Indirect coupling simulation method of microfluidic dielectrophoresis sorting chip

A simulation method and dielectrophoresis technology, applied in the field of dielectrophoresis, can solve the problems of large sample size, low separation precision, inability to meet high precision of disease detection, low cost and high efficiency, etc.

CN111475983APending Publication Date: 2020-07-31GUANGDONG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2020-07-31

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Abstract

The invention discloses an indirect coupling simulation method of a microfluidic dielectrophoresis sorting chip, and relates to the technical field of dielectrophoresis. The method comprises the following steps: establishing a phase field model in a multiphase flow; adopting a finite element method to obtain dielectrophoretic force which changes along with time and space and is borne by particles;inputting the dielectrophoresis force as an external force item into the phase field model in the multiphase flow, and solving the phase field model in the multiphase flow to realize indirect coupling; adopting a lattice Boltzmann method to calculate the phase field model in the multiphase flow, calculating electric field intensity distribution in a chip and track and characterize motion trails of the particles. The advantages of the finite element grid method for solving the electric field can be exerted, the advantages of the lattice Boltzmann method for solving micro-scale flow and flexible cell deformation can also be exerted, the chip structure can be optimized according to the simulation result, and a new thought is provided for design and manufacturing of the microfluidic dielectrophoresis chip.
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Description

technical field

[0001] The invention relates to the technical field of dielectrophoresis, in particular to an indirect coupling simulation method of a microfluidic dielectrophoresis sorting chip. Background technique

[0002] Microfluidic chip technology integrates basic operating units such as sample preparation, pretreatment, reaction, separation, and detection in biological and chemical analysis processes into a micron-scale chip, which can realize the transportation and mixing of fluids, micro-nano particles, or droplets. , Sorting, enrichment, logic operations and other operations are of great strategic significance to the development of life sciences and information sciences. Under a non-uniform electric field, micro-nano-scale dielectric particles (such as polymer particles, various cells, bacteria, viruses, DNA, droplets, etc.) The strongest or weakest regions are clustered, respectively called dielectric positive.

[0003] The separation of biological particles (s...

Examples

Embodiment 1

[0058] Please refer to figure 1 , the present embodiment provides an indirect coupling simulation method for a microfluidic dielectrophoresis sorting chip, comprising the following steps;

[0059] Establishing a particle model, the particle model comprising a phase field model in a multiphase flow;

[0060] Using the finite element method (FEM) to obtain the dielectrophoretic force F of the particle that changes with time and space DEP ;

[0061] Dielectrophoretic force F DEP Input as an external force term into the phase field model in the multiphase flow, by inputting the electrophoretic force F of the external force term DEP Affect the macroscopic velocity u of the particle phase, and then affect the source term R of the phase field model in the multiphase flow, and then solve the phase field model in the multiphase flow to achieve indirect coupling;

[0062] The lattice Boltzmann method (LBM) is used to calculate the phase field model in the multiphase flow, the electr...