation channel for the upper end plate 1 and the bionic vertebra 2.

[0068] like Figure 2 , 3 As shown in Figures 4, 5, 6 and 10, in this embodiment, the second platform 18 is 2mm high, 15mm long from front to back and 13mm wide; the two second nail channels 19 are cylindrical with a diameter of 3mm, symmetrically located in the front 1 / 4 structural area of ​​the second platform 18, and the axis is at a 40° angle with the plane, allowing screw fixation. The second joint ball handle 20 is a cylinder with a diameter of 7mm and a height of 3mm, which is connected to the posterior 3 / 4 structural area on the upper surface of the second platform 18. The second joint ball 21 has a circular surface diameter of 9mm and a height of 2.5mm, and is connected to the upper surface of the second joint ball handle 20. The three second slots 17 are all rectangular groove structures with a length of 0.75mm, a width of 0.5mm, and a height of 2.5mm, and are distributed on the surface of the second joint ball 21 at intervals of 60°. The second nail channel 19 is located inside the second platform 18 of the upper end plate 1, which is a self-fixing method. It does not require additional steel plate fixation, thereby reducing damage to surrounding tissues. The second slot 17 is adapted to the anti-dislocation structure and is a combined installation channel for the lower end plate 3 and the bionic vertebral body 2 .

[0069] like Figure 2 , 6 As shown in , 7, 8, 9 and 10, in this embodiment, the upper acetabulum 10 and the lower acetabulum 15 are both composed of the same arc surface as the joint ball, with a thickness of 1mm and a horizontal top. The anti-dislocation structure is composed of 3 cubes with a side length of 1mm, which are distributed at the upper end table of the acetabulum arc surface at a spacing of 60°, and are 1mm away from the joint ball. The vertebral body 12 has a front edge height of 15mm, a rear edge height of 12mm, a front-to-back length of 9mm, and a left-right width of 10mm. The front is composed of 4 layers of staggered rhombus structures, with 3 rhombuses in each layer; the back is composed of 3 layers of staggered rhombus structures, with 3 rhombuses in each layer; and there is a bone grafting window 14 on each side. The anti-dislocation structure is compatible with the first slot 9, and after installation, it prevents the upper end plate 1 and the lower end plate 3 from falling out of the corresponding acetabulum. The vertebral body 12 is a hollow design, which increases the contact area between the implanted bone particles and the surrounding bone, which is conducive to the early fusion of the bone in the surgical area and improves the long-term stability. The bone graft window 14 has a large aperture, which is convenient for bone grafting during surgery. The support column 13 is a 4mm diameter inclined cylinder, which is respectively connected to the top arc surface of the upper joint socket 10 and the bottom arc surface of the lower joint socket 15. The vertebral body 12 and the support column 13 can be adjusted according to different individual imaging data.

[0070] like Figure 2 , 3 , 4, 5, 6, 9 and 10, the first joint mortise 10 and the second joint mortise 15 have a large internal space, which can accommodate and enable the first joint ball 8 and the second joint ball 21 to move. Taking the upper end plate 1 as an example, when installing, align the first slot 9 with the upper limit tooth 11 on the first joint mortise 10, install it along the first slot 9, and rotate the upper end plate 1 by 60° to reach the required standard position, such as Figure 1 The first joint ball 8 is wrapped in the second joint socket 10 and is restricted by the anti-dislocation structure to prevent the artificial vertebral end plate from falling out and to reserve sufficient space for movement. The installation process of the lower end plate 3 is the same as that of the upper end plate 1.

[0071] Because the height of the cervical spine varies among people, 5 different models are designed based on imaging data to meet different implant height requirements. There are 5 models: the largest, large, standard, small, and smallest. The standard model is the above embodiment, and the largest size is based on the standard model, with the vertebral body 12 and the support column 13 lengthened by 2mm. The large size is based on the standard model, with the vertebral body 12 and the support column 13 lengthened by 1mm. The small size is based on the standard model, with the vertebral body 12 and the support column 13 reduced by 1mm. The smallest size is based on the standard model, with the vertebral body 12 and the support column 13 reduced by 2mm.

[0072] In summary, the 3D printed bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex of the present invention is suitable for diseases that require subtotal cervical corpectomy decompression combined with implant fusion, and is particularly suitable for cervical diseases with two gaps in a single vertebra, such as cervical spondylosis caused by two-segment cervical disc herniation, single cervical vertebra tumors, and revision after artificial cervical disc replacement surgery.

[0073] The following is a description of the specific implementation methods of intervertebral disc removal, subtotal corpectomy, the present movable artificial cervical vertebra and intervertebral connection complex implantation:

