Citrate-sugar alcohol solution used for aerosol inhalation

Abstract

The invention provides an aqueous solution preparation of citrate and sugar alcohol for aerosol inhalation for reducing phlegm. The sugar alcohol is any one selected from the group consisting of mannitol, sorbitol, inositol, galactitol, xylitol, arabitol and erythritol, and has the advantages of greatly reducing the adverse reaction of dry throat and sore throat caused by the citrate and improvingthe administration concentration of the citrate at the same time.

Description

technical field

[0001] The invention belongs to the field of pharmacy, in particular, the invention relates to an aqueous solution for nebulized inhalation containing citrate and sugar alcohol. Background technique

[0002] Nebulization inhalation treatment is to disperse medicine and water into mist particles or particles suspended in the gas through the inhalation device, and deposit them in the respiratory tract and (or) lungs through inhalation, so as to achieve the effect of local treatment of the respiratory tract. Administration through nebulization inhalation can relieve bronchospasm, dilute sputum, and prevent respiratory tract infection. In many respiratory diseases, such as chronic obstructive pulmonary disease (COPD) in adults, bronchial asthma in children, acute laryngitis, allergic cough and other diseases, aerosol inhalation can be used for treatment. The biggest advantage of aerosol inhalation therapy is that the drug can directly reach the airway or lungs. ...

Examples

Embodiment 1-7

[0019]

[0020] According to the ingredient ratio shown in the above table, each material is diluted with water according to the corresponding ingredient ratio, and the pH value is adjusted to 7.0±0.5 with citric acid. If it is too high, then, respectively pack it into a solution preparation for atomization inhalation with each preparation unit being 2ml, fill it with nitrogen, seal it, and store it away from light.

Embodiment 8-14

[0022]

[0023] According to the ingredient ratio shown in the above table, each material is diluted with water according to the corresponding ingredient ratio, and the pH value is adjusted to 7.0±0.5 with citric acid. If it is too high, then, respectively pack it into a solution preparation for nebulization inhalation with each preparation unit being 3ml, fill it with nitrogen, seal it, and store it away from light.

Embodiment 15-21

[0025]

[0026] According to the ingredient ratio shown in the above table, each material is diluted with water according to the corresponding ingredient ratio, and the pH value is adjusted to 7.0±0.5 with citric acid. If it is too high, then, respectively pack it into a solution preparation for atomization inhalation with each preparation unit being 2ml, fill it with nitrogen, seal it, and store it away from light.

technical field

[0001] The invention belongs to the field of pharmacy, in particular, the invention relates to an aqueous solution for nebulized inhalation containing citrate and sugar alcohol. Background technique

[0002] Nebulization inhalation treatment is to disperse medicine and water into mist particles or particles suspended in the gas through the inhalation device, and deposit them in the respiratory tract and (or) lungs through inhalation, so as to achieve the effect of local treatment of the respiratory tract. Administration through nebulization inhalation can relieve bronchospasm, dilute sputum, and prevent respiratory tract infection. In many respiratory diseases, such as chronic obstructive pulmonary disease (COPD) in adults, bronchial asthma in children, acute laryngitis, allergic cough and other diseases, aerosol inhalation can be used for treatment. The biggest advantage of aerosol inhalation therapy is that the drug can directly reach the airway or lungs. ...

Examples

Embodiment 1-7

[0019]

[0020] According to the ingredient ratio shown in the above table, each material is diluted with water according to the corresponding ingredient ratio, and the pH value is adjusted to 7.0±0.5 with citric acid. If it is too high, then, respectively pack it into a solution preparation for atomization inhalation with each preparation unit being 2ml, fill it with nitrogen, seal it, and store it away from light.

Embodiment 8-14

[0022]

[0023] According to the ingredient ratio shown in the above table, each material is diluted with water according to the corresponding ingredient ratio, and the pH value is adjusted to 7.0±0.5 with citric acid. If it is too high, then, respectively pack it into a solution preparation for nebulization inhalation with each preparation unit being 3ml, fill it with nitrogen, seal it, and store it away from light.

Embodiment 15-21

[0025]

[0026] According to the ingredient ratio shown in the above table, each material is diluted with water according to the corresponding ingredient ratio, and the pH value is adjusted to 7.0±0.5 with citric acid. If it is too high, then, respectively pack it into a solution preparation for atomization inhalation with each preparation unit being 2ml, fill it with nitrogen, seal it, and store it away from light.

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