[0074] For patients with indications, complete preoperative examinations. For patients without contraindications, perform preoperative exercises such as defecation and urination in bed before the surgery. The patient is in a supine position, with soft pillows under the shoulders, a soft head circle behind the head, and small sandbags on both sides of the head. Routine preoperative preparation, endotracheal intubation and general anesthesia, disinfection and draping of the neck area. An anterior cervical transverse incision is used to separate the soft tissue layer by layer, and the trachea and esophagus are protected by retractors. The target vertebral area is exposed, the positioning pin is installed, and the C-arm X-ray fluoroscopy machine is used to locate and confirm the target vertebra. Cervical vertebral body distractor screws are installed in the upper and lower vertebrae of the target vertebra, and the distractor is distracted. The intervertebral disc fiber ring above and below the target vertebra is cut, and the intervertebral disc tissue is removed using a nucleus pulposus forceps. The anterior vertebral bone is removed using a rongeur, and the intervertebral articular surface is repaired with a curette, a rongeur, and a round-head file, but the bony endplate should not be damaged. Use a nerve dissector to separate the gap between the posterior edge of the vertebral body and the posterior longitudinal ligament, and use a bone rongeur to remove the cortical bone and ossified posterior longitudinal ligament of the posterior edge of the vertebral body. Slot decompression to form a rectangular decompression groove with a width of approximately 13 mm. Select a complex of appropriate height, cut the vertebral bone into pieces of about 2 mm in size, and fill the internal hollow structure from the bone graft windows on both sides of the artificial vertebral body. Install the upper and lower end plates, and adjust the angle to prevent them from falling out. Insert the complex so that the upper end plate fits the lower end plate of the upper vertebral body, and the lower end plate fits the upper end plate of the lower vertebral body. Screw in 2 vertebral fixation screws on each side to fix the complex. Loosen the vertebral body spreader to make the complex fit tightly. Use C-arm X-ray fluoroscopy to confirm the position of the implant, rinse the wound with saline, place drainage, and suture layer by layer. Routine postoperative care, remove the drainage after 1 day, and immobilize the cervical collar for 3 months.

[0075] The above contents are only for explaining the technical idea of ​​the present invention and cannot be used to limit the protection scope of the present invention. Any changes made on the basis of the technical solution in accordance with the technical idea proposed by the present invention shall fall within the protection scope of the claims of the present invention.

Claims

1. A 3D printed bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex, characterized in that: include: An upper end plate (1), the bottom of which is connected to the bionic vertebra (2) via an upper end plate joint structure; the upper end plate (1) comprises a first platform (4), the front section of which is provided with a pair of first screw channels (6) with parallel axes and symmetrically divided, the axes of the two first screw channels (6) being arranged at an angle with the plane of the first platform (4) for convenient screw fixation; an arc-shaped support structure (5) is arranged on the upper surface of the first platform (4); the upper end plate joint structure comprises a first joint ball handle (7), the top of which is fixedly connected to the lower surface of the upper end plate (1), a first joint ball (8) is arranged at the bottom, and the first joint ball (8) is installed in the upper joint socket (10); the lower end plate joint structure comprises a second joint ball handle (20), the bottom of which is fixedly connected to the upper surface of the lower end plate (3), a second joint ball (21) is arranged at the top, and the second joint ball (21) is installed in the lower joint socket (10); A lower end plate (3), the top of the lower end plate (3) being connected to the bionic vertebral body (2) via a lower end plate joint structure; A bionic vertebral body (2), the bionic vertebral body (2) comprising a vertebral body (12) with a hollowed-out middle portion, an upper joint socket (10) being arranged at the upper portion of the vertebral body (12), and a lower joint socket (15) being arranged at the lower portion; the upper joint socket (10) being connected to the upper end plate (1) via an upper end plate joint structure, and the lower portion being connected to the lower end plate (3) via a lower joint structure; a plurality of rhombus-shaped through holes being arranged at the front and back of the vertebral body (12), and bone grafting windows (14) being arranged at both side surfaces; The anti-dislocation structure comprises an upper limit tooth (11) and a lower limit tooth (16) respectively arranged on the upper joint socket (10) and the lower joint socket (15), and a plurality of first clamping grooves (9) and a second clamping groove (17) respectively arranged on the upper end plate joint structure and the lower end plate joint structure, the number and position of which correspond to the upper limit tooth (11) and the lower limit tooth (16); the upper limit teeth (11) are evenly spaced and distributed on the upper end surface of the upper joint socket (10). The lower limit teeth (16) are evenly spaced and distributed on the lower end surface of the lower joint socket (15); the upper limit teeth (11) are arranged on the top of the upper joint socket (10), and the lower limit teeth (16) are arranged on the bottom of the lower joint socket (15), and the free ends of the upper limit teeth (11) and the lower limit teeth (16) both point to the center of the joint socket; the first clamping grooves (9) are evenly spaced and arranged on the first joint ball (8), and the second clamping grooves (17) are evenly spaced and arranged on the second joint ball (21); The upper end plate (1), the lower end plate (3) and the bionic vertebral body (2) are all made by 3D printing.

2. The 3D printed bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex according to claim 1, characterized in that: The two first nail paths (6) are opened in front of the first platform (4). The support structure (5) is arranged behind the first platform (4). The structural area, and the highest point of the arc of the supporting structure (5) is located at the rear of the first platform (4). The height of the arc surface decreases smoothly towards the surrounding areas.

3. The 3D printed bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex according to claim 1, characterized in that: The lower end plate (3) comprises a second platform (18), the front section of which is provided with two pairs of second nail channels (19) with parallel axes and symmetrically distributed, and the axes of the two second nail channels (19) are arranged at an angle with the plane of the second platform (4) to facilitate the fixing of screws.

4. The 3D printed bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex according to claim 3, characterized in that: The two second nail paths (19) are opened in front of the second platform (18). Structural area.

5. The 3D printed bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex according to claim 1, characterized in that: A support column (13) is arranged inside the vertebral body (12). The support column (13) is a beveled cylinder, the upper surface of which is connected to the bottom end of the upper acetabulum (10) and extends smoothly to the periphery, and the lower surface is connected to the top end of the lower acetabulum (15) and extends smoothly to the periphery.

6. The 3D printed bionic anti-dislocation movable artificial cervical vertebra and intervertebral connection complex according to claim 1, characterized in that: The front side of the vertebral body (12) is provided with four layers of diamond-shaped through holes, with three holes arranged in a staggered manner in each layer; and the back side is provided with three layers, with three holes arranged in a staggered manner in each layer.

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